FZD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)5.95072714
2hemidesmosome assembly (GO:0031581)5.85087071
3COPI coating of Golgi vesicle (GO:0048205)4.62890148
4Golgi transport vesicle coating (GO:0048200)4.62890148
5desmosome organization (GO:0002934)4.43284259
6bundle of His cell to Purkinje myocyte communication (GO:0086069)4.33221669
7skin morphogenesis (GO:0043589)4.32341390
8regulation of cardioblast proliferation (GO:0003264)4.23934543
9regulation of secondary heart field cardioblast proliferation (GO:0003266)4.23934543
10keratinocyte proliferation (GO:0043616)4.07742181
11vascular endothelial growth factor signaling pathway (GO:0038084)3.97537890
12surfactant homeostasis (GO:0043129)3.97401637
13endothelium development (GO:0003158)3.91174502
14retina vasculature morphogenesis in camera-type eye (GO:0061299)3.83055847
15negative regulation of cell fate specification (GO:0009996)3.80755017
16thyroid hormone generation (GO:0006590)3.80702506
17cell adhesion mediated by integrin (GO:0033627)3.74247995
18atrioventricular valve morphogenesis (GO:0003181)3.70533464
19protein localization to endosome (GO:0036010)3.63879742
20regulation of transforming growth factor beta2 production (GO:0032909)3.62319556
21hypotonic response (GO:0006971)3.51492544
22regulation of water loss via skin (GO:0033561)3.51183103
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.46078054
24epithelial cell-cell adhesion (GO:0090136)3.44557434
25regulation of heart morphogenesis (GO:2000826)3.41599993
26mesodermal cell differentiation (GO:0048333)3.41405152
27protein hydroxylation (GO:0018126)3.41225300
28germ cell migration (GO:0008354)3.38929172
29cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.37070073
30polarized epithelial cell differentiation (GO:0030859)3.36360469
31lymphangiogenesis (GO:0001946)3.35979642
32positive regulation of hormone biosynthetic process (GO:0046886)3.34873268
33endothelial cell morphogenesis (GO:0001886)3.33149486
34establishment of skin barrier (GO:0061436)3.27741149
35regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.22624757
36peptidyl-proline hydroxylation (GO:0019511)3.18820368
37intestinal epithelial cell development (GO:0060576)3.16308232
38protein retention in ER lumen (GO:0006621)3.16146149
39neural crest cell development (GO:0014032)3.15997284
40cell-substrate junction assembly (GO:0007044)3.14641293
41heart valve morphogenesis (GO:0003179)3.13090504
42basement membrane organization (GO:0071711)3.12470784
43morphogenesis of an endothelium (GO:0003159)3.11976588
44endothelial tube morphogenesis (GO:0061154)3.11976588
45regulation of cardioblast differentiation (GO:0051890)3.11949080
46positive regulation of osteoblast proliferation (GO:0033690)3.10574266
47regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.08648547
48regulation of cell fate specification (GO:0042659)3.07923321
49muscle cell migration (GO:0014812)3.07186573
50definitive hemopoiesis (GO:0060216)3.07175042
51substrate-dependent cell migration (GO:0006929)3.04437696
52hippo signaling (GO:0035329)3.02712932
53embryonic heart tube development (GO:0035050)3.02262363
54gap junction assembly (GO:0016264)3.01946963
55establishment of apical/basal cell polarity (GO:0035089)3.00344345
56chemical homeostasis within a tissue (GO:0048875)2.99373337
57cell surface receptor signaling pathway involved in heart development (GO:0061311)2.99091139
58mammary gland epithelial cell proliferation (GO:0033598)2.96865019
59cell migration involved in sprouting angiogenesis (GO:0002042)2.95882270
60renal filtration (GO:0097205)2.93685285
61COPII vesicle coating (GO:0048208)2.93102959
62renal system development (GO:0072001)2.91601581
63regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.91069848
64regulation of hippo signaling (GO:0035330)2.90212745
65thyroid hormone metabolic process (GO:0042403)2.90179969
66vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.90058246
67Notch signaling involved in heart development (GO:0061314)2.89656190
68cellular response to vitamin (GO:0071295)2.87203017
69membrane raft organization (GO:0031579)2.86034965
70mesenchyme morphogenesis (GO:0072132)2.85834970
71membrane protein ectodomain proteolysis (GO:0006509)2.85238291
72sprouting angiogenesis (GO:0002040)2.83838088
73regulation of endothelial cell differentiation (GO:0045601)2.83811529
74* establishment of tissue polarity (GO:0007164)2.83040503
75* establishment of planar polarity (GO:0001736)2.83040503
76regulation of keratinocyte proliferation (GO:0010837)2.80131130
77mesenchymal cell development (GO:0014031)2.79518767
78planar cell polarity pathway involved in neural tube closure (GO:0090179)2.78362675
79exocrine pancreas development (GO:0031017)2.77496249
80positive regulation of endothelial cell apoptotic process (GO:2000353)2.76804081
81phospholipid scrambling (GO:0017121)2.76584062
82negative regulation of stem cell proliferation (GO:2000647)2.75543760
83keratinocyte differentiation (GO:0030216)2.75197266
84wound healing, spreading of cells (GO:0044319)2.74584602
85paraxial mesoderm development (GO:0048339)2.74148570
86nuclear pore complex assembly (GO:0051292)2.74001857
87regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.73964906
88cell junction assembly (GO:0034329)2.72670580
89heart valve formation (GO:0003188)2.72538224
90negative regulation of keratinocyte proliferation (GO:0010839)2.70063982
91endothelial cell differentiation (GO:0045446)2.69518081
92cell-substrate adherens junction assembly (GO:0007045)2.68184735
93focal adhesion assembly (GO:0048041)2.68184735
94negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.67110855
95adherens junction assembly (GO:0034333)2.66865052
96regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.66356412
97glomerular epithelial cell development (GO:0072310)2.66030236
98negative regulation of chondrocyte differentiation (GO:0032331)2.65917075
99cell-cell junction assembly (GO:0007043)2.64705066
100blood vessel maturation (GO:0001955)2.64667529
101regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.64377008
102endocardial cushion morphogenesis (GO:0003203)2.62996429
103fibroblast migration (GO:0010761)2.62650139
104dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.62441296
105endodermal cell differentiation (GO:0035987)2.62279514
106keratinocyte development (GO:0003334)2.61740571
107coronary vasculature morphogenesis (GO:0060977)2.61472431
108branching involved in salivary gland morphogenesis (GO:0060445)2.61212462
109collagen fibril organization (GO:0030199)2.60064200
110regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.59941076
111gland morphogenesis (GO:0022612)2.59712982
112morphogenesis of an epithelial sheet (GO:0002011)2.59086472
113wound healing, spreading of epidermal cells (GO:0035313)2.58615585
114vasculogenesis (GO:0001570)2.58295787
115epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.58118502
116venous blood vessel morphogenesis (GO:0048845)2.58067316
117regulation of steroid hormone biosynthetic process (GO:0090030)2.57923906
118antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.57333645
119antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.57333645
120positive regulation of hormone metabolic process (GO:0032352)2.56291680
121patterning of blood vessels (GO:0001569)2.56055888
122cytoskeletal anchoring at plasma membrane (GO:0007016)2.54846071
123regulation of transforming growth factor beta production (GO:0071634)2.54715116
124regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.54600213
125pericardium development (GO:0060039)2.54399674
126blood vessel endothelial cell migration (GO:0043534)2.53212947
127positive regulation of epidermal cell differentiation (GO:0045606)2.52696762
128regulation of vasculogenesis (GO:2001212)2.52432368
129regulation of transforming growth factor beta1 production (GO:0032908)2.52431391
130retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.51757221
131regulation of keratinocyte differentiation (GO:0045616)2.50916243
132embryonic foregut morphogenesis (GO:0048617)2.50544498
133peptidyl-tyrosine autophosphorylation (GO:0038083)2.50290790
134regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.50004295
135glomerular visceral epithelial cell development (GO:0072015)2.49915221
136regulation of somitogenesis (GO:0014807)2.49648472
137aorta morphogenesis (GO:0035909)2.49619518
138cell junction organization (GO:0034330)2.48497248
139negative regulation of cartilage development (GO:0061037)2.48442938
140smooth muscle tissue development (GO:0048745)2.48056590
141chondrocyte proliferation (GO:0035988)2.47611251
142vesicle coating (GO:0006901)2.46217799
143multicellular organismal water homeostasis (GO:0050891)2.45167682
144branching involved in mammary gland duct morphogenesis (GO:0060444)2.45167528
145antigen processing and presentation of endogenous antigen (GO:0019883)2.45154326
146negative regulation of cell fate commitment (GO:0010454)2.44751247
147blood vessel morphogenesis (GO:0048514)2.43546356
148atrial septum morphogenesis (GO:0060413)2.43437306
149hepatocyte differentiation (GO:0070365)2.42092910
150tight junction assembly (GO:0070830)2.41196880
151heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.40942540
152negative regulation of anoikis (GO:2000811)2.40483006
153stem cell development (GO:0048864)2.40440594
154neuron projection extension involved in neuron projection guidance (GO:1902284)2.40066714
155axon extension involved in axon guidance (GO:0048846)2.40066714
156cardiac epithelial to mesenchymal transition (GO:0060317)2.39340858
157activation of Rac GTPase activity (GO:0032863)2.38836033
158cellular response to vitamin D (GO:0071305)2.38818897
159cardiac right ventricle morphogenesis (GO:0003215)2.38260620
160mRNA transcription (GO:0009299)2.37699388
161mesenchymal-epithelial cell signaling (GO:0060638)2.37338641
162regulation of metalloenzyme activity (GO:0048552)2.36371523
163positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.36193276
164regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.35966370
165positive regulation of epithelial to mesenchymal transition (GO:0010718)2.35906852
166positive regulation of vasculogenesis (GO:2001214)2.35782700
167regulation of osteoblast proliferation (GO:0033688)2.35780619
168mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.35671646
169extracellular matrix disassembly (GO:0022617)2.35039105
170nuclear pore organization (GO:0006999)2.34810115
171regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.33315869
172wound healing (GO:0042060)2.32854368
173protein localization to cell surface (GO:0034394)2.32825960
174ER overload response (GO:0006983)2.32816267

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.55470432
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.81916074
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.02235592
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.13015805
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.02298746
6AR_21909140_ChIP-Seq_LNCAP_Human3.00272497
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.87570074
8GATA2_21666600_ChIP-Seq_HMVEC_Human2.60356455
9CLOCK_20551151_ChIP-Seq_293T_Human2.38616125
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30462758
11SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.27004776
12SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.27004776
13ZNF217_24962896_ChIP-Seq_MCF-7_Human2.26720181
14* EP300_21415370_ChIP-Seq_HL-1_Mouse2.21935685
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20306278
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.16283573
17* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.13505305
18CJUN_26792858_Chip-Seq_BT549_Human2.03708765
19* SOX2_20726797_ChIP-Seq_SW620_Human2.03447653
20E2F7_22180533_ChIP-Seq_HELA_Human1.96360668
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.96299069
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.93958682
23FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.93593594
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.84335602
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.83391660
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82292510
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.79995162
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74520059
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.69982449
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.67892450
31TCF4_18268006_ChIP-ChIP_LS174T_Human1.65562832
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.65495264
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63900815
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63404725
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62860905
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.62362188
37CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.59144077
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55573810
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50449483
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49898306
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49258617
42P63_26484246_Chip-Seq_KERATINOCYTES_Human1.46308810
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45992088
44TP53_18474530_ChIP-ChIP_U2OS_Human1.44442792
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.43856932
46* BRD4_25478319_ChIP-Seq_HGPS_Human1.41320970
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40258245
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39933166
49AHR_22903824_ChIP-Seq_MCF-7_Human1.39709944
50TBX20_22328084_ChIP-Seq_HEART_Mouse1.39049507
51TBX20_22080862_ChIP-Seq_HEART_Mouse1.39049507
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37744164
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37242572
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.36129486
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35698134
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35599525
57GATA4_25053715_ChIP-Seq_YYC3_Human1.33376229
58ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.31793014
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.29067322
60CDX2_20551321_ChIP-Seq_CACO-2_Human1.28868490
61* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26517977
62* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26517977
63TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23920055
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23072550
65JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22004763
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21451890
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20509709
68* TP63_23658742_ChIP-Seq_EP156T_Human1.20418481
69RUNX1_27514584_Chip-Seq_MCF-7_Human1.19418032
70ISL1_27105846_Chip-Seq_CPCs_Mouse1.19394168
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.19339867
72TP53_16413492_ChIP-PET_HCT116_Human1.19261687
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17145159
74* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16057762
75* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15624343
76* UBF1/2_26484160_Chip-Seq_HMECs_Human1.15450041
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13815495
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12756718
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.12332177
80SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12249189
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11342603
82GATA3_24758297_ChIP-Seq_MCF-7_Human1.10299613
83CHD1_26751641_Chip-Seq_LNCaP_Human1.10233272
84NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09401302
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07534327
86FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07329439
87* KLF5_25053715_ChIP-Seq_YYC3_Human1.07028663
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06898794
89GATA6_25053715_ChIP-Seq_YYC3_Human1.06032528
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05327038
91JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05292013
92SOX17_20123909_ChIP-Seq_XEN_Mouse1.05284892
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02731972
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02516904
95ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02494437
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00694645
97TP53_22127205_ChIP-Seq_IMR90_Human1.00172826
98SCL_19346495_ChIP-Seq_HPC-7_Human1.00169096
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99815021
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99255848
101NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98347816
102GATA1_22025678_ChIP-Seq_K562_Human0.98025310
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96412277
104IRF8_22096565_ChIP-ChIP_GC-B_Human0.96216143
105RXR_22108803_ChIP-Seq_LS180_Human0.95460637
106SMAD3_21741376_ChIP-Seq_HESCs_Human0.95243707
107CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94670519
108ZNF263_19887448_ChIP-Seq_K562_Human0.94000659
109NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92794049
110ELK3_25401928_ChIP-Seq_HUVEC_Human0.92576925
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91569862
112RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91327529
113* TP53_20018659_ChIP-ChIP_R1E_Mouse0.90665276
114ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90127390
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89753749
116VDR_24787735_ChIP-Seq_THP-1_Human0.89165343
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89132707
118SALL1_21062744_ChIP-ChIP_HESCs_Human0.89010317
119RACK7_27058665_Chip-Seq_MCF-7_Human0.88834625
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88806697
121AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88775277
122MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.88581893
123EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88031378
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87811235
125EED_16625203_ChIP-ChIP_MESCs_Mouse0.84490716
126MYC_18555785_ChIP-Seq_MESCs_Mouse0.84471278
127* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.83693358
128BCAT_22108803_ChIP-Seq_LS180_Human0.83636923
129FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80411528
130WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79310858
131ATF3_27146783_Chip-Seq_COLON_Human0.76242688

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.84367405
2MP0010234_abnormal_vibrissa_follicle3.19916861
3MP0004272_abnormal_basement_membrane3.19565730
4MP0010368_abnormal_lymphatic_system3.04606494
5MP0005275_abnormal_skin_tensile3.00660242
6MP0001879_abnormal_lymphatic_vessel2.99181192
7MP0003941_abnormal_skin_development2.60829184
8MP0005257_abnormal_intraocular_pressure2.51687018
9MP0002877_abnormal_melanocyte_morpholog2.42080508
10MP0005623_abnormal_meninges_morphology2.39662740
11MP0006054_spinal_hemorrhage2.32600969
12MP0009780_abnormal_chondrocyte_physiolo2.30109850
13MP0003950_abnormal_plasma_membrane2.26651271
14* MP0010678_abnormal_skin_adnexa2.22727152
15* MP0000383_abnormal_hair_follicle2.18975183
16MP0002098_abnormal_vibrissa_morphology2.13857003
17MP0003566_abnormal_cell_adhesion2.13456078
18MP0001346_abnormal_lacrimal_gland2.11906503
19MP0003705_abnormal_hypodermis_morpholog2.07524655
20MP0008438_abnormal_cutaneous_collagen2.07213649
21MP0005167_abnormal_blood-brain_barrier1.92736903
22MP0002796_impaired_skin_barrier1.82655565
23MP0002060_abnormal_skin_morphology1.82076514
24MP0000579_abnormal_nail_morphology1.78649054
25MP0000537_abnormal_urethra_morphology1.65895371
26MP0003828_pulmonary_edema1.63305776
27MP0009384_cardiac_valve_regurgitation1.61157306
28MP0005367_renal/urinary_system_phenotyp1.58894584
29MP0000516_abnormal_urinary_system1.58894584
30MP0003279_aneurysm1.56621561
31MP0005377_hearing/vestibular/ear_phenot1.55832036
32MP0003878_abnormal_ear_physiology1.55832036
33MP0010352_gastrointestinal_tract_polyps1.49835861
34MP0000762_abnormal_tongue_morphology1.49192211
35MP0005503_abnormal_tendon_morphology1.48098693
36MP0002234_abnormal_pharynx_morphology1.46767581
37MP0000767_abnormal_smooth_muscle1.46558961
38MP0004084_abnormal_cardiac_muscle1.44695420
39MP0010030_abnormal_orbit_morphology1.43231160
40MP0003453_abnormal_keratinocyte_physiol1.37086237
41MP0003300_gastrointestinal_ulcer1.36577637
42MP0006138_congestive_heart_failure1.36451999
43MP0005508_abnormal_skeleton_morphology1.36192994
44MP0000566_synostosis1.36169015
45MP0005409_darkened_coat_color1.34236637
46MP0000013_abnormal_adipose_tissue1.31297461
47MP0005501_abnormal_skin_physiology1.25835621
48MP0000377_abnormal_hair_follicle1.24861157
49MP0001958_emphysema1.23717960
50MP0000733_abnormal_muscle_development1.22511505
51MP0009278_abnormal_bone_marrow1.21734507
52MP0001849_ear_inflammation1.21354048
53MP0009379_abnormal_foot_pigmentation1.21329328
54MP0005171_absent_coat_pigmentation1.20082885
55MP0005248_abnormal_Harderian_gland1.17186869
56MP0001216_abnormal_epidermal_layer1.15731477
57MP0000462_abnormal_digestive_system1.15345936
58MP0002009_preneoplasia1.14272357
59MP0003191_abnormal_cellular_cholesterol1.13500184
60MP0005197_abnormal_uvea_morphology1.12884199
61MP0001299_abnormal_eye_distance/1.12481523
62MP0000627_abnormal_mammary_gland1.12422251
63MP0002896_abnormal_bone_mineralization1.09932113
64MP0005076_abnormal_cell_differentiation1.09551817
65MP0010630_abnormal_cardiac_muscle1.08686227
66MP0001243_abnormal_dermal_layer1.08363030
67MP0004233_abnormal_muscle_weight1.08240530
68MP0003935_abnormal_craniofacial_develop1.06772053
69MP0009250_abnormal_appendicular_skeleto1.06456435
70MP0005023_abnormal_wound_healing1.06417117
71MP0002925_abnormal_cardiovascular_devel1.02745304
72MP0000647_abnormal_sebaceous_gland1.01611873
73MP0009053_abnormal_anal_canal1.01374200
74MP0003385_abnormal_body_wall0.99034036
75MP0000003_abnormal_adipose_tissue0.98203406
76MP0000613_abnormal_salivary_gland0.98102740
77MP0000534_abnormal_ureter_morphology0.97888129
78MP0004808_abnormal_hematopoietic_stem0.96843136
79MP0002697_abnormal_eye_size0.96731791
80MP0003045_fibrosis0.96361823
81MP0009697_abnormal_copulation0.96125181
82MP0003091_abnormal_cell_migration0.96094848
83MP0000467_abnormal_esophagus_morphology0.95061827
84MP0004957_abnormal_blastocyst_morpholog0.94974947
85MP0001542_abnormal_bone_strength0.94495388
86MP0004185_abnormal_adipocyte_glucose0.93582223
87MP0005408_hypopigmentation0.93139201
88MP0004484_altered_response_of0.92245064
89MP0002166_altered_tumor_susceptibility0.91841807
90MP0002972_abnormal_cardiac_muscle0.91580480
91MP0000681_abnormal_thyroid_gland0.91514264
92MP0000428_abnormal_craniofacial_morphol0.91019260
93MP0002282_abnormal_trachea_morphology0.90756253
94MP0002138_abnormal_hepatobiliary_system0.90570686
95MP0002128_abnormal_blood_circulation0.89800656
96MP0000163_abnormal_cartilage_morphology0.88957572
97* MP0010771_integument_phenotype0.86501445
98MP0005084_abnormal_gallbladder_morpholo0.86243116
99MP0002249_abnormal_larynx_morphology0.85758403
100MP0004782_abnormal_surfactant_physiolog0.85485236
101MP0002233_abnormal_nose_morphology0.84835607
102MP0000432_abnormal_head_morphology0.84606637
103MP0002084_abnormal_developmental_patter0.84519181
104MP0000678_abnormal_parathyroid_gland0.84254226
105MP0001270_distended_abdomen0.83915701
106MP0002086_abnormal_extraembryonic_tissu0.83527988
107MP0002938_white_spotting0.83095018
108MP0003943_abnormal_hepatobiliary_system0.81835278
109MP0001614_abnormal_blood_vessel0.81694075
110MP0003315_abnormal_perineum_morphology0.81029692
111MP0002092_abnormal_eye_morphology0.80876700
112MP0000049_abnormal_middle_ear0.80220799
113MP0005193_abnormal_anterior_eye0.79860945
114MP0000465_gastrointestinal_hemorrhage0.79784555
115MP0004264_abnormal_extraembryonic_tissu0.78807993
116MP0001915_intracranial_hemorrhage0.78180861
117MP0003942_abnormal_urinary_system0.78094342
118MP0003724_increased_susceptibility_to0.77804184
119MP0005385_cardiovascular_system_phenoty0.77756422
120MP0001544_abnormal_cardiovascular_syste0.77756422
121MP0009931_abnormal_skin_appearance0.77603827
122MP0005621_abnormal_cell_physiology0.76978293
123MP0000427_abnormal_hair_cycle0.76874253
124MP0001661_extended_life_span0.76862221
125MP0002177_abnormal_outer_ear0.75918161
126MP0005330_cardiomyopathy0.75777929
127MP0001784_abnormal_fluid_regulation0.75498312
128MP0000858_altered_metastatic_potential0.75051032
129MP0001191_abnormal_skin_condition0.74612065
130MP0005165_increased_susceptibility_to0.74463079
131MP0003937_abnormal_limbs/digits/tail_de0.74300401
132MP0003984_embryonic_growth_retardation0.74155884
133MP0003755_abnormal_palate_morphology0.74052541
134MP0008932_abnormal_embryonic_tissue0.73740829
135MP0001348_abnormal_lacrimal_gland0.73346518
136MP0002295_abnormal_pulmonary_circulatio0.72899740
137MP0001340_abnormal_eyelid_morphology0.71954815
138MP0002088_abnormal_embryonic_growth/wei0.70498073
139MP0005164_abnormal_response_to0.69979145
140MP0001672_abnormal_embryogenesis/_devel0.69273531

Predicted human phenotypes

RankGene SetZ-score
1* Onycholysis (HP:0001806)4.73671199
2Right ventricular cardiomyopathy (HP:0011663)4.49589713
3Atrophic scars (HP:0001075)4.49046123
4Pili torti (HP:0003777)4.27624642
5Milia (HP:0001056)4.24854892
6Fragile nails (HP:0001808)3.18383911
7Woolly hair (HP:0002224)3.05928941
8Aplasia cutis congenita (HP:0001057)3.03038722
9Congenital, generalized hypertrichosis (HP:0004540)3.01413490
10Selective tooth agenesis (HP:0001592)2.96747933
11Rectal prolapse (HP:0002035)2.87383768
12Plantar hyperkeratosis (HP:0007556)2.86321735
13Premature rupture of membranes (HP:0001788)2.85906399
14Hematochezia (HP:0002573)2.75054365
15Arterial tortuosity (HP:0005116)2.73609707
16Absent frontal sinuses (HP:0002688)2.68186498
17Ventricular tachycardia (HP:0004756)2.66521959
18Vascular tortuosity (HP:0004948)2.65562716
19Ankyloglossia (HP:0010296)2.59377825
20Subacute progressive viral hepatitis (HP:0006572)2.55090467
21Natal tooth (HP:0000695)2.54499462
22Hypotrichosis (HP:0001006)2.54312401
23Fragile skin (HP:0001030)2.52353054
24Amelogenesis imperfecta (HP:0000705)2.52151613
25Broad metatarsal (HP:0001783)2.50663524
26Asymmetry of the thorax (HP:0001555)2.48534413
27Aortic dissection (HP:0002647)2.47750157
28Distal lower limb muscle weakness (HP:0009053)2.44476425
29Lip pit (HP:0100267)2.42516950
30Hypoplasia of the iris (HP:0007676)2.42494653
31Cardiovascular calcification (HP:0011915)2.42260685
32Vertebral compression fractures (HP:0002953)2.38640522
33Alopecia of scalp (HP:0002293)2.35868788
34Cervical subluxation (HP:0003308)2.35411090
35Follicular hyperkeratosis (HP:0007502)2.34957352
36Abnormality of oral frenula (HP:0000190)2.34733316
37Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.34713719
38Advanced eruption of teeth (HP:0006288)2.33207761
39Protrusio acetabuli (HP:0003179)2.33014577
40Nail dystrophy (HP:0008404)2.32914389
41Vertebral arch anomaly (HP:0008438)2.31108377
42Bladder diverticulum (HP:0000015)2.28580782
43Abnormality of dentin (HP:0010299)2.27701871
44Ulnar bowing (HP:0003031)2.26910717
45Mitral stenosis (HP:0001718)2.26437291
46Increased connective tissue (HP:0009025)2.25948120
47Cerebral aneurysm (HP:0004944)2.25449100
48Neonatal short-limb short stature (HP:0008921)2.22398524
49Flat acetabular roof (HP:0003180)2.20143958
50Microglossia (HP:0000171)2.19541235
51Abnormal hair laboratory examination (HP:0003328)2.17476095
52Vascular calcification (HP:0004934)2.17278115
53Spinal cord lesions (HP:0100561)2.16557243
54Syringomyelia (HP:0003396)2.16557243
55Aortic aneurysm (HP:0004942)2.15709538
56Short nail (HP:0001799)2.15698989
57Epiphyseal dysplasia (HP:0002656)2.13099072
58Shallow orbits (HP:0000586)2.12378081
59Esophageal varix (HP:0002040)2.11175358
60Hypoplastic ischia (HP:0003175)2.09884463
61Osteolytic defects of the hand bones (HP:0009699)2.09279543
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.09279543
63Muscle fiber splitting (HP:0003555)2.07679968
64Short hallux (HP:0010109)2.05240590
65Elbow flexion contracture (HP:0002987)1.98957173
66Hypoplasia of dental enamel (HP:0006297)1.98384419
67Broad face (HP:0000283)1.94168306
68Unilateral renal agenesis (HP:0000122)1.93957616
69Sparse eyelashes (HP:0000653)1.93480521
70Abnormality of the gastric mucosa (HP:0004295)1.93393857
71Portal hypertension (HP:0001409)1.91022137
72Spinal rigidity (HP:0003306)1.90118758
73Limb-girdle muscle atrophy (HP:0003797)1.90073115
74Deviation of the thumb (HP:0009603)1.89466581
75Abnormality of carpal bone ossification (HP:0006257)1.89320431
76Abnormality of the acetabulum (HP:0003170)1.88870845
77Bronchomalacia (HP:0002780)1.88834348
78Micronodular cirrhosis (HP:0001413)1.87692028
79Pterygium (HP:0001059)1.86524231
80Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.86078045
81Abnormality of the frontal sinuses (HP:0002687)1.82561807
82Palmoplantar hyperkeratosis (HP:0000972)1.82265579
83Tetraparesis (HP:0002273)1.81426179
84Abnormality of the umbilical cord (HP:0010881)1.81288065
85Absent eyelashes (HP:0000561)1.80999237
86Spinal cord compression (HP:0002176)1.80652438
87Aplasia/Hypoplasia of the hallux (HP:0008362)1.79512517
88Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.78948765
89Vertebral hypoplasia (HP:0008417)1.78948765
90Hydroureter (HP:0000072)1.78403010
91Glucose intolerance (HP:0000833)1.77996677
92Trismus (HP:0000211)1.77286777
93Knee flexion contracture (HP:0006380)1.77252692
94Spondylolisthesis (HP:0003302)1.76670877
95Abnormality of the distal phalanges of the toes (HP:0010182)1.76054565
96Abnormality of the ischium (HP:0003174)1.75852366
97Abnormal blistering of the skin (HP:0008066)1.75463437
98Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.75174446
99Abnormal umbilical cord blood vessels (HP:0011403)1.75097038
100Single umbilical artery (HP:0001195)1.75097038
101Abnormality of the fetal cardiovascular system (HP:0010948)1.75097038
102Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74612676
103Mesomelia (HP:0003027)1.73841751
104Palmar hyperkeratosis (HP:0010765)1.73269708
105Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.72356157
106Abnormal ossification of hand bones (HP:0005921)1.70451842
107Scapular winging (HP:0003691)1.70207502
108Aneurysm (HP:0002617)1.70124820
109Stenosis of the external auditory canal (HP:0000402)1.69299557
110Spontaneous hematomas (HP:0007420)1.68801718
111Reduced subcutaneous adipose tissue (HP:0003758)1.68711224
112Radial bowing (HP:0002986)1.68118211
113Blue sclerae (HP:0000592)1.68089561
114Abnormality of nail color (HP:0100643)1.67992401
115Abnormality of the hepatic vasculature (HP:0006707)1.67784902
116Popliteal pterygium (HP:0009756)1.67739889
117Abnormality of the dental root (HP:0006486)1.67502779
118Taurodontia (HP:0000679)1.67502779
119Abnormality of permanent molar morphology (HP:0011071)1.67502779
120Back pain (HP:0003418)1.67404581
121Abnormality of molar (HP:0011077)1.67362528
122Abnormality of molar morphology (HP:0011070)1.67362528
123Hyporeflexia of lower limbs (HP:0002600)1.66561395
124Ridged nail (HP:0001807)1.66239325
125Abnormalities of placenta or umbilical cord (HP:0001194)1.65766942
126Soft skin (HP:0000977)1.64690701
127Ankle contracture (HP:0006466)1.63707178
128Lymphangioma (HP:0100764)1.61353262
129Craniofacial hyperostosis (HP:0004493)1.61192675
130Atrial fibrillation (HP:0005110)1.60477040
131Abnormality of the right ventricle (HP:0001707)1.59923052
132Abnormality of the 2nd finger (HP:0004100)1.59864947
133Mitral valve prolapse (HP:0001634)1.59558624
134Ureteral obstruction (HP:0006000)1.58351822
135Thick nail (HP:0001805)1.58320959
136Aplasia involving bones of the upper limbs (HP:0009823)1.56708574
137Aplasia of the phalanges of the hand (HP:0009802)1.56708574
138Aplasia involving bones of the extremities (HP:0009825)1.56708574
139Germ cell neoplasia (HP:0100728)1.56161594
140Adactyly (HP:0009776)1.55636231
141Increased IgE level (HP:0003212)1.55193847
142Absent toe (HP:0010760)1.54869003
143Neonatal death (HP:0003811)1.54473997
144Bell-shaped thorax (HP:0001591)1.53272610
145Distal lower limb amyotrophy (HP:0008944)1.52564419
146Pulmonary artery stenosis (HP:0004415)1.51941462
147Tarsal synostosis (HP:0008368)1.51918990
148Blepharitis (HP:0000498)1.51471068
149Abnormality of the nasal septum (HP:0000419)1.51345033
150Polycythemia (HP:0001901)1.51126799
151Down-sloping shoulders (HP:0200021)1.51003329
152Wormian bones (HP:0002645)1.50001574

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.11328504
2EPHA23.08858509
3KDR3.02715569
4LATS12.89310422
5SCYL22.67967070
6TTN2.65476356
7TGFBR22.53703964
8EPHB22.49649572
9TGFBR12.40460462
10FRK2.38518993
11PBK2.33532132
12DDR22.21733651
13FER2.15694801
14MST42.15625273
15PTK62.11403433
16RIPK12.08701754
17LATS21.97556251
18MAP3K121.82362351
19TRPM71.81996532
20PDGFRA1.80025433
21NTRK11.77614616
22TESK11.70534726
23MYLK1.68575760
24LMTK21.64657726
25LRRK21.52900869
26MAP3K31.52312494
27ERBB41.51741424
28ERBB31.44518699
29PTK21.38776426
30MET1.38271192
31SIK11.38001713
32FGFR21.36242296
33NUAK11.35970618
34EIF2AK11.32319590
35PAK41.30688518
36BRSK21.28427456
37MAP3K141.26507236
38MAPK151.25951180
39DMPK1.25101201
40MAP3K61.22148696
41MAPKAPK31.19846766
42FGFR31.17987107
43NME21.16802618
44GRK11.15539648
45LIMK11.15091858
46EPHA31.12415436
47PTK2B1.11259702
48PRKG21.10873673
49MST1R1.10300251
50NEK11.10203718
51INSRR1.08109225
52STK31.07791598
53EIF2AK31.07638312
54PKN21.06109483
55RPS6KB21.00359615
56NLK1.00049188
57ICK0.99433236
58STK380.98298933
59AKT30.97200641
60EPHB10.96382416
61TRIB30.95006825
62PAK20.94792420
63PIM20.92478181
64RPS6KA40.92394141
65CDK60.90713480
66BCR0.88412729
67SMG10.87630558
68ARAF0.87253881
69CDK120.86148609
70ZAK0.85859725
71BMX0.84041006
72JAK30.82808253
73TTK0.82591458
74NEK90.82219071
75CHUK0.82060505
76DYRK1B0.82034627
77PIK3CA0.81480682
78STK100.81115306
79STK38L0.78797323
80FGFR40.78177071
81MAP2K30.74745732
82CDK80.74045749
83SIK30.73966182
84MOS0.72947689
85BMPR1B0.71899217
86TEC0.69266129
87ROCK10.69253679
88TRIM280.68403363
89EEF2K0.67636572
90TSSK60.65513467
91ERBB20.63470302
92PAK30.62999651
93ROCK20.62506610
94SRPK10.61562705
95PDGFRB0.61005259
96MATK0.60647334
97FGFR10.60197453
98BRSK10.59196437
99BRD40.58429555
100CDK90.56511611
101BUB10.54689789
102MAP2K20.53853113
103HIPK20.53679424
104PDK20.52706832
105FLT30.52693828
106IGF1R0.51873335
107MELK0.50873190
108PRKD10.50589339
109ILK0.50315480
110STK390.50105952
111ITK0.49253950
112IRAK30.49215011
113PRKCE0.48586755
114ABL20.48011730
115NEK60.47644457
116ERN10.46435447
117STK240.46043540
118WEE10.44784113
119AURKB0.43625805
120PIK3CG0.43539885
121MAPKAPK20.42591268
122MAP3K20.41252881
123OBSCN0.41148834
124BTK0.41110849
125PASK0.40973679
126CDK70.39787614
127AKT20.39286221
128PRKAA20.38816769
129GSK3A0.37900310
130PRKCI0.37825910
131EGFR0.36996625
132RPS6KA20.36908363
133MARK30.35589427
134MKNK10.35507212
135RET0.35358060
136MAP2K10.35131365
137SRC0.34896079
138MTOR0.32768439
139MAP3K90.32604857
140KSR10.31646326
141EIF2AK20.31516378
142PLK10.31207217
143RPS6KA60.29463764
144INSR0.28788866
145MAP3K80.26229229

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.59229782
2Adherens junction_Homo sapiens_hsa045203.26002232
3Focal adhesion_Homo sapiens_hsa045102.73483887
4Small cell lung cancer_Homo sapiens_hsa052222.48823603
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.40237796
6Leukocyte transendothelial migration_Homo sapiens_hsa046702.25134865
7* Hippo signaling pathway_Homo sapiens_hsa043902.00812945
8* Proteoglycans in cancer_Homo sapiens_hsa052051.96767428
9TGF-beta signaling pathway_Homo sapiens_hsa043501.94005536
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.92127796
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.90016829
12Tight junction_Homo sapiens_hsa045301.87431575
13Amoebiasis_Homo sapiens_hsa051461.84603140
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.83525941
15Protein digestion and absorption_Homo sapiens_hsa049741.79232617
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.78777687
17Dilated cardiomyopathy_Homo sapiens_hsa054141.71577567
18* Basal cell carcinoma_Homo sapiens_hsa052171.61202590
19Toxoplasmosis_Homo sapiens_hsa051451.57574441
20N-Glycan biosynthesis_Homo sapiens_hsa005101.56407117
21Notch signaling pathway_Homo sapiens_hsa043301.54103288
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49678853
23PI3K-Akt signaling pathway_Homo sapiens_hsa041511.44336498
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.44326302
25Bladder cancer_Homo sapiens_hsa052191.42769747
26Sphingolipid metabolism_Homo sapiens_hsa006001.41672540
27MicroRNAs in cancer_Homo sapiens_hsa052061.40684797
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.37208578
29* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.36623636
30* Pathways in cancer_Homo sapiens_hsa052001.30243018
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21814952
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19517707
33Renal cell carcinoma_Homo sapiens_hsa052111.18305707
34Melanoma_Homo sapiens_hsa052181.17972796
35Rap1 signaling pathway_Homo sapiens_hsa040151.16640130
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15913125
37Chronic myeloid leukemia_Homo sapiens_hsa052201.15758005
38Autoimmune thyroid disease_Homo sapiens_hsa053201.14120136
39Viral myocarditis_Homo sapiens_hsa054161.13546906
40Prostate cancer_Homo sapiens_hsa052151.12994415
41TNF signaling pathway_Homo sapiens_hsa046681.10924937
42Thyroid cancer_Homo sapiens_hsa052161.10502104
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07887406
44Leishmaniasis_Homo sapiens_hsa051401.07629772
45Hedgehog signaling pathway_Homo sapiens_hsa043401.04887966
46Phenylalanine metabolism_Homo sapiens_hsa003601.02124611
47Thyroid hormone synthesis_Homo sapiens_hsa049181.00612382
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00519941
49Platelet activation_Homo sapiens_hsa046111.00291256
50Cell cycle_Homo sapiens_hsa041100.99587514
51Malaria_Homo sapiens_hsa051440.98788801
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.98024810
53Mineral absorption_Homo sapiens_hsa049780.94321493
54* HTLV-I infection_Homo sapiens_hsa051660.91657597
55* Wnt signaling pathway_Homo sapiens_hsa043100.91497904
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91327304
57Pancreatic cancer_Homo sapiens_hsa052120.87644967
58Endometrial cancer_Homo sapiens_hsa052130.87550903
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87227869
60Vibrio cholerae infection_Homo sapiens_hsa051100.87175442
61p53 signaling pathway_Homo sapiens_hsa041150.87171530
62ErbB signaling pathway_Homo sapiens_hsa040120.85522797
63Glioma_Homo sapiens_hsa052140.83847355
64Insulin resistance_Homo sapiens_hsa049310.83737274
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83430792
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81032921
67* Melanogenesis_Homo sapiens_hsa049160.80626844
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79934925
69Salmonella infection_Homo sapiens_hsa051320.79820178
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79608150
71Sulfur metabolism_Homo sapiens_hsa009200.78256109
72Nucleotide excision repair_Homo sapiens_hsa034200.78173930
73Ovarian steroidogenesis_Homo sapiens_hsa049130.77875847
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77834633
75FoxO signaling pathway_Homo sapiens_hsa040680.77577896
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75794413
77Pentose phosphate pathway_Homo sapiens_hsa000300.75625231
78Non-homologous end-joining_Homo sapiens_hsa034500.74222812
79Galactose metabolism_Homo sapiens_hsa000520.71335918
80Glutathione metabolism_Homo sapiens_hsa004800.71248978
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.70822373
82HIF-1 signaling pathway_Homo sapiens_hsa040660.68994504
83Antigen processing and presentation_Homo sapiens_hsa046120.68635015
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68234206
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68008319
86Legionellosis_Homo sapiens_hsa051340.67074782
87Dorso-ventral axis formation_Homo sapiens_hsa043200.66806963
88Vitamin B6 metabolism_Homo sapiens_hsa007500.66746159
89Axon guidance_Homo sapiens_hsa043600.66527307
90Inositol phosphate metabolism_Homo sapiens_hsa005620.65973118
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.65371078
92Arachidonic acid metabolism_Homo sapiens_hsa005900.65171458
93Shigellosis_Homo sapiens_hsa051310.65105550
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64491051
95Endocytosis_Homo sapiens_hsa041440.63805772
96Hepatitis C_Homo sapiens_hsa051600.63357732
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63279773
98Non-small cell lung cancer_Homo sapiens_hsa052230.63008405
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62572825
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62394409
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61859148
102Hematopoietic cell lineage_Homo sapiens_hsa046400.61778047
103Biosynthesis of amino acids_Homo sapiens_hsa012300.61468930
104Fatty acid elongation_Homo sapiens_hsa000620.61079862
105Ras signaling pathway_Homo sapiens_hsa040140.60515194
106Apoptosis_Homo sapiens_hsa042100.60357800
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60260429
108Colorectal cancer_Homo sapiens_hsa052100.59532249
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59463467
110RNA transport_Homo sapiens_hsa030130.59318958
111Measles_Homo sapiens_hsa051620.58578928
112Pertussis_Homo sapiens_hsa051330.57681270
113Protein export_Homo sapiens_hsa030600.56826260
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56205913
115Hepatitis B_Homo sapiens_hsa051610.56082345
116Circadian rhythm_Homo sapiens_hsa047100.56073343
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54610154
118Other glycan degradation_Homo sapiens_hsa005110.53073100
119Influenza A_Homo sapiens_hsa051640.52405847
120Lysine degradation_Homo sapiens_hsa003100.52308216
121Insulin signaling pathway_Homo sapiens_hsa049100.52086231
122mTOR signaling pathway_Homo sapiens_hsa041500.50919773
123AMPK signaling pathway_Homo sapiens_hsa041520.49222330
124Chemical carcinogenesis_Homo sapiens_hsa052040.48939978
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46705852
126ABC transporters_Homo sapiens_hsa020100.46483426
127Prolactin signaling pathway_Homo sapiens_hsa049170.46146714
128Caffeine metabolism_Homo sapiens_hsa002320.45929089
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.45803285
130VEGF signaling pathway_Homo sapiens_hsa043700.45622193
131Herpes simplex infection_Homo sapiens_hsa051680.45253294
132Steroid biosynthesis_Homo sapiens_hsa001000.44758830
133Gap junction_Homo sapiens_hsa045400.44470866
134African trypanosomiasis_Homo sapiens_hsa051430.44215520
135Selenocompound metabolism_Homo sapiens_hsa004500.44201646
136Prion diseases_Homo sapiens_hsa050200.43705015
137Acute myeloid leukemia_Homo sapiens_hsa052210.42494885
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.41715861
139Lysosome_Homo sapiens_hsa041420.41671174
140Tyrosine metabolism_Homo sapiens_hsa003500.41058062
141Histidine metabolism_Homo sapiens_hsa003400.40970665
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39324321
143Fatty acid degradation_Homo sapiens_hsa000710.39066764
144Choline metabolism in cancer_Homo sapiens_hsa052310.37428846
145Viral carcinogenesis_Homo sapiens_hsa052030.36045839
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.34755409

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