FZD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)5.40715872
2establishment of integrated proviral latency (GO:0075713)4.49201726
3polarized epithelial cell differentiation (GO:0030859)4.41494272
4planar cell polarity pathway involved in neural tube closure (GO:0090179)4.35227008
5convergent extension (GO:0060026)4.31755285
6outer ear morphogenesis (GO:0042473)4.20155473
7protein complex localization (GO:0031503)4.15309632
8regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.14540688
9regulation of gene silencing by RNA (GO:0060966)4.10373277
10regulation of posttranscriptional gene silencing (GO:0060147)4.10373277
11regulation of gene silencing by miRNA (GO:0060964)4.10373277
12desmosome organization (GO:0002934)4.01120028
13positive regulation of SMAD protein import into nucleus (GO:0060391)3.87749668
14hippo signaling (GO:0035329)3.86534261
15protein localization to kinetochore (GO:0034501)3.83572122
16establishment of apical/basal cell polarity (GO:0035089)3.82435216
17hemidesmosome assembly (GO:0031581)3.72961487
18chromatin remodeling at centromere (GO:0031055)3.63459222
19L-serine metabolic process (GO:0006563)3.63295280
20regulation of SMAD protein import into nucleus (GO:0060390)3.55196601
21CENP-A containing nucleosome assembly (GO:0034080)3.53701560
22negative regulation of chondrocyte differentiation (GO:0032331)3.46101188
23regulation of hippo signaling (GO:0035330)3.45905099
24cellular protein complex localization (GO:0034629)3.44494892
25notochord development (GO:0030903)3.42554068
26regulation of heart morphogenesis (GO:2000826)3.42212765
27positive regulation of catenin import into nucleus (GO:0035413)3.32081741
28regulation of mesoderm development (GO:2000380)3.31079647
29establishment of viral latency (GO:0019043)3.25249812
30mitotic metaphase plate congression (GO:0007080)3.25209137
31pre-miRNA processing (GO:0031054)3.24651707
32DNA unwinding involved in DNA replication (GO:0006268)3.23135938
33anterior/posterior axis specification, embryo (GO:0008595)3.22977678
34nuclear pore organization (GO:0006999)3.22120567
35cranial suture morphogenesis (GO:0060363)3.21541368
36endocardial cushion development (GO:0003197)3.17792343
37nuclear pore complex assembly (GO:0051292)3.11857603
38histone exchange (GO:0043486)3.11747172
39protein localization to chromosome, centromeric region (GO:0071459)3.10824143
40negative regulation of androgen receptor signaling pathway (GO:0060766)3.10442311
41DNA replication-independent nucleosome assembly (GO:0006336)3.09583754
42DNA replication-independent nucleosome organization (GO:0034724)3.09583754
43craniofacial suture morphogenesis (GO:0097094)3.08201268
44endodermal cell differentiation (GO:0035987)3.07282779
45mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.05490275
46establishment or maintenance of monopolar cell polarity (GO:0061339)3.05313807
47establishment of monopolar cell polarity (GO:0061162)3.05313807
48epithelial cell-cell adhesion (GO:0090136)3.00761783
49wound healing, spreading of epidermal cells (GO:0035313)3.00749948
50regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.00421576
51regulation of helicase activity (GO:0051095)2.99362329
52* G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.99264638
53primitive streak formation (GO:0090009)2.98727499
54heterochromatin organization (GO:0070828)2.98146422
55inner ear receptor cell development (GO:0060119)2.94566174
56regulation of gene silencing (GO:0060968)2.93475185
57gastrulation with mouth forming second (GO:0001702)2.92418764
58basement membrane organization (GO:0071711)2.91100720
59female gonad development (GO:0008585)2.90745145
60negative regulation of cartilage development (GO:0061037)2.89748984
61regulation of stem cell maintenance (GO:2000036)2.87587532
62branching involved in salivary gland morphogenesis (GO:0060445)2.87381829
63collagen fibril organization (GO:0030199)2.86394804
64DNA replication checkpoint (GO:0000076)2.85972065
65negative regulation of fibroblast apoptotic process (GO:2000270)2.85846601
66IMP biosynthetic process (GO:0006188)2.85641134
67regulation of histone H3-K9 methylation (GO:0051570)2.85172309
68cochlea morphogenesis (GO:0090103)2.84661906
69Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.84644029
70lung-associated mesenchyme development (GO:0060484)2.84513612
71ATP-dependent chromatin remodeling (GO:0043044)2.83688111
72cell migration involved in sprouting angiogenesis (GO:0002042)2.82901340
73negative regulation of translation, ncRNA-mediated (GO:0040033)2.80644062
74regulation of translation, ncRNA-mediated (GO:0045974)2.80644062
75negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.80644062
76skin morphogenesis (GO:0043589)2.79425386
77positive regulation of endothelial cell apoptotic process (GO:2000353)2.79410632
78regulation of establishment of planar polarity (GO:0090175)2.78599441
79regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.77773828
80cell-substrate junction assembly (GO:0007044)2.76202148
81cell fate commitment involved in formation of primary germ layer (GO:0060795)2.74051534
82IMP metabolic process (GO:0046040)2.73283603
83regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.73138882
84chondrocyte proliferation (GO:0035988)2.72777889
85generation of neurons (GO:0048699)2.72049182
86lateral sprouting from an epithelium (GO:0060601)2.71983027
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.71418875
88negative regulation of mitotic sister chromatid segregation (GO:0033048)2.71418875
89negative regulation of mitotic sister chromatid separation (GO:2000816)2.71418875
90negative regulation of sister chromatid segregation (GO:0033046)2.71418875
91negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.71418875
92DNA replication-dependent nucleosome assembly (GO:0006335)2.70998335
93DNA replication-dependent nucleosome organization (GO:0034723)2.70998335
94bone trabecula formation (GO:0060346)2.70466180
95negative regulation of chromosome segregation (GO:0051985)2.69651333
96cell surface receptor signaling pathway involved in heart development (GO:0061311)2.68997021
97endothelial cell morphogenesis (GO:0001886)2.68357848
98mesenchyme development (GO:0060485)2.67657774
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.67382296
100dorsal/ventral axis specification (GO:0009950)2.67380040
101regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.67007464
102positive regulation of epithelial to mesenchymal transition (GO:0010718)2.66769116
103cell adhesion mediated by integrin (GO:0033627)2.66637421
104regulation of transforming growth factor beta2 production (GO:0032909)2.66597171
105metaphase plate congression (GO:0051310)2.66437277
106regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.66037170
107embryonic camera-type eye development (GO:0031076)2.65837404
108DNA strand elongation involved in DNA replication (GO:0006271)2.65617115
109epithelial cell differentiation involved in prostate gland development (GO:0060742)2.65353163
110anatomical structure regression (GO:0060033)2.64624318
111neural tube closure (GO:0001843)2.64580579
112cell migration involved in gastrulation (GO:0042074)2.64377967
113L-alpha-amino acid transmembrane transport (GO:1902475)2.63675427
114glomerular visceral epithelial cell development (GO:0072015)2.63136927
115regulation of hair follicle development (GO:0051797)2.63089031
116histone arginine methylation (GO:0034969)2.62642046
117tube closure (GO:0060606)2.62404661
118negative regulation of DNA repair (GO:0045738)2.61646569
119negative regulation of catenin import into nucleus (GO:0035414)2.60953447
120mitotic sister chromatid cohesion (GO:0007064)2.60810382
121bone morphogenesis (GO:0060349)2.58632577
122negative regulation of fatty acid transport (GO:2000192)2.58624954
123ventricular cardiac muscle cell development (GO:0055015)2.58552345
124regulation of secondary heart field cardioblast proliferation (GO:0003266)2.58511922
125regulation of cardioblast proliferation (GO:0003264)2.58511922
126epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.58456192
127negative regulation of gene silencing (GO:0060969)2.58418607
128DNA strand elongation (GO:0022616)2.58319957
129pattern specification involved in kidney development (GO:0061004)2.58101468
130trophectodermal cell differentiation (GO:0001829)2.57870027
131regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.57867687
132digestive tract morphogenesis (GO:0048546)2.57147062
133anterior/posterior axis specification (GO:0009948)2.56522525
134positive regulation of cardiac muscle cell proliferation (GO:0060045)2.56273809
135negative regulation of cardiac muscle tissue development (GO:0055026)2.54498869
136mesenchymal cell proliferation (GO:0010463)2.53891730
137* regulation of cell fate commitment (GO:0010453)2.52735505
138nodal signaling pathway (GO:0038092)2.51502848
139embryonic cranial skeleton morphogenesis (GO:0048701)2.50779720
140* non-canonical Wnt signaling pathway (GO:0035567)2.50652714
141regulation of non-canonical Wnt signaling pathway (GO:2000050)2.49891217
142regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.47189186
143aorta morphogenesis (GO:0035909)2.46679417
144NLS-bearing protein import into nucleus (GO:0006607)2.45413118
145organ induction (GO:0001759)2.45147218
146middle ear morphogenesis (GO:0042474)2.45069597
147mRNA stabilization (GO:0048255)2.45067489
148RNA stabilization (GO:0043489)2.45067489
149midgut development (GO:0007494)2.45024675
150adherens junction assembly (GO:0034333)2.43564614
151regulation of sister chromatid cohesion (GO:0007063)2.43423259
152establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.42291634
153apoptotic process involved in morphogenesis (GO:0060561)2.41115836
154wound healing, spreading of cells (GO:0044319)2.40438812
155embryonic foregut morphogenesis (GO:0048617)2.40429606
156blood vessel endothelial cell migration (GO:0043534)2.40065767
157positive regulation of mesenchymal cell proliferation (GO:0002053)2.39889278
158axon extension involved in axon guidance (GO:0048846)2.39729552
159neuron projection extension involved in neuron projection guidance (GO:1902284)2.39729552
160negative regulation of keratinocyte proliferation (GO:0010839)2.37495855
161keratinocyte proliferation (GO:0043616)2.37167391
162* regulation of cell fate specification (GO:0042659)2.36154213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.85518349
2E2F7_22180533_ChIP-Seq_HELA_Human4.31815488
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.44953177
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.38244484
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.37930881
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.37773968
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.84670389
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.84670389
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.84670389
10POU5F1_16153702_ChIP-ChIP_HESCs_Human2.76083358
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.39127275
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.36150040
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.35706194
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.33288282
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.32821302
16CLOCK_20551151_ChIP-Seq_293T_Human2.31984831
17* SOX2_16153702_ChIP-ChIP_HESCs_Human2.24001812
18ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.23674374
19* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.22760638
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.21342898
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18422829
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.17691061
23ESR1_21235772_ChIP-Seq_MCF-7_Human2.04849791
24AR_21909140_ChIP-Seq_LNCAP_Human1.99118993
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.97843590
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94786575
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.87469464
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83200384
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.80877555
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.78614892
31* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.77904987
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.77776019
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77206880
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.74535493
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.74476883
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72829179
37* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.72730944
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.72515162
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68678118
40* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.66702967
41ZNF263_19887448_ChIP-Seq_K562_Human1.64844636
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.64088283
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.63226616
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62627216
45SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.60148371
46SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.59552467
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.59552467
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59537118
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.55607373
50ATF3_27146783_Chip-Seq_COLON_Human1.55456969
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54642931
52* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52991967
53DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.52216680
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51849403
55SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.51136294
56* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48991308
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48843075
58* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47867856
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47210706
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45848137
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45007783
62* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44773381
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.44758820
64* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43217652
65* ELK3_25401928_ChIP-Seq_HUVEC_Human1.42749597
66E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42669399
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41615456
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40961413
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.40830336
70* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39781519
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39665066
72TBX3_20139965_ChIP-Seq_ESCs_Mouse1.39099479
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39060314
74UBF1/2_26484160_Chip-Seq_HMECs_Human1.38566098
75TBX3_20139965_ChIP-Seq_MESCs_Mouse1.38376818
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38345040
77NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.37678030
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37149232
79RACK7_27058665_Chip-Seq_MCF-7_Human1.35765162
80* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.35022484
81MYC_22102868_ChIP-Seq_BL_Human1.33332798
82SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33062450
83ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.32420960
84BRD4_25478319_ChIP-Seq_HGPS_Human1.31811708
85NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.30944588
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27554303
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27491157
88MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26916933
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26898075
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26252869
91CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26213811
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24694905
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22812415
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21301471
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20542694
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20280164
97* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18790316
98EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18776333
99POU5F1_16518401_ChIP-PET_MESCs_Mouse1.18690510
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18648691
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18628802
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18423706
103GATA6_25053715_ChIP-Seq_YYC3_Human1.17790369
104XRN2_22483619_ChIP-Seq_HELA_Human1.17175532
105TTF2_22483619_ChIP-Seq_HELA_Human1.17054678
106* ISL1_27105846_Chip-Seq_CPCs_Mouse1.15352009
107NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.14346119
108FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14081181
109E2F1_21310950_ChIP-Seq_MCF-7_Human1.13700162
110CHD1_26751641_Chip-Seq_LNCaP_Human1.12927467
111* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12494244
112THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12400908
113HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12009809
114PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10457036
115* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.10146307
116* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.10050562
117SOX17_20123909_ChIP-Seq_XEN_Mouse1.09991108
118* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.08066010
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07939833
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06333792
121* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04801688
122NANOG_21062744_ChIP-ChIP_HESCs_Human1.03774466
123TP53_20018659_ChIP-ChIP_R1E_Mouse1.03365573
124CJUN_26792858_Chip-Seq_BT549_Human1.02808129
125* NANOG_16153702_ChIP-ChIP_HESCs_Human1.02690209
126* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02029292
127* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.01955345
128TCF7_22412390_ChIP-Seq_EML_Mouse1.01678577
129PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01531789
130WT1_19549856_ChIP-ChIP_CCG9911_Human1.01506983
131NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01322471
132* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.00617501
133* ELK1_19687146_ChIP-ChIP_HELA_Human0.99822075
134KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98842846
135* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98723279
136NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98525834
137PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97842944
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97740360
139NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97666568
140* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.95456759
141NANOG_16518401_ChIP-PET_MESCs_Mouse0.94741880
142EST1_17652178_ChIP-ChIP_JURKAT_Human0.93901851
143KAP1_27257070_Chip-Seq_ESCs_Mouse0.92363799
144SMAD3_21741376_ChIP-Seq_HESCs_Human0.90120847
145MYC_18940864_ChIP-ChIP_HL60_Human0.89413392
146RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89343710
147CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85031155
148* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82415163
149* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.79176549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.44968762
2MP0010030_abnormal_orbit_morphology3.04808467
3MP0008438_abnormal_cutaneous_collagen2.98338960
4MP0005275_abnormal_skin_tensile2.88315814
5MP0010352_gastrointestinal_tract_polyps2.74659191
6MP0009053_abnormal_anal_canal2.68320694
7MP0003941_abnormal_skin_development2.64139143
8MP0010234_abnormal_vibrissa_follicle2.55344180
9MP0000537_abnormal_urethra_morphology2.55033020
10MP0003566_abnormal_cell_adhesion2.29701205
11MP0003693_abnormal_embryo_hatching2.24615260
12MP0009672_abnormal_birth_weight2.19497489
13MP0005076_abnormal_cell_differentiation2.06981678
14MP0006292_abnormal_olfactory_placode2.06266813
15MP0005623_abnormal_meninges_morphology2.06001291
16MP0004272_abnormal_basement_membrane2.04504577
17MP0008932_abnormal_embryonic_tissue2.00395695
18MP0003111_abnormal_nucleus_morphology1.98884786
19MP0002249_abnormal_larynx_morphology1.87917706
20MP0001849_ear_inflammation1.87044784
21MP0000516_abnormal_urinary_system1.83347939
22MP0005367_renal/urinary_system_phenotyp1.83347939
23MP0002254_reproductive_system_inflammat1.73023013
24MP0002060_abnormal_skin_morphology1.71084648
25MP0003136_yellow_coat_color1.70066737
26MP0005503_abnormal_tendon_morphology1.69605495
27MP0010094_abnormal_chromosome_stability1.67590278
28MP0002796_impaired_skin_barrier1.64714182
29MP0005023_abnormal_wound_healing1.59904016
30MP0003385_abnormal_body_wall1.58737604
31MP0000733_abnormal_muscle_development1.56497989
32MP0002098_abnormal_vibrissa_morphology1.51915222
33MP0009384_cardiac_valve_regurgitation1.51342803
34MP0002282_abnormal_trachea_morphology1.51337021
35MP0000579_abnormal_nail_morphology1.50526998
36MP0000762_abnormal_tongue_morphology1.45314523
37MP0005508_abnormal_skeleton_morphology1.44143506
38MP0003077_abnormal_cell_cycle1.42559797
39MP0003937_abnormal_limbs/digits/tail_de1.42427849
40MP0000428_abnormal_craniofacial_morphol1.42206805
41MP0005257_abnormal_intraocular_pressure1.42110119
42MP0003942_abnormal_urinary_system1.40751837
43MP0000534_abnormal_ureter_morphology1.38917998
44MP0000566_synostosis1.38705811
45MP0003755_abnormal_palate_morphology1.37498300
46MP0003453_abnormal_keratinocyte_physiol1.36196911
47MP0004197_abnormal_fetal_growth/weight/1.34180768
48MP0002697_abnormal_eye_size1.34062943
49MP0009703_decreased_birth_body1.33201987
50MP0006054_spinal_hemorrhage1.32087446
51MP0003119_abnormal_digestive_system1.30219710
52MP0009250_abnormal_appendicular_skeleto1.30165972
53MP0001293_anophthalmia1.30156634
54MP0005248_abnormal_Harderian_gland1.29190794
55MP0002084_abnormal_developmental_patter1.28623157
56MP0000432_abnormal_head_morphology1.28252284
57MP0000049_abnormal_middle_ear1.28225328
58MP0002938_white_spotting1.28071558
59MP0002932_abnormal_joint_morphology1.27970297
60MP0005501_abnormal_skin_physiology1.25486306
61MP0010678_abnormal_skin_adnexa1.25425281
62MP0003935_abnormal_craniofacial_develop1.24573560
63MP0003115_abnormal_respiratory_system1.21769674
64MP0002111_abnormal_tail_morphology1.21484102
65MP0002233_abnormal_nose_morphology1.20728583
66MP0008057_abnormal_DNA_replication1.19809530
67MP0000467_abnormal_esophagus_morphology1.18969435
68MP0000377_abnormal_hair_follicle1.18028739
69MP0003890_abnormal_embryonic-extraembry1.17926589
70MP0003279_aneurysm1.17693605
71MP0003567_abnormal_fetal_cardiomyocyte1.16443477
72MP0002092_abnormal_eye_morphology1.16413682
73MP0002085_abnormal_embryonic_tissue1.16124922
74MP0003861_abnormal_nervous_system1.15020321
75MP0000383_abnormal_hair_follicle1.11163327
76MP0001346_abnormal_lacrimal_gland1.09084824
77MP0004957_abnormal_blastocyst_morpholog1.07808980
78MP0010307_abnormal_tumor_latency1.06921983
79MP0008058_abnormal_DNA_repair1.05798883
80MP0001188_hyperpigmentation1.02852811
81MP0001216_abnormal_epidermal_layer1.02803177
82MP0001243_abnormal_dermal_layer1.01472906
83MP0009379_abnormal_foot_pigmentation1.01030933
84MP0001730_embryonic_growth_arrest1.00558390
85MP0002086_abnormal_extraembryonic_tissu1.00399763
86MP0003718_maternal_effect1.00272859
87MP0004858_abnormal_nervous_system0.99244347
88MP0002234_abnormal_pharynx_morphology0.99028776
89MP0003123_paternal_imprinting0.98622552
90MP0002080_prenatal_lethality0.98214527
91MP0001958_emphysema0.97167189
92MP0000462_abnormal_digestive_system0.97083637
93MP0005380_embryogenesis_phenotype0.96896143
94MP0001672_abnormal_embryogenesis/_devel0.96896143
95MP0000350_abnormal_cell_proliferation0.96880153
96MP0001340_abnormal_eyelid_morphology0.96577722
97MP0001915_intracranial_hemorrhage0.96415785
98MP0002896_abnormal_bone_mineralization0.95014960
99MP0001299_abnormal_eye_distance/0.93932867
100MP0004185_abnormal_adipocyte_glucose0.92948175
101MP0002088_abnormal_embryonic_growth/wei0.92795334
102MP0001286_abnormal_eye_development0.92324515
103MP0002116_abnormal_craniofacial_bone0.92232767
104MP0002925_abnormal_cardiovascular_devel0.92202518
105MP0005377_hearing/vestibular/ear_phenot0.92060603
106MP0003878_abnormal_ear_physiology0.92060603
107MP0003984_embryonic_growth_retardation0.91066412
108MP0000163_abnormal_cartilage_morphology0.90717683
109MP0001697_abnormal_embryo_size0.90624572
110MP0005187_abnormal_penis_morphology0.90513408
111MP0000767_abnormal_smooth_muscle0.90385998
112MP0010368_abnormal_lymphatic_system0.90177312
113MP0000647_abnormal_sebaceous_gland0.89402651
114MP0003283_abnormal_digestive_organ0.88688673
115MP0000751_myopathy0.88673581
116MP0003091_abnormal_cell_migration0.87404755
117MP0003938_abnormal_ear_development0.85292207
118MP0001177_atelectasis0.84338067
119MP0002114_abnormal_axial_skeleton0.83290095
120MP0002109_abnormal_limb_morphology0.82696352
121MP0002081_perinatal_lethality0.82059400
122MP0004133_heterotaxia0.81567527
123MP0000427_abnormal_hair_cycle0.80794113
124MP0001529_abnormal_vocalization0.80721394
125MP0002089_abnormal_postnatal_growth/wei0.80596412
126MP0008877_abnormal_DNA_methylation0.78629238
127MP0002115_abnormal_skeleton_extremities0.78363985
128MP0002177_abnormal_outer_ear0.78303123
129MP0000678_abnormal_parathyroid_gland0.78160151
130MP0005197_abnormal_uvea_morphology0.77249965
131MP0005394_taste/olfaction_phenotype0.75934434
132MP0005499_abnormal_olfactory_system0.75934434
133MP0002751_abnormal_autonomic_nervous0.74736467
134MP0008007_abnormal_cellular_replicative0.73764020
135MP0002108_abnormal_muscle_morphology0.70538403

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)4.44936692
2Shallow orbits (HP:0000586)4.33918658
3Protrusio acetabuli (HP:0003179)4.23446189
4Premature rupture of membranes (HP:0001788)3.65687985
5Atrophic scars (HP:0001075)3.33816607
6Partial duplication of thumb phalanx (HP:0009944)3.23560674
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.17334049
8Short 4th metacarpal (HP:0010044)3.17334049
9Partial duplication of the phalanx of hand (HP:0009999)3.12501434
10Choanal stenosis (HP:0000452)2.98766043
11Ankle contracture (HP:0006466)2.96775163
12Right ventricular cardiomyopathy (HP:0011663)2.87866782
13Short hallux (HP:0010109)2.81780103
14Selective tooth agenesis (HP:0001592)2.78224312
15Maternal diabetes (HP:0009800)2.76989541
16Abnormality of the 4th metacarpal (HP:0010012)2.59847577
17Aplasia/Hypoplasia of the hallux (HP:0008362)2.57983527
18Absent septum pellucidum (HP:0001331)2.56693667
19Broad metatarsal (HP:0001783)2.54958719
20Hepatoblastoma (HP:0002884)2.52838014
21Bilateral microphthalmos (HP:0007633)2.49845093
22Preaxial foot polydactyly (HP:0001841)2.46666180
23Cerebral aneurysm (HP:0004944)2.45451180
24Abnormality of the septum pellucidum (HP:0007375)2.43063091
25Cortical dysplasia (HP:0002539)2.43051292
26Abnormal lung lobation (HP:0002101)2.41248049
27Abnormality of the labia minora (HP:0012880)2.38465112
28Aortic dissection (HP:0002647)2.37935436
29Milia (HP:0001056)2.35203953
30Bifid tongue (HP:0010297)2.34819206
31Peritonitis (HP:0002586)2.33702701
32Duplication of thumb phalanx (HP:0009942)2.29277231
33Myelomeningocele (HP:0002475)2.28462823
34Breast aplasia (HP:0100783)2.27260869
35Mitral valve prolapse (HP:0001634)2.26897941
36Abdominal situs inversus (HP:0003363)2.24471814
37Abnormality of abdominal situs (HP:0011620)2.24471814
38Short middle phalanx of the 5th finger (HP:0004220)2.23523642
39Increased connective tissue (HP:0009025)2.22430668
40Aplasia/Hypoplasia of the breasts (HP:0010311)2.21904110
41Hypoplastic labia majora (HP:0000059)2.19572170
42Embryonal renal neoplasm (HP:0011794)2.16538646
43Abnormality of dentin (HP:0010299)2.15477585
44Round ear (HP:0100830)2.13116788
45Type 1 muscle fiber predominance (HP:0003803)2.12133627
46Aortic aneurysm (HP:0004942)2.12117392
47Renal duplication (HP:0000075)2.11711577
48Fragile skin (HP:0001030)2.11447030
49Turricephaly (HP:0000262)2.11396071
50Aplasia involving bones of the extremities (HP:0009825)2.10137323
51Aplasia involving bones of the upper limbs (HP:0009823)2.10137323
52Aplasia of the phalanges of the hand (HP:0009802)2.10137323
53Genu recurvatum (HP:0002816)2.09656890
54Bladder diverticulum (HP:0000015)2.07860395
55Nephroblastoma (Wilms tumor) (HP:0002667)2.07628981
56Abnormality of the middle phalanges of the toes (HP:0010183)2.06952328
57Pili torti (HP:0003777)2.06732352
58Aqueductal stenosis (HP:0002410)2.06162282
59Natal tooth (HP:0000695)2.05721820
60Ulnar bowing (HP:0003031)2.05602136
61Anophthalmia (HP:0000528)2.04788584
62Broad thumb (HP:0011304)2.03365166
63Neonatal short-limb short stature (HP:0008921)2.03229785
64Arnold-Chiari malformation (HP:0002308)2.02592656
65Broad finger (HP:0001500)2.02588902
66Abnormality of the labia majora (HP:0012881)2.01875893
67Blue sclerae (HP:0000592)2.01416670
68Camptodactyly of toe (HP:0001836)2.01270326
69Wrist flexion contracture (HP:0001239)2.00315929
70Fused cervical vertebrae (HP:0002949)1.99884883
71Coronal craniosynostosis (HP:0004440)1.99589310
72Abnormality of the distal phalanx of the thumb (HP:0009617)1.98972697
73Lip pit (HP:0100267)1.98864498
74Broad phalanx (HP:0006009)1.98859303
75Cutaneous syndactyly (HP:0012725)1.98552341
76Increased nuchal translucency (HP:0010880)1.98224749
77Abnormal number of incisors (HP:0011064)1.97916612
78Rectovaginal fistula (HP:0000143)1.97590274
79Rectal fistula (HP:0100590)1.97590274
80Supernumerary ribs (HP:0005815)1.96852005
81Soft skin (HP:0000977)1.96267896
82Pseudobulbar signs (HP:0002200)1.96232615
83Deviation of the hallux (HP:0010051)1.96015927
84Cervical subluxation (HP:0003308)1.95367640
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95145572
86Deviation of the thumb (HP:0009603)1.93825690
87Optic nerve hypoplasia (HP:0000609)1.91490365
88Esophageal atresia (HP:0002032)1.91010104
89Meckel diverticulum (HP:0002245)1.90007736
90Abnormality of the calcaneus (HP:0008364)1.89966253
91Abnormality of the lacrimal duct (HP:0011481)1.89559962
92Absent radius (HP:0003974)1.89477330
93Intestinal atresia (HP:0011100)1.87053235
94Colon cancer (HP:0003003)1.86368422
95Missing ribs (HP:0000921)1.85700683
96Dilatation of the ascending aorta (HP:0005111)1.84559173
97Hypotrichosis (HP:0001006)1.82941252
98Scapular winging (HP:0003691)1.82906949
99Abnormality of the fetal cardiovascular system (HP:0010948)1.82854670
100Abnormal umbilical cord blood vessels (HP:0011403)1.82854670
101Single umbilical artery (HP:0001195)1.82854670
102Down-sloping shoulders (HP:0200021)1.82330263
103Mesomelia (HP:0003027)1.81892126
104Hallux valgus (HP:0001822)1.81151786
105Ependymoma (HP:0002888)1.81083674
106Tibial bowing (HP:0002982)1.80408164
107Cutaneous finger syndactyly (HP:0010554)1.79128418
108Short middle phalanx of finger (HP:0005819)1.78947477
109Aplasia/Hypoplasia of the sternum (HP:0006714)1.78441884
110Advanced eruption of teeth (HP:0006288)1.78279370
111Wide anterior fontanel (HP:0000260)1.78020235
112Trigonocephaly (HP:0000243)1.77057400
113Bronchomalacia (HP:0002780)1.76802582
114Rectal prolapse (HP:0002035)1.76543207
115Absent forearm bone (HP:0003953)1.75838326
116Aplasia involving forearm bones (HP:0009822)1.75838326
117Vaginal fistula (HP:0004320)1.75766555
118Abnormality of the nasal septum (HP:0000419)1.75093015
119Abnormality of the nasolacrimal system (HP:0000614)1.75075664
120Tarsal synostosis (HP:0008368)1.74762469
121Skin tags (HP:0010609)1.74649561
122Biliary tract neoplasm (HP:0100574)1.74287574
123Abnormality of the umbilical cord (HP:0010881)1.74101560
124Absent toe (HP:0010760)1.73418963
125Skull defect (HP:0001362)1.73409081
126Abnormality of the peritoneum (HP:0002585)1.72961168
127Abnormality of the ileum (HP:0001549)1.72166986
128Hemivertebrae (HP:0002937)1.72088732
129Vertebral fusion (HP:0002948)1.71637794
130Anal stenosis (HP:0002025)1.71356087
131Proximal placement of thumb (HP:0009623)1.71271823
132Spinal rigidity (HP:0003306)1.70444388
133Short humerus (HP:0005792)1.70018647
134Gastrointestinal atresia (HP:0002589)1.69921377
135Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.69668941
136Radial bowing (HP:0002986)1.69644376
137Gastrointestinal carcinoma (HP:0002672)1.69381016
138Malignant gastrointestinal tract tumors (HP:0006749)1.69381016
139Supernumerary bones of the axial skeleton (HP:0009144)1.69172980
140Aneurysm (HP:0002617)1.69156447
141Rocker bottom foot (HP:0001838)1.68648869
142Increased density of long bones (HP:0006392)1.68435270
143Woolly hair (HP:0002224)1.67979754
144Intestinal fistula (HP:0100819)1.67185545
145Morphological abnormality of the middle ear (HP:0008609)1.67028670
146Oligodontia (HP:0000677)1.67013471
147Preauricular skin tag (HP:0000384)1.66960657
148Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.65776895
149Calcaneovalgus deformity (HP:0001848)1.65369274
150Broad toe (HP:0001837)1.65098838
151Abnormality of the parietal bone (HP:0002696)1.64983470
152Bowel diverticulosis (HP:0005222)1.64511336
153Synostosis involving bones of the lower limbs (HP:0009138)1.64358296
154Synostosis involving bones of the feet (HP:0009140)1.64358296
155Facial cleft (HP:0002006)1.63489025
156Bowing of the arm (HP:0006488)1.63446255
157Bowed forearm bones (HP:0003956)1.63446255
158Birth length less than 3rd percentile (HP:0003561)1.63114706
159Broad long bones (HP:0005622)1.62591795
160Trismus (HP:0000211)1.62473053
161Omphalocele (HP:0001539)1.62277921
162Spastic diplegia (HP:0001264)1.61983632
163Thin bony cortex (HP:0002753)1.61169093
164Syringomyelia (HP:0003396)1.61067697
165Spinal cord lesions (HP:0100561)1.61067697
166Synostosis of carpal bones (HP:0005048)1.60885057
167Elbow flexion contracture (HP:0002987)1.60836610
168Absent eyelashes (HP:0000561)1.60399475
169Aplasia/hypoplasia of the humerus (HP:0006507)1.60250544
170Wormian bones (HP:0002645)1.59402154
171Knee flexion contracture (HP:0006380)1.59320851
172Broad phalanges of the hand (HP:0009768)1.58621243
173Skin pits (HP:0100276)1.57041458

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.42294079
2EPHB23.17280884
3TTN3.07490646
4CDK122.98277195
5LATS22.90473968
6TAF12.87325622
7BUB12.85317539
8VRK22.84744051
9MKNK22.62513678
10TNIK2.60222957
11PKN22.58897183
12EPHA22.52078588
13TRIB32.44563602
14SIK12.36314910
15DDR22.25707215
16EEF2K2.14665502
17MAP3K102.05636502
18SRPK12.05609324
19PDGFRA2.05051801
20PTK61.97062046
21RIPK11.93872397
22PLK41.81760489
23STK31.79753151
24PNCK1.76565628
25CDK61.75018203
26ERN11.65832941
27RPS6KB21.65600349
28PAK41.62929650
29SMG11.62743228
30BMX1.55984385
31MET1.55101344
32STK38L1.54562510
33CDC71.52018620
34MTOR1.43966205
35BRSK21.41600140
36FGFR11.40329716
37DYRK21.37918446
38FER1.36009329
39PAK21.33944248
40LRRK21.32337854
41PTK21.32036816
42NEK21.25198451
43FLT31.24482834
44NTRK11.24480687
45RPS6KA41.24061482
46TTK1.16868291
47ZAK1.16040497
48STK101.11850260
49CDK191.11484003
50VRK11.06536196
51MAP3K91.03065582
52CAMK1D1.01705385
53NEK11.00880998
54TGFBR11.00379814
55MYLK0.99358716
56MAP3K30.98812775
57MAP3K80.97796360
58TRPM70.97502880
59EPHA30.97380013
60ERBB20.96929031
61CDK70.96041136
62ERBB40.93383528
63NEK90.92718369
64PASK0.91185994
65BRD40.90615943
66NUAK10.89021120
67FGFR20.88434828
68MAP2K30.88042554
69MKNK10.83751550
70CDK40.83310934
71MAPKAPK30.82863560
72PDGFRB0.82317640
73TYRO30.82138342
74DMPK0.81216332
75ICK0.80918460
76WNK30.79192285
77AURKB0.77885864
78STK240.74442995
79ERBB30.71538421
80BCR0.70678722
81ALK0.70664992
82FGFR40.70462842
83WEE10.69998791
84NLK0.68657875
85DYRK30.68216129
86MST1R0.67093148
87EIF2AK20.63927289
88EPHB10.63178351
89BRSK10.62085771
90DYRK1B0.61416438
91NME10.60917285
92STK40.59094918
93CSNK1G10.57079967
94TRIM280.56681595
95CHUK0.55891396
96AKT20.55270271
97TGFBR20.54758078
98CHEK10.53585649
99CASK0.53390262
100BMPR1B0.52862421
101SCYL20.52641685
102CAMK1G0.52486002
103MST40.51976236
104ROCK20.51722362
105PLK20.51447156
106AKT30.49897663
107GSK3A0.49733741
108TSSK60.48852219
109PRKDC0.48538573
110CDK10.48200108
111CDK20.47083387
112ATM0.46918190
113PLK10.46602378
114ATR0.46097231
115ILK0.45681458
116BRAF0.43866482
117AURKA0.43647900
118MAPK10.43622293
119PRKG20.42548800
120RPS6KA10.41485506
121CSNK1D0.39325958
122MELK0.38297055
123PLK30.37532935
124EPHA40.36334093
125CSNK1E0.36263503
126PBK0.36069365
127TIE10.35829295
128MAP3K20.35805691
129PAK10.35627140
130STK160.35093218
131PIK3CG0.34846838
132INSR0.34396886
133RET0.34386936
134CDK11A0.33525435
135CDK150.33482550
136DAPK30.33362726
137CDK180.33341932
138FGFR30.32473929
139CHEK20.31308883
140AKT10.31096755
141ROCK10.30497537
142RPS6KC10.30185413
143RPS6KL10.30185413
144TESK10.29742515
145PIM10.29635318
146ACVR1B0.28971205

Predicted pathways (KEGG)

RankGene SetZ-score
1* Basal cell carcinoma_Homo sapiens_hsa052172.91091998
2Adherens junction_Homo sapiens_hsa045202.74295093
3* Hippo signaling pathway_Homo sapiens_hsa043902.58864112
4ECM-receptor interaction_Homo sapiens_hsa045122.58428447
5TGF-beta signaling pathway_Homo sapiens_hsa043502.36852594
6* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.15520184
7Non-homologous end-joining_Homo sapiens_hsa034502.14179718
8MicroRNAs in cancer_Homo sapiens_hsa052062.13567771
9* Proteoglycans in cancer_Homo sapiens_hsa052052.10938516
10Hedgehog signaling pathway_Homo sapiens_hsa043402.06787248
11Bladder cancer_Homo sapiens_hsa052192.02199683
12One carbon pool by folate_Homo sapiens_hsa006701.94126960
13Focal adhesion_Homo sapiens_hsa045101.92241299
14Small cell lung cancer_Homo sapiens_hsa052221.89729073
15Ribosome_Homo sapiens_hsa030101.79187715
16RNA polymerase_Homo sapiens_hsa030201.73131640
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.72356847
18Base excision repair_Homo sapiens_hsa034101.66825434
19Proteasome_Homo sapiens_hsa030501.63561634
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.60616106
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58160324
22Amoebiasis_Homo sapiens_hsa051461.55631103
23p53 signaling pathway_Homo sapiens_hsa041151.53944300
24Tight junction_Homo sapiens_hsa045301.53664947
25Nitrogen metabolism_Homo sapiens_hsa009101.53151953
26Homologous recombination_Homo sapiens_hsa034401.51487318
27Lysine degradation_Homo sapiens_hsa003101.49386540
28Notch signaling pathway_Homo sapiens_hsa043301.49202047
29Nucleotide excision repair_Homo sapiens_hsa034201.47807071
30Basal transcription factors_Homo sapiens_hsa030221.46716736
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42035020
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.41725737
33Chronic myeloid leukemia_Homo sapiens_hsa052201.37940466
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37626089
35Thyroid cancer_Homo sapiens_hsa052161.35961729
36RNA transport_Homo sapiens_hsa030131.35839384
37Cell cycle_Homo sapiens_hsa041101.35116124
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.28948939
39Vitamin B6 metabolism_Homo sapiens_hsa007501.26752190
40Melanoma_Homo sapiens_hsa052181.21870369
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.21351117
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20049861
43Protein export_Homo sapiens_hsa030601.16330055
44Selenocompound metabolism_Homo sapiens_hsa004501.16101885
45Steroid biosynthesis_Homo sapiens_hsa001001.14930233
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.14527903
47Fanconi anemia pathway_Homo sapiens_hsa034601.13665088
48* Pathways in cancer_Homo sapiens_hsa052001.13043564
49Pyruvate metabolism_Homo sapiens_hsa006201.11838139
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10802330
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08838764
52Spliceosome_Homo sapiens_hsa030401.08499097
53Prostate cancer_Homo sapiens_hsa052151.07950445
54* Wnt signaling pathway_Homo sapiens_hsa043101.07053886
55Endometrial cancer_Homo sapiens_hsa052131.02170178
56Viral carcinogenesis_Homo sapiens_hsa052030.99311945
57* HTLV-I infection_Homo sapiens_hsa051660.98611589
58Protein digestion and absorption_Homo sapiens_hsa049740.98165764
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95392773
60mTOR signaling pathway_Homo sapiens_hsa041500.95317431
61PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94779100
62Colorectal cancer_Homo sapiens_hsa052100.94656470
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92390469
64Viral myocarditis_Homo sapiens_hsa054160.90896330
65Insulin resistance_Homo sapiens_hsa049310.90053265
66Systemic lupus erythematosus_Homo sapiens_hsa053220.88077971
67mRNA surveillance pathway_Homo sapiens_hsa030150.84515564
68Oocyte meiosis_Homo sapiens_hsa041140.84077146
69Arginine biosynthesis_Homo sapiens_hsa002200.83760758
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83556215
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83370955
72Complement and coagulation cascades_Homo sapiens_hsa046100.83283018
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82975800
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82049884
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80491898
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79899349
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78966981
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78959385
79Vitamin digestion and absorption_Homo sapiens_hsa049770.78907542
80Mismatch repair_Homo sapiens_hsa034300.78658959
81Pancreatic cancer_Homo sapiens_hsa052120.78648714
82Pyrimidine metabolism_Homo sapiens_hsa002400.76992207
83Carbon metabolism_Homo sapiens_hsa012000.75510921
84Biosynthesis of amino acids_Homo sapiens_hsa012300.74612553
85Caffeine metabolism_Homo sapiens_hsa002320.73835558
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73749887
87Rap1 signaling pathway_Homo sapiens_hsa040150.73424975
88Toxoplasmosis_Homo sapiens_hsa051450.70979486
89DNA replication_Homo sapiens_hsa030300.68690122
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68408561
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67782921
92Purine metabolism_Homo sapiens_hsa002300.67136453
93* Melanogenesis_Homo sapiens_hsa049160.65140972
94Dilated cardiomyopathy_Homo sapiens_hsa054140.64810529
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64792490
96Huntingtons disease_Homo sapiens_hsa050160.63572812
97Malaria_Homo sapiens_hsa051440.62734851
98HIF-1 signaling pathway_Homo sapiens_hsa040660.61089667
99Chemical carcinogenesis_Homo sapiens_hsa052040.60883984
100AMPK signaling pathway_Homo sapiens_hsa041520.59815359
101Retinol metabolism_Homo sapiens_hsa008300.58173648
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57743549
103Propanoate metabolism_Homo sapiens_hsa006400.56421110
104Folate biosynthesis_Homo sapiens_hsa007900.55618338
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55326949
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.55247487
107FoxO signaling pathway_Homo sapiens_hsa040680.55212808
108Renal cell carcinoma_Homo sapiens_hsa052110.55136258
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54532904
110Non-small cell lung cancer_Homo sapiens_hsa052230.54289786
111Acute myeloid leukemia_Homo sapiens_hsa052210.53994703
112Apoptosis_Homo sapiens_hsa042100.53844964
113Cardiac muscle contraction_Homo sapiens_hsa042600.53274738
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53129560
115Glutathione metabolism_Homo sapiens_hsa004800.52650639
116Antigen processing and presentation_Homo sapiens_hsa046120.51704691
117Glioma_Homo sapiens_hsa052140.50995814
118Legionellosis_Homo sapiens_hsa051340.50935555
119Axon guidance_Homo sapiens_hsa043600.49732432
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47442528
121PPAR signaling pathway_Homo sapiens_hsa033200.46992230
122Hepatitis B_Homo sapiens_hsa051610.46914111
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45712165
124Phenylalanine metabolism_Homo sapiens_hsa003600.44786428
125Fatty acid degradation_Homo sapiens_hsa000710.44229564
126Gap junction_Homo sapiens_hsa045400.43443336
127Arginine and proline metabolism_Homo sapiens_hsa003300.42990719
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42763188
129Insulin signaling pathway_Homo sapiens_hsa049100.42703492
130TNF signaling pathway_Homo sapiens_hsa046680.42261314
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42258616
132N-Glycan biosynthesis_Homo sapiens_hsa005100.42205408
133Tyrosine metabolism_Homo sapiens_hsa003500.39296957
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.39158628
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38998576
136Galactose metabolism_Homo sapiens_hsa000520.37769862
137RNA degradation_Homo sapiens_hsa030180.37674428
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37561496
139Fatty acid elongation_Homo sapiens_hsa000620.32957624
140Parkinsons disease_Homo sapiens_hsa050120.31558871
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29067431
142Pentose phosphate pathway_Homo sapiens_hsa000300.28114916
143Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26126295
144Thyroid hormone synthesis_Homo sapiens_hsa049180.26049515

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