FZD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.78641230
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.78641230
3L-phenylalanine metabolic process (GO:0006558)5.64302462
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.64302462
5hemidesmosome assembly (GO:0031581)5.31010168
6axon extension involved in axon guidance (GO:0048846)5.23298446
7neuron projection extension involved in neuron projection guidance (GO:1902284)5.23298446
8prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.09523729
9negative regulation of fibrinolysis (GO:0051918)4.90623057
10aromatic amino acid family catabolic process (GO:0009074)4.74256584
11protein carboxylation (GO:0018214)4.63931863
12peptidyl-glutamic acid carboxylation (GO:0017187)4.63931863
13regulation of fibrinolysis (GO:0051917)4.60776335
14sulfur amino acid catabolic process (GO:0000098)4.58058617
15glyoxylate metabolic process (GO:0046487)4.51731802
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.49572256
17alpha-linolenic acid metabolic process (GO:0036109)4.46145203
18bile acid biosynthetic process (GO:0006699)4.23288235
19urea cycle (GO:0000050)4.13936013
20urea metabolic process (GO:0019627)4.13936013
21positive regulation of fatty acid beta-oxidation (GO:0032000)4.12261777
22high-density lipoprotein particle remodeling (GO:0034375)4.02662863
23convergent extension (GO:0060026)3.98953560
24kynurenine metabolic process (GO:0070189)3.96508182
25ganglion development (GO:0061548)3.91620392
26negative regulation of axon extension involved in axon guidance (GO:0048843)3.90463624
27endothelial cell chemotaxis (GO:0035767)3.89549218
28regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.89117895
29notochord development (GO:0030903)3.86484733
30cysteine metabolic process (GO:0006534)3.86359865
31regulation of protein activation cascade (GO:2000257)3.85487565
32indole-containing compound catabolic process (GO:0042436)3.83841451
33indolalkylamine catabolic process (GO:0046218)3.83841451
34tryptophan catabolic process (GO:0006569)3.83841451
35dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.81557208
36cell migration involved in sprouting angiogenesis (GO:0002042)3.81153148
37nitrogen cycle metabolic process (GO:0071941)3.76375889
38serine family amino acid catabolic process (GO:0009071)3.72575218
39cellular glucuronidation (GO:0052695)3.71965365
40tryptophan metabolic process (GO:0006568)3.69003330
41tyrosine metabolic process (GO:0006570)3.66800213
42Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.66310239
43complement activation, alternative pathway (GO:0006957)3.63304359
44regulation of complement activation (GO:0030449)3.63144691
45retina vasculature morphogenesis in camera-type eye (GO:0061299)3.62031185
46epoxygenase P450 pathway (GO:0019373)3.58876973
47bile acid metabolic process (GO:0008206)3.56888808
48negative regulation of cell fate specification (GO:0009996)3.53635358
49branching involved in prostate gland morphogenesis (GO:0060442)3.53578270
50regulation of establishment of planar polarity (GO:0090175)3.52563189
51homocysteine metabolic process (GO:0050667)3.52259699
52amino-acid betaine metabolic process (GO:0006577)3.48549172
53fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.48459822
54paraxial mesoderm development (GO:0048339)3.47510766
55fibrinolysis (GO:0042730)3.46857882
56acylglycerol homeostasis (GO:0055090)3.46383616
57triglyceride homeostasis (GO:0070328)3.46383616
58reverse cholesterol transport (GO:0043691)3.46173813
59lysine metabolic process (GO:0006553)3.44107552
60lysine catabolic process (GO:0006554)3.44107552
61negative regulation of lipase activity (GO:0060192)3.42884190
62facial nerve structural organization (GO:0021612)3.39283705
63negative regulation of sterol transport (GO:0032372)3.38369018
64negative regulation of cholesterol transport (GO:0032375)3.38369018
65aromatic amino acid family metabolic process (GO:0009072)3.38270202
66regulation of fatty acid beta-oxidation (GO:0031998)3.36359851
67regulation of cholesterol homeostasis (GO:2000188)3.35894367
68alpha-amino acid catabolic process (GO:1901606)3.34727803
69semaphorin-plexin signaling pathway (GO:0071526)3.33093072
70positive regulation of fatty acid oxidation (GO:0046321)3.32933501
71positive regulation of neuroblast proliferation (GO:0002052)3.32371389
72macromolecular complex remodeling (GO:0034367)3.28070235
73plasma lipoprotein particle remodeling (GO:0034369)3.28070235
74protein-lipid complex remodeling (GO:0034368)3.28070235
75cochlea morphogenesis (GO:0090103)3.27909386
76cell-substrate junction assembly (GO:0007044)3.27508275
77cellular modified amino acid catabolic process (GO:0042219)3.26044083
78artery development (GO:0060840)3.26007685
79substrate-dependent cell migration (GO:0006929)3.25330357
80regulation of triglyceride catabolic process (GO:0010896)3.25285574
81G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.25092643
82regulation of cell fate specification (GO:0042659)3.24933280
83plasma lipoprotein particle clearance (GO:0034381)3.24817643
84negative regulation of axon guidance (GO:1902668)3.24213815
85uronic acid metabolic process (GO:0006063)3.24170711
86glucuronate metabolic process (GO:0019585)3.24170711
87regulation of cholesterol esterification (GO:0010872)3.23368552
88coenzyme catabolic process (GO:0009109)3.23091314
89positive regulation of lipid catabolic process (GO:0050996)3.19788730
90negative regulation of chondrocyte differentiation (GO:0032331)3.19344412
91cellular amino acid catabolic process (GO:0009063)3.17900527
92embryonic retina morphogenesis in camera-type eye (GO:0060059)3.17734059
93arginine metabolic process (GO:0006525)3.17718487
94non-canonical Wnt signaling pathway (GO:0035567)3.17617749
95tongue development (GO:0043586)3.15074038
96regulation of plasminogen activation (GO:0010755)3.13397392
97midgut development (GO:0007494)3.09749274
98planar cell polarity pathway involved in neural tube closure (GO:0090179)3.09069973
99axon extension (GO:0048675)3.08627750
100cellular ketone body metabolic process (GO:0046950)3.06455027
101phospholipid efflux (GO:0033700)3.06007362
102neural tube development (GO:0021915)3.05322943
103endodermal cell differentiation (GO:0035987)3.05187321
104glycine metabolic process (GO:0006544)3.04597806
105adherens junction assembly (GO:0034333)3.04195470
106glutamate metabolic process (GO:0006536)3.02690590
107regulation of axon extension involved in axon guidance (GO:0048841)3.02596063
108cholesterol efflux (GO:0033344)3.01460286
109bile acid and bile salt transport (GO:0015721)3.00509954
110regulation of glomerular filtration (GO:0003093)3.00361902
111atrioventricular valve morphogenesis (GO:0003181)2.98895806
112imidazole-containing compound metabolic process (GO:0052803)2.96839310
113ethanol oxidation (GO:0006069)2.94750255
114acetyl-CoA metabolic process (GO:0006084)2.92379968
115serine family amino acid metabolic process (GO:0009069)2.91353647
116very-low-density lipoprotein particle assembly (GO:0034379)2.91115585
117dorsal/ventral axis specification (GO:0009950)2.89707995
118coronary vasculature morphogenesis (GO:0060977)2.89679608
119benzene-containing compound metabolic process (GO:0042537)2.88606517
120heterochromatin organization (GO:0070828)2.88289803
121plasma lipoprotein particle assembly (GO:0034377)2.87831040
122heart valve formation (GO:0003188)2.87528184
123flavonoid metabolic process (GO:0009812)2.85366957
124cholesterol homeostasis (GO:0042632)2.84699881
125lipoprotein metabolic process (GO:0042157)2.82192319
126sterol homeostasis (GO:0055092)2.82030259
127lateral sprouting from an epithelium (GO:0060601)2.79878874
128mesodermal cell differentiation (GO:0048333)2.78999789
129establishment of apical/basal cell polarity (GO:0035089)2.78728614
130short-chain fatty acid metabolic process (GO:0046459)2.78563510
131regulation of bile acid biosynthetic process (GO:0070857)2.78345258
132regulation of neuroblast proliferation (GO:1902692)2.78103786
133organic acid catabolic process (GO:0016054)2.77725017
134carboxylic acid catabolic process (GO:0046395)2.77725017
135regulation of cardioblast differentiation (GO:0051890)2.77108668
136regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76668920
137muscle cell migration (GO:0014812)2.75828068
138heme transport (GO:0015886)2.75647765
139lens morphogenesis in camera-type eye (GO:0002089)2.75578164
140response to gravity (GO:0009629)2.75117317
141fatty acid oxidation (GO:0019395)2.74365006
142renal system development (GO:0072001)2.73869815
143negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.73038911
144neuron projection extension (GO:1990138)2.73032548
145positive regulation of Rho protein signal transduction (GO:0035025)2.72879688
146drug catabolic process (GO:0042737)2.72752521
147camera-type eye morphogenesis (GO:0048593)2.72637014
148fatty acid beta-oxidation (GO:0006635)2.72576079
149negative regulation of fatty acid biosynthetic process (GO:0045717)2.72134736
150establishment of tissue polarity (GO:0007164)2.72078087
151establishment of planar polarity (GO:0001736)2.72078087
152endothelial cell morphogenesis (GO:0001886)2.70925541
153neural crest cell development (GO:0014032)2.70323230
154atrial septum morphogenesis (GO:0060413)2.70088257
155regulation of axon guidance (GO:1902667)2.70065900
156positive regulation of pseudopodium assembly (GO:0031274)2.69751392
157lipid oxidation (GO:0034440)2.68735064
158carnitine metabolic process (GO:0009437)2.68088970
159protein localization to endosome (GO:0036010)2.68002970
160mesenchyme morphogenesis (GO:0072132)2.67983773
161negative regulation of cardiac muscle tissue development (GO:0055026)2.67645833
162phospholipid homeostasis (GO:0055091)2.67584481
163negative regulation of cell fate commitment (GO:0010454)2.67397476
164branching involved in salivary gland morphogenesis (GO:0060445)2.67126352
165regulation of cholesterol biosynthetic process (GO:0045540)2.65999741
166protein-lipid complex assembly (GO:0065005)2.65706727
167negative regulation of cartilage development (GO:0061037)2.64085137
168mesoderm formation (GO:0001707)2.62619153
169polarized epithelial cell differentiation (GO:0030859)2.62265970
170blood vessel endothelial cell migration (GO:0043534)2.60193358
171protein localization to microtubule (GO:0035372)2.59557570
172skin morphogenesis (GO:0043589)2.58592988
173heparan sulfate proteoglycan metabolic process (GO:0030201)2.57934392
174negative regulation of keratinocyte proliferation (GO:0010839)2.56200714
175endocardial cushion morphogenesis (GO:0003203)2.55122127
176heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.54099383
177bone trabecula formation (GO:0060346)2.53800760
178protein retention in ER lumen (GO:0006621)2.52728786
179mammary gland development (GO:0030879)2.52208590
180desmosome organization (GO:0002934)2.52129341
181apoptotic process involved in morphogenesis (GO:0060561)2.51301669
182protein heterotrimerization (GO:0070208)2.51071599
183regulation of pseudopodium assembly (GO:0031272)2.50932849
184hippo signaling (GO:0035329)2.49882902
185prostate gland epithelium morphogenesis (GO:0060740)2.49845395
186ephrin receptor signaling pathway (GO:0048013)2.49410032
187epithelial cell-cell adhesion (GO:0090136)2.49356729
188regulation of transforming growth factor beta2 production (GO:0032909)2.48733779
189activation of Rac GTPase activity (GO:0032863)2.48517283
190ventricular trabecula myocardium morphogenesis (GO:0003222)2.48430573
191focal adhesion assembly (GO:0048041)2.48115623
192cell-substrate adherens junction assembly (GO:0007045)2.48115623
193cell proliferation in forebrain (GO:0021846)2.47840130
194outer ear morphogenesis (GO:0042473)2.45462588
195vascular endothelial growth factor signaling pathway (GO:0038084)2.44891259
196developmental cell growth (GO:0048588)2.44058898
197establishment or maintenance of monopolar cell polarity (GO:0061339)2.43977174
198establishment of monopolar cell polarity (GO:0061162)2.43977174

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.32615691
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.49976868
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.62016156
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.47222444
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.95009398
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.77733313
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.44388286
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.33918992
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.20149482
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.00265989
11CLOCK_20551151_ChIP-Seq_293T_Human2.72284033
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.65023785
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.57680282
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.38864767
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.22738813
16* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.19655739
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.18472784
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.02978724
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.87500918
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82665320
21* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.72130722
22* EZH2_27304074_Chip-Seq_ESCs_Mouse1.70842382
23* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.68966839
24* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65323955
25* UBF1/2_26484160_Chip-Seq_HMECs_Human1.64289890
26* RNF2_27304074_Chip-Seq_ESCs_Mouse1.62236063
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52631408
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51036880
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48961652
30* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48212332
31TP53_22127205_ChIP-Seq_IMR90_Human1.47949592
32ZNF263_19887448_ChIP-Seq_K562_Human1.46514365
33* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46408119
34KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.45635089
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44491476
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.40827764
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.40827764
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.40827764
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.39423678
40* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39260098
41* CTCF_27219007_Chip-Seq_Bcells_Human1.38154070
42* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38024454
43TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.38012230
44SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36932017
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36420714
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33712487
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33682050
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32971760
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32971760
50* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31754774
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31686631
52* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30669592
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30309566
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29437932
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.28861365
56* EP300_21415370_ChIP-Seq_HL-1_Mouse1.28034628
57* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27539413
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26945865
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24107898
60CJUN_26792858_Chip-Seq_BT549_Human1.23115653
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23076047
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.22883203
63* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22581838
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21870083
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19293338
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18204379
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18094616
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.16827565
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15766857
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.15068278
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.14651615
72ATF3_27146783_Chip-Seq_COLON_Human1.14077524
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13896715
74* TP53_20018659_ChIP-ChIP_R1E_Mouse1.13867661
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12968020
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12404483
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11284579
78* KDM2B_26808549_Chip-Seq_JURKAT_Human1.11261442
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.10935586
80* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10248543
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10084222
82SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09768874
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08794644
84* ISL1_27105846_Chip-Seq_CPCs_Mouse1.08698969
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08117408
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.07684049
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07647162
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06634519
89* CBX2_27304074_Chip-Seq_ESCs_Mouse1.06475404
90* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05951824
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05402578
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05100596
93TBX20_22080862_ChIP-Seq_HEART_Mouse1.04772870
94TBX20_22328084_ChIP-Seq_HEART_Mouse1.04772870
95SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04275129
96* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04210483
97TET1_21490601_ChIP-Seq_MESCs_Mouse1.03438666
98TP53_23651856_ChIP-Seq_MEFs_Mouse1.03318280
99* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02919182
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02518988
101SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02232847
102KDM2B_26808549_Chip-Seq_DND41_Human1.02036003
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01785669
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01785669
105* ERG_21242973_ChIP-ChIP_JURKAT_Human1.00921420
106* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00654841
107SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00356498
108HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00187389
109RACK7_27058665_Chip-Seq_MCF-7_Human0.99617887
110* TET1_21451524_ChIP-Seq_MESCs_Mouse0.99361721
111* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98464360
112RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98152519
113SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96842057
114POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95964483
115ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95539099
116LXR_22292898_ChIP-Seq_THP-1_Human0.95288098
117GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95264783
118MYC_18555785_ChIP-Seq_MESCs_Mouse0.95175066
119P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93551655
120* KDM2B_26808549_Chip-Seq_K562_Human0.92672431
121SOX2_20726797_ChIP-Seq_SW620_Human0.92658970
122AR_21572438_ChIP-Seq_LNCaP_Human0.91916097
123ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90083469
124HNF4A_19822575_ChIP-Seq_HepG2_Human0.89222814
125* ELK3_25401928_ChIP-Seq_HUVEC_Human0.88569822
126CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88371838
127ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88333032
128* RING1B_27294783_Chip-Seq_NPCs_Mouse0.87305344
129* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86852188
130* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.85607910
131* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.85607910
132AHR_22903824_ChIP-Seq_MCF-7_Human0.85068482
133SMC1_22415368_ChIP-Seq_MEFs_Mouse0.84794557
134* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84377762
135PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83732575
136* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83325107
137* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81241312
138CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80943920
139STAT6_21828071_ChIP-Seq_BEAS2B_Human0.79086519
140SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.78948704
141PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.78590790
142* CREB1_26743006_Chip-Seq_LNCaP_Human0.78227221
143* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.77581218
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.75413819
145UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.75375155
146WT1_25993318_ChIP-Seq_PODOCYTE_Human0.74876844
147RUNX1_27514584_Chip-Seq_MCF-7_Human0.74351481
148GATA4_25053715_ChIP-Seq_YYC3_Human0.74186967
149BRD4_25478319_ChIP-Seq_HGPS_Human0.73226333
150* RING1B_27294783_Chip-Seq_ESCs_Mouse0.73100975
151* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.73025547

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.69059512
2MP0006292_abnormal_olfactory_placode5.13630693
3MP0005360_urolithiasis4.79306458
4MP0005085_abnormal_gallbladder_physiolo4.35171304
5MP0008438_abnormal_cutaneous_collagen4.24230966
6MP0005365_abnormal_bile_salt3.95535137
7MP0003705_abnormal_hypodermis_morpholog3.33229706
8MP0008875_abnormal_xenobiotic_pharmacok3.20015329
9MP0003252_abnormal_bile_duct2.98201953
10MP0003806_abnormal_nucleotide_metabolis2.54083748
11MP0005275_abnormal_skin_tensile2.50104544
12MP0008789_abnormal_olfactory_epithelium2.44479182
13MP0010030_abnormal_orbit_morphology2.43368469
14MP0002234_abnormal_pharynx_morphology2.30972677
15MP0010368_abnormal_lymphatic_system2.21562323
16MP0010329_abnormal_lipoprotein_level2.21043289
17MP0004272_abnormal_basement_membrane2.14455827
18MP0005499_abnormal_olfactory_system2.08650479
19MP0005394_taste/olfaction_phenotype2.08650479
20MP0009053_abnormal_anal_canal2.03100679
21MP0005503_abnormal_tendon_morphology1.99745386
22MP0009384_cardiac_valve_regurgitation1.94973501
23MP0005083_abnormal_biliary_tract1.93079954
24MP0009840_abnormal_foam_cell1.87860775
25MP0005332_abnormal_amino_acid1.81769291
26MP0001958_emphysema1.75715326
27MP0000751_myopathy1.75585203
28MP0003279_aneurysm1.68764586
29MP0002249_abnormal_larynx_morphology1.67016444
30MP0001293_anophthalmia1.66119365
31MP0002282_abnormal_trachea_morphology1.55354621
32MP0001666_abnormal_nutrient_absorption1.54325875
33MP0000778_abnormal_nervous_system1.53711167
34MP0002653_abnormal_ependyma_morphology1.47435834
35MP0005248_abnormal_Harderian_gland1.41928339
36MP0004858_abnormal_nervous_system1.40611524
37MP0002295_abnormal_pulmonary_circulatio1.39371772
38MP0003195_calcinosis1.39022744
39MP0002060_abnormal_skin_morphology1.37270364
40MP0003119_abnormal_digestive_system1.32447573
41MP0001286_abnormal_eye_development1.31998424
42MP0000566_synostosis1.31664323
43MP0001299_abnormal_eye_distance/1.30713421
44MP0009379_abnormal_foot_pigmentation1.30399580
45MP0000678_abnormal_parathyroid_gland1.28076629
46MP0002118_abnormal_lipid_homeostasis1.27397239
47MP0004019_abnormal_vitamin_homeostasis1.27038678
48MP0005508_abnormal_skeleton_morphology1.24758744
49MP0000609_abnormal_liver_physiology1.22046280
50MP0003566_abnormal_cell_adhesion1.21889459
51MP0003315_abnormal_perineum_morphology1.20969285
52MP0009250_abnormal_appendicular_skeleto1.20330654
53MP0000579_abnormal_nail_morphology1.16760434
54MP0005197_abnormal_uvea_morphology1.16707348
55MP0003385_abnormal_body_wall1.14827759
56MP0002098_abnormal_vibrissa_morphology1.14349435
57MP0005257_abnormal_intraocular_pressure1.12568347
58MP0002089_abnormal_postnatal_growth/wei1.08969420
59MP0000428_abnormal_craniofacial_morphol1.07343771
60MP0002896_abnormal_bone_mineralization1.06303730
61MP0002938_white_spotting1.05598343
62MP0001879_abnormal_lymphatic_vessel1.04392696
63MP0002254_reproductive_system_inflammat1.03710120
64MP0006054_spinal_hemorrhage1.03581922
65MP0003861_abnormal_nervous_system1.03458372
66MP0000733_abnormal_muscle_development1.02318903
67MP0005319_abnormal_enzyme/_coenzyme1.02072847
68MP0002085_abnormal_embryonic_tissue0.99892644
69MP0003868_abnormal_feces_composition0.98561869
70MP0005623_abnormal_meninges_morphology0.98201511
71MP0005023_abnormal_wound_healing0.97621685
72MP0003115_abnormal_respiratory_system0.96586026
73MP0002925_abnormal_cardiovascular_devel0.96547878
74MP0000163_abnormal_cartilage_morphology0.96215479
75MP0002168_other_aberrant_phenotype0.95643120
76MP0002084_abnormal_developmental_patter0.94209423
77MP0000613_abnormal_salivary_gland0.94088433
78MP0000767_abnormal_smooth_muscle0.92951436
79MP0000537_abnormal_urethra_morphology0.92519362
80MP0003942_abnormal_urinary_system0.91704714
81MP0009780_abnormal_chondrocyte_physiolo0.89256852
82MP0002932_abnormal_joint_morphology0.89057671
83MP0004133_heterotaxia0.88598374
84MP0002837_dystrophic_cardiac_calcinosis0.87819252
85MP0000049_abnormal_middle_ear0.87059127
86MP0002108_abnormal_muscle_morphology0.85465965
87MP0000762_abnormal_tongue_morphology0.84537031
88MP0003191_abnormal_cellular_cholesterol0.83672532
89MP0008932_abnormal_embryonic_tissue0.83496116
90MP0003755_abnormal_palate_morphology0.83436932
91MP0002233_abnormal_nose_morphology0.83113887
92MP0000462_abnormal_digestive_system0.82175525
93MP0003890_abnormal_embryonic-extraembry0.82060276
94MP0002092_abnormal_eye_morphology0.81191943
95MP0000383_abnormal_hair_follicle0.81106515
96MP0001340_abnormal_eyelid_morphology0.80990461
97MP0005501_abnormal_skin_physiology0.80013115
98MP0010678_abnormal_skin_adnexa0.79892822
99MP0005409_darkened_coat_color0.79746938
100MP0002114_abnormal_axial_skeleton0.79018719
101MP0003935_abnormal_craniofacial_develop0.78280902
102MP0002138_abnormal_hepatobiliary_system0.78068159
103MP0002115_abnormal_skeleton_extremities0.77690205
104MP0005408_hypopigmentation0.77566517
105MP0000598_abnormal_liver_morphology0.77408871
106MP0003011_delayed_dark_adaptation0.77265687
107MP0002109_abnormal_limb_morphology0.76930891
108MP0003941_abnormal_skin_development0.75741492
109MP0002128_abnormal_blood_circulation0.75508132
110MP0001346_abnormal_lacrimal_gland0.74257394
111MP0005193_abnormal_anterior_eye0.73994653
112MP0002177_abnormal_outer_ear0.72943834
113MP0006138_congestive_heart_failure0.72679325
114MP0001216_abnormal_epidermal_layer0.71972665
115MP0010630_abnormal_cardiac_muscle0.71562015
116MP0004233_abnormal_muscle_weight0.71287492
117MP0000749_muscle_degeneration0.70992401
118MP0002697_abnormal_eye_size0.70920070
119MP0005076_abnormal_cell_differentiation0.70237256
120MP0001614_abnormal_blood_vessel0.69837580
121MP0000467_abnormal_esophagus_morphology0.68794998
122MP0000534_abnormal_ureter_morphology0.68229022
123MP0004883_abnormal_blood_vessel0.68176218
124MP0001915_intracranial_hemorrhage0.67397702
125MP0004185_abnormal_adipocyte_glucose0.67386229
126MP0009643_abnormal_urine_homeostasis0.67380941
127MP0002796_impaired_skin_barrier0.67060865
128MP0002928_abnormal_bile_duct0.65743004
129MP0003937_abnormal_limbs/digits/tail_de0.65188777
130MP0005220_abnormal_exocrine_pancreas0.64766647
131MP0000432_abnormal_head_morphology0.63776249
132MP0005187_abnormal_penis_morphology0.62746793
133MP0003453_abnormal_keratinocyte_physiol0.61739084
134MP0001542_abnormal_bone_strength0.61566405
135MP0001849_ear_inflammation0.61366031
136MP0002116_abnormal_craniofacial_bone0.61138047
137MP0002111_abnormal_tail_morphology0.60320333
138MP0003283_abnormal_digestive_organ0.60074663
139MP0005666_abnormal_adipose_tissue0.58727756
140MP0005595_abnormal_vascular_smooth0.58269967
141MP0003091_abnormal_cell_migration0.57626277
142MP0005451_abnormal_body_composition0.57072518
143MP0004134_abnormal_chest_morphology0.56888224

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.91390899
2Intrahepatic cholestasis (HP:0001406)4.94099309
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.91371139
4Xanthomatosis (HP:0000991)4.67711574
5Premature rupture of membranes (HP:0001788)4.60427838
6Protrusio acetabuli (HP:0003179)4.53456583
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.46686318
8Prolonged partial thromboplastin time (HP:0003645)4.01440973
9Hypobetalipoproteinemia (HP:0003563)3.81516376
10Hyperlipoproteinemia (HP:0010980)3.64950398
11Shallow orbits (HP:0000586)3.58674329
12Hypoalphalipoproteinemia (HP:0003233)3.30669718
13Hypolipoproteinemia (HP:0010981)3.26590205
14Broad metatarsal (HP:0001783)3.22164941
15Coronal craniosynostosis (HP:0004440)3.20212762
16Complement deficiency (HP:0004431)3.06915193
17Ketosis (HP:0001946)3.02289800
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.00867960
19Fragile nails (HP:0001808)2.97704663
20Turricephaly (HP:0000262)2.94134626
21Abnormality of the common coagulation pathway (HP:0010990)2.93368875
22Peritonitis (HP:0002586)2.92036389
23Abnormality of the phalanges of the hallux (HP:0010057)2.90457122
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.90337708
25Hyperammonemia (HP:0001987)2.88390907
26Hyperglycinemia (HP:0002154)2.87324233
27Abnormality of the distal phalanx of the thumb (HP:0009617)2.80741877
2811 pairs of ribs (HP:0000878)2.78942806
29Abnormality of the intrinsic pathway (HP:0010989)2.78289403
30Joint hemorrhage (HP:0005261)2.74949499
31Abnormality of serine family amino acid metabolism (HP:0010894)2.71900988
32Abnormality of glycine metabolism (HP:0010895)2.71900988
33Hyperglycinuria (HP:0003108)2.71137698
34Epidermoid cyst (HP:0200040)2.71126754
35Short nail (HP:0001799)2.68287544
36Abnormality of the aortic arch (HP:0012303)2.63145639
37Hepatocellular carcinoma (HP:0001402)2.59189141
38Fat malabsorption (HP:0002630)2.58457745
39Hypochromic microcytic anemia (HP:0004840)2.54571682
40Pterygium (HP:0001059)2.53714024
41Hypoglycemic coma (HP:0001325)2.51177407
42Bladder diverticulum (HP:0000015)2.48886126
43Abnormality of sulfur amino acid metabolism (HP:0004339)2.48576387
44Mitral stenosis (HP:0001718)2.43445778
45Hypercholesterolemia (HP:0003124)2.42369521
46Wide anterior fontanel (HP:0000260)2.41989342
47Abnormal vertebral ossification (HP:0100569)2.40276255
48Broad thumb (HP:0011304)2.40216912
49Short 4th metacarpal (HP:0010044)2.39582047
50Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.39582047
51Mitral valve prolapse (HP:0001634)2.39047701
52Flat acetabular roof (HP:0003180)2.38994027
53Missing ribs (HP:0000921)2.38711161
54High anterior hairline (HP:0009890)2.38111529
55Abnormality of complement system (HP:0005339)2.38053192
56Natal tooth (HP:0000695)2.36271086
57Blue sclerae (HP:0000592)2.35843801
58Aortic dissection (HP:0002647)2.35296625
59Partial duplication of thumb phalanx (HP:0009944)2.34753643
60Cerebral aneurysm (HP:0004944)2.34259447
61Ulnar bowing (HP:0003031)2.34071752
62Abnormality of the distal phalanges of the toes (HP:0010182)2.33609374
63Atrophic scars (HP:0001075)2.33084287
64Spastic diplegia (HP:0001264)2.32796980
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.32779185
66Infantile muscular hypotonia (HP:0008947)2.29386999
67Abnormal cartilage morphology (HP:0002763)2.27946651
68Abnormality of methionine metabolism (HP:0010901)2.26487042
69Ankle contracture (HP:0006466)2.26144123
70Ketoacidosis (HP:0001993)2.25093283
71Myocardial infarction (HP:0001658)2.24579880
72Vertebral clefting (HP:0008428)2.23911889
73Neonatal short-limb short stature (HP:0008921)2.23806044
74Vertebral hypoplasia (HP:0008417)2.22978451
75Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.22978451
76Breast hypoplasia (HP:0003187)2.19661137
77Radial bowing (HP:0002986)2.18546878
78Milia (HP:0001056)2.17227946
79Partial duplication of the phalanx of hand (HP:0009999)2.16186448
80Back pain (HP:0003418)2.15480357
81Broad hallux (HP:0010055)2.15103890
82Genu recurvatum (HP:0002816)2.14425374
83Cardiovascular calcification (HP:0011915)2.13213777
84Broad phalanges of the hand (HP:0009768)2.10858388
85Arterial tortuosity (HP:0005116)2.10573325
86Hip contracture (HP:0003273)2.09667833
87Lymphangioma (HP:0100764)2.09181970
88Preaxial foot polydactyly (HP:0001841)2.08686646
89Flattened epiphyses (HP:0003071)2.07219993
90Septo-optic dysplasia (HP:0100842)2.06753841
91Alopecia of scalp (HP:0002293)2.06269336
92Broad finger (HP:0001500)2.05849180
93Skin nodule (HP:0200036)2.04504799
94Ectopia lentis (HP:0001083)2.03623288
95Maternal diabetes (HP:0009800)2.03213229
96Aortic aneurysm (HP:0004942)2.03133545
97Cupped ribs (HP:0000887)2.02016281
98Advanced eruption of teeth (HP:0006288)2.02001256
99Delayed CNS myelination (HP:0002188)2.01331789
100Abnormality of carpal bone ossification (HP:0006257)2.00899690
101Abnormal delivery (HP:0001787)2.00446953
102Broad phalanx (HP:0006009)2.00259379
103Mitral regurgitation (HP:0001653)1.98733063
104Vascular tortuosity (HP:0004948)1.98721884
105Abnormality of the proximal phalanges of the hand (HP:0009834)1.98206520
106Broad long bones (HP:0005622)1.98089295
107Bronchomalacia (HP:0002780)1.98013736
108Thin ribs (HP:0000883)1.96605751
109Selective tooth agenesis (HP:0001592)1.96574067
110Abnormality of the calcaneus (HP:0008364)1.96493738
111Fragile skin (HP:0001030)1.95610401
112Hepatoblastoma (HP:0002884)1.95493524
113Congenital glaucoma (HP:0001087)1.95253576
114Hyperacusis (HP:0010780)1.94688036
115Wormian bones (HP:0002645)1.94460248
116Esophageal varix (HP:0002040)1.93221688
117Increased connective tissue (HP:0009025)1.90606307
118Abnormality of the ischium (HP:0003174)1.89232918
119Hydroxyprolinuria (HP:0003080)1.88045415
120Abnormality of proline metabolism (HP:0010907)1.88045415
121Abnormality of the 4th metacarpal (HP:0010012)1.87893779
122Spinal rigidity (HP:0003306)1.87754666
123Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.87752316
124Camptodactyly of toe (HP:0001836)1.87703691
125Broad face (HP:0000283)1.86811698
126Steatorrhea (HP:0002570)1.86300593
127Abnormal ossification of hand bones (HP:0005921)1.86266568
128Biconcave vertebral bodies (HP:0004586)1.85858336
129Abnormality of fatty-acid metabolism (HP:0004359)1.85407757
130Soft skin (HP:0000977)1.84868509
131Right ventricular cardiomyopathy (HP:0011663)1.83870967
132Joint laxity (HP:0001388)1.82565894
133Mildly elevated creatine phosphokinase (HP:0008180)1.82389964
134Aneurysm (HP:0002617)1.82372287
135Follicular hyperkeratosis (HP:0007502)1.82330674
136Limited hip movement (HP:0008800)1.81863249
137Broad toe (HP:0001837)1.81790087
138Hypophosphatemic rickets (HP:0004912)1.81347380
139Abnormality of the Achilles tendon (HP:0005109)1.80966654
140Deviation of the hallux (HP:0010051)1.80171114
141Vascular calcification (HP:0004934)1.79885514
142Cervical subluxation (HP:0003308)1.79387118
143Obstructive sleep apnea (HP:0002870)1.79025281
144Bowing of the arm (HP:0006488)1.78070179
145Bowed forearm bones (HP:0003956)1.78070179
146Type 1 muscle fiber predominance (HP:0003803)1.76744563
147Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.76711644
148Short 1st metacarpal (HP:0010034)1.76711644
149Hallux valgus (HP:0001822)1.75204894
150Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74666883
151Laryngomalacia (HP:0001601)1.74186227
152Aplasia/Hypoplasia of the breasts (HP:0010311)1.73982450
153Disproportionate tall stature (HP:0001519)1.73259481
154Metaphyseal cupping (HP:0003021)1.72870272
155Hypoplastic ischia (HP:0003175)1.72362968
156Tibial bowing (HP:0002982)1.71639836
157Abnormality of dentin (HP:0010299)1.70614578
158Shawl scrotum (HP:0000049)1.70304311
159Hyperglycemia (HP:0003074)1.69802319
160Knee flexion contracture (HP:0006380)1.69296054
161Rib fusion (HP:0000902)1.68854177
162Hyperextensible skin (HP:0000974)1.67626200
163Vertebral arch anomaly (HP:0008438)1.66154874
164Renal dysplasia (HP:0000110)1.65896378
165Rickets (HP:0002748)1.63997718
166Vitreoretinal degeneration (HP:0000655)1.63969936
167Facial hemangioma (HP:0000329)1.63940154
168Aplasia/Hypoplasia of the clavicles (HP:0006710)1.63506496
169Onycholysis (HP:0001806)1.63360952
170Abnormal tarsal ossification (HP:0008369)1.62780844
171Achilles tendon contracture (HP:0001771)1.62427302
172Tracheal stenosis (HP:0002777)1.61940408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK14.05455092
2EPHB23.73488947
3DDR23.57809271
4LATS13.36085448
5TRIB33.11854307
6PDGFRA2.69029252
7BCKDK2.67453518
8PKN22.59566594
9ERN12.36204382
10FGFR42.04088573
11MAPK152.02860409
12RIPK11.94498951
13MET1.86217495
14PTK61.81227862
15TTN1.80358143
16FGFR21.76840344
17EPHA41.72412993
18MAP3K101.70372834
19LATS21.69207603
20ICK1.67443063
21NME21.64593729
22EPHA31.62905144
23IRAK31.62501791
24EEF2K1.59343489
25EPHB11.50875179
26MAP3K31.49842877
27ERBB41.47728494
28BMX1.47212208
29TIE11.46911226
30SMG11.46061214
31FER1.38674017
32PAK21.35670586
33PTK21.34189206
34ARAF1.32376686
35MAP3K21.29235996
36CDK61.26317158
37TGFBR21.25487812
38MST1R1.19144882
39GSK3A1.17155221
40TYRO31.10919619
41FRK1.09919351
42INSRR1.09743289
43ERBB21.08259220
44MAP2K21.07801384
45MTOR1.04885041
46NTRK11.02277987
47PAK41.00639512
48DYRK1B1.00233624
49PAK30.98726533
50LRRK20.93934846
51RPS6KA20.91178155
52FLT30.89934621
53PNCK0.89484878
54STK30.88860740
55PDGFRB0.88777117
56CDC70.84920674
57PIK3CA0.83947814
58FGFR10.80654537
59NEK90.80222927
60MARK20.79185835
61TGFBR10.76182929
62DYRK30.76142392
63LMTK20.73548312
64STK38L0.73544716
65MAP3K90.72666400
66MAP3K60.71797730
67PIM20.71666427
68IRAK20.71571671
69CDK80.70829257
70KDR0.68992842
71ABL20.67417692
72PRKD10.67151828
73BRAF0.66252798
74PRKD20.64693096
75ROCK10.64197215
76DMPK0.63044852
77NUAK10.62451343
78MAP2K10.61657223
79RET0.60644989
80FGFR30.58115480
81RPS6KA60.57514818
82CAMK1D0.56879666
83MYLK0.56256982
84TRPM70.55460875
85PRKCH0.53685729
86MAP2K30.53391946
87WNK10.53039817
88HIPK20.53011090
89PHKG10.52835007
90PHKG20.52835007
91MAPK70.50977073
92MAP3K70.50781234
93BRSK20.49704666
94AURKA0.49565118
95PRKAA20.48782686
96MAPK110.48575554
97STK380.47330247
98CSNK1G10.45086487
99MAP3K110.44017486
100CDK30.43752430
101BRSK10.42373713
102MELK0.42345689
103IRAK10.41911249
104PAK60.39946945
105AURKB0.39450246
106WEE10.39200747
107PRKCZ0.38703317
108INSR0.37955566
109MAPK40.37954043
110WNK40.37824406
111IGF1R0.37339009
112MAP2K40.37291015
113CSNK1A1L0.37089029
114ILK0.36799160
115PINK10.36318075
116RPS6KA10.36119442
117MOS0.35726171
118JAK20.35092086
119PRKCI0.34993860
120STK390.34629567
121LIMK10.34522204
122ADRBK10.34382106
123ROCK20.34116158
124AKT20.34043165
125NEK20.33301848
126CAMK1G0.32509024
127EPHA20.32151539
128PIK3CG0.31955183
129TAOK10.31832217
130PTK2B0.31792871
131RPS6KL10.30943812
132RPS6KC10.30943812
133PRKD30.30722143
134PRKAA10.30051702
135MAP2K70.29438904
136TESK10.29062031
137MAP3K80.27659757
138TTK0.27142220
139CDC42BPA0.24850138
140AKT30.24432653
141CHEK20.23077627
142AKT10.20211890
143CAMK2G0.19260693

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.94097084
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.47688604
3Nitrogen metabolism_Homo sapiens_hsa009103.09484082
4Arginine biosynthesis_Homo sapiens_hsa002202.71572963
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.66085647
6Complement and coagulation cascades_Homo sapiens_hsa046102.63180941
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62666279
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.59465196
9Tryptophan metabolism_Homo sapiens_hsa003802.48478946
10Fatty acid degradation_Homo sapiens_hsa000712.42374685
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.35519050
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33200938
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30536839
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20428674
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15654325
16Butanoate metabolism_Homo sapiens_hsa006502.09393826
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.04692415
18Chemical carcinogenesis_Homo sapiens_hsa052042.03239973
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.01031056
20Small cell lung cancer_Homo sapiens_hsa052221.93709867
21PPAR signaling pathway_Homo sapiens_hsa033201.92320076
22Fatty acid metabolism_Homo sapiens_hsa012121.89433252
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.88391894
24* Wnt signaling pathway_Homo sapiens_hsa043101.84186319
25Propanoate metabolism_Homo sapiens_hsa006401.79011514
26Peroxisome_Homo sapiens_hsa041461.67547470
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62398522
28Histidine metabolism_Homo sapiens_hsa003401.61803392
29Sulfur metabolism_Homo sapiens_hsa009201.56680445
30Bile secretion_Homo sapiens_hsa049761.56360324
31Retinol metabolism_Homo sapiens_hsa008301.53628246
32Phenylalanine metabolism_Homo sapiens_hsa003601.50698148
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.44819308
34beta-Alanine metabolism_Homo sapiens_hsa004101.44653207
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.42140615
36Ribosome_Homo sapiens_hsa030101.41385331
37Starch and sucrose metabolism_Homo sapiens_hsa005001.38674705
38Tyrosine metabolism_Homo sapiens_hsa003501.36100279
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.33514466
40Fatty acid elongation_Homo sapiens_hsa000621.31876496
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30230542
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29402232
43* Melanogenesis_Homo sapiens_hsa049161.28198014
44Caffeine metabolism_Homo sapiens_hsa002321.27874424
45Selenocompound metabolism_Homo sapiens_hsa004501.27749041
46* Pathways in cancer_Homo sapiens_hsa052001.25311961
47Steroid biosynthesis_Homo sapiens_hsa001001.24608216
48Staphylococcus aureus infection_Homo sapiens_hsa051501.21131716
49Lysine degradation_Homo sapiens_hsa003101.20912704
50Thyroid cancer_Homo sapiens_hsa052161.19556771
51Melanoma_Homo sapiens_hsa052181.17403783
52Arginine and proline metabolism_Homo sapiens_hsa003301.15508535
53ErbB signaling pathway_Homo sapiens_hsa040121.14612097
54Chronic myeloid leukemia_Homo sapiens_hsa052201.13543360
55Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12916409
56Pyruvate metabolism_Homo sapiens_hsa006201.10170907
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.09896467
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07196589
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06920236
60ECM-receptor interaction_Homo sapiens_hsa045121.03959633
61Cyanoamino acid metabolism_Homo sapiens_hsa004601.02341883
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01511307
63Fat digestion and absorption_Homo sapiens_hsa049751.00893921
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00296246
65Endometrial cancer_Homo sapiens_hsa052131.00252558
66Glioma_Homo sapiens_hsa052141.00033607
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00001488
68Prostate cancer_Homo sapiens_hsa052150.97645036
69Biosynthesis of amino acids_Homo sapiens_hsa012300.93081397
70ABC transporters_Homo sapiens_hsa020100.92395292
71Colorectal cancer_Homo sapiens_hsa052100.92388756
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90611812
73Renal cell carcinoma_Homo sapiens_hsa052110.85227225
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82813349
75Rap1 signaling pathway_Homo sapiens_hsa040150.82088577
76Carbon metabolism_Homo sapiens_hsa012000.81908997
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80805695
78Folate biosynthesis_Homo sapiens_hsa007900.79428388
79Fatty acid biosynthesis_Homo sapiens_hsa000610.77262620
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77167837
81VEGF signaling pathway_Homo sapiens_hsa043700.75997886
82* Basal cell carcinoma_Homo sapiens_hsa052170.72493925
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.71861068
84Sulfur relay system_Homo sapiens_hsa041220.70257861
85Glutathione metabolism_Homo sapiens_hsa004800.68223919
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67911588
87Pancreatic cancer_Homo sapiens_hsa052120.67506168
88Cell cycle_Homo sapiens_hsa041100.66984504
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65277639
90Focal adhesion_Homo sapiens_hsa045100.64755634
91N-Glycan biosynthesis_Homo sapiens_hsa005100.64416568
92Gap junction_Homo sapiens_hsa045400.64111043
93mRNA surveillance pathway_Homo sapiens_hsa030150.63785169
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61599019
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60496351
96Vitamin digestion and absorption_Homo sapiens_hsa049770.59503612
97Protein digestion and absorption_Homo sapiens_hsa049740.59220021
98* Hippo signaling pathway_Homo sapiens_hsa043900.55524849
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.54927107
100Insulin resistance_Homo sapiens_hsa049310.54520292
101mTOR signaling pathway_Homo sapiens_hsa041500.54435773
102Bladder cancer_Homo sapiens_hsa052190.54175914
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54081516
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53358918
105TGF-beta signaling pathway_Homo sapiens_hsa043500.53139836
106Inositol phosphate metabolism_Homo sapiens_hsa005620.52014168
107Non-small cell lung cancer_Homo sapiens_hsa052230.51915311
108Alcoholism_Homo sapiens_hsa050340.51409871
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.50997736
110Adherens junction_Homo sapiens_hsa045200.50944208
111Nucleotide excision repair_Homo sapiens_hsa034200.50612016
112p53 signaling pathway_Homo sapiens_hsa041150.49631578
113Galactose metabolism_Homo sapiens_hsa000520.49192057
114Hedgehog signaling pathway_Homo sapiens_hsa043400.48923326
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48348692
116* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48150297
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.47300229
118* HTLV-I infection_Homo sapiens_hsa051660.45534533
119GnRH signaling pathway_Homo sapiens_hsa049120.44686844
120Prion diseases_Homo sapiens_hsa050200.44189918
121* Proteoglycans in cancer_Homo sapiens_hsa052050.43827405
122DNA replication_Homo sapiens_hsa030300.42877234
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42603722
124Amoebiasis_Homo sapiens_hsa051460.42407742
125Estrogen signaling pathway_Homo sapiens_hsa049150.42012245
126One carbon pool by folate_Homo sapiens_hsa006700.41914306
127Cardiac muscle contraction_Homo sapiens_hsa042600.41558166
128Notch signaling pathway_Homo sapiens_hsa043300.41145000
129Glycerolipid metabolism_Homo sapiens_hsa005610.39943459
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.39548896
131cAMP signaling pathway_Homo sapiens_hsa040240.39129587
132Vitamin B6 metabolism_Homo sapiens_hsa007500.38902567
133Thyroid hormone synthesis_Homo sapiens_hsa049180.38478959
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38167996
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37766170
136FoxO signaling pathway_Homo sapiens_hsa040680.37032438
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33849995
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32919621
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.32635917
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32444708
141Pyrimidine metabolism_Homo sapiens_hsa002400.31919060
142Circadian rhythm_Homo sapiens_hsa047100.30048583
143Ras signaling pathway_Homo sapiens_hsa040140.28877290
144Choline metabolism in cancer_Homo sapiens_hsa052310.28661729
145HIF-1 signaling pathway_Homo sapiens_hsa040660.28508272
146AMPK signaling pathway_Homo sapiens_hsa041520.28253038
147Tight junction_Homo sapiens_hsa045300.25403637
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25037780
149Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23419671
150Ovarian steroidogenesis_Homo sapiens_hsa049130.22234736
151Metabolic pathways_Homo sapiens_hsa011000.21885217
152Glucagon signaling pathway_Homo sapiens_hsa049220.21629695
153Axon guidance_Homo sapiens_hsa043600.18493509
154MicroRNAs in cancer_Homo sapiens_hsa052060.18139131
155Dilated cardiomyopathy_Homo sapiens_hsa054140.16870367
156Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16063834
157alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15896186
158Central carbon metabolism in cancer_Homo sapiens_hsa052300.15533357
159Insulin signaling pathway_Homo sapiens_hsa049100.15522945
160Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.13914209
161AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.13438365
162Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13214041
163Dorso-ventral axis formation_Homo sapiens_hsa043200.12815721

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