FZD9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of somitogenesis (GO:0014807)6.65236637
2actin-myosin filament sliding (GO:0033275)5.04667281
3muscle filament sliding (GO:0030049)5.04667281
4auditory receptor cell differentiation (GO:0042491)4.94968354
5pentose metabolic process (GO:0019321)4.92061471
6muscle cell fate commitment (GO:0042693)4.90079490
7regulation of skeletal muscle cell differentiation (GO:2001014)4.63852373
8regulation of mammary gland epithelial cell proliferation (GO:0033599)4.26824129
9Notch signaling involved in heart development (GO:0061314)4.17010892
10plasma membrane repair (GO:0001778)4.13260534
11lens fiber cell development (GO:0070307)4.11817247
12endocardial cushion morphogenesis (GO:0003203)4.07768867
13protein polyglutamylation (GO:0018095)4.05509523
14skeletal muscle contraction (GO:0003009)4.03700325
15ribosomal small subunit biogenesis (GO:0042274)3.93973468
16skeletal muscle fiber development (GO:0048741)3.85866695
17actin-mediated cell contraction (GO:0070252)3.82757101
18negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.81263828
19lateral sprouting from an epithelium (GO:0060601)3.80415072
20mammary gland epithelial cell differentiation (GO:0060644)3.76898100
21tooth mineralization (GO:0034505)3.71323265
22creatine metabolic process (GO:0006600)3.67256034
23planar cell polarity pathway involved in neural tube closure (GO:0090179)3.65140566
24positive regulation of Notch signaling pathway (GO:0045747)3.63345758
25lymph vessel development (GO:0001945)3.59477888
26paraxial mesoderm development (GO:0048339)3.52698840
27neuronal stem cell maintenance (GO:0097150)3.52672852
28regulation of skeletal muscle contraction (GO:0014819)3.45453187
29regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.44071508
30cranial nerve morphogenesis (GO:0021602)3.43791597
31heterochromatin organization (GO:0070828)3.42930170
32mitotic chromosome condensation (GO:0007076)3.38557992
33ventricular septum morphogenesis (GO:0060412)3.35787345
34locomotory exploration behavior (GO:0035641)3.35442375
35hair cell differentiation (GO:0035315)3.34012288
36protein complex localization (GO:0031503)3.33895743
37regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.31905021
38type B pancreatic cell proliferation (GO:0044342)3.30990396
39outer ear morphogenesis (GO:0042473)3.30951128
40positive regulation of myotube differentiation (GO:0010831)3.27485947
41regulation of hippo signaling (GO:0035330)3.27385044
42aorta morphogenesis (GO:0035909)3.27093185
43L-serine metabolic process (GO:0006563)3.26323724
44proline biosynthetic process (GO:0006561)3.25884047
45heart trabecula morphogenesis (GO:0061384)3.22028576
46fat-soluble vitamin catabolic process (GO:0042363)3.21785939
47vitamin catabolic process (GO:0009111)3.21785939
48galactose catabolic process (GO:0019388)3.21536823
49heart valve formation (GO:0003188)3.21467183
50inner ear receptor cell differentiation (GO:0060113)3.21354825
51actin filament-based movement (GO:0030048)3.19801795
52protein maturation by protein folding (GO:0022417)3.18647854
53cardiac myofibril assembly (GO:0055003)3.16920833
54mesenchyme morphogenesis (GO:0072132)3.14386005
55negative regulation of smoothened signaling pathway (GO:0045879)3.11440918
56cellular sodium ion homeostasis (GO:0006883)3.07854881
57polarized epithelial cell differentiation (GO:0030859)3.06019119
58regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.05987814
59myotube cell development (GO:0014904)3.04842947
60skeletal muscle adaptation (GO:0043501)3.04369738
61positive regulation of skeletal muscle tissue development (GO:0048643)3.03771554
62heart valve morphogenesis (GO:0003179)3.03341967
63negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.99800993
64sarcoplasmic reticulum calcium ion transport (GO:0070296)2.98421596
65epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.98381774
66layer formation in cerebral cortex (GO:0021819)2.95361961
67muscle organ morphogenesis (GO:0048644)2.94084077
68regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.93245090
69notochord development (GO:0030903)2.92862504
70mechanoreceptor differentiation (GO:0042490)2.92402514
71glial cell proliferation (GO:0014009)2.90186100
72sarcomere organization (GO:0045214)2.88257206
73cellular protein complex localization (GO:0034629)2.86673609
74apoptotic process involved in morphogenesis (GO:0060561)2.85209943
75establishment of tissue polarity (GO:0007164)2.82976609
76establishment of planar polarity (GO:0001736)2.82976609
77glycoprotein catabolic process (GO:0006516)2.82837483
78nucleotide salvage (GO:0043173)2.82633088
79regulation of NFAT protein import into nucleus (GO:0051532)2.82344727
80negative regulation of potassium ion transmembrane transport (GO:1901380)2.82079670
81anatomical structure regression (GO:0060033)2.81936975
82DNA unwinding involved in DNA replication (GO:0006268)2.80999142
83viral transcription (GO:0019083)2.80040313
84regulation of heart morphogenesis (GO:2000826)2.79595938
85outflow tract septum morphogenesis (GO:0003148)2.79182900
86cochlea morphogenesis (GO:0090103)2.78233540
87pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.78217346
88pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.77949087
89regulation of secondary heart field cardioblast proliferation (GO:0003266)2.77266146
90regulation of cardioblast proliferation (GO:0003264)2.77266146
91lung-associated mesenchyme development (GO:0060484)2.76931204
92non-canonical Wnt signaling pathway (GO:0035567)2.76926687
93neural tube development (GO:0021915)2.76160821
94gluconeogenesis (GO:0006094)2.76059609
95protein retention in ER lumen (GO:0006621)2.74806664
96trabecula morphogenesis (GO:0061383)2.74310564
97cartilage condensation (GO:0001502)2.74036781
98cell aggregation (GO:0098743)2.74036781
99skeletal muscle organ development (GO:0060538)2.72602833
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.72240918
101adherens junction assembly (GO:0034333)2.71851694
102mitotic G1 DNA damage checkpoint (GO:0031571)2.71288328
103intracellular estrogen receptor signaling pathway (GO:0030520)2.70621470
104peptidyl-lysine dimethylation (GO:0018027)2.70598217
105epithelial cell differentiation involved in prostate gland development (GO:0060742)2.69744929
106IMP metabolic process (GO:0046040)2.69039240
107somatic stem cell division (GO:0048103)2.68446892
108IMP biosynthetic process (GO:0006188)2.67800382
109neuromuscular junction development (GO:0007528)2.66525121
110hippo signaling (GO:0035329)2.66338768
111DNA replication initiation (GO:0006270)2.66044964
112NADH metabolic process (GO:0006734)2.65348446
113myofibril assembly (GO:0030239)2.65296157
114cardiac cell development (GO:0055006)2.65014866
115peptidyl-arginine omega-N-methylation (GO:0035247)2.64473840
116embryonic viscerocranium morphogenesis (GO:0048703)2.63590276
117basement membrane organization (GO:0071711)2.63226837
118negative regulation of cell size (GO:0045792)2.61604341
119positive regulation of myoblast differentiation (GO:0045663)2.60745441
120cardiac ventricle morphogenesis (GO:0003208)2.60680770
121collecting duct development (GO:0072044)2.60345206
122pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.59828888
123ectodermal placode formation (GO:0060788)2.59321079
124pyrimidine-containing compound salvage (GO:0008655)2.59074588
125pyrimidine nucleoside salvage (GO:0043097)2.59074588
126striated muscle contraction (GO:0006941)2.59064452
127pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.58263090
128labyrinthine layer blood vessel development (GO:0060716)2.57629192
129protein hydroxylation (GO:0018126)2.57074235
130cardiac right ventricle morphogenesis (GO:0003215)2.56927839
131positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.55461457
132lipopolysaccharide biosynthetic process (GO:0009103)2.54653990
133CTP metabolic process (GO:0046036)2.54342687
134CTP biosynthetic process (GO:0006241)2.54342687
135diaphragm development (GO:0060539)2.53687690
136translational termination (GO:0006415)2.53576822
137positive regulation of synapse maturation (GO:0090129)2.52967364
138skeletal muscle tissue regeneration (GO:0043403)2.51907660
139convergent extension (GO:0060026)2.51813071
1404-hydroxyproline metabolic process (GO:0019471)2.51011119
141muscle cell cellular homeostasis (GO:0046716)2.50798819
142pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.49562083
143glycogen biosynthetic process (GO:0005978)2.49073754
144glucan biosynthetic process (GO:0009250)2.49073754
145heart trabecula formation (GO:0060347)2.49029080
146hexose biosynthetic process (GO:0019319)2.48928226
147pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.46997237
148neuromuscular synaptic transmission (GO:0007274)2.46350515
149maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.45784417
150histone arginine methylation (GO:0034969)2.45431815
151peptidyl-arginine N-methylation (GO:0035246)2.43823803
152peptidyl-arginine methylation (GO:0018216)2.43823803
153Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.43656782
154mitochondrial fusion (GO:0008053)2.43577878
155glycogen catabolic process (GO:0005980)2.43186104
156thyroid gland development (GO:0030878)2.43039697
157negative regulation of astrocyte differentiation (GO:0048712)2.41645739
158respiratory system process (GO:0003016)2.38893375
159middle ear morphogenesis (GO:0042474)2.38020296
160regulation of early endosome to late endosome transport (GO:2000641)2.38020043
161translational elongation (GO:0006414)2.37904856
162nucleobase-containing small molecule interconversion (GO:0015949)2.36606400
163striated muscle cell proliferation (GO:0014855)2.34010956
164pharyngeal system development (GO:0060037)2.33655218
165cardiac muscle cell proliferation (GO:0060038)2.33167176
166G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.31076912
167response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.30414044
168DNA strand elongation involved in DNA replication (GO:0006271)2.30082219
169regulation of cardioblast differentiation (GO:0051890)2.29740403
170monosaccharide biosynthetic process (GO:0046364)2.28836948
171dorsal/ventral neural tube patterning (GO:0021904)2.28516880
172cardiac septum morphogenesis (GO:0060411)2.28144647
173DNA strand elongation (GO:0022616)2.28100677
174maturation of SSU-rRNA (GO:0030490)2.26666998
175UMP metabolic process (GO:0046049)2.26162490
176UMP biosynthetic process (GO:0006222)2.26162490

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.75044411
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.54831648
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.47175604
4ZNF263_19887448_ChIP-Seq_K562_Human3.24011419
5ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.69523448
6ERG_21242973_ChIP-ChIP_JURKAT_Human2.60692169
7ZFP281_18757296_ChIP-ChIP_E14_Mouse2.56092595
8E2F7_22180533_ChIP-Seq_HELA_Human2.29135404
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23676148
10SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.22515619
11WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.16517994
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14275966
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.08487122
14KDM2B_26808549_Chip-Seq_DND41_Human2.07618511
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06831843
16* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.02699111
17XRN2_22483619_ChIP-Seq_HELA_Human1.99127849
18SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.97819866
19SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.97398002
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95175760
21MYC_22102868_ChIP-Seq_BL_Human1.95018005
22TET1_21451524_ChIP-Seq_MESCs_Mouse1.94721715
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.94376785
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.94168219
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.94168219
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.94168219
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93691230
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.83774840
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.83339162
30TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.83273337
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82646913
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.81498971
33SRY_22984422_ChIP-ChIP_TESTIS_Rat1.78723214
34* KDM2B_26808549_Chip-Seq_K562_Human1.78010056
35* LXR_22292898_ChIP-Seq_THP-1_Human1.75418214
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72417141
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.70749570
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.68737189
39P68_20966046_ChIP-Seq_HELA_Human1.66651494
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66597633
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65842885
42NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.64542991
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63789977
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63541022
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.63377664
46* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61551403
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60844656
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.60632680
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.54965136
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54660007
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53971796
52KDM2B_26808549_Chip-Seq_JURKAT_Human1.53876849
53RACK7_27058665_Chip-Seq_MCF-7_Human1.53572973
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51413670
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.48851528
56POU5F1_16518401_ChIP-PET_MESCs_Mouse1.48817050
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.47134966
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47038738
59TCF7_22412390_ChIP-Seq_EML_Mouse1.45250100
60DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.45190701
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.44765175
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44481807
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43142252
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.43005513
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41975385
66SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.41559933
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40268452
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38928556
69CREB1_26743006_Chip-Seq_LNCaP_Human1.38803315
70* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38631537
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38561988
72NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.38468082
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38276085
74EZH2_22144423_ChIP-Seq_EOC_Human1.34897606
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.33447732
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.33370255
77JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32096327
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.31453431
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.30681456
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.30302341
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30050814
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29962576
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27827891
84VDR_21846776_ChIP-Seq_THP-1_Human1.27698837
85CLOCK_20551151_ChIP-Seq_293T_Human1.27441979
86* RNF2_27304074_Chip-Seq_ESCs_Mouse1.27403431
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27271068
88SMC4_20622854_ChIP-Seq_HELA_Human1.27096564
89SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.25820743
90CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24626766
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24217164
92NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21455700
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21166138
94NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20576627
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20560778
96EGR1_19374776_ChIP-ChIP_THP-1_Human1.19938306
97FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19703848
98RUNX1_27514584_Chip-Seq_MCF-7_Human1.18976567
99CTCF_26484167_Chip-Seq_Bcells_Mouse1.18773952
100ELF1_20517297_ChIP-Seq_JURKAT_Human1.16786982
101* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16371483
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16178541
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16032267
104RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15949089
105EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15949089
106RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15944967
107TCF3_18692474_ChIP-Seq_MESCs_Mouse1.15321751
108FOXP1_21924763_ChIP-Seq_HESCs_Human1.15296368
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15286077
110TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.14925800
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13152825
112CTCF_27219007_Chip-Seq_Bcells_Human1.12310632
113STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.12242254
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12213713
115YY1_21170310_ChIP-Seq_MESCs_Mouse1.11263370
116* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10573372
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10309761
118OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10216431
119* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09123066
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09038725
121CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08911512
122NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08863712
123ATF3_27146783_Chip-Seq_COLON_Human1.07864709
124E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07778972
125PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.06683626
126SA1_27219007_Chip-Seq_Bcells_Human1.06023943
127CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05827403
128RARA_24833708_ChIP-Seq_LIVER_Mouse1.05374027
129TTF2_22483619_ChIP-Seq_HELA_Human1.05221014
130SA1_27219007_Chip-Seq_ERYTHROID_Human1.03365114
131DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03033044
132SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02241660
133NANOG_21062744_ChIP-ChIP_HESCs_Human1.01938422
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01661240
135TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01509609
136EED_16625203_ChIP-ChIP_MESCs_Mouse1.01108499
137KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00844562
138ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00678483
139* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00222896
140KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97933485
141ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97819330
142* EZH2_27294783_Chip-Seq_ESCs_Mouse0.97789723
143TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97457059
144EZH2_27304074_Chip-Seq_ESCs_Mouse0.96981345
145TP53_22127205_ChIP-Seq_IMR90_Human0.96105466
146CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96053667
147KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94479458

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot4.44319893
2MP0003878_abnormal_ear_physiology4.44319893
3MP0004145_abnormal_muscle_electrophysio3.65543051
4MP0003879_abnormal_hair_cell3.45545069
5MP0001485_abnormal_pinna_reflex3.34764092
6MP0002653_abnormal_ependyma_morphology3.18929958
7MP0000751_myopathy3.12965427
8MP0003646_muscle_fatigue2.49930293
9MP0000747_muscle_weakness2.41368871
10MP0005451_abnormal_body_composition2.25274316
11MP0001346_abnormal_lacrimal_gland2.24164176
12MP0000749_muscle_degeneration2.13531712
13MP0009780_abnormal_chondrocyte_physiolo2.13258289
14MP0004233_abnormal_muscle_weight2.12138648
15MP0002106_abnormal_muscle_physiology2.11789142
16MP0000678_abnormal_parathyroid_gland2.06169166
17MP0003705_abnormal_hypodermis_morpholog2.05876243
18MP0000026_abnormal_inner_ear2.00181409
19MP0002249_abnormal_larynx_morphology1.98053673
20MP0000733_abnormal_muscle_development1.92933563
21MP0001963_abnormal_hearing_physiology1.90084517
22MP0000750_abnormal_muscle_regeneration1.87081732
23MP0004185_abnormal_adipocyte_glucose1.85161520
24MP0004134_abnormal_chest_morphology1.85116908
25MP0004087_abnormal_muscle_fiber1.81108120
26MP0005369_muscle_phenotype1.78819352
27MP0000759_abnormal_skeletal_muscle1.78158158
28MP0000049_abnormal_middle_ear1.78144941
29MP0001849_ear_inflammation1.76011627
30MP0008438_abnormal_cutaneous_collagen1.73725595
31MP0003693_abnormal_embryo_hatching1.72156192
32MP0002089_abnormal_postnatal_growth/wei1.70694665
33MP0000428_abnormal_craniofacial_morphol1.70613159
34MP0002932_abnormal_joint_morphology1.70239306
35MP0005058_abnormal_lysosome_morphology1.67463811
36MP0004885_abnormal_endolymph1.65656772
37MP0004858_abnormal_nervous_system1.65415182
38MP0002269_muscular_atrophy1.61304284
39MP0010030_abnormal_orbit_morphology1.59217126
40MP0004036_abnormal_muscle_relaxation1.55422476
41MP0008932_abnormal_embryonic_tissue1.47919976
42MP0003111_abnormal_nucleus_morphology1.47616233
43MP0004084_abnormal_cardiac_muscle1.46785730
44MP0003283_abnormal_digestive_organ1.45782302
45MP0002877_abnormal_melanocyte_morpholog1.43304711
46MP0004859_abnormal_synaptic_plasticity1.42076212
47MP0000566_synostosis1.39336214
48MP0009379_abnormal_foot_pigmentation1.39018725
49MP0002234_abnormal_pharynx_morphology1.38557935
50MP0005508_abnormal_skeleton_morphology1.36990995
51MP0005623_abnormal_meninges_morphology1.35185032
52MP0009672_abnormal_birth_weight1.33918198
53MP0002697_abnormal_eye_size1.31796070
54MP0000762_abnormal_tongue_morphology1.29906103
55MP0004130_abnormal_muscle_cell1.29041797
56MP0003567_abnormal_fetal_cardiomyocyte1.26887033
57MP0004197_abnormal_fetal_growth/weight/1.26772773
58MP0003942_abnormal_urinary_system1.25851784
59MP0003115_abnormal_respiratory_system1.25739057
60MP0003123_paternal_imprinting1.24981458
61MP0000534_abnormal_ureter_morphology1.24584642
62MP0000778_abnormal_nervous_system1.23788236
63MP0005670_abnormal_white_adipose1.23615005
64MP0001299_abnormal_eye_distance/1.21566339
65MP0002108_abnormal_muscle_morphology1.21263809
66MP0009278_abnormal_bone_marrow1.20201255
67MP0009250_abnormal_appendicular_skeleto1.18718547
68MP0004272_abnormal_basement_membrane1.17294721
69MP0002084_abnormal_developmental_patter1.15385975
70MP0005666_abnormal_adipose_tissue1.15267667
71MP0008260_abnormal_autophagy1.14662288
72MP0008770_decreased_survivor_rate1.13768764
73MP0010234_abnormal_vibrissa_follicle1.11715281
74MP0003077_abnormal_cell_cycle1.10200263
75MP0005620_abnormal_muscle_contractility1.08101220
76MP0003119_abnormal_digestive_system1.07822370
77MP0002116_abnormal_craniofacial_bone1.05853809
78MP0002092_abnormal_eye_morphology1.05781439
79MP0010630_abnormal_cardiac_muscle1.05764980
80MP0005257_abnormal_intraocular_pressure1.05524379
81MP0002085_abnormal_embryonic_tissue1.05450793
82MP0005076_abnormal_cell_differentiation1.05344146
83MP0003755_abnormal_palate_morphology1.03587060
84MP0000003_abnormal_adipose_tissue1.01011003
85MP0002822_catalepsy1.00940539
86MP0004957_abnormal_blastocyst_morpholog0.99598563
87MP0005375_adipose_tissue_phenotype0.99501364
88MP0010368_abnormal_lymphatic_system0.98492458
89MP0002282_abnormal_trachea_morphology0.97988682
90MP0001293_anophthalmia0.97552806
91MP0005423_abnormal_somatic_nervous0.97313503
92MP0002009_preneoplasia0.96176801
93MP0000163_abnormal_cartilage_morphology0.94949511
94MP0002114_abnormal_axial_skeleton0.93930740
95MP0002111_abnormal_tail_morphology0.91327828
96MP0005248_abnormal_Harderian_gland0.90500081
97MP0003941_abnormal_skin_development0.90331495
98* MP0003861_abnormal_nervous_system0.89367339
99MP0002115_abnormal_skeleton_extremities0.87595422
100MP0003938_abnormal_ear_development0.87112582
101MP0004270_analgesia0.86568734
102MP0005330_cardiomyopathy0.86477035
103MP0002109_abnormal_limb_morphology0.86333003
104MP0010094_abnormal_chromosome_stability0.85634776
105MP0003385_abnormal_body_wall0.85275350
106MP0008007_abnormal_cellular_replicative0.85001109
107MP0003137_abnormal_impulse_conducting0.84450064
108MP0003279_aneurysm0.84288457
109MP0005503_abnormal_tendon_morphology0.83732641
110MP0001730_embryonic_growth_arrest0.83628663
111MP0010307_abnormal_tumor_latency0.83589341
112MP0000579_abnormal_nail_morphology0.82874422
113MP0002086_abnormal_extraembryonic_tissu0.81772904
114MP0000537_abnormal_urethra_morphology0.81607141
115MP0005380_embryogenesis_phenotype0.81321631
116MP0001672_abnormal_embryogenesis/_devel0.81321631
117MP0003935_abnormal_craniofacial_develop0.80336919
118MP0000681_abnormal_thyroid_gland0.79989770
119MP0000432_abnormal_head_morphology0.78245124
120MP0003937_abnormal_limbs/digits/tail_de0.77218333
121MP0001661_extended_life_span0.75961260
122MP0002127_abnormal_cardiovascular_syste0.75705651
123MP0002332_abnormal_exercise_endurance0.75514688
124MP0009053_abnormal_anal_canal0.74760824
125MP0003136_yellow_coat_color0.73437672
126MP0010678_abnormal_skin_adnexa0.73156356
127MP0009384_cardiac_valve_regurgitation0.73041937
128MP0005171_absent_coat_pigmentation0.70541050
129MP0001286_abnormal_eye_development0.70496924
130MP0003634_abnormal_glial_cell0.70061116
131MP0000955_abnormal_spinal_cord0.69184982
132MP0002160_abnormal_reproductive_system0.69137386
133MP0002254_reproductive_system_inflammat0.68430652
134MP0000350_abnormal_cell_proliferation0.67891509
135MP0002752_abnormal_somatic_nervous0.67751025
136MP0006036_abnormal_mitochondrial_physio0.67654869
137MP0000383_abnormal_hair_follicle0.67280043
138MP0002081_perinatal_lethality0.66948533
139MP0002088_abnormal_embryonic_growth/wei0.66476096
140MP0003984_embryonic_growth_retardation0.66131481

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.29716064
2Aplasia/Hypoplasia of the pubic bone (HP:0009104)6.21115102
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.81532202
4Nemaline bodies (HP:0003798)5.61281478
5Hypoplastic ischia (HP:0003175)5.32972758
6Type 1 muscle fiber predominance (HP:0003803)4.90589116
7Epiphyseal dysplasia (HP:0002656)4.80067614
8Abnormality of the ischium (HP:0003174)4.51929436
9Exercise-induced myalgia (HP:0003738)4.49894865
10Abnormality of the pubic bones (HP:0003172)4.03580176
11Exercise-induced muscle cramps (HP:0003710)3.90442351
12Distal arthrogryposis (HP:0005684)3.88420494
13Mixed hearing impairment (HP:0000410)3.87382718
14Anomalous pulmonary venous return (HP:0010772)3.66430896
15Myopathic facies (HP:0002058)3.64897150
16Difficulty running (HP:0009046)3.25818315
17Round ear (HP:0100830)3.22223603
18Muscle fiber splitting (HP:0003555)3.21170572
19Ulnar deviation of the wrist (HP:0003049)3.19811263
20Abnormality of the pulmonary veins (HP:0011718)3.12891242
21Double outlet right ventricle (HP:0001719)3.10978093
22Congenital malformation of the right heart (HP:0011723)3.10978093
23Vertebral clefting (HP:0008428)3.03727393
24Abnormal vertebral ossification (HP:0100569)3.02453918
25Humeroradial synostosis (HP:0003041)3.01212886
26Synostosis involving the elbow (HP:0003938)3.01212886
27Calcaneovalgus deformity (HP:0001848)3.01042639
28Bell-shaped thorax (HP:0001591)2.91397843
29Centrally nucleated skeletal muscle fibers (HP:0003687)2.86011051
30Muscle hypertrophy of the lower extremities (HP:0008968)2.85211119
31Ulnar bowing (HP:0003031)2.83498291
32Turricephaly (HP:0000262)2.81862823
33Deformed tarsal bones (HP:0008119)2.81359126
34Oligodactyly (HP:0012165)2.80613175
35Distal lower limb amyotrophy (HP:0008944)2.78372801
36Bilateral microphthalmos (HP:0007633)2.77926589
37Abnormal ventriculo-arterial connection (HP:0011563)2.72350891
38Transposition of the great arteries (HP:0001669)2.72350891
39Abnormal connection of the cardiac segments (HP:0011545)2.72350891
40Hip contracture (HP:0003273)2.70219749
41Abnormality of the aortic arch (HP:0012303)2.68235377
42Stridor (HP:0010307)2.67872541
43Bulbar palsy (HP:0001283)2.60935684
44Distal lower limb muscle weakness (HP:0009053)2.60800748
45Abnormality of the calf musculature (HP:0001430)2.57484171
46Premature rupture of membranes (HP:0001788)2.55855354
47Calf muscle hypertrophy (HP:0008981)2.55311401
48Glossoptosis (HP:0000162)2.53849730
49Unilateral renal agenesis (HP:0000122)2.51202696
50Truncus arteriosus (HP:0001660)2.51186834
51Difficulty climbing stairs (HP:0003551)2.50132411
52Irregular epiphyses (HP:0010582)2.46464266
53Abnormality of skeletal muscle fiber size (HP:0012084)2.45389929
54Exostoses (HP:0100777)2.43904376
55Achilles tendon contracture (HP:0001771)2.43526350
56Pelvic girdle muscle weakness (HP:0003749)2.39600529
57Mild short stature (HP:0003502)2.36584088
58Broad distal phalanx of finger (HP:0009836)2.36401414
59Adducted thumb (HP:0001181)2.36283523
60Myoglobinuria (HP:0002913)2.35765027
61Shoulder girdle muscle weakness (HP:0003547)2.35053017
62Thin ribs (HP:0000883)2.32344444
63Lower limb amyotrophy (HP:0007210)2.31620016
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29868803
65Limited hip movement (HP:0008800)2.26989637
66EMG: myopathic abnormalities (HP:0003458)2.25851847
67Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.25009433
68Absent epiphyses (HP:0010577)2.25009433
69Muscle stiffness (HP:0003552)2.23440465
70Abnormality of the phalanges of the hallux (HP:0010057)2.22520930
71Trismus (HP:0000211)2.22426501
72Abnormality of the intervertebral disk (HP:0005108)2.22063954
73Abnormality of the musculature of the pelvis (HP:0001469)2.21874681
74Abnormality of the hip-girdle musculature (HP:0001445)2.21874681
75Spinal rigidity (HP:0003306)2.21116164
76Increased variability in muscle fiber diameter (HP:0003557)2.20695343
77Mildly elevated creatine phosphokinase (HP:0008180)2.17718517
78Abnormal finger flexion creases (HP:0006143)2.17647922
79Breast hypoplasia (HP:0003187)2.16635849
80Abnormality of the calcaneus (HP:0008364)2.15122591
81Megalencephaly (HP:0001355)2.14733781
82Shallow orbits (HP:0000586)2.13872155
83Proximal amyotrophy (HP:0007126)2.12396296
84Ragged-red muscle fibers (HP:0003200)2.12007726
85Enlarged epiphyses (HP:0010580)2.11419774
86Myotonia (HP:0002486)2.10445168
87Periauricular skin pits (HP:0100277)2.10403411
88Preauricular pit (HP:0004467)2.10403411
89Hyporeflexia of lower limbs (HP:0002600)2.09259000
90Vitreoretinal degeneration (HP:0000655)2.06670927
91Neck muscle weakness (HP:0000467)2.06649615
92Neonatal short-limb short stature (HP:0008921)2.04828363
93Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.03867688
94Abnormality of the umbilical cord (HP:0010881)2.03702242
95Abnormal number of incisors (HP:0011064)2.03621813
96Abnormality of the Achilles tendon (HP:0005109)2.03456497
97Abnormality of the distal phalanx of the thumb (HP:0009617)1.99493692
98Rimmed vacuoles (HP:0003805)1.98455508
99Absent phalangeal crease (HP:0006109)1.98004631
100Synostosis of carpal bones (HP:0005048)1.97906835
101Vertebral compression fractures (HP:0002953)1.97836180
102Rhizomelia (HP:0008905)1.96248990
103Increased connective tissue (HP:0009025)1.94796287
104Slender long bone (HP:0003100)1.94743755
105Coronal craniosynostosis (HP:0004440)1.93114884
106Protrusio acetabuli (HP:0003179)1.92471370
107Generalized amyotrophy (HP:0003700)1.91870315
108Hyperthyroidism (HP:0000836)1.91671814
109Ulnar deviation of finger (HP:0009465)1.89845286
110Congenital hip dislocation (HP:0001374)1.89814359
111Aplasia involving bones of the extremities (HP:0009825)1.89527927
112Aplasia involving bones of the upper limbs (HP:0009823)1.89527927
113Aplasia of the phalanges of the hand (HP:0009802)1.89527927
114Asymmetric septal hypertrophy (HP:0001670)1.87050870
115Cerebral aneurysm (HP:0004944)1.85249400
116Birth length less than 3rd percentile (HP:0003561)1.81826407
117Progressive muscle weakness (HP:0003323)1.81302161
118Hypoplastic heart (HP:0001961)1.81195078
119Short palpebral fissure (HP:0012745)1.79878909
120Hyperacusis (HP:0010780)1.77635367
121Fetal akinesia sequence (HP:0001989)1.76926082
122Small epiphyses (HP:0010585)1.76472765
123Breech presentation (HP:0001623)1.76248377
124Limb-girdle muscle atrophy (HP:0003797)1.75765539
125Infantile muscular hypotonia (HP:0008947)1.75018970
126Rhabdomyolysis (HP:0003201)1.73895660
127Waddling gait (HP:0002515)1.73846926
128Metatarsus adductus (HP:0001840)1.71325999
129Fused cervical vertebrae (HP:0002949)1.70401782
130Platyspondyly (HP:0000926)1.69302905
131Frequent falls (HP:0002359)1.68972684
132EMG: neuropathic changes (HP:0003445)1.68630830
133Areflexia of lower limbs (HP:0002522)1.67195341
134Scapular winging (HP:0003691)1.67045906
135Abnormality of the lower motor neuron (HP:0002366)1.66686499
136Biconcave vertebral bodies (HP:0004586)1.66384750
137Sprengel anomaly (HP:0000912)1.65836531
138Nasal speech (HP:0001611)1.65447487
139Partial duplication of the phalanx of hand (HP:0009999)1.65434451
140Fibular aplasia (HP:0002990)1.65014710
141Abnormality of the tricuspid valve (HP:0001702)1.64513473
142Limb-girdle muscle weakness (HP:0003325)1.64307010
143Bowel incontinence (HP:0002607)1.63652736
144Hypoplasia of the fovea (HP:0007750)1.63263927
145Aplasia/Hypoplasia of the fovea (HP:0008060)1.63263927
146Tarsal synostosis (HP:0008368)1.62825002
147Subaortic stenosis (HP:0001682)1.62246806
148Abnormality of the left ventricular outflow tract (HP:0011103)1.62246806
149Rib fusion (HP:0000902)1.62026944
150Abnormal large intestine physiology (HP:0012700)1.61991459
151Malignant hyperthermia (HP:0002047)1.61701288
152Partial duplication of thumb phalanx (HP:0009944)1.61642892
153Ankle contracture (HP:0006466)1.61220731
154Hypoplastic left heart (HP:0004383)1.61219432
155Pterygium (HP:0001059)1.60514953
156Maternal diabetes (HP:0009800)1.60045297
157Skin pits (HP:0100276)1.59690991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR28.54956807
2OBSCN4.69006656
3TRIB33.57328072
4PHKG23.47000629
5PHKG13.47000629
6SMG13.38455665
7NME23.33272946
8IRAK32.79736358
9PKN22.77993430
10MAP3K102.71839917
11TTN2.42651905
12BUB12.09501517
13PRPF4B1.99252643
14TYRO31.88065104
15BRSK11.87491588
16ICK1.87035147
17LATS21.76091711
18TAOK21.75993987
19SIK11.63675707
20CDC71.59600871
21PNCK1.57421156
22BRAF1.49706988
23LATS11.46448970
24DYRK1B1.42407662
25NEK11.41713005
26EEF2K1.41431077
27VRK21.38198208
28MAP3K111.33647895
29CAMK1D1.33174284
30ARAF1.32024460
31NME11.22555058
32AURKA1.21616799
33LMTK21.18710694
34MARK11.16982694
35TESK11.16709695
36PDGFRA1.15331242
37PRKD31.11901876
38DYRK31.09520625
39TSSK61.06857732
40NTRK21.06412328
41TAOK11.05743226
42PBK1.05340346
43CDK121.05270667
44PAK61.03169529
45UHMK11.02344466
46RIPK11.02251474
47TTK1.01681026
48BMX1.00808831
49CHEK20.99564866
50BRSK20.98576937
51MAPK150.94454225
52SCYL20.90287077
53KSR20.89930917
54FGFR10.89417305
55PAK40.89166352
56MAP3K90.86693734
57DMPK0.86553935
58ILK0.85705705
59CDK60.85329554
60PDK40.84956852
61PDK30.84956852
62AKT20.82695479
63MAP3K70.79408716
64FGFR30.78498257
65NEK20.76689801
66PIM20.76040181
67LRRK20.75711706
68MATK0.75615045
69KDR0.75537565
70LIMK10.74208090
71TAF10.73543430
72PINK10.72945842
73ERBB20.71884672
74BCKDK0.71206359
75PIK3CG0.70990255
76MAPKAPK50.68713202
77CDK80.68468510
78RPS6KA20.66699115
79ALK0.66127265
80ABL20.63595625
81MAP2K40.63426090
82IRAK20.63250890
83MTOR0.62172772
84PTK60.61731542
85STK40.61132532
86PAK20.60118704
87KSR10.59223621
88MAPKAPK30.59061269
89MAP3K10.56106843
90CDK11A0.52830803
91MUSK0.52703260
92DAPK30.51524317
93MKNK20.50827707
94PKN10.50801005
95CDK150.50655319
96PRKAA10.50650903
97EPHB20.48170044
98CAMK2G0.48152924
99ERBB30.47266891
100MAP2K20.46544967
101PLK40.46339954
102TESK20.46284438
103AURKB0.45935813
104RPS6KL10.45822803
105RPS6KC10.45822803
106MAP3K60.45705500
107PLK10.45052545
108CAMKK10.44358902
109PDPK10.43859125
110MAPK120.43235864
111PAK10.42621925
112CSNK1G30.42042991
113PTK20.41966194
114MAPK110.41483248
115MAP3K80.40563414
116NTRK10.40081939
117CDK180.40066340
118IRAK10.40028312
119BRD40.39852981
120RPS6KA60.39628597
121DYRK20.39254101
122MKNK10.38599775
123STK30.38566869
124TRPM70.37858939
125RET0.37289585
126CAMK1G0.36697701
127RPS6KA10.36665347
128WEE10.36296738
129HIPK20.35960595
130MAP2K30.35827955
131SIK20.34351791
132CDK40.34052605
133ERN10.32435848
134MAP3K40.31694566
135CDK70.31388689
136RPS6KB20.30965704
137CSNK1G10.30150546
138YES10.29577113
139FLT30.29171701
140ERBB40.28956160
141MARK30.28889674
142DYRK1A0.27985257
143CSNK1A1L0.27769433
144CDK20.27614777
145CDK140.27582882
146GSK3A0.26545228
147MAPK100.26499065
148PDGFRB0.26122596
149ROCK10.25071461
150CHEK10.24605151
151CSNK1G20.24294243
152MOS0.23923961
153DAPK20.23510183
154RPS6KA30.23425476

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.29525591
2Other types of O-glycan biosynthesis_Homo sapiens_hsa005143.37832543
3Notch signaling pathway_Homo sapiens_hsa043302.90189561
4DNA replication_Homo sapiens_hsa030302.46810827
5Fatty acid biosynthesis_Homo sapiens_hsa000612.24227901
6* Hippo signaling pathway_Homo sapiens_hsa043902.23268826
7* Basal cell carcinoma_Homo sapiens_hsa052172.12854074
8Dorso-ventral axis formation_Homo sapiens_hsa043201.93765887
9Bladder cancer_Homo sapiens_hsa052191.91126996
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85902752
11Arginine and proline metabolism_Homo sapiens_hsa003301.83523456
12* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.74913869
13Hedgehog signaling pathway_Homo sapiens_hsa043401.73120624
14TGF-beta signaling pathway_Homo sapiens_hsa043501.69236654
15Central carbon metabolism in cancer_Homo sapiens_hsa052301.68101374
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.65134359
17Pentose phosphate pathway_Homo sapiens_hsa000301.64612061
18Dilated cardiomyopathy_Homo sapiens_hsa054141.63969416
19Prion diseases_Homo sapiens_hsa050201.60849644
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.60546303
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54955516
22Vitamin B6 metabolism_Homo sapiens_hsa007501.54740284
23Tight junction_Homo sapiens_hsa045301.52906120
24mTOR signaling pathway_Homo sapiens_hsa041501.52193958
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50823095
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.50326591
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48266828
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.48152254
29Chronic myeloid leukemia_Homo sapiens_hsa052201.46600391
30Insulin signaling pathway_Homo sapiens_hsa049101.42757090
31Focal adhesion_Homo sapiens_hsa045101.40465481
32Biosynthesis of amino acids_Homo sapiens_hsa012301.29830067
33Endometrial cancer_Homo sapiens_hsa052131.27868977
34MicroRNAs in cancer_Homo sapiens_hsa052061.27555771
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27150000
36* Wnt signaling pathway_Homo sapiens_hsa043101.27124896
37ECM-receptor interaction_Homo sapiens_hsa045121.26030226
38Protein digestion and absorption_Homo sapiens_hsa049741.25608687
39Folate biosynthesis_Homo sapiens_hsa007901.23753742
40Pyrimidine metabolism_Homo sapiens_hsa002401.22186153
41ErbB signaling pathway_Homo sapiens_hsa040121.20226086
42* Proteoglycans in cancer_Homo sapiens_hsa052051.19996282
43mRNA surveillance pathway_Homo sapiens_hsa030151.18447462
44Glioma_Homo sapiens_hsa052141.18093082
45Colorectal cancer_Homo sapiens_hsa052101.18049840
46Fructose and mannose metabolism_Homo sapiens_hsa000511.17308361
47Viral myocarditis_Homo sapiens_hsa054161.14875300
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14460828
49Adherens junction_Homo sapiens_hsa045201.14237986
50RNA transport_Homo sapiens_hsa030131.12813613
51Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12346230
52Insulin resistance_Homo sapiens_hsa049311.10984814
53Circadian rhythm_Homo sapiens_hsa047101.10028025
54Mismatch repair_Homo sapiens_hsa034301.07455374
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06981024
56Neurotrophin signaling pathway_Homo sapiens_hsa047221.06617178
57Renal cell carcinoma_Homo sapiens_hsa052111.06282278
58Glucagon signaling pathway_Homo sapiens_hsa049221.05542666
59Arginine biosynthesis_Homo sapiens_hsa002201.05461155
60VEGF signaling pathway_Homo sapiens_hsa043701.04752080
61* Melanogenesis_Homo sapiens_hsa049161.04008290
62Thyroid cancer_Homo sapiens_hsa052160.99707034
63Cardiac muscle contraction_Homo sapiens_hsa042600.98933924
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97814885
65Oocyte meiosis_Homo sapiens_hsa041140.96648536
66Spliceosome_Homo sapiens_hsa030400.95734953
67HIF-1 signaling pathway_Homo sapiens_hsa040660.95301598
68Oxytocin signaling pathway_Homo sapiens_hsa049210.93631490
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92378272
70AMPK signaling pathway_Homo sapiens_hsa041520.90951706
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90455558
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.89925139
73Nitrogen metabolism_Homo sapiens_hsa009100.89203995
74Axon guidance_Homo sapiens_hsa043600.88338698
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86821433
76GnRH signaling pathway_Homo sapiens_hsa049120.86401607
77Pyruvate metabolism_Homo sapiens_hsa006200.86162174
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85265165
79Carbon metabolism_Homo sapiens_hsa012000.83037307
80Estrogen signaling pathway_Homo sapiens_hsa049150.82916084
81Non-small cell lung cancer_Homo sapiens_hsa052230.82828984
82Nucleotide excision repair_Homo sapiens_hsa034200.82679265
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82182416
84Lysine degradation_Homo sapiens_hsa003100.80369470
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.79151401
86Gap junction_Homo sapiens_hsa045400.79022394
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78608778
88Fatty acid metabolism_Homo sapiens_hsa012120.78542715
89Long-term depression_Homo sapiens_hsa047300.76879900
90Other glycan degradation_Homo sapiens_hsa005110.75792173
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75306450
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74970870
93Small cell lung cancer_Homo sapiens_hsa052220.73455074
94Cell cycle_Homo sapiens_hsa041100.73395118
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73123470
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72555973
97Parkinsons disease_Homo sapiens_hsa050120.72255719
98Fanconi anemia pathway_Homo sapiens_hsa034600.71562501
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71296243
100Alzheimers disease_Homo sapiens_hsa050100.71146151
101FoxO signaling pathway_Homo sapiens_hsa040680.70060117
102Huntingtons disease_Homo sapiens_hsa050160.69689992
103Melanoma_Homo sapiens_hsa052180.69652430
104Ribosome_Homo sapiens_hsa030100.68478782
105MAPK signaling pathway_Homo sapiens_hsa040100.68330483
106Galactose metabolism_Homo sapiens_hsa000520.67972055
107* Pathways in cancer_Homo sapiens_hsa052000.67130598
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67079621
109Pancreatic cancer_Homo sapiens_hsa052120.65431581
110Fatty acid elongation_Homo sapiens_hsa000620.65012897
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64577706
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61433873
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60681050
114* HTLV-I infection_Homo sapiens_hsa051660.59836291
115Vibrio cholerae infection_Homo sapiens_hsa051100.59122348
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58465847
117Oxidative phosphorylation_Homo sapiens_hsa001900.57357417
118Phenylalanine metabolism_Homo sapiens_hsa003600.57258964
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55394021
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55189178
121Prolactin signaling pathway_Homo sapiens_hsa049170.54684448
122Base excision repair_Homo sapiens_hsa034100.54161354
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54155193
124Calcium signaling pathway_Homo sapiens_hsa040200.54053399
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53919544
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53831922
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51653762
128Long-term potentiation_Homo sapiens_hsa047200.51379333
129Gastric acid secretion_Homo sapiens_hsa049710.51346351
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50741015
131Prostate cancer_Homo sapiens_hsa052150.48042861
132Choline metabolism in cancer_Homo sapiens_hsa052310.47188242
133Acute myeloid leukemia_Homo sapiens_hsa052210.46594534
134p53 signaling pathway_Homo sapiens_hsa041150.45600148
135N-Glycan biosynthesis_Homo sapiens_hsa005100.42888865
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.41571388
137Sulfur metabolism_Homo sapiens_hsa009200.39789546

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