FZR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ATP (GO:0071318)8.57148224
2adenosine receptor signaling pathway (GO:0001973)8.34668920
3GDP-mannose metabolic process (GO:0019673)8.31351891
4DNA strand renaturation (GO:0000733)7.26405347
5regulation of skeletal muscle contraction (GO:0014819)7.01884032
6regulation of synapse structural plasticity (GO:0051823)6.64742838
7peptidyl-glutamic acid carboxylation (GO:0017187)6.64438010
8protein carboxylation (GO:0018214)6.64438010
9G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)6.56688593
10negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)6.10254225
11positive regulation of protein kinase C signaling (GO:0090037)5.71680080
12purinergic nucleotide receptor signaling pathway (GO:0035590)5.65681589
13adenine nucleotide transport (GO:0051503)5.47880155
14regulation of cytokine production involved in inflammatory response (GO:1900015)5.24971439
15UV protection (GO:0009650)5.13825820
16mannose metabolic process (GO:0006013)5.13458851
17protein localization to kinetochore (GO:0034501)5.13349985
18protein localization to chromosome, centromeric region (GO:0071459)5.05239439
19purine ribonucleotide transport (GO:0015868)4.99321889
20response to ATP (GO:0033198)4.90088077
21mitotic sister chromatid segregation (GO:0000070)4.83296422
22mitotic cell cycle arrest (GO:0071850)4.79557084
23mitotic metaphase plate congression (GO:0007080)4.77469060
24G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.73939916
25sensory perception of taste (GO:0050909)4.71759889
26purinergic receptor signaling pathway (GO:0035587)4.66600888
27semaphorin-plexin signaling pathway (GO:0071526)4.43552014
28positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.38454001
29regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.37693784
30attachment of spindle microtubules to kinetochore (GO:0008608)4.32468693
31sister chromatid segregation (GO:0000819)4.28961564
32purine nucleotide transport (GO:0015865)4.24241696
33urinary tract smooth muscle contraction (GO:0014848)4.18640180
34viral transcription (GO:0019083)4.11824360
35metaphase plate congression (GO:0051310)4.08920316
36rRNA methylation (GO:0031167)4.01833724
37translational termination (GO:0006415)4.01794836
38positive regulation of heat generation (GO:0031652)3.99925138
39negative regulation of interleukin-8 production (GO:0032717)3.99405947
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.93092020
41establishment of chromosome localization (GO:0051303)3.89336651
42granulocyte differentiation (GO:0030851)3.89292824
43DNA strand elongation involved in DNA replication (GO:0006271)3.88001920
44endocytic recycling (GO:0032456)3.85195672
45DNA unwinding involved in DNA replication (GO:0006268)3.84841868
46microtubule depolymerization (GO:0007019)3.83956691
47melanin biosynthetic process (GO:0042438)3.77465747
48negative regulation of chromosome segregation (GO:0051985)3.76226450
49protein localization to chromosome (GO:0034502)3.74841583
50phosphatidylglycerol biosynthetic process (GO:0006655)3.73447685
51regulation of spindle organization (GO:0090224)3.73291890
52regulation of chromosome segregation (GO:0051983)3.73070574
53DNA replication initiation (GO:0006270)3.72415539
54negative regulation of mitotic sister chromatid segregation (GO:0033048)3.72214691
55negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.72214691
56negative regulation of sister chromatid segregation (GO:0033046)3.72214691
57negative regulation of mitotic sister chromatid separation (GO:2000816)3.72214691
58ribosomal small subunit assembly (GO:0000028)3.71184924
59DNA damage response, signal transduction resulting in transcription (GO:0042772)3.70544214
60spindle checkpoint (GO:0031577)3.69879195
61DNA strand elongation (GO:0022616)3.68448140
62histone phosphorylation (GO:0016572)3.67396905
63negative regulation of DNA-templated transcription, elongation (GO:0032785)3.66643271
64negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.66643271
65spindle assembly checkpoint (GO:0071173)3.66023809
66mitotic spindle assembly checkpoint (GO:0007094)3.65383085
67negative regulation of erythrocyte differentiation (GO:0045647)3.65243414
68nucleoside transmembrane transport (GO:1901642)3.64615551
69mitotic chromosome condensation (GO:0007076)3.64233988
70negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.63116969
71translational elongation (GO:0006414)3.62831880
72transepithelial transport (GO:0070633)3.57671332
73DNA replication checkpoint (GO:0000076)3.55521730
74CENP-A containing nucleosome assembly (GO:0034080)3.55399041
75chromatin remodeling at centromere (GO:0031055)3.55023769
76regulation of protein kinase A signaling (GO:0010738)3.54873933
77telomere maintenance via semi-conservative replication (GO:0032201)3.52834463
78DNA replication-dependent nucleosome organization (GO:0034723)3.52741681
79DNA replication-dependent nucleosome assembly (GO:0006335)3.52741681
80regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.52552981
81melanin metabolic process (GO:0006582)3.50520655
82translational initiation (GO:0006413)3.48603133
83nucleotide-sugar biosynthetic process (GO:0009226)3.48330786
84ribosomal small subunit biogenesis (GO:0042274)3.47838376
85mitotic spindle checkpoint (GO:0071174)3.46111663
86regulation of exit from mitosis (GO:0007096)3.45484916
87maturation of SSU-rRNA (GO:0030490)3.44040245
88kinetochore organization (GO:0051383)3.43990760
89DNA replication-independent nucleosome organization (GO:0034724)3.43411234
90DNA replication-independent nucleosome assembly (GO:0006336)3.43411234
91protein retention in ER lumen (GO:0006621)3.42639938
92sex determination (GO:0007530)3.40655328
93protoporphyrinogen IX metabolic process (GO:0046501)3.40090436
94nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.40059195
95protein K6-linked ubiquitination (GO:0085020)3.38770817
96cellular protein complex disassembly (GO:0043624)3.37030775
97sphingomyelin metabolic process (GO:0006684)3.36547891
98mitotic nuclear envelope disassembly (GO:0007077)3.35538243
99cellular response to virus (GO:0098586)3.34284759
100regulation of mitotic metaphase/anaphase transition (GO:0030071)3.33993929
101kinetochore assembly (GO:0051382)3.33072279
102modulation by virus of host process (GO:0019054)3.33055778
103regulation of mitotic sister chromatid separation (GO:0010965)3.30244880
104regulation of mitotic sister chromatid segregation (GO:0033047)3.30244880
105regulation of sister chromatid segregation (GO:0033045)3.30244880
106planar cell polarity pathway involved in neural tube closure (GO:0090179)3.30170529
107proline biosynthetic process (GO:0006561)3.29397885
108DNA deamination (GO:0045006)3.28712468
109regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.27832526
110protein complex disassembly (GO:0043241)3.26979272
111protein complex localization (GO:0031503)3.26385473
112protein insertion into membrane (GO:0051205)3.25927304
113negative regulation of toll-like receptor signaling pathway (GO:0034122)3.25255392
114cell migration in hindbrain (GO:0021535)3.20812155
115chromosome segregation (GO:0007059)3.18754462
116protoporphyrinogen IX biosynthetic process (GO:0006782)3.16041374
117regulation of mitotic spindle organization (GO:0060236)3.15814719
118SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14864764
119viral life cycle (GO:0019058)3.14607393
120rRNA modification (GO:0000154)3.14188090
121regulation of phospholipid biosynthetic process (GO:0071071)3.13288968
122regulation of hydrogen peroxide metabolic process (GO:0010310)3.12820847
123peristalsis (GO:0030432)3.12699336
124membrane disassembly (GO:0030397)3.12670703
125nuclear envelope disassembly (GO:0051081)3.12670703
126regulation of sister chromatid cohesion (GO:0007063)3.12585835
127DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.11840738
128negative regulation of tumor necrosis factor production (GO:0032720)3.11269859
129sphingosine metabolic process (GO:0006670)3.10946364
130chromatin assembly or disassembly (GO:0006333)3.10470388
131histone exchange (GO:0043486)3.10442077
132cotranslational protein targeting to membrane (GO:0006613)3.09106221
133macromolecular complex disassembly (GO:0032984)3.07813067
134modulation by symbiont of host cellular process (GO:0044068)3.07812260
135protein targeting to ER (GO:0045047)3.05561457
136sulfur amino acid catabolic process (GO:0000098)3.05261525
137nucleotide transmembrane transport (GO:1901679)3.04270320
138folic acid metabolic process (GO:0046655)3.03014012
139negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.02691246
140actin filament bundle organization (GO:0061572)2.99630018
141actin filament bundle assembly (GO:0051017)2.99630018
142regulation of telomere maintenance via telomerase (GO:0032210)2.99302873
143negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.99149798
144phosphate ion transmembrane transport (GO:0035435)2.99062697
145telomere maintenance via telomere lengthening (GO:0010833)2.98977579
146maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.98649220
147regulation of ARF GTPase activity (GO:0032312)2.98478802
148regulation of interferon-beta biosynthetic process (GO:0045357)2.97603081
149positive regulation of chromosome segregation (GO:0051984)2.97125522
150telomere maintenance via recombination (GO:0000722)2.97025188
151grooming behavior (GO:0007625)2.96879908
152mitotic recombination (GO:0006312)2.96542442
153pre-miRNA processing (GO:0031054)2.96159303
154peptidyl-arginine omega-N-methylation (GO:0035247)2.95433086
155regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.92399679
156ribosomal large subunit biogenesis (GO:0042273)2.91994054
157negative regulation of mitosis (GO:0045839)2.91292136
158establishment of protein localization to endoplasmic reticulum (GO:0072599)2.91163070
159formation of translation preinitiation complex (GO:0001731)2.90370645
160detection of light stimulus involved in visual perception (GO:0050908)2.90275386
161detection of light stimulus involved in sensory perception (GO:0050962)2.90275386
162meiotic chromosome segregation (GO:0045132)2.88899983
163type B pancreatic cell proliferation (GO:0044342)2.87711709
164negative regulation of proteasomal protein catabolic process (GO:1901799)2.87351176
165spliceosomal snRNP assembly (GO:0000387)2.86481267
166regulation of chromatin binding (GO:0035561)2.85706311
167nucleotide-excision repair, DNA gap filling (GO:0006297)2.85131681
168diol metabolic process (GO:0034311)2.84859192
169negative regulation of RNA splicing (GO:0033119)2.84636742
1703-UTR-mediated mRNA stabilization (GO:0070935)2.84571891
171chromosome condensation (GO:0030261)2.83867531
172estrogen biosynthetic process (GO:0006703)2.83726285
173regulation of type I interferon-mediated signaling pathway (GO:0060338)2.82923604
174cardiolipin metabolic process (GO:0032048)2.81820688
175negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.81383879
176sialylation (GO:0097503)2.81044942
177cellular anion homeostasis (GO:0030002)2.80556723
178nucleoside bisphosphate biosynthetic process (GO:0033866)2.80477169
179purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.80477169
180ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.80477169
181protein localization to endoplasmic reticulum (GO:0070972)2.78345839
182protein-DNA complex disassembly (GO:0032986)2.77220066
183response to peptidoglycan (GO:0032494)2.76255545
184response to muramyl dipeptide (GO:0032495)2.71356692
185regulation of heat generation (GO:0031650)2.67134183
186neuromuscular synaptic transmission (GO:0007274)2.65209487
187secondary metabolite biosynthetic process (GO:0044550)2.64249692
188nucleoside transport (GO:0015858)2.63804249
189gonadal mesoderm development (GO:0007506)2.59529512
190G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.59283844
191phosphatidylethanolamine biosynthetic process (GO:0006646)2.58862489
192positive thymic T cell selection (GO:0045059)2.58135546
193mitochondrion distribution (GO:0048311)2.57533102
194activation of adenylate cyclase activity (GO:0007190)2.56998585
195trivalent inorganic anion homeostasis (GO:0072506)2.55293246
196phosphate ion homeostasis (GO:0055062)2.55293246
197synaptic vesicle docking involved in exocytosis (GO:0016081)2.52903567
198proline metabolic process (GO:0006560)2.50672909
199behavioral response to pain (GO:0048266)2.50263363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.76807302
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.00483074
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.01851085
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.67534980
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.64252261
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.47890826
7LXR_22292898_ChIP-Seq_THP-1_Human3.26416617
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.25089272
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81936579
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.72648942
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.63393918
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50397391
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47603469
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.44912366
15XRN2_22483619_ChIP-Seq_HELA_Human2.44517909
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.43103168
17RACK7_27058665_Chip-Seq_MCF-7_Human2.36817746
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34169188
19MAF_26560356_Chip-Seq_TH2_Human2.33225884
20MYC_22102868_ChIP-Seq_BL_Human2.31064570
21VDR_24763502_ChIP-Seq_THP-1_Human2.24327159
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.23659140
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.23526402
24ERG_21242973_ChIP-ChIP_JURKAT_Human2.20618014
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20197581
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.17991437
27CTCF_27219007_Chip-Seq_ERYTHROID_Human2.09702209
28MAF_26560356_Chip-Seq_TH1_Human2.07586238
29CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04196632
30GABP_17652178_ChIP-ChIP_JURKAT_Human2.01990042
31CTCF_27219007_Chip-Seq_Bcells_Human1.98699241
32* BCOR_27268052_Chip-Seq_Bcells_Human1.98278453
33* BCL6_27268052_Chip-Seq_Bcells_Human1.95220826
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94821599
35* TET1_21451524_ChIP-Seq_MESCs_Mouse1.92355884
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90374595
37MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.90231004
38E2F1_20622854_ChIP-Seq_HELA_Human1.87656898
39* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86966845
40SA1_27219007_Chip-Seq_ERYTHROID_Human1.85055740
41SMC4_20622854_ChIP-Seq_HELA_Human1.84909723
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80292449
43GABP_19822575_ChIP-Seq_HepG2_Human1.78353960
44AR_21909140_ChIP-Seq_LNCAP_Human1.78143303
45VDR_21846776_ChIP-Seq_THP-1_Human1.76809716
46CIITA_25753668_ChIP-Seq_RAJI_Human1.76239594
47PHF8_20622854_ChIP-Seq_HELA_Human1.75773782
48TTF2_22483619_ChIP-Seq_HELA_Human1.75575714
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75067867
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73339410
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.72672767
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.72472006
53* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.70634100
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70568190
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69366674
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.68565594
57* DCP1A_22483619_ChIP-Seq_HELA_Human1.67574573
58RARB_24833708_ChIP-Seq_LIVER_Mouse1.67236071
59VDR_23849224_ChIP-Seq_CD4+_Human1.67171219
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65046272
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.64528388
62* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.64072263
63RARA_24833708_ChIP-Seq_LIVER_Mouse1.62020184
64KDM2B_26808549_Chip-Seq_K562_Human1.60809627
65* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.60767478
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60144162
67CREB1_26743006_Chip-Seq_LNCaP_Human1.60128963
68ZNF263_19887448_ChIP-Seq_K562_Human1.60018826
69* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.58551792
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57757033
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57683504
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.54344304
73CTCF_21964334_Chip-Seq_Bcells_Human1.53811497
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.53756577
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53379046
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51915016
77* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51777096
78TP53_22127205_ChIP-Seq_IMR90_Human1.51602487
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50329973
80* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50228490
81RXRA_24833708_ChIP-Seq_LIVER_Mouse1.50226397
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49821145
83FOXP3_21729870_ChIP-Seq_TREG_Human1.49683667
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42960327
85KDM5A_27292631_Chip-Seq_BREAST_Human1.42250229
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.41685353
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40819821
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40231479
89* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40087908
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39085890
91CTCF_21964334_ChIP-Seq_BJAB-B_Human1.39059800
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38351467
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37867488
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37754891
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37382779
96SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36879500
97TP63_19390658_ChIP-ChIP_HaCaT_Human1.36528109
98* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36296572
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35509138
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33785206
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33629607
102EGR1_19374776_ChIP-ChIP_THP-1_Human1.32563107
103* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32046044
104PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30165711
105CTCF_20526341_ChIP-Seq_ESCs_Human1.29316374
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29185498
107ETS1_21867929_ChIP-Seq_TH2_Mouse1.28206055
108NCOR1_26117541_ChIP-Seq_K562_Human1.27921692
109SA1_27219007_Chip-Seq_Bcells_Human1.27572984
110ATF3_27146783_Chip-Seq_COLON_Human1.27165444
111ESR2_21235772_ChIP-Seq_MCF-7_Human1.26634176
112SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25988834
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25936891
114NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24151016
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22947287
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20335060
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20102991
118TP63_17297297_ChIP-ChIP_HaCaT_Human1.19491644
119* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18997425
120MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18641077
121FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18573894
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18077021
123JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.17843496
124NANOG_21062744_ChIP-ChIP_HESCs_Human1.14986032
125SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14213674
126UBF1/2_26484160_Chip-Seq_HMECs_Human1.13336982
127STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12485726
128CTCF_26484167_Chip-Seq_Bcells_Mouse1.12300192
129CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11565920
130SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10753046
131* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10670362
132TP63_22573176_ChIP-Seq_HFKS_Human1.10580929
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10358382
134STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09826808
135RUNX1_22412390_ChIP-Seq_EML_Mouse1.09546688
136TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.09211090
137SMC3_22415368_ChIP-Seq_MEFs_Mouse1.08427491
138PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07023027
139RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06421329
140POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06219816
141PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06137212
142NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05436040
143EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04759401
144POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04548085
145ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04484851
146* RUNX1_27514584_Chip-Seq_MCF-7_Human1.04004308
147CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03133520
148HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03104535
149PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02407991
150FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02379190
151SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02376078
152ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01336262
153KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00910181
154KDM2B_26808549_Chip-Seq_DND41_Human1.00133124
155SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98680712
156SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98253198
157PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98023310
158TCF7_22412390_ChIP-Seq_EML_Mouse0.96958679
159FOXP1_21924763_ChIP-Seq_HESCs_Human0.96191937
160KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95948961
161ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95564494
162FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95309714
163ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93293852
164CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92311166
165TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90732086
166TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87085691
167ELK3_25401928_ChIP-Seq_HUVEC_Human0.86505825
168GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86427717
169UTX_26944678_Chip-Seq_JUKART_Human0.86000865
170* YY1_22570637_ChIP-Seq_MALME-3M_Human0.85933570
171SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.85400069
172ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84676343
173MYC_18940864_ChIP-ChIP_HL60_Human0.84127456
174OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83825168
175P68_20966046_ChIP-Seq_HELA_Human0.83774176
176POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.82828752

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation6.99485817
2MP0001986_abnormal_taste_sensitivity5.67357091
3MP0005174_abnormal_tail_pigmentation5.59908249
4MP0005423_abnormal_somatic_nervous5.53726865
5MP0003693_abnormal_embryo_hatching5.13209036
6MP0003136_yellow_coat_color4.81000308
7* MP0003111_abnormal_nucleus_morphology4.69930640
8MP0005409_darkened_coat_color4.51303094
9MP0004957_abnormal_blastocyst_morpholog4.16226422
10MP0010094_abnormal_chromosome_stability3.92401251
11* MP0003077_abnormal_cell_cycle3.75140049
12MP0001188_hyperpigmentation3.38928651
13MP0003705_abnormal_hypodermis_morpholog2.97814367
14MP0000751_myopathy2.81795747
15MP0002653_abnormal_ependyma_morphology2.74726474
16MP0005083_abnormal_biliary_tract2.68838175
17MP0003453_abnormal_keratinocyte_physiol2.62014132
18MP0003656_abnormal_erythrocyte_physiolo2.56368008
19MP0003123_paternal_imprinting2.56030330
20MP0008057_abnormal_DNA_replication2.44890987
21MP0004381_abnormal_hair_follicle2.40939680
22MP0008932_abnormal_embryonic_tissue2.38058049
23MP0002102_abnormal_ear_morphology2.30431099
24MP0000015_abnormal_ear_pigmentation2.22668412
25MP0008058_abnormal_DNA_repair2.21157621
26MP0001968_abnormal_touch/_nociception2.13690782
27MP0008007_abnormal_cellular_replicative2.07370805
28MP0001730_embryonic_growth_arrest2.03929296
29MP0001502_abnormal_circadian_rhythm1.99408692
30* MP0000350_abnormal_cell_proliferation1.98442666
31MP0005058_abnormal_lysosome_morphology1.97645918
32MP0003121_genomic_imprinting1.89089646
33MP0001756_abnormal_urination1.88938629
34MP0006292_abnormal_olfactory_placode1.87920662
35MP0000750_abnormal_muscle_regeneration1.86917700
36MP0008877_abnormal_DNA_methylation1.75657108
37* MP0001697_abnormal_embryo_size1.71778200
38MP0003315_abnormal_perineum_morphology1.68424539
39MP0002085_abnormal_embryonic_tissue1.68389630
40MP0000490_abnormal_crypts_of1.66311999
41MP0004130_abnormal_muscle_cell1.62490757
42MP0003122_maternal_imprinting1.58809317
43MP0008875_abnormal_xenobiotic_pharmacok1.56220143
44MP0000013_abnormal_adipose_tissue1.55648906
45MP0003786_premature_aging1.55328914
46MP0000537_abnormal_urethra_morphology1.55001420
47MP0001958_emphysema1.54937381
48* MP0002080_prenatal_lethality1.54293484
49MP0002084_abnormal_developmental_patter1.53172315
50MP0001661_extended_life_span1.52905061
51MP0005330_cardiomyopathy1.52663438
52* MP0001672_abnormal_embryogenesis/_devel1.47045735
53* MP0005380_embryogenesis_phenotype1.47045735
54MP0001529_abnormal_vocalization1.46706268
55MP0010030_abnormal_orbit_morphology1.44246305
56MP0000003_abnormal_adipose_tissue1.44070278
57MP0005501_abnormal_skin_physiology1.41356087
58MP0000313_abnormal_cell_death1.39592392
59MP0002396_abnormal_hematopoietic_system1.39295600
60MP0000747_muscle_weakness1.36318619
61MP0005397_hematopoietic_system_phenotyp1.35309747
62MP0001545_abnormal_hematopoietic_system1.35309747
63MP0001929_abnormal_gametogenesis1.33761784
64MP0000538_abnormal_urinary_bladder1.32280243
65MP0003172_abnormal_lysosome_physiology1.32224599
66MP0009840_abnormal_foam_cell1.30491053
67MP0005076_abnormal_cell_differentiation1.29980700
68MP0002638_abnormal_pupillary_reflex1.28091667
69MP0003119_abnormal_digestive_system1.27494664
70MP0004808_abnormal_hematopoietic_stem1.25841782
71MP0002210_abnormal_sex_determination1.25625291
72MP0009379_abnormal_foot_pigmentation1.25364657
73MP0005257_abnormal_intraocular_pressure1.23670068
74MP0001348_abnormal_lacrimal_gland1.23382191
75MP0002736_abnormal_nociception_after1.21676723
76* MP0002086_abnormal_extraembryonic_tissu1.19915710
77MP0004197_abnormal_fetal_growth/weight/1.18396415
78MP0008995_early_reproductive_senescence1.18241903
79MP0008789_abnormal_olfactory_epithelium1.18100130
80* MP0003984_embryonic_growth_retardation1.17510610
81MP0003861_abnormal_nervous_system1.16286683
82MP0003567_abnormal_fetal_cardiomyocyte1.16190017
83MP0010307_abnormal_tumor_latency1.15414399
84MP0001145_abnormal_male_reproductive1.14456261
85* MP0002088_abnormal_embryonic_growth/wei1.14299741
86* MP0002019_abnormal_tumor_incidence1.13505810
87MP0004147_increased_porphyrin_level1.12611786
88MP0005394_taste/olfaction_phenotype1.12090207
89MP0005499_abnormal_olfactory_system1.12090207
90MP0003718_maternal_effect1.12011577
91MP0000703_abnormal_thymus_morphology1.11099128
92MP0009278_abnormal_bone_marrow1.10917078
93MP0003283_abnormal_digestive_organ1.09609825
94MP0003646_muscle_fatigue1.09435984
95MP0008770_decreased_survivor_rate1.04879822
96MP0002254_reproductive_system_inflammat1.03870336
97MP0003303_peritoneal_inflammation1.03657093
98MP0003221_abnormal_cardiomyocyte_apopto1.03643386
99MP0004185_abnormal_adipocyte_glucose1.03250973
100MP0004133_heterotaxia0.99113705
101MP0002735_abnormal_chemical_nociception0.98650100
102MP0003698_abnormal_male_reproductive0.98447862
103MP0004858_abnormal_nervous_system0.97013449
104MP0002751_abnormal_autonomic_nervous0.96727648
105MP0000653_abnormal_sex_gland0.96588226
106MP0009931_abnormal_skin_appearance0.95804122
107MP0003436_decreased_susceptibility_to0.94768079
108MP0005584_abnormal_enzyme/coenzyme_acti0.94703103
109* MP0002398_abnormal_bone_marrow0.94672074
110MP0002163_abnormal_gland_morphology0.91358284
111* MP0000358_abnormal_cell_content/0.90357488
112MP0001873_stomach_inflammation0.88637160
113MP0005375_adipose_tissue_phenotype0.87728080
114MP0001765_abnormal_ion_homeostasis0.87722931
115MP0005451_abnormal_body_composition0.84766939
116MP0003115_abnormal_respiratory_system0.83251875
117MP0002722_abnormal_immune_system0.82722430
118MP0004233_abnormal_muscle_weight0.82652729
119MP0002249_abnormal_larynx_morphology0.82132734
120MP0001664_abnormal_digestion0.81607687
121MP0005023_abnormal_wound_healing0.80152195
122MP0000367_abnormal_coat/_hair0.79769487
123MP0002933_joint_inflammation0.79134273
124MP0003938_abnormal_ear_development0.78564834
125MP0000858_altered_metastatic_potential0.76960452
126MP0001293_anophthalmia0.76347411
127MP0002161_abnormal_fertility/fecundity0.76136558
128MP0000470_abnormal_stomach_morphology0.75928258
129MP0003329_amyloid_beta_deposits0.75730352
130MP0000049_abnormal_middle_ear0.74096462
131MP0010771_integument_phenotype0.73895294
132MP0000689_abnormal_spleen_morphology0.73666050
133MP0009672_abnormal_birth_weight0.73621040
134MP0009053_abnormal_anal_canal0.73480317
135MP0003878_abnormal_ear_physiology0.73176730
136MP0005377_hearing/vestibular/ear_phenot0.73176730
137MP0000678_abnormal_parathyroid_gland0.71825626
138* MP0005384_cellular_phenotype0.71809692
139MP0005332_abnormal_amino_acid0.71355926
140MP0005365_abnormal_bile_salt0.71109738
141MP0005666_abnormal_adipose_tissue0.70514109
142MP0002282_abnormal_trachea_morphology0.69006020
143MP0002234_abnormal_pharynx_morphology0.68390797
144MP0008874_decreased_physiological_sensi0.67380091
145MP0004947_skin_inflammation0.67038871
146MP0003279_aneurysm0.66980134
147MP0009333_abnormal_splenocyte_physiolog0.65604008
148MP0002060_abnormal_skin_morphology0.65498581
149MP0001849_ear_inflammation0.65197214
150MP0004811_abnormal_neuron_physiology0.64324915
151MP0002932_abnormal_joint_morphology0.63811712
152MP0004043_abnormal_pH_regulation0.63790601
153MP0010352_gastrointestinal_tract_polyps0.63767625
154MP0003806_abnormal_nucleotide_metabolis0.63568620
155MP0000613_abnormal_salivary_gland0.63226285
156MP0008260_abnormal_autophagy0.62819714
157* MP0002429_abnormal_blood_cell0.62617279
158MP0002075_abnormal_coat/hair_pigmentati0.60977377
159MP0002114_abnormal_axial_skeleton0.60921699
160* MP0005621_abnormal_cell_physiology0.60830822
161* MP0002152_abnormal_brain_morphology0.60684721
162MP0002111_abnormal_tail_morphology0.60580001
163MP0000778_abnormal_nervous_system0.60534279
164MP0002160_abnormal_reproductive_system0.59567300
165MP0002081_perinatal_lethality0.59269952
166MP0001286_abnormal_eye_development0.58528997
167MP0004087_abnormal_muscle_fiber0.55542030
168MP0009643_abnormal_urine_homeostasis0.53830003
169MP0004019_abnormal_vitamin_homeostasis0.53559500
170MP0000759_abnormal_skeletal_muscle0.52808005
171MP0000767_abnormal_smooth_muscle0.52705086
172MP0001216_abnormal_epidermal_layer0.51774932
173MP0002796_impaired_skin_barrier0.50948743
174MP0005410_abnormal_fertilization0.47982323
175MP0003879_abnormal_hair_cell0.47588815
176MP0001970_abnormal_pain_threshold0.45656281
177MP0009384_cardiac_valve_regurgitation0.45628257
178MP0002136_abnormal_kidney_physiology0.44787562
179MP0001191_abnormal_skin_condition0.44764317
180MP0001919_abnormal_reproductive_system0.42140914
181MP0001346_abnormal_lacrimal_gland0.42116656
182MP0000685_abnormal_immune_system0.40227504
183MP0002909_abnormal_adrenal_gland0.38319130
184MP0010155_abnormal_intestine_physiology0.37929997
185MP0002089_abnormal_postnatal_growth/wei0.37647171
186MP0005025_abnormal_response_to0.37204446

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)6.21204413
2Ulnar bowing (HP:0003031)5.67643409
3Thin bony cortex (HP:0002753)5.62799426
4Annular pancreas (HP:0001734)5.39008953
5Abnormality of cells of the erythroid lineage (HP:0012130)5.21532286
6Turricephaly (HP:0000262)5.09708007
7Rectovaginal fistula (HP:0000143)5.05281356
8Rectal fistula (HP:0100590)5.05281356
9Poikiloderma (HP:0001029)4.99918333
10Intestinal fistula (HP:0100819)4.95017735
11Vaginal fistula (HP:0004320)4.83487966
12Abnormal number of erythroid precursors (HP:0012131)4.79527295
13Dyschromatopsia (HP:0007641)4.42963817
14Akinesia (HP:0002304)4.35322208
15Hemorrhage of the eye (HP:0011885)4.28215899
16Reticulocytopenia (HP:0001896)4.25902305
17Coronal craniosynostosis (HP:0004440)4.16006118
18Popliteal pterygium (HP:0009756)4.13191618
19Abnormality of the intrinsic pathway (HP:0010989)4.11588214
20Attenuation of retinal blood vessels (HP:0007843)4.03567555
21Birth length less than 3rd percentile (HP:0003561)4.00413316
22Mesangial abnormality (HP:0001966)3.96868876
23Patellar aplasia (HP:0006443)3.93527442
24Abnormality of the heme biosynthetic pathway (HP:0010472)3.93237119
25Breast hypoplasia (HP:0003187)3.91705842
26Joint hemorrhage (HP:0005261)3.87084508
27Aplasia/Hypoplasia of the patella (HP:0006498)3.70633551
28Facial diplegia (HP:0001349)3.69448734
29Anteriorly placed anus (HP:0001545)3.69132961
30Aplasia of the musculature (HP:0100854)3.56035411
31Fetal akinesia sequence (HP:0001989)3.53026864
32Delayed epiphyseal ossification (HP:0002663)3.43867688
33Prolonged partial thromboplastin time (HP:0003645)3.29752083
34Atrioventricular block (HP:0001678)3.20146598
35Joint stiffness (HP:0001387)3.13612421
36Pallor (HP:0000980)3.09031585
37Impulsivity (HP:0100710)3.07778320
38Short chin (HP:0000331)3.06770910
39Bowed forearm bones (HP:0003956)3.02243547
40Bowing of the arm (HP:0006488)3.02243547
41Choroideremia (HP:0001139)2.97273074
42Congenital stationary night blindness (HP:0007642)2.95261320
43Abnormality of the costochondral junction (HP:0000919)2.92786096
44Carpal bone hypoplasia (HP:0001498)2.91194726
45Abnormality of reticulocytes (HP:0004312)2.88814180
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.85406466
47Macrocytic anemia (HP:0001972)2.84067146
48Capillary hemangiomas (HP:0005306)2.79199209
49Insomnia (HP:0100785)2.78231495
50Bony spicule pigmentary retinopathy (HP:0007737)2.76225728
51Thin ribs (HP:0000883)2.75149368
52Ependymoma (HP:0002888)2.72970340
53Abnormality of placental membranes (HP:0011409)2.71657294
54Amniotic constriction ring (HP:0009775)2.71657294
55Selective tooth agenesis (HP:0001592)2.69470847
56Myopathic facies (HP:0002058)2.67771199
57Aplastic anemia (HP:0001915)2.66441382
58Choanal stenosis (HP:0000452)2.65169521
59Oral leukoplakia (HP:0002745)2.62822422
60Enlarged epiphyses (HP:0010580)2.61692998
61Myotonia (HP:0002486)2.61101591
62Chorioretinal atrophy (HP:0000533)2.58043299
63Absent thumb (HP:0009777)2.56750035
64Zonular cataract (HP:0010920)2.55372735
65Increased nuchal translucency (HP:0010880)2.54718728
66Hypoalbuminemia (HP:0003073)2.54385150
67Abnormal albumin level (HP:0012116)2.54385150
68Poikilocytosis (HP:0004447)2.54052156
69Basal cell carcinoma (HP:0002671)2.50381579
70Narrow nasal bridge (HP:0000446)2.47511219
71Deep palmar crease (HP:0006191)2.45510623
72Widely patent fontanelles and sutures (HP:0004492)2.44594436
73Abnormal number of incisors (HP:0011064)2.43047601
74Aplasia/Hypoplasia of the uvula (HP:0010293)2.42453187
75Neonatal onset (HP:0003623)2.41831558
76Overlapping toe (HP:0001845)2.41731993
77Duodenal stenosis (HP:0100867)2.39147394
78Small intestinal stenosis (HP:0012848)2.39147394
79Concave nail (HP:0001598)2.38369664
80Flat occiput (HP:0005469)2.37704845
81Colon cancer (HP:0003003)2.36759481
82Hypoplasia of the capital femoral epiphysis (HP:0003090)2.34207641
83Meckel diverticulum (HP:0002245)2.33433674
84Myelodysplasia (HP:0002863)2.33280202
85Hypophosphatemic rickets (HP:0004912)2.32628077
86Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.31126819
87Horseshoe kidney (HP:0000085)2.31107554
88Abdominal situs inversus (HP:0003363)2.29208491
89Abnormality of abdominal situs (HP:0011620)2.29208491
90Male infertility (HP:0003251)2.25765222
91Premature graying of hair (HP:0002216)2.25570622
92Abnormality of the preputium (HP:0100587)2.25567187
93Atresia of the external auditory canal (HP:0000413)2.25434257
94Medulloblastoma (HP:0002885)2.24826723
95Hyperacusis (HP:0010780)2.23884416
96Abnormality of the labia minora (HP:0012880)2.22780287
97Abnormality of the ileum (HP:0001549)2.22710843
98Abnormality of the common coagulation pathway (HP:0010990)2.19704343
99Rough bone trabeculation (HP:0100670)2.18034556
100Cafe-au-lait spot (HP:0000957)2.17039659
101Renal Fanconi syndrome (HP:0001994)2.15507579
102Cleft eyelid (HP:0000625)2.15306320
103Absent radius (HP:0003974)2.13703075
104Reticulocytosis (HP:0001923)2.11702109
105Abnormality of polysaccharide metabolism (HP:0011012)2.10707412
106Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10707412
107Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10707412
108Degeneration of anterior horn cells (HP:0002398)2.09783820
109Abnormality of the anterior horn cell (HP:0006802)2.09783820
110Facial hemangioma (HP:0000329)2.09670277
111Short humerus (HP:0005792)2.09228300
112High anterior hairline (HP:0009890)2.08918060
113Neoplasm of the pancreas (HP:0002894)2.07311281
114Pterygium (HP:0001059)2.05876156
115Easy fatigability (HP:0003388)2.04998308
116Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04664674
117Squamous cell carcinoma (HP:0002860)2.03445178
118Shoulder girdle muscle weakness (HP:0003547)2.03298034
119Triphalangeal thumb (HP:0001199)2.02327670
120Abnormality of chromosome stability (HP:0003220)2.01834354
121Mucopolysacchariduria (HP:0008155)2.01815466
122Urinary glycosaminoglycan excretion (HP:0003541)2.01815466
123Atrophy/Degeneration involving motor neurons (HP:0007373)2.01774279
124Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00026334
125Neonatal respiratory distress (HP:0002643)1.99974099
126Chromosomal breakage induced by crosslinking agents (HP:0003221)1.99074079
127Malignant hyperthermia (HP:0002047)1.98998977
128Aplasia involving forearm bones (HP:0009822)1.98750291
129Absent forearm bone (HP:0003953)1.98750291
130Cerebral hypomyelination (HP:0006808)1.97755512
131Increased number of teeth (HP:0011069)1.97709051
132Prominent nose (HP:0000448)1.97566864
133Cholelithiasis (HP:0001081)1.97392765
134Slender long bone (HP:0003100)1.96556880
135Tracheoesophageal fistula (HP:0002575)1.95728457
136Abnormality of the duodenum (HP:0002246)1.95543702
137Decreased central vision (HP:0007663)1.95367568
138Aplasia/Hypoplasia of the breasts (HP:0010311)1.95271474
139Abnormal atrioventricular conduction (HP:0005150)1.94953056
140Rectal prolapse (HP:0002035)1.94685835
141Cheilitis (HP:0100825)1.93730643
142Diminished movement (HP:0002374)1.93602438
143Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92693571
144Pelvic girdle muscle weakness (HP:0003749)1.92598253
145Mask-like facies (HP:0000298)1.92288789
146Rhabdomyosarcoma (HP:0002859)1.91244029
147Pointed chin (HP:0000307)1.90886708
148Spina bifida occulta (HP:0003298)1.90082850
149Chromsome breakage (HP:0040012)1.89530357
150Heart block (HP:0012722)1.89210421
15111 pairs of ribs (HP:0000878)1.88281400
152Adenoma sebaceum (HP:0009720)1.86314202
153Angiofibromas (HP:0010615)1.86314202
154Abnormal epiphyseal ossification (HP:0010656)1.85723947
155Cervical subluxation (HP:0003308)1.84345696
156Genu recurvatum (HP:0002816)1.84240307
157Neoplasm of striated muscle (HP:0009728)1.82506892
158Amyotrophic lateral sclerosis (HP:0007354)1.82489550
159Congenital hip dislocation (HP:0001374)1.82290569
160Aplasia/Hypoplasia of the sternum (HP:0006714)1.80533660
161Rib fusion (HP:0000902)1.80102532
162Sloping forehead (HP:0000340)1.79948038
163Renal duplication (HP:0000075)1.79744050
164Aplasia/hypoplasia of the humerus (HP:0006507)1.79033344
165Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78229273
166Short 4th metacarpal (HP:0010044)1.78229273
167Truncus arteriosus (HP:0001660)1.78223106
168Microretrognathia (HP:0000308)1.77438044
169Megalocornea (HP:0000485)1.77374145
170Breast aplasia (HP:0100783)1.76541171
171Absent epiphyses (HP:0010577)1.75847586
172Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75847586
173Increased hepatocellular lipid droplets (HP:0006565)1.75558414
174Premature ovarian failure (HP:0008209)1.73555768
175Abnormal lung lobation (HP:0002101)1.72739271
176Wide cranial sutures (HP:0010537)1.71804295
177Abnormality of the hepatic vasculature (HP:0006707)1.71233404
178Abnormality of the carotid arteries (HP:0005344)1.70879147
179Shawl scrotum (HP:0000049)1.70544162
180Bone marrow hypocellularity (HP:0005528)1.70431842
181Proximal placement of thumb (HP:0009623)1.69646816
182Delusions (HP:0000746)1.67150172
183High pitched voice (HP:0001620)1.66337046
184Gastrointestinal infarctions (HP:0005244)1.64272141
185Lipid accumulation in hepatocytes (HP:0006561)1.64110310
186Aplasia/Hypoplasia involving the musculature (HP:0001460)1.63846768
187Missing ribs (HP:0000921)1.63186791
188Secondary amenorrhea (HP:0000869)1.62926400
189Cystic hygroma (HP:0000476)1.61269608

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK157.67384676
2BUB15.37701630
3NEK23.72210591
4TLK13.40676054
5CDC72.97938463
6EEF2K2.93942820
7WEE12.89631142
8WNK42.83580133
9ERN12.80785763
10SIK12.74353492
11TTK2.33944971
12SIK22.28339017
13DYRK32.15668018
14PRPF4B2.10065521
15BRSK12.04150861
16MUSK2.03062516
17MAP3K101.90157856
18SMG11.87510252
19NME21.83430056
20PLK11.82814219
21NEK11.82137280
22CHEK21.67245230
23EIF2AK11.65448040
24BRAF1.64332396
25AURKA1.57472004
26AURKB1.54135203
27TAOK11.52402010
28BRSK21.50548288
29PRKD21.48104862
30ZAP701.47658110
31IRAK21.44485648
32RIPK11.43657654
33MAP3K91.43221656
34WNK31.42582647
35TRIB31.40075076
36CDK41.39000268
37PDPK11.37755558
38MAP3K81.35805967
39MAP3K111.34913162
40KSR11.34405604
41STK161.31494972
42DYRK1B1.29005416
43TESK21.28683158
44TBK11.27586840
45WNK11.26226647
46CDK71.25565068
47CDK121.25543219
48IRAK31.25153325
49PAK41.24244331
50RPS6KA41.23178079
51BMX1.22646989
52LATS21.20762878
53DYRK21.19696120
54CDK81.15974788
55STK41.15428325
56KSR21.13780525
57VRK11.13457859
58UHMK11.12594941
59RPS6KA21.10823794
60CSK1.09185959
61CCNB11.05452593
62ICK1.03932406
63ATR1.03887221
64RAF11.03617600
65RPS6KB21.01742516
66PKN21.01532983
67TTN1.01354001
68ACVR1B0.99782076
69ARAF0.97851781
70CHEK10.95482414
71MAPK120.93250631
72CDK190.88597065
73PAK10.87152600
74TAOK20.86696806
75EPHB20.86529949
76MAPKAPK30.86316173
77RPS6KL10.86128882
78RPS6KC10.86128882
79PRKD30.83256791
80EPHA20.82470179
81SRPK10.81566058
82MKNK10.78889039
83CDK90.78364355
84STK100.78039109
85RPS6KA60.77757720
86CDC42BPA0.77590930
87PLK40.76927433
88MAP3K60.76748498
89MAP2K60.75534069
90TESK10.74900644
91MST1R0.74575416
92SIK30.74354277
93EPHB10.73306881
94PLK30.72864037
95* CDK20.71145449
96GRK60.70360183
97MAP2K30.70138241
98TYRO30.69224757
99PRKCI0.68862007
100PRKD10.67746936
101HIPK20.67497359
102RPS6KA50.66840813
103MAP3K10.66250641
104ADRBK10.66072921
105MKNK20.65177346
106PTK60.64731397
107SCYL20.64611289
108CAMKK10.64178507
109FGFR40.63817088
110PIM10.63332911
111IKBKE0.59680962
112MELK0.58679796
113ATM0.58191397
114AKT20.57678647
115MAP2K20.57591098
116RIPK40.57167368
117NME10.56327992
118PNCK0.56258137
119STK110.56188311
120PIM20.56070768
121MAPK110.55912966
122ILK0.55624560
123* CDK11A0.54507617
124CSNK1G30.54310648
125* CDK10.53198180
126* CDK150.51257012
127PASK0.50060265
128DAPK20.48659755
129MAP3K130.48651878
130CDK60.48549769
131* CDK180.48523507
132PDGFRA0.48516510
133ALK0.47503487
134NTRK10.47016634
135BLK0.45156246
136* CDK140.44782307
137MAP4K10.43592889
138STK380.43515969
139MAP3K140.42307430
140MAP3K30.42181165
141IKBKB0.40269421
142DMPK0.39809122
143MINK10.39798328
144MTOR0.38851438
145LIMK10.38434261
146LRRK20.37838689
147MAP3K40.36356027
148PDK10.35795188
149PTK20.35504950
150CSNK2A20.35042077
151MARK20.34710212
152PRKCH0.34515467
153CSNK2A10.34110359
154MOS0.33753711
155IRAK40.33708776
156RET0.31311365
157RPS6KA10.30867677
158TNK20.30793480
159* MAPK80.30623269
160MAP3K70.30264561
161SGK2230.29796356
162SGK4940.29796356
163PAK60.29104704
164SGK30.27178032
165DDR20.27032838

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006046.61845945
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.28704666
3DNA replication_Homo sapiens_hsa030304.20967459
4Ribosome_Homo sapiens_hsa030103.42577127
5Mismatch repair_Homo sapiens_hsa034303.40126735
6* Cell cycle_Homo sapiens_hsa041103.21573951
7Glycosaminoglycan degradation_Homo sapiens_hsa005313.01307310
8Fructose and mannose metabolism_Homo sapiens_hsa000512.87363774
9Spliceosome_Homo sapiens_hsa030402.85209426
10Base excision repair_Homo sapiens_hsa034102.75071685
11RNA transport_Homo sapiens_hsa030132.61882380
12RNA polymerase_Homo sapiens_hsa030202.55738038
13Homologous recombination_Homo sapiens_hsa034402.35479201
14Nucleotide excision repair_Homo sapiens_hsa034202.30755997
15Other glycan degradation_Homo sapiens_hsa005112.17087286
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.13459086
17Oocyte meiosis_Homo sapiens_hsa041142.06609563
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.03472432
19mRNA surveillance pathway_Homo sapiens_hsa030151.94422129
20Pyrimidine metabolism_Homo sapiens_hsa002401.93668072
21Fanconi anemia pathway_Homo sapiens_hsa034601.89139215
22* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.81103330
23Sphingolipid metabolism_Homo sapiens_hsa006001.80711380
24Proteasome_Homo sapiens_hsa030501.66492026
25Sulfur relay system_Homo sapiens_hsa041221.63135620
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61705474
27Systemic lupus erythematosus_Homo sapiens_hsa053221.60061535
28Basal transcription factors_Homo sapiens_hsa030221.57316454
29* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.52298782
30RNA degradation_Homo sapiens_hsa030181.50589892
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47401735
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46530412
33p53 signaling pathway_Homo sapiens_hsa041151.44550724
34Alcoholism_Homo sapiens_hsa050341.37076534
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31931558
36Vitamin B6 metabolism_Homo sapiens_hsa007501.29451599
37Inositol phosphate metabolism_Homo sapiens_hsa005621.21656515
38Circadian rhythm_Homo sapiens_hsa047101.17339832
39Lysosome_Homo sapiens_hsa041421.15531945
40Non-homologous end-joining_Homo sapiens_hsa034501.15490601
41Bladder cancer_Homo sapiens_hsa052191.14341582
42One carbon pool by folate_Homo sapiens_hsa006701.13050681
43Viral carcinogenesis_Homo sapiens_hsa052031.07212010
44Epstein-Barr virus infection_Homo sapiens_hsa051691.06805442
45Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05475031
46HTLV-I infection_Homo sapiens_hsa051661.00518548
47Thyroid cancer_Homo sapiens_hsa052160.98664369
48Chronic myeloid leukemia_Homo sapiens_hsa052200.95614899
49Colorectal cancer_Homo sapiens_hsa052100.94442472
50Non-small cell lung cancer_Homo sapiens_hsa052230.94418559
51Purine metabolism_Homo sapiens_hsa002300.92900627
52Huntingtons disease_Homo sapiens_hsa050160.92161304
53Hippo signaling pathway_Homo sapiens_hsa043900.86069935
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82138678
55MicroRNAs in cancer_Homo sapiens_hsa052060.80605875
56Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79335798
57Parkinsons disease_Homo sapiens_hsa050120.77516181
58Basal cell carcinoma_Homo sapiens_hsa052170.77202787
59Lysine degradation_Homo sapiens_hsa003100.76947503
60Hepatitis C_Homo sapiens_hsa051600.74259994
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73770247
62Notch signaling pathway_Homo sapiens_hsa043300.73520452
63Herpes simplex infection_Homo sapiens_hsa051680.72902851
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72867888
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72405474
66Glioma_Homo sapiens_hsa052140.71696399
67Hedgehog signaling pathway_Homo sapiens_hsa043400.71620495
68VEGF signaling pathway_Homo sapiens_hsa043700.71080946
69Vitamin digestion and absorption_Homo sapiens_hsa049770.70542080
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70131879
71Osteoclast differentiation_Homo sapiens_hsa043800.70014867
72Endometrial cancer_Homo sapiens_hsa052130.69094637
73Gap junction_Homo sapiens_hsa045400.68316117
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67415861
75TNF signaling pathway_Homo sapiens_hsa046680.67200686
76Taste transduction_Homo sapiens_hsa047420.66724473
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65790851
78Cocaine addiction_Homo sapiens_hsa050300.65033292
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64544247
80Insulin resistance_Homo sapiens_hsa049310.64099260
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61296639
82Hepatitis B_Homo sapiens_hsa051610.60784204
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60127170
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.59672821
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.58260012
86Acute myeloid leukemia_Homo sapiens_hsa052210.57318155
87Renal cell carcinoma_Homo sapiens_hsa052110.57048356
88Calcium signaling pathway_Homo sapiens_hsa040200.56979413
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.56957585
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56613851
91Small cell lung cancer_Homo sapiens_hsa052220.55699833
92Pancreatic cancer_Homo sapiens_hsa052120.54405624
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53365947
94Wnt signaling pathway_Homo sapiens_hsa043100.53327773
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.53289487
96Ovarian steroidogenesis_Homo sapiens_hsa049130.53142449
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51565110
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51152563
99Melanogenesis_Homo sapiens_hsa049160.50008516
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49768418
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49624875
102Shigellosis_Homo sapiens_hsa051310.48685392
103Apoptosis_Homo sapiens_hsa042100.48000101
104Cardiac muscle contraction_Homo sapiens_hsa042600.46543519
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.46154072
106Tuberculosis_Homo sapiens_hsa051520.45872673
107mTOR signaling pathway_Homo sapiens_hsa041500.45806858
108TGF-beta signaling pathway_Homo sapiens_hsa043500.45777829
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.45275771
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44256637
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.43678061
112Toxoplasmosis_Homo sapiens_hsa051450.42085095
113Prion diseases_Homo sapiens_hsa050200.41593463
114Influenza A_Homo sapiens_hsa051640.41338038
115HIF-1 signaling pathway_Homo sapiens_hsa040660.40436083
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39404222
117AMPK signaling pathway_Homo sapiens_hsa041520.39262971
118Oxidative phosphorylation_Homo sapiens_hsa001900.38462326
119Long-term depression_Homo sapiens_hsa047300.37864070
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37848063
121GnRH signaling pathway_Homo sapiens_hsa049120.37830716
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37793370
123Pathways in cancer_Homo sapiens_hsa052000.37762520
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37669227
125B cell receptor signaling pathway_Homo sapiens_hsa046620.37368266
126Long-term potentiation_Homo sapiens_hsa047200.37156192
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.36606459
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36475556
129Axon guidance_Homo sapiens_hsa043600.35875767
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35316120
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35303928
132Prolactin signaling pathway_Homo sapiens_hsa049170.34944010
133Choline metabolism in cancer_Homo sapiens_hsa052310.34875867
134N-Glycan biosynthesis_Homo sapiens_hsa005100.34759727
135T cell receptor signaling pathway_Homo sapiens_hsa046600.34723515
136Regulation of autophagy_Homo sapiens_hsa041400.34346979
137Estrogen signaling pathway_Homo sapiens_hsa049150.33688555
138Prostate cancer_Homo sapiens_hsa052150.33455033
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33169888
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32484008
141ErbB signaling pathway_Homo sapiens_hsa040120.32289196
142Insulin signaling pathway_Homo sapiens_hsa049100.31927221
143Chemokine signaling pathway_Homo sapiens_hsa040620.31312631
144Leukocyte transendothelial migration_Homo sapiens_hsa046700.31292312
145Cholinergic synapse_Homo sapiens_hsa047250.30547809
146Jak-STAT signaling pathway_Homo sapiens_hsa046300.29743689
147Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29395623
148Dopaminergic synapse_Homo sapiens_hsa047280.29080038
149Melanoma_Homo sapiens_hsa052180.28741352
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28585311
151FoxO signaling pathway_Homo sapiens_hsa040680.28509286
152Pertussis_Homo sapiens_hsa051330.28180613
153Dorso-ventral axis formation_Homo sapiens_hsa043200.27669820
154Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27668939
155Endocytosis_Homo sapiens_hsa041440.27370761
156MAPK signaling pathway_Homo sapiens_hsa040100.25819385

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