G0S2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alpha-linolenic acid metabolic process (GO:0036109)6.10060195
2triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.80214070
3regulation of sequestering of triglyceride (GO:0010889)5.67206255
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.52770351
5L-phenylalanine catabolic process (GO:0006559)5.52770351
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.39199820
7L-phenylalanine metabolic process (GO:0006558)5.39199820
8regulation of triglyceride catabolic process (GO:0010896)5.24617023
9positive regulation of fatty acid beta-oxidation (GO:0032000)4.95238832
10valine metabolic process (GO:0006573)4.77936796
11fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.75687944
12aromatic amino acid family catabolic process (GO:0009074)4.72699150
13fatty acid transmembrane transport (GO:1902001)4.71526226
14fatty acid beta-oxidation (GO:0006635)4.67798128
15positive regulation of fatty acid oxidation (GO:0046321)4.64640306
16plasma lipoprotein particle clearance (GO:0034381)4.61878071
17biotin metabolic process (GO:0006768)4.61049522
18sulfur amino acid catabolic process (GO:0000098)4.60161076
19acetyl-CoA metabolic process (GO:0006084)4.51760345
20glyoxylate metabolic process (GO:0046487)4.49440188
21positive regulation of lipid catabolic process (GO:0050996)4.48028842
22low-density lipoprotein particle clearance (GO:0034383)4.47289795
23lysine metabolic process (GO:0006553)4.46695907
24lysine catabolic process (GO:0006554)4.46695907
25complement activation, alternative pathway (GO:0006957)4.40163909
26fatty acid oxidation (GO:0019395)4.39671646
27carnitine shuttle (GO:0006853)4.36299224
28acylglycerol homeostasis (GO:0055090)4.33958132
29triglyceride homeostasis (GO:0070328)4.33958132
30lipid oxidation (GO:0034440)4.32450276
31high-density lipoprotein particle remodeling (GO:0034375)4.32320457
32bile acid biosynthetic process (GO:0006699)4.30355761
33fatty acid catabolic process (GO:0009062)4.29607608
34triglyceride catabolic process (GO:0019433)4.29581231
35amino-acid betaine metabolic process (GO:0006577)4.25906486
36cysteine metabolic process (GO:0006534)4.21661279
37lipid storage (GO:0019915)4.19819836
38neutral lipid catabolic process (GO:0046461)4.18774690
39acylglycerol catabolic process (GO:0046464)4.18774690
40urea metabolic process (GO:0019627)4.18259190
41urea cycle (GO:0000050)4.18259190
42short-chain fatty acid metabolic process (GO:0046459)4.17501223
43branched-chain amino acid catabolic process (GO:0009083)4.15779197
44kynurenine metabolic process (GO:0070189)4.10879847
45regulation of fatty acid beta-oxidation (GO:0031998)4.09137385
46positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.07940733
47plasma lipoprotein particle remodeling (GO:0034369)4.04368981
48protein-lipid complex remodeling (GO:0034368)4.04368981
49macromolecular complex remodeling (GO:0034367)4.04368981
50indole-containing compound catabolic process (GO:0042436)4.02275952
51indolalkylamine catabolic process (GO:0046218)4.02275952
52tryptophan catabolic process (GO:0006569)4.02275952
53cellular ketone body metabolic process (GO:0046950)4.01277469
54negative regulation of fibrinolysis (GO:0051918)4.00726655
55regulation of fatty acid oxidation (GO:0046320)3.99937805
562-oxoglutarate metabolic process (GO:0006103)3.98377058
57branched-chain amino acid metabolic process (GO:0009081)3.98152165
58monocarboxylic acid catabolic process (GO:0072329)3.98078870
59protein carboxylation (GO:0018214)3.96481968
60peptidyl-glutamic acid carboxylation (GO:0017187)3.96481968
61regulation of cholesterol esterification (GO:0010872)3.93778360
62reverse cholesterol transport (GO:0043691)3.90412463
63positive regulation of heat generation (GO:0031652)3.89989833
64nitrogen cycle metabolic process (GO:0071941)3.87142729
65serine family amino acid catabolic process (GO:0009071)3.85572446
66regulation of vitamin D biosynthetic process (GO:0060556)3.84189318
67regulation of protein activation cascade (GO:2000257)3.82921658
68acyl-CoA biosynthetic process (GO:0071616)3.81991089
69thioester biosynthetic process (GO:0035384)3.81991089
70tryptophan metabolic process (GO:0006568)3.81521512
71response to peptidoglycan (GO:0032494)3.78390689
72negative regulation of lipase activity (GO:0060192)3.77341617
73regulation of fibrinolysis (GO:0051917)3.77069059
74ethanol oxidation (GO:0006069)3.76702651
75carnitine metabolic process (GO:0009437)3.76403261
76positive regulation of triglyceride metabolic process (GO:0090208)3.75811271
77negative regulation of lipid storage (GO:0010888)3.74466905
78bile acid metabolic process (GO:0008206)3.73974825
79positive regulation of lipid storage (GO:0010884)3.71266985
80regulation of membrane protein ectodomain proteolysis (GO:0051043)3.70596944
81phospholipid efflux (GO:0033700)3.70178145
82regulation of triglyceride metabolic process (GO:0090207)3.69282035
83alpha-amino acid catabolic process (GO:1901606)3.68495894
84phospholipid homeostasis (GO:0055091)3.66807576
85regulation of fever generation (GO:0031620)3.65100055
86homocysteine metabolic process (GO:0050667)3.63896453
87fatty-acyl-CoA biosynthetic process (GO:0046949)3.63410802
88regulation of complement activation (GO:0030449)3.60031468
89brown fat cell differentiation (GO:0050873)3.59772590
90positive regulation of fatty acid metabolic process (GO:0045923)3.59215816
91linoleic acid metabolic process (GO:0043651)3.58067712
92positive regulation of lipoprotein lipase activity (GO:0051006)3.58014729
93positive regulation of triglyceride lipase activity (GO:0061365)3.58014729
94tyrosine metabolic process (GO:0006570)3.56850461
95organic acid catabolic process (GO:0016054)3.56549058
96carboxylic acid catabolic process (GO:0046395)3.56549058
97cellular amino acid catabolic process (GO:0009063)3.55143430
98fatty acid homeostasis (GO:0055089)3.50685275
99carnitine transmembrane transport (GO:1902603)3.48124557
100ketone body metabolic process (GO:1902224)3.44219697
101thioester metabolic process (GO:0035383)3.43894621
102acyl-CoA metabolic process (GO:0006637)3.43894621
103triglyceride metabolic process (GO:0006641)3.41955475
104aromatic amino acid family metabolic process (GO:0009072)3.40499517
105positive regulation of cholesterol efflux (GO:0010875)3.39314791
106regulation of cholesterol storage (GO:0010885)3.39173857
107negative regulation of fatty acid biosynthetic process (GO:0045717)3.38915760
108coenzyme catabolic process (GO:0009109)3.37945352
109negative regulation of cholesterol transport (GO:0032375)3.37611185
110negative regulation of sterol transport (GO:0032372)3.37611185
111negative regulation of nitric oxide biosynthetic process (GO:0045019)3.37512709
112regulation of cholesterol metabolic process (GO:0090181)3.36050021
113amino-acid betaine transport (GO:0015838)3.35953212
114regulation of vitamin metabolic process (GO:0030656)3.35470145
115negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.33086095
116lipopolysaccharide-mediated signaling pathway (GO:0031663)3.32843863
117negative regulation of interleukin-12 production (GO:0032695)3.24287931
118regulation of lipid storage (GO:0010883)3.22537610
119regulation of heterotypic cell-cell adhesion (GO:0034114)3.18637173
120negative regulation of tumor necrosis factor production (GO:0032720)3.05734067
121germinal center formation (GO:0002467)3.04630274
122diacylglycerol metabolic process (GO:0046339)3.03380979
123NADH metabolic process (GO:0006734)2.99225318
124T-helper 1 type immune response (GO:0042088)2.99147868
125negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.97036556
126negative regulation of amino acid transport (GO:0051956)2.96183773
127transcytosis (GO:0045056)2.94484604
128regulation of mononuclear cell migration (GO:0071675)2.85450567
129regulation of heat generation (GO:0031650)2.83439999
130positive regulation of cholesterol transport (GO:0032376)2.82414005
131positive regulation of sterol transport (GO:0032373)2.82414005
132glycerolipid catabolic process (GO:0046503)2.81527897
133triglyceride biosynthetic process (GO:0019432)2.81474868
134positive regulation of chemokine biosynthetic process (GO:0045080)2.79453893
135negative regulation of granulocyte differentiation (GO:0030853)2.78800250
136positive regulation of acute inflammatory response (GO:0002675)2.78624687
137barbed-end actin filament capping (GO:0051016)2.78381560
138cellular response to epinephrine stimulus (GO:0071872)2.75644097
139negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.74565439
140detection of molecule of bacterial origin (GO:0032490)2.74475390
141neutrophil activation involved in immune response (GO:0002283)2.72009154
142positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.71831571
143regulation of macrophage derived foam cell differentiation (GO:0010743)2.71301175
144negative regulation of smooth muscle cell migration (GO:0014912)2.67468839
145macrophage activation involved in immune response (GO:0002281)2.65779834
146neutral lipid biosynthetic process (GO:0046460)2.64370453
147acylglycerol biosynthetic process (GO:0046463)2.64370453
148regulation of nitric oxide biosynthetic process (GO:0045428)2.63674630
149regulation of T-helper 1 cell differentiation (GO:0045625)2.61835860
150positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.61251190
151NIK/NF-kappaB signaling (GO:0038061)2.59682121
152positive regulation of NF-kappaB import into nucleus (GO:0042346)2.59280334
153positive regulation of fatty acid biosynthetic process (GO:0045723)2.57349507
154regulation of chemokine biosynthetic process (GO:0045073)2.56683428
155negative regulation of smooth muscle cell proliferation (GO:0048662)2.54300113
156response to muramyl dipeptide (GO:0032495)2.52867102
157lymphocyte chemotaxis (GO:0048247)2.51754663
158regulation of chronic inflammatory response (GO:0002676)2.50628045
159regulation of cytokine secretion involved in immune response (GO:0002739)2.49966430
160response to progesterone (GO:0032570)2.48981581
161cellular response to lipopolysaccharide (GO:0071222)2.48496950
162ovulation from ovarian follicle (GO:0001542)2.47410886
163cellular response to type I interferon (GO:0071357)2.47183671
164type I interferon signaling pathway (GO:0060337)2.47183671
165negative regulation of erythrocyte differentiation (GO:0045647)2.46451629
166negative regulation of cytokine production involved in immune response (GO:0002719)2.46422723
167negative regulation of lipid catabolic process (GO:0050995)2.45269399
168regulation of podosome assembly (GO:0071801)2.45191254
169regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.45141825
170ovulation (GO:0030728)2.44252093
171virion attachment to host cell (GO:0019062)2.44015837
172adhesion of symbiont to host cell (GO:0044650)2.44015837
173regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.42759452
174response to type I interferon (GO:0034340)2.42438214
175negative regulation of protein autophosphorylation (GO:0031953)2.42218701
176regulation of myeloid cell apoptotic process (GO:0033032)2.41720766
177cellular response to arsenic-containing substance (GO:0071243)2.41422864
178cellular response to molecule of bacterial origin (GO:0071219)2.41084507
179oxaloacetate metabolic process (GO:0006107)2.39823699
180regulation of necrotic cell death (GO:0010939)2.38324994
181positive regulation of nitric oxide biosynthetic process (GO:0045429)2.37815637
182regulation of tumor necrosis factor production (GO:0032680)2.37379817
183regulation of T-helper 2 cell differentiation (GO:0045628)2.37373627
184tyrosine phosphorylation of STAT protein (GO:0007260)2.34715535
185positive regulation of fat cell differentiation (GO:0045600)2.34225958
186cellular extravasation (GO:0045123)2.33768445
187regulation of gonadotropin secretion (GO:0032276)2.33453154
188defense response to protozoan (GO:0042832)2.32834240
189response to manganese ion (GO:0010042)2.32826162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.53604617
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.32249291
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.85652265
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.94389685
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.51595643
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.78231748
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.44876046
8* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.20345033
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.92313998
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.82414099
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.63894607
12* CLOCK_20551151_ChIP-Seq_293T_Human2.97516408
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.68475161
14* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40771783
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36566426
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.35945481
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.27275548
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.17806889
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.07112135
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.06655650
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94253764
22VDR_24763502_ChIP-Seq_THP-1_Human1.88296886
23VDR_21846776_ChIP-Seq_THP-1_Human1.85641767
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82090388
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81295611
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79604601
27TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.77758924
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72437759
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.72349411
30* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.71849111
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67575079
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66811805
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56301290
34GATA1_22025678_ChIP-Seq_K562_Human1.53268689
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.51550962
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51219816
37VDR_24787735_ChIP-Seq_THP-1_Human1.47952887
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46189823
39RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43683428
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43408749
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42104622
42FOXA2_19822575_ChIP-Seq_HepG2_Human1.40509198
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39032148
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36927439
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35586648
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.34583090
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.33269956
48SPI1_23127762_ChIP-Seq_K562_Human1.30771432
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.29717935
50ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28712016
51ZNF263_19887448_ChIP-Seq_K562_Human1.27286089
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26810945
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21072478
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.19311561
55JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18443228
56TCF7_22412390_ChIP-Seq_EML_Mouse1.17609086
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17557917
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.16238900
59MAF_26560356_Chip-Seq_TH1_Human1.15659341
60KDM2B_26808549_Chip-Seq_DND41_Human1.14338339
61* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13925420
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13887181
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13461702
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12343561
65* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11847933
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11578906
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11503384
68HNF4A_19822575_ChIP-Seq_HepG2_Human1.11175395
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10855614
70JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10168112
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09820337
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08632365
73* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.07648690
74RUNX_20019798_ChIP-Seq_JUKART_Human1.07403007
75* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06476133
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06326396
77* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05644367
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04648062
79TBX20_22328084_ChIP-Seq_HEART_Mouse1.03841306
80TBX20_22080862_ChIP-Seq_HEART_Mouse1.03841306
81PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03681213
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02674185
83* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02641955
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01581204
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00579683
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00490677
87SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00374703
88ESR1_21235772_ChIP-Seq_MCF-7_Human0.98388586
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97631495
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97478081
91GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97291797
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97190370
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97190370
94SPI1_23547873_ChIP-Seq_NB4_Human0.96348811
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96029293
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.96023825
97ATF3_27146783_Chip-Seq_COLON_Human0.95131509
98SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94867718
99STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94811756
100PU_27001747_Chip-Seq_BMDM_Mouse0.94594301
101* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93866673
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90985052
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88864844
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87740881
105NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87740881
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87449541
107TP63_17297297_ChIP-ChIP_HaCaT_Human0.87149967
108EP300_21415370_ChIP-Seq_HL-1_Mouse0.86986261
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86647443
110HTT_18923047_ChIP-ChIP_STHdh_Human0.85222167
111GATA4_25053715_ChIP-Seq_YYC3_Human0.81700448
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80120377
113* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.79703045
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.77490374
115ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76950921
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76928827
117AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76602241
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76350517
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.75304559
120CDX2_19796622_ChIP-Seq_MESCs_Mouse0.75141757
121* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.74532555
122IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.73470731
123LXR_22292898_ChIP-Seq_THP-1_Human0.70100097
124GATA1_19941826_ChIP-Seq_K562_Human0.69372202
125RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64803719
126* CEBPB_22108803_ChIP-Seq_LS180_Human0.63973486
127GATA2_19941826_ChIP-Seq_K562_Human0.62800852
128HIF1A_21447827_ChIP-Seq_MCF-7_Human0.62253498
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.62014443
130GATA2_21666600_ChIP-Seq_HMVEC_Human0.60190821
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.59501505
132GATA3_24758297_ChIP-Seq_MCF-7_Human0.59113982
133RACK7_27058665_Chip-Seq_MCF-7_Human0.58797351
134STAT3_1855785_ChIP-Seq_MESCs_Mouse0.58587932
135* SOX2_20726797_ChIP-Seq_SW620_Human0.57798238
136SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.57722256
137IRF8_22096565_ChIP-ChIP_GC-B_Human0.57473651
138BCAT_22108803_ChIP-Seq_LS180_Human0.56860082
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.56753831
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.56701221
141BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.54829653
142FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.54387405
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.54175263
144FOXA1_25552417_ChIP-Seq_VCAP_Human0.52931028
145CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.52256687
146CJUN_26792858_Chip-Seq_BT549_Human0.51886528
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.51661629
148P63_26484246_Chip-Seq_KERATINOCYTES_Human0.51320313
149RARA_24833708_ChIP-Seq_LIVER_Mouse0.50684805
150NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.50390234
151KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.49567899
152CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.47325656
153CBP_21632823_ChIP-Seq_H3396_Human0.47284246
154SOX9_24532713_ChIP-Seq_HFSC_Mouse0.46991158
155PIAS1_25552417_ChIP-Seq_VCAP_Human0.46260655
156CDX2_20551321_ChIP-Seq_CACO-2_Human0.46081209
157SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.44956895
158AR_20517297_ChIP-Seq_VCAP_Human0.44774451
159* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.43718855
160SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43682865
161EGR1_19032775_ChIP-ChIP_M12_Human0.43532562

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.50832943
2MP0005360_urolithiasis5.62817279
3MP0005365_abnormal_bile_salt5.03701230
4MP0005085_abnormal_gallbladder_physiolo4.81142858
5MP0003303_peritoneal_inflammation4.23273433
6MP0005670_abnormal_white_adipose3.95218222
7MP0010329_abnormal_lipoprotein_level3.74334066
8MP0008875_abnormal_xenobiotic_pharmacok3.68511745
9MP0003806_abnormal_nucleotide_metabolis3.18414287
10MP0004130_abnormal_muscle_cell3.11226127
11MP0004510_myositis2.93421808
12MP0003252_abnormal_bile_duct2.74840700
13MP0003436_decreased_susceptibility_to2.70315136
14MP0005666_abnormal_adipose_tissue2.66578780
15MP0002837_dystrophic_cardiac_calcinosis2.61132550
16MP0009840_abnormal_foam_cell2.60021168
17MP0005332_abnormal_amino_acid2.57780587
18MP0003191_abnormal_cellular_cholesterol2.44340516
19MP0002118_abnormal_lipid_homeostasis2.43521422
20MP0005083_abnormal_biliary_tract2.33087425
21MP0003075_altered_response_to2.22042930
22MP0005058_abnormal_lysosome_morphology2.20223903
23MP0009785_altered_susceptibility_to2.18498216
24MP0002148_abnormal_hypersensitivity_rea2.17496830
25MP0000609_abnormal_liver_physiology2.11065521
26MP0004185_abnormal_adipocyte_glucose2.10247277
27MP0002971_abnormal_brown_adipose1.94570825
28MP0001666_abnormal_nutrient_absorption1.91787295
29MP0001533_abnormal_skeleton_physiology1.91707864
30MP0003828_pulmonary_edema1.90083960
31MP0003195_calcinosis1.88824831
32MP0001881_abnormal_mammary_gland1.88706523
33MP0008004_abnormal_stomach_pH1.82486088
34MP0002419_abnormal_innate_immunity1.81929888
35MP0008438_abnormal_cutaneous_collagen1.78043406
36MP0006082_CNS_inflammation1.77865383
37MP0004019_abnormal_vitamin_homeostasis1.77469455
38MP0005319_abnormal_enzyme/_coenzyme1.76611141
39MP0005375_adipose_tissue_phenotype1.74151528
40MP0003705_abnormal_hypodermis_morpholog1.70754918
41MP0005000_abnormal_immune_tolerance1.64216682
42MP0005584_abnormal_enzyme/coenzyme_acti1.61477276
43MP0005025_abnormal_response_to1.60152216
44MP0005167_abnormal_blood-brain_barrier1.58089756
45MP0009278_abnormal_bone_marrow1.57713832
46MP0003300_gastrointestinal_ulcer1.57343563
47MP0003186_abnormal_redox_activity1.56496130
48MP0001764_abnormal_homeostasis1.54133389
49MP0004947_skin_inflammation1.53057818
50MP0000858_altered_metastatic_potential1.50635796
51MP0005334_abnormal_fat_pad1.47963229
52MP0000750_abnormal_muscle_regeneration1.46303479
53MP0003011_delayed_dark_adaptation1.45891182
54MP0001835_abnormal_antigen_presentation1.44195071
55MP0005387_immune_system_phenotype1.41058295
56MP0001790_abnormal_immune_system1.41058295
57MP0003453_abnormal_keratinocyte_physiol1.39415435
58MP0006036_abnormal_mitochondrial_physio1.38152302
59MP0005166_decreased_susceptibility_to1.35055975
60MP0001545_abnormal_hematopoietic_system1.34331190
61MP0005397_hematopoietic_system_phenotyp1.34331190
62MP0009115_abnormal_fat_cell1.26245528
63MP0005535_abnormal_body_temperature1.25787084
64MP0003950_abnormal_plasma_membrane1.25762966
65MP0009643_abnormal_urine_homeostasis1.24894814
66MP0002254_reproductive_system_inflammat1.24394685
67MP0002876_abnormal_thyroid_physiology1.24346551
68MP0002998_abnormal_bone_remodeling1.24148746
69MP0005451_abnormal_body_composition1.22521829
70MP0003448_altered_tumor_morphology1.20713159
71MP0003646_muscle_fatigue1.19678635
72MP0005165_increased_susceptibility_to1.18786052
73MP0002452_abnormal_antigen_presenting1.17689041
74MP0002723_abnormal_immune_serum1.17199285
75MP0001661_extended_life_span1.15240998
76MP0002078_abnormal_glucose_homeostasis1.13619703
77MP0001845_abnormal_inflammatory_respons1.12856605
78MP0002138_abnormal_hepatobiliary_system1.08369117
79MP0002970_abnormal_white_adipose1.07448709
80MP0005275_abnormal_skin_tensile1.03470888
81MP0001542_abnormal_bone_strength1.01698583
82MP0001800_abnormal_humoral_immune1.00934718
83MP0005464_abnormal_platelet_physiology0.99869757
84MP0005330_cardiomyopathy0.99740911
85MP0010368_abnormal_lymphatic_system0.99608966
86MP0000598_abnormal_liver_morphology0.98468944
87MP0005448_abnormal_energy_balance0.97661423
88MP0000003_abnormal_adipose_tissue0.97157595
89MP0003690_abnormal_glial_cell0.96994175
90MP0005023_abnormal_wound_healing0.95444315
91MP0003656_abnormal_erythrocyte_physiolo0.95315855
92MP0010155_abnormal_intestine_physiology0.95205163
93MP0001819_abnormal_immune_cell0.95141864
94MP0002420_abnormal_adaptive_immunity0.95021827
95MP0002933_joint_inflammation0.94798195
96MP0005647_abnormal_sex_gland0.94299185
97MP0000013_abnormal_adipose_tissue0.93275491
98MP0000685_abnormal_immune_system0.93187911
99MP0003724_increased_susceptibility_to0.91583559
100MP0005390_skeleton_phenotype0.91432247
101MP0003091_abnormal_cell_migration0.91363145
102MP0009763_increased_sensitivity_to0.90422562
103MP0002405_respiratory_system_inflammati0.89991503
104MP0000759_abnormal_skeletal_muscle0.89549790
105MP0003868_abnormal_feces_composition0.89109216
106MP0009697_abnormal_copulation0.88338040
107MP0008260_abnormal_autophagy0.85388218
108MP0005376_homeostasis/metabolism_phenot0.84650053
109MP0003279_aneurysm0.84492785
110MP0006138_congestive_heart_failure0.83230149
111MP0005385_cardiovascular_system_phenoty0.81969440
112MP0001544_abnormal_cardiovascular_syste0.81969440
113MP0002332_abnormal_exercise_endurance0.81279152
114MP0008775_abnormal_heart_ventricle0.80142717
115MP0001727_abnormal_embryo_implantation0.80043364
116MP0009642_abnormal_blood_homeostasis0.78275977
117MP0009764_decreased_sensitivity_to0.77621877
118MP0000604_amyloidosis0.76456933
119MP0000747_muscle_weakness0.76195081
120MP0005266_abnormal_metabolism0.75517103
121MP0003959_abnormal_lean_body0.75477420
122MP0001756_abnormal_urination0.74466355
123MP0005636_abnormal_mineral_homeostasis0.72211436
124MP0004272_abnormal_basement_membrane0.71398085
125MP0004087_abnormal_muscle_fiber0.71113771
126MP0004215_abnormal_myocardial_fiber0.70469252
127MP0000751_myopathy0.69975414
128MP0002972_abnormal_cardiac_muscle0.69656257
129MP0004147_increased_porphyrin_level0.67403967
130MP0000230_abnormal_systemic_arterial0.67334182
131MP0004036_abnormal_muscle_relaxation0.67289374
132MP0005620_abnormal_muscle_contractility0.67127814
133MP0008469_abnormal_protein_level0.66702593
134MP0005452_abnormal_adipose_tissue0.65240317
135MP0002796_impaired_skin_barrier0.63748526
136MP0000749_muscle_degeneration0.61266596
137MP0000343_altered_response_to0.61246868
138MP0002060_abnormal_skin_morphology0.60891501
139MP0003221_abnormal_cardiomyocyte_apopto0.60252387
140MP0002269_muscular_atrophy0.59932007
141MP0004084_abnormal_cardiac_muscle0.58848478
142MP0005164_abnormal_response_to0.58268204
143MP0010630_abnormal_cardiac_muscle0.56960208
144MP0003953_abnormal_hormone_level0.56591864
145MP0006035_abnormal_mitochondrial_morpho0.51500649
146MP0000249_abnormal_blood_vessel0.50966311
147MP0002168_other_aberrant_phenotype0.50712614
148MP0001853_heart_inflammation0.50058104
149MP0009384_cardiac_valve_regurgitation0.49763888
150MP0005595_abnormal_vascular_smooth0.49098472
151MP0004883_abnormal_blood_vessel0.47205072

Predicted human phenotypes

RankGene SetZ-score
1Xanthomatosis (HP:0000991)5.60265174
2Deep venous thrombosis (HP:0002625)5.53080142
3Hyperlipoproteinemia (HP:0010980)5.24123949
4Hyperglycinuria (HP:0003108)5.17288128
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.15050668
6Intrahepatic cholestasis (HP:0001406)4.86814468
7Hypoglycemic coma (HP:0001325)4.77903822
8Ketosis (HP:0001946)4.71145954
9Abnormality of serine family amino acid metabolism (HP:0010894)4.71114977
10Abnormality of glycine metabolism (HP:0010895)4.71114977
11Hyperammonemia (HP:0001987)4.65140753
12Complement deficiency (HP:0004431)4.45473339
13Hypobetalipoproteinemia (HP:0003563)4.42075855
14Abnormality of fatty-acid metabolism (HP:0004359)4.40898723
15Hypoalphalipoproteinemia (HP:0003233)4.37444705
16Prolonged partial thromboplastin time (HP:0003645)4.36694071
17Hyperglycinemia (HP:0002154)4.36533853
18Abnormality of monocarboxylic acid metabolism (HP:0010996)4.35060230
19Abnormality of glycolipid metabolism (HP:0010969)4.34681045
20Abnormality of liposaccharide metabolism (HP:0010968)4.34681045
21Abnormality of glycosphingolipid metabolism (HP:0004343)4.34681045
22Epidermoid cyst (HP:0200040)4.18766782
23Hypolipoproteinemia (HP:0010981)4.13219512
24Ketoacidosis (HP:0001993)4.12401090
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.09807290
26Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.90641481
27Orchitis (HP:0100796)3.72592637
28Axonal loss (HP:0003447)3.62534535
29Abnormality of dicarboxylic acid metabolism (HP:0010995)3.60808665
30Dicarboxylic aciduria (HP:0003215)3.60808665
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.48246714
32Myoglobinuria (HP:0002913)3.39906518
33Myositis (HP:0100614)3.35921776
34Hypercholesterolemia (HP:0003124)3.32669005
35Optic neuritis (HP:0100653)3.32131572
36Retrobulbar optic neuritis (HP:0100654)3.32131572
37Abnormality of macrophages (HP:0004311)3.30784838
38Abnormality of the common coagulation pathway (HP:0010990)3.26081169
39Joint hemorrhage (HP:0005261)3.21707945
40Abnormality of aspartate family amino acid metabolism (HP:0010899)3.16051672
41Abnormality of complement system (HP:0005339)3.13312870
42Dysostosis multiplex (HP:0000943)3.12947358
43Hypertriglyceridemia (HP:0002155)3.10550517
44Abnormality of purine metabolism (HP:0004352)3.07464459
45Asymmetric septal hypertrophy (HP:0001670)3.03497221
46Generalized aminoaciduria (HP:0002909)3.02611602
47Abnormality of sulfur amino acid metabolism (HP:0004339)3.01427945
48Abnormality of serum amino acid levels (HP:0003112)2.99991720
49Abnormality of methionine metabolism (HP:0010901)2.95065456
50Lethargy (HP:0001254)2.94864406
51Muscle fiber splitting (HP:0003555)2.94503384
52Skin nodule (HP:0200036)2.93985865
53Cerebral edema (HP:0002181)2.93175006
54Metabolic acidosis (HP:0001942)2.87571246
55Abnormality of the intrinsic pathway (HP:0010989)2.87076204
56Nausea (HP:0002018)2.83197161
57Difficulty running (HP:0009046)2.82512966
58Stomatitis (HP:0010280)2.81574820
59Oligomenorrhea (HP:0000876)2.81021293
60Myocardial infarction (HP:0001658)2.80366506
61Rhabdomyolysis (HP:0003201)2.79607905
62Increased variability in muscle fiber diameter (HP:0003557)2.78513928
63Elevated erythrocyte sedimentation rate (HP:0003565)2.76907296
64Vertebral compression fractures (HP:0002953)2.75449028
65Abnormality of skeletal muscle fiber size (HP:0012084)2.74532864
66Abnormality of nucleobase metabolism (HP:0010932)2.74344259
67Nuclear cataract (HP:0100018)2.73247586
68Increased connective tissue (HP:0009025)2.71222846
69Fat malabsorption (HP:0002630)2.66127576
70Keratoconjunctivitis sicca (HP:0001097)2.65334025
71Recurrent bacterial skin infections (HP:0005406)2.61053547
72Eczematoid dermatitis (HP:0000976)2.60490265
73Hydroxyprolinuria (HP:0003080)2.59995191
74Abnormality of proline metabolism (HP:0010907)2.59995191
75Muscle fiber inclusion bodies (HP:0100299)2.59007600
76Nemaline bodies (HP:0003798)2.57430443
77Vacuolated lymphocytes (HP:0001922)2.56127661
78Loss of speech (HP:0002371)2.54543226
79Hepatosplenomegaly (HP:0001433)2.53466702
80Acanthosis nigricans (HP:0000956)2.53070615
81Vomiting (HP:0002013)2.50308101
82Neurofibrillary tangles (HP:0002185)2.49840881
83Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.48957184
84Recurrent abscess formation (HP:0002722)2.48777283
85Delayed CNS myelination (HP:0002188)2.46426948
86Hyperbilirubinemia (HP:0002904)2.44841792
87Pancreatitis (HP:0001733)2.44717995
88Abnormality of polysaccharide metabolism (HP:0011012)2.43105005
89Abnormality of glycosaminoglycan metabolism (HP:0004371)2.43105005
90Abnormality of mucopolysaccharide metabolism (HP:0011020)2.43105005
91Mutism (HP:0002300)2.39778304
92Mediastinal lymphadenopathy (HP:0100721)2.38188837
93Hepatic necrosis (HP:0002605)2.37741225
94Increased serum ferritin (HP:0003281)2.37459885
95Increased muscle lipid content (HP:0009058)2.36947654
96Hypoglycemic seizures (HP:0002173)2.35334706
97Gout (HP:0001997)2.35062039
98Distal lower limb muscle weakness (HP:0009053)2.34796761
99Renal cortical cysts (HP:0000803)2.33906998
100Keratoconjunctivitis (HP:0001096)2.32812589
101Reduced subcutaneous adipose tissue (HP:0003758)2.30682439
102Hepatocellular carcinoma (HP:0001402)2.29995268
103Proximal tubulopathy (HP:0000114)2.29156106
104Neck muscle weakness (HP:0000467)2.28683178
105Hemorrhage of the eye (HP:0011885)2.28291140
106Abnormal cartilage morphology (HP:0002763)2.23916448
107Bone cyst (HP:0012062)2.23649499
108Glomerulonephritis (HP:0000099)2.23466492
109Amyloidosis (HP:0011034)2.22750715
110Mucopolysacchariduria (HP:0008155)2.22317974
111Urinary glycosaminoglycan excretion (HP:0003541)2.22317974
112Type 1 muscle fiber predominance (HP:0003803)2.20910071
113Systemic lupus erythematosus (HP:0002725)2.20150727
114Recurrent gram-negative bacterial infections (HP:0005420)2.17705080
115Brushfield spots (HP:0001088)2.16701575
116Cholelithiasis (HP:0001081)2.14857387
117Cerebral inclusion bodies (HP:0100314)2.14689305
118Hyperglycemia (HP:0003074)2.14393429
119Increased cerebral lipofuscin (HP:0011813)2.10483636
120Insulin-resistant diabetes mellitus (HP:0000831)2.10453862
121Abnormal gallbladder morphology (HP:0012437)2.09614090
122Interstitial pulmonary disease (HP:0006530)2.08303186
123Polycythemia (HP:0001901)2.08148905
124Abnormality of pyrimidine metabolism (HP:0004353)2.08103858
125Right ventricular cardiomyopathy (HP:0011663)2.06477409
126Colitis (HP:0002583)2.06159989
127Hyperinsulinemic hypoglycemia (HP:0000825)2.05049180
128Hyperuricemia (HP:0002149)2.03632280
129Increased purine levels (HP:0004368)2.03632280
130Distal lower limb amyotrophy (HP:0008944)2.03350845
131Polygenic inheritance (HP:0010982)2.02849018
132Frequent falls (HP:0002359)2.00586200
133EMG: myopathic abnormalities (HP:0003458)2.00344744
134Vascular calcification (HP:0004934)1.99535340
135Bulbar palsy (HP:0001283)1.99110414
136Enlarged kidneys (HP:0000105)1.97910746
137Gastrointestinal infarctions (HP:0005244)1.97116523
138Fatigue (HP:0012378)1.96729446
139Increased serum pyruvate (HP:0003542)1.95881445
140Abnormality of glycolysis (HP:0004366)1.95881445
141Vasculitis (HP:0002633)1.95680104
142Acute encephalopathy (HP:0006846)1.95590159
143Steatorrhea (HP:0002570)1.95471245
144Hyporeflexia of lower limbs (HP:0002600)1.94572077
145Muscle stiffness (HP:0003552)1.93176212
146Conjugated hyperbilirubinemia (HP:0002908)1.91866652
147Centrally nucleated skeletal muscle fibers (HP:0003687)1.91134608
148Gangrene (HP:0100758)1.90290349
149Exercise-induced myalgia (HP:0003738)1.89601910
150Disinhibition (HP:0000734)1.89490073
151Irritability (HP:0000737)1.89442114
152Cardiovascular calcification (HP:0011915)1.89420272
153Spontaneous abortion (HP:0005268)1.88570238
154Progressive neurologic deterioration (HP:0002344)1.87859982
155Cholecystitis (HP:0001082)1.87685653
156Abnormal gallbladder physiology (HP:0012438)1.87685653
157Pulmonary infiltrates (HP:0002113)1.87479267
158Sensorimotor neuropathy (HP:0007141)1.86398425
159Late onset (HP:0003584)1.85163481
160Glomerulopathy (HP:0100820)1.85089603
161Methylmalonic aciduria (HP:0012120)1.84813233
162Spastic diplegia (HP:0001264)1.84196818
163Insulin resistance (HP:0000855)1.83739220
164Purpura (HP:0000979)1.83507801
165Increased IgM level (HP:0003496)1.82674634
166Spinal rigidity (HP:0003306)1.81164766
167Esophageal varix (HP:0002040)1.81019889
168Elevated hepatic transaminases (HP:0002910)1.80079397
169Protrusio acetabuli (HP:0003179)1.79481293
170Mitral stenosis (HP:0001718)1.78638548
171Lipoatrophy (HP:0100578)1.78538198
172Episodic fever (HP:0001954)1.78511494
173Glycosuria (HP:0003076)1.78316020
174Abnormality of urine glucose concentration (HP:0011016)1.78316020
175Respiratory distress (HP:0002098)1.78168358
176Abnormality of iron homeostasis (HP:0011031)1.77178401
177Autoimmune thrombocytopenia (HP:0001973)1.75984591
178Hemoptysis (HP:0002105)1.74737450
179Gingivitis (HP:0000230)1.70209407
180Difficulty climbing stairs (HP:0003551)1.69272422
181Arterial thrombosis (HP:0004420)1.68686062

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.52124328
2SIK15.14559213
3TRIB34.23598495
4CAMK1D3.51032425
5ERN13.26507491
6PKN22.91448664
7PDK42.81343370
8PDK32.81343370
9TAOK22.52542523
10PRPF4B2.47513602
11MOS2.39303623
12CAMK1G2.38636941
13FGFR42.31448454
14MAP3K142.31390703
15TESK12.28911721
16INSRR2.14505446
17ARAF2.01573788
18RIPK41.99886727
19BLK1.86829061
20IRAK41.81742929
21GRK71.81399158
22PIM21.80594373
23MYLK1.74240211
24PRKAA21.67872211
25PDK21.66464456
26MST1R1.61565324
27RIPK11.59157233
28LMTK21.58201243
29PIK3CA1.47547879
30IKBKE1.46652134
31ZAP701.43461965
32TAOK11.41443803
33IKBKB1.36037626
34TIE11.35408851
35TTN1.33653115
36FLT31.33527981
37LATS11.33124144
38OBSCN1.33047486
39TGFBR21.26335659
40MAP3K131.23047433
41MAP3K11.22085665
42PTK61.18161491
43FRK1.17051449
44PINK11.14094401
45IRAK21.13829696
46MAPK111.13666782
47NEK91.11811821
48TESK21.08940407
49FGFR21.08164789
50IRAK11.07640262
51PIK3CG1.04882424
52MAP2K41.04274764
53MATK1.04087630
54STK38L1.03825584
55CDC42BPA1.02903038
56DAPK21.01403271
57PHKG11.00574748
58PHKG21.00574748
59MAP3K70.96581107
60MAP4K10.96509147
61BMPR20.95222076
62PRKAA10.94628057
63MAP2K30.92006714
64ERBB40.90960518
65PDGFRA0.90898387
66MAPK120.89576877
67EPHB10.87187122
68JAK10.85720317
69JAK20.83869450
70KDR0.81842099
71EPHB20.80235306
72FGR0.79488162
73LIMK10.77252277
74MAP2K10.76262776
75TYK20.75888106
76ABL20.75066505
77PDPK10.75044691
78MAP3K30.74958059
79MET0.72473488
80PAK40.72430006
81STK100.70305405
82CHUK0.70178549
83FGFR30.69541967
84TXK0.69506486
85IRAK30.68759769
86MAP3K50.67551130
87PRKACG0.65314709
88HIPK20.65236231
89CDK60.64955615
90KSR20.62471818
91BRAF0.62368344
92EPHA30.59303776
93TBK10.58716814
94CSK0.57838416
95RET0.57349028
96IGF1R0.57113912
97LATS20.56587645
98MAPK40.56182948
99GSK3A0.55997566
100PDK10.51179853
101PRKD10.51118279
102NME20.49259322
103CDK90.47538901
104PRKCZ0.47089550
105GRK50.46711178
106MTOR0.45772179
107DAPK30.45452039
108PKN10.44710702
109MAPKAPK30.44435822
110SIK30.43656370
111CAMK10.43378666
112MAP2K60.43346136
113ILK0.42409090
114BMX0.42389114
115TAOK30.39663091
116PDGFRB0.39601154
117HCK0.39555219
118PAK30.39446938
119LYN0.38801633
120DMPK0.38701545
121FER0.38207253
122PTK2B0.37808025
123ICK0.36644423
124PTK20.34898187
125PAK10.34875053
126FGFR10.32674300
127CDK40.31569169
128SGK30.31138174
129PRKCH0.30457053
130CLK10.30388895
131CSF1R0.30003633
132CAMK2G0.29944362
133MAP3K60.29430824
134TRPM70.28721724
135EPHA20.27817986
136SYK0.27692712
137MAPKAPK20.27082507
138CAMKK20.26770350
139JAK30.26225180
140ABL10.25364787
141RPS6KB10.24510266
142MAPK70.24434002
143DDR20.23700849
144WNK40.23409759
145LRRK20.23323530
146GRK60.22633614
147STK30.22541320
148STK380.22294858
149MAP3K110.20639161
150ROCK10.19769494

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.35171624
2Propanoate metabolism_Homo sapiens_hsa006403.32072506
3Fatty acid degradation_Homo sapiens_hsa000713.17142485
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.14364579
5PPAR signaling pathway_Homo sapiens_hsa033202.81946652
6Fatty acid metabolism_Homo sapiens_hsa012122.80748702
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.80016907
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.78489027
9Nitrogen metabolism_Homo sapiens_hsa009102.70184214
10Malaria_Homo sapiens_hsa051442.60827898
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49974399
12Caffeine metabolism_Homo sapiens_hsa002322.48436199
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.39809155
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.39661455
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.36456010
16Arginine biosynthesis_Homo sapiens_hsa002202.35497259
17Osteoclast differentiation_Homo sapiens_hsa043802.34490695
18Fatty acid biosynthesis_Homo sapiens_hsa000612.34342298
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.33702807
20Tryptophan metabolism_Homo sapiens_hsa003802.32784248
21Other glycan degradation_Homo sapiens_hsa005112.26136680
22Butanoate metabolism_Homo sapiens_hsa006502.20525107
23Peroxisome_Homo sapiens_hsa041462.17558069
24Pertussis_Homo sapiens_hsa051332.17502345
25TNF signaling pathway_Homo sapiens_hsa046682.13404445
26Pyruvate metabolism_Homo sapiens_hsa006202.08905455
27Leishmaniasis_Homo sapiens_hsa051402.05846020
28NF-kappa B signaling pathway_Homo sapiens_hsa040642.03450331
29Complement and coagulation cascades_Homo sapiens_hsa046102.01274822
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.00948908
31Legionellosis_Homo sapiens_hsa051341.91095683
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88676086
33beta-Alanine metabolism_Homo sapiens_hsa004101.87957478
34Rheumatoid arthritis_Homo sapiens_hsa053231.76515755
35Fatty acid elongation_Homo sapiens_hsa000621.76323819
36Carbon metabolism_Homo sapiens_hsa012001.74574237
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.72891290
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.72800154
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.71691261
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62345951
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53728725
42Chemical carcinogenesis_Homo sapiens_hsa052041.52883983
43Salmonella infection_Homo sapiens_hsa051321.52086718
44Tuberculosis_Homo sapiens_hsa051521.50714821
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.48573533
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48129681
47Lysosome_Homo sapiens_hsa041421.47650750
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45258053
49Phenylalanine metabolism_Homo sapiens_hsa003601.40347823
50African trypanosomiasis_Homo sapiens_hsa051431.40210969
51Staphylococcus aureus infection_Homo sapiens_hsa051501.38518239
52Toxoplasmosis_Homo sapiens_hsa051451.34452985
53Histidine metabolism_Homo sapiens_hsa003401.34434838
54Fat digestion and absorption_Homo sapiens_hsa049751.33755556
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.31589844
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30793256
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.28136285
58Tyrosine metabolism_Homo sapiens_hsa003501.27951409
59Glycerolipid metabolism_Homo sapiens_hsa005611.27802940
60Influenza A_Homo sapiens_hsa051641.25678012
61Allograft rejection_Homo sapiens_hsa053301.24624724
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23496320
63Starch and sucrose metabolism_Homo sapiens_hsa005001.22183114
64Retinol metabolism_Homo sapiens_hsa008301.21990598
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21688095
66Biosynthesis of amino acids_Homo sapiens_hsa012301.20790189
67Jak-STAT signaling pathway_Homo sapiens_hsa046301.15096257
68Sulfur metabolism_Homo sapiens_hsa009201.12967249
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10406560
70Bile secretion_Homo sapiens_hsa049761.09047337
71Graft-versus-host disease_Homo sapiens_hsa053321.08957412
72Acute myeloid leukemia_Homo sapiens_hsa052211.08548683
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07829360
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06443842
75Hepatitis C_Homo sapiens_hsa051601.01651274
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98465985
77Selenocompound metabolism_Homo sapiens_hsa004500.97484416
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97382745
79ABC transporters_Homo sapiens_hsa020100.96775447
80Asthma_Homo sapiens_hsa053100.96146947
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92739385
82Hematopoietic cell lineage_Homo sapiens_hsa046400.92647486
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.89657061
84Folate biosynthesis_Homo sapiens_hsa007900.87857102
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86785332
86Sulfur relay system_Homo sapiens_hsa041220.86706778
87Shigellosis_Homo sapiens_hsa051310.85207699
88Bladder cancer_Homo sapiens_hsa052190.85185809
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.84658727
90Measles_Homo sapiens_hsa051620.84055839
91Lysine degradation_Homo sapiens_hsa003100.80196458
92Vitamin B6 metabolism_Homo sapiens_hsa007500.79767158
93Phagosome_Homo sapiens_hsa041450.79674906
94Pentose phosphate pathway_Homo sapiens_hsa000300.77067347
95Arginine and proline metabolism_Homo sapiens_hsa003300.76535078
96Viral myocarditis_Homo sapiens_hsa054160.75489804
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74517677
98Chemokine signaling pathway_Homo sapiens_hsa040620.73702742
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71621248
100Autoimmune thyroid disease_Homo sapiens_hsa053200.71220881
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70673167
102Galactose metabolism_Homo sapiens_hsa000520.67759123
103B cell receptor signaling pathway_Homo sapiens_hsa046620.67220952
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.66950488
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66453797
106Apoptosis_Homo sapiens_hsa042100.66155261
107Insulin resistance_Homo sapiens_hsa049310.65488066
108Glutathione metabolism_Homo sapiens_hsa004800.63842283
109VEGF signaling pathway_Homo sapiens_hsa043700.62865822
110Herpes simplex infection_Homo sapiens_hsa051680.61692195
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60437218
112Type I diabetes mellitus_Homo sapiens_hsa049400.60338264
113Hepatitis B_Homo sapiens_hsa051610.59984610
114Vitamin digestion and absorption_Homo sapiens_hsa049770.59885798
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59545643
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59456433
117AMPK signaling pathway_Homo sapiens_hsa041520.59049173
118Steroid biosynthesis_Homo sapiens_hsa001000.58015959
119Prolactin signaling pathway_Homo sapiens_hsa049170.57017970
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.54099800
121Metabolic pathways_Homo sapiens_hsa011000.47288739
122Glucagon signaling pathway_Homo sapiens_hsa049220.45586541
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43038903
124Chronic myeloid leukemia_Homo sapiens_hsa052200.40297229
125HIF-1 signaling pathway_Homo sapiens_hsa040660.39610020
126Fructose and mannose metabolism_Homo sapiens_hsa000510.39490870
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39274489
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.38755855
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36947816
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.34018554
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.33237603
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32210161
133Insulin signaling pathway_Homo sapiens_hsa049100.31181199
134Antigen processing and presentation_Homo sapiens_hsa046120.30597293
135Pancreatic cancer_Homo sapiens_hsa052120.30497078
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29599407
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.28135385
138Oxidative phosphorylation_Homo sapiens_hsa001900.20180688
139Parkinsons disease_Homo sapiens_hsa050120.16306308
140Linoleic acid metabolism_Homo sapiens_hsa005910.12355139
141Central carbon metabolism in cancer_Homo sapiens_hsa052300.11936388
142Prion diseases_Homo sapiens_hsa050200.08459641
143Alzheimers disease_Homo sapiens_hsa050100.07227761
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.06973804
145One carbon pool by folate_Homo sapiens_hsa006700.01549515
146Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1714354
147Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1610996
148Dilated cardiomyopathy_Homo sapiens_hsa05414-0.1441061
149Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.1353343
150Huntingtons disease_Homo sapiens_hsa05016-0.1148550
151Amoebiasis_Homo sapiens_hsa05146-0.1128877
152Protein digestion and absorption_Homo sapiens_hsa04974-0.1124261
153ECM-receptor interaction_Homo sapiens_hsa04512-0.1049142
154Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0963143
155Type II diabetes mellitus_Homo sapiens_hsa04930-0.0846977
156Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0747653
157Cardiac muscle contraction_Homo sapiens_hsa04260-0.0345212
158Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0069086
159Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0046784

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