G3BP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.39305757
2DNA strand elongation involved in DNA replication (GO:0006271)4.59415271
3DNA replication initiation (GO:0006270)4.53892948
4mitotic sister chromatid cohesion (GO:0007064)4.51695819
5protein localization to kinetochore (GO:0034501)4.48554553
6IMP biosynthetic process (GO:0006188)4.38792456
7folic acid-containing compound biosynthetic process (GO:0009396)4.38247173
8DNA strand elongation (GO:0022616)4.37096469
9nuclear pore organization (GO:0006999)4.30929972
10nucleobase biosynthetic process (GO:0046112)4.23726374
11maturation of SSU-rRNA (GO:0030490)4.19403290
12mitotic nuclear envelope disassembly (GO:0007077)4.11421771
13double-strand break repair via nonhomologous end joining (GO:0006303)4.10066353
14non-recombinational repair (GO:0000726)4.10066353
15ribosomal small subunit assembly (GO:0000028)4.09865160
16nuclear pore complex assembly (GO:0051292)4.09086506
17formation of translation preinitiation complex (GO:0001731)4.08099250
18telomere maintenance via semi-conservative replication (GO:0032201)4.08018665
19DNA replication-dependent nucleosome organization (GO:0034723)4.04708345
20DNA replication-dependent nucleosome assembly (GO:0006335)4.04708345
21establishment of viral latency (GO:0019043)3.99552470
22IMP metabolic process (GO:0046040)3.91289613
23viral transcription (GO:0019083)3.89911725
24protein complex localization (GO:0031503)3.88704577
25translational termination (GO:0006415)3.85760757
26membrane disassembly (GO:0030397)3.82688981
27nuclear envelope disassembly (GO:0051081)3.82688981
28purine nucleobase biosynthetic process (GO:0009113)3.80860898
29spindle checkpoint (GO:0031577)3.78221561
30protein localization to chromosome, centromeric region (GO:0071459)3.77790506
31pre-miRNA processing (GO:0031054)3.73667695
32negative regulation of mitotic sister chromatid separation (GO:2000816)3.72501986
33negative regulation of sister chromatid segregation (GO:0033046)3.72501986
34negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.72501986
35negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.72501986
36negative regulation of mitotic sister chromatid segregation (GO:0033048)3.72501986
37mitotic metaphase plate congression (GO:0007080)3.71241781
38DNA ligation (GO:0006266)3.69902152
39mitotic spindle checkpoint (GO:0071174)3.69124396
40regulation of centriole replication (GO:0046599)3.64610569
41telomere maintenance via recombination (GO:0000722)3.62424079
42ribosomal large subunit biogenesis (GO:0042273)3.62161789
43regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.60427023
44regulation of mitotic metaphase/anaphase transition (GO:0030071)3.60427023
45DNA replication checkpoint (GO:0000076)3.60240305
46mitotic recombination (GO:0006312)3.57527347
47translational elongation (GO:0006414)3.56247153
48ribosome assembly (GO:0042255)3.55917061
49translational initiation (GO:0006413)3.54140381
50cellular protein complex localization (GO:0034629)3.50089993
51regulation of sister chromatid segregation (GO:0033045)3.48026366
52regulation of mitotic sister chromatid separation (GO:0010965)3.48026366
53regulation of mitotic sister chromatid segregation (GO:0033047)3.48026366
54mitotic spindle assembly checkpoint (GO:0007094)3.47560499
55* DNA duplex unwinding (GO:0032508)3.45964438
56* DNA geometric change (GO:0032392)3.44554576
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.44156970
58ribosome biogenesis (GO:0042254)3.44083084
59spindle assembly checkpoint (GO:0071173)3.42620805
60ribonucleoprotein complex biogenesis (GO:0022613)3.42179031
61negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.41356441
62telomere maintenance via telomere lengthening (GO:0010833)3.38834857
63ribosomal small subunit biogenesis (GO:0042274)3.38009113
64mitotic sister chromatid segregation (GO:0000070)3.34478220
65DNA topological change (GO:0006265)3.34469766
66regulation of spindle organization (GO:0090224)3.34247338
67mitotic chromosome condensation (GO:0007076)3.33235413
68chromatin remodeling at centromere (GO:0031055)3.31536076
69metaphase plate congression (GO:0051310)3.29402200
70CENP-A containing nucleosome assembly (GO:0034080)3.27923468
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.25634049
72sister chromatid segregation (GO:0000819)3.25480519
73negative regulation of RNA splicing (GO:0033119)3.24081312
74response to X-ray (GO:0010165)3.23824881
75regulation of sister chromatid cohesion (GO:0007063)3.23727233
76DNA replication-independent nucleosome assembly (GO:0006336)3.22882562
77DNA replication-independent nucleosome organization (GO:0034724)3.22882562
78ATP-dependent chromatin remodeling (GO:0043044)3.20916916
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.18995169
80nucleotide-excision repair, DNA gap filling (GO:0006297)3.18970318
81regulation of posttranscriptional gene silencing (GO:0060147)3.17448718
82regulation of gene silencing by miRNA (GO:0060964)3.17448718
83regulation of gene silencing by RNA (GO:0060966)3.17448718
84SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.16882671
85L-serine metabolic process (GO:0006563)3.16218433
86negative regulation of DNA repair (GO:0045738)3.14624078
87heterochromatin organization (GO:0070828)3.13178220
88spliceosomal snRNP assembly (GO:0000387)3.10941171
89pore complex assembly (GO:0046931)3.08729096
90kinetochore organization (GO:0051383)3.08146784
91rRNA processing (GO:0006364)3.07846771
92protein targeting to ER (GO:0045047)3.07086345
93somatic recombination of immunoglobulin gene segments (GO:0016447)3.06975989
94cotranslational protein targeting to membrane (GO:0006613)3.06342106
95DNA double-strand break processing (GO:0000729)3.05903005
96negative regulation of DNA-dependent DNA replication (GO:2000104)3.04644902
97cellular protein complex disassembly (GO:0043624)3.04310925
98dosage compensation (GO:0007549)3.04288593
99regulation of histone H3-K9 methylation (GO:0051570)3.04272221
100regulation of translational fidelity (GO:0006450)3.03920852
101somatic hypermutation of immunoglobulin genes (GO:0016446)3.02153790
102somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02153790
103viral life cycle (GO:0019058)3.01485535
104nuclear envelope organization (GO:0006998)3.00563903
105regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.00324023
106regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98336700
107regulation of mitotic spindle checkpoint (GO:1903504)2.98336700
108negative regulation of mRNA metabolic process (GO:1903312)2.98261858
109chromatin assembly or disassembly (GO:0006333)2.98258808
110regulation of DNA endoreduplication (GO:0032875)2.98115676
111rRNA metabolic process (GO:0016072)2.97828925
112negative regulation of mRNA processing (GO:0050686)2.96558299
113somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.96243252
114somatic cell DNA recombination (GO:0016444)2.96243252
115mRNA splicing, via spliceosome (GO:0000398)2.95594098
116RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.95594098
117establishment of chromosome localization (GO:0051303)2.95064470
118RNA splicing, via transesterification reactions (GO:0000375)2.94912179
119negative regulation of mitosis (GO:0045839)2.94586574
120mitotic G2/M transition checkpoint (GO:0044818)2.94458601
121regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92716802
122attachment of spindle microtubules to kinetochore (GO:0008608)2.91693236
123establishment of protein localization to endoplasmic reticulum (GO:0072599)2.91669656
124translesion synthesis (GO:0019985)2.91353190
125peptidyl-arginine omega-N-methylation (GO:0035247)2.91222329
126positive regulation of chromosome segregation (GO:0051984)2.90643861
127protein complex disassembly (GO:0043241)2.88558228
128negative regulation of histone methylation (GO:0031061)2.86642039
129regulation of mitotic spindle organization (GO:0060236)2.86129976
130regulation of translational termination (GO:0006449)2.85370029
131establishment of integrated proviral latency (GO:0075713)2.85309462
132protein localization to endoplasmic reticulum (GO:0070972)2.83432519
133regulation of helicase activity (GO:0051095)2.83215020
134nuclear-transcribed mRNA catabolic process (GO:0000956)2.83049016
135* DNA conformation change (GO:0071103)2.82117657
136negative regulation of chromosome segregation (GO:0051985)2.81792835
137regulation of chromosome segregation (GO:0051983)2.80832800
138postreplication repair (GO:0006301)2.80790041
139histone exchange (GO:0043486)2.79395229
140regulation of centrosome cycle (GO:0046605)2.79348994
141DNA deamination (GO:0045006)2.79335926

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.10972089
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.28388165
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.27575583
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65748174
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.64506765
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08904491
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.08758531
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75403906
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.62276091
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58137316
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.38915188
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35846553
13* XRN2_22483619_ChIP-Seq_HELA_Human2.30326290
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.30262539
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27415638
16MYC_22102868_ChIP-Seq_BL_Human2.15093440
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.14351632
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14271251
19AR_21909140_ChIP-Seq_LNCAP_Human2.13561382
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07665492
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05482103
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.05228588
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96811058
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92886679
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91134709
26* VDR_23849224_ChIP-Seq_CD4+_Human1.88265788
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87934438
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81266131
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79627866
30FOXP3_21729870_ChIP-Seq_TREG_Human1.75394494
31TTF2_22483619_ChIP-Seq_HELA_Human1.74089131
32DCP1A_22483619_ChIP-Seq_HELA_Human1.70982543
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69099896
34CIITA_25753668_ChIP-Seq_RAJI_Human1.67312282
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66624753
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62818144
37GABP_19822575_ChIP-Seq_HepG2_Human1.62351951
38* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61352643
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60868860
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60240138
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.58874345
42* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56059751
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54261140
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51500491
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.51474014
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49513065
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46357958
48KDM5A_27292631_Chip-Seq_BREAST_Human1.44739235
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44629453
50ELK1_19687146_ChIP-ChIP_HELA_Human1.43972433
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41448126
52NANOG_16153702_ChIP-ChIP_HESCs_Human1.39242899
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35684881
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34274612
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.31469364
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30505897
57* VDR_21846776_ChIP-Seq_THP-1_Human1.27988891
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26997052
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26086266
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25636730
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25230831
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24854084
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24041193
64TFEB_21752829_ChIP-Seq_HELA_Human1.21978203
65* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21520357
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20195623
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.19856456
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19515106
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18308143
70SOX17_20123909_ChIP-Seq_XEN_Mouse1.18206439
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17700049
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16048697
73* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15577044
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15462118
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.13621299
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12823702
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12662909
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10978659
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08489891
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08166920
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07811550
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07782594
83* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07767834
84NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07750428
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05732510
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03912934
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03912934
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03912934
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02301932
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.01781319
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01479995
92CHD1_26751641_Chip-Seq_LNCaP_Human1.01302924
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00230638
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99881755
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99583898
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94044033
97* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93498962
98EWS_26573619_Chip-Seq_HEK293_Human0.92927666
99ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92403901
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.92373600
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89289501
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88958807
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88608811
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88155647
105EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86875212
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85820825
107NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85310223
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85109444
109MYC_18940864_ChIP-ChIP_HL60_Human0.84539459
110* SPI1_23547873_ChIP-Seq_NB4_Human0.84476026
111SALL1_21062744_ChIP-ChIP_HESCs_Human0.84424334
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83586850
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83414034
114SRF_21415370_ChIP-Seq_HL-1_Mouse0.83213468
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83144585
116TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82739142
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82340546
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81983760
119CLOCK_20551151_ChIP-Seq_293T_Human0.78743149
120WT1_19549856_ChIP-ChIP_CCG9911_Human0.76826260
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76459052

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.57624459
2MP0010094_abnormal_chromosome_stability4.08385551
3MP0004957_abnormal_blastocyst_morpholog4.01344243
4MP0003111_abnormal_nucleus_morphology4.00081632
5MP0003077_abnormal_cell_cycle3.59236497
6MP0008057_abnormal_DNA_replication3.32567488
7MP0010352_gastrointestinal_tract_polyps2.85871346
8MP0008007_abnormal_cellular_replicative2.68428674
9MP0008058_abnormal_DNA_repair2.58101741
10MP0003123_paternal_imprinting2.43448040
11MP0001730_embryonic_growth_arrest2.42873828
12MP0009697_abnormal_copulation2.37365133
13MP0008932_abnormal_embryonic_tissue2.35927762
14MP0002396_abnormal_hematopoietic_system2.35486045
15* MP0000350_abnormal_cell_proliferation2.25904489
16MP0010307_abnormal_tumor_latency1.99894111
17* MP0005380_embryogenesis_phenotype1.81728087
18* MP0001672_abnormal_embryogenesis/_devel1.81728087
19MP0001697_abnormal_embryo_size1.81203594
20MP0000490_abnormal_crypts_of1.72038919
21MP0005076_abnormal_cell_differentiation1.70943334
22MP0010030_abnormal_orbit_morphology1.69463833
23MP0002085_abnormal_embryonic_tissue1.67401581
24MP0004808_abnormal_hematopoietic_stem1.66918617
25MP0004197_abnormal_fetal_growth/weight/1.66447840
26* MP0003984_embryonic_growth_retardation1.66364499
27MP0002080_prenatal_lethality1.66303320
28* MP0002088_abnormal_embryonic_growth/wei1.64208053
29* MP0002084_abnormal_developmental_patter1.63420951
30MP0003705_abnormal_hypodermis_morpholog1.61393316
31MP0002086_abnormal_extraembryonic_tissu1.58210819
32MP0000537_abnormal_urethra_morphology1.54743584
33MP0003567_abnormal_fetal_cardiomyocyte1.53948941
34MP0002254_reproductive_system_inflammat1.48735749
35MP0003786_premature_aging1.47025265
36MP0002009_preneoplasia1.41662890
37MP0000313_abnormal_cell_death1.36425309
38MP0002019_abnormal_tumor_incidence1.36286081
39MP0001661_extended_life_span1.34628212
40MP0001293_anophthalmia1.32621770
41MP0009053_abnormal_anal_canal1.30673811
42MP0006054_spinal_hemorrhage1.30343341
43MP0003890_abnormal_embryonic-extraembry1.28305667
44MP0003121_genomic_imprinting1.27460951
45* MP0003718_maternal_effect1.26036944
46MP0008877_abnormal_DNA_methylation1.25110964
47MP0003763_abnormal_thymus_physiology1.24783177
48MP0000703_abnormal_thymus_morphology1.19258678
49MP0002796_impaired_skin_barrier1.19227130
50MP0009333_abnormal_splenocyte_physiolog1.15593548
51MP0003566_abnormal_cell_adhesion1.14346070
52MP0003119_abnormal_digestive_system1.11619699
53MP0000579_abnormal_nail_morphology1.10352297
54MP0004272_abnormal_basement_membrane1.04946505
55MP0004233_abnormal_muscle_weight1.04773318
56MP0005397_hematopoietic_system_phenotyp1.02476099
57MP0001545_abnormal_hematopoietic_system1.02476099
58MP0009278_abnormal_bone_marrow1.02289387
59MP0005023_abnormal_wound_healing1.01779333
60MP0009672_abnormal_birth_weight1.01417169
61MP0002398_abnormal_bone_marrow1.00550407
62MP0002722_abnormal_immune_system0.99168951
63MP0003315_abnormal_perineum_morphology0.98957412
64MP0006035_abnormal_mitochondrial_morpho0.98572880
65MP0003941_abnormal_skin_development0.96747296
66MP0004185_abnormal_adipocyte_glucose0.96532876
67MP0001849_ear_inflammation0.95074652
68MP0000858_altered_metastatic_potential0.94474276
69MP0002233_abnormal_nose_morphology0.93207098
70MP0001299_abnormal_eye_distance/0.92863818
71MP0004133_heterotaxia0.90940494
72MP0000689_abnormal_spleen_morphology0.89774293
73* MP0002111_abnormal_tail_morphology0.89583487
74MP0010678_abnormal_skin_adnexa0.88678846
75MP0000733_abnormal_muscle_development0.87630349
76MP0010234_abnormal_vibrissa_follicle0.85533161
77MP0000762_abnormal_tongue_morphology0.85113511
78MP0002092_abnormal_eye_morphology0.84974544
79MP0003937_abnormal_limbs/digits/tail_de0.84886736
80MP0002060_abnormal_skin_morphology0.83542497
81MP0003806_abnormal_nucleotide_metabolis0.80704646
82MP0002877_abnormal_melanocyte_morpholog0.80566036
83MP0009703_decreased_birth_body0.78989064
84MP0000358_abnormal_cell_content/0.78121898
85MP0002210_abnormal_sex_determination0.77792202
86MP0000477_abnormal_intestine_morphology0.77628499
87MP0002429_abnormal_blood_cell0.76651782
88MP0005384_cellular_phenotype0.75268802
89MP0000647_abnormal_sebaceous_gland0.74126743
90MP0003221_abnormal_cardiomyocyte_apopto0.73834770
91MP0005621_abnormal_cell_physiology0.73548703
92MP0006292_abnormal_olfactory_placode0.73534551
93MP0001188_hyperpigmentation0.73185466
94MP0001145_abnormal_male_reproductive0.72923099
95MP0002006_tumorigenesis0.72811920
96MP0002697_abnormal_eye_size0.72492169
97* MP0001915_intracranial_hemorrhage0.71243882
98MP0001727_abnormal_embryo_implantation0.71198188
99MP0003950_abnormal_plasma_membrane0.70994471
100MP0001286_abnormal_eye_development0.69605839
101MP0002925_abnormal_cardiovascular_devel0.69462691
102* MP0000428_abnormal_craniofacial_morphol0.69402955
103MP0000432_abnormal_head_morphology0.68142990
104MP0000627_abnormal_mammary_gland0.66952366
105MP0003385_abnormal_body_wall0.66396607
106MP0002653_abnormal_ependyma_morphology0.66268254
107MP0003755_abnormal_palate_morphology0.65832031
108MP0001216_abnormal_epidermal_layer0.65745246
109MP0003943_abnormal_hepatobiliary_system0.65349415
110MP0004264_abnormal_extraembryonic_tissu0.65320696
111MP0005501_abnormal_skin_physiology0.64715070
112MP0003935_abnormal_craniofacial_develop0.64348955
113MP0003115_abnormal_respiratory_system0.63900240
114MP0000716_abnormal_immune_system0.62699281
115MP0002160_abnormal_reproductive_system0.62526837
116MP0001177_atelectasis0.61890490
117MP0001929_abnormal_gametogenesis0.60400778
118MP0000377_abnormal_hair_follicle0.58980307
119MP0002938_white_spotting0.58883269
120MP0006072_abnormal_retinal_apoptosis0.58183847
121MP0008770_decreased_survivor_rate0.57914259
122MP0002075_abnormal_coat/hair_pigmentati0.57703824
123MP0001346_abnormal_lacrimal_gland0.57173222
124MP0003861_abnormal_nervous_system0.57018228
125MP0003448_altered_tumor_morphology0.56294494
126MP0005623_abnormal_meninges_morphology0.56214583
127MP0002932_abnormal_joint_morphology0.55681706
128MP0000653_abnormal_sex_gland0.55094622
129MP0000371_diluted_coat_color0.54628449
130MP0000266_abnormal_heart_morphology0.54372196
131MP0000750_abnormal_muscle_regeneration0.54350476
132MP0000465_gastrointestinal_hemorrhage0.53962179
133MP0001119_abnormal_female_reproductive0.52542468
134MP0005389_reproductive_system_phenotype0.52219088

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.11754739
2Colon cancer (HP:0003003)3.80934997
3Birth length less than 3rd percentile (HP:0003561)3.73684849
4Ependymoma (HP:0002888)3.73544545
5Nephroblastoma (Wilms tumor) (HP:0002667)3.66794824
6Selective tooth agenesis (HP:0001592)3.61910886
7Embryonal renal neoplasm (HP:0011794)3.54478779
8Abnormality of cells of the erythroid lineage (HP:0012130)3.38663003
9Medulloblastoma (HP:0002885)3.27815493
10Abnormal number of erythroid precursors (HP:0012131)3.11852216
11Degeneration of anterior horn cells (HP:0002398)3.01281952
12Abnormality of the anterior horn cell (HP:0006802)3.01281952
13Spastic diplegia (HP:0001264)2.94602791
14Chromsome breakage (HP:0040012)2.93699053
15Oral leukoplakia (HP:0002745)2.89774665
16Cortical dysplasia (HP:0002539)2.89486286
17Breast hypoplasia (HP:0003187)2.89228283
18Patellar aplasia (HP:0006443)2.75070169
19Chromosomal breakage induced by crosslinking agents (HP:0003221)2.70938659
20Agnosia (HP:0010524)2.70738504
21Rhabdomyosarcoma (HP:0002859)2.64964740
22Basal cell carcinoma (HP:0002671)2.62223588
23Aplasia/Hypoplasia of the patella (HP:0006498)2.59768745
24Abnormality of chromosome stability (HP:0003220)2.57733853
25Proximal placement of thumb (HP:0009623)2.55401106
26Neoplasm of the pancreas (HP:0002894)2.54907760
27Meckel diverticulum (HP:0002245)2.53932906
28Absent thumb (HP:0009777)2.53065869
29Deviation of the thumb (HP:0009603)2.51586263
30Trismus (HP:0000211)2.47421329
3111 pairs of ribs (HP:0000878)2.47048818
32Abnormal number of incisors (HP:0011064)2.44594891
33Myelodysplasia (HP:0002863)2.42131095
34Abnormality of the ileum (HP:0001549)2.41000960
35Missing ribs (HP:0000921)2.40405790
36Abnormality of the preputium (HP:0100587)2.40294715
37Aplastic anemia (HP:0001915)2.38815624
38Microvesicular hepatic steatosis (HP:0001414)2.36922737
39Absent radius (HP:0003974)2.36515687
40Carpal bone hypoplasia (HP:0001498)2.36417621
41Macrocytic anemia (HP:0001972)2.36176338
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.35697967
43Short 4th metacarpal (HP:0010044)2.35697967
44Pallor (HP:0000980)2.35468490
45Abnormality of the astrocytes (HP:0100707)2.34447165
46Astrocytoma (HP:0009592)2.34447165
47Increased nuchal translucency (HP:0010880)2.33911533
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.30647088
49Abnormality of methionine metabolism (HP:0010901)2.28551848
50Atresia of the external auditory canal (HP:0000413)2.25398251
51Rough bone trabeculation (HP:0100670)2.25116294
52Progressive external ophthalmoplegia (HP:0000590)2.22670313
53Abnormality of the calcaneus (HP:0008364)2.19877454
54Aplasia involving forearm bones (HP:0009822)2.18466398
55Absent forearm bone (HP:0003953)2.18466398
56Amaurosis fugax (HP:0100576)2.16757877
57Duodenal stenosis (HP:0100867)2.14727437
58Small intestinal stenosis (HP:0012848)2.14727437
59Thrombocytosis (HP:0001894)2.13451794
60Multiple enchondromatosis (HP:0005701)2.12641887
61Neoplasm of striated muscle (HP:0009728)2.11820123
62Neoplasm of the oral cavity (HP:0100649)2.11009080
63Neoplasm of the small intestine (HP:0100833)2.10094642
64Premature graying of hair (HP:0002216)2.09039142
65Biliary tract neoplasm (HP:0100574)2.06795237
66Microretrognathia (HP:0000308)2.06707654
67Glioma (HP:0009733)2.06458879
68Pancreatic islet-cell hyperplasia (HP:0004510)2.05762857
69Breast carcinoma (HP:0003002)2.05644004
70Tracheoesophageal fistula (HP:0002575)2.04427946
71Ectopic kidney (HP:0000086)2.04129139
72Supernumerary spleens (HP:0009799)2.03632148
73Uterine neoplasm (HP:0010784)2.03025993
74Abnormality of the labia minora (HP:0012880)2.00547586
75Neoplasm of the adrenal gland (HP:0100631)2.00534966
76High pitched voice (HP:0001620)2.00154487
77Embryonal neoplasm (HP:0002898)1.99574713
78Deep philtrum (HP:0002002)1.99336713
79Impulsivity (HP:0100710)1.99192365
80Neoplasm of the adrenal cortex (HP:0100641)1.98330229
81Shoulder girdle muscle weakness (HP:0003547)1.97883115
82Abnormal lung lobation (HP:0002101)1.95855178
83Facial cleft (HP:0002006)1.95118595
84Choanal atresia (HP:0000453)1.94576349
85Slender long bone (HP:0003100)1.92888108
86Squamous cell carcinoma (HP:0002860)1.90946420
87Sloping forehead (HP:0000340)1.90377908
88Increased density of long bones (HP:0006392)1.89700260
89Neoplasm of the colon (HP:0100273)1.89391965
90Angiofibromas (HP:0010615)1.89033932
91Adenoma sebaceum (HP:0009720)1.89033932
92Cafe-au-lait spot (HP:0000957)1.88756177
93Aplasia/hypoplasia of the humerus (HP:0006507)1.88286168
94Abnormality of the duodenum (HP:0002246)1.86940548
95Bone marrow hypocellularity (HP:0005528)1.86244885
96Preauricular skin tag (HP:0000384)1.85331384
97Cellular immunodeficiency (HP:0005374)1.85019696
98Abnormality of the umbilical cord (HP:0010881)1.84987853
99Prominent nose (HP:0000448)1.84262063
100Horseshoe kidney (HP:0000085)1.84185855
101Overlapping toe (HP:0001845)1.84083118
102High anterior hairline (HP:0009890)1.83437942
103Pelvic girdle muscle weakness (HP:0003749)1.83309807
104Ovarian neoplasm (HP:0100615)1.81061003
105Skin tags (HP:0010609)1.81006910
106Malignant gastrointestinal tract tumors (HP:0006749)1.80602506
107Gastrointestinal carcinoma (HP:0002672)1.80602506
108Acute myeloid leukemia (HP:0004808)1.80076942
109Atrophy/Degeneration involving motor neurons (HP:0007373)1.79733008
110Renal duplication (HP:0000075)1.79556171
111Glossoptosis (HP:0000162)1.79322798
112Abnormality of the carotid arteries (HP:0005344)1.78875928
113Neoplasm of the rectum (HP:0100743)1.78125845
114Clubbing of toes (HP:0100760)1.77717753
115Abnormality of abdominal situs (HP:0011620)1.76314468
116Abdominal situs inversus (HP:0003363)1.76314468
117Skull defect (HP:0001362)1.75115261
118Lymphoma (HP:0002665)1.75051984
119Progressive muscle weakness (HP:0003323)1.73976884
120Ankyloglossia (HP:0010296)1.73962020
121Triphalangeal thumb (HP:0001199)1.73847808
122Anal stenosis (HP:0002025)1.72814109
123Hypoglycemic seizures (HP:0002173)1.72610656
124Facial hemangioma (HP:0000329)1.69043264
125Abnormality of glycolysis (HP:0004366)1.68505712
126Short thumb (HP:0009778)1.68192871
127Asplenia (HP:0001746)1.67965152
128Aplasia/Hypoplasia of the sternum (HP:0006714)1.66952841
129IgM deficiency (HP:0002850)1.66694282
130Volvulus (HP:0002580)1.66387754
131Abnormality of aspartate family amino acid metabolism (HP:0010899)1.63129346
132Short middle phalanx of the 5th finger (HP:0004220)1.62697778
133Uterine leiomyosarcoma (HP:0002891)1.61509768
134Leiomyosarcoma (HP:0100243)1.61509768
135Short humerus (HP:0005792)1.61093033
136Stenosis of the external auditory canal (HP:0000402)1.60271095
137Secondary amenorrhea (HP:0000869)1.59608099
138Microglossia (HP:0000171)1.59596791
139Primitive neuroectodermal tumor (HP:0030065)1.59433595
140Neuroblastic tumors (HP:0004376)1.59433595
141Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.59433595
142Neuroblastoma (HP:0003006)1.59433595
143Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.59173505
144Arteriovenous malformation (HP:0100026)1.58885368
145Increased serum pyruvate (HP:0003542)1.58771664
146Postnatal microcephaly (HP:0005484)1.58595999
147Prominent metopic ridge (HP:0005487)1.58577534
148Papillary thyroid carcinoma (HP:0002895)1.58182643

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.01317565
2BUB13.94144429
3WEE13.75194315
4PBK2.83048924
5NEK22.62510197
6EEF2K2.59140300
7EIF2AK12.50844718
8SRPK12.28205057
9TSSK62.23876317
10CDK122.20577097
11TAF12.19594996
12PASK2.19471855
13RPS6KB22.10807054
14NEK12.05549069
15MAP3K102.02759557
16TESK22.01327955
17TTK1.99641811
18PKN21.90979078
19MKNK11.90359627
20VRK21.86421439
21SCYL21.78063672
22RPS6KA41.77915928
23CDK71.75461531
24TLK11.73889885
25TGFBR11.71176283
26ACVR1B1.69971131
27BRSK21.69115057
28STK101.66960423
29PLK11.66372685
30ATR1.59744010
31AURKB1.57440279
32MAP3K81.57175483
33NME21.57014591
34TRIM281.51682624
35DYRK31.51435207
36SMG11.50156137
37EPHA21.49828652
38CDK41.48428516
39FLT31.42334370
40PAK41.40824986
41PLK41.35467234
42EIF2AK31.30947982
43NUAK11.29691514
44MKNK21.23879154
45PLK31.23480839
46VRK11.22120303
47CHEK11.19006559
48CHEK21.17553499
49ERBB41.16126473
50TNIK1.15166142
51LRRK21.14334745
52MAP4K11.14062022
53STK41.09114016
54TRIB31.07776757
55AURKA1.05469288
56ALK1.04378432
57STK38L0.95206390
58CDK60.93215654
59BRD40.92372659
60PIM10.91406343
61BRSK10.89244313
62MAPKAPK30.88673352
63CDK20.85541517
64ATM0.85248139
65TESK10.82651503
66BCR0.82572501
67MAP2K30.82386357
68TTN0.82006620
69PNCK0.81828802
70KDR0.81242441
71MST1R0.76204338
72ERBB30.76066010
73NLK0.75794803
74MET0.73678210
75STK160.71861856
76MTOR0.69334416
77BMPR1B0.65339542
78JAK30.64213971
79PAK20.63753250
80CSNK2A20.63714017
81PDK20.62688293
82STK240.60918113
83PAK10.60346062
84ZAK0.58279801
85MELK0.58001669
86PIM20.57893438
87CDK10.57510117
88CSNK1G10.56919736
89BTK0.54634185
90ZAP700.53882962
91STK30.53559343
92MAP3K110.52471769
93CSNK2A10.51186932
94CDK90.50090258
95AKT20.49208844
96PTK60.48640992
97RPS6KA50.48602682
98NEK90.48148271
99NME10.46923016
100GRK60.46799012
101PLK20.46365417
102FGFR10.45164342
103CSNK1A1L0.41559320
104PRKCI0.40763730
105CAMK1G0.39283264
106YES10.38809970
107CLK10.38658710
108LATS10.37956379
109BRAF0.37267671
110LATS20.36620775
111CAMK1D0.36264973
112ILK0.35935208
113PRKDC0.35487000
114WNK30.33602690
115MAP3K30.33313725
116EIF2AK20.31124527
117CDK80.30691846
118CCNB10.30335414
119* CSNK1E0.30052459
120TAOK20.29599057
121CHUK0.29542558
122MAPKAPK20.29145088
123CSNK1G30.28894771
124MST40.27595842
125PDGFRA0.27265009
126CSF1R0.26819491
127LIMK10.26673741
128AKT10.25468137
129MAPK140.25334613
130STK390.25214912
131CDK30.20042969

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.86052009
2Mismatch repair_Homo sapiens_hsa034304.11605463
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42734231
4Spliceosome_Homo sapiens_hsa030403.37176855
5Ribosome_Homo sapiens_hsa030103.17904278
6RNA transport_Homo sapiens_hsa030133.13295503
7One carbon pool by folate_Homo sapiens_hsa006702.99932589
8Base excision repair_Homo sapiens_hsa034102.95811036
9Cell cycle_Homo sapiens_hsa041102.75632563
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.68277278
11Nucleotide excision repair_Homo sapiens_hsa034202.67294840
12Homologous recombination_Homo sapiens_hsa034402.64118656
13RNA polymerase_Homo sapiens_hsa030202.47620109
14Proteasome_Homo sapiens_hsa030502.30195321
15Pyrimidine metabolism_Homo sapiens_hsa002402.04738398
16Fanconi anemia pathway_Homo sapiens_hsa034601.97019016
17mRNA surveillance pathway_Homo sapiens_hsa030151.86416866
18Non-homologous end-joining_Homo sapiens_hsa034501.84979355
19RNA degradation_Homo sapiens_hsa030181.78446350
20p53 signaling pathway_Homo sapiens_hsa041151.70185193
21Vitamin B6 metabolism_Homo sapiens_hsa007501.60439470
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52363014
23Systemic lupus erythematosus_Homo sapiens_hsa053221.46803613
24Basal transcription factors_Homo sapiens_hsa030221.37434831
25Pyruvate metabolism_Homo sapiens_hsa006201.33503247
26Viral carcinogenesis_Homo sapiens_hsa052031.26989061
27Epstein-Barr virus infection_Homo sapiens_hsa051691.23461412
28Steroid biosynthesis_Homo sapiens_hsa001001.23219251
29Antigen processing and presentation_Homo sapiens_hsa046121.20187607
30Propanoate metabolism_Homo sapiens_hsa006401.19911179
31Protein export_Homo sapiens_hsa030601.19667668
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16113925
33Herpes simplex infection_Homo sapiens_hsa051681.06805156
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05571482
35HTLV-I infection_Homo sapiens_hsa051661.01709038
36Cyanoamino acid metabolism_Homo sapiens_hsa004600.98246011
37MicroRNAs in cancer_Homo sapiens_hsa052060.97648900
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97622804
39Purine metabolism_Homo sapiens_hsa002300.96019210
40Thyroid cancer_Homo sapiens_hsa052160.94166829
41Selenocompound metabolism_Homo sapiens_hsa004500.93652552
42Small cell lung cancer_Homo sapiens_hsa052220.92722488
43Biosynthesis of amino acids_Homo sapiens_hsa012300.90987908
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90356246
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84731010
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83627292
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81899609
48Oocyte meiosis_Homo sapiens_hsa041140.81530859
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80630133
50Legionellosis_Homo sapiens_hsa051340.79463114
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77509882
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77164365
53Chronic myeloid leukemia_Homo sapiens_hsa052200.76052743
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75635156
55Pentose phosphate pathway_Homo sapiens_hsa000300.73386454
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.71584606
57Basal cell carcinoma_Homo sapiens_hsa052170.69911431
58Fatty acid elongation_Homo sapiens_hsa000620.68022079
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67917678
60Notch signaling pathway_Homo sapiens_hsa043300.65953781
61Hippo signaling pathway_Homo sapiens_hsa043900.65680708
62Colorectal cancer_Homo sapiens_hsa052100.64756001
63Primary immunodeficiency_Homo sapiens_hsa053400.64621190
64Apoptosis_Homo sapiens_hsa042100.64601386
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61628952
66Viral myocarditis_Homo sapiens_hsa054160.60671354
67Bladder cancer_Homo sapiens_hsa052190.59865691
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.59645410
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59008096
70TGF-beta signaling pathway_Homo sapiens_hsa043500.57474402
71Measles_Homo sapiens_hsa051620.55230760
72Hepatitis B_Homo sapiens_hsa051610.54860726
73Sulfur relay system_Homo sapiens_hsa041220.53938588
74Shigellosis_Homo sapiens_hsa051310.53487922
75Adherens junction_Homo sapiens_hsa045200.52735534
76Acute myeloid leukemia_Homo sapiens_hsa052210.52529225
77Alcoholism_Homo sapiens_hsa050340.52528979
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.50821446
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49819509
80Folate biosynthesis_Homo sapiens_hsa007900.49260819
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.48875709
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48267281
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46855557
84Carbon metabolism_Homo sapiens_hsa012000.46571106
85HIF-1 signaling pathway_Homo sapiens_hsa040660.44845739
86Fatty acid metabolism_Homo sapiens_hsa012120.44030417
87N-Glycan biosynthesis_Homo sapiens_hsa005100.43618566
88Pathways in cancer_Homo sapiens_hsa052000.42615533
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40678008
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39565274
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36119286
92Proteoglycans in cancer_Homo sapiens_hsa052050.36110971
93Hedgehog signaling pathway_Homo sapiens_hsa043400.35645791
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.35139882
95mTOR signaling pathway_Homo sapiens_hsa041500.34717057
96Prostate cancer_Homo sapiens_hsa052150.34323920
97Lysine degradation_Homo sapiens_hsa003100.33634252
98Influenza A_Homo sapiens_hsa051640.33039392
99Non-small cell lung cancer_Homo sapiens_hsa052230.32945103
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31477656
101Pancreatic cancer_Homo sapiens_hsa052120.30121390
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29285170
103Metabolic pathways_Homo sapiens_hsa011000.27445523
104Arginine and proline metabolism_Homo sapiens_hsa003300.27431963
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26949024
106Hematopoietic cell lineage_Homo sapiens_hsa046400.25947304
107Sulfur metabolism_Homo sapiens_hsa009200.25845420
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25238522
109Galactose metabolism_Homo sapiens_hsa000520.24365654
110B cell receptor signaling pathway_Homo sapiens_hsa046620.23118054
111Leishmaniasis_Homo sapiens_hsa051400.23017856
112Glutathione metabolism_Homo sapiens_hsa004800.22997186
113T cell receptor signaling pathway_Homo sapiens_hsa046600.22968025
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22592806
115Tight junction_Homo sapiens_hsa045300.22386078
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.22212775
117Arginine biosynthesis_Homo sapiens_hsa002200.22082273
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21458306
119Wnt signaling pathway_Homo sapiens_hsa043100.20908261
120Endometrial cancer_Homo sapiens_hsa052130.20735657
121Toxoplasmosis_Homo sapiens_hsa051450.20397260
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20138730
123Vitamin digestion and absorption_Homo sapiens_hsa049770.19817407
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19569259
125Melanoma_Homo sapiens_hsa052180.19393835
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13920705
127Fatty acid degradation_Homo sapiens_hsa000710.13844564
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.11130337

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