G6PC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)8.16174512
2endocrine pancreas development (GO:0031018)7.83716872
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.97916625
4COPII vesicle coating (GO:0048208)6.95507454
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.95453001
6peptide hormone processing (GO:0016486)6.84312637
7signal peptide processing (GO:0006465)6.72108877
8regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022356.45996897
9regulation of type B pancreatic cell apoptotic process (GO:2000674)6.26554481
10protein retention in ER lumen (GO:0006621)6.03350962
11sequestering of metal ion (GO:0051238)6.01053662
12negative regulation of protein oligomerization (GO:0032460)5.97738400
13glandular epithelial cell differentiation (GO:0002067)5.95709238
14activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.55349374
15insulin secretion (GO:0030073)5.45357343
16positive regulation of respiratory burst (GO:0060267)5.40221071
17type B pancreatic cell development (GO:0003323)5.39689823
18exocrine pancreas development (GO:0031017)5.32393675
19positive regulation of nuclease activity (GO:0032075)5.29239006
20negative regulation of acute inflammatory response (GO:0002674)5.20257755
21vesicle coating (GO:0006901)5.16810899
22positive regulation of insulin secretion (GO:0032024)5.13707825
23negative regulation of gluconeogenesis (GO:0045721)5.09440240
24glandular epithelial cell development (GO:0002068)5.08518175
25ER overload response (GO:0006983)5.05727259
26fatty acid homeostasis (GO:0055089)4.88200440
27regulation of nuclease activity (GO:0032069)4.83835967
28inositol phosphate catabolic process (GO:0071545)4.81922055
29endoplasmic reticulum unfolded protein response (GO:0030968)4.67596911
30cellular response to unfolded protein (GO:0034620)4.60955639
31* regulation of insulin secretion (GO:0050796)4.58095812
32positive regulation of protein autophosphorylation (GO:0031954)4.57782988
33chemosensory behavior (GO:0007635)4.54357262
34cellular response to topologically incorrect protein (GO:0035967)4.50627792
35phosphorylated carbohydrate dephosphorylation (GO:0046838)4.48040742
36inositol phosphate dephosphorylation (GO:0046855)4.48040742
37negative regulation of glycoprotein biosynthetic process (GO:0010561)4.45413735
38cellular ketone body metabolic process (GO:0046950)4.44210400
39ER-nucleus signaling pathway (GO:0006984)4.41015013
40detection of calcium ion (GO:0005513)4.39294230
41ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.37570441
42negative regulation of hormone biosynthetic process (GO:0032353)4.37502237
43intra-Golgi vesicle-mediated transport (GO:0006891)4.36587704
44negative regulation of glycogen metabolic process (GO:0070874)4.34473416
45* regulation of peptide hormone secretion (GO:0090276)4.18909552
46negative regulation of norepinephrine secretion (GO:0010700)4.16804324
47positive regulation of peptide hormone secretion (GO:0090277)4.15744808
48negative regulation of insulin secretion (GO:0046676)4.13154007
49nitric oxide mediated signal transduction (GO:0007263)4.12145283
50* regulation of peptide secretion (GO:0002791)4.11050628
51water-soluble vitamin biosynthetic process (GO:0042364)4.06737525
52columnar/cuboidal epithelial cell development (GO:0002066)4.02948439
53positive regulation of peptide secretion (GO:0002793)4.01289411
54cellular response to vitamin D (GO:0071305)3.98535349
55negative regulation of catecholamine secretion (GO:0033604)3.95097144
56cellular zinc ion homeostasis (GO:0006882)3.93563115
57positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.92453808
58ketone body metabolic process (GO:1902224)3.92379414
59positive regulation of glycogen biosynthetic process (GO:0045725)3.91681772
60peptide hormone secretion (GO:0030072)3.91043289
61protein N-linked glycosylation via asparagine (GO:0018279)3.86901334
62ER to Golgi vesicle-mediated transport (GO:0006888)3.86034656
63peptidyl-asparagine modification (GO:0018196)3.85003984
64peptide secretion (GO:0002790)3.82756048
65negative regulation of neurological system process (GO:0031645)3.80267050
66polyol catabolic process (GO:0046174)3.77431993
67response to endoplasmic reticulum stress (GO:0034976)3.76742473
68positive regulation of macroautophagy (GO:0016239)3.76092149
69negative regulation of hormone metabolic process (GO:0032351)3.75254887
70protein localization to Golgi apparatus (GO:0034067)3.69470308
71toxin metabolic process (GO:0009404)3.69463848
72glycerophospholipid catabolic process (GO:0046475)3.67467125
73negative regulation of bone resorption (GO:0045779)3.66251950
74* regulation of hormone secretion (GO:0046883)3.64607881
75regulation of hexokinase activity (GO:1903299)3.62194318
76regulation of glucokinase activity (GO:0033131)3.62194318
77positive regulation of response to nutrient levels (GO:0032109)3.61253510
78positive regulation of response to extracellular stimulus (GO:0032106)3.61253510
79negative regulation of peptide hormone secretion (GO:0090278)3.60055002
80response to unfolded protein (GO:0006986)3.59648356
81protein N-linked glycosylation (GO:0006487)3.53860800
82regulation of glucocorticoid secretion (GO:2000849)3.51538734
83response to topologically incorrect protein (GO:0035966)3.51233621
84negative regulation of peptide secretion (GO:0002792)3.47223111
85response to hexose (GO:0009746)3.44580067
86positive regulation of nitric-oxide synthase activity (GO:0051000)3.44418424
87regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.43500661
88macroautophagy (GO:0016236)3.43073331
89positive regulation of glycogen metabolic process (GO:0070875)3.42070727
90epithelial cell fate commitment (GO:0072148)3.41297980
91astrocyte differentiation (GO:0048708)3.41133347
92response to glucose (GO:0009749)3.38249644
93* regulation of peptide transport (GO:0090087)3.37930007
94regulation of glycolytic process (GO:0006110)3.37816976
95positive regulation of insulin receptor signaling pathway (GO:0046628)3.35504117
96Golgi organization (GO:0007030)3.34853103
97negative regulation of glycoprotein metabolic process (GO:1903019)3.33954286
98positive regulation of hormone secretion (GO:0046887)3.31869794
99response to monosaccharide (GO:0034284)3.27302491
100dendritic spine morphogenesis (GO:0060997)3.25425853
101negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.24634503
102righting reflex (GO:0060013)3.23226964
103purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.21096579
1043-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.21096579
105nucleoside diphosphate catabolic process (GO:0009134)3.20875401
106interleukin-1-mediated signaling pathway (GO:0070498)3.19207619
107kidney morphogenesis (GO:0060993)3.17983046
108glucosamine-containing compound catabolic process (GO:1901072)3.16966379
109positive regulation of glycolytic process (GO:0045821)3.15329559
110L-alpha-amino acid transmembrane transport (GO:1902475)3.12902444
111lactate metabolic process (GO:0006089)3.12184606
112cellular response to hepatocyte growth factor stimulus (GO:0035729)3.11966410
113response to hepatocyte growth factor (GO:0035728)3.11966410
114regulation of Golgi to plasma membrane protein transport (GO:0042996)3.10104393
115Golgi vesicle transport (GO:0048193)3.09396851
116regulation of oxidative phosphorylation (GO:0002082)3.07471352
117hormone secretion (GO:0046879)3.07254412
1184-hydroxyproline metabolic process (GO:0019471)3.06198255
119peptide transport (GO:0015833)3.05330432
120GDP-mannose metabolic process (GO:0019673)3.04564408
121respiratory chain complex IV assembly (GO:0008535)3.04337246
122zinc ion homeostasis (GO:0055069)3.01428887
123protein targeting to Golgi (GO:0000042)3.00580953
124negative regulation of Ras GTPase activity (GO:0034261)2.96449911
125eosinophil chemotaxis (GO:0048245)2.95985346
126intestinal epithelial cell development (GO:0060576)2.95424233
127inner ear receptor cell development (GO:0060119)2.95317846
128cellular response to glucagon stimulus (GO:0071377)2.91786151
129negative regulation of bone remodeling (GO:0046851)2.90816630
130regulation of energy homeostasis (GO:2000505)2.89591992
131hormone transport (GO:0009914)2.89477435
132xenobiotic catabolic process (GO:0042178)2.88949852
133positive regulation of vasodilation (GO:0045909)2.87201122
134positive regulation of growth hormone secretion (GO:0060124)2.86108626
135regulation of autophagic vacuole assembly (GO:2000785)2.85875663
136negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85184744
137response to carbohydrate (GO:0009743)2.85180118
138positive regulation of glucose metabolic process (GO:0010907)2.82700064
139nitric oxide biosynthetic process (GO:0006809)2.81432353
140zinc ion transmembrane transport (GO:0071577)2.80099301
141neuromuscular process controlling posture (GO:0050884)2.79847713
142regulation of feeding behavior (GO:0060259)2.78718460
143positive regulation of cellular carbohydrate metabolic process (GO:0010676)2.77602661
144positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.77362424
145regulation of calcium ion-dependent exocytosis (GO:0017158)2.75971725
146regulation of glucocorticoid metabolic process (GO:0031943)2.73977445
147startle response (GO:0001964)2.71724330
148zinc ion transport (GO:0006829)2.71566891
149regulation of cellular carbohydrate catabolic process (GO:0043471)2.69424371
150regulation of carbohydrate catabolic process (GO:0043470)2.69424371
151cytochrome complex assembly (GO:0017004)2.68988573
152RNA destabilization (GO:0050779)2.68574773
153aggressive behavior (GO:0002118)2.68435399
154positive regulation of TOR signaling (GO:0032008)2.68146381
155regulation of protein glycosylation (GO:0060049)2.66451296
156response to lipoprotein particle (GO:0055094)2.62813846
157valine metabolic process (GO:0006573)2.62343940
158brain morphogenesis (GO:0048854)2.62195315
159regulation of protein autophosphorylation (GO:0031952)2.61950163
160ferric iron transport (GO:0015682)2.61068402
161trivalent inorganic cation transport (GO:0072512)2.61068402
162dentate gyrus development (GO:0021542)2.60694119
163Golgi transport vesicle coating (GO:0048200)11.4056672
164COPI coating of Golgi vesicle (GO:0048205)11.4056672

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.54810444
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary5.10217430
3PDX1_19855005_ChIP-ChIP_MIN6_Mouse4.28931782
4GATA1_22025678_ChIP-Seq_K562_Human4.24816027
5GBX2_23144817_ChIP-Seq_PC3_Human2.66588801
6PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.23624424
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12042857
8CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.87506602
9CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86549088
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82745026
11SOX2_27498859_Chip-Seq_STOMACH_Mouse1.81179287
12SMAD4_21799915_ChIP-Seq_A2780_Human1.76140670
13FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.72298702
14IGF1R_20145208_ChIP-Seq_DFB_Human1.71522852
15TFEB_21752829_ChIP-Seq_HELA_Human1.70370182
16REST_21632747_ChIP-Seq_MESCs_Mouse1.70171592
17ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69522330
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.68811811
19P300_19829295_ChIP-Seq_ESCs_Human1.67208103
20NR3C1_23031785_ChIP-Seq_PC12_Mouse1.65539050
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65394028
22REST_19997604_ChIP-ChIP_NEURONS_Mouse1.65093190
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62944625
24FUS_26573619_Chip-Seq_HEK293_Human1.57004073
25HTT_18923047_ChIP-ChIP_STHdh_Human1.56892007
26ZNF274_21170338_ChIP-Seq_K562_Hela1.56522160
27AR_25329375_ChIP-Seq_VCAP_Human1.56199617
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55213677
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.54297878
30TAF15_26573619_Chip-Seq_HEK293_Human1.54203967
31SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.50917257
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49385204
33AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.48915505
34FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.48871884
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47665139
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47621906
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47588023
38OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.46389023
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45204626
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43730332
41* NANOG_18555785_Chip-Seq_ESCs_Mouse1.43723706
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40927475
43FOXA1_25552417_ChIP-Seq_VCAP_Human1.37372779
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37130007
45ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35580649
46CBP_20019798_ChIP-Seq_JUKART_Human1.35305002
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35305002
48ER_23166858_ChIP-Seq_MCF-7_Human1.35187287
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.34974932
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34512476
51P53_22387025_ChIP-Seq_ESCs_Mouse1.34253857
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.33981342
53CDX2_22108803_ChIP-Seq_LS180_Human1.32507562
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.32367204
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32049437
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30342726
57EWS_26573619_Chip-Seq_HEK293_Human1.30294360
58* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30149139
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29820287
60TCF4_23295773_ChIP-Seq_U87_Human1.29069622
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28665572
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.28051654
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.27975718
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27791204
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26458570
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26061737
67ERG_20517297_ChIP-Seq_VCAP_Human1.24703158
68FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24508356
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23535222
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23352759
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23123389
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22406458
73* CMYC_18555785_Chip-Seq_ESCs_Mouse1.21785519
74CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19072865
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18657336
76STAT3_23295773_ChIP-Seq_U87_Human1.18561646
77SOX2_19829295_ChIP-Seq_ESCs_Human1.18455022
78NANOG_19829295_ChIP-Seq_ESCs_Human1.18455022
79TCF4_22108803_ChIP-Seq_LS180_Human1.17949723
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17947128
81FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.17776586
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17009763
83LXR_22158963_ChIP-Seq_LIVER_Mouse1.15613624
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15174394
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15097632
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.14558821
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14248510
88SOX2_18555785_Chip-Seq_ESCs_Mouse1.13717769
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.13689605
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12611803
91* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11278640
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10798745
93PKCTHETA_26484144_Chip-Seq_BREAST_Human1.10626356
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.09988773
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09449199
96* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09221202
97TBL1_22424771_ChIP-Seq_293T_Human1.07226939
98FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07027322
99* CTCF_18555785_Chip-Seq_ESCs_Mouse1.06582724
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05749570
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05562978
102NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04775032
103* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04125662
104OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03510589
105* P300_18555785_Chip-Seq_ESCs_Mouse1.03110020
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02770306
107SALL1_21062744_ChIP-ChIP_HESCs_Human1.02460447
108TP53_22573176_ChIP-Seq_HFKS_Human1.02247538
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.01934265
110CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01718930
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01436721
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01415229
113RXR_22158963_ChIP-Seq_LIVER_Mouse1.01162395
114PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00245641
115RUNX2_22187159_ChIP-Seq_PCA_Human1.00204182
116VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00172780
117VDR_22108803_ChIP-Seq_LS180_Human0.99863492
118PRDM14_20953172_ChIP-Seq_ESCs_Human0.99550346
119NFYB_21822215_ChIP-Seq_K562_Human0.99333089
120PHF8_20622853_ChIP-Seq_HELA_Human0.99165089
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98378224
122* GATA1_19941826_ChIP-Seq_K562_Human0.97435515
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96589801
124FLI1_21867929_ChIP-Seq_TH2_Mouse0.96131550
125TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95516254
126ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94208981
127POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93870300
128CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93655758
129GATA3_27048872_Chip-Seq_THYMUS_Human0.93456651
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92861043
131EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91265486
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91022996
133PIAS1_25552417_ChIP-Seq_VCAP_Human0.90526177
134MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89801283
135FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89795986
136TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88091087
137CLOCK_20551151_ChIP-Seq_293T_Human0.85696583
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.85635751
139GATA3_24758297_ChIP-Seq_MCF-7_Human0.85579411
140YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85372466
141* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85214218
142NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84051381
143ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83962585
144SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.83649477
145GATA3_26560356_Chip-Seq_TH2_Human0.81522477
146SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81337665
147JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.81257120
148AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80654528
149GF1B_26923725_Chip-Seq_HPCs_Mouse0.80597127
150RARB_27405468_Chip-Seq_BRAIN_Mouse0.80073537
151SMAD3_21741376_ChIP-Seq_ESCs_Human0.79662344
152EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78098217
153CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.77548009
154FOXA2_19822575_ChIP-Seq_HepG2_Human0.77397121
155GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77338305
156ZFX_18555785_ChIP-Seq_MESCs_Mouse0.77303554
157PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77237430
158ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.77206910
159BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.74914946
160STAT3_18555785_Chip-Seq_ESCs_Mouse0.74757385
161MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.74752130
162RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.73916630
163SOX2_20726797_ChIP-Seq_SW620_Human0.73807193
164FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73276647
165FOXA1_25329375_ChIP-Seq_VCAP_Human0.73276647
166OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.72786506
167ETS1_22383799_ChIP-Seq_G1ME_Mouse0.72530996
168BCAT_22108803_ChIP-Seq_LS180_Human0.72318457
169SOX2_21211035_ChIP-Seq_LN229_Gbm0.71955829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog6.07032101
2MP0003283_abnormal_digestive_organ5.22942430
3MP0004043_abnormal_pH_regulation4.78859681
4MP0002693_abnormal_pancreas_physiology4.58419905
5MP0009780_abnormal_chondrocyte_physiolo4.49466333
6MP0001944_abnormal_pancreas_morphology3.99328158
7MP0010234_abnormal_vibrissa_follicle3.97494838
8MP0002909_abnormal_adrenal_gland3.94879869
9MP0003195_calcinosis3.73145620
10MP0005379_endocrine/exocrine_gland_phen3.61560741
11MP0010386_abnormal_urinary_bladder3.60732761
12MP0000013_abnormal_adipose_tissue3.59182024
13MP0000678_abnormal_parathyroid_gland3.54919622
14MP0003183_abnormal_peptide_metabolism3.09066086
15MP0005220_abnormal_exocrine_pancreas2.86674581
16MP0002837_dystrophic_cardiac_calcinosis2.75211691
17MP0008877_abnormal_DNA_methylation2.42666817
18MP0006072_abnormal_retinal_apoptosis2.39928631
19* MP0002078_abnormal_glucose_homeostasis2.37114626
20MP0005646_abnormal_pituitary_gland2.24910559
21MP0003123_paternal_imprinting2.18209177
22MP0001986_abnormal_taste_sensitivity1.96469517
23MP0009046_muscle_twitch1.94869307
24MP0004264_abnormal_extraembryonic_tissu1.93879584
25MP0001984_abnormal_olfaction1.93302514
26MP0000003_abnormal_adipose_tissue1.85217043
27MP0002638_abnormal_pupillary_reflex1.72764613
28MP0002822_catalepsy1.69900099
29MP0003172_abnormal_lysosome_physiology1.65911169
30MP0002254_reproductive_system_inflammat1.65210826
31MP0003300_gastrointestinal_ulcer1.65197365
32MP0002928_abnormal_bile_duct1.64922011
33MP0000462_abnormal_digestive_system1.64601200
34MP0005058_abnormal_lysosome_morphology1.58402095
35MP0002896_abnormal_bone_mineralization1.57870268
36MP0003121_genomic_imprinting1.51840735
37MP0000613_abnormal_salivary_gland1.50066219
38MP0005084_abnormal_gallbladder_morpholo1.49003460
39MP0001765_abnormal_ion_homeostasis1.47602562
40MP0003953_abnormal_hormone_level1.46801108
41MP0002234_abnormal_pharynx_morphology1.44743787
42MP0003122_maternal_imprinting1.42211989
43MP0005332_abnormal_amino_acid1.40658668
44MP0000516_abnormal_urinary_system1.40656112
45MP0005367_renal/urinary_system_phenotyp1.40656112
46MP0010329_abnormal_lipoprotein_level1.40036670
47MP0008961_abnormal_basal_metabolism1.36119135
48MP0002876_abnormal_thyroid_physiology1.33984561
49MP0003868_abnormal_feces_composition1.33815589
50MP0009643_abnormal_urine_homeostasis1.31841271
51MP0002163_abnormal_gland_morphology1.31252186
52MP0005257_abnormal_intraocular_pressure1.30234311
53MP0002139_abnormal_hepatobiliary_system1.29593454
54MP0002102_abnormal_ear_morphology1.28647181
55MP0005310_abnormal_salivary_gland1.28499190
56MP0005645_abnormal_hypothalamus_physiol1.26660238
57MP0010678_abnormal_skin_adnexa1.22387791
58MP0004270_analgesia1.21676672
59MP0005535_abnormal_body_temperature1.21144272
60MP0000427_abnormal_hair_cycle1.19200850
61MP0002138_abnormal_hepatobiliary_system1.19034189
62MP0002090_abnormal_vision1.14154306
63MP0000631_abnormal_neuroendocrine_gland1.09239609
64MP0002277_abnormal_respiratory_mucosa1.09207549
65MP0009745_abnormal_behavioral_response1.06053443
66MP0005365_abnormal_bile_salt1.05144352
67MP0005551_abnormal_eye_electrophysiolog1.05093565
68MP0003252_abnormal_bile_duct1.04449624
69MP0004510_myositis1.03064688
70MP0006054_spinal_hemorrhage1.01539947
71MP0004885_abnormal_endolymph1.01414244
72MP0004924_abnormal_behavior1.01227214
73MP0005386_behavior/neurological_phenoty1.01227214
74MP0002064_seizures1.01024041
75MP0010352_gastrointestinal_tract_polyps1.00234109
76MP0005075_abnormal_melanosome_morpholog0.98226083
77MP0005636_abnormal_mineral_homeostasis0.98059258
78MP0001756_abnormal_urination0.98047100
79MP0003119_abnormal_digestive_system0.96860563
80MP0004142_abnormal_muscle_tone0.96807673
81MP0002938_white_spotting0.96645110
82MP0003633_abnormal_nervous_system0.96061409
83MP0000681_abnormal_thyroid_gland0.95369560
84MP0001905_abnormal_dopamine_level0.93483259
85MP0004019_abnormal_vitamin_homeostasis0.91451720
86MP0001270_distended_abdomen0.90661299
87MP0001661_extended_life_span0.89536783
88MP0003890_abnormal_embryonic-extraembry0.88270936
89MP0001502_abnormal_circadian_rhythm0.87784397
90MP0002557_abnormal_social/conspecific_i0.87727950
91MP0003959_abnormal_lean_body0.87197527
92MP0005448_abnormal_energy_balance0.86717698
93MP0008872_abnormal_physiological_respon0.85252654
94MP0002272_abnormal_nervous_system0.83928660
95MP0005253_abnormal_eye_physiology0.83867787
96MP0002295_abnormal_pulmonary_circulatio0.82411088
97MP0006036_abnormal_mitochondrial_physio0.81615558
98MP0003866_abnormal_defecation0.80992230
99MP0002572_abnormal_emotion/affect_behav0.80141632
100MP0009672_abnormal_birth_weight0.79769112
101MP0000230_abnormal_systemic_arterial0.79640112
102MP0005174_abnormal_tail_pigmentation0.79607503
103MP0000538_abnormal_urinary_bladder0.76010667
104MP0005375_adipose_tissue_phenotype0.75783853
105MP0000639_abnormal_adrenal_gland0.75053917
106MP0003011_delayed_dark_adaptation0.73482197
107MP0005187_abnormal_penis_morphology0.73293228
108MP0002160_abnormal_reproductive_system0.72731334
109MP0001970_abnormal_pain_threshold0.72553902
110MP0001666_abnormal_nutrient_absorption0.71274602
111MP0001299_abnormal_eye_distance/0.69564825
112MP0003879_abnormal_hair_cell0.69179159
113MP0000015_abnormal_ear_pigmentation0.68932731
114MP0002166_altered_tumor_susceptibility0.68407689
115MP0001764_abnormal_homeostasis0.67448471
116MP0002971_abnormal_brown_adipose0.65290960
117MP0004134_abnormal_chest_morphology0.65213794
118MP0005408_hypopigmentation0.63877605
119MP0001440_abnormal_grooming_behavior0.61310576
120MP0000569_abnormal_digit_pigmentation0.59719388
121MP0003795_abnormal_bone_structure0.59059909
122MP0003045_fibrosis0.58410324
123MP0009703_decreased_birth_body0.57558208
124MP0005334_abnormal_fat_pad0.57259988
125MP0001727_abnormal_embryo_implantation0.57258574
126MP0001919_abnormal_reproductive_system0.56355797
127* MP0002118_abnormal_lipid_homeostasis0.56037388
128* MP0009642_abnormal_blood_homeostasis0.55533111
129MP0001186_pigmentation_phenotype0.54041837
130MP0002733_abnormal_thermal_nociception0.53930744
131MP0005452_abnormal_adipose_tissue0.51028473
132MP0006292_abnormal_olfactory_placode0.50446612
133MP0002177_abnormal_outer_ear0.49507101
134MP0002069_abnormal_eating/drinking_beha0.47943717
135MP0004145_abnormal_muscle_electrophysio0.47050664
136MP0005670_abnormal_white_adipose0.46027082
137MP0001731_abnormal_postnatal_growth0.44900881
138MP0005248_abnormal_Harderian_gland0.43841274
139MP0000163_abnormal_cartilage_morphology0.42867591
140MP0002168_other_aberrant_phenotype0.41767582
141MP0002734_abnormal_mechanical_nocicepti0.41620529
142MP0000609_abnormal_liver_physiology0.41022965
143MP0005389_reproductive_system_phenotype0.40796892
144MP0002229_neurodegeneration0.40339816
145MP0002970_abnormal_white_adipose0.39986558
146MP0003634_abnormal_glial_cell0.39768941
147MP0000955_abnormal_spinal_cord0.39733373
148MP0003787_abnormal_imprinting0.39366495
149MP0004085_abnormal_heartbeat0.37958934
150MP0005076_abnormal_cell_differentiation0.37309287

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)8.67458653
2Hypoglycemic seizures (HP:0002173)8.11838146
3Symptomatic seizures (HP:0011145)7.45330688
4Hypoglycemic coma (HP:0001325)7.09514241
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.46305902
6Insulin-resistant diabetes mellitus (HP:0000831)5.32501152
7Hyperglycemia (HP:0003074)5.08053835
8Abnormality of endocrine pancreas physiology (HP:0012093)4.81975662
9Abnormality of the pancreatic islet cells (HP:0006476)4.81975662
10Pancreatic islet-cell hyperplasia (HP:0004510)4.58957933
11Ketoacidosis (HP:0001993)4.45394365
12Abnormal pancreas size (HP:0012094)4.33030247
13Late onset (HP:0003584)4.29564700
14Large for gestational age (HP:0001520)4.26024005
15Generalized aminoaciduria (HP:0002909)4.17741753
16Abnormality of calcium-phosphate metabolism (HP:0100530)4.16359924
17Decreased circulating renin level (HP:0003351)4.10177536
18Urinary glycosaminoglycan excretion (HP:0003541)3.88698035
19Mucopolysacchariduria (HP:0008155)3.88698035
20Hypomagnesemia (HP:0002917)3.78463323
21Dysostosis multiplex (HP:0000943)3.60755452
22Abnormality of polysaccharide metabolism (HP:0011012)3.56713979
23Abnormality of glycosaminoglycan metabolism (HP:0004371)3.56713979
24Abnormality of mucopolysaccharide metabolism (HP:0011020)3.56713979
25Hypokalemia (HP:0002900)3.49242896
26Osteomalacia (HP:0002749)3.44165797
27Abnormality of the intrinsic pathway (HP:0010989)3.42620041
28Enlarged penis (HP:0000040)3.31714778
29Insulin resistance (HP:0000855)3.23720665
30Type I diabetes mellitus (HP:0100651)3.04601447
31Neoplasm of the adrenal cortex (HP:0100641)3.00832347
32Abnormality of magnesium homeostasis (HP:0004921)2.94162840
33Conjugated hyperbilirubinemia (HP:0002908)2.81111792
34Abnormality of aromatic amino acid family metabolism (HP:0004338)2.79738971
35Agitation (HP:0000713)2.77927980
36Prominent metopic ridge (HP:0005487)2.76782589
37Hyperparathyroidism (HP:0000843)2.73118586
38Abnormality of potassium homeostasis (HP:0011042)2.70952394
39Abnormality of renin-angiotensin system (HP:0000847)2.70260077
40Hematochezia (HP:0002573)2.67567596
41Limb hypertonia (HP:0002509)2.63527694
42Unilateral renal agenesis (HP:0000122)2.61538957
43Thoracolumbar scoliosis (HP:0002944)2.57823544
44Ketosis (HP:0001946)2.52527412
45Hyperthyroidism (HP:0000836)2.49191564
46Hyperactive renin-angiotensin system (HP:0000841)2.47431772
47Abnormal protein glycosylation (HP:0012346)2.46863732
48Abnormal glycosylation (HP:0012345)2.46863732
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.46863732
50Abnormal protein N-linked glycosylation (HP:0012347)2.46863732
51Aplasia/Hypoplasia of the fovea (HP:0008060)2.45816945
52Hypoplasia of the fovea (HP:0007750)2.45816945
53Muscular hypotonia of the trunk (HP:0008936)2.45067859
54Abnormal drinking behavior (HP:0030082)2.43891622
55Polydipsia (HP:0001959)2.43891622
56Conjunctival hamartoma (HP:0100780)2.43407286
57Hyperkalemia (HP:0002153)2.41917283
58Hypokinesia (HP:0002375)2.41766786
59Abnormal sex determination (HP:0012244)2.41292416
60Sex reversal (HP:0012245)2.41292416
61Hemiparesis (HP:0001269)2.40013647
62Dysautonomia (HP:0002459)2.39633260
63Hamartoma of the eye (HP:0010568)2.39192311
64Hypothermia (HP:0002045)2.39038927
65Methylmalonic acidemia (HP:0002912)2.37542347
66Abnormality of the fovea (HP:0000493)2.36457148
67Hepatic necrosis (HP:0002605)2.34047088
68Abnormality of the metopic suture (HP:0005556)2.33410091
69Testicular neoplasm (HP:0010788)2.33403007
70EEG with generalized epileptiform discharges (HP:0011198)2.32926818
71Downturned corners of mouth (HP:0002714)2.32706602
72Tongue fasciculations (HP:0001308)2.31580119
73Progressive neurologic deterioration (HP:0002344)2.31465902
74Hypsarrhythmia (HP:0002521)2.30992411
75Abdominal distention (HP:0003270)2.29067685
76Chronic bronchitis (HP:0004469)2.28248438
77Retinal atrophy (HP:0001105)2.25739350
78Gout (HP:0001997)2.24818750
79Exocrine pancreatic insufficiency (HP:0001738)2.24763001
80Epileptiform EEG discharges (HP:0011182)2.21433407
81Thyroiditis (HP:0100646)2.20356359
82Pheochromocytoma (HP:0002666)2.20174013
83Progressive macrocephaly (HP:0004481)2.19991197
84Abnormality of vitamin B metabolism (HP:0004340)2.18664318
85Cortical visual impairment (HP:0100704)2.16896480
86Visual hallucinations (HP:0002367)2.13535940
87Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10170440
88Double outlet right ventricle (HP:0001719)2.09095924
89Congenital malformation of the right heart (HP:0011723)2.09095924
90Type I transferrin isoform profile (HP:0003642)2.07906934
91Protuberant abdomen (HP:0001538)2.03933410
92Hypophosphatemia (HP:0002148)2.03008602
93Tetany (HP:0001281)1.99994530
94Papilledema (HP:0001085)1.98719508
95Hyperphosphaturia (HP:0003109)1.98354864
96Calf muscle hypertrophy (HP:0008981)1.97889348
97Methylmalonic aciduria (HP:0012120)1.96755028
98Acute hepatic failure (HP:0006554)1.96507751
99Intestinal atresia (HP:0011100)1.96473238
100Vacuolated lymphocytes (HP:0001922)1.96105051
101Neoplasm of the adrenal gland (HP:0100631)1.95454125
102Congenital glaucoma (HP:0001087)1.94277526
103Muscle fibrillation (HP:0010546)1.93245927
104Abnormality of the common coagulation pathway (HP:0010990)1.93111844
105Aqueductal stenosis (HP:0002410)1.93111191
106Abnormality of liposaccharide metabolism (HP:0010968)1.91871696
107Abnormality of glycosphingolipid metabolism (HP:0004343)1.91871696
108Abnormality of glycolipid metabolism (HP:0010969)1.91871696
109Abnormal albumin level (HP:0012116)1.91334651
110Hypoalbuminemia (HP:0003073)1.91334651
111Hypokalemic alkalosis (HP:0001949)1.87945533
112Medial flaring of the eyebrow (HP:0010747)1.86772198
113Abnormality of purine metabolism (HP:0004352)1.85416005
114Increased circulating renin level (HP:0000848)1.85379651
115Furrowed tongue (HP:0000221)1.85253054
116Abnormality of urine glucose concentration (HP:0011016)1.85244029
117Glycosuria (HP:0003076)1.85244029
118Nuclear cataract (HP:0100018)1.84873266
119Irregular vertebral endplates (HP:0003301)1.84866396
120Neuroendocrine neoplasm (HP:0100634)1.84700071
121Hypobetalipoproteinemia (HP:0003563)1.83522790
122Hypotension (HP:0002615)1.83107855
123Elevated alkaline phosphatase (HP:0003155)1.82680826
124Diminished movement (HP:0002374)1.80951181
125Hyperphosphatemia (HP:0002905)1.78309152
126Disproportionate short-trunk short stature (HP:0003521)1.78225810
127Villous atrophy (HP:0011473)1.77675603
128Abnormality of small intestinal villus morphology (HP:0011472)1.77675603
129Hypercortisolism (HP:0001578)1.76422576
130Abnormality of alkaline phosphatase activity (HP:0004379)1.75277424
131Dicarboxylic aciduria (HP:0003215)1.75170838
132Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75170838
133Abnormality of chloride homeostasis (HP:0011422)1.74635247
134Glucose intolerance (HP:0000833)1.73712543
135Restlessness (HP:0000711)1.72524145
136Skin nodule (HP:0200036)1.72402609
137Abnormal biliary tract morphology (HP:0012440)1.71097112
138Cystic liver disease (HP:0006706)1.70373918
139Oligomenorrhea (HP:0000876)1.69875705
140Decreased subcutaneous fat (HP:0001002)1.69274658
141Muscle hypertrophy of the lower extremities (HP:0008968)1.69070366
142Macroorchidism (HP:0000053)1.68830998
143Missing ribs (HP:0000921)1.68358966
144Stridor (HP:0010307)1.65522525
145Aplasia/hypoplasia of the uterus (HP:0008684)1.63041377
146Tachypnea (HP:0002789)1.60672233
147Increased CSF protein (HP:0002922)1.60061653
148Abnormality of vitamin metabolism (HP:0100508)1.59508326
149Malnutrition (HP:0004395)1.58786047
150Polyuria (HP:0000103)1.57353830
151Cutaneous melanoma (HP:0012056)1.57053729
152Urethral obstruction (HP:0000796)1.56774233
153Septate vagina (HP:0001153)1.52754238
154Abnormality of the renal cortex (HP:0011035)1.52613772
155Anxiety (HP:0000739)1.49237147
156Asymmetry of the thorax (HP:0001555)1.48582179
157Myoglobinuria (HP:0002913)1.48505061
158Acute necrotizing encephalopathy (HP:0006965)1.46498711
159Small for gestational age (HP:0001518)1.45325122
160Congenital primary aphakia (HP:0007707)1.44659658
161Hepatoblastoma (HP:0002884)1.44570752

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR8.33655102
2PASK6.31807254
3FGFR24.54090837
4MAPK154.03809279
5PRKD33.95194784
6HIPK23.19806311
7TAOK33.18717377
8MAP3K22.90607110
9FRK2.60100432
10FLT32.59593601
11PHKG22.46884034
12PHKG12.46884034
13ERN12.20580459
14MST42.12283980
15NTRK11.96906162
16DAPK21.85633891
17WNK41.83561024
18IRAK31.81652841
19MAP3K41.79234903
20MAP4K21.74734176
21CDC42BPA1.64338824
22SCYL21.59037021
23PDGFRA1.52731560
24CAMKK21.52094173
25GRK11.49830885
26NTRK31.49390656
27EPHA31.45687648
28ADRBK21.45312738
29ACVR1B1.44506446
30MAP2K61.42995637
31STK38L1.40943464
32IRAK11.39337195
33CASK1.35434847
34MAP3K11.29442264
35PRKAA21.28357848
36UHMK11.25444821
37CSNK1G11.24462789
38MET1.23978540
39BRSK21.22827296
40PRKCH1.22562830
41PTK21.22088208
42TNIK1.20232973
43AKT31.19717864
44TRPM71.18407761
45STK241.16747155
46PINK11.16683724
47STK31.15052128
48EIF2AK31.10567730
49PRKD21.08309162
50BCKDK1.05470721
51PTK61.01030165
52TRIB30.95130888
53CSNK1G30.94115963
54OXSR10.92621269
55BRD40.91561698
56PRKCG0.91133946
57ZAK0.89236592
58DYRK1B0.89080949
59MAP2K20.87631462
60PAK30.86874186
61CSNK1G20.85386814
62PLK20.85220768
63NUAK10.81254803
64STK110.81158547
65IRAK20.78154195
66PLK30.75947189
67STK390.75748857
68YES10.74332400
69WNK30.73213571
70MAP2K70.70593921
71NLK0.70558494
72BRAF0.68299667
73MAP3K30.66871168
74BMPR20.66720663
75PRKCE0.66541325
76SIK10.64809687
77TRIM280.64039103
78PTK2B0.63217657
79STK40.62782658
80JAK30.62757021
81CDK30.61693072
82ITK0.61048693
83JAK20.57631532
84PNCK0.55929212
85RET0.55466209
86WNK10.54966184
87FER0.54041126
88PRKAA10.53604939
89STK160.52111502
90ZAP700.50834112
91RPS6KA20.50476837
92BMPR1B0.48696707
93PRKCI0.47724710
94FGFR40.47463585
95IRAK40.47430193
96LIMK10.47309758
97CSNK1A1L0.46869131
98ERBB30.46664528
99BRSK10.46606987
100CAMK2D0.44173366
101GSK3A0.42821990
102TAOK10.41277225
103SGK30.39200297
104PRKACG0.38718626
105JAK10.38666574
106RPS6KB10.38067154
107CSNK1A10.37397589
108PRKD10.35544507
109FGFR30.35292053
110VRK10.34454674
111MAP3K70.34199936
112IGF1R0.34168568
113EIF2AK10.33159634
114NEK60.33047083
115PRKG10.32962762
116TEC0.32700811
117IKBKB0.32683715
118CAMKK10.32456330
119PDGFRB0.32225009
120TESK10.30524661
121CAMK2A0.30277709
122PIK3CG0.29219179
123CDK50.29190008
124PRKDC0.28792424
125PRKACA0.28616087
126BCR0.27712635
127STK380.27427999
128PRKCZ0.27364565
129ROCK10.27025319
130ROCK20.27022819
131MARK20.26772962
132MTOR0.26764351
133CSNK1D0.25810138
134MKNK20.25803994
135SGK10.25783075
136TNK20.25686711
137CAMK1G0.25518020
138MAP3K90.25221086
139MAPK140.24767154
140CHUK0.24353398
141PRKG20.24032045
142CAMK2B0.23816487
143IKBKE0.23256264
144SGK20.22676856
145EPHA20.22056674
146SGK4940.21029736
147SGK2230.21029736
148EPHB10.18423554
149PRKCA0.18394094
150DYRK1A0.18351954
151AKT10.18238999
152MAPK100.17527315
153MAPK30.16004727
154RPS6KA30.15180239
155BTK0.14044615
156LATS10.13098417
157ADRBK10.12764124
158MAPK130.12385198

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.63015847
2Protein export_Homo sapiens_hsa030606.12971410
3Sulfur metabolism_Homo sapiens_hsa009203.69900624
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.37076810
5Insulin secretion_Homo sapiens_hsa049113.23149242
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40935557
7Vitamin B6 metabolism_Homo sapiens_hsa007502.35007065
8Type II diabetes mellitus_Homo sapiens_hsa049302.34807525
9Vibrio cholerae infection_Homo sapiens_hsa051102.08115945
10Type I diabetes mellitus_Homo sapiens_hsa049402.07996025
11Selenocompound metabolism_Homo sapiens_hsa004501.99867651
12N-Glycan biosynthesis_Homo sapiens_hsa005101.83213828
13Cocaine addiction_Homo sapiens_hsa050301.59808926
14Lysosome_Homo sapiens_hsa041421.57132022
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.51416284
16Oxidative phosphorylation_Homo sapiens_hsa001901.48357336
17* Carbohydrate digestion and absorption_Homo sapiens_hsa049731.37666903
18Fatty acid metabolism_Homo sapiens_hsa012121.37536014
19Other glycan degradation_Homo sapiens_hsa005111.36464139
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35249443
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26243423
22Propanoate metabolism_Homo sapiens_hsa006401.18149247
23Peroxisome_Homo sapiens_hsa041461.17494425
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16180303
25Circadian rhythm_Homo sapiens_hsa047101.15192099
26Regulation of autophagy_Homo sapiens_hsa041401.14654333
27Folate biosynthesis_Homo sapiens_hsa007901.13534505
28Amphetamine addiction_Homo sapiens_hsa050311.13266447
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08840317
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08151628
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08124462
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07708227
33Taste transduction_Homo sapiens_hsa047421.07483233
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05741385
35Tryptophan metabolism_Homo sapiens_hsa003801.05083412
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03836074
37Prolactin signaling pathway_Homo sapiens_hsa049170.96232176
38Pancreatic secretion_Homo sapiens_hsa049720.95318059
39ABC transporters_Homo sapiens_hsa020100.93369247
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90636322
41Thyroid hormone synthesis_Homo sapiens_hsa049180.89471535
42beta-Alanine metabolism_Homo sapiens_hsa004100.89239110
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87765580
44Collecting duct acid secretion_Homo sapiens_hsa049660.85651361
45Butanoate metabolism_Homo sapiens_hsa006500.85015008
46Phototransduction_Homo sapiens_hsa047440.82527282
47Ether lipid metabolism_Homo sapiens_hsa005650.82192132
48Mineral absorption_Homo sapiens_hsa049780.81989023
49* Insulin resistance_Homo sapiens_hsa049310.80661956
50Sphingolipid metabolism_Homo sapiens_hsa006000.78995931
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78476095
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77152818
53Dopaminergic synapse_Homo sapiens_hsa047280.73924668
54Long-term potentiation_Homo sapiens_hsa047200.72310911
55* Glucagon signaling pathway_Homo sapiens_hsa049220.70219515
56Synaptic vesicle cycle_Homo sapiens_hsa047210.69430893
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.69388609
58Prion diseases_Homo sapiens_hsa050200.68590908
59Cholinergic synapse_Homo sapiens_hsa047250.66052400
60Salivary secretion_Homo sapiens_hsa049700.63076504
61Serotonergic synapse_Homo sapiens_hsa047260.60510241
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59799421
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58399745
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58366062
65Steroid biosynthesis_Homo sapiens_hsa001000.58277433
66Phenylalanine metabolism_Homo sapiens_hsa003600.58022536
67Circadian entrainment_Homo sapiens_hsa047130.57322973
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57201546
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55376608
70Estrogen signaling pathway_Homo sapiens_hsa049150.54028327
71GABAergic synapse_Homo sapiens_hsa047270.52505410
72Long-term depression_Homo sapiens_hsa047300.52464149
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51694081
74Alcoholism_Homo sapiens_hsa050340.51196718
75Histidine metabolism_Homo sapiens_hsa003400.49893251
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46699616
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45378771
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45013832
79Linoleic acid metabolism_Homo sapiens_hsa005910.44297092
80Cardiac muscle contraction_Homo sapiens_hsa042600.44232802
81Lysine degradation_Homo sapiens_hsa003100.43696741
82Alzheimers disease_Homo sapiens_hsa050100.42066710
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41890174
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40892646
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.38271331
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36679789
87mTOR signaling pathway_Homo sapiens_hsa041500.36416429
88Parkinsons disease_Homo sapiens_hsa050120.35690859
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35420949
90Glutathione metabolism_Homo sapiens_hsa004800.35233198
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34899714
92Fatty acid elongation_Homo sapiens_hsa000620.34799555
93Rheumatoid arthritis_Homo sapiens_hsa053230.33631599
94Antigen processing and presentation_Homo sapiens_hsa046120.33629490
95Retinol metabolism_Homo sapiens_hsa008300.33519738
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33199389
97Fat digestion and absorption_Homo sapiens_hsa049750.32487032
98Prostate cancer_Homo sapiens_hsa052150.31715720
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31619425
100Thyroid cancer_Homo sapiens_hsa052160.31409165
101Tyrosine metabolism_Homo sapiens_hsa003500.30651496
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30391877
103Bile secretion_Homo sapiens_hsa049760.30046994
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29473425
105Chemical carcinogenesis_Homo sapiens_hsa052040.29355442
106* Insulin signaling pathway_Homo sapiens_hsa049100.29275635
107Arachidonic acid metabolism_Homo sapiens_hsa005900.29014417
108Morphine addiction_Homo sapiens_hsa050320.28865757
109Inositol phosphate metabolism_Homo sapiens_hsa005620.28432179
110Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28094812
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26462990
112Fructose and mannose metabolism_Homo sapiens_hsa000510.23895872
113Dorso-ventral axis formation_Homo sapiens_hsa043200.23641163
114Phagosome_Homo sapiens_hsa041450.22644995
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21533844
116Renin secretion_Homo sapiens_hsa049240.20976508
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20118694
118cAMP signaling pathway_Homo sapiens_hsa040240.19221866
119Fatty acid degradation_Homo sapiens_hsa000710.16952184
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15589806
121Protein digestion and absorption_Homo sapiens_hsa049740.13784469
122Legionellosis_Homo sapiens_hsa051340.13767093
123Ovarian steroidogenesis_Homo sapiens_hsa049130.12649691
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.12518464
125Bladder cancer_Homo sapiens_hsa052190.12212267
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.11456844
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.10232385
128Endometrial cancer_Homo sapiens_hsa052130.08703245
129Melanogenesis_Homo sapiens_hsa049160.08325601
130* AMPK signaling pathway_Homo sapiens_hsa041520.07313995
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.06861123
132Glutamatergic synapse_Homo sapiens_hsa047240.04782632
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.04176286
134* Metabolic pathways_Homo sapiens_hsa011000.03241974
135Endocytosis_Homo sapiens_hsa041440.02979888
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.01981367

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