G6PC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the catalytic subunit of glucose-6-phosphatase (G6Pase). G6Pase is located in the endoplasmic reticulum (ER) and catalyzes the hydrolysis of glucose-6-phosphate to glucose and phosphate in the last step of the gluconeogenic and glycogenolytic pathways. Mutations in this gene result in autosomal recessive severe congenital neutropenia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.12234340
2DNA deamination (GO:0045006)6.74471895
3viral transcription (GO:0019083)4.87772039
4SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.80689780
5cotranslational protein targeting to membrane (GO:0006613)4.75211855
6translational termination (GO:0006415)4.69218790
7protein targeting to ER (GO:0045047)4.67776545
8protein localization to endoplasmic reticulum (GO:0070972)4.48284758
9establishment of protein localization to endoplasmic reticulum (GO:0072599)4.45249500
10translational elongation (GO:0006414)4.39145057
11deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.34164854
12protein maturation by protein folding (GO:0022417)4.23898684
13telomere maintenance via semi-conservative replication (GO:0032201)4.19170630
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.17497690
15L-serine metabolic process (GO:0006563)4.07281440
16maturation of SSU-rRNA (GO:0030490)4.03694929
17ribosomal small subunit biogenesis (GO:0042274)4.02102237
18respiratory chain complex IV assembly (GO:0008535)4.00198810
19DNA strand elongation involved in DNA replication (GO:0006271)3.95929014
20establishment of protein localization to mitochondrial membrane (GO:0090151)3.88404128
21pseudouridine synthesis (GO:0001522)3.81287438
22signal peptide processing (GO:0006465)3.76960942
23ATP synthesis coupled proton transport (GO:0015986)3.75990757
24energy coupled proton transport, down electrochemical gradient (GO:0015985)3.75990757
25cellular protein complex disassembly (GO:0043624)3.75065558
26DNA strand elongation (GO:0022616)3.73606571
27oxidative phosphorylation (GO:0006119)3.70798565
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.69242808
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.69242808
30NADH dehydrogenase complex assembly (GO:0010257)3.69242808
31negative regulation of phagocytosis (GO:0050765)3.60941906
32viral life cycle (GO:0019058)3.58082602
33protein complex biogenesis (GO:0070271)3.56027151
34establishment of integrated proviral latency (GO:0075713)3.55636020
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.53656206
36GTP biosynthetic process (GO:0006183)3.48812022
37mitochondrial respiratory chain complex assembly (GO:0033108)3.45505619
38UTP biosynthetic process (GO:0006228)3.45255912
39cytochrome complex assembly (GO:0017004)3.43228610
40quinone biosynthetic process (GO:1901663)3.39589056
41ubiquinone biosynthetic process (GO:0006744)3.39589056
42translational initiation (GO:0006413)3.39269041
43fucose catabolic process (GO:0019317)3.38138114
44L-fucose metabolic process (GO:0042354)3.38138114
45L-fucose catabolic process (GO:0042355)3.38138114
46respiratory electron transport chain (GO:0022904)3.35943320
47telomere maintenance via recombination (GO:0000722)3.32540219
48pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.31379452
49chaperone-mediated protein transport (GO:0072321)3.30771244
50electron transport chain (GO:0022900)3.29593641
51mannosylation (GO:0097502)3.29270372
52protein complex disassembly (GO:0043241)3.28822854
53cullin deneddylation (GO:0010388)3.28179449
54negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.27202804
55platelet dense granule organization (GO:0060155)3.24450607
56antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.22802272
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.22802272
58translation (GO:0006412)3.22130442
59inner mitochondrial membrane organization (GO:0007007)3.19953659
60histone arginine methylation (GO:0034969)3.19617564
61CTP metabolic process (GO:0046036)3.19199615
62CTP biosynthetic process (GO:0006241)3.19199615
63pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.18276447
64protein deneddylation (GO:0000338)3.16884011
65protein targeting to membrane (GO:0006612)3.16762257
66macromolecular complex disassembly (GO:0032984)3.11332610
67iron-sulfur cluster assembly (GO:0016226)3.11006875
68metallo-sulfur cluster assembly (GO:0031163)3.11006875
69L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.10912078
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09074807
71IMP metabolic process (GO:0046040)3.07183815
72peptidyl-arginine omega-N-methylation (GO:0035247)3.06513472
73establishment of viral latency (GO:0019043)3.06281368
74negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.05538672
75negative regulation of ligase activity (GO:0051352)3.05538672
76UTP metabolic process (GO:0046051)3.04673716
77regulation of cellular amino acid metabolic process (GO:0006521)3.01820606
78aerobic respiration (GO:0009060)2.96962361
79purine-containing compound salvage (GO:0043101)2.96061230
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92295314
81transcription elongation from RNA polymerase III promoter (GO:0006385)2.91967330
82termination of RNA polymerase III transcription (GO:0006386)2.91967330
83peptidyl-histidine modification (GO:0018202)2.89863801
84regulation of mitochondrial translation (GO:0070129)2.89861077
85pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.89793748
86telomere maintenance via telomere lengthening (GO:0010833)2.88810342
87positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.88669128
88ubiquinone metabolic process (GO:0006743)2.88514754
89DNA replication initiation (GO:0006270)2.86811293
90neutrophil mediated immunity (GO:0002446)2.86198740
91ribosomal large subunit biogenesis (GO:0042273)2.85647164
92IMP biosynthetic process (GO:0006188)2.85584751
93proteasome assembly (GO:0043248)2.84429978
94heme biosynthetic process (GO:0006783)2.84126858
95cellular response to zinc ion (GO:0071294)2.84108134
96heart contraction (GO:0060047)2.82457000
97heart process (GO:0003015)2.82457000
98formation of translation preinitiation complex (GO:0001731)2.81857301
99protein retention in ER lumen (GO:0006621)2.80675083
100establishment of protein localization to mitochondrion (GO:0072655)2.79375024
101DNA damage response, detection of DNA damage (GO:0042769)2.78905104
102nucleotide-excision repair, DNA gap filling (GO:0006297)2.78584124
103mitotic recombination (GO:0006312)2.78310787
104nuclear envelope reassembly (GO:0031468)2.76152982
105mitotic nuclear envelope reassembly (GO:0007084)2.76152982
106anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.75402919
107tricarboxylic acid cycle (GO:0006099)2.75052357
108DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73470573
109regulation of cellular respiration (GO:0043457)2.73215158
110nuclear-transcribed mRNA catabolic process (GO:0000956)2.72000186
111RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.71991380
112tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.71991380
113spliceosomal snRNP assembly (GO:0000387)2.71854833
114maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.71622241
1152-deoxyribonucleotide biosynthetic process (GO:0009265)2.70116165
116deoxyribose phosphate biosynthetic process (GO:0046385)2.70116165
117protein targeting to mitochondrion (GO:0006626)2.68631243
118signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.67425086
119signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.67425086
120signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.67425086
121nucleobase biosynthetic process (GO:0046112)2.66601977
122intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.65972762
123signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.65972762
124oxygen transport (GO:0015671)2.65853606
125GDP-mannose metabolic process (GO:0019673)2.65454351
126pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.64032123
127modulation of growth of symbiont involved in interaction with host (GO:0044144)2.62557911
128regulation of growth of symbiont in host (GO:0044126)2.62557911
129negative regulation of growth of symbiont in host (GO:0044130)2.62557911
130negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.62557911
131guanosine-containing compound biosynthetic process (GO:1901070)2.62256793
132dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.62175139
133signal transduction involved in DNA damage checkpoint (GO:0072422)2.61613225
134signal transduction involved in DNA integrity checkpoint (GO:0072401)2.61613225
135negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.61476844
136fucose metabolic process (GO:0006004)2.60959980
137purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.60121528
138purine nucleoside triphosphate biosynthetic process (GO:0009145)2.59978930
139ribonucleoside triphosphate biosynthetic process (GO:0009201)2.59809075
140tRNA methylation (GO:0030488)2.59348473
141proline biosynthetic process (GO:0006561)2.59199628
142fucosylation (GO:0036065)2.58377264
143antigen processing and presentation of endogenous antigen (GO:0019883)2.57642257
144cellular component biogenesis (GO:0044085)2.57274575
145signal transduction involved in cell cycle checkpoint (GO:0072395)2.57244118
146protein localization to mitochondrion (GO:0070585)2.57216710
147mRNA catabolic process (GO:0006402)2.55683911
148antigen processing and presentation via MHC class Ib (GO:0002475)2.55330294
149base-excision repair, AP site formation (GO:0006285)2.55059578
150DNA unwinding involved in DNA replication (GO:0006268)2.55038731
151negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.53741044
152regulation of telomerase activity (GO:0051972)2.53553422
153positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.53291812
154branched-chain amino acid catabolic process (GO:0009083)2.52949384
155GMP metabolic process (GO:0046037)2.52109419
156definitive hemopoiesis (GO:0060216)2.51146998
157tRNA aminoacylation for protein translation (GO:0006418)2.49146922
158serine family amino acid biosynthetic process (GO:0009070)2.45521836
159C-terminal protein lipidation (GO:0006501)2.45442109
160amino acid activation (GO:0043038)2.43836692
161tRNA aminoacylation (GO:0043039)2.43836692
162rRNA modification (GO:0000154)2.43562187
163peptidyl-arginine N-methylation (GO:0035246)2.42645742
164peptidyl-arginine methylation (GO:0018216)2.42645742
165water-soluble vitamin biosynthetic process (GO:0042364)2.41433773
166protein neddylation (GO:0045116)2.40868515
167positive regulation of ligase activity (GO:0051351)2.38178000
168nucleoside transmembrane transport (GO:1901642)2.35901747
169regulation of ubiquitin-protein transferase activity (GO:0051438)2.34410279
170nucleoside triphosphate biosynthetic process (GO:0009142)2.34262757
171C-terminal protein amino acid modification (GO:0018410)2.33945992
172aldehyde catabolic process (GO:0046185)2.33719652

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.41459604
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.28122724
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.68712728
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.52037344
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.42420293
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.05770437
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99971180
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.93195770
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.84470209
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.79931400
11SCL_19346495_ChIP-Seq_HPC-7_Human2.77620476
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.74648777
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69984759
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.68524311
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.66585386
16* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.61773717
17TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.56090205
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.48739758
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.39966042
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.35009004
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33314085
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.25950923
23* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.23171103
24GATA1_22025678_ChIP-Seq_K562_Human2.21126848
25VDR_23849224_ChIP-Seq_CD4+_Human2.16955743
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12511933
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11690091
28ERG_20887958_ChIP-Seq_HPC-7_Mouse2.10038987
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.01391072
30VDR_21846776_ChIP-Seq_THP-1_Human2.00939674
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99360549
32* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.96734648
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.96361330
34XRN2_22483619_ChIP-Seq_HELA_Human1.96166785
35FOXP3_21729870_ChIP-Seq_TREG_Human1.92026659
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91520411
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.90698388
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89679622
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.85992357
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.85195476
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82013586
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80481081
43DCP1A_22483619_ChIP-Seq_HELA_Human1.80246406
44* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.79641690
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77334024
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.75682560
47DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.74762453
48GABP_19822575_ChIP-Seq_HepG2_Human1.72018859
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68854606
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65773553
51MYC_22102868_ChIP-Seq_BL_Human1.65067797
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64306765
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64035226
54* SPI1_23547873_ChIP-Seq_NB4_Human1.61441163
55CIITA_25753668_ChIP-Seq_RAJI_Human1.61379950
56* TTF2_22483619_ChIP-Seq_HELA_Human1.58417918
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57606335
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57403187
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57347691
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55829722
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.53378226
62GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.52376005
63IRF8_22096565_ChIP-ChIP_GC-B_Human1.49401635
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47948387
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45659895
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39390268
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39043106
68* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38937919
69* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38911827
70* FOXP1_21924763_ChIP-Seq_HESCs_Human1.38660046
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38280484
72KDM5A_27292631_Chip-Seq_BREAST_Human1.37472437
73VDR_24763502_ChIP-Seq_THP-1_Human1.37341767
74CTCF_18555785_ChIP-Seq_MESCs_Mouse1.36681865
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.36399547
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34565668
77* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34081124
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33579568
79ZNF263_19887448_ChIP-Seq_K562_Human1.33371505
80* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32285213
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31951960
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29838569
83NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28903751
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27581354
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26794888
86CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.26746474
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26718096
88* RUNX1_22412390_ChIP-Seq_EML_Mouse1.24891796
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21930008
90BP1_19119308_ChIP-ChIP_Hs578T_Human1.17317664
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16639208
92FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15998241
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15858324
94SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.13701076
95SOX2_16153702_ChIP-ChIP_HESCs_Human1.13114881
96RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11620600
97STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11311179
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10490933
99SOX2_18692474_ChIP-Seq_MEFs_Mouse1.10450016
100BCL6_27268052_Chip-Seq_Bcells_Human1.10313119
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10042447
102PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09703030
103TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09105160
104MYC_18940864_ChIP-ChIP_HL60_Human1.08561245
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08216102
106PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08008855
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07995761
108ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06930757
109SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06764104
110E2F1_21310950_ChIP-Seq_MCF-7_Human1.06268437
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.06230508
112RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05930613
113NANOG_16153702_ChIP-ChIP_HESCs_Human1.05838504
114NOTCH1_21737748_ChIP-Seq_TLL_Human1.05795946
115FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04341390
116MYB_26560356_Chip-Seq_TH2_Human1.02854542
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02672214
118* ELK1_19687146_ChIP-ChIP_HELA_Human1.02604889
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02557291
120CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02512156
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02046017
122OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00654906
123IRF8_21731497_ChIP-ChIP_J774_Mouse0.99671770
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99630073
125CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98319353
126* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98006818
127* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97830120
128KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97766569
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97620544
130BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97456387
131CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97426433
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97425523
133PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96800439
134STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96753052
135CTCF_26484167_Chip-Seq_Bcells_Mouse0.95953091
136RARB_24833708_ChIP-Seq_LIVER_Mouse0.95854469
137RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95569600
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94649352
139TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93547963
140POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93081786
141TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92770089
142ERG_21242973_ChIP-ChIP_JURKAT_Human0.91013421
143BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90895436
144YY1_22570637_ChIP-Seq_MALME-3M_Human0.89406308
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89323886
146P68_20966046_ChIP-Seq_HELA_Human0.89150807
147TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.88537913
148SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86114489
149* RARA_24833708_ChIP-Seq_LIVER_Mouse0.85948546

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.19447141
2MP0002396_abnormal_hematopoietic_system3.90332427
3MP0003646_muscle_fatigue2.97145942
4MP0005410_abnormal_fertilization2.74374316
5MP0004133_heterotaxia2.58096132
6MP0006036_abnormal_mitochondrial_physio2.52007112
7MP0001545_abnormal_hematopoietic_system2.42730888
8MP0005397_hematopoietic_system_phenotyp2.42730888
9MP0002653_abnormal_ependyma_morphology2.42428958
10MP0001986_abnormal_taste_sensitivity2.29183097
11MP0009379_abnormal_foot_pigmentation2.25806176
12MP0003122_maternal_imprinting2.18997606
13MP0000751_myopathy2.17533656
14MP0003724_increased_susceptibility_to2.17078632
15MP0002254_reproductive_system_inflammat2.15494778
16MP0008789_abnormal_olfactory_epithelium2.13330848
17MP0005174_abnormal_tail_pigmentation2.09430052
18MP0008932_abnormal_embryonic_tissue2.04585436
19MP0002938_white_spotting2.04468795
20MP0006292_abnormal_olfactory_placode2.03115972
21MP0003123_paternal_imprinting1.98838572
22MP0001835_abnormal_antigen_presentation1.96831100
23MP0004808_abnormal_hematopoietic_stem1.94341047
24MP0003136_yellow_coat_color1.92393709
25MP0000749_muscle_degeneration1.87657912
26MP0008057_abnormal_DNA_replication1.87186648
27MP0003172_abnormal_lysosome_physiology1.87181236
28MP0005171_absent_coat_pigmentation1.83786451
29MP0004147_increased_porphyrin_level1.77310500
30MP0005075_abnormal_melanosome_morpholog1.75825644
31MP0003866_abnormal_defecation1.75663427
32MP0003693_abnormal_embryo_hatching1.75354652
33MP0003283_abnormal_digestive_organ1.74931119
34MP0005499_abnormal_olfactory_system1.72039256
35MP0005394_taste/olfaction_phenotype1.72039256
36MP0001853_heart_inflammation1.71426214
37MP0002166_altered_tumor_susceptibility1.70107294
38MP0010094_abnormal_chromosome_stability1.69676059
39MP0000490_abnormal_crypts_of1.68714897
40MP0002148_abnormal_hypersensitivity_rea1.66657172
41MP0006054_spinal_hemorrhage1.66356242
42MP0004215_abnormal_myocardial_fiber1.62465661
43MP0002102_abnormal_ear_morphology1.58560012
44MP0005257_abnormal_intraocular_pressure1.58205494
45MP0004084_abnormal_cardiac_muscle1.58036837
46MP0004858_abnormal_nervous_system1.57564321
47MP0000049_abnormal_middle_ear1.56354436
48MP0002837_dystrophic_cardiac_calcinosis1.55377454
49MP0009785_altered_susceptibility_to1.55355656
50MP0003763_abnormal_thymus_physiology1.53733510
51MP0004272_abnormal_basement_membrane1.53315176
52MP0002095_abnormal_skin_pigmentation1.49024798
53MP0005464_abnormal_platelet_physiology1.47326680
54MP0002398_abnormal_bone_marrow1.46436530
55MP0003121_genomic_imprinting1.46135933
56MP0005671_abnormal_response_to1.45063421
57MP0001905_abnormal_dopamine_level1.45038111
58MP0009333_abnormal_splenocyte_physiolog1.43457049
59MP0003656_abnormal_erythrocyte_physiolo1.43176940
60MP0000343_altered_response_to1.43035312
61MP0002638_abnormal_pupillary_reflex1.42706382
62MP0001529_abnormal_vocalization1.41507432
63MP0000015_abnormal_ear_pigmentation1.40881746
64MP0001293_anophthalmia1.38375414
65* MP0005025_abnormal_response_to1.38192945
66MP0004036_abnormal_muscle_relaxation1.37492607
67MP0010386_abnormal_urinary_bladder1.36154275
68MP0002735_abnormal_chemical_nociception1.35601978
69MP0000465_gastrointestinal_hemorrhage1.34276452
70MP0003119_abnormal_digestive_system1.32882274
71MP0002132_abnormal_respiratory_system1.32660354
72MP0005000_abnormal_immune_tolerance1.32284089
73MP0003942_abnormal_urinary_system1.31053114
74MP0003878_abnormal_ear_physiology1.30796512
75MP0005377_hearing/vestibular/ear_phenot1.30796512
76* MP0002420_abnormal_adaptive_immunity1.29750605
77MP0005330_cardiomyopathy1.27288727
78* MP0002419_abnormal_innate_immunity1.27017433
79MP0002006_tumorigenesis1.26400976
80MP0002163_abnormal_gland_morphology1.25891738
81* MP0001819_abnormal_immune_cell1.25541551
82MP0004957_abnormal_blastocyst_morpholog1.24152691
83MP0003718_maternal_effect1.23498454
84MP0003186_abnormal_redox_activity1.21058531
85MP0001299_abnormal_eye_distance/1.20416311
86MP0003937_abnormal_limbs/digits/tail_de1.19328011
87* MP0000716_abnormal_immune_system1.18177914
88MP0008058_abnormal_DNA_repair1.18119880
89MP0002233_abnormal_nose_morphology1.17904492
90* MP0002429_abnormal_blood_cell1.16465226
91MP0004233_abnormal_muscle_weight1.15216623
92MP0002722_abnormal_immune_system1.14978319
93MP0006035_abnormal_mitochondrial_morpho1.13069275
94MP0005379_endocrine/exocrine_gland_phen1.12892629
95MP0000689_abnormal_spleen_morphology1.11036612
96MP0002751_abnormal_autonomic_nervous1.09573576
97MP0002723_abnormal_immune_serum1.09360603
98MP0003183_abnormal_peptide_metabolism1.08111791
99MP0001984_abnormal_olfaction1.08001786
100MP0003787_abnormal_imprinting1.05894993
101MP0002090_abnormal_vision1.05135637
102MP0001968_abnormal_touch/_nociception1.04398702
103MP0005058_abnormal_lysosome_morphology1.03408239
104MP0006072_abnormal_retinal_apoptosis1.02513294
105MP0008775_abnormal_heart_ventricle1.02426873
106MP0000747_muscle_weakness1.01168123
107MP0001765_abnormal_ion_homeostasis1.00826968
108MP0000372_irregular_coat_pigmentation0.99576702
109MP0002452_abnormal_antigen_presenting0.97830913
110MP0003315_abnormal_perineum_morphology0.97485547
111MP0002111_abnormal_tail_morphology0.97323687
112MP0002085_abnormal_embryonic_tissue0.97318990
113MP0009672_abnormal_birth_weight0.96822648
114MP0003077_abnormal_cell_cycle0.96438064
115MP0001188_hyperpigmentation0.94843710
116MP0002697_abnormal_eye_size0.94396647
117MP0003755_abnormal_palate_morphology0.94384695
118MP0002736_abnormal_nociception_after0.94046926
119MP0002909_abnormal_adrenal_gland0.92086141
120MP0008007_abnormal_cellular_replicative0.90814269
121MP0000685_abnormal_immune_system0.90436164
122MP0000537_abnormal_urethra_morphology0.89591072
123MP0003861_abnormal_nervous_system0.89537833
124MP0004484_altered_response_of0.88555388
125MP0005670_abnormal_white_adipose0.88362524
126MP0001800_abnormal_humoral_immune0.87247084
127MP0005409_darkened_coat_color0.87213301
128MP0002106_abnormal_muscle_physiology0.87138002
129MP0002160_abnormal_reproductive_system0.85739202
130MP0003941_abnormal_skin_development0.85360598
131MP0000778_abnormal_nervous_system0.85187349
132MP0005508_abnormal_skeleton_morphology0.84471008
133MP0001849_ear_inflammation0.84446666
134MP0004145_abnormal_muscle_electrophysio0.84401088
135MP0003786_premature_aging0.84193868
136MP0003111_abnormal_nucleus_morphology0.83967624
137MP0000858_altered_metastatic_potential0.83536597
138MP0000703_abnormal_thymus_morphology0.82781288
139MP0008569_lethality_at_weaning0.82353993
140MP0005551_abnormal_eye_electrophysiolog0.81784895
141MP0003806_abnormal_nucleotide_metabolis0.80463925
142MP0000358_abnormal_cell_content/0.80269252
143MP0010155_abnormal_intestine_physiology0.79704021
144MP0001970_abnormal_pain_threshold0.79657143
145MP0002084_abnormal_developmental_patter0.79544830
146MP0009250_abnormal_appendicular_skeleto0.79495271
147MP0001663_abnormal_digestive_system0.79461323
148MP0005646_abnormal_pituitary_gland0.78833538
149MP0002019_abnormal_tumor_incidence0.78677021
150MP0005367_renal/urinary_system_phenotyp0.78479747
151MP0000516_abnormal_urinary_system0.78479747
152MP0001845_abnormal_inflammatory_respons0.78472900
153MP0003436_decreased_susceptibility_to0.78462575
154MP0002269_muscular_atrophy0.78100913
155MP0001873_stomach_inflammation0.78065930
156MP0000681_abnormal_thyroid_gland0.77556190
157MP0009384_cardiac_valve_regurgitation0.77453608
158MP0006276_abnormal_autonomic_nervous0.77303643
159MP0002405_respiratory_system_inflammati0.76878814
160MP0000026_abnormal_inner_ear0.75297974
161MP0001324_abnormal_eye_pigmentation0.74990872
162MP0000538_abnormal_urinary_bladder0.74054867
163MP0002116_abnormal_craniofacial_bone0.74037074
164MP0001730_embryonic_growth_arrest0.73397353
165MP0002752_abnormal_somatic_nervous0.72968373
166MP0002295_abnormal_pulmonary_circulatio0.71810677
167MP0002234_abnormal_pharynx_morphology0.70446659
168MP0003938_abnormal_ear_development0.69891471
169MP0001485_abnormal_pinna_reflex0.69844226
170MP0000534_abnormal_ureter_morphology0.69836800
171MP0003011_delayed_dark_adaptation0.69670160
172MP0001286_abnormal_eye_development0.69580174
173MP0000631_abnormal_neuroendocrine_gland0.69577901
174MP0000647_abnormal_sebaceous_gland0.69248349
175MP0008438_abnormal_cutaneous_collagen0.69035592
176MP0002557_abnormal_social/conspecific_i0.68945990
177MP0002080_prenatal_lethality0.68909553
178MP0001661_extended_life_span0.68434663
179MP0009053_abnormal_anal_canal0.68427057

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.78596780
2Thrombocytosis (HP:0001894)4.56300311
3* Abnormal number of erythroid precursors (HP:0012131)4.39818329
4Mitochondrial inheritance (HP:0001427)4.35163606
5* Abnormality of cells of the erythroid lineage (HP:0012130)4.31467995
6Hepatocellular necrosis (HP:0001404)4.30994534
7Hepatic necrosis (HP:0002605)4.18980516
8Abnormal mitochondria in muscle tissue (HP:0008316)4.05040340
9Increased hepatocellular lipid droplets (HP:0006565)4.03031596
10Acute necrotizing encephalopathy (HP:0006965)4.02779767
11Increased intramyocellular lipid droplets (HP:0012240)3.92568878
12Increased CSF lactate (HP:0002490)3.92404180
13Lipid accumulation in hepatocytes (HP:0006561)3.81845109
14Type I transferrin isoform profile (HP:0003642)3.77458322
15Increased muscle lipid content (HP:0009058)3.73798567
16Reticulocytopenia (HP:0001896)3.71813379
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.66937968
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.66937968
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.47765671
20Petechiae (HP:0000967)3.45693462
21Renal Fanconi syndrome (HP:0001994)3.43801480
22Abnormal protein glycosylation (HP:0012346)3.31204900
23Abnormal glycosylation (HP:0012345)3.31204900
24Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.31204900
25Abnormal protein N-linked glycosylation (HP:0012347)3.31204900
26Acute encephalopathy (HP:0006846)3.29413515
27Progressive macrocephaly (HP:0004481)3.23990146
28Reduced antithrombin III activity (HP:0001976)3.20073140
29Exertional dyspnea (HP:0002875)3.13442640
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.11398450
31Elevated erythrocyte sedimentation rate (HP:0003565)3.10363338
32Abnormality of the heme biosynthetic pathway (HP:0010472)3.09309862
33Exercise intolerance (HP:0003546)3.00472081
34Respiratory difficulties (HP:0002880)2.98576837
35Pallor (HP:0000980)2.88941444
36Lactic acidosis (HP:0003128)2.88908743
37Increased serum lactate (HP:0002151)2.86011185
38Generalized aminoaciduria (HP:0002909)2.76055174
39IgM deficiency (HP:0002850)2.75154327
40Abnormality of renal resorption (HP:0011038)2.64172583
41Colon cancer (HP:0003003)2.63683742
42Chronic otitis media (HP:0000389)2.62880209
4311 pairs of ribs (HP:0000878)2.62528119
44Respiratory failure (HP:0002878)2.56129185
45Severe visual impairment (HP:0001141)2.55873563
46Abnormality of glycolysis (HP:0004366)2.55756316
47Hyperglycinemia (HP:0002154)2.47039906
48Pancytopenia (HP:0001876)2.42992497
49Nasal polyposis (HP:0100582)2.38646948
50Increased serum pyruvate (HP:0003542)2.35953035
51Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35503767
52Macrocytic anemia (HP:0001972)2.35129912
53Type 2 muscle fiber atrophy (HP:0003554)2.28784735
54Muscle fiber atrophy (HP:0100295)2.19250962
55Oral leukoplakia (HP:0002745)2.19005345
56Papilledema (HP:0001085)2.18943941
57Abnormality of the labia minora (HP:0012880)2.17218281
58Abnormality of the nasal mucosa (HP:0000433)2.17060602
59Prolonged bleeding time (HP:0003010)2.16747568
60Sclerocornea (HP:0000647)2.15442285
61Myositis (HP:0100614)2.14516619
62Recurrent bronchitis (HP:0002837)2.14433738
63Absent rod-and cone-mediated responses on ERG (HP:0007688)2.11558747
64Opisthotonus (HP:0002179)2.09435740
65Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.08424273
66Absent epiphyses (HP:0010577)2.08424273
67Hyperglycinuria (HP:0003108)2.07506031
68Pulmonary fibrosis (HP:0002206)2.06909591
69Emotional lability (HP:0000712)2.05235187
70Testicular atrophy (HP:0000029)2.03560275
71Horseshoe kidney (HP:0000085)2.00663071
72Methylmalonic aciduria (HP:0012120)2.00388456
73Anophthalmia (HP:0000528)1.99402596
74Hypokinesia (HP:0002375)1.98905859
75Occipital encephalocele (HP:0002085)1.98057003
76Abnormal number of incisors (HP:0011064)1.96996901
77Microvesicular hepatic steatosis (HP:0001414)1.95730703
78Ragged-red muscle fibers (HP:0003200)1.95447192
79Neoplasm of head and neck (HP:0012288)1.94820568
80Esophageal neoplasm (HP:0100751)1.94820568
81Optic disc pallor (HP:0000543)1.94359978
82Abnormality of glycine metabolism (HP:0010895)1.92416907
83Abnormality of serine family amino acid metabolism (HP:0010894)1.92416907
84Retinal dysplasia (HP:0007973)1.90613213
85Abnormality of dentin (HP:0010299)1.89588973
86Abnormality of T cell physiology (HP:0011840)1.88698141
87True hermaphroditism (HP:0010459)1.87623412
88Abnormality of midbrain morphology (HP:0002418)1.87287625
89Molar tooth sign on MRI (HP:0002419)1.87287625
90Adrenal hypoplasia (HP:0000835)1.87149896
91Impaired platelet aggregation (HP:0003540)1.86376671
92Abnormal platelet function (HP:0011869)1.86376671
93Cerebral hypomyelination (HP:0006808)1.85651472
94Broad distal phalanx of finger (HP:0009836)1.85591714
95Increased neuronal autofluorescent lipopigment (HP:0002074)1.85023130
96Progressive muscle weakness (HP:0003323)1.84872042
97Rib fusion (HP:0000902)1.83657543
98Preaxial hand polydactyly (HP:0001177)1.83262454
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82982086
100Pancreatic fibrosis (HP:0100732)1.81027791
101Myoglobinuria (HP:0002913)1.79761774
102Microretrognathia (HP:0000308)1.79225860
103Patent foramen ovale (HP:0001655)1.77872954
104Nonprogressive disorder (HP:0003680)1.76779492
105Pendular nystagmus (HP:0012043)1.76610824
106Optic nerve coloboma (HP:0000588)1.76208030
107Postnatal microcephaly (HP:0005484)1.75657588
108Rhabdomyolysis (HP:0003201)1.75522039
109Hand muscle atrophy (HP:0009130)1.75185459
110Polyphagia (HP:0002591)1.74813188
111Abnormality of urine glucose concentration (HP:0011016)1.74391651
112Glycosuria (HP:0003076)1.74391651
113Medial flaring of the eyebrow (HP:0010747)1.73794721
114Septo-optic dysplasia (HP:0100842)1.72249382
115Chest pain (HP:0100749)1.71071260
116* Neutropenia (HP:0001875)1.70966621
117Degeneration of anterior horn cells (HP:0002398)1.70516156
118Abnormality of the anterior horn cell (HP:0006802)1.70516156
119Absent/shortened dynein arms (HP:0200106)1.69400966
120Dynein arm defect of respiratory motile cilia (HP:0012255)1.69400966
1213-Methylglutaconic aciduria (HP:0003535)1.69394828
122Lethargy (HP:0001254)1.69302598
123Anencephaly (HP:0002323)1.68711443
124Severe muscular hypotonia (HP:0006829)1.68245661
125Leukodystrophy (HP:0002415)1.67714281
126Congenital primary aphakia (HP:0007707)1.66283418
127Acute lymphatic leukemia (HP:0006721)1.65872459
128Gait imbalance (HP:0002141)1.65660139
129Bifid tongue (HP:0010297)1.64275720
130Aplasia/Hypoplasia of the sacrum (HP:0008517)1.62219314
131Facial cleft (HP:0002006)1.61542919
132Neuroendocrine neoplasm (HP:0100634)1.61211662
133Premature rupture of membranes (HP:0001788)1.61037424
134Abnormality of alanine metabolism (HP:0010916)1.60551538
135Hyperalaninemia (HP:0003348)1.60551538
136Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.60551538
137Hypoplastic pelvis (HP:0008839)1.60441668
138Abnormal respiratory motile cilium morphology (HP:0005938)1.60160012
139Abnormal respiratory epithelium morphology (HP:0012253)1.60160012
140Neoplasm of the adrenal cortex (HP:0100641)1.60122364
141Cerebral edema (HP:0002181)1.60001194
142CNS hypomyelination (HP:0003429)1.59878507
143Abnormality of abdominal situs (HP:0011620)1.59623987
144Abdominal situs inversus (HP:0003363)1.59623987
145Palpitations (HP:0001962)1.59589300
146Poor head control (HP:0002421)1.59419801
147Bronchitis (HP:0012387)1.58892501
148CNS demyelination (HP:0007305)1.57729984
149Neoplasm of the adrenal gland (HP:0100631)1.57446837
150Mesangial abnormality (HP:0001966)1.57181153
151Exercise-induced muscle cramps (HP:0003710)1.57122738
152Hypoplasia of the uterus (HP:0000013)1.56510158
153Cholecystitis (HP:0001082)1.56481813
154Abnormal gallbladder physiology (HP:0012438)1.56481813
155Gliosis (HP:0002171)1.56363909
156Poor suck (HP:0002033)1.55392139
157Nephrogenic diabetes insipidus (HP:0009806)1.54958368
158Myotonia (HP:0002486)1.54266680
159Vacuolated lymphocytes (HP:0001922)1.53656118
160Poikiloderma (HP:0001029)1.53545206
161Premature graying of hair (HP:0002216)1.53439798
162Broad foot (HP:0001769)1.51445005
163Prolonged neonatal jaundice (HP:0006579)1.50576153
164Absent thumb (HP:0009777)1.49603373

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.09557261
2MAP3K124.12147647
3STK164.07006073
4NME23.28729867
5PIM23.09959021
6CCNB12.98075117
7LIMK12.67778544
8EIF2AK32.36731908
9CDK192.33373835
10VRK12.32594309
11MAP2K32.32352599
12TEC2.14392494
13TNIK2.07657762
14MYLK2.06955557
15SCYL21.97180031
16MUSK1.96873338
17CSNK1G31.89482274
18EPHA21.87643560
19WEE11.84965902
20DYRK21.77209289
21MAP4K11.76776730
22TSSK61.75718865
23PBK1.72489360
24PDK21.71229599
25KIT1.64064183
26PDK41.62783765
27PDK31.62783765
28BTK1.58522316
29CSNK1A1L1.58495611
30CSNK1G11.55624719
31CAMKK21.54456003
32MAPKAPK51.53149274
33CSNK1G21.50552067
34DAPK11.47966443
35SMG11.47663557
36TESK11.43901155
37PAK41.42214434
38ZAK1.41262144
39IRAK41.39551772
40TTK1.38593615
41TRIM281.34706949
42TAF11.34204004
43EIF2AK11.33866024
44MAP3K111.33426159
45DYRK31.28033977
46MAP4K21.27308365
47PLK31.26757657
48MAP3K61.25750513
49ZAP701.25463324
50SRPK11.22859944
51ERN11.21502461
52NME11.21028267
53FES1.19619460
54EPHB21.14288800
55AURKA1.12444990
56PLK11.10720097
57LRRK21.08783554
58MATK1.08135991
59NUAK11.05345211
60EEF2K1.04702002
61NEK11.04288555
62GRK11.03893474
63CHEK21.03735917
64SYK1.02973014
65PASK0.99994597
66PRKD30.98715005
67BUB10.98278095
68BRSK20.97168898
69WNK30.94157891
70MAP2K60.93434794
71PRKCI0.90500752
72TLK10.90433073
73BCKDK0.90144733
74CAMK1D0.90054864
75PTK20.89765481
76MAP3K50.88644572
77CDC70.86898726
78BLK0.86447598
79ARAF0.86039699
80TGFBR10.85777461
81LMTK20.84220679
82KDR0.83124790
83ILK0.82736310
84DAPK30.82688785
85FLT30.81861907
86NTRK10.80168042
87CDK80.80094119
88SIK30.78952856
89ADRBK20.77994287
90ERBB40.76891467
91IRAK30.76458639
92TNK20.75862508
93CAMK10.75391869
94MKNK10.74670280
95ATR0.70429051
96MAP2K70.70260874
97AURKB0.66928670
98TIE10.65828244
99ICK0.64209375
100PRKG20.63988753
101CASK0.63810961
102MINK10.62720189
103TAOK30.62520348
104BRSK10.62308647
105JAK30.62041137
106OBSCN0.60514584
107TBK10.59245827
108MAPKAPK30.58873312
109MKNK20.58681598
110MAPK40.58527704
111RPS6KA60.58292711
112PAK10.56505201
113CLK10.56315555
114RIPK40.56111201
115EPHA40.55888182
116BRAF0.55115894
117PLK20.54676535
118NEK20.53873829
119PRKCG0.53557844
120AKT20.52899597
121TAOK20.52837858
122ACVR1B0.52031118
123CSNK2A10.51616638
124BMPR1B0.51052938
125BRD40.50289393
126CDK140.49679349
127RPS6KB20.49266246
128CDK11A0.48650504
129CSF1R0.47377508
130PHKG20.46742390
131PHKG10.46742390
132CDK180.45723995
133MAP3K10.45541777
134ABL20.45519974
135CDK150.45140459
136LYN0.45047177
137CAMKK10.44671777
138BMX0.44640510
139MST40.44006949
140CHEK10.43914074
141PINK10.43400739
142RPS6KB10.43048976
143CSNK1A10.43002104
144CAMK1G0.42419857
145RPS6KL10.42336688
146RPS6KC10.42336688
147YES10.41002661
148PLK40.39550123
149HIPK20.38839766
150TESK20.38623727
151TAOK10.38379756
152RPS6KA50.38170277
153CDK70.38128426
154MET0.38049391
155CSNK2A20.37623314
156PRKD20.37029431
157TXK0.36828397
158CAMK2D0.35575032
159UHMK10.35445344
160WNK40.33846828

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.54370069
2DNA replication_Homo sapiens_hsa030304.52831174
3Oxidative phosphorylation_Homo sapiens_hsa001903.24625386
4Parkinsons disease_Homo sapiens_hsa050123.17147967
5Protein export_Homo sapiens_hsa030603.08000828
6Mismatch repair_Homo sapiens_hsa034302.89533473
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.75846231
8Base excision repair_Homo sapiens_hsa034102.63589365
9N-Glycan biosynthesis_Homo sapiens_hsa005102.35845468
10Proteasome_Homo sapiens_hsa030502.33778002
11Homologous recombination_Homo sapiens_hsa034402.29916112
12Huntingtons disease_Homo sapiens_hsa050162.28571243
13Pyrimidine metabolism_Homo sapiens_hsa002402.28512502
14Alzheimers disease_Homo sapiens_hsa050102.16414096
15RNA polymerase_Homo sapiens_hsa030202.15585301
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.80879449
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76880407
18Cardiac muscle contraction_Homo sapiens_hsa042601.70154493
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64677396
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63376107
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63291217
22Steroid biosynthesis_Homo sapiens_hsa001001.62974255
23Nucleotide excision repair_Homo sapiens_hsa034201.57862152
24Pentose phosphate pathway_Homo sapiens_hsa000301.55927441
25Purine metabolism_Homo sapiens_hsa002301.55736497
26Spliceosome_Homo sapiens_hsa030401.51550575
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46420780
28Other glycan degradation_Homo sapiens_hsa005111.42154616
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.41862832
30Vitamin B6 metabolism_Homo sapiens_hsa007501.30991174
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30360060
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28123601
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23242140
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.18811438
35Selenocompound metabolism_Homo sapiens_hsa004501.13891261
36Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.13050925
37Basal cell carcinoma_Homo sapiens_hsa052171.12438494
38Fatty acid metabolism_Homo sapiens_hsa012121.09122624
39Arginine and proline metabolism_Homo sapiens_hsa003301.07770589
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07513927
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06278937
42RNA degradation_Homo sapiens_hsa030181.03648614
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01222546
44Sulfur metabolism_Homo sapiens_hsa009200.97555079
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94429329
46RNA transport_Homo sapiens_hsa030130.93045542
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90744917
48Carbon metabolism_Homo sapiens_hsa012000.89958829
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89441969
50Sulfur relay system_Homo sapiens_hsa041220.88866917
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88413917
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85707627
53Fanconi anemia pathway_Homo sapiens_hsa034600.82653364
54Legionellosis_Homo sapiens_hsa051340.81317365
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81020823
56Renin-angiotensin system_Homo sapiens_hsa046140.78959125
57Peroxisome_Homo sapiens_hsa041460.78167592
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77693598
59Antigen processing and presentation_Homo sapiens_hsa046120.75683017
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74337331
61Vibrio cholerae infection_Homo sapiens_hsa051100.72331115
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70722806
63Cell cycle_Homo sapiens_hsa041100.69275947
64Basal transcription factors_Homo sapiens_hsa030220.68735675
65beta-Alanine metabolism_Homo sapiens_hsa004100.67799081
66Hedgehog signaling pathway_Homo sapiens_hsa043400.67649227
67Fructose and mannose metabolism_Homo sapiens_hsa000510.66410269
68Hippo signaling pathway_Homo sapiens_hsa043900.65483168
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.63088029
70Butanoate metabolism_Homo sapiens_hsa006500.62655619
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62393733
72Hematopoietic cell lineage_Homo sapiens_hsa046400.61883486
73Leishmaniasis_Homo sapiens_hsa051400.61003286
74* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60938637
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.60307259
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58570771
77Non-homologous end-joining_Homo sapiens_hsa034500.57351771
78Tyrosine metabolism_Homo sapiens_hsa003500.56155369
79Collecting duct acid secretion_Homo sapiens_hsa049660.55469378
80Thyroid cancer_Homo sapiens_hsa052160.55129960
81* Metabolic pathways_Homo sapiens_hsa011000.54668352
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52101340
83p53 signaling pathway_Homo sapiens_hsa041150.50529665
84Pyruvate metabolism_Homo sapiens_hsa006200.49103082
85Tryptophan metabolism_Homo sapiens_hsa003800.48679327
86Propanoate metabolism_Homo sapiens_hsa006400.48522756
87Asthma_Homo sapiens_hsa053100.47640824
88* Galactose metabolism_Homo sapiens_hsa000520.47148930
89Folate biosynthesis_Homo sapiens_hsa007900.45463115
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43531553
91Synaptic vesicle cycle_Homo sapiens_hsa047210.42854002
92Epstein-Barr virus infection_Homo sapiens_hsa051690.42132355
93Lysosome_Homo sapiens_hsa041420.41969900
94Glutathione metabolism_Homo sapiens_hsa004800.41898082
95Lysine degradation_Homo sapiens_hsa003100.41839041
96Phototransduction_Homo sapiens_hsa047440.41752045
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41227783
98Fatty acid degradation_Homo sapiens_hsa000710.40400141
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40055696
100Biosynthesis of amino acids_Homo sapiens_hsa012300.38708206
101Olfactory transduction_Homo sapiens_hsa047400.38122807
102Phenylalanine metabolism_Homo sapiens_hsa003600.38054207
103Phagosome_Homo sapiens_hsa041450.37454118
104Platelet activation_Homo sapiens_hsa046110.37268477
105Salmonella infection_Homo sapiens_hsa051320.36833125
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35938145
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35601273
108Shigellosis_Homo sapiens_hsa051310.35240009
109Measles_Homo sapiens_hsa051620.34393708
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33547791
111Primary immunodeficiency_Homo sapiens_hsa053400.33455563
112Vitamin digestion and absorption_Homo sapiens_hsa049770.32608143
113Arginine biosynthesis_Homo sapiens_hsa002200.31491544
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.31487088
115Thyroid hormone synthesis_Homo sapiens_hsa049180.30812240
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30729549
117Herpes simplex infection_Homo sapiens_hsa051680.30640516
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30582051
119Fat digestion and absorption_Homo sapiens_hsa049750.30470451
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30063390
121Sphingolipid metabolism_Homo sapiens_hsa006000.29877854
122mRNA surveillance pathway_Homo sapiens_hsa030150.29606948
123Fatty acid elongation_Homo sapiens_hsa000620.29574342
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28441006
125Gastric acid secretion_Homo sapiens_hsa049710.28195449
126Insulin secretion_Homo sapiens_hsa049110.27391926
127Wnt signaling pathway_Homo sapiens_hsa043100.27252356
128Acute myeloid leukemia_Homo sapiens_hsa052210.25662186
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24875950
130Calcium signaling pathway_Homo sapiens_hsa040200.24132398
131Apoptosis_Homo sapiens_hsa042100.23824759
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23098797
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.22816520
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22699902
135One carbon pool by folate_Homo sapiens_hsa006700.21717173
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.21068683
137Tuberculosis_Homo sapiens_hsa051520.21035456
138Pertussis_Homo sapiens_hsa051330.20869001
139Circadian entrainment_Homo sapiens_hsa047130.20865076

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