G6PD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)5.19537134
2polyketide metabolic process (GO:0030638)5.19537134
3doxorubicin metabolic process (GO:0044598)5.19537134
4positive regulation of Cdc42 GTPase activity (GO:0043089)4.74134025
5Golgi transport vesicle coating (GO:0048200)4.70533192
6COPI coating of Golgi vesicle (GO:0048205)4.70533192
7aminoglycoside antibiotic metabolic process (GO:0030647)4.53338902
8positive regulation of keratinocyte differentiation (GO:0045618)4.42890685
9hepatocyte apoptotic process (GO:0097284)4.25459433
10* pentose-phosphate shunt (GO:0006098)4.20208948
11negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.11183298
12negative regulation of cell size (GO:0045792)3.84760060
13protein localization to endosome (GO:0036010)3.77189384
14* NADPH regeneration (GO:0006740)3.70173145
15* glucose catabolic process (GO:0006007)3.68395304
16regulation of early endosome to late endosome transport (GO:2000641)3.57813747
17regulation of mammary gland epithelial cell proliferation (GO:0033599)3.42375741
18activation of Rac GTPase activity (GO:0032863)3.39558240
19cell-substrate adherens junction assembly (GO:0007045)3.31106708
20focal adhesion assembly (GO:0048041)3.31106708
21response to peptidoglycan (GO:0032494)3.29693897
22maternal placenta development (GO:0001893)3.26552842
23protein retention in ER lumen (GO:0006621)3.23393554
24epithelial cell-cell adhesion (GO:0090136)3.17007697
25semaphorin-plexin signaling pathway (GO:0071526)3.16096258
26positive regulation of epidermal cell differentiation (GO:0045606)3.15895170
27adherens junction assembly (GO:0034333)3.14081174
28branching involved in mammary gland duct morphogenesis (GO:0060444)3.13201986
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.12922016
30retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.12804399
31apoptotic process involved in morphogenesis (GO:0060561)2.94387666
32desmosome organization (GO:0002934)2.91214744
33positive regulation of blood vessel endothelial cell migration (GO:0043536)2.88207359
34dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.86988743
35proline biosynthetic process (GO:0006561)2.84468129
36pinocytosis (GO:0006907)2.84299697
37glycoside metabolic process (GO:0016137)2.84111823
38primary alcohol catabolic process (GO:0034310)2.82672334
39cell-substrate junction assembly (GO:0007044)2.80813241
40regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.78909768
41stress fiber assembly (GO:0043149)2.78753835
42barbed-end actin filament capping (GO:0051016)2.78465360
43amyloid precursor protein catabolic process (GO:0042987)2.76299905
44modulation by symbiont of host cellular process (GO:0044068)2.76145876
45vagina development (GO:0060068)2.74760911
46nucleobase-containing small molecule interconversion (GO:0015949)2.74174157
47epithelial cell differentiation involved in prostate gland development (GO:0060742)2.74162251
48regulation of histone H3-K27 methylation (GO:0061085)2.73683550
49embryonic process involved in female pregnancy (GO:0060136)2.71752503
50response to laminar fluid shear stress (GO:0034616)2.69810802
51regulation of defense response to virus by virus (GO:0050690)2.69362275
52endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.68972286
53* glucose 6-phosphate metabolic process (GO:0051156)2.68596186
54regulation of glucose import in response to insulin stimulus (GO:2001273)2.68503831
55negative regulation of focal adhesion assembly (GO:0051895)2.68264308
56negative regulation of cell junction assembly (GO:1901889)2.68264308
57negative regulation of adherens junction organization (GO:1903392)2.68264308
58positive regulation of extracellular matrix organization (GO:1903055)2.66662361
59regulation of apoptotic process involved in morphogenesis (GO:1902337)2.65546285
60intracellular estrogen receptor signaling pathway (GO:0030520)2.65066128
61negative regulation of fatty acid transport (GO:2000192)2.63831522
62negative regulation of viral release from host cell (GO:1902187)2.62765341
63* pentose metabolic process (GO:0019321)2.62440875
64regulation of endothelial cell chemotaxis (GO:2001026)2.61882039
65modulation by virus of host morphology or physiology (GO:0019048)2.61698173
66signal complex assembly (GO:0007172)2.59056118
67embryonic eye morphogenesis (GO:0048048)2.57437064
68negative regulation of erythrocyte differentiation (GO:0045647)2.56177198
69positive regulation of endothelial cell apoptotic process (GO:2000353)2.55142252
70ear development (GO:0043583)2.54559491
71mannose metabolic process (GO:0006013)2.54102609
72membrane raft organization (GO:0031579)2.53805618
73lipopolysaccharide-mediated signaling pathway (GO:0031663)2.53483214
74skin morphogenesis (GO:0043589)2.52806745
75modulation by virus of host process (GO:0019054)2.52797808
76positive regulation of epidermis development (GO:0045684)2.47412626
77cell differentiation involved in embryonic placenta development (GO:0060706)2.47020393
78basement membrane organization (GO:0071711)2.46269320
79positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.45709560
80activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.45612986
81hyaluronan catabolic process (GO:0030214)2.45430742
82mammary gland epithelial cell proliferation (GO:0033598)2.45105168
83positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.44713058
84spliceosomal tri-snRNP complex assembly (GO:0000244)2.43288341
85protein maturation by protein folding (GO:0022417)2.43092825
86response to water (GO:0009415)2.40823175
87peptidyl-arginine omega-N-methylation (GO:0035247)2.39986749
88positive regulation of histone deacetylation (GO:0031065)2.38864647
89nuclear envelope reassembly (GO:0031468)2.38837424
90mitotic nuclear envelope reassembly (GO:0007084)2.38837424
91positive regulation of receptor recycling (GO:0001921)2.37594111
92regulation of integrin activation (GO:0033623)2.35503023
93positive regulation of nuclease activity (GO:0032075)2.35047062
94positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.34198484
95positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.34034817
96positive regulation by symbiont of host defense response (GO:0052509)2.33346356
97modulation by symbiont of host defense response (GO:0052031)2.33346356
98modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.33346356
99positive regulation by organism of defense response of other organism involved in symbiotic interact2.33346356
100modulation by symbiont of host immune response (GO:0052553)2.33346356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.68369572
2ESR2_21235772_ChIP-Seq_MCF-7_Human2.56706587
3NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.50333919
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46116073
5* RACK7_27058665_Chip-Seq_MCF-7_Human2.45279270
6ELK3_25401928_ChIP-Seq_HUVEC_Human2.44502781
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.44316072
8ZNF263_19887448_ChIP-Seq_K562_Human2.41996165
9MYC_22102868_ChIP-Seq_BL_Human2.38364676
10VDR_21846776_ChIP-Seq_THP-1_Human2.38242549
11LXR_22292898_ChIP-Seq_THP-1_Human2.30790859
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26307398
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.15661204
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.14110016
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.09886895
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04722255
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.98021125
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96180270
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94827181
20KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87793945
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86291301
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.84671665
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.82473820
24TCF7_22412390_ChIP-Seq_EML_Mouse1.79053031
25KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.67360799
26KDM2B_26808549_Chip-Seq_DND41_Human1.66534654
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59806056
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.57474204
29E2F7_22180533_ChIP-Seq_HELA_Human1.55968482
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52179049
31ATF3_27146783_Chip-Seq_COLON_Human1.51302943
32RUNX1_27514584_Chip-Seq_MCF-7_Human1.50061652
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49518186
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48813107
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47490834
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46675634
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45917449
38VDR_24763502_ChIP-Seq_THP-1_Human1.44722339
39KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42022550
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41464136
41KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38884796
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.36018658
43KDM2B_26808549_Chip-Seq_K562_Human1.35669572
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33573795
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31264437
46P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29507826
47TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29354597
48HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29235885
49CLOCK_20551151_ChIP-Seq_293T_Human1.28255296
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27059855
51P68_20966046_ChIP-Seq_HELA_Human1.26959479
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26793168
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.26357734
54MAF_26560356_Chip-Seq_TH1_Human1.26050140
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26012344
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25927100
57NCOR1_26117541_ChIP-Seq_K562_Human1.24107119
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23905599
59* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23290678
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23282915
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21453718
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21290198
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20129319
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19738599
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17624844
66NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17607657
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15551083
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14196292
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14036048
70TP53_22127205_ChIP-Seq_IMR90_Human1.12648760
71SMC4_20622854_ChIP-Seq_HELA_Human1.12172555
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11455054
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11249427
74CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11201171
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.10368010
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.10168518
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09119531
78SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08848363
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.07553474
80MYC_18555785_ChIP-Seq_MESCs_Mouse1.07409891
81UTX_26944678_Chip-Seq_JUKART_Human1.07407508
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07273625
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07200724
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.05932360
85CREB1_26743006_Chip-Seq_LNCaP_Human1.05775003
86MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05529152
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04844750
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04260522
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03952580
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02177701
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99811533
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99325589
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98828798
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98761245
95MAF_26560356_Chip-Seq_TH2_Human0.98753138
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97955804
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96978634
98TFEB_21752829_ChIP-Seq_HELA_Human0.96643029
99SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96505425
100SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96505425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.78005404
2MP0005058_abnormal_lysosome_morphology3.23714815
3MP0005451_abnormal_body_composition3.15074098
4MP0002877_abnormal_melanocyte_morpholog2.97717844
5MP0005076_abnormal_cell_differentiation2.96774530
6MP0003191_abnormal_cellular_cholesterol2.79991033
7MP0003566_abnormal_cell_adhesion2.59165763
8MP0008260_abnormal_autophagy2.58271782
9MP0002796_impaired_skin_barrier2.41754963
10MP0008438_abnormal_cutaneous_collagen2.37277006
11MP0010234_abnormal_vibrissa_follicle2.33253950
12MP0009840_abnormal_foam_cell2.23735895
13MP0004233_abnormal_muscle_weight2.15769982
14MP0003436_decreased_susceptibility_to2.04908627
15MP0004185_abnormal_adipocyte_glucose2.04648344
16MP0001849_ear_inflammation2.03598139
17MP0003172_abnormal_lysosome_physiology2.02992540
18MP0003453_abnormal_keratinocyte_physiol2.02867769
19MP0000858_altered_metastatic_potential1.88112856
20MP0005501_abnormal_skin_physiology1.86724521
21MP0009278_abnormal_bone_marrow1.70143183
22MP0004858_abnormal_nervous_system1.68791476
23MP0004947_skin_inflammation1.55135617
24MP0003300_gastrointestinal_ulcer1.47899352
25MP0002060_abnormal_skin_morphology1.44367566
26MP0000750_abnormal_muscle_regeneration1.42387847
27MP0004264_abnormal_extraembryonic_tissu1.40925741
28MP0003091_abnormal_cell_migration1.37636077
29MP0001348_abnormal_lacrimal_gland1.36915256
30MP0005257_abnormal_intraocular_pressure1.34893038
31MP0005023_abnormal_wound_healing1.30904898
32MP0000678_abnormal_parathyroid_gland1.27645632
33MP0001873_stomach_inflammation1.24194494
34MP0009333_abnormal_splenocyte_physiolog1.18891929
35MP0002089_abnormal_postnatal_growth/wei1.16789232
36MP0001216_abnormal_epidermal_layer1.15018327
37MP0000462_abnormal_digestive_system1.14653962
38MP0005464_abnormal_platelet_physiology1.14534848
39MP0004272_abnormal_basement_membrane1.14202948
40MP0005083_abnormal_biliary_tract1.13648948
41MP0001533_abnormal_skeleton_physiology1.13518420
42MP0003806_abnormal_nucleotide_metabolis1.13303714
43MP0005409_darkened_coat_color1.11366303
44MP0003123_paternal_imprinting1.11062574
45MP0004381_abnormal_hair_follicle1.08948513
46MP0002098_abnormal_vibrissa_morphology1.04188127
47MP0002998_abnormal_bone_remodeling1.03703079
48MP0003303_peritoneal_inflammation1.01610098
49MP0004808_abnormal_hematopoietic_stem1.01567640
50MP0005621_abnormal_cell_physiology1.01336091
51MP0002419_abnormal_innate_immunity1.00362150
52MP0001853_heart_inflammation0.98676637
53MP0004782_abnormal_surfactant_physiolog0.96483058
54MP0000627_abnormal_mammary_gland0.95951871
55MP0002249_abnormal_larynx_morphology0.95872347
56MP0005248_abnormal_Harderian_gland0.95827892
57MP0009931_abnormal_skin_appearance0.95708182
58MP0005666_abnormal_adipose_tissue0.94510072
59MP0000490_abnormal_crypts_of0.94379229
60MP0001958_emphysema0.94321096
61MP0000467_abnormal_esophagus_morphology0.90716158
62MP0000767_abnormal_smooth_muscle0.89107411
63MP0005390_skeleton_phenotype0.88926745
64MP0001243_abnormal_dermal_layer0.88878621
65MP0001730_embryonic_growth_arrest0.87061053
66MP0000579_abnormal_nail_morphology0.86619351
67MP0000733_abnormal_muscle_development0.84562726
68MP0003329_amyloid_beta_deposits0.84247269
69MP0010030_abnormal_orbit_morphology0.83595624
70MP0000343_altered_response_to0.82741784
71MP0005375_adipose_tissue_phenotype0.82723677
72MP0009672_abnormal_birth_weight0.82479545
73MP0010771_integument_phenotype0.81242956
74MP0003075_altered_response_to0.80681805
75MP0005025_abnormal_response_to0.80126993
76MP0004510_myositis0.80025730
77MP0001545_abnormal_hematopoietic_system0.78916519
78MP0005397_hematopoietic_system_phenotyp0.78916519
79MP0003279_aneurysm0.78887339
80MP0000377_abnormal_hair_follicle0.77578226
81MP0009053_abnormal_anal_canal0.76926473
82MP0002080_prenatal_lethality0.76862987
83MP0000537_abnormal_urethra_morphology0.75910337
84MP0005384_cellular_phenotype0.75808138
85MP0005164_abnormal_response_to0.75363807
86MP0003828_pulmonary_edema0.74649847
87MP0001542_abnormal_bone_strength0.73977620
88MP0001881_abnormal_mammary_gland0.73273719
89MP0009780_abnormal_chondrocyte_physiolo0.73245184
90MP0002970_abnormal_white_adipose0.73187230
91MP0008874_decreased_physiological_sensi0.72504088
92MP0002086_abnormal_extraembryonic_tissu0.72252515
93MP0000003_abnormal_adipose_tissue0.71751182
94MP0003448_altered_tumor_morphology0.71653635
95MP0002396_abnormal_hematopoietic_system0.71242653
96MP0002896_abnormal_bone_mineralization0.70502705
97MP0003115_abnormal_respiratory_system0.69373764
98MP0000358_abnormal_cell_content/0.69103767
99MP0010352_gastrointestinal_tract_polyps0.68421650
100MP0005623_abnormal_meninges_morphology0.68151159

Predicted human phenotypes

RankGene SetZ-score
1Micronodular cirrhosis (HP:0001413)3.72916122
2J-shaped sella turcica (HP:0002680)3.67851885
3Hyperacusis (HP:0010780)3.55445978
4Distal lower limb muscle weakness (HP:0009053)3.43740654
5Broad face (HP:0000283)3.35857230
6Vertebral compression fractures (HP:0002953)3.34672645
7Premature rupture of membranes (HP:0001788)3.23696603
8Asymmetry of the thorax (HP:0001555)3.05934044
9Protrusio acetabuli (HP:0003179)2.99979370
10Achilles tendon contracture (HP:0001771)2.90117897
11Cervical subluxation (HP:0003308)2.81637663
12Distal lower limb amyotrophy (HP:0008944)2.80774805
13Increased cerebral lipofuscin (HP:0011813)2.66673623
14Increased connective tissue (HP:0009025)2.66065870
15Thin bony cortex (HP:0002753)2.63084669
16Abnormality of the Achilles tendon (HP:0005109)2.62124535
17Short nail (HP:0001799)2.54454043
18Upper limb amyotrophy (HP:0009129)2.53604462
19Distal upper limb amyotrophy (HP:0007149)2.53604462
20Absent frontal sinuses (HP:0002688)2.51997509
21Cerebral aneurysm (HP:0004944)2.49523199
22Abnormality of glycolipid metabolism (HP:0010969)2.48838266
23Abnormality of liposaccharide metabolism (HP:0010968)2.48838266
24Abnormality of glycosphingolipid metabolism (HP:0004343)2.48838266
25Increased neuronal autofluorescent lipopigment (HP:0002074)2.43604646
26Ulnar bowing (HP:0003031)2.38253684
27Osteolytic defects of the hand bones (HP:0009699)2.29849584
28Osteolytic defects of the phalanges of the hand (HP:0009771)2.29849584
29Dysostosis multiplex (HP:0000943)2.28304672
30Hyperparathyroidism (HP:0000843)2.27638264
31Cholecystitis (HP:0001082)2.27445905
32Abnormal gallbladder physiology (HP:0012438)2.27445905
33Long palpebral fissure (HP:0000637)2.27099829
34Abnormality of macrophages (HP:0004311)2.24735862
35Subacute progressive viral hepatitis (HP:0006572)2.24639226
36Septate vagina (HP:0001153)2.20374954
37Abdominal distention (HP:0003270)2.17676697
38Abnormality of the distal phalanges of the toes (HP:0010182)2.15542279
39Urinary glycosaminoglycan excretion (HP:0003541)2.14079135
40Mucopolysacchariduria (HP:0008155)2.14079135
41Deformed sella turcica (HP:0002681)2.13233260
42Increased serum ferritin (HP:0003281)2.12778610
43Axonal loss (HP:0003447)2.12769746
44Flat acetabular roof (HP:0003180)2.11042178
45Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.08485437
46Esophageal varix (HP:0002040)2.08197067
47Ankle contracture (HP:0006466)2.07730814
48Loss of speech (HP:0002371)2.07072095
49Generalized amyotrophy (HP:0003700)2.06479360
50Disproportionate tall stature (HP:0001519)2.05507323
51Abnormality of the umbilical cord (HP:0010881)2.04582041
52Mitral regurgitation (HP:0001653)2.03952326
53Trismus (HP:0000211)2.03860050
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02804678
55Abnormality of polysaccharide metabolism (HP:0011012)2.02804678
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02804678
57Long toe (HP:0010511)2.01759975
58Nuclear cataract (HP:0100018)2.00616633
59Fragile skin (HP:0001030)1.99915999
60Stridor (HP:0010307)1.95396097
61Rough bone trabeculation (HP:0100670)1.95312924
62Spinal rigidity (HP:0003306)1.93605629
63Insomnia (HP:0100785)1.93399471
64Eczematoid dermatitis (HP:0000976)1.93355897
65Spinal cord compression (HP:0002176)1.93350759
66Arterial tortuosity (HP:0005116)1.92435779
67Elbow flexion contracture (HP:0002987)1.91204791
68Hemorrhage of the eye (HP:0011885)1.91164788
69Patellar dislocation (HP:0002999)1.90989800
70Bone pain (HP:0002653)1.90583181
71Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.89340865
72Back pain (HP:0003418)1.87204335
73Selective tooth agenesis (HP:0001592)1.85620066
74Congenital glaucoma (HP:0001087)1.85540824
75Abnormality of the thoracic spine (HP:0100711)1.85515001
76Easy fatigability (HP:0003388)1.85072611
77Spinal cord lesions (HP:0100561)1.83840576
78Syringomyelia (HP:0003396)1.83840576
79Vascular tortuosity (HP:0004948)1.81892091
80Myocardial infarction (HP:0001658)1.81786304
81Spondylolisthesis (HP:0003302)1.81421374
82Hand muscle atrophy (HP:0009130)1.81046933
83Mildly elevated creatine phosphokinase (HP:0008180)1.78886119
84Microglossia (HP:0000171)1.77288229
85Recurrent abscess formation (HP:0002722)1.76914076
86Hypokinesia (HP:0002375)1.76479511
87Hypercortisolism (HP:0001578)1.74862693
88Cellulitis (HP:0100658)1.74673163
89Blue sclerae (HP:0000592)1.74333047
90Dilatation of the ascending aorta (HP:0005111)1.72987144
91Interstitial pulmonary disease (HP:0006530)1.71737819
92Difficulty climbing stairs (HP:0003551)1.71204855
93Abnormality of the frontal sinuses (HP:0002687)1.68306126
94Renal cell carcinoma (HP:0005584)1.67546792
95Pathologic fracture (HP:0002756)1.65668570
96Sparse lateral eyebrow (HP:0005338)1.64667480
97Aneurysm (HP:0002617)1.63694740
98Advanced eruption of teeth (HP:0006288)1.63340044
99Testicular atrophy (HP:0000029)1.63030406
100Wormian bones (HP:0002645)1.62878719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.11678556
2IRAK34.12498794
3SIK13.96026065
4ERN13.38488499
5MST1R3.07621299
6SMG13.04950353
7NME22.82419736
8EPHA22.72232054
9PKN22.21910033
10ICK1.97593368
11RPS6KB21.97100026
12PRPF4B1.96438361
13TESK11.96082522
14TTN1.94005919
15PAK41.84288399
16SCYL21.76762447
17RIPK11.75846913
18TESK21.65574706
19IRAK41.54780682
20TAOK21.39772348
21MAPKAPK31.36967373
22CDK121.36843730
23MAP2K31.32289717
24IRAK21.30094575
25MET1.25519096
26EPHB11.22061771
27EEF2K1.21727358
28PTK61.20666708
29MAP3K31.18355466
30MAP2K21.17518695
31FGFR41.17460638
32SIK31.15231144
33GRK61.15174397
34PTK21.09940882
35PDGFRA1.08374083
36TAOK11.07828040
37LMTK21.06968668
38PDPK10.97924415
39BMX0.95990292
40TBK10.91627159
41MAP3K110.91164025
42RIPK40.91075912
43LIMK10.90974018
44MTOR0.90333960
45MUSK0.85187994
46PRKCI0.85098159
47PRKD20.84850021
48ILK0.84485796
49RPS6KA20.81823319
50LRRK20.79009575
51ERBB40.77890547
52CDC42BPA0.77800621
53VRK20.76666940
54PRKG20.76125347
55ARAF0.75801560
56CDK70.75496094
57KSR20.74692725
58MAP3K80.72610986
59MAP3K10.71864370
60EIF2AK10.69162555
61MAP4K10.67594155
62CDK80.66068020
63PIM20.62831575
64LATS20.61900378
65MAPKAPK20.61512930
66MAPK110.55822711
67MAP3K100.55378676
68MAP2K10.54691776
69MELK0.53292186
70RPS6KL10.51864440
71RPS6KC10.51864440
72MAP3K90.51261318
73CAMK2G0.49311501
74CHUK0.47918677
75HIPK20.45901597
76CSK0.45569440
77STK380.45473416
78CSF1R0.44986919
79DDR20.43544416
80BRAF0.41745200
81PRKD30.41694190
82IRAK10.41418725
83BRSK10.39101943
84CAMK2B0.38967223
85PDK10.38879662
86RET0.38591219
87ZAP700.38541264
88MAP3K130.38396433
89MARK20.38393566
90TYK20.38048141
91CDK90.37399748
92STK100.37166827
93NEK60.35394133
94AURKA0.32371142
95RPS6KA60.30917658
96CLK10.30880692
97CDK40.30829684
98DAPK10.29939024
99MAP3K140.29600711
100PBK0.29437026

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.31038488
2Other glycan degradation_Homo sapiens_hsa005112.48161425
3Acute myeloid leukemia_Homo sapiens_hsa052212.30391220
4Galactose metabolism_Homo sapiens_hsa000522.24316075
5Fructose and mannose metabolism_Homo sapiens_hsa000512.23601074
6* Pentose phosphate pathway_Homo sapiens_hsa000302.12679689
7Chronic myeloid leukemia_Homo sapiens_hsa052202.04829462
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.98982447
9Bladder cancer_Homo sapiens_hsa052191.98593313
10* Central carbon metabolism in cancer_Homo sapiens_hsa052301.98266245
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.95275441
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.84487529
13Non-small cell lung cancer_Homo sapiens_hsa052231.79298458
14Thyroid cancer_Homo sapiens_hsa052161.72119792
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.61595199
16Lysosome_Homo sapiens_hsa041421.57242335
17VEGF signaling pathway_Homo sapiens_hsa043701.56952922
18Pancreatic cancer_Homo sapiens_hsa052121.54187849
19Endometrial cancer_Homo sapiens_hsa052131.52377112
20Renal cell carcinoma_Homo sapiens_hsa052111.47657320
21mTOR signaling pathway_Homo sapiens_hsa041501.34949806
22Vibrio cholerae infection_Homo sapiens_hsa051101.29629206
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29338764
24Shigellosis_Homo sapiens_hsa051311.28853136
25Osteoclast differentiation_Homo sapiens_hsa043801.27674279
26Hepatitis C_Homo sapiens_hsa051601.26198417
27B cell receptor signaling pathway_Homo sapiens_hsa046621.24460548
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23724847
29Notch signaling pathway_Homo sapiens_hsa043301.22551424
30Proteoglycans in cancer_Homo sapiens_hsa052051.20284659
31ErbB signaling pathway_Homo sapiens_hsa040121.19800926
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17101817
33Insulin signaling pathway_Homo sapiens_hsa049101.13429974
34Glioma_Homo sapiens_hsa052141.12546088
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12433351
36Apoptosis_Homo sapiens_hsa042101.09754308
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08862691
38Hepatitis B_Homo sapiens_hsa051611.08143517
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07909131
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05959738
41Small cell lung cancer_Homo sapiens_hsa052221.04784950
42Focal adhesion_Homo sapiens_hsa045101.03993980
43Prion diseases_Homo sapiens_hsa050201.03759993
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.03076791
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.02789035
46Longevity regulating pathway - mammal_Homo sapiens_hsa042111.02137519
47Biosynthesis of amino acids_Homo sapiens_hsa012301.01516440
48Endocytosis_Homo sapiens_hsa041441.01306863
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01065491
50Sulfur relay system_Homo sapiens_hsa041220.99794569
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98045391
52AMPK signaling pathway_Homo sapiens_hsa041520.94264246
53Amoebiasis_Homo sapiens_hsa051460.93473919
54TNF signaling pathway_Homo sapiens_hsa046680.93080743
55Salmonella infection_Homo sapiens_hsa051320.92403609
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90099623
57Insulin resistance_Homo sapiens_hsa049310.87731795
58HIF-1 signaling pathway_Homo sapiens_hsa040660.85724593
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.85251936
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85110563
61N-Glycan biosynthesis_Homo sapiens_hsa005100.82302675
62Prostate cancer_Homo sapiens_hsa052150.82135445
63Prolactin signaling pathway_Homo sapiens_hsa049170.79761322
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78932317
65Tuberculosis_Homo sapiens_hsa051520.77377484
66Toxoplasmosis_Homo sapiens_hsa051450.76535231
67Estrogen signaling pathway_Homo sapiens_hsa049150.76111403
68Adherens junction_Homo sapiens_hsa045200.75012213
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.74566382
70Choline metabolism in cancer_Homo sapiens_hsa052310.74381869
71MicroRNAs in cancer_Homo sapiens_hsa052060.73243333
72Leishmaniasis_Homo sapiens_hsa051400.72496605
73Melanoma_Homo sapiens_hsa052180.71323450
74Viral carcinogenesis_Homo sapiens_hsa052030.69251565
75Influenza A_Homo sapiens_hsa051640.69077799
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.67844832
77Malaria_Homo sapiens_hsa051440.67746512
78* Carbon metabolism_Homo sapiens_hsa012000.67360272
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67125459
80Inositol phosphate metabolism_Homo sapiens_hsa005620.64301537
81Legionellosis_Homo sapiens_hsa051340.63635893
82HTLV-I infection_Homo sapiens_hsa051660.62800320
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62260907
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.61326659
85Measles_Homo sapiens_hsa051620.60871941
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59441686
87Colorectal cancer_Homo sapiens_hsa052100.59398149
88T cell receptor signaling pathway_Homo sapiens_hsa046600.58906385
89Vitamin B6 metabolism_Homo sapiens_hsa007500.57640976
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56803439
91Epstein-Barr virus infection_Homo sapiens_hsa051690.56112275
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55116979
93Chemokine signaling pathway_Homo sapiens_hsa040620.53566291
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50624786
95GnRH signaling pathway_Homo sapiens_hsa049120.46161202
96Platelet activation_Homo sapiens_hsa046110.45856052
97Phagosome_Homo sapiens_hsa041450.45752132
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43822055
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43472454
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42163791

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