GAB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact5.53932717
2modulation by symbiont of host immune response (GO:0052553)5.53932717
3positive regulation by symbiont of host defense response (GO:0052509)5.53932717
4modulation by symbiont of host defense response (GO:0052031)5.53932717
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.53932717
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.53932717
7positive regulation of gamma-delta T cell activation (GO:0046645)5.02399850
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.99258899
9negative regulation of erythrocyte differentiation (GO:0045647)4.47856738
10macrophage activation involved in immune response (GO:0002281)4.29860139
11regulation of interferon-beta biosynthetic process (GO:0045357)4.11741874
12detection of other organism (GO:0098543)4.07186755
13negative regulation of interleukin-12 production (GO:0032695)3.92309137
14response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.85050077
15response to host immune response (GO:0052572)3.85050077
16microglial cell activation (GO:0001774)3.83558450
17regulation of gamma-delta T cell activation (GO:0046643)3.75727150
18detection of external biotic stimulus (GO:0098581)3.73373949
19detection of bacterium (GO:0016045)3.63741313
20neutrophil activation involved in immune response (GO:0002283)3.60631013
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.59567908
22antigen processing and presentation of endogenous antigen (GO:0019883)3.56524718
23response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.56053140
24response to host (GO:0075136)3.56053140
25response to host defenses (GO:0052200)3.56053140
26negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.54922909
27positive regulation of interferon-alpha production (GO:0032727)3.49472436
28germinal center formation (GO:0002467)3.42139126
29detection of biotic stimulus (GO:0009595)3.37010767
30response to peptidoglycan (GO:0032494)3.32476837
31regulation of T-helper 2 cell differentiation (GO:0045628)3.31480608
32regulation of interferon-alpha production (GO:0032647)3.28999894
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28864291
34regulation of gamma-delta T cell differentiation (GO:0045586)3.17090543
35negative regulation of granulocyte differentiation (GO:0030853)3.16851295
36immunoglobulin mediated immune response (GO:0016064)3.16222539
37macrophage activation (GO:0042116)3.12850407
38positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.11039071
39respiratory burst (GO:0045730)3.10539848
40* regulation of myeloid leukocyte mediated immunity (GO:0002886)3.06033370
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.05232784
42negative regulation of lymphocyte mediated immunity (GO:0002707)3.02407104
43positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.00549996
44positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.94648334
45leukocyte aggregation (GO:0070486)2.91978300
46cellular extravasation (GO:0045123)2.91896927
47positive regulation of macrophage cytokine production (GO:0060907)2.89834672
48myeloid cell activation involved in immune response (GO:0002275)2.86377187
49apoptotic cell clearance (GO:0043277)2.83258633
50B cell receptor signaling pathway (GO:0050853)2.81652908
51negative regulation of leukocyte mediated immunity (GO:0002704)2.81221940
52response to muramyl dipeptide (GO:0032495)2.79312909
53cell adhesion mediated by integrin (GO:0033627)2.78028180
54granulocyte activation (GO:0036230)2.77408696
55* regulation of regulated secretory pathway (GO:1903305)2.77197555
56leukocyte migration involved in inflammatory response (GO:0002523)2.76706474
57detection of molecule of bacterial origin (GO:0032490)2.75071617
58lipopolysaccharide-mediated signaling pathway (GO:0031663)2.74883302
59I-kappaB phosphorylation (GO:0007252)2.74577520
60negative regulation of T cell mediated immunity (GO:0002710)2.73694120
61regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.73290724
62negative regulation of toll-like receptor signaling pathway (GO:0034122)2.73029314
63positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.72310782
64regulation of macrophage cytokine production (GO:0010935)2.71700433
65neutrophil mediated immunity (GO:0002446)2.69709122
66mannose metabolic process (GO:0006013)2.67151248
67positive regulation of cellular amide metabolic process (GO:0034250)2.66605349
68myeloid leukocyte mediated immunity (GO:0002444)2.66347720
69positive regulation of antigen processing and presentation (GO:0002579)2.66218585
70negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.65748980
71cellular response to interferon-alpha (GO:0035457)2.64903644
72defense response to protozoan (GO:0042832)2.64899287
73negative regulation of type 2 immune response (GO:0002829)2.63395047
74positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.63007177
75neutrophil activation (GO:0042119)2.62613606
76regulation of mononuclear cell migration (GO:0071675)2.58926703
77regulation of cholesterol storage (GO:0010885)2.57258187
78glomerular visceral epithelial cell development (GO:0072015)2.56324712
79positive regulation of p38MAPK cascade (GO:1900745)2.55426699
80positive regulation of Rap GTPase activity (GO:0032854)2.53797036
81positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.53680814
82leukocyte degranulation (GO:0043299)2.53117076
83positive regulation of type 2 immune response (GO:0002830)2.52251063
84response to interleukin-15 (GO:0070672)2.52193038
85regulation of tolerance induction (GO:0002643)2.50550750
86positive regulation of heat generation (GO:0031652)2.49407421
87regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.48334099
88response to protozoan (GO:0001562)2.48251749
89regulation of type 2 immune response (GO:0002828)2.48108361
90* regulation of mast cell degranulation (GO:0043304)2.46562925
91regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.45616000
92positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.44470117
93regulation of ARF protein signal transduction (GO:0032012)2.43655702
94regulation of toll-like receptor signaling pathway (GO:0034121)2.42956985
95negative regulation of interleukin-6 production (GO:0032715)2.42952134
96negative regulation of cytokine production involved in immune response (GO:0002719)2.42631900
97regulation of interleukin-12 biosynthetic process (GO:0045075)2.41032912
98positive regulation of natural killer cell differentiation (GO:0032825)2.41030773
99T-helper 1 type immune response (GO:0042088)2.40957329
100production of molecular mediator involved in inflammatory response (GO:0002532)2.39584549
101response to interferon-alpha (GO:0035455)2.39063081
102negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.38563987
103negative regulation of cell killing (GO:0031342)2.38563987
104regulation of dendritic cell antigen processing and presentation (GO:0002604)2.38265698
105positive regulation of chemokine biosynthetic process (GO:0045080)2.38139803
106regulation of T cell tolerance induction (GO:0002664)2.37352804
107neutrophil chemotaxis (GO:0030593)2.37060596
108* positive regulation of mast cell activation (GO:0033005)2.36683127
109* regulation of mast cell activation involved in immune response (GO:0033006)2.36236215
110antigen processing and presentation via MHC class Ib (GO:0002475)2.36122918
111negative regulation of T-helper cell differentiation (GO:0045623)2.35337840
112* regulation of leukocyte degranulation (GO:0043300)2.34022994
113cellular response to type I interferon (GO:0071357)2.33686224
114type I interferon signaling pathway (GO:0060337)2.33686224
115response to type I interferon (GO:0034340)2.33365842
116regulation of B cell receptor signaling pathway (GO:0050855)2.31951287
117* positive regulation of mast cell activation involved in immune response (GO:0033008)2.31927495
118* positive regulation of mast cell degranulation (GO:0043306)2.31927495
119positive regulation of B cell differentiation (GO:0045579)2.31430239
120neutrophil migration (GO:1990266)2.30918537
121positive regulation of interferon-beta production (GO:0032728)2.30711729
122glomerular epithelial cell development (GO:0072310)2.30700248
123regulation of integrin activation (GO:0033623)2.30557776
124regulation of interferon-gamma biosynthetic process (GO:0045072)2.29406791
125wound healing, spreading of epidermal cells (GO:0035313)2.28452398
126interferon-gamma-mediated signaling pathway (GO:0060333)2.27957327
127regulation of chemokine-mediated signaling pathway (GO:0070099)2.27659594
128fibroblast migration (GO:0010761)2.26928626
129regulation of NFAT protein import into nucleus (GO:0051532)2.25099678
130germ cell migration (GO:0008354)2.23927523
131myeloid leukocyte activation (GO:0002274)2.23889122
132* regulation of mast cell activation (GO:0033003)2.23685522
133positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.22735855
134histamine secretion (GO:0001821)2.22539355
135negative regulation of interleukin-17 production (GO:0032700)2.21940132
136monocyte chemotaxis (GO:0002548)2.19760654
137clathrin coat assembly (GO:0048268)2.16416281
138regulation of macrophage chemotaxis (GO:0010758)2.15570188
139regulation of p38MAPK cascade (GO:1900744)2.15278392
140cytokine secretion (GO:0050663)2.14815010
141glomerular basement membrane development (GO:0032836)2.14415874
142pinocytosis (GO:0006907)2.13758681
143JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.13623325
144phagocytosis, engulfment (GO:0006911)2.12147050
145granulocyte chemotaxis (GO:0071621)2.12041559
146negative regulation of mast cell activation (GO:0033004)2.11686063
147negative regulation of macrophage differentiation (GO:0045650)2.11111598
148Arp2/3 complex-mediated actin nucleation (GO:0034314)2.10821926

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.66204503
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.03144690
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.48283024
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.17398366
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.13424067
6* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.02519083
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88901047
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80718055
9* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69470902
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.66886849
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.41606070
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37100745
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.35488344
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.27802179
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07828306
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.06804945
17SCL_19346495_ChIP-Seq_HPC-7_Human2.01505334
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.99020640
19SPI1_23127762_ChIP-Seq_K562_Human1.97244744
20EZH2_22144423_ChIP-Seq_EOC_Human1.96250094
21VDR_24787735_ChIP-Seq_THP-1_Human1.91677546
22* GATA2_21666600_ChIP-Seq_HMVEC_Human1.88872923
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87582759
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70885914
25PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69361404
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66372025
27MYC_22102868_ChIP-Seq_BL_Human1.66334193
28KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64185396
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.63885784
30TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.59058792
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54794521
32* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52546429
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51659646
34PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51262047
35* VDR_24763502_ChIP-Seq_THP-1_Human1.50447010
36NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.48564246
37* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46664270
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45547042
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45030978
40UTX_26944678_Chip-Seq_JUKART_Human1.43359179
41LXR_22292898_ChIP-Seq_THP-1_Human1.43230738
42RUNX_20019798_ChIP-Seq_JUKART_Human1.42152380
43TCF7_22412390_ChIP-Seq_EML_Mouse1.37843680
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33572073
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30064358
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.29832309
47* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27128260
48KDM2B_26808549_Chip-Seq_DND41_Human1.25095810
49VDR_21846776_ChIP-Seq_THP-1_Human1.23149314
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20675032
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20672640
52PU_27001747_Chip-Seq_BMDM_Mouse1.19758066
53KDM2B_26808549_Chip-Seq_K562_Human1.17445987
54MYB_26560356_Chip-Seq_TH1_Human1.17336164
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16825253
56CJUN_26792858_Chip-Seq_BT549_Human1.14128255
57IGF1R_20145208_ChIP-Seq_DFB_Human1.12740383
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12290504
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.12194378
60MAF_26560356_Chip-Seq_TH2_Human1.12121159
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10382907
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10186869
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10116016
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.09733828
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08931648
66DROSHA_22980978_ChIP-Seq_HELA_Human1.07579768
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06982187
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04199167
69SPI1_23547873_ChIP-Seq_NB4_Human1.03657861
70GATA2_19941826_ChIP-Seq_K562_Human1.03637618
71* GATA1_19941827_ChIP-Seq_MEL_Mouse1.03515120
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03398421
73GATA1_19941826_ChIP-Seq_K562_Human1.03215581
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03051085
75MAF_26560356_Chip-Seq_TH1_Human1.03018076
76CLOCK_20551151_ChIP-Seq_293T_Human1.01984766
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.01285096
78* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01097255
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00965629
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00863236
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99614375
82GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99470043
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98865051
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97730652
85* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97596931
86GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97146435
87MYB_26560356_Chip-Seq_TH2_Human0.95795774
88AHR_22903824_ChIP-Seq_MCF-7_Human0.95438108
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95402435
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94675913
91PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94207723
92NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93461168
93* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93320210
94NCOR1_26117541_ChIP-Seq_K562_Human0.93253083
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92249036
96* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92191571
97KDM2B_26808549_Chip-Seq_JURKAT_Human0.92141523
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92075895
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92015248
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91127993
101TBX20_22328084_ChIP-Seq_HEART_Mouse0.91126844
102TBX20_22080862_ChIP-Seq_HEART_Mouse0.91126844
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91053996
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91053996
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90536476
106ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89237990
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89178269
108CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89122210
109* ESR2_21235772_ChIP-Seq_MCF-7_Human0.88872733
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88708310
111DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88673080
112E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86947220
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86786803
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86669432
115GATA1_22025678_ChIP-Seq_K562_Human0.84974478
116FOXO3_23340844_ChIP-Seq_DLD1_Human0.84771014
117* ESR1_21235772_ChIP-Seq_MCF-7_Human0.84470138
118GATA3_27048872_Chip-Seq_THYMUS_Human0.84178540
119* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84129712
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84121849
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83586158
122RACK7_27058665_Chip-Seq_MCF-7_Human0.83174007
123VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82984765
124JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82660707
125* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.82113179
126ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80312632
127MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.80136273
128* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80083752

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.44255577
2MP0003303_peritoneal_inflammation3.47550776
3MP0008438_abnormal_cutaneous_collagen2.88272569
4MP0009278_abnormal_bone_marrow2.73104618
5MP0004510_myositis2.69097937
6MP0001835_abnormal_antigen_presentation2.66036234
7MP0005058_abnormal_lysosome_morphology2.64144598
8MP0003436_decreased_susceptibility_to2.58066799
9MP0002419_abnormal_innate_immunity2.39334055
10MP0003183_abnormal_peptide_metabolism2.33508594
11MP0003172_abnormal_lysosome_physiology2.30364620
12MP0005451_abnormal_body_composition2.20343906
13MP0003724_increased_susceptibility_to2.16594081
14* MP0002148_abnormal_hypersensitivity_rea2.13360154
15MP0003300_gastrointestinal_ulcer2.07764062
16MP0005167_abnormal_blood-brain_barrier2.03875850
17MP0006082_CNS_inflammation2.03639994
18MP0001958_emphysema1.99901134
19MP0005000_abnormal_immune_tolerance1.97124277
20MP0003828_pulmonary_edema1.94085080
21MP0001533_abnormal_skeleton_physiology1.89532307
22MP0009785_altered_susceptibility_to1.89477340
23MP0000343_altered_response_to1.85447496
24MP0008260_abnormal_autophagy1.84239011
25MP0005464_abnormal_platelet_physiology1.83286348
26* MP0005025_abnormal_response_to1.76510700
27MP0008004_abnormal_stomach_pH1.74360617
28MP0002452_abnormal_antigen_presenting1.68619443
29MP0003448_altered_tumor_morphology1.60560786
30MP0001879_abnormal_lymphatic_vessel1.58779224
31MP0003566_abnormal_cell_adhesion1.51596092
32MP0005397_hematopoietic_system_phenotyp1.51324430
33MP0001545_abnormal_hematopoietic_system1.51324430
34MP0003329_amyloid_beta_deposits1.49616764
35MP0002723_abnormal_immune_serum1.47800788
36MP0005387_immune_system_phenotype1.47779348
37MP0001790_abnormal_immune_system1.47779348
38* MP0002998_abnormal_bone_remodeling1.45577901
39MP0004130_abnormal_muscle_cell1.45244240
40MP0002166_altered_tumor_susceptibility1.44906146
41MP0003191_abnormal_cellular_cholesterol1.44332563
42MP0005671_abnormal_response_to1.42463177
43MP0004858_abnormal_nervous_system1.39839367
44MP0002006_tumorigenesis1.39814652
45MP0003091_abnormal_cell_migration1.38609047
46* MP0001819_abnormal_immune_cell1.38387822
47MP0004084_abnormal_cardiac_muscle1.35434263
48MP0008961_abnormal_basal_metabolism1.34767804
49* MP0002420_abnormal_adaptive_immunity1.34219487
50MP0003075_altered_response_to1.31319956
51MP0001800_abnormal_humoral_immune1.29409856
52MP0005409_darkened_coat_color1.29026165
53MP0005275_abnormal_skin_tensile1.28970753
54MP0003045_fibrosis1.27009526
55MP0005076_abnormal_cell_differentiation1.26869857
56MP0000767_abnormal_smooth_muscle1.26011410
57MP0005174_abnormal_tail_pigmentation1.22295528
58MP0003690_abnormal_glial_cell1.20276612
59MP0008775_abnormal_heart_ventricle1.19250306
60MP0005257_abnormal_intraocular_pressure1.19243226
61MP0003279_aneurysm1.18682316
62MP0000685_abnormal_immune_system1.16754815
63MP0001845_abnormal_inflammatory_respons1.16192006
64MP0004808_abnormal_hematopoietic_stem1.15327265
65MP0000920_abnormal_myelination1.13988980
66MP0004381_abnormal_hair_follicle1.13378821
67MP0010386_abnormal_urinary_bladder1.13104936
68MP0000751_myopathy1.12951968
69MP0004947_skin_inflammation1.11639300
70MP0002722_abnormal_immune_system1.11434842
71MP0009764_decreased_sensitivity_to1.11172889
72MP0005164_abnormal_response_to1.11120339
73MP0002132_abnormal_respiratory_system1.11037651
74MP0010368_abnormal_lymphatic_system1.09701329
75MP0005166_decreased_susceptibility_to1.09044551
76* MP0002429_abnormal_blood_cell1.07510559
77MP0000689_abnormal_spleen_morphology1.06770017
78MP0003763_abnormal_thymus_physiology1.06542028
79MP0005310_abnormal_salivary_gland1.06483818
80MP0009115_abnormal_fat_cell1.06020528
81MP0002405_respiratory_system_inflammati1.05967837
82MP0000604_amyloidosis1.05133727
83MP0009840_abnormal_foam_cell1.03444976
84MP0005390_skeleton_phenotype1.02156969
85MP0003705_abnormal_hypodermis_morpholog1.01970242
86MP0004883_abnormal_blood_vessel1.01460544
87MP0000249_abnormal_blood_vessel0.98901138
88MP0003646_muscle_fatigue0.97041934
89MP0005666_abnormal_adipose_tissue0.95996544
90MP0000703_abnormal_thymus_morphology0.95513824
91MP0005503_abnormal_tendon_morphology0.95416653
92MP0003866_abnormal_defecation0.95326154
93MP0004272_abnormal_basement_membrane0.94760649
94MP0008469_abnormal_protein_level0.91470981
95MP0001851_eye_inflammation0.90290033
96MP0005197_abnormal_uvea_morphology0.90214551
97MP0005623_abnormal_meninges_morphology0.86967572
98MP0002972_abnormal_cardiac_muscle0.86716947
99* MP0000716_abnormal_immune_system0.86590805
100MP0002837_dystrophic_cardiac_calcinosis0.86424157
101MP0000733_abnormal_muscle_development0.86292545
102MP0003879_abnormal_hair_cell0.85041475
103* MP0002398_abnormal_bone_marrow0.81970061
104MP0002933_joint_inflammation0.81887585
105MP0004859_abnormal_synaptic_plasticity0.81887374
106MP0002396_abnormal_hematopoietic_system0.81533327
107MP0009333_abnormal_splenocyte_physiolog0.80086880
108MP0008874_decreased_physiological_sensi0.79704163
109MP0000465_gastrointestinal_hemorrhage0.79624107
110MP0000015_abnormal_ear_pigmentation0.79392548
111MP0003656_abnormal_erythrocyte_physiolo0.78740082
112MP0002090_abnormal_vision0.77533206
113MP0010307_abnormal_tumor_latency0.76413390
114MP0000371_diluted_coat_color0.76169741
115MP0003453_abnormal_keratinocyte_physiol0.74914212
116MP0005535_abnormal_body_temperature0.74134534
117MP0002332_abnormal_exercise_endurance0.73392432
118MP0004484_altered_response_of0.73373807
119MP0010630_abnormal_cardiac_muscle0.73337567
120MP0001544_abnormal_cardiovascular_syste0.73026549
121MP0005385_cardiovascular_system_phenoty0.73026549
122MP0000858_altered_metastatic_potential0.72885751
123MP0001853_heart_inflammation0.71798135
124MP0010155_abnormal_intestine_physiology0.71522456
125MP0002295_abnormal_pulmonary_circulatio0.69404281
126MP0002009_preneoplasia0.68693955
127MP0009765_abnormal_xenobiotic_induced0.66649776
128MP0001501_abnormal_sleep_pattern0.66429985
129MP0003632_abnormal_nervous_system0.61058109
130MP0005334_abnormal_fat_pad0.60823734
131MP0002877_abnormal_melanocyte_morpholog0.60769883
132MP0001915_intracranial_hemorrhage0.60629280

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.10757217
2Recurrent bacterial skin infections (HP:0005406)4.77988771
3Increased cerebral lipofuscin (HP:0011813)4.51876344
4Eczematoid dermatitis (HP:0000976)4.47802588
5Recurrent gram-negative bacterial infections (HP:0005420)3.79179479
6Increased neuronal autofluorescent lipopigment (HP:0002074)3.78712420
7Abnormality of glycolipid metabolism (HP:0010969)3.78531009
8Abnormality of liposaccharide metabolism (HP:0010968)3.78531009
9Abnormality of glycosphingolipid metabolism (HP:0004343)3.78531009
10Systemic lupus erythematosus (HP:0002725)3.73919589
11Stomatitis (HP:0010280)3.59829593
12Disinhibition (HP:0000734)3.47596203
13Hematochezia (HP:0002573)3.40410295
14Glomerulonephritis (HP:0000099)3.32767023
15Cerebral aneurysm (HP:0004944)3.27963287
16Abnormality of macrophages (HP:0004311)3.17047511
17Keratoconjunctivitis sicca (HP:0001097)3.13856039
18Gingivitis (HP:0000230)3.13523232
19Gastrointestinal infarctions (HP:0005244)3.07042125
20Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.05488911
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.05474754
22Autoimmune thrombocytopenia (HP:0001973)3.04066944
23Amyloidosis (HP:0011034)3.02820365
24Increased IgE level (HP:0003212)3.00307173
25Dysostosis multiplex (HP:0000943)2.93669485
26Mediastinal lymphadenopathy (HP:0100721)2.85148895
27Meningitis (HP:0001287)2.84236299
28Asymmetric septal hypertrophy (HP:0001670)2.81192246
29Keratoconjunctivitis (HP:0001096)2.80772826
30Prolonged bleeding time (HP:0003010)2.63582901
31Episodic fever (HP:0001954)2.62943522
32Arterial tortuosity (HP:0005116)2.61282804
33Interstitial pulmonary disease (HP:0006530)2.56247873
34Nephritis (HP:0000123)2.55829081
35Abnormality of the fingertips (HP:0001211)2.54805905
36Vacuolated lymphocytes (HP:0001922)2.54683447
37Recurrent skin infections (HP:0001581)2.51400005
38Aortic aneurysm (HP:0004942)2.49680072
39Mutism (HP:0002300)2.48573919
40Myositis (HP:0100614)2.48454391
41Periodontitis (HP:0000704)2.46251507
42Obstructive sleep apnea (HP:0002870)2.45485184
43Neurofibrillary tangles (HP:0002185)2.43949700
44Cellulitis (HP:0100658)2.42241962
45Apathy (HP:0000741)2.40423442
46Urinary glycosaminoglycan excretion (HP:0003541)2.39886898
47Mucopolysacchariduria (HP:0008155)2.39886898
48Axonal loss (HP:0003447)2.39052281
49Urticaria (HP:0001025)2.38862124
50Recurrent cutaneous fungal infections (HP:0011370)2.38037858
51Chronic mucocutaneous candidiasis (HP:0002728)2.38037858
52Orchitis (HP:0100796)2.37663829
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.36436828
54Abnormality of polysaccharide metabolism (HP:0011012)2.36436828
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.36436828
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.36078417
57Encephalitis (HP:0002383)2.34154541
58Obstructive lung disease (HP:0006536)2.32919652
59Chronic obstructive pulmonary disease (HP:0006510)2.32919652
60Vascular tortuosity (HP:0004948)2.31927731
61Tetraparesis (HP:0002273)2.31682663
62Supranuclear gaze palsy (HP:0000605)2.31628531
63Peritonitis (HP:0002586)2.30968290
64Diminished motivation (HP:0000745)2.28078481
65Prostate neoplasm (HP:0100787)2.27709469
66Recurrent fungal infections (HP:0002841)2.25203450
67Myocardial infarction (HP:0001658)2.23019861
68Gingival bleeding (HP:0000225)2.22686687
69Pulmonary embolism (HP:0002204)2.22405484
70Spontaneous hematomas (HP:0007420)2.21704265
71Colitis (HP:0002583)2.21298624
72Leukocytosis (HP:0001974)2.19040451
73Slow saccadic eye movements (HP:0000514)2.18340008
74Loss of speech (HP:0002371)2.16028248
75Inflammation of the large intestine (HP:0002037)2.13727117
76Epistaxis (HP:0000421)2.12993450
77Vertigo (HP:0002321)2.11763776
78Striae distensae (HP:0001065)2.10988264
79Osteolytic defects of the phalanges of the hand (HP:0009771)2.10821754
80Osteolytic defects of the hand bones (HP:0009699)2.10821754
81Hypochromic microcytic anemia (HP:0004840)2.09985386
82Peripheral hypomyelination (HP:0007182)2.07075565
83Gastrointestinal inflammation (HP:0004386)2.06942229
84Arterial thrombosis (HP:0004420)2.04518938
85Papilledema (HP:0001085)2.04456636
86Optic neuritis (HP:0100653)2.03883768
87Retrobulbar optic neuritis (HP:0100654)2.03883768
88Facial diplegia (HP:0001349)2.03762302
89Inappropriate behavior (HP:0000719)2.03564829
90Bone pain (HP:0002653)2.03406843
91Difficulty running (HP:0009046)2.01360841
92Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00912463
93Osteomyelitis (HP:0002754)2.00572489
94Aortic dissection (HP:0002647)1.99883669
95Abnormality of the endocardium (HP:0004306)1.98712142
96Aneurysm (HP:0002617)1.96744318
97Deformed sella turcica (HP:0002681)1.95109036
98Lymphangioma (HP:0100764)1.94600220
99Diplopia (HP:0000651)1.93837077
100Abnormality of binocular vision (HP:0011514)1.93837077
101Abnormality of the peritoneum (HP:0002585)1.91644713
102Pulmonary infiltrates (HP:0002113)1.90089801
103Thick nail (HP:0001805)1.89893558
104Cerebral inclusion bodies (HP:0100314)1.89749158
105Thoracic kyphosis (HP:0002942)1.89079993
106Onion bulb formation (HP:0003383)1.88273532
107Acne (HP:0001061)1.88270007
108Persistence of primary teeth (HP:0006335)1.88114676
109Postural instability (HP:0002172)1.87760221
110J-shaped sella turcica (HP:0002680)1.87594825
111Elevated erythrocyte sedimentation rate (HP:0003565)1.87532888
112Chest pain (HP:0100749)1.86247103
113Frequent falls (HP:0002359)1.85656495
114Progressive visual loss (HP:0000529)1.85635510
115Vasculitis (HP:0002633)1.85222533
116Hypochromic anemia (HP:0001931)1.84422626
117Sepsis (HP:0100806)1.84359651
118Vertebral compression fractures (HP:0002953)1.83536328
119Spondylolisthesis (HP:0003302)1.83031808
120Pulmonary artery stenosis (HP:0004415)1.82482225
121Absent frontal sinuses (HP:0002688)1.81458631
122Granulocytopenia (HP:0001913)1.80642952
123Decreased motor nerve conduction velocity (HP:0003431)1.79472617
124Cortical dysplasia (HP:0002539)1.77796160
125Gangrene (HP:0100758)1.77467440
126Enlarged penis (HP:0000040)1.76884416
127Hemiplegia (HP:0002301)1.75034795
128Subacute progressive viral hepatitis (HP:0006572)1.74699897
129Mesangial abnormality (HP:0001966)1.73689823
130Fatigue (HP:0012378)1.73638899
131T lymphocytopenia (HP:0005403)1.73229747
132Petechiae (HP:0000967)1.72498773
133Metaphyseal cupping (HP:0003021)1.71877595
134Basal ganglia calcification (HP:0002135)1.70683955
135Retinal atrophy (HP:0001105)1.70471264
136Increased CSF protein (HP:0002922)1.70069407
137Polygenic inheritance (HP:0010982)1.70062474
138Anorexia (HP:0002039)1.69658541
139Hypergammaglobulinemia (HP:0010702)1.69205787
140Abnormality of the pleura (HP:0002103)1.68298462
141Polycythemia (HP:0001901)1.67807338
142Segmental peripheral demyelination/remyelination (HP:0003481)1.66161291
143Neuronal loss in central nervous system (HP:0002529)1.66007001
144Recurrent viral infections (HP:0004429)1.64354491
145Abnormality of the lumbar spine (HP:0100712)1.64329893
146Coarse hair (HP:0002208)1.63979340
147Macroorchidism (HP:0000053)1.63809540
148Impaired platelet aggregation (HP:0003540)1.63072529
149Abnormal platelet function (HP:0011869)1.63072529
150Exotropia (HP:0000577)1.62868431
151Hemoptysis (HP:0002105)1.62323960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.24162325
2TGFBR23.01969191
3TBK12.71048628
4RIPK42.62383668
5SIK32.46543899
6TAOK32.38567267
7IRAK42.31618255
8TRIB32.28714913
9TYK22.23724695
10SIK22.19858294
11MAP2K32.15648587
12CAMK1G2.11246712
13CAMK1D2.09325881
14ERN12.06772223
15BLK2.03714480
16MAP3K142.00885279
17RIPK11.98471727
18TTN1.87891818
19JAK11.87332571
20KIT1.84610952
21DMPK1.71331229
22MAP3K91.67390723
23EPHB11.66832245
24MARK21.65686847
25PKN21.60805266
26FGFR31.56061369
27TNK21.50105278
28GRK71.47303472
29TAOK11.42786282
30PDGFRA1.35396279
31IKBKE1.33781217
32MAP3K31.29119018
33EPHA31.28271976
34BMPR21.26753397
35FGFR41.24795726
36CDK121.24732391
37GRK61.24522986
38* ZAP701.24476084
39HCK1.24131127
40MARK11.21395549
41EPHB21.20320359
42NEK91.19172715
43MAP3K21.15819343
44MAP3K121.13273002
45NTRK31.13219878
46RET1.12497091
47JAK31.11797624
48MATK1.10783793
49PTK61.10486273
50MAPK121.09765938
51CHUK1.08802456
52CSF1R1.08331815
53IKBKB1.06059001
54CDC42BPA1.05627057
55FES1.02987499
56SYK1.02317388
57MAP4K11.02297503
58RPS6KA21.00274549
59MAP3K110.97575898
60TAOK20.95235779
61CSK0.93360872
62MAP3K70.92832642
63MARK30.90099832
64PDK10.89907810
65LMTK20.89383277
66SCYL20.87441472
67NTRK20.86904359
68DAPK20.86734088
69KSR10.86552031
70PDGFRB0.86551654
71YES10.85834367
72PTK2B0.84824455
73SGK20.84743634
74MAP3K130.84318989
75MAP3K100.83569992
76BMX0.83077850
77ICK0.79835619
78MYLK0.79215883
79MAPK70.77989626
80ERBB30.77333474
81EGFR0.75550455
82IRAK30.75408896
83* JAK20.74475929
84TXK0.74172952
85PAK40.73432587
86PRKD20.72184277
87STK110.70830999
88SGK30.69741554
89IRAK10.66659633
90TYRO30.65664752
91HIPK20.65033151
92MOS0.65033040
93TIE10.62765757
94NTRK10.62365486
95FGR0.60012535
96MAP3K10.59449276
97CAMKK10.59400292
98TESK10.59273063
99SGK4940.58919707
100SGK2230.58919707
101IRAK20.58478032
102FYN0.55785675
103MAP3K50.55703095
104MAP3K60.55154278
105DYRK1B0.55070994
106RAF10.54922879
107PRKCH0.54661004
108SIK10.54634784
109LRRK20.54531105
110CAMK40.53846946
111LYN0.53798628
112CDK60.52558845
113MINK10.52109177
114FGFR20.51398503
115PHKG20.51274673
116PHKG10.51274673
117PIM20.50768752
118STK30.50488260
119CLK10.50447275
120STK380.49725132
121PAK20.48692264
122RPS6KC10.48255345
123RPS6KL10.48255345
124ABL10.47543138
125KSR20.47376790
126BTK0.46701121
127TRPM70.45882282
128LCK0.45873055
129MAP2K40.45578392
130MAPKAPK20.44625817
131PIK3CG0.44419114
132ITK0.43970194
133ABL20.43572438
134PDPK10.42113211
135EEF2K0.41419153
136WNK10.41121309
137RPS6KA60.39007568
138ERBB20.38939078
139GSK3A0.38887155
140PDK20.38503741
141PRKD10.37891068

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.29739182
2* Osteoclast differentiation_Homo sapiens_hsa043802.11133913
3Toll-like receptor signaling pathway_Homo sapiens_hsa046201.99213980
4Lysosome_Homo sapiens_hsa041421.74519577
5Glycosaminoglycan degradation_Homo sapiens_hsa005311.74325747
6Pertussis_Homo sapiens_hsa051331.73524393
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73018455
8Staphylococcus aureus infection_Homo sapiens_hsa051501.72404630
9Tuberculosis_Homo sapiens_hsa051521.65831776
10Toxoplasmosis_Homo sapiens_hsa051451.57787843
11Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.53367400
12Viral myocarditis_Homo sapiens_hsa054161.50733558
13* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50498430
14Phagosome_Homo sapiens_hsa041451.44180828
15Salmonella infection_Homo sapiens_hsa051321.44108051
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42268230
17B cell receptor signaling pathway_Homo sapiens_hsa046621.41163438
18TNF signaling pathway_Homo sapiens_hsa046681.40435114
19* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37817712
20Malaria_Homo sapiens_hsa051441.36899623
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27055458
22Neurotrophin signaling pathway_Homo sapiens_hsa047221.27040444
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26785421
24Chemokine signaling pathway_Homo sapiens_hsa040621.25372434
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.24564803
26Influenza A_Homo sapiens_hsa051641.23127575
27Legionellosis_Homo sapiens_hsa051341.22643939
28Amoebiasis_Homo sapiens_hsa051461.20380241
29* Chronic myeloid leukemia_Homo sapiens_hsa052201.19768517
30T cell receptor signaling pathway_Homo sapiens_hsa046601.19671020
31Other glycan degradation_Homo sapiens_hsa005111.19431546
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19139172
33Rheumatoid arthritis_Homo sapiens_hsa053231.18760227
34Pancreatic cancer_Homo sapiens_hsa052121.15921543
35Measles_Homo sapiens_hsa051621.15540694
36Shigellosis_Homo sapiens_hsa051311.11328333
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10177529
38Platelet activation_Homo sapiens_hsa046111.07950359
39Dorso-ventral axis formation_Homo sapiens_hsa043201.05252319
40Apoptosis_Homo sapiens_hsa042101.04660632
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.02254330
42Type II diabetes mellitus_Homo sapiens_hsa049301.00699338
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00538240
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00312797
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99564060
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99159194
47Asthma_Homo sapiens_hsa053100.97636655
48Focal adhesion_Homo sapiens_hsa045100.96900934
49Glioma_Homo sapiens_hsa052140.96592110
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.96034376
51Long-term potentiation_Homo sapiens_hsa047200.95731107
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94344397
53Hepatitis B_Homo sapiens_hsa051610.94075629
54Inositol phosphate metabolism_Homo sapiens_hsa005620.93555095
55Dilated cardiomyopathy_Homo sapiens_hsa054140.92752057
56Choline metabolism in cancer_Homo sapiens_hsa052310.92489538
57Autoimmune thyroid disease_Homo sapiens_hsa053200.92352634
58Graft-versus-host disease_Homo sapiens_hsa053320.90496927
59VEGF signaling pathway_Homo sapiens_hsa043700.90207082
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89135921
61Acute myeloid leukemia_Homo sapiens_hsa052210.88387564
62Endocytosis_Homo sapiens_hsa041440.88147022
63Hematopoietic cell lineage_Homo sapiens_hsa046400.86730010
64Renal cell carcinoma_Homo sapiens_hsa052110.86643922
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86230560
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85746430
67Prolactin signaling pathway_Homo sapiens_hsa049170.85486649
68Proteoglycans in cancer_Homo sapiens_hsa052050.84438541
69Small cell lung cancer_Homo sapiens_hsa052220.84356068
70Notch signaling pathway_Homo sapiens_hsa043300.83600895
71Allograft rejection_Homo sapiens_hsa053300.81109461
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79213967
73FoxO signaling pathway_Homo sapiens_hsa040680.78779645
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.77073288
75Type I diabetes mellitus_Homo sapiens_hsa049400.76445475
76Non-small cell lung cancer_Homo sapiens_hsa052230.74880952
77African trypanosomiasis_Homo sapiens_hsa051430.74879951
78Insulin resistance_Homo sapiens_hsa049310.74682168
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74089395
80ECM-receptor interaction_Homo sapiens_hsa045120.74048932
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73839516
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73838542
83Estrogen signaling pathway_Homo sapiens_hsa049150.73176318
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72873061
85HIF-1 signaling pathway_Homo sapiens_hsa040660.72576820
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.72359828
87Insulin signaling pathway_Homo sapiens_hsa049100.69216107
88Hepatitis C_Homo sapiens_hsa051600.69018078
89Colorectal cancer_Homo sapiens_hsa052100.68350904
90Herpes simplex infection_Homo sapiens_hsa051680.68221915
91Renin-angiotensin system_Homo sapiens_hsa046140.67704100
92* Sphingolipid signaling pathway_Homo sapiens_hsa040710.67555163
93* Phospholipase D signaling pathway_Homo sapiens_hsa040720.67426838
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67315540
95mTOR signaling pathway_Homo sapiens_hsa041500.67195505
96Adherens junction_Homo sapiens_hsa045200.66078030
97Renin secretion_Homo sapiens_hsa049240.64201235
98Prion diseases_Homo sapiens_hsa050200.63101628
99Antigen processing and presentation_Homo sapiens_hsa046120.62928612
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62898573
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62377832
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61388537
103Endometrial cancer_Homo sapiens_hsa052130.60763580
104MicroRNAs in cancer_Homo sapiens_hsa052060.60471070
105Long-term depression_Homo sapiens_hsa047300.60291480
106Prostate cancer_Homo sapiens_hsa052150.59791797
107Cholinergic synapse_Homo sapiens_hsa047250.59510459
108GnRH signaling pathway_Homo sapiens_hsa049120.58405089
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58170338
110Rap1 signaling pathway_Homo sapiens_hsa040150.57764069
111MAPK signaling pathway_Homo sapiens_hsa040100.57671108
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57423936
113ErbB signaling pathway_Homo sapiens_hsa040120.55210370
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54592176
115Oxytocin signaling pathway_Homo sapiens_hsa049210.53586525
116* Ras signaling pathway_Homo sapiens_hsa040140.52381696
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52105792

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