GAB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ethanol (GO:0071361)6.34228969
2germinal center formation (GO:0002467)5.98047430
3amyloid precursor protein catabolic process (GO:0042987)5.84189331
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.81423555
5cellular response to interleukin-15 (GO:0071350)4.50611972
6regulation of B cell receptor signaling pathway (GO:0050855)4.38163181
7polyketide metabolic process (GO:0030638)4.29027560
8doxorubicin metabolic process (GO:0044598)4.29027560
9daunorubicin metabolic process (GO:0044597)4.29027560
10regulation of gamma-delta T cell differentiation (GO:0045586)4.26635266
11antigen processing and presentation of endogenous antigen (GO:0019883)4.13248659
12amyloid precursor protein metabolic process (GO:0042982)4.10463911
13positive regulation of gamma-delta T cell activation (GO:0046645)4.07279685
14negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.06809401
15positive regulation of B cell differentiation (GO:0045579)4.05110176
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.03614361
17RNA destabilization (GO:0050779)3.99183916
18negative regulation of interleukin-12 production (GO:0032695)3.90826869
19immunoglobulin mediated immune response (GO:0016064)3.86761398
20positive regulation by symbiont of host defense response (GO:0052509)3.84993773
21modulation by symbiont of host defense response (GO:0052031)3.84993773
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.84993773
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.84993773
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.84993773
25modulation by symbiont of host immune response (GO:0052553)3.84993773
26regulation of B cell differentiation (GO:0045577)3.81027508
27positive regulation of granulocyte differentiation (GO:0030854)3.77210238
28positive thymic T cell selection (GO:0045059)3.75020069
29interferon-gamma production (GO:0032609)3.67763110
30detection of bacterium (GO:0016045)3.67588194
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.64768944
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62190504
33neutrophil activation (GO:0042119)3.60401501
34negative regulation of neurotransmitter secretion (GO:0046929)3.58820563
35regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.57206572
36negative thymic T cell selection (GO:0045060)3.54208778
37T cell migration (GO:0072678)3.53419117
38negative regulation of protein tyrosine kinase activity (GO:0061099)3.51564097
39negative regulation of T cell mediated immunity (GO:0002710)3.49642490
40macrophage activation involved in immune response (GO:0002281)3.49217392
41leukocyte aggregation (GO:0070486)3.49184043
42mast cell activation (GO:0045576)3.48739930
43negative regulation of lymphocyte mediated immunity (GO:0002707)3.45886544
44negative regulation of erythrocyte differentiation (GO:0045647)3.43256352
45positive regulation of mast cell activation (GO:0033005)3.39630106
46regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.35732249
47regulation of natural killer cell mediated immunity (GO:0002715)3.35732249
48positive regulation of receptor recycling (GO:0001921)3.34305418
49regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.33845102
50detection of external biotic stimulus (GO:0098581)3.31303901
51myeloid cell activation involved in immune response (GO:0002275)3.31117053
52granulocyte activation (GO:0036230)3.30384589
53microglial cell activation (GO:0001774)3.29618723
54defense response to protozoan (GO:0042832)3.28480490
55negative regulation of exocytosis (GO:0045920)3.27404036
56positive regulation of interferon-alpha production (GO:0032727)3.27027942
57detection of molecule of bacterial origin (GO:0032490)3.23414799
58regulation of mast cell activation (GO:0033003)3.23104952
59regulation of mast cell degranulation (GO:0043304)3.22896351
60response to interleukin-15 (GO:0070672)3.22627467
61activated T cell proliferation (GO:0050798)3.22417288
62mature B cell differentiation (GO:0002335)3.20971480
63regulation of interferon-alpha production (GO:0032647)3.19028380
64positive regulation of interferon-beta production (GO:0032728)3.16654072
65regulation of tolerance induction (GO:0002643)3.15993681
66positive regulation of mast cell degranulation (GO:0043306)3.15471130
67positive regulation of mast cell activation involved in immune response (GO:0033008)3.15471130
68response to interferon-beta (GO:0035456)3.11670907
69B cell mediated immunity (GO:0019724)3.10885891
70leukocyte degranulation (GO:0043299)3.10458942
71regulation of T cell tolerance induction (GO:0002664)3.09975726
72T cell selection (GO:0045058)3.06434528
73negative regulation of leukocyte mediated immunity (GO:0002704)3.05981796
74megakaryocyte development (GO:0035855)3.05936686
75cerebral cortex radially oriented cell migration (GO:0021799)3.05643619
76regulation of mast cell activation involved in immune response (GO:0033006)3.04877481
77regulation of interferon-beta biosynthetic process (GO:0045357)3.01203430
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.98830127
79Peyers patch development (GO:0048541)2.97690872
80mucosal-associated lymphoid tissue development (GO:0048537)2.97690872
81positive regulation of natural killer cell mediated immunity (GO:0002717)2.96237308
82interferon-gamma-mediated signaling pathway (GO:0060333)2.94791949
83positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.93104314
84positive regulation of antigen processing and presentation (GO:0002579)2.93062807
85B cell receptor signaling pathway (GO:0050853)2.92880969
86lymphoid progenitor cell differentiation (GO:0002320)2.91663436
87response to host immune response (GO:0052572)2.91595130
88response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.91595130
89T cell activation involved in immune response (GO:0002286)2.91586261
90detection of biotic stimulus (GO:0009595)2.90719806
91regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90303692
92response to peptidoglycan (GO:0032494)2.89931876
93regulation of activation of Janus kinase activity (GO:0010533)2.89024135
94keratinocyte development (GO:0003334)2.89015215
95positive regulation of humoral immune response (GO:0002922)2.88596055
96presynaptic membrane assembly (GO:0097105)2.88541489
97mature B cell differentiation involved in immune response (GO:0002313)2.87481429
98antigen processing and presentation via MHC class Ib (GO:0002475)2.87301593
99mesenchymal cell differentiation involved in kidney development (GO:0072161)2.86744864
100mesenchymal cell differentiation involved in renal system development (GO:2001012)2.86744864
101long-chain fatty acid biosynthetic process (GO:0042759)2.86629718
102positive regulation of interleukin-1 beta secretion (GO:0050718)2.86326339
103negative regulation of neurotransmitter transport (GO:0051589)2.86236394
104regulation of leukocyte mediated cytotoxicity (GO:0001910)2.86090868
105regulation of regulatory T cell differentiation (GO:0045589)2.85965401
106superoxide anion generation (GO:0042554)2.85551146
107thymic T cell selection (GO:0045061)2.85293169
108regulation of interferon-beta production (GO:0032648)2.82887928
109positive regulation of alpha-beta T cell proliferation (GO:0046641)2.82859441
110Arp2/3 complex-mediated actin nucleation (GO:0034314)2.82642974
111regulation of T cell mediated cytotoxicity (GO:0001914)2.82336401
112negative regulation of DNA-dependent DNA replication (GO:2000104)2.82249760
113neutrophil mediated immunity (GO:0002446)2.82099597
114positive regulation of interleukin-17 production (GO:0032740)2.81375440
115positive regulation of tolerance induction (GO:0002645)2.81347435
116regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.81176431
117macrophage activation (GO:0042116)2.79635362
118response to protozoan (GO:0001562)2.78333043
119positive regulation of T-helper 1 type immune response (GO:0002827)2.78326683
120T-helper cell differentiation (GO:0042093)2.76656007
121CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.76656007
122cAMP biosynthetic process (GO:0006171)2.73455368
123axon ensheathment in central nervous system (GO:0032291)2.72042723
124central nervous system myelination (GO:0022010)2.72042723
125regulation of gamma-delta T cell activation (GO:0046643)2.69910925
126response to muramyl dipeptide (GO:0032495)2.69159278
127type I interferon signaling pathway (GO:0060337)2.67612495
128cellular response to type I interferon (GO:0071357)2.67612495
129cerebral cortex cell migration (GO:0021795)2.67264377
130mitochondrion morphogenesis (GO:0070584)2.65443755
131antigen receptor-mediated signaling pathway (GO:0050851)2.65216324
132response to type I interferon (GO:0034340)2.63639496
133regulation of neuron projection regeneration (GO:0070570)2.62335241
134regulation of axon regeneration (GO:0048679)2.62335241
135histone H3-K4 trimethylation (GO:0080182)2.62172537
136neutrophil activation involved in immune response (GO:0002283)2.61401018
137positive regulation of interleukin-1 secretion (GO:0050716)2.60599350
138positive T cell selection (GO:0043368)2.60174093
139poly(A)+ mRNA export from nucleus (GO:0016973)2.57674664
140mast cell activation involved in immune response (GO:0002279)2.56856427
141mast cell degranulation (GO:0043303)2.56856427
142alpha-beta T cell differentiation involved in immune response (GO:0002293)2.56650526
143alpha-beta T cell activation involved in immune response (GO:0002287)2.56650526
144T cell differentiation involved in immune response (GO:0002292)2.56650526
145respiratory burst (GO:0045730)2.56568590
146membrane protein ectodomain proteolysis (GO:0006509)2.55957050
147G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.55896692
148negative regulation of stem cell proliferation (GO:2000647)2.54368251
149cellular defense response (GO:0006968)2.54346156
150vesicle targeting (GO:0006903)2.53752047
151cellular extravasation (GO:0045123)2.50306835
152regulation of memory T cell differentiation (GO:0043380)2.49130684
153negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.48882767
154negative regulation of cell killing (GO:0031342)2.48882767
155tolerance induction (GO:0002507)2.48772394
156CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.47237428
157T cell receptor signaling pathway (GO:0050852)2.46583175
158positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.45765936
159regulation of alpha-beta T cell proliferation (GO:0046640)2.44906305
160presynaptic membrane organization (GO:0097090)2.44680062
161negative regulation of execution phase of apoptosis (GO:1900118)2.44341267
162aminoglycoside antibiotic metabolic process (GO:0030647)2.44290842
163detection of other organism (GO:0098543)2.41333582
164endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.38460267
165negative regulation of nitric oxide biosynthetic process (GO:0045019)2.37435614
166positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.37392966
167positive regulation of defense response to virus by host (GO:0002230)2.36963827
168regulation of interleukin-1 beta secretion (GO:0050706)2.35917613
169negative T cell selection (GO:0043383)2.35621488
170NIK/NF-kappaB signaling (GO:0038061)2.32225869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.93104288
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.39691885
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.28278853
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.15800772
5SCL_19346495_ChIP-Seq_HPC-7_Human3.09773160
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.07060578
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.73667905
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.68007673
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.64467515
10GBX2_23144817_ChIP-Seq_PC3_Human2.62803366
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.57028814
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.38408414
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35788152
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.35703965
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34174924
16MYB_26560356_Chip-Seq_TH1_Human2.31639009
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.27228555
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.26984392
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.24457313
20* SPI1_23127762_ChIP-Seq_K562_Human2.23538031
21TAF15_26573619_Chip-Seq_HEK293_Human2.20567457
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17217268
23GATA1_22025678_ChIP-Seq_K562_Human2.15233904
24MAF_26560356_Chip-Seq_TH1_Human2.11090068
25RUNX_20019798_ChIP-Seq_JUKART_Human2.09715757
26VDR_24763502_ChIP-Seq_THP-1_Human2.04295993
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.96743223
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96308423
29GATA3_27048872_Chip-Seq_THYMUS_Human1.95204238
30VDR_22108803_ChIP-Seq_LS180_Human1.94399145
31IGF1R_20145208_ChIP-Seq_DFB_Human1.94155322
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93728851
33UTX_26944678_Chip-Seq_JUKART_Human1.93020768
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.92728036
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.84274136
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.82549888
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79425021
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77566171
39GATA3_26560356_Chip-Seq_TH2_Human1.76414184
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.76060012
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74357510
42GATA1_19941826_ChIP-Seq_K562_Human1.73613783
43* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.73522059
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.73476278
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.71836491
46VDR_21846776_ChIP-Seq_THP-1_Human1.71737304
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71349572
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70948165
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67985859
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.67876263
51VDR_24787735_ChIP-Seq_THP-1_Human1.65923437
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64868680
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63234374
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61496528
55EZH2_22144423_ChIP-Seq_EOC_Human1.60156131
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.58936021
57P300_19829295_ChIP-Seq_ESCs_Human1.58023840
58SUZ12_18555785_Chip-Seq_ESCs_Mouse1.56457555
59P53_22387025_ChIP-Seq_ESCs_Mouse1.54630111
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53746314
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53381951
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.52943173
63STAT3_18555785_Chip-Seq_ESCs_Mouse1.51981812
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.51189901
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49931279
66MYC_22102868_ChIP-Seq_BL_Human1.49267411
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48765154
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.47535380
69MAF_26560356_Chip-Seq_TH2_Human1.47247155
70ER_23166858_ChIP-Seq_MCF-7_Human1.46705510
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.45739735
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.45631126
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43658447
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.43159317
75LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42669518
76FUS_26573619_Chip-Seq_HEK293_Human1.42646525
77NMYC_18555785_Chip-Seq_ESCs_Mouse1.42291544
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.41926190
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41539849
80* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41361899
81STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37262866
82GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37214420
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36635694
84RUNX1_27457419_Chip-Seq_LIVER_Mouse1.35355041
85P300_18555785_Chip-Seq_ESCs_Mouse1.35229339
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34937324
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32897423
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32484955
89GATA2_19941826_ChIP-Seq_K562_Human1.31310839
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.31185190
91JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31166937
92PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30617725
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.30035470
94PU1_27457419_Chip-Seq_LIVER_Mouse1.29691543
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29300981
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28737994
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27053360
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26813259
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26813259
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25408021
101SOX2_18555785_Chip-Seq_ESCs_Mouse1.24906210
102RNF2_27304074_Chip-Seq_NSC_Mouse1.23649338
103PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23284497
104ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21588256
105ZFX_18555785_Chip-Seq_ESCs_Mouse1.20461630
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19970632
107CTCF_18555785_Chip-Seq_ESCs_Mouse1.18920520
108KLF4_18555785_Chip-Seq_ESCs_Mouse1.18902681
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18831475
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.18170231
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15009810
112PU_27001747_Chip-Seq_BMDM_Mouse1.14192037
113EWS_26573619_Chip-Seq_HEK293_Human1.13821052
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12773733
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11880491
116ESRRB_18555785_Chip-Seq_ESCs_Mouse1.11818263
117RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11786551
118GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11666246
119GATA2_21666600_ChIP-Seq_HMVEC_Human1.11438329
120CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10918330
121PIAS1_25552417_ChIP-Seq_VCAP_Human1.10895903
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10057174
123SMAD1_18555785_Chip-Seq_ESCs_Mouse1.09820853
124CBX2_27304074_Chip-Seq_ESCs_Mouse1.09407793
125IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08861597
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08598673
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08537118
128SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08278019
129TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08114948
130SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07920438
131SMRT_27268052_Chip-Seq_Bcells_Human1.07698805
132ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04253094
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04019040
134TCF7_22412390_ChIP-Seq_EML_Mouse1.03601000
135PRDM14_20953172_ChIP-Seq_ESCs_Human1.03515874
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02915179
137STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02300964
138TCF4_23295773_ChIP-Seq_U87_Human1.01250964
139VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00369522
140MYB_26560356_Chip-Seq_TH2_Human1.00336482
141CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99460057
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98672914
143PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98521177
144* SPI1_23547873_ChIP-Seq_NB4_Human0.97054795
145NCOR1_26117541_ChIP-Seq_K562_Human0.96709932
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95383126
147* SMAD4_21799915_ChIP-Seq_A2780_Human0.95257189
148CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94406323
149STAT3_23295773_ChIP-Seq_U87_Human0.94272242
150CIITA_25753668_ChIP-Seq_RAJI_Human0.94027224
151BCL6_27268052_Chip-Seq_Bcells_Human0.93059183
152HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92771824
153STAT1_20625510_ChIP-Seq_HELA_Human0.92044043
154* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91921208
155CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91569473
156NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90626254
157EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89877316
158GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87612134
159SPI1_20517297_ChIP-Seq_HL60_Human0.85341128
160KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84390327
161SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82253638
162* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82236669
163GATA3_26560356_Chip-Seq_TH1_Human0.81446730
164GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81128187
165VDR_23849224_ChIP-Seq_CD4+_Human0.79891162
166ELF1_20517297_ChIP-Seq_JURKAT_Human0.79868789
167RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79101179
168BCOR_27268052_Chip-Seq_Bcells_Human0.77587298
169KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77214642
170P300_27268052_Chip-Seq_Bcells_Human0.77013124
171PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76399235
172CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74323257
173* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.73654702

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.28625181
2MP0006054_spinal_hemorrhage3.27224910
3MP0001188_hyperpigmentation3.09023996
4MP0002876_abnormal_thyroid_physiology2.94500560
5MP0006292_abnormal_olfactory_placode2.80971225
6MP0003303_peritoneal_inflammation2.66892002
7MP0001835_abnormal_antigen_presentation2.56295854
8MP0005409_darkened_coat_color2.42353583
9MP0000685_abnormal_immune_system2.41431560
10MP0008877_abnormal_DNA_methylation2.39403773
11MP0002102_abnormal_ear_morphology2.31444879
12MP0005174_abnormal_tail_pigmentation2.27567462
13MP0001800_abnormal_humoral_immune2.17276321
14MP0005000_abnormal_immune_tolerance2.15337210
15MP0003724_increased_susceptibility_to2.14788916
16MP0009785_altered_susceptibility_to2.10977949
17MP0002277_abnormal_respiratory_mucosa2.10494748
18MP0001790_abnormal_immune_system2.09516392
19MP0005387_immune_system_phenotype2.09516392
20MP0003763_abnormal_thymus_physiology2.08924704
21MP0002723_abnormal_immune_serum2.07518563
22MP0002148_abnormal_hypersensitivity_rea2.02931102
23MP0004510_myositis2.00335505
24MP0005025_abnormal_response_to1.96162002
25MP0009278_abnormal_bone_marrow1.95873122
26MP0002452_abnormal_antigen_presenting1.93224278
27MP0003136_yellow_coat_color1.92749942
28MP0000015_abnormal_ear_pigmentation1.92138665
29MP0002420_abnormal_adaptive_immunity1.91587439
30MP0001851_eye_inflammation1.90843938
31MP0001819_abnormal_immune_cell1.88625051
32MP0005310_abnormal_salivary_gland1.84204510
33MP0002396_abnormal_hematopoietic_system1.83716609
34MP0003880_abnormal_central_pattern1.79555432
35MP0002419_abnormal_innate_immunity1.79399626
36MP0003787_abnormal_imprinting1.78454509
37MP0001545_abnormal_hematopoietic_system1.77517297
38MP0005397_hematopoietic_system_phenotyp1.77517297
39MP0000465_gastrointestinal_hemorrhage1.77388834
40MP0001533_abnormal_skeleton_physiology1.77327522
41MP0004381_abnormal_hair_follicle1.64555960
42MP0003656_abnormal_erythrocyte_physiolo1.62404586
43MP0004742_abnormal_vestibular_system1.60089048
44MP0003300_gastrointestinal_ulcer1.58406769
45MP0003828_pulmonary_edema1.54827590
46MP0002398_abnormal_bone_marrow1.52968889
47MP0001873_stomach_inflammation1.49629308
48MP0000716_abnormal_immune_system1.47220503
49MP0006082_CNS_inflammation1.47160469
50MP0000920_abnormal_myelination1.46415340
51MP0005451_abnormal_body_composition1.43380404
52MP0001986_abnormal_taste_sensitivity1.42603198
53MP0005464_abnormal_platelet_physiology1.39079735
54MP0005645_abnormal_hypothalamus_physiol1.38808356
55MP0008057_abnormal_DNA_replication1.36678381
56MP0000858_altered_metastatic_potential1.33981665
57MP0002405_respiratory_system_inflammati1.32528576
58MP0003329_amyloid_beta_deposits1.31689556
59MP0000689_abnormal_spleen_morphology1.28048182
60MP0000681_abnormal_thyroid_gland1.27445655
61MP0002998_abnormal_bone_remodeling1.26322621
62MP0001486_abnormal_startle_reflex1.26072270
63MP0002722_abnormal_immune_system1.23435895
64MP0005075_abnormal_melanosome_morpholog1.22530857
65MP0008995_early_reproductive_senescence1.16396806
66MP0000703_abnormal_thymus_morphology1.16179368
67MP0002095_abnormal_skin_pigmentation1.15499993
68MP0003690_abnormal_glial_cell1.15105221
69MP0009333_abnormal_splenocyte_physiolog1.14948533
70MP0003191_abnormal_cellular_cholesterol1.14925902
71MP0002933_joint_inflammation1.13982322
72MP0001905_abnormal_dopamine_level1.13787688
73MP0005171_absent_coat_pigmentation1.13159865
74MP0000343_altered_response_to1.10326792
75MP0009763_increased_sensitivity_to1.10080842
76MP0010155_abnormal_intestine_physiology1.09168500
77MP0001853_heart_inflammation1.08995567
78MP0003436_decreased_susceptibility_to1.06768088
79MP0000604_amyloidosis1.06453336
80MP0002429_abnormal_blood_cell1.04984972
81MP0002132_abnormal_respiratory_system1.02973888
82MP0008260_abnormal_autophagy1.02706920
83MP0003866_abnormal_defecation1.01657983
84MP0009379_abnormal_foot_pigmentation0.98213188
85MP0003806_abnormal_nucleotide_metabolis0.93905101
86MP0004808_abnormal_hematopoietic_stem0.93000992
87MP0008058_abnormal_DNA_repair0.92761514
88MP0004130_abnormal_muscle_cell0.91111081
89MP0003075_altered_response_to0.90414637
90MP0004947_skin_inflammation0.90126849
91MP0005058_abnormal_lysosome_morphology0.89655387
92MP0001845_abnormal_inflammatory_respons0.88961080
93MP0009765_abnormal_xenobiotic_induced0.86748370
94MP0005166_decreased_susceptibility_to0.85256299
95MP0004883_abnormal_blood_vessel0.85234016
96MP0005164_abnormal_response_to0.84678040
97MP0000613_abnormal_salivary_gland0.82608531
98MP0003937_abnormal_limbs/digits/tail_de0.82565506
99MP0002019_abnormal_tumor_incidence0.79708267
100MP0002089_abnormal_postnatal_growth/wei0.77438412
101MP0002006_tumorigenesis0.77396320
102MP0001663_abnormal_digestive_system0.77035914
103MP0008469_abnormal_protein_level0.75968677
104MP0009745_abnormal_behavioral_response0.75226541
105MP0003786_premature_aging0.74713972
106MP0003448_altered_tumor_morphology0.73060061
107MP0002638_abnormal_pupillary_reflex0.72144134
108MP0001915_intracranial_hemorrhage0.71113939
109MP0000467_abnormal_esophagus_morphology0.70944842
110MP0002272_abnormal_nervous_system0.70568250
111MP0009115_abnormal_fat_cell0.70218538
112MP0001963_abnormal_hearing_physiology0.69621556
113MP0009764_decreased_sensitivity_to0.67978023
114MP0005390_skeleton_phenotype0.67719141
115MP0001501_abnormal_sleep_pattern0.66601717
116MP0000249_abnormal_blood_vessel0.66504770
117MP0004147_increased_porphyrin_level0.65885238
118MP0002332_abnormal_exercise_endurance0.65529980
119MP0002166_altered_tumor_susceptibility0.65437916
120MP0000778_abnormal_nervous_system0.64825536
121MP0002736_abnormal_nociception_after0.64606623
122MP0005167_abnormal_blood-brain_barrier0.63833404
123MP0002928_abnormal_bile_duct0.63493120
124MP0005379_endocrine/exocrine_gland_phen0.63392344
125MP0003172_abnormal_lysosome_physiology0.63180425
126MP0000647_abnormal_sebaceous_gland0.63041582
127MP0003045_fibrosis0.62774104
128MP0001661_extended_life_span0.62690615
129MP0005319_abnormal_enzyme/_coenzyme0.61477303
130MP0005076_abnormal_cell_differentiation0.60357403
131MP0000372_irregular_coat_pigmentation0.60162137
132MP0004142_abnormal_muscle_tone0.60017127
133MP0005083_abnormal_biliary_tract0.59615386
134MP0003646_muscle_fatigue0.57320624
135MP0000609_abnormal_liver_physiology0.57220870
136MP0004484_altered_response_of0.56614702
137MP0001764_abnormal_homeostasis0.55194573
138MP0006036_abnormal_mitochondrial_physio0.52890234
139MP0002693_abnormal_pancreas_physiology0.52745012
140MP0005376_homeostasis/metabolism_phenot0.52672652
141MP0003795_abnormal_bone_structure0.51885055
142MP0003183_abnormal_peptide_metabolism0.51807693
143MP0008873_increased_physiological_sensi0.49847390

Predicted human phenotypes

RankGene SetZ-score
1Metaphyseal dysplasia (HP:0100255)7.75850779
2Prostate neoplasm (HP:0100787)6.01321879
3Short middle phalanx of the 5th finger (HP:0004220)4.71613035
4Recurrent bacterial skin infections (HP:0005406)4.71192542
5Recurrent abscess formation (HP:0002722)4.65597478
6Abnormality of the phalanges of the 2nd finger (HP:0009541)4.57199199
7Absent frontal sinuses (HP:0002688)4.54680374
8Syringomyelia (HP:0003396)4.50776365
9Spinal cord lesions (HP:0100561)4.50776365
10Spondylolisthesis (HP:0003302)4.25886699
11Agnosia (HP:0010524)4.20816790
12Panhypogammaglobulinemia (HP:0003139)3.91807562
13Abnormality of the prostate (HP:0008775)3.89169356
14Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.69030131
15Abnormality of the parietal bone (HP:0002696)3.68694572
16Abnormality of T cells (HP:0002843)3.59050402
17Prolonged bleeding time (HP:0003010)3.58399461
18Gastrointestinal infarctions (HP:0005244)3.53301272
19Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.44110644
20Recurrent skin infections (HP:0001581)3.39918146
21Granulocytopenia (HP:0001913)3.38817420
22Severe combined immunodeficiency (HP:0004430)3.38240136
23Agammaglobulinemia (HP:0004432)3.35712696
24Spontaneous hematomas (HP:0007420)3.33554648
25Increased IgM level (HP:0003496)3.25619467
26Leukocytosis (HP:0001974)3.23876349
27Autoimmune hemolytic anemia (HP:0001890)3.23855422
28Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.17864273
29Arterial thrombosis (HP:0004420)3.15453571
30Abnormality of the frontal sinuses (HP:0002687)3.11458866
31Recurrent gram-negative bacterial infections (HP:0005420)3.10765333
32Eosinophilia (HP:0001880)3.06812176
33Optic neuritis (HP:0100653)3.06050822
34Retrobulbar optic neuritis (HP:0100654)3.06050822
35Type 2 muscle fiber atrophy (HP:0003554)3.04672693
36Epistaxis (HP:0000421)3.01139703
37Abnormality of B cell number (HP:0010975)3.00585035
38Neurofibrillary tangles (HP:0002185)2.99254072
39Abnormality of eosinophils (HP:0001879)2.91598637
40Supernumerary ribs (HP:0005815)2.90721908
41Neonatal respiratory distress (HP:0002643)2.89625486
42Pulmonary embolism (HP:0002204)2.84531180
43Anorexia (HP:0002039)2.83517795
44Autoimmune thrombocytopenia (HP:0001973)2.82983171
45Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.82515975
46Chest pain (HP:0100749)2.82457858
47Pustule (HP:0200039)2.81953561
48Combined immunodeficiency (HP:0005387)2.81268111
49Abnormality of the heme biosynthetic pathway (HP:0010472)2.79814054
50Eczematoid dermatitis (HP:0000976)2.79493068
51Tubulointerstitial nephritis (HP:0001970)2.75655706
52Hypochromic anemia (HP:0001931)2.73655530
53Recurrent cutaneous fungal infections (HP:0011370)2.68286287
54Chronic mucocutaneous candidiasis (HP:0002728)2.68286287
55Urticaria (HP:0001025)2.64722368
56Abnormality of T cell physiology (HP:0011840)2.64717433
57Supernumerary bones of the axial skeleton (HP:0009144)2.63348536
58Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.60861615
59Myositis (HP:0100614)2.60761812
60Gangrene (HP:0100758)2.60179070
61Petechiae (HP:0000967)2.59127772
62Chronic diarrhea (HP:0002028)2.58324675
63Abnormality of the pleura (HP:0002103)2.54890405
64Hypoproteinemia (HP:0003075)2.54538382
65Polyphagia (HP:0002591)2.52494581
66Abnormality of the 2nd finger (HP:0004100)2.52221074
67Inflammation of the large intestine (HP:0002037)2.51577736
68Gingival bleeding (HP:0000225)2.51064505
69Increased IgE level (HP:0003212)2.50680091
70Orchitis (HP:0100796)2.50349566
71Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47746090
72Polyneuropathy (HP:0001271)2.47695784
73Disinhibition (HP:0000734)2.46744894
74Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.46100719
75Patchy hypopigmentation of hair (HP:0011365)2.45689160
76Thyroiditis (HP:0100646)2.42582974
77Elevated erythrocyte sedimentation rate (HP:0003565)2.41876560
78Muscle fiber atrophy (HP:0100295)2.40575693
79Cellulitis (HP:0100658)2.38312056
80Chromsome breakage (HP:0040012)2.37585534
81Microcytic anemia (HP:0001935)2.36620937
82Abnormality of the phalanges of the 5th finger (HP:0004213)2.34634693
83Abnormality of iron homeostasis (HP:0011031)2.33984356
84Gastrointestinal inflammation (HP:0004386)2.33976982
85Prolonged neonatal jaundice (HP:0006579)2.33448419
86B lymphocytopenia (HP:0010976)2.33241720
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.32996791
88Vertigo (HP:0002321)2.30176228
89Joint swelling (HP:0001386)2.28863237
90Recurrent fungal infections (HP:0002841)2.28693348
91Increased serum ferritin (HP:0003281)2.28687505
92Recurrent bronchitis (HP:0002837)2.28605775
93Keratoconjunctivitis sicca (HP:0001097)2.27670013
94Obstructive lung disease (HP:0006536)2.27040868
95Chronic obstructive pulmonary disease (HP:0006510)2.27040868
96Osteomyelitis (HP:0002754)2.26642114
97Keratitis (HP:0000491)2.26200209
98Colitis (HP:0002583)2.25753338
99Abnormality of macrophages (HP:0004311)2.25481367
100Thickened calvaria (HP:0002684)2.24213144
101Amyotrophic lateral sclerosis (HP:0007354)2.22471109
102Hypergammaglobulinemia (HP:0010702)2.21646557
103Abnormality of primary teeth (HP:0006481)2.21219100
104Glomerulopathy (HP:0100820)2.20616372
105Hypochromic microcytic anemia (HP:0004840)2.20011982
106Lower limb hyperreflexia (HP:0002395)2.19182780
107Abnormal ciliary motility (HP:0012262)2.18911940
108Delayed closure of the anterior fontanelle (HP:0001476)2.17711479
109Short tibia (HP:0005736)2.17639326
110White forelock (HP:0002211)2.17469664
111Gingivitis (HP:0000230)2.17462906
112IgM deficiency (HP:0002850)2.16537472
113Hypoplasia of the thymus (HP:0000778)2.16139442
114Hypoplastic iliac wings (HP:0002866)2.15998545
115Abnormality of transition element cation homeostasis (HP:0011030)2.15283124
116Keratoconjunctivitis (HP:0001096)2.09938718
117Skin rash (HP:0000988)2.09908425
118Pancreatic fibrosis (HP:0100732)2.08850122
119Aplasia/Hypoplasia of the tibia (HP:0005772)2.08397213
120Stomatitis (HP:0010280)2.07985948
121Episodic fever (HP:0001954)2.07421105
122Mediastinal lymphadenopathy (HP:0100721)2.06998730
123Thrombophlebitis (HP:0004418)2.06532587
124Abnormality of lateral ventricle (HP:0030047)2.03001960
125Lymphopenia (HP:0001888)2.02269958
126Increased cerebral lipofuscin (HP:0011813)2.01987703
127Abnormality of male internal genitalia (HP:0000022)2.01645966
128Cupped ear (HP:0000378)1.99748866
129Abnormality of liposaccharide metabolism (HP:0010968)1.99704014
130Abnormality of glycosphingolipid metabolism (HP:0004343)1.99704014
131Abnormality of glycolipid metabolism (HP:0010969)1.99704014
132Sepsis (HP:0100806)1.99290186
133Abnormality of the pubic bones (HP:0003172)1.98408127
134Aplasia/Hypoplasia of the thymus (HP:0010515)1.96798831
135Abnormality of the endocardium (HP:0004306)1.95574968
136Abnormality of cells of the lymphoid lineage (HP:0012140)1.95533624
137Increased neuronal autofluorescent lipopigment (HP:0002074)1.93947793
138Anomalous pulmonary venous return (HP:0010772)1.93943471
139Dynein arm defect of respiratory motile cilia (HP:0012255)1.93402979
140Absent/shortened dynein arms (HP:0200106)1.93402979
141Short femoral neck (HP:0100864)1.93299323
142Meningitis (HP:0001287)1.92158924
143Nonprogressive disorder (HP:0003680)1.91294916
144Verrucae (HP:0200043)1.89895304
145Papilloma (HP:0012740)1.89895304
146Abnormal respiratory motile cilium physiology (HP:0012261)1.85857095
147Encephalitis (HP:0002383)1.82692384
148Xerostomia (HP:0000217)1.80535018
149Abnormal respiratory motile cilium morphology (HP:0005938)1.79192894
150Abnormal respiratory epithelium morphology (HP:0012253)1.79192894
151Akinesia (HP:0002304)1.78144017
152T lymphocytopenia (HP:0005403)1.77672161
153Abnormality of the pulmonary veins (HP:0011718)1.77033272
154Recurrent viral infections (HP:0004429)1.76640698
155Pulmonary infiltrates (HP:0002113)1.76060879
156Abnormal delayed hypersensitivity skin test (HP:0002963)1.75004433
157Submucous cleft hard palate (HP:0000176)1.74935391
158Hemoptysis (HP:0002105)1.74846276
159Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.74809017
160Recurrent pneumonia (HP:0006532)1.74329556
161Abnormality of T cell number (HP:0011839)1.72984235
162Vasculitis (HP:0002633)1.72824195
163Hepatosplenomegaly (HP:0001433)1.71962542
164IgG deficiency (HP:0004315)1.71268819
165Amniotic constriction ring (HP:0009775)1.71109415
166Abnormality of placental membranes (HP:0011409)1.71109415
167Abnormality of dental color (HP:0011073)1.70873191
168Parakeratosis (HP:0001036)1.67852546
169Short clavicles (HP:0000894)1.66483850
170Abnormality of incisor morphology (HP:0011063)1.66429096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.30267245
2CASK3.31049518
3MAP4K13.04469803
4TNIK2.70262739
5JAK32.67571653
6BLK2.57403129
7IRAK32.56014432
8RIPK12.50897243
9IRAK42.31519096
10TEC2.12168118
11AKT32.10922356
12MUSK2.00095070
13KIT1.97302652
14MAP3K141.90643470
15FES1.88399443
16CLK11.82154810
17JAK11.73092850
18MAP2K31.69396673
19MAP3K131.65049107
20TAOK31.60944115
21NUAK11.57022168
22IKBKE1.55999719
23IKBKB1.49671673
24MAP2K61.46262105
25SIK31.45791148
26STK391.41023108
27PRKD21.35770351
28TRPM71.35394851
29YES11.33769861
30OXSR11.33622538
31BMPR21.32903352
32JAK21.31757439
33PKN11.27487265
34SIK21.27254485
35MST41.24583283
36ERN11.23551502
37DYRK1A1.22007818
38MKNK21.21279712
39ADRBK21.19521302
40GRK71.15719204
41IRAK11.13776745
42LCK1.13586047
43MARK31.12175516
44NEK61.11915630
45TGFBR21.06711776
46CDK81.06341576
47BRAF1.06246360
48STK101.02321180
49MAPK131.01269940
50TIE11.01174106
51ZAP700.96408475
52SYK0.94988945
53EIF2AK20.92188017
54PRPF4B0.91913945
55PIM10.90101666
56VRK10.90055269
57DMPK0.88510704
58CSK0.86115086
59LYN0.85251039
60ITK0.83244646
61PIK3CA0.82951767
62BTK0.82531350
63TBK10.82022732
64MARK20.79075911
65MAP3K80.76718248
66MAP3K30.76507731
67EPHB10.76167302
68CSNK1A1L0.76129039
69RIPK40.74881312
70SGK20.73511775
71HCK0.71262544
72MAPK150.71042835
73PTK2B0.69583814
74CDK30.69354458
75CDK190.69223494
76PDPK10.69158765
77PDK20.68482499
78RAF10.66792770
79FRK0.65830278
80GRK10.64994988
81HIPK20.64533655
82PIK3CG0.64428140
83KDR0.63910223
84STK160.63393171
85NLK0.62639315
86TNK20.62545528
87RPS6KA60.62069557
88CSNK1G30.60896950
89FGR0.58001815
90STK110.57571812
91BRD40.56928510
92MAP3K10.56065978
93NTRK30.56038327
94CSF1R0.55924152
95RPS6KC10.55885435
96RPS6KL10.55885435
97MAP3K110.55854284
98MAPK120.55787551
99TYK20.53047139
100ZAK0.52629099
101FYN0.52232715
102GRK60.51877956
103MAP3K50.51152932
104CSNK1G10.50953609
105FGFR30.50856283
106MAPK70.50796265
107MATK0.50653023
108PRKCQ0.49728216
109PDK10.49306500
110IRAK20.48309789
111PRKG10.48156094
112MOS0.48058358
113RET0.47753325
114CDK40.47021677
115SGK2230.46135700
116SGK4940.46135700
117MAP2K20.45622834
118MKNK10.45462728
119MAPK40.45387872
120CHUK0.44666200
121BCR0.43574748
122MAPK110.43364286
123EPHA30.42209499
124MAP3K20.41944941
125MAP3K70.40890539
126PRKCD0.40557935
127TLK10.39127839
128ABL10.38747507
129FLT30.38479713
130ERBB40.38294587
131MAPK30.37500423
132ARAF0.37199187
133MAPKAPK20.36915170
134RPS6KA20.36711148
135LRRK20.36222009
136TESK20.35667084
137ACVR1B0.30183956
138PRKAA20.29993636
139TAOK10.29685764
140KSR20.29198019
141IGF1R0.28319840
142CAMKK20.25906570
143CDK60.23858851
144PRKACG0.21505905
145EGFR0.21242227

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.26494587
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.38841316
3Steroid biosynthesis_Homo sapiens_hsa001002.30827242
4Primary immunodeficiency_Homo sapiens_hsa053402.23338340
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.09993900
6Type I diabetes mellitus_Homo sapiens_hsa049402.09146559
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.02373689
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.78591334
9Measles_Homo sapiens_hsa051621.75625387
10Hematopoietic cell lineage_Homo sapiens_hsa046401.73937930
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67702716
12Allograft rejection_Homo sapiens_hsa053301.63671047
13Leishmaniasis_Homo sapiens_hsa051401.57911500
14Autoimmune thyroid disease_Homo sapiens_hsa053201.51832913
15Ovarian steroidogenesis_Homo sapiens_hsa049131.51076774
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49796721
17Acute myeloid leukemia_Homo sapiens_hsa052211.46952294
18Malaria_Homo sapiens_hsa051441.45373637
19Legionellosis_Homo sapiens_hsa051341.45147090
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.44225942
21Homologous recombination_Homo sapiens_hsa034401.43571010
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41811007
23T cell receptor signaling pathway_Homo sapiens_hsa046601.41217304
24Fanconi anemia pathway_Homo sapiens_hsa034601.40583034
25Osteoclast differentiation_Homo sapiens_hsa043801.39813727
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39605405
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34662701
28Hepatitis B_Homo sapiens_hsa051611.29842756
29Rheumatoid arthritis_Homo sapiens_hsa053231.27831231
30Sphingolipid metabolism_Homo sapiens_hsa006001.25666610
31Platelet activation_Homo sapiens_hsa046111.24038906
32Chemokine signaling pathway_Homo sapiens_hsa040621.23907456
33African trypanosomiasis_Homo sapiens_hsa051431.20095727
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18925703
35Morphine addiction_Homo sapiens_hsa050321.18742380
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.15694001
37B cell receptor signaling pathway_Homo sapiens_hsa046621.14592691
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14555966
39RNA polymerase_Homo sapiens_hsa030201.12490538
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12333077
41Mismatch repair_Homo sapiens_hsa034301.12045215
42Fatty acid elongation_Homo sapiens_hsa000621.11073798
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10837264
44Herpes simplex infection_Homo sapiens_hsa051681.06662632
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00555583
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97107396
47Asthma_Homo sapiens_hsa053100.95373355
48Ether lipid metabolism_Homo sapiens_hsa005650.94353152
49Nicotine addiction_Homo sapiens_hsa050330.92039836
50Influenza A_Homo sapiens_hsa051640.90005945
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89114471
52Antigen processing and presentation_Homo sapiens_hsa046120.87488353
53Other glycan degradation_Homo sapiens_hsa005110.87196807
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86882304
55Hepatitis C_Homo sapiens_hsa051600.85370511
56Staphylococcus aureus infection_Homo sapiens_hsa051500.85313010
57RNA degradation_Homo sapiens_hsa030180.84211342
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83856997
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83846086
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83594055
61Serotonergic synapse_Homo sapiens_hsa047260.83039860
62Non-homologous end-joining_Homo sapiens_hsa034500.81665857
63Apoptosis_Homo sapiens_hsa042100.81465381
64Glutamatergic synapse_Homo sapiens_hsa047240.80289164
65Tuberculosis_Homo sapiens_hsa051520.78708691
66Non-small cell lung cancer_Homo sapiens_hsa052230.77637253
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75646615
68Pancreatic cancer_Homo sapiens_hsa052120.71970458
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71809472
70Cholinergic synapse_Homo sapiens_hsa047250.69361291
71Epstein-Barr virus infection_Homo sapiens_hsa051690.67453900
72Salivary secretion_Homo sapiens_hsa049700.67144432
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66760791
74TNF signaling pathway_Homo sapiens_hsa046680.65802907
75Calcium signaling pathway_Homo sapiens_hsa040200.65635719
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.64639449
77Axon guidance_Homo sapiens_hsa043600.62771424
78Lysosome_Homo sapiens_hsa041420.61929730
79Shigellosis_Homo sapiens_hsa051310.59856162
80Phagosome_Homo sapiens_hsa041450.59536367
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.58854142
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58667985
83Chronic myeloid leukemia_Homo sapiens_hsa052200.57725703
84Alzheimers disease_Homo sapiens_hsa050100.57175369
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57022740
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56562226
87Phototransduction_Homo sapiens_hsa047440.56506855
88Basal transcription factors_Homo sapiens_hsa030220.55967869
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.55785089
90Viral carcinogenesis_Homo sapiens_hsa052030.55650403
91Taste transduction_Homo sapiens_hsa047420.54328003
92Oxidative phosphorylation_Homo sapiens_hsa001900.54069006
93Circadian entrainment_Homo sapiens_hsa047130.53400758
94Toxoplasmosis_Homo sapiens_hsa051450.52764798
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51253259
96Notch signaling pathway_Homo sapiens_hsa043300.51203004
97Purine metabolism_Homo sapiens_hsa002300.51189004
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.50706693
99cAMP signaling pathway_Homo sapiens_hsa040240.50350613
100HTLV-I infection_Homo sapiens_hsa051660.50175853
101Salmonella infection_Homo sapiens_hsa051320.50116245
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49686591
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48611326
104Long-term depression_Homo sapiens_hsa047300.47448440
105Arachidonic acid metabolism_Homo sapiens_hsa005900.46007646
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.45127735
107MAPK signaling pathway_Homo sapiens_hsa040100.44892044
108VEGF signaling pathway_Homo sapiens_hsa043700.44518586
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.44449331
110Base excision repair_Homo sapiens_hsa034100.44422088
111Oxytocin signaling pathway_Homo sapiens_hsa049210.44123205
112Viral myocarditis_Homo sapiens_hsa054160.44111781
113Pancreatic secretion_Homo sapiens_hsa049720.43533165
114Gastric acid secretion_Homo sapiens_hsa049710.43009132
115Regulation of autophagy_Homo sapiens_hsa041400.42754968
116Pertussis_Homo sapiens_hsa051330.42533565
117DNA replication_Homo sapiens_hsa030300.41817178
118Dorso-ventral axis formation_Homo sapiens_hsa043200.41346065
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41259309
120GnRH signaling pathway_Homo sapiens_hsa049120.40932898
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40368857
122Olfactory transduction_Homo sapiens_hsa047400.39907745
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39673972
124Choline metabolism in cancer_Homo sapiens_hsa052310.37183509
125Insulin resistance_Homo sapiens_hsa049310.33903828
126Prolactin signaling pathway_Homo sapiens_hsa049170.33858659
127mTOR signaling pathway_Homo sapiens_hsa041500.33029123
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.32865766
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32280211
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32055890
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31832375
132FoxO signaling pathway_Homo sapiens_hsa040680.31488645
133Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30038461
134Systemic lupus erythematosus_Homo sapiens_hsa053220.26221067
135HIF-1 signaling pathway_Homo sapiens_hsa040660.25634331
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25199456
137Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25098427
138Endocytosis_Homo sapiens_hsa041440.24368596
139Colorectal cancer_Homo sapiens_hsa052100.21619711
140Linoleic acid metabolism_Homo sapiens_hsa005910.21618108
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20386772
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.17742667
143Renal cell carcinoma_Homo sapiens_hsa052110.17571588
144Nitrogen metabolism_Homo sapiens_hsa009100.12603415

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