GABARAPL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.63912657
2establishment of protein localization to mitochondrial membrane (GO:0090151)5.47267810
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.27209968
4protein neddylation (GO:0045116)4.79098952
5ATP synthesis coupled proton transport (GO:0015986)4.74493667
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.74493667
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.64015811
8chaperone-mediated protein transport (GO:0072321)4.49659282
9regulation of cellular amino acid metabolic process (GO:0006521)4.46555807
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.43744602
11transcription elongation from RNA polymerase III promoter (GO:0006385)4.37304330
12termination of RNA polymerase III transcription (GO:0006386)4.37304330
13positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.36025163
14regulation of mitochondrial translation (GO:0070129)4.31337095
15L-methionine salvage (GO:0071267)4.20368887
16L-methionine biosynthetic process (GO:0071265)4.20368887
17amino acid salvage (GO:0043102)4.20368887
187-methylguanosine mRNA capping (GO:0006370)4.11384532
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.11078203
20anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.07525348
21negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.06484756
22negative regulation of ligase activity (GO:0051352)4.06484756
23pyrimidine nucleobase catabolic process (GO:0006208)4.05238126
24RNA capping (GO:0036260)3.99922338
257-methylguanosine RNA capping (GO:0009452)3.99922338
26L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.91348786
27respiratory electron transport chain (GO:0022904)3.88225582
28neuron cell-cell adhesion (GO:0007158)3.86554852
29establishment of protein localization to mitochondrion (GO:0072655)3.85005169
30cullin deneddylation (GO:0010388)3.84326787
31positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.82877046
32electron transport chain (GO:0022900)3.80008677
33synaptic vesicle maturation (GO:0016188)3.75490764
34protein targeting to mitochondrion (GO:0006626)3.72543179
35positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.71579375
36synaptic vesicle exocytosis (GO:0016079)3.69764373
37neuronal action potential propagation (GO:0019227)3.67884473
38DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.66678405
39signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.64844179
40signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.64844179
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.64844179
42ribosome assembly (GO:0042255)3.64136848
43signal transduction involved in DNA damage checkpoint (GO:0072422)3.64007482
44signal transduction involved in DNA integrity checkpoint (GO:0072401)3.64007482
45positive regulation of ligase activity (GO:0051351)3.63559931
46protein localization to mitochondrion (GO:0070585)3.62035626
47signal transduction involved in cell cycle checkpoint (GO:0072395)3.59228177
48guanosine-containing compound biosynthetic process (GO:1901070)3.58932144
49regulation of cellular amine metabolic process (GO:0033238)3.58804631
50negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.58771166
51intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.57742562
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.57742562
53purine nucleobase biosynthetic process (GO:0009113)3.54399364
54transcription elongation from RNA polymerase I promoter (GO:0006362)3.53356549
55protein deneddylation (GO:0000338)3.51968345
56rRNA modification (GO:0000154)3.50832560
57negative regulation of heart rate (GO:0010459)3.50367819
58presynaptic membrane assembly (GO:0097105)3.46864022
59positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.45129620
60keratinocyte development (GO:0003334)3.44754475
61postsynaptic membrane organization (GO:0001941)3.44717480
62presynaptic membrane organization (GO:0097090)3.43668103
63nucleobase catabolic process (GO:0046113)3.42119977
64neuron-neuron synaptic transmission (GO:0007270)3.35552083
65ionotropic glutamate receptor signaling pathway (GO:0035235)3.35128863
66GDP-mannose metabolic process (GO:0019673)3.35071346
67gamma-aminobutyric acid transport (GO:0015812)3.34728461
68neurofilament cytoskeleton organization (GO:0060052)3.33954234
69transmission of nerve impulse (GO:0019226)3.31530983
70GTP biosynthetic process (GO:0006183)3.31070624
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30807746
72regulation of ubiquitin-protein transferase activity (GO:0051438)3.28878361
73synaptic transmission, glutamatergic (GO:0035249)3.28531710
74behavioral response to nicotine (GO:0035095)3.28232966
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.28056550
76regulation of synaptic vesicle exocytosis (GO:2000300)3.27796961
77termination of RNA polymerase I transcription (GO:0006363)3.26115612
78central nervous system myelination (GO:0022010)3.25733147
79axon ensheathment in central nervous system (GO:0032291)3.25733147
80long-chain fatty acid biosynthetic process (GO:0042759)3.25592641
81protein localization to cilium (GO:0061512)3.24910218
82transcription from RNA polymerase I promoter (GO:0006360)3.23167364
83blastocyst development (GO:0001824)3.21306598
84protein complex biogenesis (GO:0070271)3.20170493
85glutamate receptor signaling pathway (GO:0007215)3.18821408
86amino sugar catabolic process (GO:0046348)3.16976581
87regulation of synapse structural plasticity (GO:0051823)3.15825745
88regulation of ligase activity (GO:0051340)3.15024144
89short-term memory (GO:0007614)3.13990521
90platelet dense granule organization (GO:0060155)3.13368610
91nucleoside diphosphate phosphorylation (GO:0006165)3.10441187
92mitochondrial respiratory chain complex I assembly (GO:0032981)3.10230916
93NADH dehydrogenase complex assembly (GO:0010257)3.10230916
94mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.10230916
95detection of calcium ion (GO:0005513)3.08776729
96regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08181070
97protein-cofactor linkage (GO:0018065)3.07264035
98folic acid transport (GO:0015884)3.05726097
99regulation of synaptic vesicle transport (GO:1902803)3.05189869
100ATP hydrolysis coupled proton transport (GO:0015991)3.05169480
101energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.05169480
102glutamate secretion (GO:0014047)3.05101115
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04374948
104glycosphingolipid biosynthetic process (GO:0006688)3.03895616
105negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01582735
106sequestering of actin monomers (GO:0042989)3.00935333
107neurotransmitter secretion (GO:0007269)2.99940140
108methionine biosynthetic process (GO:0009086)2.99154649
109G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.98402221
110protein localization to synapse (GO:0035418)2.98192245
111peptidyl-histidine modification (GO:0018202)2.98048164
112neurotransmitter uptake (GO:0001504)2.98026634
113GMP metabolic process (GO:0046037)2.96135091
114antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.95621042
115negative regulation of appetite (GO:0032099)2.92421508
116negative regulation of response to food (GO:0032096)2.92421508
117mitochondrial respiratory chain complex assembly (GO:0033108)2.90418262
118transcription initiation from RNA polymerase I promoter (GO:0006361)2.88397655
119C4-dicarboxylate transport (GO:0015740)2.86205926
120positive regulation of amino acid transport (GO:0051957)2.85693451
121synapse assembly (GO:0007416)2.85612841
122transcription elongation from RNA polymerase II promoter (GO:0006368)2.85361734
123auditory behavior (GO:0031223)2.85346949
124nucleobase biosynthetic process (GO:0046112)2.85339309
125intracellular protein transmembrane import (GO:0044743)2.85305141
126intestinal epithelial cell development (GO:0060576)2.85271483
127transferrin transport (GO:0033572)2.85125794
128nonmotile primary cilium assembly (GO:0035058)2.84363357
129negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.83281999
130UTP biosynthetic process (GO:0006228)2.82174442
131protein transmembrane transport (GO:0071806)2.80419084
132neurotransmitter catabolic process (GO:0042135)2.79652751
133regulation of cilium movement (GO:0003352)2.78935737
134positive regulation of cell cycle arrest (GO:0071158)2.78834649
135autophagic vacuole assembly (GO:0000045)2.78736746
136dopamine transport (GO:0015872)2.77703949
137DNA-templated transcription, elongation (GO:0006354)2.77446071
138negative regulation of protein ubiquitination (GO:0031397)2.76094054
139lung-associated mesenchyme development (GO:0060484)2.74993167
140regulation of synaptic transmission, glutamatergic (GO:0051966)2.73812237
141NADH metabolic process (GO:0006734)2.73461798
142behavioral response to cocaine (GO:0048148)2.72734353
143epithelial cilium movement (GO:0003351)2.72257981
144regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.71921249
145negative regulation of cation channel activity (GO:2001258)2.71662552
146methionine metabolic process (GO:0006555)2.70535761
147positive regulation of viral transcription (GO:0050434)2.69414856
148axonal fasciculation (GO:0007413)2.69091313
149regulation of short-term neuronal synaptic plasticity (GO:0048172)2.68937915
150cellular response to leptin stimulus (GO:0044320)2.67783027
151hydrogen ion transmembrane transport (GO:1902600)2.64985203
152neuromuscular process controlling posture (GO:0050884)2.64385381
153gamma-aminobutyric acid signaling pathway (GO:0007214)2.62530330
154establishment of mitochondrion localization (GO:0051654)2.61999339
155prepulse inhibition (GO:0060134)2.61715788
156DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.61590178
157DNA damage response, detection of DNA damage (GO:0042769)2.61062285
158regulation of neurotransmitter levels (GO:0001505)2.60818694
159establishment of melanosome localization (GO:0032401)2.60512910
160positive regulation of mitochondrial fission (GO:0090141)2.59310965
161melanosome transport (GO:0032402)2.59272134
162ferric iron transport (GO:0015682)2.59243454
163regulation of neurotransmitter uptake (GO:0051580)2.58526875
164positive regulation of synaptic transmission, GABAergic (GO:0032230)2.58379696
165positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.58024068
166positive regulation of potassium ion transmembrane transport (GO:1901381)2.57706310
167cerebellar granule cell differentiation (GO:0021707)2.56168562
168proton transport (GO:0015992)2.55805742
169regulation of neurotransmitter transport (GO:0051588)2.55391070
170regulation of neurotransmitter secretion (GO:0046928)2.54347525
171negative regulation of calcium ion transmembrane transport (GO:1903170)2.54129495
172negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.54129495
173startle response (GO:0001964)2.53453650
174positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.52935324
175hydrogen transport (GO:0006818)2.52455931
176exploration behavior (GO:0035640)2.52380100
177regulation of microtubule-based movement (GO:0060632)2.51560878
178vocalization behavior (GO:0071625)2.50789325
179neuromuscular synaptic transmission (GO:0007274)2.50761464
180neurotransmitter transport (GO:0006836)2.50269503
181adult walking behavior (GO:0007628)2.50167233
182membrane depolarization during action potential (GO:0086010)2.50080478

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.35966474
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.61744999
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.28033407
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.22428479
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.19378730
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.95448172
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.89396867
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.66386475
9GBX2_23144817_ChIP-Seq_PC3_Human3.42371096
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.40948148
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.97299141
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.68596732
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.67249997
14* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.56266524
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.46064822
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.45791984
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45393073
18IGF1R_20145208_ChIP-Seq_DFB_Human2.42951851
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.36341492
20VDR_23849224_ChIP-Seq_CD4+_Human2.33437979
21ZNF274_21170338_ChIP-Seq_K562_Hela2.31988217
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.30628681
23* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20556699
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97544582
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96803510
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95252421
27P300_19829295_ChIP-Seq_ESCs_Human1.93928125
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93339892
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.91515115
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87315523
31DCP1A_22483619_ChIP-Seq_HELA_Human1.84041714
32FUS_26573619_Chip-Seq_HEK293_Human1.83049985
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81021826
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79910935
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79135663
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75314829
37RNF2_27304074_Chip-Seq_NSC_Mouse1.73861111
38SMAD4_21799915_ChIP-Seq_A2780_Human1.68044937
39* GABP_19822575_ChIP-Seq_HepG2_Human1.67556280
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66999463
41* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63240911
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.62370268
43EWS_26573619_Chip-Seq_HEK293_Human1.61504727
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61014072
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59924918
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58507026
47CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.57953867
48* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55387074
49XRN2_22483619_ChIP-Seq_HELA_Human1.55045661
50* ELK1_22589737_ChIP-Seq_MCF10A_Human1.54687353
51VDR_22108803_ChIP-Seq_LS180_Human1.52370617
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52004178
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51811128
54FOXP3_21729870_ChIP-Seq_TREG_Human1.49464806
55AR_25329375_ChIP-Seq_VCAP_Human1.49017657
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48765501
57HTT_18923047_ChIP-ChIP_STHdh_Human1.48112232
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.47593068
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47373735
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47121042
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45796512
62* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40119949
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40004015
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.39727942
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.39579536
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38280229
67* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.38023567
68TTF2_22483619_ChIP-Seq_HELA_Human1.37861086
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37480887
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36856805
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36728186
72* ELK1_19687146_ChIP-ChIP_HELA_Human1.36462193
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34801559
74TP53_22573176_ChIP-Seq_HFKS_Human1.34352056
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.32652905
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31596661
77ZNF263_19887448_ChIP-Seq_K562_Human1.30149697
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29801036
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29548642
80ER_23166858_ChIP-Seq_MCF-7_Human1.29102965
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27611869
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27219984
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27107347
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26633002
85SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25762105
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24176302
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.23742306
88BCAT_22108803_ChIP-Seq_LS180_Human1.23381647
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.23082000
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22244221
91ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22134653
92JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21834721
93SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20646318
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19670197
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19332139
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.17984849
97NANOG_19829295_ChIP-Seq_ESCs_Human1.17126352
98SOX2_19829295_ChIP-Seq_ESCs_Human1.17126352
99POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16822172
100MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16288180
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14491924
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13787543
103NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.13420377
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13277799
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12491654
106NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12359252
107TAF15_26573619_Chip-Seq_HEK293_Human1.12166646
108* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12160336
109STAT3_23295773_ChIP-Seq_U87_Human1.12060988
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11886025
111TCF4_23295773_ChIP-Seq_U87_Human1.10846881
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10844498
113CBP_20019798_ChIP-Seq_JUKART_Human1.10844498
114P53_22387025_ChIP-Seq_ESCs_Mouse1.10316912
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10032190
116JUN_21703547_ChIP-Seq_K562_Human1.09267020
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09255296
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08656532
119PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07770170
120* REST_21632747_ChIP-Seq_MESCs_Mouse1.07650134
121SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07621309
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06906667
123SOX17_20123909_ChIP-Seq_XEN_Mouse1.06793149
124* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06745485
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.06277940
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06238837
127RUNX2_22187159_ChIP-Seq_PCA_Human1.06194541
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05857321
129EZH2_27294783_Chip-Seq_NPCs_Mouse1.04951426
130KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03412802
131PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03306570
132MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02772671
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02200247
134IRF1_19129219_ChIP-ChIP_H3396_Human1.01917626
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01052899
136TCF4_22108803_ChIP-Seq_LS180_Human0.99932089
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99901469
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99901469
139* SOX2_21211035_ChIP-Seq_LN229_Gbm0.99502376
140* REST_18959480_ChIP-ChIP_MESCs_Mouse0.99089540
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98177364
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97574082
143EZH2_22144423_ChIP-Seq_EOC_Human0.96890047
144FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96370990
145KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96308498
146ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95202264
147KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94519208
148KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94519208
149KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94519208
150KDM5A_27292631_Chip-Seq_BREAST_Human0.92287180
151TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.89753525
152BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86961352
153NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85833665
154EOMES_21245162_ChIP-Seq_HESCs_Human0.84849849
155SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82113355
156CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82102396
157SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81911545
158OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81091577
159MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.79415959
160GATA1_26923725_Chip-Seq_HPCs_Mouse0.78853115
161* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78677873
162YY1_22570637_ChIP-Seq_MALME-3M_Human0.77559537
163CTBP2_25329375_ChIP-Seq_LNCAP_Human0.76944020
164REST_19997604_ChIP-ChIP_NEURONS_Mouse0.76934391
165FLI1_27457419_Chip-Seq_LIVER_Mouse0.76710589
166SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76024382
167CTCF_18555785_ChIP-Seq_MESCs_Mouse0.74804999
168NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.73250350
169* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.71545606
170FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.70908708
171CTBP1_25329375_ChIP-Seq_LNCAP_Human0.70675254
172SOX2_16153702_ChIP-ChIP_HESCs_Human0.70604876
173SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.69782508
174ETV2_25802403_ChIP-Seq_MESCs_Mouse0.69595460
175PCGF2_27294783_Chip-Seq_ESCs_Mouse0.69408838
176TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.67921252
177* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.67493088

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008260_abnormal_autophagy3.73821700
2MP0003880_abnormal_central_pattern3.51570733
3MP0001529_abnormal_vocalization3.16623978
4MP0003693_abnormal_embryo_hatching2.76916151
5MP0003718_maternal_effect2.76121036
6MP0001905_abnormal_dopamine_level2.64388014
7MP0004270_analgesia2.55668841
8MP0003787_abnormal_imprinting2.36479472
9MP0001440_abnormal_grooming_behavior2.32496671
10MP0002734_abnormal_mechanical_nocicepti2.30668204
11MP0009046_muscle_twitch2.20615660
12MP0006276_abnormal_autonomic_nervous2.19053526
13MP0002064_seizures2.10407920
14MP0003011_delayed_dark_adaptation2.09135640
15MP0002272_abnormal_nervous_system2.07134298
16MP0003329_amyloid_beta_deposits1.96538500
17MP0004859_abnormal_synaptic_plasticity1.90429122
18MP0001968_abnormal_touch/_nociception1.88174738
19MP0004957_abnormal_blastocyst_morpholog1.85169478
20MP0004142_abnormal_muscle_tone1.85164315
21MP0003635_abnormal_synaptic_transmissio1.85063965
22MP0001970_abnormal_pain_threshold1.80786503
23MP0002735_abnormal_chemical_nociception1.78067428
24MP0009745_abnormal_behavioral_response1.74932524
25MP0006035_abnormal_mitochondrial_morpho1.74181527
26MP0002822_catalepsy1.71083117
27MP0002102_abnormal_ear_morphology1.70769550
28MP0002909_abnormal_adrenal_gland1.66591416
29MP0001986_abnormal_taste_sensitivity1.64325057
30MP0005423_abnormal_somatic_nervous1.63924223
31MP0002733_abnormal_thermal_nociception1.63083372
32MP0002572_abnormal_emotion/affect_behav1.62750447
33MP0003136_yellow_coat_color1.62506952
34MP0001501_abnormal_sleep_pattern1.53614542
35MP0005253_abnormal_eye_physiology1.49841835
36MP0002736_abnormal_nociception_after1.49537032
37MP0003806_abnormal_nucleotide_metabolis1.48721977
38MP0008932_abnormal_embryonic_tissue1.48196935
39MP0004043_abnormal_pH_regulation1.46796288
40MP0001486_abnormal_startle_reflex1.46497294
41MP0002063_abnormal_learning/memory/cond1.45175446
42MP0002067_abnormal_sensory_capabilities1.44376180
43MP0005386_behavior/neurological_phenoty1.44339189
44MP0004924_abnormal_behavior1.44339189
45MP0001542_abnormal_bone_strength1.43179920
46MP0003315_abnormal_perineum_morphology1.43033692
47MP0001661_extended_life_span1.42166723
48MP0005646_abnormal_pituitary_gland1.41046058
49MP0002876_abnormal_thyroid_physiology1.40983265
50MP0004147_increased_porphyrin_level1.40603717
51MP0003195_calcinosis1.40512708
52MP0005499_abnormal_olfactory_system1.39124228
53MP0005394_taste/olfaction_phenotype1.39124228
54MP0001188_hyperpigmentation1.38827032
55MP0000013_abnormal_adipose_tissue1.38823802
56MP0010386_abnormal_urinary_bladder1.38437885
57MP0006072_abnormal_retinal_apoptosis1.36922582
58MP0003111_abnormal_nucleus_morphology1.35391501
59MP0006036_abnormal_mitochondrial_physio1.34914718
60MP0002184_abnormal_innervation1.34589915
61MP0002638_abnormal_pupillary_reflex1.33536960
62MP0002653_abnormal_ependyma_morphology1.33460200
63MP0001727_abnormal_embryo_implantation1.33430003
64MP0004811_abnormal_neuron_physiology1.32127189
65MP0003121_genomic_imprinting1.27297483
66MP0001984_abnormal_olfaction1.26908094
67MP0003633_abnormal_nervous_system1.26083709
68MP0005379_endocrine/exocrine_gland_phen1.25852360
69MP0002163_abnormal_gland_morphology1.25378904
70MP0002229_neurodegeneration1.23993866
71MP0008789_abnormal_olfactory_epithelium1.23590511
72MP0000920_abnormal_myelination1.23330558
73MP0005084_abnormal_gallbladder_morpholo1.19242984
74MP0004215_abnormal_myocardial_fiber1.18385425
75MP0000778_abnormal_nervous_system1.16864013
76MP0008877_abnormal_DNA_methylation1.16579617
77MP0004742_abnormal_vestibular_system1.15484740
78MP0009840_abnormal_foam_cell1.14991372
79MP0001485_abnormal_pinna_reflex1.13014096
80MP0003786_premature_aging1.12013109
81MP0003879_abnormal_hair_cell1.11712570
82MP0002066_abnormal_motor_capabilities/c1.09265509
83MP0003938_abnormal_ear_development1.07690995
84MP0005377_hearing/vestibular/ear_phenot1.07216055
85MP0003878_abnormal_ear_physiology1.07216055
86MP0004885_abnormal_endolymph1.06954073
87MP0008872_abnormal_physiological_respon1.06031705
88MP0001756_abnormal_urination1.03959639
89MP0003634_abnormal_glial_cell1.02768999
90MP0005395_other_phenotype1.00696048
91MP0005451_abnormal_body_composition0.99555286
92MP0002837_dystrophic_cardiac_calcinosis0.99073857
93MP0004145_abnormal_muscle_electrophysio0.97731660
94MP0001502_abnormal_circadian_rhythm0.97470034
95MP0002882_abnormal_neuron_morphology0.96134924
96MP0002160_abnormal_reproductive_system0.96095586
97MP0003137_abnormal_impulse_conducting0.94849037
98MP0000358_abnormal_cell_content/0.94173713
99MP0002751_abnormal_autonomic_nervous0.93948135
100MP0003631_nervous_system_phenotype0.93426898
101MP0000955_abnormal_spinal_cord0.92754019
102MP0005551_abnormal_eye_electrophysiolog0.92361197
103MP0005535_abnormal_body_temperature0.90556102
104MP0005167_abnormal_blood-brain_barrier0.89921937
105MP0009780_abnormal_chondrocyte_physiolo0.89900199
106MP0000747_muscle_weakness0.89317879
107MP0005058_abnormal_lysosome_morphology0.88996749
108MP0001963_abnormal_hearing_physiology0.88299634
109MP0000631_abnormal_neuroendocrine_gland0.88066518
110MP0005389_reproductive_system_phenotype0.86703751
111MP0008058_abnormal_DNA_repair0.86671226
112MP0002752_abnormal_somatic_nervous0.86587747
113MP0006292_abnormal_olfactory_placode0.85823558
114MP0008995_early_reproductive_senescence0.85642822
115MP0003950_abnormal_plasma_membrane0.85472231
116MP0000569_abnormal_digit_pigmentation0.84830019
117MP0002090_abnormal_vision0.84798464
118MP0003632_abnormal_nervous_system0.84443969
119MP0002557_abnormal_social/conspecific_i0.83960980
120MP0005645_abnormal_hypothalamus_physiol0.81727472
121MP0005410_abnormal_fertilization0.81710650
122MP0000372_irregular_coat_pigmentation0.80225107
123MP0004381_abnormal_hair_follicle0.80124438
124MP0005187_abnormal_penis_morphology0.79859691
125MP0004085_abnormal_heartbeat0.79651895
126MP0002069_abnormal_eating/drinking_beha0.79016026
127MP0004484_altered_response_of0.76684290
128MP0003186_abnormal_redox_activity0.76290638
129MP0003690_abnormal_glial_cell0.75417655
130MP0004019_abnormal_vitamin_homeostasis0.74979304
131MP0008569_lethality_at_weaning0.74555923
132MP0002152_abnormal_brain_morphology0.73760300
133MP0001764_abnormal_homeostasis0.72729566
134MP0003122_maternal_imprinting0.72710910
135MP0009379_abnormal_foot_pigmentation0.72683442
136MP0000026_abnormal_inner_ear0.72348731
137MP0002277_abnormal_respiratory_mucosa0.69653432

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)4.80604119
2Acute necrotizing encephalopathy (HP:0006965)4.19122162
3Febrile seizures (HP:0002373)4.10895884
4Mitochondrial inheritance (HP:0001427)3.72919989
5Abnormal mitochondria in muscle tissue (HP:0008316)3.65537143
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.64109465
7Hepatocellular necrosis (HP:0001404)3.45024766
83-Methylglutaconic aciduria (HP:0003535)3.38267114
9Progressive macrocephaly (HP:0004481)3.36174645
10CNS hypomyelination (HP:0003429)3.36084903
11Acute encephalopathy (HP:0006846)3.28950867
12Increased CSF lactate (HP:0002490)3.27283806
13Delusions (HP:0000746)3.23436532
14Epileptic encephalopathy (HP:0200134)3.23043811
15Hepatic necrosis (HP:0002605)3.13853301
16Breast hypoplasia (HP:0003187)3.12111721
17Increased hepatocellular lipid droplets (HP:0006565)3.08958496
18Action tremor (HP:0002345)3.06624026
19Progressive cerebellar ataxia (HP:0002073)2.88040537
20Carpal bone hypoplasia (HP:0001498)2.85041397
21Nephrogenic diabetes insipidus (HP:0009806)2.84849702
22Increased serum pyruvate (HP:0003542)2.80522619
23Abnormality of glycolysis (HP:0004366)2.80522619
24Myokymia (HP:0002411)2.79810064
25Dysautonomia (HP:0002459)2.78719713
26Hemiparesis (HP:0001269)2.71613992
27Abnormal eating behavior (HP:0100738)2.71038620
28Birth length less than 3rd percentile (HP:0003561)2.69846031
29CNS demyelination (HP:0007305)2.67762378
30Focal motor seizures (HP:0011153)2.67301684
31Hypothermia (HP:0002045)2.66020841
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63106203
33Congenital ichthyosiform erythroderma (HP:0007431)2.60120904
34Lipid accumulation in hepatocytes (HP:0006561)2.59358682
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59219873
36Split foot (HP:0001839)2.57690522
37Generalized tonic-clonic seizures (HP:0002069)2.53999367
38Abnormal autonomic nervous system physiology (HP:0012332)2.49579675
39True hermaphroditism (HP:0010459)2.48819195
40Rough bone trabeculation (HP:0100670)2.48307417
41Hyperglycinemia (HP:0002154)2.47150777
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.47137862
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.47137862
44Respiratory failure (HP:0002878)2.46140031
45Increased serum lactate (HP:0002151)2.44847365
46Renal Fanconi syndrome (HP:0001994)2.43534268
47Emotional lability (HP:0000712)2.42505040
48Spastic paraparesis (HP:0002313)2.40828207
49Epileptiform EEG discharges (HP:0011182)2.40625653
50Aplasia/hypoplasia of the uterus (HP:0008684)2.39783980
51Intention tremor (HP:0002080)2.38584766
52Abnormality of the umbilical cord (HP:0010881)2.38198562
53Leukodystrophy (HP:0002415)2.37475498
54EEG with generalized epileptiform discharges (HP:0011198)2.36965203
55Lactic acidosis (HP:0003128)2.35006500
56Broad-based gait (HP:0002136)2.33553077
57Postnatal microcephaly (HP:0005484)2.33183973
58Methylmalonic acidemia (HP:0002912)2.32990522
59Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31912005
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31912005
61Hypsarrhythmia (HP:0002521)2.30950386
62Abnormality of midbrain morphology (HP:0002418)2.29778996
63Molar tooth sign on MRI (HP:0002419)2.29778996
64Abnormality of the labia minora (HP:0012880)2.29632836
65Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.26996952
66Genital tract atresia (HP:0001827)2.26869363
67Abnormality of alanine metabolism (HP:0010916)2.26625306
68Hyperalaninemia (HP:0003348)2.26625306
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26625306
70Impaired vibration sensation in the lower limbs (HP:0002166)2.25330664
71Prolonged neonatal jaundice (HP:0006579)2.22615544
72Cerebral edema (HP:0002181)2.22553172
73Neuroendocrine neoplasm (HP:0100634)2.21997231
74Pheochromocytoma (HP:0002666)2.21508277
75Gaze-evoked nystagmus (HP:0000640)2.20387099
76Parakeratosis (HP:0001036)2.19402047
77Vaginal atresia (HP:0000148)2.18585962
78Aplasia/Hypoplasia involving the musculature (HP:0001460)2.18265207
79Pancreatic fibrosis (HP:0100732)2.15805332
80Agitation (HP:0000713)2.15487785
81Dysdiadochokinesis (HP:0002075)2.14634547
82Abnormality of the corticospinal tract (HP:0002492)2.14592250
83Dialeptic seizures (HP:0011146)2.12321823
84Amyotrophic lateral sclerosis (HP:0007354)2.12300618
85Specific learning disability (HP:0001328)2.10232073
86Secondary amenorrhea (HP:0000869)2.08122442
87Limb dystonia (HP:0002451)2.06920443
88Optic disc pallor (HP:0000543)2.06484944
89Unsteady gait (HP:0002317)2.04951568
90Atrophy/Degeneration involving motor neurons (HP:0007373)2.04569327
91Postural tremor (HP:0002174)2.04093536
92Mutism (HP:0002300)2.03964671
93Brittle hair (HP:0002299)2.02695521
94Lethargy (HP:0001254)2.02061337
95Atonic seizures (HP:0010819)2.00786939
96Hypoglycemic coma (HP:0001325)2.00088255
97Abnormal respiratory epithelium morphology (HP:0012253)1.99495077
98Abnormal respiratory motile cilium morphology (HP:0005938)1.99495077
99Abnormal ciliary motility (HP:0012262)1.99142352
100Hyperventilation (HP:0002883)1.99099489
101Patent foramen ovale (HP:0001655)1.98128320
102Amblyopia (HP:0000646)1.97873463
103Nephronophthisis (HP:0000090)1.96427484
104Ureteral duplication (HP:0000073)1.96424726
105Methylmalonic aciduria (HP:0012120)1.93430571
106Abnormal trabecular bone morphology (HP:0100671)1.92812984
107Exertional dyspnea (HP:0002875)1.92569207
108Muscular hypotonia of the trunk (HP:0008936)1.91465602
109Microvesicular hepatic steatosis (HP:0001414)1.90898780
110Exercise intolerance (HP:0003546)1.89066379
111Abnormal hair whorl (HP:0010721)1.87579696
112Death in infancy (HP:0001522)1.87340709
113Pancreatic cysts (HP:0001737)1.87320284
114Polyphagia (HP:0002591)1.86334440
115Focal dystonia (HP:0004373)1.86115917
116Abnormal respiratory motile cilium physiology (HP:0012261)1.85914328
117Retinal dysplasia (HP:0007973)1.85734355
118Abolished electroretinogram (ERG) (HP:0000550)1.85459006
119Medial flaring of the eyebrow (HP:0010747)1.84194433
120Absence seizures (HP:0002121)1.84148134
121Abnormality of liposaccharide metabolism (HP:0010968)1.82944911
122Abnormality of glycosphingolipid metabolism (HP:0004343)1.82944911
123Abnormality of glycolipid metabolism (HP:0010969)1.82944911
124Gait imbalance (HP:0002141)1.82536761
125Gout (HP:0001997)1.82114249
126External ophthalmoplegia (HP:0000544)1.81628433
127Segmental peripheral demyelination/remyelination (HP:0003481)1.80584057
128Peripheral hypomyelination (HP:0007182)1.80425701
129Increased muscle lipid content (HP:0009058)1.80300101
130Abnormal pupillary function (HP:0007686)1.79925479
131Failure to thrive in infancy (HP:0001531)1.79609081
132Spastic tetraplegia (HP:0002510)1.78761359
133Restlessness (HP:0000711)1.78758946
134Megaloblastic anemia (HP:0001889)1.78586065
135X-linked dominant inheritance (HP:0001423)1.78428152
136Hypoplasia of the uterus (HP:0000013)1.78175251
137Absent hand (HP:0004050)1.77936770
138Anxiety (HP:0000739)1.77637815
139Generalized aminoaciduria (HP:0002909)1.77230885
140Hypomagnesemia (HP:0002917)1.76975777
141Poor suck (HP:0002033)1.76897714
142Lissencephaly (HP:0001339)1.76810132
143Ankle clonus (HP:0011448)1.76570891
144Poor coordination (HP:0002370)1.74925366
145Abnormalities of placenta or umbilical cord (HP:0001194)1.73632858
146Left ventricular hypertrophy (HP:0001712)1.72253299
147Pachygyria (HP:0001302)1.72176226
148Hyperglycinuria (HP:0003108)1.72127893
149Abnormality of renal resorption (HP:0011038)1.71882238
150Irregular epiphyses (HP:0010582)1.71874807
151Congenital primary aphakia (HP:0007707)1.71637854
152Increased intramyocellular lipid droplets (HP:0012240)1.71277665
153Congenital stationary night blindness (HP:0007642)1.70244973
154Muscle fiber splitting (HP:0003555)1.70023529
155Athetosis (HP:0002305)1.69532085
156Double outlet right ventricle (HP:0001719)1.69288934
157Congenital malformation of the right heart (HP:0011723)1.69288934
158Focal seizures (HP:0007359)1.69134490

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.82694804
2BUB14.23947716
3STK163.52712385
4WEE13.51334037
5MAP4K23.15777413
6TSSK63.06356726
7EPHA22.95482288
8ARAF2.90547701
9AKT32.82681106
10NME12.49188458
11TRIM282.48856432
12FRK2.17920126
13MARK11.91810958
14MAP3K121.86130785
15EIF2AK11.80685571
16EIF2AK31.67793243
17STK391.65714462
18PLK41.61554433
19DAPK21.59857888
20ERBB31.56405509
21SRPK11.56111605
22BRAF1.53675124
23PAK31.53308728
24OXSR11.52221724
25BCR1.51361055
26NTRK21.46994380
27CASK1.32900935
28GRK51.32328113
29PHKG21.30241134
30PHKG11.30241134
31MST41.30150177
32NME21.30121002
33PLK31.27300727
34GRK11.25520082
35TESK21.25009122
36PINK11.19775972
37CSNK1G31.18377487
38WNK31.15931416
39DYRK21.15818058
40CAMK2B1.12132909
41EPHA31.10957135
42ZAK1.10614078
43TESK11.08594848
44BCKDK1.08052261
45MAP2K41.04924954
46IRAK31.04186064
47VRK11.02472722
48NTRK30.99139782
49MAP3K90.98109681
50LIMK10.93959092
51AURKA0.93698390
52PAK60.92399600
53CCNB10.91670595
54CDK190.90670593
55CAMK2G0.90204711
56NTRK10.89873876
57MAPKAPK50.88957240
58CAMK2D0.86967214
59BRSK20.86501851
60TAOK30.85872899
61PRKCG0.85611944
62PDK20.84724777
63CSNK1G20.83981036
64INSRR0.83921526
65GRK70.81866382
66MYLK0.81609596
67NEK10.81418802
68CSNK1G10.81284980
69PIM20.81054212
70EPHA40.80633758
71WNK40.79797222
72PDK30.78533240
73PDK40.78533240
74DYRK30.76374422
75IRAK20.75909565
76TTK0.75222809
77PRKCI0.74329512
78PLK20.72747433
79CSNK1A1L0.71582093
80BRSK10.71383816
81PBK0.71177128
82PLK10.70598319
83CAMKK20.68823671
84MAPK150.68723655
85PTK2B0.66352698
86MAP2K70.65527913
87TNIK0.65170911
88PRKG10.64451924
89CDK140.63384245
90DAPK10.63256507
91ADRBK20.62103931
92ADRBK10.60139403
93PRKCE0.58326823
94NEK60.54749416
95PAK10.54146818
96MAP3K50.53754490
97CAMK2A0.53169042
98MKNK20.52668759
99SIK30.52556426
100IRAK10.52150479
101SGK20.52031444
102KSR10.51409468
103TLK10.50796259
104PRKCZ0.50585308
105MINK10.48746327
106CSNK1E0.48354504
107MAPK130.48345495
108RPS6KA50.47323395
109DYRK1B0.47322355
110CDK180.47139885
111CAMK10.46675285
112CDK150.45842955
113UHMK10.45635647
114MAP2K20.45381069
115OBSCN0.44450124
116PRKCA0.43686954
117MAP3K40.43055161
118CSNK1A10.42992341
119CDK11A0.42708758
120RPS6KA40.41899245
121FER0.40997274
122CSNK2A20.40705547
123ABL20.40598644
124CSNK2A10.40527750
125PKN10.40504338
126TIE10.40297823
127SGK2230.39879215
128SGK4940.39879215
129BMPR1B0.38659048
130BMPR20.37299644
131DAPK30.36523184
132CSNK1D0.36041076
133FGFR20.35372794
134CDK50.34948322
135ROCK20.34359600
136MKNK10.34221029
137PRKACG0.32840697
138PRKACA0.32432568
139DYRK1A0.32372216
140PRKACB0.30046294
141CAMK40.27065013
142MUSK0.26699012
143SGK10.26632335

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.43920958
2Oxidative phosphorylation_Homo sapiens_hsa001904.10294831
3RNA polymerase_Homo sapiens_hsa030203.89304235
4Vitamin B6 metabolism_Homo sapiens_hsa007503.58522392
5Parkinsons disease_Homo sapiens_hsa050123.30152620
6Collecting duct acid secretion_Homo sapiens_hsa049662.70077183
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.59096744
8Huntingtons disease_Homo sapiens_hsa050162.55093431
9Protein export_Homo sapiens_hsa030602.50937589
10Ribosome_Homo sapiens_hsa030102.44460344
11Alzheimers disease_Homo sapiens_hsa050102.35602120
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15457229
13* Regulation of autophagy_Homo sapiens_hsa041401.99798892
14Synaptic vesicle cycle_Homo sapiens_hsa047211.95016105
15Pyrimidine metabolism_Homo sapiens_hsa002401.78034176
16Nitrogen metabolism_Homo sapiens_hsa009101.73907902
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.67387917
18Vibrio cholerae infection_Homo sapiens_hsa051101.65285611
19Folate biosynthesis_Homo sapiens_hsa007901.55154615
20RNA transport_Homo sapiens_hsa030131.52291316
21Nicotine addiction_Homo sapiens_hsa050331.51540954
22Basal transcription factors_Homo sapiens_hsa030221.44077793
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43229247
24Fatty acid elongation_Homo sapiens_hsa000621.41528685
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38863826
26Cardiac muscle contraction_Homo sapiens_hsa042601.33767250
27Purine metabolism_Homo sapiens_hsa002301.30928720
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.26730483
29Spliceosome_Homo sapiens_hsa030401.26095513
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21122211
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20223322
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11740150
33Sphingolipid metabolism_Homo sapiens_hsa006001.07821868
34Fructose and mannose metabolism_Homo sapiens_hsa000511.06918527
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02549738
36Cholinergic synapse_Homo sapiens_hsa047251.00030368
37Nucleotide excision repair_Homo sapiens_hsa034200.99501960
38SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99249860
39Salivary secretion_Homo sapiens_hsa049700.98569089
40Renin secretion_Homo sapiens_hsa049240.98460007
41Ether lipid metabolism_Homo sapiens_hsa005650.97929810
42Phototransduction_Homo sapiens_hsa047440.96844645
43Gastric acid secretion_Homo sapiens_hsa049710.94716138
44Steroid biosynthesis_Homo sapiens_hsa001000.92962960
45Pentose phosphate pathway_Homo sapiens_hsa000300.92852799
46Peroxisome_Homo sapiens_hsa041460.92640327
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92021279
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89978324
49Propanoate metabolism_Homo sapiens_hsa006400.87751420
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87661854
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86728861
52Metabolic pathways_Homo sapiens_hsa011000.85983492
53Taste transduction_Homo sapiens_hsa047420.85906810
54Oocyte meiosis_Homo sapiens_hsa041140.84677112
55Gap junction_Homo sapiens_hsa045400.84088658
56Rheumatoid arthritis_Homo sapiens_hsa053230.79253245
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77526410
58Homologous recombination_Homo sapiens_hsa034400.76930291
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76039739
60Linoleic acid metabolism_Homo sapiens_hsa005910.75765409
61Amphetamine addiction_Homo sapiens_hsa050310.75733506
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75603420
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.74915502
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74849036
65Sulfur metabolism_Homo sapiens_hsa009200.74058740
66Calcium signaling pathway_Homo sapiens_hsa040200.73945952
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.73357039
68Serotonergic synapse_Homo sapiens_hsa047260.72952221
69Glutathione metabolism_Homo sapiens_hsa004800.72534880
70beta-Alanine metabolism_Homo sapiens_hsa004100.70434311
71Arachidonic acid metabolism_Homo sapiens_hsa005900.70293715
72* GABAergic synapse_Homo sapiens_hsa047270.69536968
73Epstein-Barr virus infection_Homo sapiens_hsa051690.69366640
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68919277
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67733213
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66307369
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65833685
78Butanoate metabolism_Homo sapiens_hsa006500.65573377
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65104461
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64816241
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63567398
82Oxytocin signaling pathway_Homo sapiens_hsa049210.60777114
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59516139
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58968160
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58949402
86Arginine and proline metabolism_Homo sapiens_hsa003300.57709398
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.57324058
88Mismatch repair_Homo sapiens_hsa034300.57098939
89Pancreatic secretion_Homo sapiens_hsa049720.52538105
90cAMP signaling pathway_Homo sapiens_hsa040240.52235724
91Morphine addiction_Homo sapiens_hsa050320.50765413
92Lysosome_Homo sapiens_hsa041420.50468317
93Alcoholism_Homo sapiens_hsa050340.49786848
94Glutamatergic synapse_Homo sapiens_hsa047240.48779401
95Circadian rhythm_Homo sapiens_hsa047100.48762459
96Vitamin digestion and absorption_Homo sapiens_hsa049770.48748218
97Cocaine addiction_Homo sapiens_hsa050300.47390578
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45761281
99Type I diabetes mellitus_Homo sapiens_hsa049400.45194071
100Dopaminergic synapse_Homo sapiens_hsa047280.45034106
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43461492
102Cell cycle_Homo sapiens_hsa041100.40033219
103Insulin secretion_Homo sapiens_hsa049110.38470451
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38164423
105Fatty acid metabolism_Homo sapiens_hsa012120.37919442
106Circadian entrainment_Homo sapiens_hsa047130.37035434
107RNA degradation_Homo sapiens_hsa030180.36675359
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36171176
109Tryptophan metabolism_Homo sapiens_hsa003800.35605971
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35437726
111Axon guidance_Homo sapiens_hsa043600.34910844
112Mineral absorption_Homo sapiens_hsa049780.34467104
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34434993
114Olfactory transduction_Homo sapiens_hsa047400.33915801
115Long-term potentiation_Homo sapiens_hsa047200.33063932
116Histidine metabolism_Homo sapiens_hsa003400.31458117
117Long-term depression_Homo sapiens_hsa047300.31104251
118DNA replication_Homo sapiens_hsa030300.30994699
119Carbon metabolism_Homo sapiens_hsa012000.30905195
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30559464
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.29878463
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.29840217
123Phagosome_Homo sapiens_hsa041450.29276969
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28044142
125Fanconi anemia pathway_Homo sapiens_hsa034600.27697679
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27515075
127Tyrosine metabolism_Homo sapiens_hsa003500.25287496
128Type II diabetes mellitus_Homo sapiens_hsa049300.25147126
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23342215
130Base excision repair_Homo sapiens_hsa034100.22727445
131Tight junction_Homo sapiens_hsa045300.22286281
132Chemical carcinogenesis_Homo sapiens_hsa052040.22155325
133Ras signaling pathway_Homo sapiens_hsa040140.20958703
134Endocytosis_Homo sapiens_hsa041440.20737494
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19856972
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18659058

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