GABPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.49147754
2nuclear pore organization (GO:0006999)5.37445989
3protein localization to kinetochore (GO:0034501)4.52362613
4regulation of spindle organization (GO:0090224)4.43895490
5mitotic metaphase plate congression (GO:0007080)4.36947163
6pore complex assembly (GO:0046931)4.11544383
7mitotic sister chromatid cohesion (GO:0007064)4.10551194
8mitotic nuclear envelope disassembly (GO:0007077)4.10364435
9regulation of mitotic spindle organization (GO:0060236)4.00294329
10purine nucleobase biosynthetic process (GO:0009113)3.89974066
11protein localization to chromosome, centromeric region (GO:0071459)3.88668861
12regulation of RNA export from nucleus (GO:0046831)3.85068671
13nuclear envelope disassembly (GO:0051081)3.84727317
14membrane disassembly (GO:0030397)3.84727317
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.80670227
16positive regulation of chromosome segregation (GO:0051984)3.76471300
17metaphase plate congression (GO:0051310)3.74141011
18mitotic chromosome condensation (GO:0007076)3.72979040
19nucleobase biosynthetic process (GO:0046112)3.72399897
20negative regulation of DNA repair (GO:0045738)3.65785703
21folic acid-containing compound biosynthetic process (GO:0009396)3.61435366
22ribosome assembly (GO:0042255)3.57005290
23DNA unwinding involved in DNA replication (GO:0006268)3.47876753
24positive regulation of mitotic sister chromatid separation (GO:1901970)3.45675355
25positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.45675355
26positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.45675355
27ether lipid metabolic process (GO:0046485)3.45454649
28sister chromatid cohesion (GO:0007062)3.44427883
29folic acid metabolic process (GO:0046655)3.41490272
30DNA topological change (GO:0006265)3.39837920
31regulation of DNA endoreduplication (GO:0032875)3.32476413
32sister chromatid segregation (GO:0000819)3.30328792
33glycine metabolic process (GO:0006544)3.29332735
34monoubiquitinated protein deubiquitination (GO:0035520)3.28446276
35IMP biosynthetic process (GO:0006188)3.24374906
36regulation of sister chromatid cohesion (GO:0007063)3.23892350
37DNA replication-dependent nucleosome assembly (GO:0006335)3.22074239
38DNA replication-dependent nucleosome organization (GO:0034723)3.22074239
39mitotic sister chromatid segregation (GO:0000070)3.16671909
40negative regulation of histone methylation (GO:0031061)3.15871133
41kinetochore organization (GO:0051383)3.14453592
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.13675612
43DNA replication checkpoint (GO:0000076)3.12961468
44negative regulation of fibroblast apoptotic process (GO:2000270)3.12665183
45regulation of centriole replication (GO:0046599)3.11789131
46double-strand break repair via nonhomologous end joining (GO:0006303)3.11533036
47non-recombinational repair (GO:0000726)3.11533036
48DNA replication initiation (GO:0006270)3.11413654
49nuclear envelope organization (GO:0006998)3.10821697
50regulation of meiosis I (GO:0060631)3.09850256
51N-terminal protein amino acid acetylation (GO:0006474)3.09719797
52establishment of chromosome localization (GO:0051303)3.08459239
53mitotic G2/M transition checkpoint (GO:0044818)3.07999795
54attachment of spindle microtubules to kinetochore (GO:0008608)3.06773097
55regulation of chromosome segregation (GO:0051983)3.03294514
56regulation of translational termination (GO:0006449)3.02885603
57histone H2A monoubiquitination (GO:0035518)3.01592666
58nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.01219696
59DNA geometric change (GO:0032392)3.00619426
60DNA duplex unwinding (GO:0032508)3.00463597
61definitive hemopoiesis (GO:0060216)3.00419374
62regulation of histone H3-K9 methylation (GO:0051570)3.00319555
63regulation of nucleobase-containing compound transport (GO:0032239)2.97676061
64formation of translation preinitiation complex (GO:0001731)2.97466084
65negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.97332715
66neural tube formation (GO:0001841)2.96980645
67protein localization to chromosome (GO:0034502)2.95246664
68pre-miRNA processing (GO:0031054)2.93439517
69regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.93125026
70response to UV-C (GO:0010225)2.90504670
71spindle checkpoint (GO:0031577)2.90272496
72negative regulation of mRNA processing (GO:0050686)2.89831813
73regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89109013
74DNA synthesis involved in DNA repair (GO:0000731)2.88557225
75negative regulation of mRNA metabolic process (GO:1903312)2.88357043
76heterochromatin organization (GO:0070828)2.87407090
77IMP metabolic process (GO:0046040)2.86121640
78regulation of helicase activity (GO:0051095)2.83841949
79positive regulation of histone H3-K4 methylation (GO:0051571)2.81625682
80cellular protein complex localization (GO:0034629)2.80329280
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.79919220
82NLS-bearing protein import into nucleus (GO:0006607)2.79529166
83chromatin remodeling at centromere (GO:0031055)2.79415077
84mitotic recombination (GO:0006312)2.78860540
85DNA double-strand break processing (GO:0000729)2.78049698
86positive regulation of SMAD protein import into nucleus (GO:0060391)2.77397408
87mitotic G2 DNA damage checkpoint (GO:0007095)2.77101110
88mRNA transport (GO:0051028)2.76415262
89DNA replication-independent nucleosome assembly (GO:0006336)2.76249557
90DNA replication-independent nucleosome organization (GO:0034724)2.76249557
91nucleus organization (GO:0006997)2.75697585
92regulation of centrosome cycle (GO:0046605)2.72777609
93CENP-A containing nucleosome assembly (GO:0034080)2.72478965
94negative regulation of RNA splicing (GO:0033119)2.72005982
95paraxial mesoderm development (GO:0048339)2.70748920
96negative regulation of DNA-dependent DNA replication (GO:2000104)2.70551132
97negative regulation of chromosome segregation (GO:0051985)2.70246179
98mitotic spindle checkpoint (GO:0071174)2.69959641
99spindle assembly checkpoint (GO:0071173)2.69806295
100ribosome biogenesis (GO:0042254)2.68929106
101telomere maintenance via semi-conservative replication (GO:0032201)2.68424697
102chromatin assembly or disassembly (GO:0006333)2.66753498
103histone-serine phosphorylation (GO:0035404)2.66389437
104regulation of DNA damage checkpoint (GO:2000001)2.65994767
105negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.65827575
106DNA strand elongation (GO:0022616)2.65796671
107negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.64813372
108negative regulation of sister chromatid segregation (GO:0033046)2.64813372
109negative regulation of mitotic sister chromatid separation (GO:2000816)2.64813372
110negative regulation of mitotic sister chromatid segregation (GO:0033048)2.64813372
111mitotic spindle assembly checkpoint (GO:0007094)2.64425557
112regulation of mitotic sister chromatid separation (GO:0010965)2.63313679
113regulation of mitotic sister chromatid segregation (GO:0033047)2.63313679
114regulation of sister chromatid segregation (GO:0033045)2.63313679
115dosage compensation (GO:0007549)2.62762057
116telomere maintenance via recombination (GO:0000722)2.62261790
117protein K6-linked ubiquitination (GO:0085020)2.62174396
118negative regulation of cell cycle G2/M phase transition (GO:1902750)2.61811180
119serine family amino acid biosynthetic process (GO:0009070)2.61377940
120embryonic process involved in female pregnancy (GO:0060136)2.60082559
121establishment of integrated proviral latency (GO:0075713)2.59675667
122DNA strand elongation involved in DNA replication (GO:0006271)2.58454292
123kinetochore assembly (GO:0051382)2.58195313
124chromosome segregation (GO:0007059)2.57229259
125histone exchange (GO:0043486)2.56801769
126meiotic chromosome segregation (GO:0045132)2.56532419
127regulation of translational fidelity (GO:0006450)2.56111681
128regulation of gene silencing by RNA (GO:0060966)2.55462493
129regulation of posttranscriptional gene silencing (GO:0060147)2.55462493
130regulation of gene silencing by miRNA (GO:0060964)2.55462493
131positive regulation of protein import into nucleus, translocation (GO:0033160)2.55433135
132serine family amino acid catabolic process (GO:0009071)2.54302066
133tetrahydrofolate metabolic process (GO:0046653)2.53960560
134negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.53635276
135DNA conformation change (GO:0071103)2.53266442
136chromatin assembly (GO:0031497)2.53100828
137somatic hypermutation of immunoglobulin genes (GO:0016446)2.52145050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.66726169
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.11796980
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.52295068
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.13214000
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.09231395
6* EGR1_19374776_ChIP-ChIP_THP-1_Human2.99663888
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97210250
8AR_21909140_ChIP-Seq_LNCAP_Human2.75921484
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.50859963
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.43319913
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35768263
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.27530145
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.25869485
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23091487
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13470750
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10601109
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.07142297
18FUS_26573619_Chip-Seq_HEK293_Human2.05897376
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00771228
20MYC_22102868_ChIP-Seq_BL_Human1.96814751
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.92780594
22WT1_19549856_ChIP-ChIP_CCG9911_Human1.92224409
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92076860
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83154780
25EWS_26573619_Chip-Seq_HEK293_Human1.75539205
26* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73731359
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71184212
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70773538
29* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69683571
30* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69660713
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66174463
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65183591
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65116196
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61513561
35* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52344553
36* XRN2_22483619_ChIP-Seq_HELA_Human1.52194713
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50047587
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48598161
39TAF15_26573619_Chip-Seq_HEK293_Human1.44316924
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43156083
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41677625
42KDM5A_27292631_Chip-Seq_BREAST_Human1.41457361
43PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40895288
44ZNF263_19887448_ChIP-Seq_K562_Human1.40443714
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.40224038
46* EST1_17652178_ChIP-ChIP_JURKAT_Human1.40001454
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.39964108
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.39803543
49CLOCK_20551151_ChIP-Seq_293T_Human1.39614500
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38942500
51IGF1R_20145208_ChIP-Seq_DFB_Human1.38322337
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37800479
53* VDR_23849224_ChIP-Seq_CD4+_Human1.37292533
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36522049
55* ETS1_20019798_ChIP-Seq_JURKAT_Human1.34914544
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34217088
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33373548
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33278169
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.32367012
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30661641
61RXR_22158963_ChIP-Seq_LIVER_Mouse1.29208338
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28186607
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27157069
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26142030
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22635833
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21623772
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21033396
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20794389
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20794389
70KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20794389
71CIITA_25753668_ChIP-Seq_RAJI_Human1.19966369
72* FOXP3_21729870_ChIP-Seq_TREG_Human1.19049878
73* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18432711
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.18423614
75* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15704131
76ELK1_19687146_ChIP-ChIP_HELA_Human1.15152770
77* GABP_17652178_ChIP-ChIP_JURKAT_Human1.15119339
78SALL4_22934838_ChIP-ChIP_CD34+_Human1.12010220
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11985973
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11319474
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09884892
82GABP_19822575_ChIP-Seq_HepG2_Human1.09229575
83TFEB_21752829_ChIP-Seq_HELA_Human1.09183774
84DCP1A_22483619_ChIP-Seq_HELA_Human1.09002691
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08257413
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.07984815
87* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07488046
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07338342
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07116706
90NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07086961
91* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06887684
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04851757
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04574515
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.04562699
95FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04202743
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03732447
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03318343
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03289020
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02291655
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02216236
101* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02197929
102TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01884148
103MYB_26560356_Chip-Seq_TH2_Human1.01728126
104EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01711870
105CHD1_26751641_Chip-Seq_LNCaP_Human1.00106911
106HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99205988
107JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98866425
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98363799
109* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98335206
110TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97523989
111TTF2_22483619_ChIP-Seq_HELA_Human0.97401017
112LXR_22158963_ChIP-Seq_LIVER_Mouse0.96468792
113CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95870726
114MYB_26560356_Chip-Seq_TH1_Human0.95409587
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94894305
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94495562
117HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93424869
118NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93368203
119CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92947722
120KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92473135
121ATF3_27146783_Chip-Seq_COLON_Human0.92097369
122* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92026443
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91961728
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91464537
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91417574
126FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.90887945
127SPI1_23547873_ChIP-Seq_NB4_Human0.90850380
128E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90532351
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90381341
130PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89630390
131SOX17_20123909_ChIP-Seq_XEN_Mouse0.89147780
132TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89144181
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89056416
134EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88879391
135* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87763295
136* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87315475
137BRD4_25478319_ChIP-Seq_HGPS_Human0.87285006
138SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86044060
139ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85195139
140GATA4_21415370_ChIP-Seq_HL-1_Mouse0.84846235
141MYB_21317192_ChIP-Seq_ERMYB_Mouse0.84773040
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84441841
143NOTCH1_21737748_ChIP-Seq_TLL_Human0.84258598
144* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83782416

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.35419164
2MP0003705_abnormal_hypodermis_morpholog3.08423623
3MP0010352_gastrointestinal_tract_polyps3.00581861
4MP0003111_abnormal_nucleus_morphology2.97137885
5MP0010094_abnormal_chromosome_stability2.93972309
6MP0004957_abnormal_blastocyst_morpholog2.80456466
7MP0009697_abnormal_copulation2.77048090
8* MP0003077_abnormal_cell_cycle2.64074467
9MP0010307_abnormal_tumor_latency2.34560861
10MP0003806_abnormal_nucleotide_metabolis2.12423814
11MP0001730_embryonic_growth_arrest2.07339212
12MP0005076_abnormal_cell_differentiation2.06208340
13MP0008007_abnormal_cellular_replicative1.94681325
14* MP0000350_abnormal_cell_proliferation1.82491321
15MP0001672_abnormal_embryogenesis/_devel1.77939838
16MP0005380_embryogenesis_phenotype1.77939838
17MP0003984_embryonic_growth_retardation1.71872571
18MP0002088_abnormal_embryonic_growth/wei1.70720250
19MP0008058_abnormal_DNA_repair1.68767056
20MP0002396_abnormal_hematopoietic_system1.68663366
21MP0002086_abnormal_extraembryonic_tissu1.65034154
22MP0005360_urolithiasis1.65009627
23MP0003763_abnormal_thymus_physiology1.63114690
24MP0002139_abnormal_hepatobiliary_system1.60843360
25MP0003567_abnormal_fetal_cardiomyocyte1.60362893
26MP0009053_abnormal_anal_canal1.52931135
27MP0001697_abnormal_embryo_size1.52738405
28MP0003123_paternal_imprinting1.52092421
29* MP0004197_abnormal_fetal_growth/weight/1.49732158
30MP0005365_abnormal_bile_salt1.48522628
31MP0003566_abnormal_cell_adhesion1.48216468
32MP0005085_abnormal_gallbladder_physiolo1.43326835
33MP0008260_abnormal_autophagy1.42844453
34MP0002084_abnormal_developmental_patter1.41364140
35* MP0008057_abnormal_DNA_replication1.40293323
36MP0004808_abnormal_hematopoietic_stem1.38636212
37MP0010234_abnormal_vibrissa_follicle1.36818230
38MP0002085_abnormal_embryonic_tissue1.34592061
39MP0005023_abnormal_wound_healing1.31912614
40* MP0002080_prenatal_lethality1.31794606
41MP0008932_abnormal_embryonic_tissue1.30945118
42MP0003656_abnormal_erythrocyte_physiolo1.28532054
43MP0005075_abnormal_melanosome_morpholog1.26756773
44* MP0000703_abnormal_thymus_morphology1.20367419
45MP0008438_abnormal_cutaneous_collagen1.20098323
46MP0009840_abnormal_foam_cell1.16666557
47MP0000733_abnormal_muscle_development1.16420835
48MP0000569_abnormal_digit_pigmentation1.16398199
49MP0001293_anophthalmia1.11235586
50MP0005397_hematopoietic_system_phenotyp1.11133828
51MP0001545_abnormal_hematopoietic_system1.11133828
52MP0004185_abnormal_adipocyte_glucose1.10025459
53MP0009672_abnormal_birth_weight1.09305383
54MP0003121_genomic_imprinting1.08344401
55MP0003252_abnormal_bile_duct1.07325912
56MP0000465_gastrointestinal_hemorrhage1.06277871
57MP0004134_abnormal_chest_morphology1.04169675
58MP0002877_abnormal_melanocyte_morpholog1.04097650
59MP0002019_abnormal_tumor_incidence1.02957637
60MP0001915_intracranial_hemorrhage1.01731140
61MP0002166_altered_tumor_susceptibility0.99502694
62MP0004264_abnormal_extraembryonic_tissu0.98202591
63MP0009703_decreased_birth_body0.96118969
64MP0009278_abnormal_bone_marrow0.94514927
65MP0003786_premature_aging0.93732124
66MP0002092_abnormal_eye_morphology0.92489146
67MP0003890_abnormal_embryonic-extraembry0.92154192
68MP0000609_abnormal_liver_physiology0.91593327
69MP0002006_tumorigenesis0.90005845
70MP0010368_abnormal_lymphatic_system0.89547233
71MP0010030_abnormal_orbit_morphology0.89390551
72* MP0005384_cellular_phenotype0.89253297
73MP0004215_abnormal_myocardial_fiber0.88379320
74MP0000313_abnormal_cell_death0.88346949
75MP0003221_abnormal_cardiomyocyte_apopto0.87666352
76* MP0002398_abnormal_bone_marrow0.87564415
77MP0003937_abnormal_limbs/digits/tail_de0.85570919
78MP0000598_abnormal_liver_morphology0.85350124
79MP0000428_abnormal_craniofacial_morphol0.84255271
80MP0003300_gastrointestinal_ulcer0.84172753
81MP0000490_abnormal_crypts_of0.84155546
82MP0003828_pulmonary_edema0.84114535
83MP0001849_ear_inflammation0.84041618
84MP0003718_maternal_effect0.83725365
85MP0001188_hyperpigmentation0.83241934
86MP0001661_extended_life_span0.81736932
87MP0010630_abnormal_cardiac_muscle0.81688893
88MP0003941_abnormal_skin_development0.81467361
89MP0003787_abnormal_imprinting0.80799379
90MP0006054_spinal_hemorrhage0.80131634
91MP0003091_abnormal_cell_migration0.80129272
92MP0005666_abnormal_adipose_tissue0.79463531
93MP0008877_abnormal_DNA_methylation0.79250678
94MP0002638_abnormal_pupillary_reflex0.78963220
95MP0002925_abnormal_cardiovascular_devel0.78302960
96MP0000537_abnormal_urethra_morphology0.77964190
97MP0004084_abnormal_cardiac_muscle0.76188983
98MP0001286_abnormal_eye_development0.76146948
99MP0009333_abnormal_splenocyte_physiolog0.75367054
100MP0001177_atelectasis0.75001097
101MP0005275_abnormal_skin_tensile0.74873724
102MP0010329_abnormal_lipoprotein_level0.74330885
103MP0000372_irregular_coat_pigmentation0.74156773
104MP0005187_abnormal_penis_morphology0.73835502
105MP0010678_abnormal_skin_adnexa0.73309202
106* MP0002722_abnormal_immune_system0.71712891
107MP0000689_abnormal_spleen_morphology0.70784022
108MP0003453_abnormal_keratinocyte_physiol0.70701040
109MP0000750_abnormal_muscle_regeneration0.70049796
110MP0002111_abnormal_tail_morphology0.69856988
111MP0002269_muscular_atrophy0.69444247
112MP0002060_abnormal_skin_morphology0.68749554
113MP0001929_abnormal_gametogenesis0.68365794
114MP0000383_abnormal_hair_follicle0.68195026
115MP0005409_darkened_coat_color0.68169995
116MP0003448_altered_tumor_morphology0.68150765
117MP0003935_abnormal_craniofacial_develop0.67680775
118MP0000266_abnormal_heart_morphology0.67135207
119MP0000432_abnormal_head_morphology0.66828657
120MP0001145_abnormal_male_reproductive0.66813609
121* MP0005621_abnormal_cell_physiology0.66795412
122MP0000627_abnormal_mammary_gland0.66542259
123MP0000377_abnormal_hair_follicle0.66294870
124MP0009115_abnormal_fat_cell0.65955358
125MP0005171_absent_coat_pigmentation0.65654013
126MP0005464_abnormal_platelet_physiology0.64375753
127MP0003724_increased_susceptibility_to0.63826123
128MP0005408_hypopigmentation0.63028877
129MP0001243_abnormal_dermal_layer0.62966029
130MP0002009_preneoplasia0.62545642
131MP0003943_abnormal_hepatobiliary_system0.62542507
132MP0002210_abnormal_sex_determination0.62101385
133MP0000358_abnormal_cell_content/0.61979880
134MP0002697_abnormal_eye_size0.61132254
135MP0002102_abnormal_ear_morphology0.61039196
136MP0006035_abnormal_mitochondrial_morpho0.60847911
137MP0000015_abnormal_ear_pigmentation0.60795893
138MP0000013_abnormal_adipose_tissue0.60245832
139MP0002233_abnormal_nose_morphology0.60143344
140MP0001851_eye_inflammation0.59785948

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)5.32715318
2Thyroid carcinoma (HP:0002890)3.88538012
3Long clavicles (HP:0000890)3.65794229
4Termporal pattern (HP:0011008)3.40348526
5Insidious onset (HP:0003587)3.40348526
6Ependymoma (HP:0002888)3.15830753
7Curly hair (HP:0002212)3.14047958
8Syringomyelia (HP:0003396)3.05530958
9Spinal cord lesions (HP:0100561)3.05530958
10Birth length less than 3rd percentile (HP:0003561)3.01312161
11Nephroblastoma (Wilms tumor) (HP:0002667)2.91155870
12Progressive external ophthalmoplegia (HP:0000590)2.91005739
13Deep philtrum (HP:0002002)2.85949731
14Cystic hygroma (HP:0000476)2.85878669
15Embryonal renal neoplasm (HP:0011794)2.85051417
16Transitional cell carcinoma of the bladder (HP:0006740)2.76744258
17Impulsivity (HP:0100710)2.74087660
18Subacute progressive viral hepatitis (HP:0006572)2.72307117
19Colon cancer (HP:0003003)2.65853475
20Subaortic stenosis (HP:0001682)2.64750638
21Abnormality of the left ventricular outflow tract (HP:0011103)2.64750638
22Rhabdomyosarcoma (HP:0002859)2.59042178
23Bladder neoplasm (HP:0009725)2.58463652
24Bladder carcinoma (HP:0002862)2.58463652
25Hyperglycinemia (HP:0002154)2.52757543
26Ankle contracture (HP:0006466)2.52470621
27Deviation of the thumb (HP:0009603)2.51228612
28Biliary tract neoplasm (HP:0100574)2.51085090
29Volvulus (HP:0002580)2.50718170
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.49915979
31Short 4th metacarpal (HP:0010044)2.49915979
32Proximal placement of thumb (HP:0009623)2.49212130
33Abnormality of the astrocytes (HP:0100707)2.48577519
34Astrocytoma (HP:0009592)2.48577519
35Breast hypoplasia (HP:0003187)2.45824389
36Spastic diplegia (HP:0001264)2.39624001
37Medulloblastoma (HP:0002885)2.38895345
38Neoplasm of the colon (HP:0100273)2.38433609
39Hyperglycinuria (HP:0003108)2.37280040
40Selective tooth agenesis (HP:0001592)2.36271889
41Protrusio acetabuli (HP:0003179)2.35825022
42Abnormal auditory evoked potentials (HP:0006958)2.35647994
43Multiple enchondromatosis (HP:0005701)2.34609254
44Truncal obesity (HP:0001956)2.33976847
45Abnormal hair whorl (HP:0010721)2.25897119
46Abnormality of the labia minora (HP:0012880)2.25164530
47Glioma (HP:0009733)2.23611977
48Viral hepatitis (HP:0006562)2.22043761
49Leiomyosarcoma (HP:0100243)2.20968190
50Uterine leiomyosarcoma (HP:0002891)2.20968190
51Abnormality of monocarboxylic acid metabolism (HP:0010996)2.20821809
52IgM deficiency (HP:0002850)2.19917191
53Long eyelashes (HP:0000527)2.19804374
54Neoplasm of the adrenal cortex (HP:0100641)2.18031599
55Prominent nose (HP:0000448)2.14406306
56Malignant gastrointestinal tract tumors (HP:0006749)2.13034618
57Gastrointestinal carcinoma (HP:0002672)2.13034618
58Vertebral arch anomaly (HP:0008438)2.12316519
59Abnormality of the preputium (HP:0100587)2.11508225
60T lymphocytopenia (HP:0005403)2.08360735
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.08067456
62Osteolytic defects of the hand bones (HP:0009699)2.08067456
63Abnormality of serine family amino acid metabolism (HP:0010894)2.06647906
64Abnormality of glycine metabolism (HP:0010895)2.06647906
65Abnormality of the 4th metacarpal (HP:0010012)2.05106175
66Degeneration of the lateral corticospinal tracts (HP:0002314)2.04527908
67Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.04527908
68Abnormal lung lobation (HP:0002101)2.04203664
69Deep venous thrombosis (HP:0002625)2.04091866
70Neoplasm of the oral cavity (HP:0100649)2.03717723
71Abnormality of chromosome stability (HP:0003220)2.02251124
72Shallow orbits (HP:0000586)2.01469830
73Neoplasm of striated muscle (HP:0009728)2.01043191
74Facial hemangioma (HP:0000329)2.00251665
75Menstrual irregularities (HP:0000858)1.99732337
76Patellar aplasia (HP:0006443)1.99368521
77Increased nuchal translucency (HP:0010880)1.98291215
78Chromsome breakage (HP:0040012)1.98057980
79Hypobetalipoproteinemia (HP:0003563)1.96238162
80Autoamputation (HP:0001218)1.95913958
81Sparse lateral eyebrow (HP:0005338)1.95836644
82Spontaneous hematomas (HP:0007420)1.95541098
83Acute myeloid leukemia (HP:0004808)1.94613182
84Hematochezia (HP:0002573)1.94454716
85Small intestinal stenosis (HP:0012848)1.93484772
86Duodenal stenosis (HP:0100867)1.93484772
87Abnormality of pyrimidine metabolism (HP:0004353)1.93207239
88Hypochromic microcytic anemia (HP:0004840)1.92530210
89Basal cell carcinoma (HP:0002671)1.92395479
90Abnormality of sulfur amino acid metabolism (HP:0004339)1.91874203
91Relative macrocephaly (HP:0004482)1.91150239
92Intrahepatic cholestasis (HP:0001406)1.90995189
93Enlarged penis (HP:0000040)1.90855806
94Rimmed vacuoles (HP:0003805)1.89765447
95Submucous cleft hard palate (HP:0000176)1.89687188
96Atresia of the external auditory canal (HP:0000413)1.87927028
97Myocardial infarction (HP:0001658)1.87683014
98Rectal prolapse (HP:0002035)1.87293627
99Aplasia/Hypoplasia of the patella (HP:0006498)1.87063461
100Cortical dysplasia (HP:0002539)1.86483286
101Freckling (HP:0001480)1.85498505
102Abnormality of the fingertips (HP:0001211)1.85195388
103Neoplasm of the pancreas (HP:0002894)1.85102615
104Abnormality of chromosome segregation (HP:0002916)1.84746859
105Agnosia (HP:0010524)1.84509317
106Abnormality of the ileum (HP:0001549)1.84390804
107Overlapping toe (HP:0001845)1.84182563
108Blepharitis (HP:0000498)1.82758248
109Premature rupture of membranes (HP:0001788)1.82654940
110Abnormal cartilage morphology (HP:0002763)1.82533612
111Gonadotropin excess (HP:0000837)1.82336022
112Neoplasm of the thyroid gland (HP:0100031)1.81863810
113Hyperinsulinemic hypoglycemia (HP:0000825)1.81713617
114Increased mean platelet volume (HP:0011877)1.81565150
115Dyschromatopsia (HP:0007641)1.81386050
116Breast carcinoma (HP:0003002)1.81178251
117Ovarian neoplasm (HP:0100615)1.80726599
118Cutaneous melanoma (HP:0012056)1.80155485
119Abnormal biliary tract morphology (HP:0012440)1.79220839
120Abnormal platelet volume (HP:0011876)1.78872133
121Aplasia/Hypoplasia of the uvula (HP:0010293)1.77993828
122Pancreatic islet-cell hyperplasia (HP:0004510)1.77699402
123Oral leukoplakia (HP:0002745)1.77398688
124Sensory axonal neuropathy (HP:0003390)1.77006669
125Pseudobulbar signs (HP:0002200)1.76944543
126Embryonal neoplasm (HP:0002898)1.76239822
127Hypolipoproteinemia (HP:0010981)1.75867851
128Metaphyseal cupping (HP:0003021)1.75720700
129Cutis marmorata (HP:0000965)1.75533833
130Neoplasm of the adrenal gland (HP:0100631)1.75452156
131Amaurosis fugax (HP:0100576)1.74518103
132Cafe-au-lait spot (HP:0000957)1.72473485
133Abnormality of the hip-girdle musculature (HP:0001445)1.72357403
134Abnormality of the musculature of the pelvis (HP:0001469)1.72357403
135Abnormality of the peritoneum (HP:0002585)1.71820782
136Entropion (HP:0000621)1.71030031
137Hypoalphalipoproteinemia (HP:0003233)1.70674329
138Degeneration of anterior horn cells (HP:0002398)1.70527329
139Abnormality of the anterior horn cell (HP:0006802)1.70527329
140Clubbing of toes (HP:0100760)1.70238879
141Carpal bone hypoplasia (HP:0001498)1.69402129
142Esophageal varix (HP:0002040)1.69397020
143Abnormality of serum amino acid levels (HP:0003112)1.69220000
144Uterine neoplasm (HP:0010784)1.68503117
145Sandal gap (HP:0001852)1.68417660
146Fatigue (HP:0012378)1.68340425
147Squamous cell carcinoma (HP:0002860)1.68306650
148Low anterior hairline (HP:0000294)1.68306036
149Abnormality of the duodenum (HP:0002246)1.67531443
150Cerebral aneurysm (HP:0004944)1.66993053
151High pitched voice (HP:0001620)1.66729917
152Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66108529
153Conjunctival telangiectasia (HP:0000524)1.64456116
154Hypoglycemic seizures (HP:0002173)1.64062477
155Heterotopia (HP:0002282)1.63577890
156Decreased skull ossification (HP:0004331)1.62998385
157Skull defect (HP:0001362)1.62884734
158Chromosomal breakage induced by crosslinking agents (HP:0003221)1.62664546
159Xanthomatosis (HP:0000991)1.62481547
160Hepatoblastoma (HP:0002884)1.62211292
161Aplasia/hypoplasia of the humerus (HP:0006507)1.62191560
162Neoplasm of the small intestine (HP:0100833)1.61706669
163Myelodysplasia (HP:0002863)1.61200293
164Increased connective tissue (HP:0009025)1.61085217
165Neoplasm of the rectum (HP:0100743)1.60666800
166Meckel diverticulum (HP:0002245)1.60606214
167Abnormality of lateral ventricle (HP:0030047)1.59511027
168Pelvic girdle muscle weakness (HP:0003749)1.58932262
169Ectopic kidney (HP:0000086)1.58273619

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.22722042
2CDK123.19973687
3CDC73.05243837
4NEK23.00029261
5LATS12.99607351
6ERBB32.90361281
7BUB12.33882722
8PKN22.32790573
9NEK12.21145817
10BRSK22.19782667
11TTK2.08095067
12TAF12.05376973
13STK31.96455370
14MST41.87364935
15EEF2K1.81538765
16PBK1.80393440
17EPHA21.74446780
18ACVR1B1.73267996
19YES11.69022404
20CDK41.68183952
21STK101.63600086
22RPS6KA41.62103846
23CDK61.61672800
24MAP3K101.57456804
25EIF2AK11.52630502
26TRIB31.51793430
27PLK11.48775590
28CLK11.46248125
29TSSK61.45754220
30SRPK11.45476720
31RPS6KB21.45080512
32IRAK21.43213576
33AURKB1.41335263
34TRIM281.40899908
35PLK31.34656790
36NLK1.33714368
37DYRK31.32775099
38MAP3K81.29171859
39BCR1.26141488
40TTN1.25565939
41STK38L1.24621000
42MAP3K141.22885200
43LATS21.22795695
44ATR1.22586932
45CDK71.22169876
46FLT31.21987043
47STK41.21661226
48TEC1.20907201
49CHEK11.17926432
50CHEK21.17892163
51BMPR21.17477638
52CAMK1D1.16430862
53MAP3K41.13313498
54IRAK11.11166114
55MKNK11.09688291
56MTOR1.08568131
57PLK41.05652646
58MKNK21.01931254
59ALK1.01033054
60FGFR41.00475093
61SIK31.00205519
62MAP2K30.99176181
63MELK0.97931609
64MAP3K30.97491132
65SIK10.95655455
66PDK30.95538084
67PDK40.95538084
68TGFBR10.92688231
69SCYL20.90611791
70MAP3K60.90012571
71ATM0.89436511
72PIM10.88264728
73PRPF4B0.84502587
74PDGFRA0.84352313
75AKT30.84134983
76BRSK10.84091840
77RIPK10.83058703
78NEK60.82830223
79NEK90.82289780
80BRD40.81137609
81PAK40.81001176
82FGFR10.79673072
83TESK20.79607348
84LRRK20.79204635
85FGFR30.77929037
86CDK20.77745086
87PTK60.74887506
88CDK30.74317421
89ZAK0.74218080
90PLK20.73465576
91PASK0.73319882
92RPS6KB10.71632074
93MAP3K20.71091763
94FRK0.70605383
95RAF10.69720193
96KSR10.67962584
97EIF2AK30.66967206
98PDK20.66296938
99PIK3CG0.65920838
100MARK30.62389446
101NME20.61323886
102PAK20.60314988
103BTK0.59206526
104OBSCN0.58994929
105BCKDK0.57920191
106NUAK10.57101597
107WNK10.57089288
108CDK10.55721872
109MAP4K10.53418032
110EIF2AK20.51828974
111DDR20.51330053
112CSNK1G10.50226101
113MAPK110.49399874
114MAP3K50.49294478
115TYK20.48761168
116CAMK1G0.48704908
117KDR0.48415618
118AURKA0.48411226
119FGR0.47907087
120PDGFRB0.47870006
121EPHA30.46973154
122JAK10.46820742
123FGFR20.46522886
124JAK30.45807652
125CHUK0.44762346
126CDK90.43975507
127ERBB40.42740824
128EGFR0.42728970
129CAMKK20.39637496
130CSNK1D0.39270537
131ERN10.38386303
132AKT20.38145472
133CSNK2A20.37647543
134PNCK0.35515508
135KSR20.34898775
136STK240.34609098
137HCK0.34603913
138TAOK10.34022789
139MET0.33937616
140SGK20.33552230
141TRPM70.32440098
142DMPK0.32432243
143MAP2K70.30933129
144CSK0.30278337

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88890537
2RNA transport_Homo sapiens_hsa030132.65465585
3DNA replication_Homo sapiens_hsa030302.63046219
4One carbon pool by folate_Homo sapiens_hsa006702.46584012
5Cell cycle_Homo sapiens_hsa041102.40250738
6Mismatch repair_Homo sapiens_hsa034302.40119923
7Nitrogen metabolism_Homo sapiens_hsa009102.08439768
8Spliceosome_Homo sapiens_hsa030401.93488495
9Vitamin B6 metabolism_Homo sapiens_hsa007501.85371869
10Selenocompound metabolism_Homo sapiens_hsa004501.75062554
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74831316
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70535567
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66306375
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.62719190
15p53 signaling pathway_Homo sapiens_hsa041151.57869341
16Pancreatic cancer_Homo sapiens_hsa052121.56644791
17Nucleotide excision repair_Homo sapiens_hsa034201.50621570
18Biosynthesis of amino acids_Homo sapiens_hsa012301.48891796
19Base excision repair_Homo sapiens_hsa034101.47306199
20RNA polymerase_Homo sapiens_hsa030201.44691019
21mRNA surveillance pathway_Homo sapiens_hsa030151.43394703
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.42710096
23Non-small cell lung cancer_Homo sapiens_hsa052231.41816278
24Homologous recombination_Homo sapiens_hsa034401.40099973
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39354761
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33815924
27Lysine degradation_Homo sapiens_hsa003101.32721376
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.32682011
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.27503656
30Fanconi anemia pathway_Homo sapiens_hsa034601.26205556
31Pentose phosphate pathway_Homo sapiens_hsa000301.24665780
32Arginine biosynthesis_Homo sapiens_hsa002201.23671263
33Dorso-ventral axis formation_Homo sapiens_hsa043201.21190792
34RNA degradation_Homo sapiens_hsa030181.17558023
35Carbon metabolism_Homo sapiens_hsa012001.16018202
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.14449011
37Non-homologous end-joining_Homo sapiens_hsa034501.14268332
38Renal cell carcinoma_Homo sapiens_hsa052111.14224615
39Endometrial cancer_Homo sapiens_hsa052131.13101857
40Small cell lung cancer_Homo sapiens_hsa052221.11179333
41Fatty acid degradation_Homo sapiens_hsa000711.09847965
42MicroRNAs in cancer_Homo sapiens_hsa052061.09592910
43Circadian rhythm_Homo sapiens_hsa047101.09317878
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07445694
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07175636
46Measles_Homo sapiens_hsa051621.06120427
47Basal transcription factors_Homo sapiens_hsa030221.05677572
48Pyrimidine metabolism_Homo sapiens_hsa002401.05076957
49Systemic lupus erythematosus_Homo sapiens_hsa053221.03843465
50Viral carcinogenesis_Homo sapiens_hsa052031.03373857
51Inositol phosphate metabolism_Homo sapiens_hsa005621.02479558
52Folate biosynthesis_Homo sapiens_hsa007901.00326046
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98290028
54Adherens junction_Homo sapiens_hsa045200.96417954
55Complement and coagulation cascades_Homo sapiens_hsa046100.95188043
56Protein export_Homo sapiens_hsa030600.94992534
57Antigen processing and presentation_Homo sapiens_hsa046120.92130804
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90341241
59Acute myeloid leukemia_Homo sapiens_hsa052210.89222384
60Herpes simplex infection_Homo sapiens_hsa051680.89200997
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88645913
62B cell receptor signaling pathway_Homo sapiens_hsa046620.88483951
63Prolactin signaling pathway_Homo sapiens_hsa049170.88426772
64T cell receptor signaling pathway_Homo sapiens_hsa046600.87533531
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85944490
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85886280
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84907433
68Epstein-Barr virus infection_Homo sapiens_hsa051690.84169215
69Glioma_Homo sapiens_hsa052140.83372707
70Shigellosis_Homo sapiens_hsa051310.82700181
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.82581060
72TGF-beta signaling pathway_Homo sapiens_hsa043500.82431281
73mTOR signaling pathway_Homo sapiens_hsa041500.81477172
74Tryptophan metabolism_Homo sapiens_hsa003800.80808479
75Platelet activation_Homo sapiens_hsa046110.80324177
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78433922
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77417879
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.75515342
79HTLV-I infection_Homo sapiens_hsa051660.74412308
80Melanoma_Homo sapiens_hsa052180.74324426
81Thyroid cancer_Homo sapiens_hsa052160.72809230
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72805131
83Regulation of autophagy_Homo sapiens_hsa041400.72185568
84Caffeine metabolism_Homo sapiens_hsa002320.69503302
85Chronic myeloid leukemia_Homo sapiens_hsa052200.69006254
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68877671
87Insulin signaling pathway_Homo sapiens_hsa049100.68644948
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68587677
89Propanoate metabolism_Homo sapiens_hsa006400.68561065
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67887711
91PPAR signaling pathway_Homo sapiens_hsa033200.63669580
92Hippo signaling pathway_Homo sapiens_hsa043900.63323850
93Fatty acid metabolism_Homo sapiens_hsa012120.63315701
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.62257084
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61211153
96Legionellosis_Homo sapiens_hsa051340.60585442
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59444297
98Pathways in cancer_Homo sapiens_hsa052000.57322348
99Prostate cancer_Homo sapiens_hsa052150.55415992
100Proteasome_Homo sapiens_hsa030500.55053086
101Staphylococcus aureus infection_Homo sapiens_hsa051500.54962714
102Proteoglycans in cancer_Homo sapiens_hsa052050.54443231
103ErbB signaling pathway_Homo sapiens_hsa040120.53815846
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.53660506
105Viral myocarditis_Homo sapiens_hsa054160.53635087
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52269282
107Purine metabolism_Homo sapiens_hsa002300.52241373
108Oocyte meiosis_Homo sapiens_hsa041140.52172326
109Apoptosis_Homo sapiens_hsa042100.51362909
110Insulin resistance_Homo sapiens_hsa049310.50902871
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.50760981
112Vitamin digestion and absorption_Homo sapiens_hsa049770.50308798
113Alcoholism_Homo sapiens_hsa050340.50176907
114Wnt signaling pathway_Homo sapiens_hsa043100.48854769
115Pyruvate metabolism_Homo sapiens_hsa006200.48823588
116Retinol metabolism_Homo sapiens_hsa008300.48358215
117FoxO signaling pathway_Homo sapiens_hsa040680.48268640
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47928828
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47904964
120AMPK signaling pathway_Homo sapiens_hsa041520.47337937
121Notch signaling pathway_Homo sapiens_hsa043300.47337223
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46853191
123Sulfur relay system_Homo sapiens_hsa041220.46651937
124Starch and sucrose metabolism_Homo sapiens_hsa005000.46572726
125Choline metabolism in cancer_Homo sapiens_hsa052310.46435554
126Bladder cancer_Homo sapiens_hsa052190.45510424
127Influenza A_Homo sapiens_hsa051640.45330243
128Chemical carcinogenesis_Homo sapiens_hsa052040.42665331
129Basal cell carcinoma_Homo sapiens_hsa052170.42428832
130Colorectal cancer_Homo sapiens_hsa052100.42418596
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42415134
132Ribosome_Homo sapiens_hsa030100.42150396
133Hepatitis B_Homo sapiens_hsa051610.41421057
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40745580
135ECM-receptor interaction_Homo sapiens_hsa045120.40574873
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40414938
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.40409108
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.40317886
139Focal adhesion_Homo sapiens_hsa045100.39783281
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39685687
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39229719
142beta-Alanine metabolism_Homo sapiens_hsa004100.39024011
143Osteoclast differentiation_Homo sapiens_hsa043800.36045675
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.35581275
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34226663

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