

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | gamma-aminobutyric acid transport (GO:0015812) | 5.81002320 |
| 2 | neuron cell-cell adhesion (GO:0007158) | 5.50406815 |
| 3 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 5.44076664 |
| 4 | vocalization behavior (GO:0071625) | 5.35554565 |
| 5 | protein localization to synapse (GO:0035418) | 5.32043774 |
| 6 | glutamate receptor signaling pathway (GO:0007215) | 5.27203085 |
| 7 | synaptic vesicle maturation (GO:0016188) | 5.16782166 |
| 8 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.09996911 |
| 9 | presynaptic membrane assembly (GO:0097105) | 5.06926920 |
| 10 | postsynaptic membrane organization (GO:0001941) | 4.67153803 |
| 11 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.65235040 |
| 12 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.60720064 |
| 13 | neuron recognition (GO:0008038) | 4.55977225 |
| 14 | presynaptic membrane organization (GO:0097090) | 4.54562887 |
| 15 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.53640240 |
| 16 | neuronal action potential propagation (GO:0019227) | 4.37630176 |
| 17 | neuron-neuron synaptic transmission (GO:0007270) | 4.27356785 |
| 18 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.24119460 |
| 19 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.23797634 |
| 20 | response to histamine (GO:0034776) | 4.20049825 |
| 21 | synaptic transmission, glutamatergic (GO:0035249) | 4.19223256 |
| 22 | * gamma-aminobutyric acid signaling pathway (GO:0007214) | 4.15608330 |
| 23 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 4.13027657 |
| 24 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 4.12630191 |
| 25 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.09840407 |
| 26 | synaptic vesicle exocytosis (GO:0016079) | 3.98243084 |
| 27 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.97957495 |
| 28 | regulation of glutamate secretion (GO:0014048) | 3.87248156 |
| 29 | behavioral fear response (GO:0001662) | 3.86624737 |
| 30 | behavioral defense response (GO:0002209) | 3.86624737 |
| 31 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.84538313 |
| 32 | auditory behavior (GO:0031223) | 3.81137188 |
| 33 | regulation of postsynaptic membrane potential (GO:0060078) | 3.81136143 |
| 34 | membrane depolarization during action potential (GO:0086010) | 3.79561883 |
| 35 | fear response (GO:0042596) | 3.76602008 |
| 36 | exploration behavior (GO:0035640) | 3.74830532 |
| 37 | axonal fasciculation (GO:0007413) | 3.73482760 |
| 38 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.72702764 |
| 39 | nucleobase catabolic process (GO:0046113) | 3.69208186 |
| 40 | positive regulation of synapse assembly (GO:0051965) | 3.67184519 |
| 41 | righting reflex (GO:0060013) | 3.65747104 |
| 42 | transmission of nerve impulse (GO:0019226) | 3.65109011 |
| 43 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.62679796 |
| 44 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.60047824 |
| 45 | regulation of synapse structural plasticity (GO:0051823) | 3.57109219 |
| 46 | long-term synaptic potentiation (GO:0060291) | 3.55893130 |
| 47 | serotonin metabolic process (GO:0042428) | 3.55339548 |
| 48 | long-term memory (GO:0007616) | 3.52711379 |
| 49 | positive regulation of inositol phosphate biosynthetic process (GO:0060732) | 3.50518166 |
| 50 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.47209470 |
| 51 | positive regulation of dendritic spine development (GO:0060999) | 3.44530567 |
| 52 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.43629981 |
| 53 | startle response (GO:0001964) | 3.43547138 |
| 54 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.42530200 |
| 55 | locomotory exploration behavior (GO:0035641) | 3.38171331 |
| 56 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.37264454 |
| 57 | serotonin receptor signaling pathway (GO:0007210) | 3.35762724 |
| 58 | dendritic spine morphogenesis (GO:0060997) | 3.35313514 |
| 59 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.34035363 |
| 60 | synaptic vesicle endocytosis (GO:0048488) | 3.33396195 |
| 61 | behavioral response to nicotine (GO:0035095) | 3.31250041 |
| 62 | primary amino compound metabolic process (GO:1901160) | 3.30084935 |
| 63 | regulation of vesicle fusion (GO:0031338) | 3.29680818 |
| 64 | regulation of inositol phosphate biosynthetic process (GO:0010919) | 3.29680522 |
| 65 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.28736042 |
| 66 | neuron remodeling (GO:0016322) | 3.26073279 |
| 67 | positive regulation of membrane potential (GO:0045838) | 3.23753583 |
| 68 | regulation of dendritic spine development (GO:0060998) | 3.23375727 |
| 69 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.23364847 |
| 70 | regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315) | 3.22134887 |
| 71 | behavioral response to cocaine (GO:0048148) | 3.21531259 |
| 72 | * neurotransmitter transport (GO:0006836) | 3.21321577 |
| 73 | response to auditory stimulus (GO:0010996) | 3.21180303 |
| 74 | * regulation of neurotransmitter levels (GO:0001505) | 3.20564660 |
| 75 | regulation of synaptic vesicle transport (GO:1902803) | 3.20009495 |
| 76 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.19879541 |
| 77 | regulation of axon regeneration (GO:0048679) | 3.19757517 |
| 78 | regulation of neuron projection regeneration (GO:0070570) | 3.19757517 |
| 79 | detection of calcium ion (GO:0005513) | 3.19525298 |
| 80 | neuronal ion channel clustering (GO:0045161) | 3.18789816 |
| 81 | regulation of synaptic plasticity (GO:0048167) | 3.18352206 |
| 82 | glutamate secretion (GO:0014047) | 3.17547224 |
| 83 | female mating behavior (GO:0060180) | 3.17212323 |
| 84 | negative regulation of neurotransmitter transport (GO:0051589) | 3.16378323 |
| 85 | neuronal action potential (GO:0019228) | 3.13235514 |
| 86 | establishment of mitochondrion localization (GO:0051654) | 3.10734277 |
| 87 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.10411142 |
| 88 | regulation of protein kinase A signaling (GO:0010738) | 3.10017555 |
| 89 | cochlea development (GO:0090102) | 3.09182734 |
| 90 | regulation of female receptivity (GO:0045924) | 3.08765466 |
| 91 | membrane depolarization (GO:0051899) | 3.08398855 |
| 92 | regulation of synapse assembly (GO:0051963) | 3.05880942 |
| 93 | learning (GO:0007612) | 3.05742657 |
| 94 | positive regulation of response to oxidative stress (GO:1902884) | 3.04821631 |
| 95 | positive regulation of cellular response to oxidative stress (GO:1900409) | 3.04821631 |
| 96 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.03445128 |
| 97 | synaptic transmission, dopaminergic (GO:0001963) | 3.02064138 |
| 98 | * synaptic transmission (GO:0007268) | 3.01300491 |
| 99 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.00471668 |
| 100 | calcium-mediated signaling using intracellular calcium source (GO:0035584) | 2.99450813 |
| 101 | mechanosensory behavior (GO:0007638) | 2.98957002 |
| 102 | dendritic spine organization (GO:0097061) | 2.98850401 |
| 103 | synapse assembly (GO:0007416) | 2.98558550 |
| 104 | protein localization to cilium (GO:0061512) | 2.97852600 |
| 105 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.97669834 |
| 106 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.96393167 |
| 107 | positive regulation of neurotransmitter transport (GO:0051590) | 2.95870485 |
| 108 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.94478065 |
| 109 | positive regulation of synapse maturation (GO:0090129) | 2.94110774 |
| 110 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.93381467 |
| 111 | positive regulation of phosphoprotein phosphatase activity (GO:0032516) | 2.93233841 |
| 112 | glycosphingolipid biosynthetic process (GO:0006688) | 2.92144260 |
| 113 | neuromuscular synaptic transmission (GO:0007274) | 2.91988775 |
| 114 | regulation of dopamine metabolic process (GO:0042053) | 2.88786128 |
| 115 | regulation of catecholamine metabolic process (GO:0042069) | 2.88786128 |
| 116 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 2.88769194 |
| 117 | dendrite morphogenesis (GO:0048813) | 2.88639412 |
| 118 | neurotransmitter secretion (GO:0007269) | 2.88591276 |
| 119 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.86259416 |
| 120 | cell migration in hindbrain (GO:0021535) | 2.85497696 |
| 121 | long term synaptic depression (GO:0060292) | 2.84781478 |
| 122 | regulation of neurotransmitter secretion (GO:0046928) | 2.84201935 |
| 123 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.83642542 |
| 124 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.83640973 |
| 125 | behavioral response to ethanol (GO:0048149) | 2.83510972 |
| 126 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.81491488 |
| 127 | adult walking behavior (GO:0007628) | 2.80772796 |
| 128 | acidic amino acid transport (GO:0015800) | 2.79162555 |
| 129 | innervation (GO:0060384) | 2.78185530 |
| 130 | proline transport (GO:0015824) | 2.77501943 |
| 131 | regulation of synapse maturation (GO:0090128) | 2.77456341 |
| 132 | dendrite development (GO:0016358) | 2.77073048 |
| 133 | regulation of synapse organization (GO:0050807) | 2.76875650 |
| 134 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.76752178 |
| 135 | C4-dicarboxylate transport (GO:0015740) | 2.75633644 |
| 136 | regulation of respiratory system process (GO:0044065) | 2.75592806 |
| 137 | adult behavior (GO:0030534) | 2.75317181 |
| 138 | synapse organization (GO:0050808) | 2.74699460 |
| 139 | regulation of neurotransmitter transport (GO:0051588) | 2.73692837 |
| 140 | negative regulation of cAMP biosynthetic process (GO:0030818) | 2.70213527 |
| 141 | cellular potassium ion homeostasis (GO:0030007) | 2.69870266 |
| 142 | regulation of sarcomere organization (GO:0060297) | 2.69258300 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.19186154 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 4.37746493 |
| 3 | * JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.12169220 |
| 4 | * SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.04854623 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.94690540 |
| 6 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.78901218 |
| 7 | * SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.70793272 |
| 8 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.55199457 |
| 9 | * SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.54091303 |
| 10 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.50461075 |
| 11 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.49671032 |
| 12 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.49671032 |
| 13 | * ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.47761876 |
| 14 | * JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.45311040 |
| 15 | * SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.44759268 |
| 16 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.33223632 |
| 17 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.27782733 |
| 18 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.23732403 |
| 19 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.23543859 |
| 20 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.22059537 |
| 21 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.16390510 |
| 22 | VDR_22108803_ChIP-Seq_LS180_Human | 2.03842303 |
| 23 | P300_19829295_ChIP-Seq_ESCs_Human | 2.02328846 |
| 24 | * BMI1_23680149_ChIP-Seq_NPCS_Mouse | 2.01461490 |
| 25 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.99473943 |
| 26 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.99338222 |
| 27 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.98819383 |
| 28 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.97910315 |
| 29 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.96963797 |
| 30 | * POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.96961226 |
| 31 | FUS_26573619_Chip-Seq_HEK293_Human | 1.92863361 |
| 32 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.91460682 |
| 33 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 1.85176900 |
| 34 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.78953130 |
| 35 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.76410900 |
| 36 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.69586285 |
| 37 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.66038642 |
| 38 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.65943068 |
| 39 | * REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.64070202 |
| 40 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.58532714 |
| 41 | * TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.56738040 |
| 42 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.56619931 |
| 43 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.55074077 |
| 44 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.54751655 |
| 45 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.54408859 |
| 46 | * SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.53954621 |
| 47 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.53013170 |
| 48 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.50571478 |
| 49 | * RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.50333773 |
| 50 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.50116331 |
| 51 | AR_25329375_ChIP-Seq_VCAP_Human | 1.46269202 |
| 52 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.45607534 |
| 53 | * UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.44617071 |
| 54 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.41111846 |
| 55 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.40754985 |
| 56 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.36502433 |
| 57 | * SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.36062203 |
| 58 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.34207616 |
| 59 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.32359293 |
| 60 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.31721163 |
| 61 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.31347137 |
| 62 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.30316084 |
| 63 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.28852947 |
| 64 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.26860258 |
| 65 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.25362625 |
| 66 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.25226402 |
| 67 | TP53_16413492_ChIP-PET_HCT116_Human | 1.24624305 |
| 68 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.24037847 |
| 69 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.23790714 |
| 70 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.21205893 |
| 71 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.20889412 |
| 72 | * IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.19816398 |
| 73 | * CBP_20019798_ChIP-Seq_JUKART_Human | 1.19816398 |
| 74 | * EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.19512783 |
| 75 | JUN_21703547_ChIP-Seq_K562_Human | 1.18483258 |
| 76 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.18209491 |
| 77 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.16440499 |
| 78 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.15812753 |
| 79 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.14275092 |
| 80 | EWS_26573619_Chip-Seq_HEK293_Human | 1.13423034 |
| 81 | AR_19668381_ChIP-Seq_PC3_Human | 1.13260540 |
| 82 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.12978440 |
| 83 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.12013862 |
| 84 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.11720658 |
| 85 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.11612851 |
| 86 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.11462388 |
| 87 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.11462388 |
| 88 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.11414356 |
| 89 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.08508497 |
| 90 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.08440389 |
| 91 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.07567433 |
| 92 | KDM2B_26808549_Chip-Seq_REH_Human | 1.07560277 |
| 93 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.06609772 |
| 94 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.05388872 |
| 95 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.05235342 |
| 96 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.03536151 |
| 97 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.03502958 |
| 98 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.03187446 |
| 99 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.02491599 |
| 100 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.02178733 |
| 101 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.02131358 |
| 102 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.01923573 |
| 103 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.01414419 |
| 104 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.00932352 |
| 105 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.00719371 |
| 106 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.00467095 |
| 107 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.00373829 |
| 108 | * KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.99837362 |
| 109 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.99757432 |
| 110 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.99471965 |
| 111 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 0.99426769 |
| 112 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.98099121 |
| 113 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.96901517 |
| 114 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.95651865 |
| 115 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.95346504 |
| 116 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.95159309 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 6.38282381 |
| 2 | MP0004859_abnormal_synaptic_plasticity | 4.88426133 |
| 3 | * MP0003635_abnormal_synaptic_transmissio | 3.71034062 |
| 4 | * MP0009745_abnormal_behavioral_response | 3.39581663 |
| 5 | MP0001968_abnormal_touch/_nociception | 3.26754571 |
| 6 | * MP0002063_abnormal_learning/memory/cond | 3.07094899 |
| 7 | MP0002736_abnormal_nociception_after | 3.01620756 |
| 8 | MP0004270_analgesia | 2.94671239 |
| 9 | MP0002064_seizures | 2.94338973 |
| 10 | MP0002572_abnormal_emotion/affect_behav | 2.80354316 |
| 11 | MP0001501_abnormal_sleep_pattern | 2.75801129 |
| 12 | MP0002735_abnormal_chemical_nociception | 2.66705414 |
| 13 | MP0002272_abnormal_nervous_system | 2.65079353 |
| 14 | MP0001188_hyperpigmentation | 2.64123220 |
| 15 | MP0006276_abnormal_autonomic_nervous | 2.59141437 |
| 16 | MP0001440_abnormal_grooming_behavior | 2.57622411 |
| 17 | MP0009046_muscle_twitch | 2.56678752 |
| 18 | MP0001486_abnormal_startle_reflex | 2.41459987 |
| 19 | MP0000569_abnormal_digit_pigmentation | 2.34524603 |
| 20 | MP0001529_abnormal_vocalization | 2.20661454 |
| 21 | MP0002734_abnormal_mechanical_nocicepti | 2.14310588 |
| 22 | MP0002067_abnormal_sensory_capabilities | 2.11285470 |
| 23 | MP0005423_abnormal_somatic_nervous | 1.99701048 |
| 24 | MP0005409_darkened_coat_color | 1.92406548 |
| 25 | MP0000778_abnormal_nervous_system | 1.91569987 |
| 26 | MP0002184_abnormal_innervation | 1.86823070 |
| 27 | MP0001970_abnormal_pain_threshold | 1.81400075 |
| 28 | MP0002733_abnormal_thermal_nociception | 1.80950806 |
| 29 | MP0009379_abnormal_foot_pigmentation | 1.79089513 |
| 30 | MP0002837_dystrophic_cardiac_calcinosis | 1.76066643 |
| 31 | MP0006292_abnormal_olfactory_placode | 1.74529214 |
| 32 | MP0003329_amyloid_beta_deposits | 1.74003722 |
| 33 | MP0002557_abnormal_social/conspecific_i | 1.72143419 |
| 34 | MP0005645_abnormal_hypothalamus_physiol | 1.69686787 |
| 35 | MP0001986_abnormal_taste_sensitivity | 1.68274476 |
| 36 | MP0001905_abnormal_dopamine_level | 1.60354996 |
| 37 | MP0002822_catalepsy | 1.59965020 |
| 38 | MP0004924_abnormal_behavior | 1.54760996 |
| 39 | MP0005386_behavior/neurological_phenoty | 1.54760996 |
| 40 | MP0002876_abnormal_thyroid_physiology | 1.53999310 |
| 41 | MP0004147_increased_porphyrin_level | 1.53090293 |
| 42 | MP0001984_abnormal_olfaction | 1.47526539 |
| 43 | MP0004142_abnormal_muscle_tone | 1.45397525 |
| 44 | MP0005646_abnormal_pituitary_gland | 1.44007721 |
| 45 | MP0003136_yellow_coat_color | 1.40433509 |
| 46 | MP0003879_abnormal_hair_cell | 1.35127014 |
| 47 | MP0003787_abnormal_imprinting | 1.33616600 |
| 48 | MP0009780_abnormal_chondrocyte_physiolo | 1.31549339 |
| 49 | MP0002102_abnormal_ear_morphology | 1.29155527 |
| 50 | MP0002066_abnormal_motor_capabilities/c | 1.26782985 |
| 51 | MP0004145_abnormal_muscle_electrophysio | 1.26042282 |
| 52 | MP0004742_abnormal_vestibular_system | 1.24566581 |
| 53 | MP0002882_abnormal_neuron_morphology | 1.24473778 |
| 54 | MP0000955_abnormal_spinal_cord | 1.23212044 |
| 55 | MP0001502_abnormal_circadian_rhythm | 1.20694388 |
| 56 | MP0004811_abnormal_neuron_physiology | 1.13898667 |
| 57 | MP0005551_abnormal_eye_electrophysiolog | 1.12843874 |
| 58 | MP0008569_lethality_at_weaning | 1.12802601 |
| 59 | MP0001963_abnormal_hearing_physiology | 1.12168691 |
| 60 | MP0003122_maternal_imprinting | 1.09475715 |
| 61 | MP0004484_altered_response_of | 1.09033425 |
| 62 | MP0004043_abnormal_pH_regulation | 1.08148963 |
| 63 | MP0000026_abnormal_inner_ear | 0.99824407 |
| 64 | MP0008877_abnormal_DNA_methylation | 0.96846418 |
| 65 | MP0002234_abnormal_pharynx_morphology | 0.95175903 |
| 66 | MP0000631_abnormal_neuroendocrine_gland | 0.95175642 |
| 67 | MP0004858_abnormal_nervous_system | 0.94437326 |
| 68 | MP0001664_abnormal_digestion | 0.93053653 |
| 69 | MP0002152_abnormal_brain_morphology | 0.93015751 |
| 70 | MP0003938_abnormal_ear_development | 0.92411977 |
| 71 | MP0003633_abnormal_nervous_system | 0.92409509 |
| 72 | MP0010386_abnormal_urinary_bladder | 0.91661976 |
| 73 | MP0004885_abnormal_endolymph | 0.90599952 |
| 74 | MP0002229_neurodegeneration | 0.90507706 |
| 75 | MP0005379_endocrine/exocrine_gland_phen | 0.90349174 |
| 76 | MP0002752_abnormal_somatic_nervous | 0.89994639 |
| 77 | MP0001177_atelectasis | 0.89811970 |
| 78 | MP0000566_synostosis | 0.85612071 |
| 79 | MP0005535_abnormal_body_temperature | 0.85333395 |
| 80 | MP0003119_abnormal_digestive_system | 0.84702963 |
| 81 | MP0000015_abnormal_ear_pigmentation | 0.84614981 |
| 82 | MP0005171_absent_coat_pigmentation | 0.83513043 |
| 83 | MP0002069_abnormal_eating/drinking_beha | 0.82363162 |
| 84 | MP0003631_nervous_system_phenotype | 0.82287581 |
| 85 | MP0004133_heterotaxia | 0.82225461 |
| 86 | MP0003137_abnormal_impulse_conducting | 0.79863796 |
| 87 | MP0000751_myopathy | 0.79759354 |
| 88 | MP0004085_abnormal_heartbeat | 0.79263912 |
| 89 | MP0005377_hearing/vestibular/ear_phenot | 0.78417931 |
| 90 | MP0003878_abnormal_ear_physiology | 0.78417931 |
| 91 | MP0003195_calcinosis | 0.78002729 |
| 92 | MP0001485_abnormal_pinna_reflex | 0.77845442 |
| 93 | MP0002909_abnormal_adrenal_gland | 0.77473679 |
| 94 | MP0008874_decreased_physiological_sensi | 0.76063594 |
| 95 | MP0006072_abnormal_retinal_apoptosis | 0.75585965 |
| 96 | MP0008872_abnormal_physiological_respon | 0.75283099 |
| 97 | MP0005499_abnormal_olfactory_system | 0.75252845 |
| 98 | MP0005394_taste/olfaction_phenotype | 0.75252845 |
| 99 | MP0000604_amyloidosis | 0.74545109 |
| 100 | MP0002751_abnormal_autonomic_nervous | 0.68409846 |
| 101 | MP0004215_abnormal_myocardial_fiber | 0.68196959 |
| 102 | MP0002653_abnormal_ependyma_morphology | 0.66588107 |
| 103 | MP0005595_abnormal_vascular_smooth | 0.63833806 |
| 104 | MP0002638_abnormal_pupillary_reflex | 0.63704329 |
| 105 | MP0003121_genomic_imprinting | 0.63026873 |
| 106 | MP0002090_abnormal_vision | 0.62721135 |
| 107 | MP0002163_abnormal_gland_morphology | 0.61589198 |
| 108 | MP0003634_abnormal_glial_cell | 0.61135710 |
| 109 | MP0003861_abnormal_nervous_system | 0.59878030 |
| 110 | MP0005195_abnormal_posterior_eye | 0.58507900 |
| 111 | MP0003690_abnormal_glial_cell | 0.57820094 |
| 112 | MP0001765_abnormal_ion_homeostasis | 0.57571943 |
| 113 | MP0004510_myositis | 0.56742037 |
| 114 | MP0005174_abnormal_tail_pigmentation | 0.56724333 |
| 115 | MP0000681_abnormal_thyroid_gland | 0.53158312 |
| 116 | MP0003011_delayed_dark_adaptation | 0.53097513 |
| 117 | MP0005187_abnormal_penis_morphology | 0.53079321 |
| 118 | MP0003632_abnormal_nervous_system | 0.52575232 |
| 119 | MP0000049_abnormal_middle_ear | 0.52112595 |
| 120 | MP0000920_abnormal_myelination | 0.51654562 |
| 121 | MP0005167_abnormal_blood-brain_barrier | 0.51561454 |
| 122 | MP0005410_abnormal_fertilization | 0.49985933 |
| 123 | MP0001943_abnormal_respiration | 0.49032772 |
| 124 | MP0005253_abnormal_eye_physiology | 0.45509531 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.87793412 |
| 2 | Atonic seizures (HP:0010819) | 5.24909616 |
| 3 | Hyperventilation (HP:0002883) | 5.22559301 |
| 4 | Focal seizures (HP:0007359) | 5.08089327 |
| 5 | Febrile seizures (HP:0002373) | 4.69113944 |
| 6 | Epileptic encephalopathy (HP:0200134) | 4.69100251 |
| 7 | Visual hallucinations (HP:0002367) | 4.47473197 |
| 8 | Absence seizures (HP:0002121) | 4.42711058 |
| 9 | Dialeptic seizures (HP:0011146) | 4.18132079 |
| 10 | Myokymia (HP:0002411) | 3.93845416 |
| 11 | Limb dystonia (HP:0002451) | 3.90173002 |
| 12 | Broad-based gait (HP:0002136) | 3.76949695 |
| 13 | Cerebral inclusion bodies (HP:0100314) | 3.69100135 |
| 14 | Generalized tonic-clonic seizures (HP:0002069) | 3.64663403 |
| 15 | Genetic anticipation (HP:0003743) | 3.59686240 |
| 16 | Drooling (HP:0002307) | 3.37068285 |
| 17 | Excessive salivation (HP:0003781) | 3.37068285 |
| 18 | Amblyopia (HP:0000646) | 3.27827928 |
| 19 | Urinary bladder sphincter dysfunction (HP:0002839) | 3.19609307 |
| 20 | Ankle clonus (HP:0011448) | 3.19021819 |
| 21 | Absent/shortened dynein arms (HP:0200106) | 3.18423104 |
| 22 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.18423104 |
| 23 | Progressive cerebellar ataxia (HP:0002073) | 3.17380000 |
| 24 | Absent speech (HP:0001344) | 3.10205510 |
| 25 | Neurofibrillary tangles (HP:0002185) | 3.06311745 |
| 26 | Acute necrotizing encephalopathy (HP:0006965) | 3.06260776 |
| 27 | Abnormal ciliary motility (HP:0012262) | 2.99709893 |
| 28 | Urinary urgency (HP:0000012) | 2.94137447 |
| 29 | Abnormality of binocular vision (HP:0011514) | 2.86617998 |
| 30 | Diplopia (HP:0000651) | 2.86617998 |
| 31 | Spastic gait (HP:0002064) | 2.80242056 |
| 32 | Inability to walk (HP:0002540) | 2.79543142 |
| 33 | Supranuclear gaze palsy (HP:0000605) | 2.74978791 |
| 34 | Progressive macrocephaly (HP:0004481) | 2.74755473 |
| 35 | Delusions (HP:0000746) | 2.70380922 |
| 36 | Anxiety (HP:0000739) | 2.68936182 |
| 37 | Protruding tongue (HP:0010808) | 2.68604675 |
| 38 | Progressive inability to walk (HP:0002505) | 2.65310370 |
| 39 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.62198370 |
| 40 | Mutism (HP:0002300) | 2.60588323 |
| 41 | Truncal ataxia (HP:0002078) | 2.60163840 |
| 42 | Dysmetria (HP:0001310) | 2.58986359 |
| 43 | Hemiparesis (HP:0001269) | 2.58213672 |
| 44 | Pendular nystagmus (HP:0012043) | 2.57026567 |
| 45 | Fair hair (HP:0002286) | 2.56196722 |
| 46 | Gaze-evoked nystagmus (HP:0000640) | 2.55897249 |
| 47 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.55417305 |
| 48 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.55417305 |
| 49 | Poor eye contact (HP:0000817) | 2.52160785 |
| 50 | Epileptiform EEG discharges (HP:0011182) | 2.48375106 |
| 51 | Mitochondrial inheritance (HP:0001427) | 2.48294140 |
| 52 | Dysdiadochokinesis (HP:0002075) | 2.46609684 |
| 53 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.43411142 |
| 54 | Amyotrophic lateral sclerosis (HP:0007354) | 2.42551003 |
| 55 | Abnormality of salivation (HP:0100755) | 2.42418271 |
| 56 | Postural instability (HP:0002172) | 2.40306272 |
| 57 | Optic disc pallor (HP:0000543) | 2.37906595 |
| 58 | Spastic tetraplegia (HP:0002510) | 2.35963135 |
| 59 | Gait imbalance (HP:0002141) | 2.34276243 |
| 60 | Medial flaring of the eyebrow (HP:0010747) | 2.33685370 |
| 61 | Pachygyria (HP:0001302) | 2.32476453 |
| 62 | Lissencephaly (HP:0001339) | 2.32125757 |
| 63 | Type II lissencephaly (HP:0007260) | 2.28908713 |
| 64 | Congenital stationary night blindness (HP:0007642) | 2.24543892 |
| 65 | Retinal dysplasia (HP:0007973) | 2.24542296 |
| 66 | Lower limb muscle weakness (HP:0007340) | 2.23232207 |
| 67 | Acute encephalopathy (HP:0006846) | 2.19077540 |
| 68 | EEG with generalized epileptiform discharges (HP:0011198) | 2.16403229 |
| 69 | Generalized myoclonic seizures (HP:0002123) | 2.16228484 |
| 70 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.14957553 |
| 71 | Split foot (HP:0001839) | 2.13225490 |
| 72 | Akinesia (HP:0002304) | 2.12985813 |
| 73 | Esotropia (HP:0000565) | 2.12463718 |
| 74 | Testicular atrophy (HP:0000029) | 2.11607717 |
| 75 | Pancreatic cysts (HP:0001737) | 2.11520689 |
| 76 | Impaired social interactions (HP:0000735) | 2.11161129 |
| 77 | Abnormal social behavior (HP:0012433) | 2.11161129 |
| 78 | Intention tremor (HP:0002080) | 2.10973090 |
| 79 | Generalized hypopigmentation of hair (HP:0011358) | 2.10537215 |
| 80 | Congenital primary aphakia (HP:0007707) | 2.08685332 |
| 81 | Vaginal atresia (HP:0000148) | 2.08285440 |
| 82 | Poor suck (HP:0002033) | 2.07595068 |
| 83 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.07119650 |
| 84 | Hypoplasia of the brainstem (HP:0002365) | 2.07119650 |
| 85 | Action tremor (HP:0002345) | 2.06926948 |
| 86 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.06766760 |
| 87 | Abnormal eating behavior (HP:0100738) | 2.05263034 |
| 88 | Blue irides (HP:0000635) | 2.03917746 |
| 89 | Nephronophthisis (HP:0000090) | 2.03001546 |
| 90 | Psychosis (HP:0000709) | 2.02040775 |
| 91 | Polyphagia (HP:0002591) | 2.01697890 |
| 92 | Thickened helices (HP:0000391) | 2.00238335 |
| 93 | Specific learning disability (HP:0001328) | 2.00107297 |
| 94 | Termporal pattern (HP:0011008) | 1.99989076 |
| 95 | Insidious onset (HP:0003587) | 1.99989076 |
| 96 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.99470747 |
| 97 | Exotropia (HP:0000577) | 1.98880984 |
| 98 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.98444549 |
| 99 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.97840800 |
| 100 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.97840800 |
| 101 | True hermaphroditism (HP:0010459) | 1.97183185 |
| 102 | Hypothermia (HP:0002045) | 1.95973346 |
| 103 | Thyroid-stimulating hormone excess (HP:0002925) | 1.95415646 |
| 104 | Congenital malformation of the right heart (HP:0011723) | 1.95327738 |
| 105 | Double outlet right ventricle (HP:0001719) | 1.95327738 |
| 106 | Nephrogenic diabetes insipidus (HP:0009806) | 1.94376341 |
| 107 | Depression (HP:0000716) | 1.93852450 |
| 108 | Widely spaced teeth (HP:0000687) | 1.93029703 |
| 109 | Fetal akinesia sequence (HP:0001989) | 1.92942936 |
| 110 | Volvulus (HP:0002580) | 1.92865016 |
| 111 | Scanning speech (HP:0002168) | 1.91685272 |
| 112 | Clonus (HP:0002169) | 1.91155201 |
| 113 | Short tibia (HP:0005736) | 1.91098905 |
| 114 | Impaired vibratory sensation (HP:0002495) | 1.89868166 |
| 115 | Status epilepticus (HP:0002133) | 1.89027687 |
| 116 | Oligodactyly (hands) (HP:0001180) | 1.88784147 |
| 117 | Optic nerve hypoplasia (HP:0000609) | 1.88704354 |
| 118 | Hypoplasia of the corpus callosum (HP:0002079) | 1.88672542 |
| 119 | Hydroureter (HP:0000072) | 1.88567965 |
| 120 | Peripheral hypomyelination (HP:0007182) | 1.88384303 |
| 121 | Increased CSF lactate (HP:0002490) | 1.87859903 |
| 122 | Hypsarrhythmia (HP:0002521) | 1.87843599 |
| 123 | Gastroesophageal reflux (HP:0002020) | 1.87318779 |
| 124 | Hemiplegia (HP:0002301) | 1.87027760 |
| 125 | Pancreatic fibrosis (HP:0100732) | 1.86668621 |
| 126 | Abnormality of the corticospinal tract (HP:0002492) | 1.86053460 |
| 127 | Dysmetric saccades (HP:0000641) | 1.85714909 |
| 128 | X-linked dominant inheritance (HP:0001423) | 1.83923094 |
| 129 | Abnormality of macular pigmentation (HP:0008002) | 1.83003038 |
| 130 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.79966768 |
| 131 | Dyskinesia (HP:0100660) | 1.79855191 |
| 132 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.78554935 |
| 133 | Impaired smooth pursuit (HP:0007772) | 1.77537334 |
| 134 | Horizontal nystagmus (HP:0000666) | 1.77136700 |
| 135 | Abnormal hair whorl (HP:0010721) | 1.75562058 |
| 136 | Abnormality of the lower motor neuron (HP:0002366) | 1.75230182 |
| 137 | Intellectual disability, severe (HP:0010864) | 1.75181638 |
| 138 | Increased hepatocellular lipid droplets (HP:0006565) | 1.75048124 |
| 139 | Tubulointerstitial nephritis (HP:0001970) | 1.74626328 |
| 140 | Dysautonomia (HP:0002459) | 1.72137218 |
| 141 | Rhinitis (HP:0012384) | 1.70659703 |
| 142 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.70198164 |
| 143 | Genital tract atresia (HP:0001827) | 1.70181796 |
| 144 | Decreased circulating renin level (HP:0003351) | 1.68708357 |
| 145 | Clumsiness (HP:0002312) | 1.68383934 |
| 146 | Ulnar claw (HP:0001178) | 1.67795775 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 4.87131640 |
| 2 | CASK | 4.73492924 |
| 3 | NTRK3 | 4.56878956 |
| 4 | RIPK4 | 3.56312440 |
| 5 | MAP2K7 | 2.88741493 |
| 6 | PNCK | 2.88735195 |
| 7 | MAP3K12 | 2.81774398 |
| 8 | TNIK | 2.64655986 |
| 9 | MAP3K4 | 2.63506102 |
| 10 | MAP4K2 | 2.60883233 |
| 11 | WNK3 | 2.40163689 |
| 12 | PLK2 | 2.31800815 |
| 13 | FRK | 2.26815290 |
| 14 | MINK1 | 2.09878859 |
| 15 | MAP3K9 | 2.02088400 |
| 16 | BMPR2 | 1.85990228 |
| 17 | GRK5 | 1.84331858 |
| 18 | FGR | 1.84171970 |
| 19 | FES | 1.79746211 |
| 20 | PINK1 | 1.77607685 |
| 21 | MARK1 | 1.77537466 |
| 22 | MAP2K4 | 1.73142744 |
| 23 | NME1 | 1.72663636 |
| 24 | GRK7 | 1.55685538 |
| 25 | SIK2 | 1.54460438 |
| 26 | MAP3K13 | 1.47282184 |
| 27 | MUSK | 1.46155674 |
| 28 | ARAF | 1.45480537 |
| 29 | PTK2B | 1.44774107 |
| 30 | TRIM28 | 1.43728597 |
| 31 | NTRK2 | 1.40896158 |
| 32 | CAMK2A | 1.39122179 |
| 33 | TAOK3 | 1.33458655 |
| 34 | DAPK1 | 1.31705246 |
| 35 | CAMK2B | 1.30242603 |
| 36 | MAPK13 | 1.28454427 |
| 37 | DYRK2 | 1.27444369 |
| 38 | CDK19 | 1.17951557 |
| 39 | DAPK2 | 1.17935060 |
| 40 | KSR1 | 1.17442082 |
| 41 | GRK6 | 1.12201144 |
| 42 | CAMKK1 | 1.10999984 |
| 43 | CSNK1A1L | 1.10982854 |
| 44 | PRKCG | 1.10678937 |
| 45 | CDK5 | 1.10118774 |
| 46 | EPHA3 | 1.06901844 |
| 47 | CSNK1G3 | 1.06366985 |
| 48 | PRPF4B | 1.05410694 |
| 49 | NTRK1 | 1.04423414 |
| 50 | INSRR | 1.02166082 |
| 51 | OXSR1 | 0.96743067 |
| 52 | ERBB3 | 0.93999103 |
| 53 | MKNK2 | 0.93047503 |
| 54 | STK16 | 0.91763306 |
| 55 | DYRK1A | 0.91199434 |
| 56 | GRK1 | 0.90371962 |
| 57 | TNK2 | 0.88804610 |
| 58 | TXK | 0.88117332 |
| 59 | FER | 0.88073309 |
| 60 | ADRBK2 | 0.81562417 |
| 61 | CAMK2D | 0.81355373 |
| 62 | KSR2 | 0.80990235 |
| 63 | RAF1 | 0.79804237 |
| 64 | SIK3 | 0.79670603 |
| 65 | PRKCE | 0.78863618 |
| 66 | CAMK4 | 0.78360486 |
| 67 | CSNK1G1 | 0.78150669 |
| 68 | PAK6 | 0.75974458 |
| 69 | AKT3 | 0.74282338 |
| 70 | BCR | 0.68770735 |
| 71 | CAMK1 | 0.65850522 |
| 72 | BLK | 0.64558619 |
| 73 | UHMK1 | 0.62787253 |
| 74 | CCNB1 | 0.61202267 |
| 75 | SGK1 | 0.61025316 |
| 76 | PRKD3 | 0.59268931 |
| 77 | STK38L | 0.57738463 |
| 78 | ADRBK1 | 0.57707311 |
| 79 | MAP3K6 | 0.57473600 |
| 80 | CDK3 | 0.57359157 |
| 81 | RPS6KA4 | 0.57171533 |
| 82 | WNK4 | 0.56838227 |
| 83 | ROCK2 | 0.55539717 |
| 84 | BRAF | 0.54378896 |
| 85 | STK38 | 0.53528414 |
| 86 | CAMK2G | 0.52949017 |
| 87 | TLK1 | 0.52248745 |
| 88 | CAMKK2 | 0.49942825 |
| 89 | LIMK1 | 0.49033194 |
| 90 | STK39 | 0.48845703 |
| 91 | RPS6KA3 | 0.47591296 |
| 92 | CDK14 | 0.47582971 |
| 93 | PRKCQ | 0.47405977 |
| 94 | PRKACA | 0.46601335 |
| 95 | NEK6 | 0.45737364 |
| 96 | PKN1 | 0.45512643 |
| 97 | SGK2 | 0.44609850 |
| 98 | STK11 | 0.44488054 |
| 99 | CSNK1D | 0.44045029 |
| 100 | CDK18 | 0.43572702 |
| 101 | YES1 | 0.43106274 |
| 102 | CSNK1A1 | 0.41636666 |
| 103 | PAK3 | 0.41186122 |
| 104 | MAPK4 | 0.41129243 |
| 105 | CDK15 | 0.38445209 |
| 106 | MAPK12 | 0.37389642 |
| 107 | PRKG1 | 0.37052926 |
| 108 | FYN | 0.36938529 |
| 109 | MOS | 0.35447795 |
| 110 | PRKAA1 | 0.34712174 |
| 111 | MAP2K2 | 0.34703404 |
| 112 | CSNK1G2 | 0.34353487 |
| 113 | SYK | 0.34149210 |
| 114 | CDK11A | 0.33902852 |
| 115 | SGK223 | 0.32451459 |
| 116 | SGK494 | 0.32451459 |
| 117 | PRKCA | 0.31526421 |
| 118 | PRKACG | 0.31074777 |
| 119 | ERBB2 | 0.30881383 |
| 120 | PRKACB | 0.30688981 |
| 121 | BMPR1B | 0.30551537 |
| 122 | PHKG1 | 0.30528103 |
| 123 | PHKG2 | 0.30528103 |
| 124 | MAP3K7 | 0.30304994 |
| 125 | PRKCH | 0.30067214 |
| 126 | MAPK10 | 0.29582762 |
| 127 | DMPK | 0.29447019 |
| 128 | PRKD2 | 0.28878204 |
| 129 | MYLK | 0.28396132 |
| 130 | MARK2 | 0.28265620 |
| 131 | PIK3CA | 0.28098392 |
| 132 | BCKDK | 0.27197598 |
| 133 | PRKCZ | 0.27013415 |
| 134 | MAP3K1 | 0.26601076 |
| 135 | DDR2 | 0.26566143 |
| 136 | LATS2 | 0.26277881 |
| 137 | MAP2K1 | 0.26006916 |
| 138 | PRKCB | 0.25170697 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * Nicotine addiction_Homo sapiens_hsa05033 | 4.80627076 |
| 2 | * Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 3.08324283 |
| 3 | Long-term potentiation_Homo sapiens_hsa04720 | 3.01175395 |
| 4 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.77817485 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.61251719 |
| 6 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.60479729 |
| 7 | * Morphine addiction_Homo sapiens_hsa05032 | 2.51363484 |
| 8 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.46920469 |
| 9 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.43977626 |
| 10 | * GABAergic synapse_Homo sapiens_hsa04727 | 2.41285390 |
| 11 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.39678737 |
| 12 | Salivary secretion_Homo sapiens_hsa04970 | 2.36505649 |
| 13 | * Taste transduction_Homo sapiens_hsa04742 | 2.28071176 |
| 14 | Serotonergic synapse_Homo sapiens_hsa04726 | 2.22641884 |
| 15 | Olfactory transduction_Homo sapiens_hsa04740 | 2.21477981 |
| 16 | Renin secretion_Homo sapiens_hsa04924 | 2.12819520 |
| 17 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.07138678 |
| 18 | Long-term depression_Homo sapiens_hsa04730 | 2.05428849 |
| 19 | Calcium signaling pathway_Homo sapiens_hsa04020 | 2.04051032 |
| 20 | Alzheimers disease_Homo sapiens_hsa05010 | 2.02352609 |
| 21 | * Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.89339492 |
| 22 | Phototransduction_Homo sapiens_hsa04744 | 1.76688026 |
| 23 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.69175871 |
| 24 | Parkinsons disease_Homo sapiens_hsa05012 | 1.62625199 |
| 25 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.62517044 |
| 26 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.59420706 |
| 27 | Insulin secretion_Homo sapiens_hsa04911 | 1.57130492 |
| 28 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.51465681 |
| 29 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.50482926 |
| 30 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.46666718 |
| 31 | Huntingtons disease_Homo sapiens_hsa05016 | 1.33295148 |
| 32 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.32018897 |
| 33 | Cocaine addiction_Homo sapiens_hsa05030 | 1.30747513 |
| 34 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.29856811 |
| 35 | Axon guidance_Homo sapiens_hsa04360 | 1.28039888 |
| 36 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.26263396 |
| 37 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.26131609 |
| 38 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.25931477 |
| 39 | Gap junction_Homo sapiens_hsa04540 | 1.17775947 |
| 40 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.16478319 |
| 41 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.13608866 |
| 42 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.12665965 |
| 43 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.05393944 |
| 44 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.02239219 |
| 45 | Melanogenesis_Homo sapiens_hsa04916 | 1.01220592 |
| 46 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.98317786 |
| 47 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.97832731 |
| 48 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.96725710 |
| 49 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.96528149 |
| 50 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.91923003 |
| 51 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.86708137 |
| 52 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.86470311 |
| 53 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.86008148 |
| 54 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.79885360 |
| 55 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.78685291 |
| 56 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.76944577 |
| 57 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.75780414 |
| 58 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.73875690 |
| 59 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.73455001 |
| 60 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.72655772 |
| 61 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.72146388 |
| 62 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.70256378 |
| 63 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.66629871 |
| 64 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.65433502 |
| 65 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.64578249 |
| 66 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.62635179 |
| 67 | Glioma_Homo sapiens_hsa05214 | 0.61881592 |
| 68 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.59814895 |
| 69 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.59691107 |
| 70 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.57207499 |
| 71 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.57047862 |
| 72 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.56605988 |
| 73 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.55464691 |
| 74 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.54884995 |
| 75 | Bile secretion_Homo sapiens_hsa04976 | 0.54609154 |
| 76 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.54242776 |
| 77 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.53531545 |
| 78 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.53358924 |
| 79 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.52654317 |
| 80 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.50222497 |
| 81 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.48466597 |
| 82 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.47964410 |
| 83 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.47275279 |
| 84 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.47054120 |
| 85 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.43991686 |
| 86 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.42472719 |
| 87 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.41711048 |
| 88 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.41143684 |
| 89 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.41052558 |
| 90 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.40461009 |
| 91 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.40228286 |
| 92 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.38659905 |
| 93 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.38008386 |
| 94 | ABC transporters_Homo sapiens_hsa02010 | 0.36481700 |
| 95 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.35686997 |
| 96 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.35599124 |
| 97 | Phagosome_Homo sapiens_hsa04145 | 0.35055182 |
| 98 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.34219401 |
| 99 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.34089350 |
| 100 | Histidine metabolism_Homo sapiens_hsa00340 | 0.33617640 |
| 101 | Alcoholism_Homo sapiens_hsa05034 | 0.33008090 |
| 102 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.32935324 |
| 103 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.32407098 |
| 104 | Prion diseases_Homo sapiens_hsa05020 | 0.32278715 |
| 105 | Protein export_Homo sapiens_hsa03060 | 0.30991116 |
| 106 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.30576650 |
| 107 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.29681706 |
| 108 | Mineral absorption_Homo sapiens_hsa04978 | 0.29634816 |
| 109 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.28587752 |
| 110 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.24760637 |
| 111 | Retinol metabolism_Homo sapiens_hsa00830 | 0.24506633 |
| 112 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.23235093 |
| 113 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.22021409 |
| 114 | Circadian rhythm_Homo sapiens_hsa04710 | 0.21257896 |
| 115 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.21061512 |
| 116 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.20632165 |
| 117 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.19306894 |
| 118 | Melanoma_Homo sapiens_hsa05218 | 0.18538255 |
| 119 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.18232131 |
| 120 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.15379754 |
| 121 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.14669253 |
| 122 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.14199847 |
| 123 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.11125134 |
| 124 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.10247290 |
| 125 | Salmonella infection_Homo sapiens_hsa05132 | 0.08140667 |
| 126 | Tuberculosis_Homo sapiens_hsa05152 | 0.08130642 |
| 127 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.07966707 |

