GABRB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.06684677
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.68911095
3locomotory exploration behavior (GO:0035641)5.59057427
4synaptic vesicle maturation (GO:0016188)5.52210618
5vocalization behavior (GO:0071625)5.48912548
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.46442744
7synaptic vesicle exocytosis (GO:0016079)5.44488691
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.35888350
9protein localization to synapse (GO:0035418)5.17432673
10ionotropic glutamate receptor signaling pathway (GO:0035235)5.04838357
11regulation of glutamate receptor signaling pathway (GO:1900449)5.00853562
12glutamate secretion (GO:0014047)4.94842968
13neuron cell-cell adhesion (GO:0007158)4.91885168
14regulation of synaptic vesicle exocytosis (GO:2000300)4.89201918
15exploration behavior (GO:0035640)4.71554584
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.71366886
17glutamate receptor signaling pathway (GO:0007215)4.65203050
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.49235525
19synaptic transmission, glutamatergic (GO:0035249)4.43310340
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.42747419
21regulation of synaptic vesicle transport (GO:1902803)4.37344667
22regulation of neuronal synaptic plasticity (GO:0048168)4.36286213
23neuron-neuron synaptic transmission (GO:0007270)4.24681354
24layer formation in cerebral cortex (GO:0021819)4.23611886
25neurotransmitter-gated ion channel clustering (GO:0072578)4.21605967
26regulation of synapse structural plasticity (GO:0051823)4.21165075
27neurotransmitter secretion (GO:0007269)4.16258086
28dendritic spine morphogenesis (GO:0060997)4.11070805
29neuronal action potential propagation (GO:0019227)4.06190711
30regulation of excitatory postsynaptic membrane potential (GO:0060079)4.04699514
31positive regulation of synapse maturation (GO:0090129)3.95753237
32neuron recognition (GO:0008038)3.93184747
33pyrimidine nucleobase catabolic process (GO:0006208)3.92243291
34long-term memory (GO:0007616)3.91412506
35regulation of postsynaptic membrane potential (GO:0060078)3.89338757
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.86604113
37positive regulation of membrane potential (GO:0045838)3.83342426
38cellular potassium ion homeostasis (GO:0030007)3.82283584
39gamma-aminobutyric acid signaling pathway (GO:0007214)3.78494712
40proline transport (GO:0015824)3.75402149
41regulation of dendritic spine morphogenesis (GO:0061001)3.71151096
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.69076244
43regulation of synaptic plasticity (GO:0048167)3.67664098
44behavioral defense response (GO:0002209)3.67027674
45behavioral fear response (GO:0001662)3.67027674
46long-term synaptic potentiation (GO:0060291)3.65343091
47axonal fasciculation (GO:0007413)3.63235477
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.62897376
49synaptic vesicle endocytosis (GO:0048488)3.60929668
50postsynaptic membrane organization (GO:0001941)3.60904738
51presynaptic membrane assembly (GO:0097105)3.57806858
52gamma-aminobutyric acid transport (GO:0015812)3.52415461
53regulation of synaptic transmission, glutamatergic (GO:0051966)3.49493687
54transmission of nerve impulse (GO:0019226)3.48151130
55neurotransmitter transport (GO:0006836)3.45213710
56positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.43120536
57fear response (GO:0042596)3.41799989
58nucleobase catabolic process (GO:0046113)3.39840179
59positive regulation of neurotransmitter secretion (GO:0001956)3.38658657
60dendrite morphogenesis (GO:0048813)3.37440275
61mechanosensory behavior (GO:0007638)3.36004695
62regulation of vesicle fusion (GO:0031338)3.36002226
63regulation of neurotransmitter secretion (GO:0046928)3.35075274
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.33725602
65sodium ion export (GO:0071436)3.32016716
66positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.31413522
67positive regulation of dendritic spine morphogenesis (GO:0061003)3.29968126
68presynaptic membrane organization (GO:0097090)3.27110108
69regulation of gene silencing by RNA (GO:0060966)3.25910205
70regulation of posttranscriptional gene silencing (GO:0060147)3.25910205
71regulation of gene silencing by miRNA (GO:0060964)3.25910205
72activation of protein kinase A activity (GO:0034199)3.25389205
73negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25089512
74neuromuscular process controlling balance (GO:0050885)3.24012737
75membrane depolarization (GO:0051899)3.23238361
76regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.22152498
77synapse assembly (GO:0007416)3.21632208
78learning (GO:0007612)3.21595098
79cerebellar Purkinje cell differentiation (GO:0021702)3.20676746
80auditory behavior (GO:0031223)3.20487421
81G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.20045833
82positive regulation of neurotransmitter transport (GO:0051590)3.18679895
83membrane hyperpolarization (GO:0060081)3.18077268
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17642871
85regulation of dendritic spine development (GO:0060998)3.16969601
86startle response (GO:0001964)3.16834434
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.16041558
88prepulse inhibition (GO:0060134)3.14227791
89atrial cardiac muscle cell action potential (GO:0086014)3.13180356
90positive regulation of dendritic spine development (GO:0060999)3.12895564
91regulation of neurotransmitter levels (GO:0001505)3.11923571
92dendritic spine organization (GO:0097061)3.11665511
93membrane depolarization during action potential (GO:0086010)3.11043133
94regulation of neurotransmitter transport (GO:0051588)3.09130429
95cerebellar granule cell differentiation (GO:0021707)3.07284213
96* innervation (GO:0060384)3.06855056
97negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.06458082
98negative regulation of translation, ncRNA-mediated (GO:0040033)3.06458082
99regulation of translation, ncRNA-mediated (GO:0045974)3.06458082
100regulation of synapse maturation (GO:0090128)3.05025060
101long term synaptic depression (GO:0060292)3.04378207
102response to auditory stimulus (GO:0010996)3.03844258
103vesicle transport along microtubule (GO:0047496)3.03582586
104cell communication by electrical coupling (GO:0010644)3.03018983
105positive regulation of synaptic transmission (GO:0050806)3.01472137
106behavioral response to cocaine (GO:0048148)3.01154291
107central nervous system projection neuron axonogenesis (GO:0021952)3.00091921
108regulation of synaptic transmission (GO:0050804)2.98678489
109behavioral response to nicotine (GO:0035095)2.98558529
110* synaptic transmission (GO:0007268)2.98135858
111intraspecies interaction between organisms (GO:0051703)2.97386905
112neurofilament cytoskeleton organization (GO:0060052)2.94077989
113negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83418237
114establishment of mitochondrion localization (GO:0051654)2.73122371
115positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.71612839
116pre-miRNA processing (GO:0031054)2.70293829
117neuronal ion channel clustering (GO:0045161)2.66395491
118regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.65096192
119serotonin metabolic process (GO:0042428)2.57706847
120neuromuscular process controlling posture (GO:0050884)2.54690332
121* cochlea development (GO:0090102)2.53666507
122adult walking behavior (GO:0007628)2.53436225
123cell migration in hindbrain (GO:0021535)2.48712946
124neuromuscular synaptic transmission (GO:0007274)2.47611627
125synapse organization (GO:0050808)2.45940630
126social behavior (GO:0035176)2.42519777
127adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.39072833
128C4-dicarboxylate transport (GO:0015740)2.38857486
129adult behavior (GO:0030534)2.38435141
130establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.38090575
131mitochondrion transport along microtubule (GO:0047497)2.38090575
132cerebellum development (GO:0021549)2.37548756
133positive regulation of synapse assembly (GO:0051965)2.37242670

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.07394668
2GBX2_23144817_ChIP-Seq_PC3_Human3.93501984
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13929732
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09021713
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02658321
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.76213019
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64687360
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64687360
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60903489
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58120168
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.54496408
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.51999267
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50545008
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46900193
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44686653
16DROSHA_22980978_ChIP-Seq_HELA_Human2.41464799
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41269254
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.25172683
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19994228
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.19497655
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.18136313
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17843682
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.16050896
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.03743727
25AR_21572438_ChIP-Seq_LNCaP_Human1.99545418
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99258847
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99227152
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98734149
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91570503
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90661006
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88708156
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86217923
33* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80613290
34TAF15_26573619_Chip-Seq_HEK293_Human1.79552005
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78701678
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.76409245
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.76055068
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70976351
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65232791
40* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63428317
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63280044
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61921474
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.58146287
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57913962
45EWS_26573619_Chip-Seq_HEK293_Human1.55634231
46P300_19829295_ChIP-Seq_ESCs_Human1.54312377
47ZNF274_21170338_ChIP-Seq_K562_Hela1.49952542
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.49737249
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48642414
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.42217344
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41393076
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.37238196
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35706439
54AR_25329375_ChIP-Seq_VCAP_Human1.34479578
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34430286
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33208452
57SOX2_16153702_ChIP-ChIP_HESCs_Human1.33141818
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33136354
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.32436030
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.32403254
61IGF1R_20145208_ChIP-Seq_DFB_Human1.31498019
62* STAT3_23295773_ChIP-Seq_U87_Human1.29509199
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29133588
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29035033
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.28548603
66* RING1B_27294783_Chip-Seq_ESCs_Mouse1.27306696
67FUS_26573619_Chip-Seq_HEK293_Human1.26435130
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.26316917
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.26298181
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25788797
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25468804
72AR_19668381_ChIP-Seq_PC3_Human1.24039745
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22766434
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22230671
75* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19889997
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19575152
77* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19358749
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18176900
79RNF2_27304074_Chip-Seq_NSC_Mouse1.16452748
80TCF4_23295773_ChIP-Seq_U87_Human1.15472351
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14337730
82STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13806699
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.13670834
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13630951
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13226787
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12185531
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11507784
88TP53_16413492_ChIP-PET_HCT116_Human1.11426446
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11324881
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11045168
91SOX9_26525672_Chip-Seq_HEART_Mouse1.10685125
92CBP_20019798_ChIP-Seq_JUKART_Human1.10669205
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10669205
94* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10579434
95* ARNT_22903824_ChIP-Seq_MCF-7_Human1.09843966
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08921141
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08530475
98* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05408328
99AHR_22903824_ChIP-Seq_MCF-7_Human1.05385121
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04051790
101RUNX2_22187159_ChIP-Seq_PCA_Human1.03705476
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01933709
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01857428
104KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01697969
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01634581
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00952875
107POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00205594
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99605764
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99569842
110DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99469537
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98757157
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98757157
113TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98221527
114TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97136378
115SMAD3_21741376_ChIP-Seq_ESCs_Human0.96638168
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95873403
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95835936
118TCF4_22108803_ChIP-Seq_LS180_Human0.95791590
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95552565
120* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95061002
121* JUN_21703547_ChIP-Seq_K562_Human0.95058778
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94247182
123NANOG_18555785_Chip-Seq_ESCs_Mouse0.93276976
124ER_23166858_ChIP-Seq_MCF-7_Human0.93023371
125* SMAD4_21741376_ChIP-Seq_HESCs_Human0.92178678
126* SMAD3_21741376_ChIP-Seq_HESCs_Human0.92006657
127BCAT_22108803_ChIP-Seq_LS180_Human0.90984754
128VDR_22108803_ChIP-Seq_LS180_Human0.90549556
129TP53_18474530_ChIP-ChIP_U2OS_Human0.90065900
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90024651

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.68053777
2MP0003880_abnormal_central_pattern5.08888338
3* MP0003635_abnormal_synaptic_transmissio4.23081175
4MP0004270_analgesia3.88957942
5MP0002063_abnormal_learning/memory/cond3.52651842
6* MP0009745_abnormal_behavioral_response3.39932063
7* MP0002064_seizures3.08765169
8MP0001968_abnormal_touch/_nociception3.06369891
9* MP0002572_abnormal_emotion/affect_behav2.88172581
10MP0009046_muscle_twitch2.87861783
11MP0008877_abnormal_DNA_methylation2.80257166
12MP0005423_abnormal_somatic_nervous2.79179954
13MP0001486_abnormal_startle_reflex2.61696651
14MP0002734_abnormal_mechanical_nocicepti2.61355151
15MP0002822_catalepsy2.53755935
16* MP0002272_abnormal_nervous_system2.47937461
17MP0002736_abnormal_nociception_after2.29547473
18MP0002735_abnormal_chemical_nociception2.28691903
19MP0001501_abnormal_sleep_pattern2.22723624
20MP0001440_abnormal_grooming_behavior2.20178266
21MP0003123_paternal_imprinting2.12994707
22MP0003121_genomic_imprinting2.09979998
23MP0000778_abnormal_nervous_system1.99808007
24MP0009780_abnormal_chondrocyte_physiolo1.99333812
25MP0003890_abnormal_embryonic-extraembry1.98108616
26* MP0002067_abnormal_sensory_capabilities1.96073467
27MP0002733_abnormal_thermal_nociception1.94436393
28MP0001970_abnormal_pain_threshold1.89100224
29* MP0002184_abnormal_innervation1.82596232
30MP0005386_behavior/neurological_phenoty1.82166345
31MP0004924_abnormal_behavior1.82166345
32MP0002909_abnormal_adrenal_gland1.81721091
33MP0002557_abnormal_social/conspecific_i1.80687008
34MP0003329_amyloid_beta_deposits1.80153538
35MP0004811_abnormal_neuron_physiology1.78015237
36MP0001984_abnormal_olfaction1.65516192
37MP0006276_abnormal_autonomic_nervous1.64698023
38MP0005646_abnormal_pituitary_gland1.59390778
39MP0003879_abnormal_hair_cell1.58649548
40MP0004858_abnormal_nervous_system1.57964734
41* MP0008569_lethality_at_weaning1.56961621
42MP0003787_abnormal_imprinting1.56439774
43MP0000955_abnormal_spinal_cord1.53468102
44MP0001529_abnormal_vocalization1.50673581
45MP0004133_heterotaxia1.46231599
46* MP0002882_abnormal_neuron_morphology1.45915406
47MP0001188_hyperpigmentation1.43909536
48MP0001502_abnormal_circadian_rhythm1.41434897
49* MP0002066_abnormal_motor_capabilities/c1.41068247
50MP0005551_abnormal_eye_electrophysiolog1.37242126
51MP0004885_abnormal_endolymph1.36561393
52MP0003119_abnormal_digestive_system1.34885304
53MP0005645_abnormal_hypothalamus_physiol1.33766464
54MP0003633_abnormal_nervous_system1.31145072
55MP0002751_abnormal_autonomic_nervous1.19641752
56MP0002102_abnormal_ear_morphology1.19629341
57MP0001905_abnormal_dopamine_level1.17865421
58* MP0002152_abnormal_brain_morphology1.15398392
59MP0003136_yellow_coat_color1.15284986
60MP0000569_abnormal_digit_pigmentation1.14483387
61MP0002938_white_spotting1.10953993
62MP0002254_reproductive_system_inflammat1.10792441
63MP0004142_abnormal_muscle_tone1.10745460
64MP0003631_nervous_system_phenotype1.09976411
65MP0003122_maternal_imprinting1.09386118
66MP0010386_abnormal_urinary_bladder1.01624160
67MP0003941_abnormal_skin_development0.98165360
68* MP0002229_neurodegeneration0.98128436
69MP0003567_abnormal_fetal_cardiomyocyte0.95942855
70MP0000631_abnormal_neuroendocrine_gland0.95694396
71MP0004145_abnormal_muscle_electrophysio0.95691132
72MP0002090_abnormal_vision0.95196941
73* MP0002069_abnormal_eating/drinking_beha0.94169383
74MP0003937_abnormal_limbs/digits/tail_de0.92625439
75MP0005499_abnormal_olfactory_system0.92351714
76MP0005394_taste/olfaction_phenotype0.92351714
77MP0004742_abnormal_vestibular_system0.91232330
78MP0008872_abnormal_physiological_respon0.91013695
79MP0005409_darkened_coat_color0.89202406
80MP0002837_dystrophic_cardiac_calcinosis0.89080660
81MP0002653_abnormal_ependyma_morphology0.88945902
82MP0005379_endocrine/exocrine_gland_phen0.86198519
83MP0004085_abnormal_heartbeat0.85705725
84MP0009672_abnormal_birth_weight0.85416597
85MP0008874_decreased_physiological_sensi0.84852354
86MP0004215_abnormal_myocardial_fiber0.83330306
87MP0000751_myopathy0.82682642
88MP0001299_abnormal_eye_distance/0.81762496
89MP0000013_abnormal_adipose_tissue0.81607206
90MP0001293_anophthalmia0.81503525
91* MP0002752_abnormal_somatic_nervous0.80699233
92MP0001177_atelectasis0.80462413
93MP0003634_abnormal_glial_cell0.80426116
94MP0005535_abnormal_body_temperature0.79792419
95MP0002876_abnormal_thyroid_physiology0.79190004
96MP0008058_abnormal_DNA_repair0.79141797
97MP0003011_delayed_dark_adaptation0.77892127
98MP0006072_abnormal_retinal_apoptosis0.77834589
99MP0008057_abnormal_DNA_replication0.77506651
100MP0002163_abnormal_gland_morphology0.76287161
101MP0008961_abnormal_basal_metabolism0.76107508
102MP0000604_amyloidosis0.75581168
103MP0000566_synostosis0.75523467
104* MP0001963_abnormal_hearing_physiology0.75504237
105MP0003632_abnormal_nervous_system0.73269108
106MP0000647_abnormal_sebaceous_gland0.73141387
107MP0004147_increased_porphyrin_level0.70504611
108MP0000049_abnormal_middle_ear0.69278956
109MP0004233_abnormal_muscle_weight0.69115540
110MP0003075_altered_response_to0.69058573
111MP0003283_abnormal_digestive_organ0.69031763
112MP0005187_abnormal_penis_morphology0.67933946
113MP0004484_altered_response_of0.67402668
114MP0003861_abnormal_nervous_system0.63871067
115MP0003137_abnormal_impulse_conducting0.62608453
116MP0000920_abnormal_myelination0.62314387
117MP0001664_abnormal_digestion0.62111965
118MP0004510_myositis0.61491067
119MP0002234_abnormal_pharynx_morphology0.59101269
120MP0002638_abnormal_pupillary_reflex0.59049599
121MP0003690_abnormal_glial_cell0.58883128
122MP0005253_abnormal_eye_physiology0.58774233
123MP0006292_abnormal_olfactory_placode0.58291173
124MP0001485_abnormal_pinna_reflex0.58032295
125MP0001943_abnormal_respiration0.55142934
126MP0010234_abnormal_vibrissa_follicle0.53083522
127* MP0010769_abnormal_survival0.52350236

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.80945523
2Myokymia (HP:0002411)6.39095157
3Focal seizures (HP:0007359)5.80622157
4Epileptic encephalopathy (HP:0200134)5.33642887
5Visual hallucinations (HP:0002367)5.27117004
6Febrile seizures (HP:0002373)4.60231145
7Atonic seizures (HP:0010819)4.49473089
8Progressive cerebellar ataxia (HP:0002073)4.45806985
9Hyperventilation (HP:0002883)3.98914162
10Abnormality of the labia minora (HP:0012880)3.94631131
11Broad-based gait (HP:0002136)3.90723009
12Generalized tonic-clonic seizures (HP:0002069)3.90599030
13* Absence seizures (HP:0002121)3.74204601
14Action tremor (HP:0002345)3.72146895
15Poor eye contact (HP:0000817)3.54944297
16Supranuclear gaze palsy (HP:0000605)3.51388990
17* Dialeptic seizures (HP:0011146)3.49120482
18Gaze-evoked nystagmus (HP:0000640)3.27796783
19Excessive salivation (HP:0003781)3.25555543
20Drooling (HP:0002307)3.25555543
21Impaired vibration sensation in the lower limbs (HP:0002166)3.22119601
22Truncal ataxia (HP:0002078)3.21103231
23Mutism (HP:0002300)3.20424732
24Abnormal social behavior (HP:0012433)3.18332147
25Impaired social interactions (HP:0000735)3.18332147
26Depression (HP:0000716)3.17913371
27Dysdiadochokinesis (HP:0002075)3.15500792
28Papilledema (HP:0001085)3.13228681
29Amblyopia (HP:0000646)3.10332242
30Urinary bladder sphincter dysfunction (HP:0002839)3.07184857
31Ankle clonus (HP:0011448)3.02128760
32Dysmetria (HP:0001310)3.01970306
33Anxiety (HP:0000739)2.99692679
34Genetic anticipation (HP:0003743)2.94623262
35Hepatoblastoma (HP:0002884)2.91917726
36Epileptiform EEG discharges (HP:0011182)2.90009220
37Cerebral inclusion bodies (HP:0100314)2.82695841
38Impaired smooth pursuit (HP:0007772)2.78730678
39Abnormal eating behavior (HP:0100738)2.76573184
40Hemiparesis (HP:0001269)2.75951930
41Postural instability (HP:0002172)2.72192052
42Neurofibrillary tangles (HP:0002185)2.69665013
43Colon cancer (HP:0003003)2.68131174
44EEG with generalized epileptiform discharges (HP:0011198)2.67923185
45Abnormality of the lower motor neuron (HP:0002366)2.64587831
46Absent speech (HP:0001344)2.63936126
47Stereotypic behavior (HP:0000733)2.59812556
48Abnormality of binocular vision (HP:0011514)2.59270800
49Diplopia (HP:0000651)2.59270800
50Urinary urgency (HP:0000012)2.59157225
51Scanning speech (HP:0002168)2.56265900
52Progressive inability to walk (HP:0002505)2.51113256
53Insidious onset (HP:0003587)2.49824425
54Termporal pattern (HP:0011008)2.49824425
55Hypsarrhythmia (HP:0002521)2.48014412
56Torticollis (HP:0000473)2.47042502
57Spastic gait (HP:0002064)2.46602117
58Abnormality of the corticospinal tract (HP:0002492)2.44618876
59Abnormality of ocular smooth pursuit (HP:0000617)2.43336581
60Amyotrophic lateral sclerosis (HP:0007354)2.39097849
61Bradykinesia (HP:0002067)2.38490700
62Fetal akinesia sequence (HP:0001989)2.33605375
63Septo-optic dysplasia (HP:0100842)2.32719565
64Focal dystonia (HP:0004373)2.31461189
65Inability to walk (HP:0002540)2.31214165
66Intestinal atresia (HP:0011100)2.29806899
67Dysmetric saccades (HP:0000641)2.28243812
68Neoplasm of the adrenal cortex (HP:0100641)2.27006662
69Intention tremor (HP:0002080)2.26576676
70Megalencephaly (HP:0001355)2.26117024
71Generalized myoclonic seizures (HP:0002123)2.23528550
72Poor suck (HP:0002033)2.23195247
73Polyphagia (HP:0002591)2.22170511
74Hyperinsulinemic hypoglycemia (HP:0000825)2.21199382
75Inappropriate behavior (HP:0000719)2.20917095
76Impaired vibratory sensation (HP:0002495)2.19685252
77Protruding tongue (HP:0010808)2.15999679
78Agitation (HP:0000713)2.15506179
79Hypoglycemic seizures (HP:0002173)2.15054275
80Abnormality of salivation (HP:0100755)2.14727360
81Status epilepticus (HP:0002133)2.12775369
82Limb dystonia (HP:0002451)2.12239177
83Lower limb muscle weakness (HP:0007340)2.07770147
84Sleep apnea (HP:0010535)2.06871682
85Blue irides (HP:0000635)2.05046464
86Pancreatic fibrosis (HP:0100732)2.03097693
87Optic nerve hypoplasia (HP:0000609)2.02381416
88Central scotoma (HP:0000603)2.02332158
89Craniofacial dystonia (HP:0012179)2.02080557
90Cortical dysplasia (HP:0002539)2.01349376
91Pheochromocytoma (HP:0002666)1.98964016
92Hypothermia (HP:0002045)1.98048530
93Genital tract atresia (HP:0001827)1.97489198
94Hemiplegia (HP:0002301)1.95927849
95Incomplete penetrance (HP:0003829)1.94728743
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94344144
97Vaginal atresia (HP:0000148)1.92211145
98Obstructive sleep apnea (HP:0002870)1.91427639
99Gait imbalance (HP:0002141)1.90586200
100Gait ataxia (HP:0002066)1.89685247
101Ventricular fibrillation (HP:0001663)1.88146546
102Medial flaring of the eyebrow (HP:0010747)1.87630723
103Nephronophthisis (HP:0000090)1.85771645
104Pointed chin (HP:0000307)1.83326076
105Psychosis (HP:0000709)1.83134754
106Hyperglycinemia (HP:0002154)1.81075341
107Ankyloglossia (HP:0010296)1.80762799
108Bilateral microphthalmos (HP:0007633)1.80362666
109Abnormal EKG (HP:0003115)1.79501853
110Delusions (HP:0000746)1.79083087
111Congenital stationary night blindness (HP:0007642)1.78513744
112Aqueductal stenosis (HP:0002410)1.78307229
113Failure to thrive in infancy (HP:0001531)1.78301391
114Lissencephaly (HP:0001339)1.77863316
115Neuronal loss in central nervous system (HP:0002529)1.76657520
116Widely spaced teeth (HP:0000687)1.76267448
117Restlessness (HP:0000711)1.75466685
118Akinesia (HP:0002304)1.75086829
119Molar tooth sign on MRI (HP:0002419)1.74625938
120Abnormality of midbrain morphology (HP:0002418)1.74625938
121Generalized hypopigmentation of hair (HP:0011358)1.74532743
122Labial hypoplasia (HP:0000066)1.73954017
123Hypoglycemic coma (HP:0001325)1.73296159
124Pancreatic cysts (HP:0001737)1.72636952
125Lower limb amyotrophy (HP:0007210)1.71917045
126Specific learning disability (HP:0001328)1.71066992
127Autism (HP:0000717)1.70023706
128Lower limb asymmetry (HP:0100559)1.69585224
129Annular pancreas (HP:0001734)1.69528246
130Methylmalonic acidemia (HP:0002912)1.69096529
131Muscular hypotonia of the trunk (HP:0008936)1.67726609
132Spastic tetraplegia (HP:0002510)1.67057708
133Gastrointestinal atresia (HP:0002589)1.66751458
134Abnormal hair whorl (HP:0010721)1.66566332
135Congenital primary aphakia (HP:0007707)1.65861879
136True hermaphroditism (HP:0010459)1.65727986
137Hypoplastic female external genitalia (HP:0012815)1.64471248
138Hypogonadotrophic hypogonadism (HP:0000044)1.64105044
139Absent eyebrow (HP:0002223)1.63578215
140Cerebral hypomyelination (HP:0006808)1.62965967
141Hypomagnesemia (HP:0002917)1.61486478
142Abnormal pancreas size (HP:0012094)1.59883862
143Birth length less than 3rd percentile (HP:0003561)1.59673417
144Absent septum pellucidum (HP:0001331)1.58929516
145Growth hormone deficiency (HP:0000824)1.57563004
146Acute necrotizing encephalopathy (HP:0006965)1.57550076
147Glioma (HP:0009733)1.55734392
148Abolished electroretinogram (ERG) (HP:0000550)1.55620117
149Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.55596266
150Degeneration of the lateral corticospinal tracts (HP:0002314)1.55596266
151Neoplasm of the adrenal gland (HP:0100631)1.54702722

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.73461294
2EPHA44.58798141
3MARK13.84938549
4MAP3K93.72076718
5MAP3K43.13134838
6MINK12.68932004
7MAP2K72.58681320
8DAPK22.30359233
9RIPK42.25560220
10CASK2.18409757
11PAK62.16042619
12DYRK22.09173567
13MKNK22.03609885
14KSR22.03071635
15NTRK22.02189818
16FRK1.91284416
17KSR11.85364928
18MAP2K41.85035357
19MAP3K121.84922112
20DAPK11.75738373
21ZAK1.74244989
22TSSK61.67362684
23TNIK1.62858583
24PRKD31.61894938
25CAMKK11.60896853
26NTRK11.60445251
27PLK21.58171995
28PNCK1.56124332
29CDK51.55511254
30BMPR1B1.47521120
31MAPK131.47505453
32TRIM281.47092402
33SIK21.42313453
34FGFR21.38579785
35PLK31.37802088
36PRPF4B1.37151427
37CSNK1G11.32000290
38MKNK11.29900063
39CDK191.29660364
40CDC71.29009152
41GRK51.28298030
42PRKCG1.26228660
43MAP3K21.21333108
44CSNK1G31.19388443
45STK381.17167826
46FES1.14732859
47MAP4K21.09852577
48TTK1.08175499
49ARAF1.06734117
50PHKG11.02601386
51PHKG21.02601386
52* CAMK2A1.02330422
53UHMK11.01564069
54TAF11.01552165
55CAMK2B0.99812011
56MAP3K130.99782626
57BMPR20.97652152
58CAMKK20.96789309
59LATS20.92918925
60ADRBK20.92109370
61CAMK1D0.92002890
62SRPK10.91895867
63CDK180.90966840
64CDK140.88491710
65CDK150.87859702
66NUAK10.87781659
67CSNK1A1L0.87094903
68INSRR0.86942732
69SGK2230.86736436
70SGK4940.86736436
71GRK10.85813276
72RAF10.84499731
73CAMK10.83191128
74TYRO30.83189248
75DYRK1A0.82708633
76STK160.81962107
77STK110.80652653
78PTK2B0.80280830
79PLK40.77971076
80DYRK30.77850364
81PAK30.77581695
82SGK20.76754449
83SGK10.76446566
84CDK11A0.76319888
85RET0.75702352
86ACVR1B0.75436026
87CSNK1G20.74870050
88NME10.73439176
89CSNK1E0.72836269
90OXSR10.71902984
91TAOK10.70758737
92STK38L0.69675770
93VRK10.67945676
94PLK10.67350281
95WNK30.64316677
96PRKCH0.64309700
97MARK20.64089184
98CCNB10.61347006
99PDK10.60169676
100SGK30.59438251
101BUB10.58999636
102PRKCZ0.56807003
103CAMK2D0.53498146
104PRKCE0.52685042
105MAP3K60.52114728
106AKT30.51151812
107PDPK10.50780730
108ERBB30.50724452
109MAP3K10.49425087
110CAMK1G0.49282929
111PINK10.49143311
112CSNK1D0.48965314
113CDK30.48846408
114RPS6KA30.48748576
115FGR0.48160558
116WNK40.48098049
117CSNK1A10.47755727
118PASK0.46363332
119FER0.46333298
120PRKDC0.46274334
121FYN0.46122935
122MAP3K70.44522344
123ALK0.44164749
124MAPK100.42942328
125BCR0.42036119
126SIK30.41738250
127BRSK10.41470842
128ATM0.40729438
129MAP2K10.38090090
130MAPK120.37696269
131PRKG10.36889745
132CAMK2G0.36827793
133PRKACA0.36331588
134PRKCB0.35421052
135CDC42BPA0.35079745
136LMTK20.34844817
137SCYL20.34629485
138NEK60.34597648
139GSK3B0.34292741
140CAMK40.32238861
141NEK10.32136655
142DMPK0.31876701
143PKN10.29813818

Predicted pathways (KEGG)

RankGene SetZ-score
1* Nicotine addiction_Homo sapiens_hsa050333.87106510
2Synaptic vesicle cycle_Homo sapiens_hsa047213.09244214
3Long-term potentiation_Homo sapiens_hsa047202.88696747
4Circadian entrainment_Homo sapiens_hsa047132.84150043
5* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74029068
6Glutamatergic synapse_Homo sapiens_hsa047242.69150567
7* GABAergic synapse_Homo sapiens_hsa047272.67102242
8Olfactory transduction_Homo sapiens_hsa047402.66577455
9Amphetamine addiction_Homo sapiens_hsa050312.60430812
10* Morphine addiction_Homo sapiens_hsa050322.51835282
11Dopaminergic synapse_Homo sapiens_hsa047282.26972289
12Salivary secretion_Homo sapiens_hsa049702.24231321
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21385567
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14791677
15Insulin secretion_Homo sapiens_hsa049112.05700341
16Cholinergic synapse_Homo sapiens_hsa047251.95484635
17Renin secretion_Homo sapiens_hsa049241.86424777
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85656640
19Gastric acid secretion_Homo sapiens_hsa049711.83989261
20Taste transduction_Homo sapiens_hsa047421.81326725
21Long-term depression_Homo sapiens_hsa047301.78840517
22Oxytocin signaling pathway_Homo sapiens_hsa049211.74692369
23* Serotonergic synapse_Homo sapiens_hsa047261.71208705
24Cocaine addiction_Homo sapiens_hsa050301.68299453
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64801041
26Oxidative phosphorylation_Homo sapiens_hsa001901.63635762
27Calcium signaling pathway_Homo sapiens_hsa040201.62723328
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.61279376
29Vitamin B6 metabolism_Homo sapiens_hsa007501.57416589
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51465823
31Protein export_Homo sapiens_hsa030601.51077584
32Steroid biosynthesis_Homo sapiens_hsa001001.49595739
33GnRH signaling pathway_Homo sapiens_hsa049121.49191891
34Butanoate metabolism_Homo sapiens_hsa006501.46906616
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46474466
36Collecting duct acid secretion_Homo sapiens_hsa049661.40860242
37Gap junction_Homo sapiens_hsa045401.40566094
38Parkinsons disease_Homo sapiens_hsa050121.40013106
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39180901
40cAMP signaling pathway_Homo sapiens_hsa040241.29742439
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28572982
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27957963
43Phototransduction_Homo sapiens_hsa047441.24632783
44Axon guidance_Homo sapiens_hsa043601.22776000
45Type II diabetes mellitus_Homo sapiens_hsa049301.21977630
46Glioma_Homo sapiens_hsa052141.17922361
47Selenocompound metabolism_Homo sapiens_hsa004501.16216317
48RNA polymerase_Homo sapiens_hsa030201.15592283
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15215783
50Estrogen signaling pathway_Homo sapiens_hsa049151.13979264
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13616212
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10641746
53* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05948806
54ErbB signaling pathway_Homo sapiens_hsa040121.04941728
55Melanogenesis_Homo sapiens_hsa049161.04538747
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01609348
57Propanoate metabolism_Homo sapiens_hsa006401.01051580
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00210245
59Huntingtons disease_Homo sapiens_hsa050160.99781036
60Non-homologous end-joining_Homo sapiens_hsa034500.97381108
61Cardiac muscle contraction_Homo sapiens_hsa042600.96936427
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.95950587
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92711576
64Basal transcription factors_Homo sapiens_hsa030220.91717482
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91640424
66Oocyte meiosis_Homo sapiens_hsa041140.90514308
67Vibrio cholerae infection_Homo sapiens_hsa051100.89933521
68Pancreatic secretion_Homo sapiens_hsa049720.86262302
69Dorso-ventral axis formation_Homo sapiens_hsa043200.82777407
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82429092
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.81649280
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79396563
73Choline metabolism in cancer_Homo sapiens_hsa052310.78098570
74RNA degradation_Homo sapiens_hsa030180.78068485
75Thyroid hormone synthesis_Homo sapiens_hsa049180.77157422
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.77111835
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77019615
78Ether lipid metabolism_Homo sapiens_hsa005650.76754924
79Mismatch repair_Homo sapiens_hsa034300.75440437
80MAPK signaling pathway_Homo sapiens_hsa040100.72498852
81VEGF signaling pathway_Homo sapiens_hsa043700.72175964
82beta-Alanine metabolism_Homo sapiens_hsa004100.71210239
83Dilated cardiomyopathy_Homo sapiens_hsa054140.70335608
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68364039
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67263987
86Hippo signaling pathway_Homo sapiens_hsa043900.66543095
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66516175
88RNA transport_Homo sapiens_hsa030130.66219785
89Tryptophan metabolism_Homo sapiens_hsa003800.65973567
90Pyruvate metabolism_Homo sapiens_hsa006200.65641566
91Tight junction_Homo sapiens_hsa045300.65233121
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64218733
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63973551
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63825151
95mRNA surveillance pathway_Homo sapiens_hsa030150.63381393
96Ras signaling pathway_Homo sapiens_hsa040140.62208073
97Glucagon signaling pathway_Homo sapiens_hsa049220.60567641
98mTOR signaling pathway_Homo sapiens_hsa041500.58635017
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.58392174
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57418180
101Rap1 signaling pathway_Homo sapiens_hsa040150.55220031
102Alcoholism_Homo sapiens_hsa050340.55181353
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55019457
104Circadian rhythm_Homo sapiens_hsa047100.54503036
105Homologous recombination_Homo sapiens_hsa034400.53631943
106Fanconi anemia pathway_Homo sapiens_hsa034600.53586383
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.52616018
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52533676
109Regulation of autophagy_Homo sapiens_hsa041400.52272794
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51639193
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51342798
112Folate biosynthesis_Homo sapiens_hsa007900.50811325
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50785955
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50571644
115Hedgehog signaling pathway_Homo sapiens_hsa043400.50488165
116Fatty acid metabolism_Homo sapiens_hsa012120.50049538
117Purine metabolism_Homo sapiens_hsa002300.48584257
118African trypanosomiasis_Homo sapiens_hsa051430.47899276
119Endometrial cancer_Homo sapiens_hsa052130.47828752
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47784154
121Wnt signaling pathway_Homo sapiens_hsa043100.47247365
122Non-small cell lung cancer_Homo sapiens_hsa052230.46973393
123Fatty acid biosynthesis_Homo sapiens_hsa000610.46902132
124Renal cell carcinoma_Homo sapiens_hsa052110.46780957
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46414903
126Arginine and proline metabolism_Homo sapiens_hsa003300.45781141
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45331563
128Inositol phosphate metabolism_Homo sapiens_hsa005620.45191138
129Prion diseases_Homo sapiens_hsa050200.43163224
130Alzheimers disease_Homo sapiens_hsa050100.41499925
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41073720
132Type I diabetes mellitus_Homo sapiens_hsa049400.40880483
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40768205
134Bile secretion_Homo sapiens_hsa049760.37575049
135Nitrogen metabolism_Homo sapiens_hsa009100.37497376
136Insulin signaling pathway_Homo sapiens_hsa049100.36263975
137Endocytosis_Homo sapiens_hsa041440.35949790
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35280126
139Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34256207
140Ovarian steroidogenesis_Homo sapiens_hsa049130.32905255
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31647065
142Colorectal cancer_Homo sapiens_hsa052100.31307722
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31143885
144Chemokine signaling pathway_Homo sapiens_hsa040620.27810468
145Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27770954
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26928524
147Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26398113
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24013962

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