GABRG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.55758260
2behavioral response to nicotine (GO:0035095)5.44438794
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.28211482
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.27254685
5neuron cell-cell adhesion (GO:0007158)5.18186596
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.12829054
7regulation of glutamate receptor signaling pathway (GO:1900449)4.89103465
8ionotropic glutamate receptor signaling pathway (GO:0035235)4.74289298
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.70622375
10synaptic vesicle exocytosis (GO:0016079)4.56877699
11protein localization to synapse (GO:0035418)4.54362769
12locomotory exploration behavior (GO:0035641)4.47111067
13negative regulation of synaptic transmission, GABAergic (GO:0032229)4.45759006
14presynaptic membrane assembly (GO:0097105)4.33603368
15glutamate receptor signaling pathway (GO:0007215)4.32267432
16neurotransmitter-gated ion channel clustering (GO:0072578)4.29396797
17regulation of synaptic vesicle exocytosis (GO:2000300)4.27960021
18synaptic transmission, glutamatergic (GO:0035249)4.18820106
19synaptic vesicle maturation (GO:0016188)4.17812297
20neuron-neuron synaptic transmission (GO:0007270)4.14424473
21postsynaptic membrane organization (GO:0001941)4.07551750
22glutamate secretion (GO:0014047)4.04721251
23neuronal action potential propagation (GO:0019227)4.04549883
24pyrimidine nucleobase catabolic process (GO:0006208)4.03402103
25presynaptic membrane organization (GO:0097090)4.03241073
26positive regulation of synaptic transmission, GABAergic (GO:0032230)4.00812549
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.98087567
28neurotransmitter secretion (GO:0007269)3.96771929
29gamma-aminobutyric acid transport (GO:0015812)3.94695225
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.90632037
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.89287459
32regulation of synaptic vesicle transport (GO:1902803)3.83084378
33startle response (GO:0001964)3.80215684
34response to histamine (GO:0034776)3.75855591
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.73783291
36regulation of neuronal synaptic plasticity (GO:0048168)3.70831644
37exploration behavior (GO:0035640)3.70266285
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.69549710
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64742213
40transmission of nerve impulse (GO:0019226)3.63093713
41L-fucose catabolic process (GO:0042355)3.62367814
42fucose catabolic process (GO:0019317)3.62367814
43L-fucose metabolic process (GO:0042354)3.62367814
44long-term memory (GO:0007616)3.60257707
45* gamma-aminobutyric acid signaling pathway (GO:0007214)3.60163882
46serotonin metabolic process (GO:0042428)3.59949823
47regulation of synaptic transmission, GABAergic (GO:0032228)3.59675245
48regulation of synaptic transmission, glutamatergic (GO:0051966)3.58145488
49positive regulation of membrane potential (GO:0045838)3.57700889
50neuron recognition (GO:0008038)3.56569629
51auditory behavior (GO:0031223)3.55137318
52nucleobase catabolic process (GO:0046113)3.53502926
53response to auditory stimulus (GO:0010996)3.53432637
54primary amino compound metabolic process (GO:1901160)3.53027607
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.52556582
56regulation of postsynaptic membrane potential (GO:0060078)3.52343275
57dendritic spine morphogenesis (GO:0060997)3.48947279
58neuronal action potential (GO:0019228)3.47762189
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.42370493
60neurotransmitter transport (GO:0006836)3.41831828
61long-term synaptic potentiation (GO:0060291)3.41257888
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.37372923
63regulation of glutamate secretion (GO:0014048)3.36477236
64proline transport (GO:0015824)3.34893517
65regulation of synapse structural plasticity (GO:0051823)3.31264129
66axonal fasciculation (GO:0007413)3.23465706
67regulation of neurotransmitter secretion (GO:0046928)3.23440459
68detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.21721108
69behavioral defense response (GO:0002209)3.20436882
70behavioral fear response (GO:0001662)3.20436882
71learning (GO:0007612)3.18396950
72regulation of female receptivity (GO:0045924)3.18044423
73female mating behavior (GO:0060180)3.17645363
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.17622559
75synapse assembly (GO:0007416)3.15806321
76regulation of synaptic plasticity (GO:0048167)3.15225416
77layer formation in cerebral cortex (GO:0021819)3.13078936
78nonmotile primary cilium assembly (GO:0035058)3.11900914
79mechanosensory behavior (GO:0007638)3.11637723
80righting reflex (GO:0060013)3.10173338
81positive regulation of neurotransmitter transport (GO:0051590)3.09807193
82neuronal ion channel clustering (GO:0045161)3.09423074
83membrane hyperpolarization (GO:0060081)3.09141722
84synaptic vesicle endocytosis (GO:0048488)3.08585252
85prepulse inhibition (GO:0060134)3.07957085
86positive regulation of neurotransmitter secretion (GO:0001956)3.06771513
87regulation of neurotransmitter transport (GO:0051588)3.05795490
88positive regulation of synapse assembly (GO:0051965)3.05715878
89striatum development (GO:0021756)3.05682016
90regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03429004
91regulation of neurotransmitter levels (GO:0001505)3.02684397
92membrane depolarization (GO:0051899)3.02335377
93behavioral response to cocaine (GO:0048148)3.00135253
94detection of light stimulus involved in visual perception (GO:0050908)3.00098310
95detection of light stimulus involved in sensory perception (GO:0050962)3.00098310
96negative regulation of amino acid transport (GO:0051956)2.98820464
97regulation of vesicle fusion (GO:0031338)2.97494097
98regulation of dendritic spine morphogenesis (GO:0061001)2.97140327
99retinal cone cell development (GO:0046549)2.96322933
100regulation of synapse maturation (GO:0090128)2.95092518
101positive regulation of synaptic transmission (GO:0050806)2.94538027
102adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.92612461
103fear response (GO:0042596)2.91408706
104* synaptic transmission (GO:0007268)2.90698031
105regulation of synaptic transmission (GO:0050804)2.84052845
106glycine transport (GO:0015816)2.83692528
107neuromuscular process controlling posture (GO:0050884)2.83588966
108epithelial cilium movement (GO:0003351)2.81623285
109indole-containing compound metabolic process (GO:0042430)2.81315275
110intraspecies interaction between organisms (GO:0051703)2.79921321
111social behavior (GO:0035176)2.79921321
112serotonin receptor signaling pathway (GO:0007210)2.79149808
113C4-dicarboxylate transport (GO:0015740)2.78270920
114opioid receptor signaling pathway (GO:0038003)2.78070924
115neuromuscular synaptic transmission (GO:0007274)2.77871792
116protein polyglutamylation (GO:0018095)2.77661582
117membrane depolarization during action potential (GO:0086010)2.77525188
118cerebellar Purkinje cell differentiation (GO:0021702)2.77514824
119negative regulation of dendrite development (GO:2000171)2.77303786
120negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77231664
121regulation of action potential (GO:0098900)2.75415705
122adult walking behavior (GO:0007628)2.74094790
123regulation of neurotransmitter uptake (GO:0051580)2.73857371
124regulation of cilium movement (GO:0003352)2.72583339
125axon ensheathment in central nervous system (GO:0032291)2.72291379
126central nervous system myelination (GO:0022010)2.72291379
127adaptation of signaling pathway (GO:0023058)2.72280934
128piRNA metabolic process (GO:0034587)2.71214185
129behavioral response to ethanol (GO:0048149)2.70842074
130action potential (GO:0001508)2.67052490
131protein localization to cilium (GO:0061512)2.66233775
132photoreceptor cell maintenance (GO:0045494)2.63860395
133regulation of calcium ion-dependent exocytosis (GO:0017158)2.63113820
134synaptic transmission, cholinergic (GO:0007271)2.62326469
135indolalkylamine metabolic process (GO:0006586)2.61190569
136short-term memory (GO:0007614)2.58216094
137cellular ketone body metabolic process (GO:0046950)2.57853561
138response to pheromone (GO:0019236)2.54960988
139water-soluble vitamin biosynthetic process (GO:0042364)2.54718429
140calcium ion-dependent exocytosis (GO:0017156)2.49396046
141regulation of microtubule-based movement (GO:0060632)2.49290482
142reflex (GO:0060004)2.49153427
143positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.48198233
144DNA methylation involved in gamete generation (GO:0043046)2.47241602
145platelet dense granule organization (GO:0060155)2.47182385
146phosphorelay signal transduction system (GO:0000160)2.46154196
147detection of mechanical stimulus involved in sensory perception (GO:0050974)2.45193481
148adult behavior (GO:0030534)2.44564033
149positive regulation of sodium ion transmembrane transport (GO:1902307)2.42751149
150negative regulation of telomere maintenance (GO:0032205)2.42404754
151cochlea development (GO:0090102)2.41020557
152response to amphetamine (GO:0001975)2.40954268
153positive regulation of potassium ion transmembrane transport (GO:1901381)2.38834923

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.53947822
2GBX2_23144817_ChIP-Seq_PC3_Human4.16637412
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00322184
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96865525
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84903483
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57908488
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.55766115
8* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50312860
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49865290
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48826110
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48826110
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.40894709
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37001818
14REST_21632747_ChIP-Seq_MESCs_Mouse2.29511531
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23606947
16TAF15_26573619_Chip-Seq_HEK293_Human2.23229695
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20921474
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20172648
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19916432
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18827366
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.05871700
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05070671
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.04321441
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02701156
25AR_21572438_ChIP-Seq_LNCaP_Human1.98852018
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96451844
27DROSHA_22980978_ChIP-Seq_HELA_Human1.93997871
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87506578
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85071718
30* P300_19829295_ChIP-Seq_ESCs_Human1.83650959
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81671689
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80373251
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.79962324
34IGF1R_20145208_ChIP-Seq_DFB_Human1.79526119
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.79385822
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.77930818
37EWS_26573619_Chip-Seq_HEK293_Human1.77487537
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77017785
39* RARB_27405468_Chip-Seq_BRAIN_Mouse1.72691786
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.72374784
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69411761
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69156089
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59813605
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57314802
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55011901
46RNF2_27304074_Chip-Seq_NSC_Mouse1.52219573
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.48488990
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47284837
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45139208
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.44786154
51FUS_26573619_Chip-Seq_HEK293_Human1.43713031
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.42150770
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38616098
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37763093
55* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37210612
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35336852
57CBP_20019798_ChIP-Seq_JUKART_Human1.35336852
58AR_25329375_ChIP-Seq_VCAP_Human1.34879408
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34234885
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31896987
61* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30561757
62STAT3_23295773_ChIP-Seq_U87_Human1.30011720
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.29881335
64* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29678440
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29199566
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28920665
67BCAT_22108803_ChIP-Seq_LS180_Human1.28090846
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28006061
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.27706377
70ER_23166858_ChIP-Seq_MCF-7_Human1.27658807
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26396245
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25580046
73* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24588282
74TP53_22573176_ChIP-Seq_HFKS_Human1.24423147
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.23663608
76* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21344063
77* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20999973
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.20315932
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19490471
80* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18619375
81* TCF4_23295773_ChIP-Seq_U87_Human1.17695478
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17050091
83* RUNX2_22187159_ChIP-Seq_PCA_Human1.16680216
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15218964
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14859963
86TCF4_22108803_ChIP-Seq_LS180_Human1.14198312
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13826587
88VDR_22108803_ChIP-Seq_LS180_Human1.13175103
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13160597
90P53_22387025_ChIP-Seq_ESCs_Mouse1.12720620
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.10905791
92NANOG_19829295_ChIP-Seq_ESCs_Human1.10273955
93SOX2_19829295_ChIP-Seq_ESCs_Human1.10273955
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.10165602
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10018598
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09824143
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.09813209
98* SMAD4_21741376_ChIP-Seq_EPCs_Human1.09584314
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.09193612
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08540864
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07939132
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07005200
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07005200
104IRF1_19129219_ChIP-ChIP_H3396_Human1.06996825
105* JUN_21703547_ChIP-Seq_K562_Human1.06871380
106ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06449087
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06398483
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.06200606
109TP53_18474530_ChIP-ChIP_U2OS_Human1.06001120
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05637713
111AR_19668381_ChIP-Seq_PC3_Human1.05352844
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04970416
113AHR_22903824_ChIP-Seq_MCF-7_Human1.03796534
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02957842
115TAL1_26923725_Chip-Seq_HPCs_Mouse1.01961323
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01689852
117NCOR_22424771_ChIP-Seq_293T_Human1.01315802
118ZNF274_21170338_ChIP-Seq_K562_Hela1.01215055
119NFE2_27457419_Chip-Seq_LIVER_Mouse1.00693164
120ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00604890
121YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00373471
122ERG_21242973_ChIP-ChIP_JURKAT_Human1.00147437
123STAT3_18555785_Chip-Seq_ESCs_Mouse0.99892673
124KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99409241
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98827797
126SOX2_18555785_Chip-Seq_ESCs_Mouse0.97698978
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97214792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.25122066
2MP0003880_abnormal_central_pattern4.67861743
3MP0003635_abnormal_synaptic_transmissio3.77106211
4MP0009745_abnormal_behavioral_response3.52493604
5MP0009046_muscle_twitch3.42995007
6MP0001968_abnormal_touch/_nociception3.12578322
7MP0002063_abnormal_learning/memory/cond3.12418851
8MP0002064_seizures3.07810763
9MP0002822_catalepsy3.04565699
10MP0005423_abnormal_somatic_nervous2.98740946
11MP0002572_abnormal_emotion/affect_behav2.90996414
12MP0001486_abnormal_startle_reflex2.86576740
13MP0004270_analgesia2.77092021
14MP0008877_abnormal_DNA_methylation2.71999524
15MP0005645_abnormal_hypothalamus_physiol2.60611438
16MP0002272_abnormal_nervous_system2.57062157
17MP0002736_abnormal_nociception_after2.47930552
18MP0001501_abnormal_sleep_pattern2.44938575
19MP0001188_hyperpigmentation2.41926333
20MP0002734_abnormal_mechanical_nocicepti2.37555347
21MP0005646_abnormal_pituitary_gland2.32324076
22MP0006276_abnormal_autonomic_nervous2.32044787
23MP0002735_abnormal_chemical_nociception2.30125691
24MP0001440_abnormal_grooming_behavior2.12560510
25MP0004147_increased_porphyrin_level2.07042919
26MP0002067_abnormal_sensory_capabilities1.99360711
27MP0001984_abnormal_olfaction1.96030323
28MP0002557_abnormal_social/conspecific_i1.93286859
29MP0003787_abnormal_imprinting1.91019785
30MP0002733_abnormal_thermal_nociception1.90689478
31MP0001970_abnormal_pain_threshold1.87625615
32MP0003122_maternal_imprinting1.82260855
33MP0005386_behavior/neurological_phenoty1.74735445
34MP0004924_abnormal_behavior1.74735445
35MP0002184_abnormal_innervation1.74733600
36MP0000778_abnormal_nervous_system1.73278633
37MP0001529_abnormal_vocalization1.72955975
38MP0002653_abnormal_ependyma_morphology1.61411487
39MP0004043_abnormal_pH_regulation1.58555622
40MP0003879_abnormal_hair_cell1.54664123
41MP0001502_abnormal_circadian_rhythm1.54134268
42MP0008569_lethality_at_weaning1.53348974
43MP0004142_abnormal_muscle_tone1.51139760
44MP0003195_calcinosis1.43509414
45MP0001905_abnormal_dopamine_level1.41562811
46MP0006292_abnormal_olfactory_placode1.38884365
47MP0004811_abnormal_neuron_physiology1.34627734
48MP0004742_abnormal_vestibular_system1.33109516
49MP0002066_abnormal_motor_capabilities/c1.30092473
50MP0005551_abnormal_eye_electrophysiolog1.30032933
51MP0005409_darkened_coat_color1.28951571
52MP0002876_abnormal_thyroid_physiology1.28154728
53MP0002882_abnormal_neuron_morphology1.27677392
54MP0010386_abnormal_urinary_bladder1.27288826
55MP0001986_abnormal_taste_sensitivity1.24395936
56MP0002837_dystrophic_cardiac_calcinosis1.23093429
57MP0009780_abnormal_chondrocyte_physiolo1.20865560
58MP0002638_abnormal_pupillary_reflex1.20005534
59MP0000955_abnormal_spinal_cord1.18460360
60MP0005171_absent_coat_pigmentation1.16877143
61MP0004885_abnormal_endolymph1.13683316
62MP0004133_heterotaxia1.13174506
63MP0000427_abnormal_hair_cycle1.11368935
64MP0003011_delayed_dark_adaptation1.09093498
65MP0008789_abnormal_olfactory_epithelium1.09007969
66MP0002909_abnormal_adrenal_gland1.07966571
67MP0001963_abnormal_hearing_physiology1.06369933
68MP0003646_muscle_fatigue1.05081447
69MP0003633_abnormal_nervous_system1.05030607
70MP0000631_abnormal_neuroendocrine_gland0.99837688
71MP0008875_abnormal_xenobiotic_pharmacok0.97163496
72MP0002234_abnormal_pharynx_morphology0.96908843
73MP0004858_abnormal_nervous_system0.93994358
74MP0003119_abnormal_digestive_system0.92501092
75MP0002152_abnormal_brain_morphology0.91596651
76MP0002938_white_spotting0.91416201
77MP0003136_yellow_coat_color0.91222960
78MP0002102_abnormal_ear_morphology0.91078445
79MP0005187_abnormal_penis_morphology0.90735948
80MP0003878_abnormal_ear_physiology0.90684988
81MP0005377_hearing/vestibular/ear_phenot0.90684988
82MP0005195_abnormal_posterior_eye0.90384367
83MP0008995_early_reproductive_senescence0.90243758
84MP0002160_abnormal_reproductive_system0.90210832
85MP0002069_abnormal_eating/drinking_beha0.89544276
86MP0001177_atelectasis0.89143679
87MP0005410_abnormal_fertilization0.88837831
88MP0003631_nervous_system_phenotype0.88208601
89MP0000569_abnormal_digit_pigmentation0.87060685
90MP0002752_abnormal_somatic_nervous0.86115260
91MP0002229_neurodegeneration0.85863832
92MP0008872_abnormal_physiological_respon0.83394881
93MP0000026_abnormal_inner_ear0.82839532
94MP0005167_abnormal_blood-brain_barrier0.82534849
95MP0003698_abnormal_male_reproductive0.81187950
96MP0003121_genomic_imprinting0.80257145
97MP0002751_abnormal_autonomic_nervous0.77904709
98MP0005394_taste/olfaction_phenotype0.77487266
99MP0005499_abnormal_olfactory_system0.77487266
100MP0005174_abnormal_tail_pigmentation0.77132721
101MP0004085_abnormal_heartbeat0.76020935
102MP0001485_abnormal_pinna_reflex0.75329384
103MP0003690_abnormal_glial_cell0.74375850
104MP0008874_decreased_physiological_sensi0.71710363
105MP0000015_abnormal_ear_pigmentation0.70928481
106MP0005253_abnormal_eye_physiology0.70537706
107MP0005535_abnormal_body_temperature0.70392715
108MP0005379_endocrine/exocrine_gland_phen0.67771624
109MP0003329_amyloid_beta_deposits0.67081681
110MP0002090_abnormal_vision0.63331847
111MP0001664_abnormal_digestion0.63264140
112MP0002163_abnormal_gland_morphology0.62369210
113MP0003634_abnormal_glial_cell0.62253131
114MP0000566_synostosis0.61395725
115MP0000920_abnormal_myelination0.60978568
116MP0004145_abnormal_muscle_electrophysio0.60252631
117MP0006072_abnormal_retinal_apoptosis0.56960369
118MP0004484_altered_response_of0.54888469
119MP0003137_abnormal_impulse_conducting0.54766931
120MP0000751_myopathy0.54486713
121MP0003632_abnormal_nervous_system0.52571840
122MP0001348_abnormal_lacrimal_gland0.52139646
123MP0000681_abnormal_thyroid_gland0.51457032
124MP0000372_irregular_coat_pigmentation0.47997261
125MP0001943_abnormal_respiration0.47526062
126MP0002277_abnormal_respiratory_mucosa0.44747051

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.54581009
2Febrile seizures (HP:0002373)5.76834780
3Focal seizures (HP:0007359)5.43443135
4Myokymia (HP:0002411)5.26372123
5Epileptic encephalopathy (HP:0200134)5.23775204
6Atonic seizures (HP:0010819)4.92634680
7Absence seizures (HP:0002121)4.22103036
8Hyperventilation (HP:0002883)4.03129689
9Dialeptic seizures (HP:0011146)3.96567198
10Generalized tonic-clonic seizures (HP:0002069)3.95851953
11Broad-based gait (HP:0002136)3.92239594
12Progressive cerebellar ataxia (HP:0002073)3.86912968
13Pancreatic cysts (HP:0001737)3.81714852
14Visual hallucinations (HP:0002367)3.62811342
15Pancreatic fibrosis (HP:0100732)3.53223963
16Abnormality of midbrain morphology (HP:0002418)3.53192870
17Molar tooth sign on MRI (HP:0002419)3.53192870
18True hermaphroditism (HP:0010459)3.37247362
19Congenital stationary night blindness (HP:0007642)3.16465739
20Nephronophthisis (HP:0000090)3.16213774
21Gaze-evoked nystagmus (HP:0000640)3.15375134
22Type II lissencephaly (HP:0007260)3.07425794
23Polyphagia (HP:0002591)3.00039754
24Abnormal eating behavior (HP:0100738)2.98119949
25Poor eye contact (HP:0000817)2.97657510
26Abnormal hair whorl (HP:0010721)2.93246089
27Progressive inability to walk (HP:0002505)2.92747306
28Drooling (HP:0002307)2.83742731
29Excessive salivation (HP:0003781)2.83742731
30Absent speech (HP:0001344)2.81119714
31Dysdiadochokinesis (HP:0002075)2.80906082
32Action tremor (HP:0002345)2.75382004
33Absent/shortened dynein arms (HP:0200106)2.73842837
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.73842837
35Inability to walk (HP:0002540)2.73433240
36Fetal akinesia sequence (HP:0001989)2.70843347
37Protruding tongue (HP:0010808)2.69200989
38Gait imbalance (HP:0002141)2.66561735
39Abnormality of the renal medulla (HP:0100957)2.64257775
40Blue irides (HP:0000635)2.61668188
41Anxiety (HP:0000739)2.58515662
42Hemiparesis (HP:0001269)2.57750961
43Abnormality of the renal cortex (HP:0011035)2.56472538
44Lissencephaly (HP:0001339)2.55459241
45Limb dystonia (HP:0002451)2.52394043
46Impaired social interactions (HP:0000735)2.50929502
47Abnormal social behavior (HP:0012433)2.50929502
48Abnormal ciliary motility (HP:0012262)2.49270947
49Attenuation of retinal blood vessels (HP:0007843)2.47834715
50Medial flaring of the eyebrow (HP:0010747)2.46096868
51Abnormality of the labia minora (HP:0012880)2.44991921
52Truncal ataxia (HP:0002078)2.43605446
53Pendular nystagmus (HP:0012043)2.42793391
54Diplopia (HP:0000651)2.42314338
55Abnormality of binocular vision (HP:0011514)2.42314338
56Ankle clonus (HP:0011448)2.39854175
57Urinary bladder sphincter dysfunction (HP:0002839)2.39095097
58Dysmetria (HP:0001310)2.38590702
59Impaired vibration sensation in the lower limbs (HP:0002166)2.37766289
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.36512540
61Abnormality of alanine metabolism (HP:0010916)2.36512540
62Hyperalaninemia (HP:0003348)2.36512540
63Mutism (HP:0002300)2.36257384
64Cystic liver disease (HP:0006706)2.35407117
65Amblyopia (HP:0000646)2.35143890
66Congenital primary aphakia (HP:0007707)2.34567509
67Abolished electroretinogram (ERG) (HP:0000550)2.33832461
68Optic nerve hypoplasia (HP:0000609)2.32892922
69Depression (HP:0000716)2.29477260
70Epileptiform EEG discharges (HP:0011182)2.29040147
71Large for gestational age (HP:0001520)2.28147643
72Generalized hypopigmentation of hair (HP:0011358)2.27733881
73Nephrogenic diabetes insipidus (HP:0009806)2.26734437
74Fair hair (HP:0002286)2.26456491
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.24009120
76Pachygyria (HP:0001302)2.23177768
77Supranuclear gaze palsy (HP:0000605)2.22326851
78Postural instability (HP:0002172)2.20995423
79Sclerocornea (HP:0000647)2.18958148
80Genetic anticipation (HP:0003743)2.18502060
81Tubular atrophy (HP:0000092)2.17349005
82Abnormality of salivation (HP:0100755)2.11914256
83EEG with generalized epileptiform discharges (HP:0011198)2.11813656
84Poor coordination (HP:0002370)2.07934450
85Abnormal rod and cone electroretinograms (HP:0008323)2.06841771
86Status epilepticus (HP:0002133)2.03582161
87Anencephaly (HP:0002323)2.03307291
88Scanning speech (HP:0002168)2.02787317
89Sleep apnea (HP:0010535)2.02455853
90Esotropia (HP:0000565)2.00960646
91Aplasia/Hypoplasia of the tibia (HP:0005772)2.00585831
92Stereotypic behavior (HP:0000733)2.00176034
93Generalized myoclonic seizures (HP:0002123)2.00085418
94Narrow nasal bridge (HP:0000446)1.99304314
95Polydipsia (HP:0001959)1.97872394
96Abnormal drinking behavior (HP:0030082)1.97872394
97Specific learning disability (HP:0001328)1.97184123
98Abnormal respiratory motile cilium physiology (HP:0012261)1.97078931
99Widely spaced teeth (HP:0000687)1.96560372
100Bradykinesia (HP:0002067)1.96254030
101Hypsarrhythmia (HP:0002521)1.95519049
102Torticollis (HP:0000473)1.93790420
103Poor suck (HP:0002033)1.91528620
104Genital tract atresia (HP:0001827)1.90298561
105Hypothermia (HP:0002045)1.90179958
106Failure to thrive in infancy (HP:0001531)1.89886478
107Agitation (HP:0000713)1.89247026
108Abnormal respiratory epithelium morphology (HP:0012253)1.88894996
109Abnormal respiratory motile cilium morphology (HP:0005938)1.88894996
110Inappropriate behavior (HP:0000719)1.88591070
111Spastic tetraplegia (HP:0002510)1.86860005
112Renal cortical cysts (HP:0000803)1.86715860
113Vaginal atresia (HP:0000148)1.85606626
114Focal dystonia (HP:0004373)1.83753798
115Bony spicule pigmentary retinopathy (HP:0007737)1.82077294
116Cerebellar dysplasia (HP:0007033)1.81866615
117Increased corneal curvature (HP:0100692)1.80500600
118Keratoconus (HP:0000563)1.80500600
119Incomplete penetrance (HP:0003829)1.80382506
120Aplasia/Hypoplasia of the tongue (HP:0010295)1.80227686
121Abnormal EKG (HP:0003115)1.79936566
122Severe muscular hypotonia (HP:0006829)1.79753931
123Colon cancer (HP:0003003)1.79670530
124Acute necrotizing encephalopathy (HP:0006965)1.79469170
125Furrowed tongue (HP:0000221)1.77601049
126Hemiplegia (HP:0002301)1.77100574
127Impaired vibratory sensation (HP:0002495)1.75165832
128Absent eyebrow (HP:0002223)1.74530775
129Postaxial hand polydactyly (HP:0001162)1.73352953
130Morphological abnormality of the pyramidal tract (HP:0002062)1.73224562
1313-Methylglutaconic aciduria (HP:0003535)1.73218673
132Glioma (HP:0009733)1.73139792
133Thyroid-stimulating hormone excess (HP:0002925)1.72620524
134Decreased circulating renin level (HP:0003351)1.71792866
135Papilledema (HP:0001085)1.71570645
136Spastic gait (HP:0002064)1.70555793
137Postaxial foot polydactyly (HP:0001830)1.70510402
138Impaired smooth pursuit (HP:0007772)1.70393851
139Decreased central vision (HP:0007663)1.70235493
140Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69404190
141Degeneration of the lateral corticospinal tracts (HP:0002314)1.69404190
142Stomach cancer (HP:0012126)1.68890835
143Male pseudohermaphroditism (HP:0000037)1.68563929
144Lower limb amyotrophy (HP:0007210)1.68316777
145Exotropia (HP:0000577)1.68291970
146Clumsiness (HP:0002312)1.67424539
147Absent rod-and cone-mediated responses on ERG (HP:0007688)1.67235330
148Chronic hepatic failure (HP:0100626)1.65847797
149Lower limb muscle weakness (HP:0007340)1.64460935
150Aplasia involving bones of the upper limbs (HP:0009823)1.63962244
151Aplasia of the phalanges of the hand (HP:0009802)1.63962244
152Aplasia involving bones of the extremities (HP:0009825)1.63962244
153Deeply set eye (HP:0000490)1.63343421
154Akinesia (HP:0002304)1.60961326
155Retinal dysplasia (HP:0007973)1.60562633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.52089633
2EPHA44.05774281
3FRK4.02340556
4CASK3.93358832
5MAP2K73.27509413
6MAP3K123.04970090
7MARK12.94507472
8MAP4K22.83207055
9MAP3K42.76905305
10TNIK2.67252177
11MAP3K92.53951594
12NTRK22.33242991
13MINK12.06708650
14GRK12.03530051
15RIPK42.03011997
16WNK41.99887634
17ACVR1B1.90634862
18NUAK11.88053432
19MAPK131.83647347
20PRPF4B1.76078589
21ZAK1.71572659
22TAOK31.69937013
23SIK31.65287456
24MAP2K41.62511901
25DAPK21.62191208
26PLK21.53892400
27AKT31.51650843
28BMPR21.47652915
29SIK21.44819210
30STK391.40570131
31CSNK1G31.37507091
32FES1.37244012
33CDK51.32015581
34SGK21.31306983
35DAPK11.28238972
36PAK61.27639425
37DYRK21.27210784
38CSNK1A1L1.26632374
39TLK11.20503288
40ADRBK21.19173363
41CSNK1G11.19166869
42PRKCG1.18238550
43SGK4941.17560503
44SGK2231.17560503
45CAMK2A1.16907885
46MUSK1.14539238
47ARAF1.13128047
48MAP3K131.12343540
49KSR11.10106668
50NEK61.07108377
51GRK51.06951291
52TNK21.04933012
53NTRK10.99459870
54CAMKK10.96497738
55GRK70.96372877
56STK380.94872955
57TRIM280.93283229
58PRKCE0.91801194
59WNK30.89057797
60PIK3CA0.86510718
61SGK10.86380914
62CAMK2B0.84413221
63EPHA30.82969680
64OXSR10.80722544
65SGK30.80539211
66PRKD30.79691749
67CDK190.79649020
68CAMKK20.78315213
69BMPR1B0.76626542
70PNCK0.74480412
71PHKG20.73863875
72PHKG10.73863875
73INSRR0.72884893
74KSR20.72573456
75CAMK1D0.72012586
76UHMK10.71979398
77CAMK10.70324683
78CCNB10.66622624
79CDK30.64475554
80ERBB30.63985708
81CAMK1G0.63661120
82MAPKAPK50.62078645
83PRKCH0.61657654
84DYRK1A0.61411339
85PINK10.61019465
86PKN10.59978331
87BRAF0.58170654
88BCR0.56884874
89BCKDK0.55338204
90NEK20.53972885
91YES10.53650368
92CDK180.53562381
93CAMK2D0.53412156
94STK110.53129471
95MAPK150.53099107
96MKNK20.52319726
97MAP2K60.48817928
98LATS20.48714833
99NME10.48575841
100CDK150.47428227
101CSNK1D0.47276931
102CSNK1A10.46765147
103CDK140.45859547
104MAPK70.45357229
105MAP3K10.44970972
106ADRBK10.44499264
107PRKCZ0.43897701
108STK38L0.43827409
109PRKAA10.43353905
110CAMK2G0.43156407
111PLK30.43138948
112MARK20.42681356
113TXK0.41190862
114PRKACA0.40801576
115CSNK1G20.40407932
116PRKG10.40200299
117RPS6KA30.39991579
118MAP3K60.39821655
119PTK2B0.39569090
120CDK11A0.39059698
121MAPK120.38594836
122CDC42BPA0.37808824
123PAK30.36372737
124FER0.35545046
125ERBB40.35453913
126CSNK1E0.35402938
127PRKCA0.35402705
128RPS6KA50.35258871
129VRK10.35085248
130PRKCB0.34695666
131TGFBR10.34523320
132RPS6KA20.33829039
133CDK80.33480550
134MAPK100.33463213
135LIMK10.32486659
136PLK40.32033142
137ERBB20.30941718
138PRKCQ0.30654431
139CAMK40.27173179

Predicted pathways (KEGG)

RankGene SetZ-score
1* Nicotine addiction_Homo sapiens_hsa050334.42875048
2Synaptic vesicle cycle_Homo sapiens_hsa047213.27636066
3* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.92064609
4* GABAergic synapse_Homo sapiens_hsa047272.91366945
5Olfactory transduction_Homo sapiens_hsa047402.84133148
6* Morphine addiction_Homo sapiens_hsa050322.83007178
7Circadian entrainment_Homo sapiens_hsa047132.62588663
8Glutamatergic synapse_Homo sapiens_hsa047242.60754101
9Long-term potentiation_Homo sapiens_hsa047202.28207505
10Amphetamine addiction_Homo sapiens_hsa050312.25812301
11Serotonergic synapse_Homo sapiens_hsa047262.13210837
12Taste transduction_Homo sapiens_hsa047422.12040727
13Butanoate metabolism_Homo sapiens_hsa006502.08171908
14Collecting duct acid secretion_Homo sapiens_hsa049662.04474362
15Salivary secretion_Homo sapiens_hsa049702.01226883
16Dopaminergic synapse_Homo sapiens_hsa047281.98882785
17Nitrogen metabolism_Homo sapiens_hsa009101.90972854
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90651231
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88603503
20* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.84402393
21Insulin secretion_Homo sapiens_hsa049111.82287359
22Cholinergic synapse_Homo sapiens_hsa047251.81146394
23Cocaine addiction_Homo sapiens_hsa050301.73317950
24Calcium signaling pathway_Homo sapiens_hsa040201.72235451
25Renin secretion_Homo sapiens_hsa049241.72183688
26Linoleic acid metabolism_Homo sapiens_hsa005911.72081626
27Phototransduction_Homo sapiens_hsa047441.68970335
28Long-term depression_Homo sapiens_hsa047301.68934553
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65102637
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64096231
31Selenocompound metabolism_Homo sapiens_hsa004501.63997156
32Gastric acid secretion_Homo sapiens_hsa049711.55399099
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48477573
34Oxytocin signaling pathway_Homo sapiens_hsa049211.45770806
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40897912
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39614413
37Type I diabetes mellitus_Homo sapiens_hsa049401.34054216
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28928215
39Basal transcription factors_Homo sapiens_hsa030221.27286479
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26609563
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.23206571
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22345861
43cAMP signaling pathway_Homo sapiens_hsa040241.19742700
44Axon guidance_Homo sapiens_hsa043601.18136304
45Gap junction_Homo sapiens_hsa045401.16999899
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14174233
47Tryptophan metabolism_Homo sapiens_hsa003801.14080524
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13682907
49GnRH signaling pathway_Homo sapiens_hsa049121.13086428
50Vibrio cholerae infection_Homo sapiens_hsa051101.07350430
51Propanoate metabolism_Homo sapiens_hsa006401.04427795
52Cardiac muscle contraction_Homo sapiens_hsa042601.01131413
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99894897
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98481047
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97823669
56Protein export_Homo sapiens_hsa030600.96937910
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95183598
58Type II diabetes mellitus_Homo sapiens_hsa049300.94797349
59Oxidative phosphorylation_Homo sapiens_hsa001900.94309408
60Rheumatoid arthritis_Homo sapiens_hsa053230.93829317
61Peroxisome_Homo sapiens_hsa041460.92735993
62ErbB signaling pathway_Homo sapiens_hsa040120.92509876
63Melanogenesis_Homo sapiens_hsa049160.92162765
64Fanconi anemia pathway_Homo sapiens_hsa034600.89068456
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87958667
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.87767219
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86805997
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84120134
69ABC transporters_Homo sapiens_hsa020100.79578837
70Estrogen signaling pathway_Homo sapiens_hsa049150.79306095
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76870339
72African trypanosomiasis_Homo sapiens_hsa051430.76278711
73Alzheimers disease_Homo sapiens_hsa050100.75078035
74RNA degradation_Homo sapiens_hsa030180.74583825
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73215720
76MAPK signaling pathway_Homo sapiens_hsa040100.70950872
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70654716
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.69617564
79Caffeine metabolism_Homo sapiens_hsa002320.68558558
80Glioma_Homo sapiens_hsa052140.67137148
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.66074358
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.65858589
83Dilated cardiomyopathy_Homo sapiens_hsa054140.64231612
84Ovarian steroidogenesis_Homo sapiens_hsa049130.63561258
85Ras signaling pathway_Homo sapiens_hsa040140.63510112
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61898661
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61703406
88Fatty acid biosynthesis_Homo sapiens_hsa000610.61205685
89Parkinsons disease_Homo sapiens_hsa050120.60903285
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60641437
91beta-Alanine metabolism_Homo sapiens_hsa004100.60127280
92Dorso-ventral axis formation_Homo sapiens_hsa043200.59822938
93Pancreatic secretion_Homo sapiens_hsa049720.58723202
94Choline metabolism in cancer_Homo sapiens_hsa052310.58198073
95Retinol metabolism_Homo sapiens_hsa008300.57883032
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57204535
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56828599
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56625648
99Homologous recombination_Homo sapiens_hsa034400.54541570
100RNA polymerase_Homo sapiens_hsa030200.53053121
101Chemical carcinogenesis_Homo sapiens_hsa052040.51966327
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51650287
103Bile secretion_Homo sapiens_hsa049760.49800273
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48710428
105Steroid biosynthesis_Homo sapiens_hsa001000.46904321
106Arachidonic acid metabolism_Homo sapiens_hsa005900.46208089
107Huntingtons disease_Homo sapiens_hsa050160.44892643
108Alcoholism_Homo sapiens_hsa050340.44752692
109Rap1 signaling pathway_Homo sapiens_hsa040150.44690980
110Thyroid hormone synthesis_Homo sapiens_hsa049180.43886440
111Histidine metabolism_Homo sapiens_hsa003400.42291644
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42281867
113Chemokine signaling pathway_Homo sapiens_hsa040620.42277505
114Circadian rhythm_Homo sapiens_hsa047100.42276483
115Wnt signaling pathway_Homo sapiens_hsa043100.42120049
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41582950
117Glycerolipid metabolism_Homo sapiens_hsa005610.41279183
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.41278538
119Inositol phosphate metabolism_Homo sapiens_hsa005620.40892436
120Phagosome_Homo sapiens_hsa041450.39841664
121Metabolic pathways_Homo sapiens_hsa011000.39436670
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38198553
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37932555
124Oocyte meiosis_Homo sapiens_hsa041140.37599929
125Graft-versus-host disease_Homo sapiens_hsa053320.36499432
126Sulfur relay system_Homo sapiens_hsa041220.36395564
127Arginine and proline metabolism_Homo sapiens_hsa003300.36239421
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36176774
129Ether lipid metabolism_Homo sapiens_hsa005650.32703625
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.32324173
131Melanoma_Homo sapiens_hsa052180.30672006
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30060090
133Autoimmune thyroid disease_Homo sapiens_hsa053200.29995523
134Prion diseases_Homo sapiens_hsa050200.28256347
135Mineral absorption_Homo sapiens_hsa049780.25645020
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24508749
137Sphingolipid metabolism_Homo sapiens_hsa006000.24265748
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23000009
139Glucagon signaling pathway_Homo sapiens_hsa049220.21674785
140Regulation of autophagy_Homo sapiens_hsa041400.20105572
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19381837

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