GABRP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma secretion (GO:0072643)7.11795903
2neutrophil activation involved in immune response (GO:0002283)6.87207600
3galactose catabolic process (GO:0019388)6.83078506
4keratinocyte development (GO:0003334)6.59546358
5surfactant homeostasis (GO:0043129)6.25674427
6hemidesmosome assembly (GO:0031581)6.15935943
7establishment of apical/basal cell polarity (GO:0035089)6.09032180
8negative regulation of keratinocyte proliferation (GO:0010839)6.04426530
9positive regulation of glycoprotein biosynthetic process (GO:0010560)5.31874751
10establishment or maintenance of monopolar cell polarity (GO:0061339)5.16752483
11establishment of monopolar cell polarity (GO:0061162)5.16752483
12positive regulation of SMAD protein import into nucleus (GO:0060391)5.00202961
13negative regulation of homotypic cell-cell adhesion (GO:0034111)4.92892894
14positive regulation of glycoprotein metabolic process (GO:1903020)4.89700530
15keratinocyte proliferation (GO:0043616)4.79727857
16chemical homeostasis within a tissue (GO:0048875)4.78118076
17gap junction assembly (GO:0016264)4.76625323
18hypotonic response (GO:0006971)4.71760018
19glial cell proliferation (GO:0014009)4.67585139
20hepatocyte apoptotic process (GO:0097284)4.60550445
21transepithelial transport (GO:0070633)4.59522557
22cornea development in camera-type eye (GO:0061303)4.55595127
23one-carbon compound transport (GO:0019755)4.53542273
24mesodermal cell differentiation (GO:0048333)4.52143233
25diterpenoid biosynthetic process (GO:0016102)4.48668836
26desmosome organization (GO:0002934)4.39890599
27regulation of hippo signaling (GO:0035330)4.36932379
28nephron tubule formation (GO:0072079)4.36842274
29retinal metabolic process (GO:0042574)4.33905667
30mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.33720739
31lung lobe morphogenesis (GO:0060463)4.27860502
32galactose metabolic process (GO:0006012)4.27792072
33epithelial cell differentiation involved in prostate gland development (GO:0060742)4.19409872
34keratan sulfate catabolic process (GO:0042340)4.06483863
35positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003604.04733189
36bundle of His cell to Purkinje myocyte communication (GO:0086069)4.02626146
37lens morphogenesis in camera-type eye (GO:0002089)4.00858418
38terpenoid biosynthetic process (GO:0016114)4.00551854
39regulation of hair follicle development (GO:0051797)3.99562073
40regulation of glomerular filtration (GO:0003093)3.93941501
41cell adhesion mediated by integrin (GO:0033627)3.93842186
42regulation of keratinocyte proliferation (GO:0010837)3.91523269
43gas transport (GO:0015669)3.89958024
44regulation of SMAD protein import into nucleus (GO:0060390)3.86864156
45lung-associated mesenchyme development (GO:0060484)3.86278808
46positive regulation of osteoblast proliferation (GO:0033690)3.84118630
47ear development (GO:0043583)3.81419629
48regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.80039759
49epithelial cell-cell adhesion (GO:0090136)3.77249697
50embryonic cranial skeleton morphogenesis (GO:0048701)3.76637602
51L-ascorbic acid metabolic process (GO:0019852)3.75696652
52glomerular epithelial cell development (GO:0072310)3.70667989
53regulation of podosome assembly (GO:0071801)3.63262404
54glomerular visceral epithelial cell development (GO:0072015)3.60432362
55negative regulation of activin receptor signaling pathway (GO:0032926)3.59271689
56regulation of cardioblast differentiation (GO:0051890)3.57612286
57protein autoprocessing (GO:0016540)3.54673957
58gastrulation with mouth forming second (GO:0001702)3.53889211
59embryonic foregut morphogenesis (GO:0048617)3.50059590
60embryonic process involved in female pregnancy (GO:0060136)3.48707366
61establishment of tissue polarity (GO:0007164)3.48608301
62establishment of planar polarity (GO:0001736)3.48608301
63hepatocyte differentiation (GO:0070365)3.46313831
64regulation of posttranscriptional gene silencing (GO:0060147)3.43935314
65regulation of gene silencing by miRNA (GO:0060964)3.43935314
66regulation of gene silencing by RNA (GO:0060966)3.43935314
67neuron remodeling (GO:0016322)3.43334481
68renal system process involved in regulation of blood volume (GO:0001977)3.41604437
69polarized epithelial cell differentiation (GO:0030859)3.41074664
70embryonic camera-type eye development (GO:0031076)3.40320389
71negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.40016284
72negative regulation of chondrocyte differentiation (GO:0032331)3.38616588
73cytoskeletal anchoring at plasma membrane (GO:0007016)3.37135765
74hippo signaling (GO:0035329)3.36875031
75vitamin transmembrane transport (GO:0035461)3.32836603
76genitalia morphogenesis (GO:0035112)3.32432009
77female gonad development (GO:0008585)3.28469106
78positive regulation of endothelial cell differentiation (GO:0045603)3.28052562
79respiratory tube development (GO:0030323)3.27271501
80intestinal epithelial cell development (GO:0060576)3.26575938
81regulation of protein homooligomerization (GO:0032462)3.26540504
82ruffle organization (GO:0031529)3.24796983
83positive regulation of hair cycle (GO:0042635)3.23525097
84positive regulation of hair follicle development (GO:0051798)3.23525097
85organ formation (GO:0048645)3.23276297
86regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.23189869
87morphogenesis of an epithelial fold (GO:0060571)3.21840722
88negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.20883024
89epithelial tube formation (GO:0072175)3.20631394
90lung epithelium development (GO:0060428)3.19303439
91regulation of interleukin-8 secretion (GO:2000482)3.18149571
92regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.17941735
93adhesion of symbiont to host cell (GO:0044650)3.15003630
94virion attachment to host cell (GO:0019062)3.15003630
95negative regulation of platelet activation (GO:0010544)3.13342061
96positive regulation of odontogenesis (GO:0042482)3.10949420
97retinol metabolic process (GO:0042572)3.10511817
98embryonic skeletal joint morphogenesis (GO:0060272)3.10065426
99anatomical structure regression (GO:0060033)3.09047100
100regulation of platelet aggregation (GO:0090330)3.09034252
101protein localization to endosome (GO:0036010)3.08474259
102hair follicle morphogenesis (GO:0031069)3.07612530
103epithelial tube branching involved in lung morphogenesis (GO:0060441)3.05807546
104negative regulation of protein oligomerization (GO:0032460)3.05580947
105establishment or maintenance of bipolar cell polarity (GO:0061245)3.04931310
106establishment or maintenance of apical/basal cell polarity (GO:0035088)3.04931310
107multicellular organismal water homeostasis (GO:0050891)3.03776327
108positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.02986057
109skin morphogenesis (GO:0043589)3.02822106
110endothelial tube morphogenesis (GO:0061154)3.02551109
111morphogenesis of an endothelium (GO:0003159)3.02551109
112ectoderm development (GO:0007398)3.02095488
113L-serine metabolic process (GO:0006563)3.01909066
114calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.01560886
115regulation of transforming growth factor beta2 production (GO:0032909)3.00228444
116negative regulation of cell fate specification (GO:0009996)2.99881066
117regulation of sulfur metabolic process (GO:0042762)2.99248153
118renal filtration (GO:0097205)2.98908110
119branching involved in salivary gland morphogenesis (GO:0060445)2.98446372
120regulation of vasculogenesis (GO:2001212)2.97186921
121embryonic epithelial tube formation (GO:0001838)2.96855465
122dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.96448382
123regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.96076612
124tight junction assembly (GO:0070830)2.95005991
125morphogenesis of embryonic epithelium (GO:0016331)2.94693022
126keratinocyte differentiation (GO:0030216)2.94268095
127regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.94040245
128axis elongation (GO:0003401)2.92560650
129glutathione derivative metabolic process (GO:1901685)2.92276937
130glutathione derivative biosynthetic process (GO:1901687)2.92276937
131regulation of glomerulus development (GO:0090192)2.91795645
132response to xenobiotic stimulus (GO:0009410)2.91534871
133positive regulation of toll-like receptor signaling pathway (GO:0034123)2.90010581
134positive regulation of catenin import into nucleus (GO:0035413)2.87319233
135branch elongation of an epithelium (GO:0060602)2.86089278
136regulation of smooth muscle cell differentiation (GO:0051150)2.85796483
137negative regulation of organ growth (GO:0046621)2.85155106
138gland morphogenesis (GO:0022612)2.85125356
139proline biosynthetic process (GO:0006561)2.83776959
140mesenchymal cell proliferation (GO:0010463)2.83573344
141mesenchymal cell differentiation involved in renal system development (GO:2001012)2.82777873
142mesenchymal cell differentiation involved in kidney development (GO:0072161)2.82777873
143mesenchymal to epithelial transition (GO:0060231)2.82191564
144face development (GO:0060324)2.81935895
145regulation of endothelial cell differentiation (GO:0045601)2.81768621
146detection of other organism (GO:0098543)2.81706477
147cell surface receptor signaling pathway involved in heart development (GO:0061311)2.80759693
148apoptotic process involved in morphogenesis (GO:0060561)2.80383386
149ethanol oxidation (GO:0006069)2.79761663
150detection of bacterium (GO:0016045)2.79676072
151negative regulation of smooth muscle cell differentiation (GO:0051151)2.79610815
152cell fate commitment involved in formation of primary germ layer (GO:0060795)2.79286504
153regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.79209103
154regulation of integrin-mediated signaling pathway (GO:2001044)2.78828781
155regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.76615918
156generation of neurons (GO:0048699)2.75449304
157cell-substrate junction assembly (GO:0007044)2.74402428
158wound healing, spreading of epidermal cells (GO:0035313)2.71714850
159positive regulation of pseudopodium assembly (GO:0031274)2.70452627
160lateral sprouting from an epithelium (GO:0060601)2.70138749
161prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.69726386
162negative regulation of cartilage development (GO:0061037)2.69633843
163pre-miRNA processing (GO:0031054)2.69604748
164midgut development (GO:0007494)2.69591640
165regulation of transforming growth factor beta1 production (GO:0032908)2.69562641
166membrane budding (GO:0006900)2.69027101
167renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.68661001
168positive regulation of actin filament depolymerization (GO:0030836)2.67502568
169embryonic placenta development (GO:0001892)2.67154716
170branched-chain amino acid catabolic process (GO:0009083)2.67029433
171apoptotic cell clearance (GO:0043277)2.64463986
172regulation of water loss via skin (GO:0033561)2.64167320
173head development (GO:0060322)2.63563394
174establishment of epithelial cell polarity (GO:0090162)2.63095236
175ectodermal placode formation (GO:0060788)2.60779078
176cellular response to arsenic-containing substance (GO:0071243)2.60622111
177regulation of cell fate specification (GO:0042659)2.60067936
178bone morphogenesis (GO:0060349)2.59638710

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.88957186
2* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.17005982
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.68532201
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.29831334
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.95380638
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.64211654
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.61900564
8TAF15_26573619_Chip-Seq_HEK293_Human3.29302207
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.23071543
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.96400206
11ZNF263_19887448_ChIP-Seq_K562_Human2.95273091
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.92935525
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.90612077
14ESR1_15608294_ChIP-ChIP_MCF-7_Human2.70420336
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46739824
16EWS_26573619_Chip-Seq_HEK293_Human2.43385777
17CLOCK_20551151_ChIP-Seq_293T_Human2.43059427
18SOX2_27498859_Chip-Seq_STOMACH_Mouse2.35081463
19* P300_19829295_ChIP-Seq_ESCs_Human2.34658550
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33383385
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.27241566
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.25121384
23FOXO3_23340844_ChIP-Seq_DLD1_Human2.19087017
24SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.10420748
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.01973771
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.01973771
27* SOX2_20726797_ChIP-Seq_SW620_Human1.98715301
28CDX2_20551321_ChIP-Seq_CACO-2_Human1.98083480
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.97699102
30ARNT_22903824_ChIP-Seq_MCF-7_Human1.97181218
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.91930374
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.91930374
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.91930374
34RACK7_27058665_Chip-Seq_MCF-7_Human1.91861961
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.91366552
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.90748146
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.88476836
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87858177
39GBX2_23144817_ChIP-Seq_PC3_Human1.86469146
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.84151535
41GATA4_25053715_ChIP-Seq_YYC3_Human1.75657164
42ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.74512107
43SMAD3_21741376_ChIP-Seq_HESCs_Human1.72484309
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.70678027
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68018597
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67862199
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65551009
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65051073
49RUNX1_27514584_Chip-Seq_MCF-7_Human1.63255058
50* GATA6_25053715_ChIP-Seq_YYC3_Human1.62983450
51* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62797301
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.62772650
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59572028
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58858233
55NANOG_16153702_ChIP-ChIP_HESCs_Human1.58825871
56SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.56022273
57AR_21909140_ChIP-Seq_LNCAP_Human1.53647856
58P63_26484246_Chip-Seq_KERATINOCYTES_Human1.53577015
59STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.52507998
60FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.52108267
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51313313
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50689900
63ATF3_27146783_Chip-Seq_COLON_Human1.49773295
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49737069
65ISL1_27105846_Chip-Seq_CPCs_Mouse1.49456090
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.49343665
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46287055
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43817516
69PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.42680080
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42608268
71EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.41265966
72FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.37951148
73CJUN_26792858_Chip-Seq_BT549_Human1.36829133
74KLF5_25053715_ChIP-Seq_YYC3_Human1.35873692
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35780036
76VDR_22108803_ChIP-Seq_LS180_Human1.35203339
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33496261
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33254146
79SMAD4_21799915_ChIP-Seq_A2780_Human1.33127666
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.31970890
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31486945
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.31410006
83TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.29177433
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29067566
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.28737783
86* GATA3_24758297_ChIP-Seq_MCF-7_Human1.27950952
87CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27603833
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25276177
89AR_21572438_ChIP-Seq_LNCaP_Human1.24946108
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24766738
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24474646
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22565755
93ELK1_22589737_ChIP-Seq_MCF10A_Human1.21422442
94SMAD4_21741376_ChIP-Seq_HESCs_Human1.21199611
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20311155
96PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.19792962
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19558419
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19555512
99P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19343744
100* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19207794
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19024840
102PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18037079
103CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17354515
104AHR_22903824_ChIP-Seq_MCF-7_Human1.16841769
105FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.16230835
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15516503
107ELK3_25401928_ChIP-Seq_HUVEC_Human1.14546114
108TCF4_22108803_ChIP-Seq_LS180_Human1.14524420
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14375058
110SALL1_21062744_ChIP-ChIP_HESCs_Human1.14295052
111ELF5_23300383_ChIP-Seq_T47D_Human1.14006557
112FUS_26573619_Chip-Seq_HEK293_Human1.13537581
113STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12682832
114SMAD4_21741376_ChIP-Seq_EPCs_Human1.12076403
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12005428
116TP53_18474530_ChIP-ChIP_U2OS_Human1.11694393
117WT1_19549856_ChIP-ChIP_CCG9911_Human1.11500911
118RUNX2_22187159_ChIP-Seq_PCA_Human1.10904007
119JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10637452
120NANOG_18692474_ChIP-Seq_MEFs_Mouse1.10578001
121SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09076870
122FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08745670
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07815454
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07698111
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07518770
126NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.07113309
127TCF4_18268006_ChIP-ChIP_LS174T_Human1.06643597
128LXR_22292898_ChIP-Seq_THP-1_Human1.05994545
129FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05485985
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04999394
131BRD4_25478319_ChIP-Seq_HGPS_Human1.04023604
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03367213
133ETV1_20927104_ChIP-Seq_GIST48_Human1.03244455
134UBF1/2_26484160_Chip-Seq_HMECs_Human1.03234453
135STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02824101
136TBL1_22424771_ChIP-Seq_293T_Human1.02479378
137SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01954951
138NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01648352
139TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00863335
140RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00321524
141SOX2_16153702_ChIP-ChIP_HESCs_Human1.00308836
142UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00003605
143TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99612193
144* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99594433
145CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99545208
146RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99494658
147RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99302520
148CHD1_26751641_Chip-Seq_LNCaP_Human0.98918284
149NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98524551
150SMAD3_21741376_ChIP-Seq_EPCs_Human0.98336320
151TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98232829
152ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97820633
153* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96126959
154RXR_22158963_ChIP-Seq_LIVER_Mouse0.95965982
155CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95210175
156NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94302742
157ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94000640
158ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93738412
159ERG_21242973_ChIP-ChIP_JURKAT_Human0.92802226
160* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90624787
161* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90624787
162NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90257486
163* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.89838006
164PPARA_22158963_ChIP-Seq_LIVER_Mouse0.89140496
165TP63_23658742_ChIP-Seq_EP156T_Human0.88293218
166ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87608277

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.63230652
2MP0000537_abnormal_urethra_morphology3.81513777
3MP0010678_abnormal_skin_adnexa3.39242473
4MP0004264_abnormal_extraembryonic_tissu3.31269308
5MP0006054_spinal_hemorrhage2.91324500
6MP0005377_hearing/vestibular/ear_phenot2.83024015
7MP0003878_abnormal_ear_physiology2.83024015
8MP0003195_calcinosis2.63289613
9MP0002796_impaired_skin_barrier2.62171150
10MP0003566_abnormal_cell_adhesion2.61475119
11MP0003453_abnormal_keratinocyte_physiol2.58112039
12MP0000383_abnormal_hair_follicle2.49234039
13MP0002098_abnormal_vibrissa_morphology2.46493539
14MP0000579_abnormal_nail_morphology2.41440226
15MP0002254_reproductive_system_inflammat2.41129966
16MP0010352_gastrointestinal_tract_polyps2.38234381
17MP0003136_yellow_coat_color2.27958403
18MP0005248_abnormal_Harderian_gland2.18733741
19MP0004782_abnormal_surfactant_physiolog2.15008329
20MP0002138_abnormal_hepatobiliary_system2.14531555
21MP0002938_white_spotting2.11803972
22MP0005646_abnormal_pituitary_gland2.04109651
23MP0003938_abnormal_ear_development2.01214613
24MP0001958_emphysema2.00784023
25MP0005275_abnormal_skin_tensile1.98046636
26MP0010030_abnormal_orbit_morphology1.92103594
27MP0003300_gastrointestinal_ulcer1.89617611
28MP0001485_abnormal_pinna_reflex1.89457627
29MP0004272_abnormal_basement_membrane1.89007989
30MP0005083_abnormal_biliary_tract1.85431988
31MP0001849_ear_inflammation1.79399776
32MP0009780_abnormal_chondrocyte_physiolo1.76422641
33MP0005501_abnormal_skin_physiology1.70906643
34MP0009053_abnormal_anal_canal1.69985479
35MP0002282_abnormal_trachea_morphology1.66396626
36MP0002060_abnormal_skin_morphology1.62898395
37MP0003941_abnormal_skin_development1.59639949
38MP0000566_synostosis1.58947970
39MP0000762_abnormal_tongue_morphology1.57664803
40MP0000428_abnormal_craniofacial_morphol1.56735617
41MP0003705_abnormal_hypodermis_morpholog1.55259253
42MP0005023_abnormal_wound_healing1.47506700
43MP0000467_abnormal_esophagus_morphology1.47482197
44MP0005257_abnormal_intraocular_pressure1.46504427
45MP0001216_abnormal_epidermal_layer1.46310430
46MP0008875_abnormal_xenobiotic_pharmacok1.45263110
47MP0000627_abnormal_mammary_gland1.41356157
48MP0000377_abnormal_hair_follicle1.34681778
49MP0004957_abnormal_blastocyst_morpholog1.31150047
50MP0000462_abnormal_digestive_system1.30156922
51MP0004133_heterotaxia1.29810714
52MP0003718_maternal_effect1.28096918
53MP0001286_abnormal_eye_development1.27465552
54MP0002234_abnormal_pharynx_morphology1.27332401
55MP0003115_abnormal_respiratory_system1.26315049
56MP0009697_abnormal_copulation1.25915349
57MP0005167_abnormal_blood-brain_barrier1.24092615
58MP0010771_integument_phenotype1.19344719
59MP0009278_abnormal_bone_marrow1.19201972
60MP0003119_abnormal_digestive_system1.13260300
61MP0005075_abnormal_melanosome_morpholog1.13079233
62MP0001545_abnormal_hematopoietic_system1.11167949
63MP0005397_hematopoietic_system_phenotyp1.11167949
64MP0002009_preneoplasia1.10859556
65MP0004147_increased_porphyrin_level1.10003989
66MP0005076_abnormal_cell_differentiation1.09518221
67MP0000647_abnormal_sebaceous_gland1.08481068
68MP0002233_abnormal_nose_morphology1.04272897
69MP0000372_irregular_coat_pigmentation1.03545530
70MP0001346_abnormal_lacrimal_gland1.03273447
71MP0000427_abnormal_hair_cycle1.02011074
72MP0002088_abnormal_embryonic_growth/wei1.01699443
73MP0003984_embryonic_growth_retardation1.01409651
74MP0001672_abnormal_embryogenesis/_devel0.99528204
75MP0005380_embryogenesis_phenotype0.99528204
76MP0002295_abnormal_pulmonary_circulatio0.98363176
77MP0004019_abnormal_vitamin_homeostasis0.98209264
78MP0002697_abnormal_eye_size0.97658400
79MP0002111_abnormal_tail_morphology0.97245824
80MP0003890_abnormal_embryonic-extraembry0.95800024
81MP0002085_abnormal_embryonic_tissue0.95572990
82MP0008789_abnormal_olfactory_epithelium0.94908176
83MP0002133_abnormal_respiratory_system0.93879466
84MP0005388_respiratory_system_phenotype0.93879466
85MP0005220_abnormal_exocrine_pancreas0.93644142
86MP0002396_abnormal_hematopoietic_system0.93232890
87MP0001293_anophthalmia0.93061620
88MP0001697_abnormal_embryo_size0.92670503
89MP0003943_abnormal_hepatobiliary_system0.92574719
90MP0009672_abnormal_birth_weight0.91982903
91MP0002086_abnormal_extraembryonic_tissu0.90010463
92MP0003329_amyloid_beta_deposits0.89235083
93MP0000516_abnormal_urinary_system0.88073952
94MP0005367_renal/urinary_system_phenotyp0.88073952
95MP0005164_abnormal_response_to0.87825520
96MP0003787_abnormal_imprinting0.86838814
97MP0006138_congestive_heart_failure0.86337370
98MP0008004_abnormal_stomach_pH0.85254689
99MP0008877_abnormal_DNA_methylation0.84511464
100MP0003828_pulmonary_edema0.84037122
101MP0003693_abnormal_embryo_hatching0.83531942
102MP0002139_abnormal_hepatobiliary_system0.83511295
103MP0009384_cardiac_valve_regurgitation0.82379297
104MP0009703_decreased_birth_body0.82370321
105MP0003942_abnormal_urinary_system0.81820885
106MP0005187_abnormal_penis_morphology0.80620983
107MP0000631_abnormal_neuroendocrine_gland0.80411749
108MP0000465_gastrointestinal_hemorrhage0.78639842
109MP0003935_abnormal_craniofacial_develop0.78374016
110MP0008995_early_reproductive_senescence0.77053751
111MP0001661_extended_life_span0.76699107
112MP0001340_abnormal_eyelid_morphology0.76679354
113MP0000470_abnormal_stomach_morphology0.76436879
114MP0002928_abnormal_bile_duct0.76205704
115MP0010368_abnormal_lymphatic_system0.76034135
116MP0001963_abnormal_hearing_physiology0.75207978
117MP0002092_abnormal_eye_morphology0.74159406
118MP0005394_taste/olfaction_phenotype0.74047847
119MP0005499_abnormal_olfactory_system0.74047847
120MP0004185_abnormal_adipocyte_glucose0.73230693
121MP0005165_increased_susceptibility_to0.73199433
122MP0000477_abnormal_intestine_morphology0.73153259
123MP0002084_abnormal_developmental_patter0.73134531
124MP0003252_abnormal_bile_duct0.72954131
125MP0002925_abnormal_cardiovascular_devel0.72010869
126MP0005408_hypopigmentation0.70419486
127MP0004947_skin_inflammation0.69090699
128MP0003283_abnormal_digestive_organ0.69078334
129MP0002909_abnormal_adrenal_gland0.67840557
130MP0002168_other_aberrant_phenotype0.67200069
131MP0000026_abnormal_inner_ear0.67018820
132MP0005395_other_phenotype0.66830855
133MP0003936_abnormal_reproductive_system0.66387705
134MP0001879_abnormal_lymphatic_vessel0.66160332
135MP0008775_abnormal_heart_ventricle0.66022688
136MP0003385_abnormal_body_wall0.65828540
137MP0005166_decreased_susceptibility_to0.65618351
138MP0003567_abnormal_fetal_cardiomyocyte0.65234659
139MP0000343_altered_response_to0.65182841
140MP0004197_abnormal_fetal_growth/weight/0.65092868
141MP0000432_abnormal_head_morphology0.64901326
142MP0003045_fibrosis0.64741533
143MP0003755_abnormal_palate_morphology0.64234551
144MP0009931_abnormal_skin_appearance0.63864267
145MP0001784_abnormal_fluid_regulation0.63836895
146MP0008932_abnormal_embryonic_tissue0.63686722
147MP0010155_abnormal_intestine_physiology0.62678901
148MP0005085_abnormal_gallbladder_physiolo0.62308165
149MP0003937_abnormal_limbs/digits/tail_de0.61482035
150MP0004381_abnormal_hair_follicle0.60946839

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)5.79571916
2Cervical subluxation (HP:0003308)5.79269521
3Posterior subcapsular cataract (HP:0007787)5.52189032
4Right ventricular cardiomyopathy (HP:0011663)5.21260624
5Pustule (HP:0200039)5.20798674
6Vacuolated lymphocytes (HP:0001922)5.04785846
7Morphological abnormality of the middle ear (HP:0008609)4.83987801
8Proximal tubulopathy (HP:0000114)4.73159179
9Pili torti (HP:0003777)4.55318813
10Milia (HP:0001056)4.54351250
11Alopecia of scalp (HP:0002293)4.53502096
12Fragile nails (HP:0001808)4.43975787
13Ulnar bowing (HP:0003031)4.26353295
14Interstitial pulmonary disease (HP:0006530)4.14344470
15Ulnar deviation of the wrist (HP:0003049)3.98187309
16Woolly hair (HP:0002224)3.97415465
17Micronodular cirrhosis (HP:0001413)3.95479140
18Genetic anticipation (HP:0003743)3.94318647
19Plantar hyperkeratosis (HP:0007556)3.87548924
20Atrophic scars (HP:0001075)3.73547968
21Subacute progressive viral hepatitis (HP:0006572)3.47257558
22Disproportionate short-trunk short stature (HP:0003521)3.46637649
23Subcapsular cataract (HP:0000523)3.43144848
24Gout (HP:0001997)3.42554171
25Arterial tortuosity (HP:0005116)3.40820460
26Abnormal hemoglobin (HP:0011902)3.30101406
27Fused cervical vertebrae (HP:0002949)3.30058385
28Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.29629102
29Short 1st metacarpal (HP:0010034)3.29629102
30Intrahepatic cholestasis (HP:0001406)3.28452532
31Hematochezia (HP:0002573)3.28214395
32Bile duct proliferation (HP:0001408)3.23917727
33Abnormal biliary tract physiology (HP:0012439)3.23917727
34Polycythemia (HP:0001901)3.19049137
35Nail dystrophy (HP:0008404)3.17924935
36Esophageal varix (HP:0002040)3.17405959
37Absent eyebrow (HP:0002223)3.16401711
38Cutaneous finger syndactyly (HP:0010554)3.15186301
39Bilateral microphthalmos (HP:0007633)3.09551491
40Aplasia/Hypoplasia of the sternum (HP:0006714)3.08126905
41Vascular tortuosity (HP:0004948)3.02285003
42Bronchomalacia (HP:0002780)3.01769295
43Abnormality of the lacrimal duct (HP:0011481)3.01315964
44Asymmetry of the thorax (HP:0001555)2.91404440
45Bowed forearm bones (HP:0003956)2.91189790
46Bowing of the arm (HP:0006488)2.91189790
47Bifid tongue (HP:0010297)2.91160501
48Glomerulosclerosis (HP:0000096)2.88008212
49Abnormality of the 1st metacarpal (HP:0010009)2.85074319
50Delayed epiphyseal ossification (HP:0002663)2.84109959
51Malnutrition (HP:0004395)2.83322213
52Beaking of vertebral bodies (HP:0004568)2.79857337
53Chronic bronchitis (HP:0004469)2.79765629
54Broad nasal tip (HP:0000455)2.79645914
55Short hallux (HP:0010109)2.78209708
56Hypophosphatemic rickets (HP:0004912)2.78110531
57Cerebral aneurysm (HP:0004944)2.76848703
58Hypotrichosis (HP:0001006)2.76228684
59Abnormal blistering of the skin (HP:0008066)2.75196054
60Cutaneous syndactyly (HP:0012725)2.74876290
61Ventricular tachycardia (HP:0004756)2.74397652
62Long nose (HP:0003189)2.72926007
63Renal salt wasting (HP:0000127)2.71647778
64Curly hair (HP:0002212)2.70754173
65Gonadotropin excess (HP:0000837)2.67382180
66Abnormal hair laboratory examination (HP:0003328)2.65985955
67Anophthalmia (HP:0000528)2.64445942
68Aplasia/Hypoplasia of the hallux (HP:0008362)2.64231328
69Tubulointerstitial fibrosis (HP:0005576)2.63076736
70Biliary tract neoplasm (HP:0100574)2.58929641
71Focal segmental glomerulosclerosis (HP:0000097)2.58351647
72Osteomalacia (HP:0002749)2.58305771
73Esophageal atresia (HP:0002032)2.57984641
74Abnormality of the nasal septum (HP:0000419)2.57082655
75Abnormality of the gastric mucosa (HP:0004295)2.55686423
76Bicornuate uterus (HP:0000813)2.54425170
77Bundle branch block (HP:0011710)2.53568267
78Abnormality of the nasolacrimal system (HP:0000614)2.51105876
79Abnormal auditory evoked potentials (HP:0006958)2.48362302
80Palmoplantar hyperkeratosis (HP:0000972)2.46791886
81Hyperactive renin-angiotensin system (HP:0000841)2.40007780
82Annular pancreas (HP:0001734)2.38780744
83Flared iliac wings (HP:0002869)2.37440323
84Abnormality of monocarboxylic acid metabolism (HP:0010996)2.37037905
85Absent eyelashes (HP:0000561)2.36694917
86Palpitations (HP:0001962)2.36248636
87Facial cleft (HP:0002006)2.35785842
88Scanning speech (HP:0002168)2.35746034
89Palmar hyperkeratosis (HP:0010765)2.35528927
90Hypoplastic labia majora (HP:0000059)2.32967911
91Choanal stenosis (HP:0000452)2.32768735
92Abnormality of the middle phalanges of the toes (HP:0010183)2.32622641
93Hypoplasia of the odontoid process (HP:0003311)2.30269291
94Turricephaly (HP:0000262)2.29075018
95Widely spaced teeth (HP:0000687)2.27001668
96Hyperglycinemia (HP:0002154)2.26926989
97Progressive cerebellar ataxia (HP:0002073)2.26567605
98Abnormality of the nasal mucosa (HP:0000433)2.25526276
99Hypoplasia of dental enamel (HP:0006297)2.25210724
100Wide nose (HP:0000445)2.23994059
101Abnormality of dental color (HP:0011073)2.23015292
102Partial agenesis of the corpus callosum (HP:0001338)2.22102459
103Gastrointestinal carcinoma (HP:0002672)2.20657047
104Malignant gastrointestinal tract tumors (HP:0006749)2.20657047
105Rectal prolapse (HP:0002035)2.20283994
106Wide intermamillary distance (HP:0006610)2.19743966
107Stenosis of the external auditory canal (HP:0000402)2.19674459
108Enlarged epiphyses (HP:0010580)2.17498877
109Nasal speech (HP:0001611)2.17485728
110Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16987468
111Cupped ear (HP:0000378)2.15322877
112Synostosis involving the elbow (HP:0003938)2.14322043
113Humeroradial synostosis (HP:0003041)2.14322043
114Vascular calcification (HP:0004934)2.12680420
115Aortic aneurysm (HP:0004942)2.12050676
116Labial hypoplasia (HP:0000066)2.11396743
117Coronal craniosynostosis (HP:0004440)2.11256649
118Spastic diplegia (HP:0001264)2.10335292
119Anal stenosis (HP:0002025)2.07981622
120Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.07750412
121Abnormality of the labia majora (HP:0012881)2.07688575
122Dysmetric saccades (HP:0000641)2.06967336
123Pterygium (HP:0001059)2.04677784
124Gastrointestinal atresia (HP:0002589)2.04091707
125Lymphangioma (HP:0100764)2.04088552
126Vaginal fistula (HP:0004320)2.03911917
127Abnormality of the labia minora (HP:0012880)2.03674963
128Decreased lacrimation (HP:0000633)2.00718821
129Aortic dissection (HP:0002647)2.00677986
130Severe Myopia (HP:0011003)1.99904761
131Amelogenesis imperfecta (HP:0000705)1.99714229
132Concave nail (HP:0001598)1.98855187
133Uterine neoplasm (HP:0010784)1.98804770
134Thin bony cortex (HP:0002753)1.98709432
135Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.98635227
136Cardiovascular calcification (HP:0011915)1.96190306
137Aplasia cutis congenita (HP:0001057)1.94732587
138Abnormality of the proximal phalanges of the hand (HP:0009834)1.93868952
139Germ cell neoplasia (HP:0100728)1.93381377
140Popliteal pterygium (HP:0009756)1.93373196
141Dysdiadochokinesis (HP:0002075)1.92932494
142Aortic valve stenosis (HP:0001650)1.90924332
143High anterior hairline (HP:0009890)1.90785358
144Myelomeningocele (HP:0002475)1.90233901
145Tubular atrophy (HP:0000092)1.89407890
146Patchy hypopigmentation of hair (HP:0011365)1.88757332
147Hypoplastic female external genitalia (HP:0012815)1.88639948
148Severe short stature (HP:0003510)1.88455170
149Blepharitis (HP:0000498)1.87555727
150Abnormality of the distal phalanges of the toes (HP:0010182)1.86666164
151Underdeveloped nasal alae (HP:0000430)1.86491741
152Lip pit (HP:0100267)1.86433129
153Short phalanx of the thumb (HP:0009660)1.85782492
154Abnormality of the columella (HP:0009929)1.84051124
155Abnormality of homocysteine metabolism (HP:0010919)1.82992380
156Homocystinuria (HP:0002156)1.82992380
157Thyroid-stimulating hormone excess (HP:0002925)1.82484421
158Selective tooth agenesis (HP:0001592)1.81964317
159Poikiloderma (HP:0001029)1.81739631
160Ureteral stenosis (HP:0000071)1.81253917
161Abnormality of the pubic bones (HP:0003172)1.81213767
162Scrotal hypoplasia (HP:0000046)1.80960904
163Absent hair (HP:0002298)1.80748804
164Cheilitis (HP:0100825)1.79767194
165Bifid scrotum (HP:0000048)1.79194887
166Tubulointerstitial nephritis (HP:0001970)1.78398977
167Short humerus (HP:0005792)1.78377586
168Aneurysm (HP:0002617)1.76890164
169Fragile skin (HP:0001030)1.73271873
170Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.73108519
171Vertebral hypoplasia (HP:0008417)1.73108519
172Cone-rod dystrophy (HP:0000548)1.73042759
173Shawl scrotum (HP:0000049)1.71921254
174Ureteral obstruction (HP:0006000)1.70342919
175Ridged nail (HP:0001807)1.70213577
176Breast carcinoma (HP:0003002)1.69633852
177Visceral angiomatosis (HP:0100761)1.68776933
178Increased purine levels (HP:0004368)1.68206584
179Hyperuricemia (HP:0002149)1.68206584
180Shallow orbits (HP:0000586)1.67682217
181Spondylolisthesis (HP:0003302)1.66350854
182Corneal erosion (HP:0200020)1.66298957
183Trismus (HP:0000211)1.63805640
184Ankle contracture (HP:0006466)1.62298427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.05713114
2PIK3CA6.09340597
3TNIK4.16890684
4OXSR13.88963583
5PLK43.22925842
6MST43.04830645
7FER2.97527256
8TRIM282.83864223
9FRK2.58119075
10LATS12.55463532
11ERBB32.55236535
12SIK32.51258213
13PAK42.50902449
14RPS6KB22.40857846
15TRPM72.32024807
16DDR22.30330840
17NLK2.25612000
18MST1R2.12564003
19MATK2.10751684
20MAP3K22.09656008
21MAPK152.03046699
22EPHB22.00963065
23NUAK11.91757269
24ACVR1B1.86650215
25PTK61.83690051
26TGFBR21.83014276
27RIPK11.77329232
28PTK21.75122773
29CDK61.70494952
30MAP3K121.65569418
31BMPR1B1.64180598
32FGFR21.61351380
33ICK1.55871546
34LRRK21.55018604
35MKNK11.51944049
36DYRK1B1.47884629
37EPHB11.46640724
38MAP3K31.42452706
39PDGFRA1.42116963
40BCKDK1.40719129
41CDK191.38277560
42BMX1.36401210
43PASK1.35629080
44TRIB31.33101466
45SRPK11.29990094
46MET1.26456826
47STK101.21991956
48MAP3K91.19473570
49MAP3K111.19283901
50ERBB21.15545301
51CSK1.14668849
52STK31.13954028
53TYRO31.11777274
54NEK91.11546464
55FGR1.10343406
56MAP3K61.08252629
57MAP2K21.06030283
58MKNK21.02154285
59TESK11.01998121
60PDGFRB0.98678873
61STK160.95876384
62TTN0.94860989
63DAPK10.93574916
64MAP2K60.93079023
65MYLK0.92354573
66FGFR10.92025273
67GSK3A0.85964455
68PIK3CG0.85914711
69LATS20.84986240
70PKN20.81805720
71MAP2K10.79833009
72PIM20.79719109
73CSNK1G10.79248592
74EGFR0.76092676
75PAK30.74331374
76SIK10.74321735
77TIE10.73894994
78STK38L0.69798357
79CSNK1A1L0.69696176
80PRKCE0.66694274
81GRK10.66300914
82LMTK20.64637949
83PLK30.63068533
84EPHA30.61879264
85MAPKAPK30.61063856
86ZAP700.60702239
87PRKCI0.60572305
88KSR20.59138566
89CSNK1G30.58293657
90NME10.54453358
91ERN10.53445516
92PLK10.52750895
93MAPKAPK50.52629190
94CHUK0.52322264
95ILK0.51338765
96MELK0.50978044
97SCYL20.50282230
98PRKD10.48734570
99AKT30.48387576
100CAMK2B0.46745323
101ABL10.44889661
102TGFBR10.43817602
103SRC0.42623539
104BCR0.40442192
105CDC70.39396716
106LIMK10.38888363
107CSNK1G20.38458718
108MINK10.38346576
109FGFR40.37671807
110STK390.37243324
111CDK30.37189974
112CAMK2G0.36941302
113DMPK0.35850607
114PRKD20.35580992
115EEF2K0.35395136
116TTK0.34989621
117MTOR0.34013984
118MAP3K80.33824649
119PDK20.32746264
120BRD40.31125903
121AURKB0.31097594
122CSNK1E0.29853630
123STK380.28653927
124FGFR30.28537303
125CSNK1A10.28390330
126RPS6KC10.27630363
127RPS6KL10.27630363
128JAK10.26839241
129PRKG20.26707375
130PLK20.25601183
131RPS6KA10.24681338
132DAPK30.24634830
133YES10.24307163
134FLT30.23762136
135ROCK20.23467124
136INSR0.23350137
137AKT20.22618590
138DYRK30.22457267
139RET0.19162810
140CDK90.18563065
141TAF10.18477357
142ROCK10.16855624
143EIF2AK20.15277753
144ERBB40.13089016
145ATM0.12784099
146CLK10.11536167
147PRKCH0.11359374

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045203.32380080
2Hippo signaling pathway_Homo sapiens_hsa043902.89410817
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.80100653
4Tight junction_Homo sapiens_hsa045302.76087128
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.72545480
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.61773838
7ECM-receptor interaction_Homo sapiens_hsa045122.50070458
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.41348944
9Glutathione metabolism_Homo sapiens_hsa004802.40009451
10Galactose metabolism_Homo sapiens_hsa000522.35710281
11Fatty acid biosynthesis_Homo sapiens_hsa000612.35547336
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.34828484
13Other glycan degradation_Homo sapiens_hsa005112.31717805
14Bladder cancer_Homo sapiens_hsa052192.31288776
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.25681797
16Chemical carcinogenesis_Homo sapiens_hsa052042.22841874
17Small cell lung cancer_Homo sapiens_hsa052222.21055812
18Proteoglycans in cancer_Homo sapiens_hsa052052.02425240
19Glycosaminoglycan degradation_Homo sapiens_hsa005312.01463272
20TGF-beta signaling pathway_Homo sapiens_hsa043501.97172917
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.87156964
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.86706055
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85563078
24Thyroid cancer_Homo sapiens_hsa052161.84331381
25Focal adhesion_Homo sapiens_hsa045101.83436692
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.81211911
27Basal cell carcinoma_Homo sapiens_hsa052171.80839478
28Propanoate metabolism_Homo sapiens_hsa006401.63562933
29Pancreatic cancer_Homo sapiens_hsa052121.62715661
30Hedgehog signaling pathway_Homo sapiens_hsa043401.58808313
31Steroid biosynthesis_Homo sapiens_hsa001001.57957859
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.53131835
33One carbon pool by folate_Homo sapiens_hsa006701.44843172
34Endometrial cancer_Homo sapiens_hsa052131.40886158
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40851651
36Selenocompound metabolism_Homo sapiens_hsa004501.40791403
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39051089
38Chronic myeloid leukemia_Homo sapiens_hsa052201.38754299
39Histidine metabolism_Homo sapiens_hsa003401.38592588
40Amoebiasis_Homo sapiens_hsa051461.38497992
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.37765942
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34876560
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.34025349
44Mineral absorption_Homo sapiens_hsa049781.33628595
45Colorectal cancer_Homo sapiens_hsa052101.31757999
46Phototransduction_Homo sapiens_hsa047441.31472568
47Pertussis_Homo sapiens_hsa051331.30701475
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29978859
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.29767651
50Shigellosis_Homo sapiens_hsa051311.26534802
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23864137
52Sphingolipid metabolism_Homo sapiens_hsa006001.23575771
53MicroRNAs in cancer_Homo sapiens_hsa052061.22016242
54Basal transcription factors_Homo sapiens_hsa030221.21833108
55Protein digestion and absorption_Homo sapiens_hsa049741.21600551
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19648145
57Ether lipid metabolism_Homo sapiens_hsa005651.18927666
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18819434
59Folate biosynthesis_Homo sapiens_hsa007901.18621502
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.18563873
61Non-homologous end-joining_Homo sapiens_hsa034501.18045304
62Sulfur relay system_Homo sapiens_hsa041221.14694412
63Longevity regulating pathway - mammal_Homo sapiens_hsa042111.11284609
64Regulation of actin cytoskeleton_Homo sapiens_hsa048101.09822295
65Toxoplasmosis_Homo sapiens_hsa051451.08369318
66p53 signaling pathway_Homo sapiens_hsa041151.06339724
67Renal cell carcinoma_Homo sapiens_hsa052111.05886091
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05715439
69Pathways in cancer_Homo sapiens_hsa052001.03426159
70Viral myocarditis_Homo sapiens_hsa054161.00523750
71Wnt signaling pathway_Homo sapiens_hsa043100.98521812
72Salmonella infection_Homo sapiens_hsa051320.97031597
73TNF signaling pathway_Homo sapiens_hsa046680.96474871
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94866638
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94748223
76RNA transport_Homo sapiens_hsa030130.93739516
77VEGF signaling pathway_Homo sapiens_hsa043700.93334156
78Rheumatoid arthritis_Homo sapiens_hsa053230.89596385
79Phenylalanine metabolism_Homo sapiens_hsa003600.89245750
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88892830
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88234562
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86804799
83Homologous recombination_Homo sapiens_hsa034400.85682707
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85550132
85Endocytosis_Homo sapiens_hsa041440.85203782
86mTOR signaling pathway_Homo sapiens_hsa041500.84431762
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83780718
88Notch signaling pathway_Homo sapiens_hsa043300.83187416
89mRNA surveillance pathway_Homo sapiens_hsa030150.81987628
90Tryptophan metabolism_Homo sapiens_hsa003800.79394051
91Hepatitis C_Homo sapiens_hsa051600.78372834
92Vitamin digestion and absorption_Homo sapiens_hsa049770.78112023
93Prostate cancer_Homo sapiens_hsa052150.75579898
94Melanogenesis_Homo sapiens_hsa049160.74496691
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74268300
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74251802
97Mismatch repair_Homo sapiens_hsa034300.74160165
98Rap1 signaling pathway_Homo sapiens_hsa040150.73161419
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72129979
100Axon guidance_Homo sapiens_hsa043600.70166037
101Fanconi anemia pathway_Homo sapiens_hsa034600.69531018
102RNA degradation_Homo sapiens_hsa030180.67619549
103PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66843461
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.63584699
105Dorso-ventral axis formation_Homo sapiens_hsa043200.63138765
106Vibrio cholerae infection_Homo sapiens_hsa051100.60298287
107Retinol metabolism_Homo sapiens_hsa008300.58826912
108Malaria_Homo sapiens_hsa051440.58357517
109HTLV-I infection_Homo sapiens_hsa051660.57308938
110Cell cycle_Homo sapiens_hsa041100.57243441
111Fatty acid degradation_Homo sapiens_hsa000710.56469471
112Lysosome_Homo sapiens_hsa041420.56065393
113Oocyte meiosis_Homo sapiens_hsa041140.55703922
114Dilated cardiomyopathy_Homo sapiens_hsa054140.54637358
115Viral carcinogenesis_Homo sapiens_hsa052030.53658270
116Phagosome_Homo sapiens_hsa041450.52224139
117HIF-1 signaling pathway_Homo sapiens_hsa040660.51486452
118FoxO signaling pathway_Homo sapiens_hsa040680.51373855
119Caffeine metabolism_Homo sapiens_hsa002320.48434097
120Platelet activation_Homo sapiens_hsa046110.48216419
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.48124167
122Melanoma_Homo sapiens_hsa052180.48085246
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47479183
124ErbB signaling pathway_Homo sapiens_hsa040120.47444590
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46783586
126Sulfur metabolism_Homo sapiens_hsa009200.46133748
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.45697053
128Thyroid hormone synthesis_Homo sapiens_hsa049180.45647838
129Legionellosis_Homo sapiens_hsa051340.43875170
130Complement and coagulation cascades_Homo sapiens_hsa046100.42979510
131Fatty acid elongation_Homo sapiens_hsa000620.42374586
132Ovarian steroidogenesis_Homo sapiens_hsa049130.42362897
133Pentose phosphate pathway_Homo sapiens_hsa000300.41597801
134Apoptosis_Homo sapiens_hsa042100.41389536
135Starch and sucrose metabolism_Homo sapiens_hsa005000.40494597
136Hepatitis B_Homo sapiens_hsa051610.40045958
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39096484
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38393577
139Salivary secretion_Homo sapiens_hsa049700.38378469
140Arginine and proline metabolism_Homo sapiens_hsa003300.38230830
141Circadian rhythm_Homo sapiens_hsa047100.37811802
142Acute myeloid leukemia_Homo sapiens_hsa052210.37346508
143N-Glycan biosynthesis_Homo sapiens_hsa005100.36751706
144Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36565917
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35998404
146Estrogen signaling pathway_Homo sapiens_hsa049150.34757624
147Glioma_Homo sapiens_hsa052140.34215841
148Linoleic acid metabolism_Homo sapiens_hsa005910.34083681
149GnRH signaling pathway_Homo sapiens_hsa049120.33616399
150Bile secretion_Homo sapiens_hsa049760.33190306
151beta-Alanine metabolism_Homo sapiens_hsa004100.32675633
152Fatty acid metabolism_Homo sapiens_hsa012120.32666468
153ABC transporters_Homo sapiens_hsa020100.32476452
154Non-small cell lung cancer_Homo sapiens_hsa052230.32395910
155Peroxisome_Homo sapiens_hsa041460.30619534
156Metabolic pathways_Homo sapiens_hsa011000.28064196
157Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26386911
158Glucagon signaling pathway_Homo sapiens_hsa049220.26280959
159* Nicotine addiction_Homo sapiens_hsa050330.25257096
160Nucleotide excision repair_Homo sapiens_hsa034200.25072121

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