GABRQ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. This gene location is also the candidate region of two different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)6.07762038
2vocalization behavior (GO:0071625)5.46156886
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.27326647
4protein complex localization (GO:0031503)5.14103741
5opioid receptor signaling pathway (GO:0038003)5.11883187
6cellular protein complex localization (GO:0034629)5.07878600
7regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.05391895
8nuclear pore complex assembly (GO:0051292)4.76945180
9regulation of glutamate receptor signaling pathway (GO:1900449)4.68986293
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.67889154
11positive regulation of synaptic transmission, GABAergic (GO:0032230)4.55243552
12L-serine metabolic process (GO:0006563)4.41818968
13regulation of transmission of nerve impulse (GO:0051969)4.41451741
14presynaptic membrane assembly (GO:0097105)4.41270856
15neurotransmitter secretion (GO:0007269)4.39486510
16protein localization to synapse (GO:0035418)4.38836556
17postsynaptic membrane organization (GO:0001941)4.32869520
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.31819104
19neuron recognition (GO:0008038)4.30299154
20gamma-aminobutyric acid transport (GO:0015812)4.26515900
21negative regulation of synaptic transmission, GABAergic (GO:0032229)4.22663462
22gamma-aminobutyric acid signaling pathway (GO:0007214)4.21933552
23regulation of synaptic vesicle exocytosis (GO:2000300)4.21919977
24DNA unwinding involved in DNA replication (GO:0006268)4.18608392
25establishment of integrated proviral latency (GO:0075713)4.18279883
26regulation of glutamate secretion (GO:0014048)4.16039508
27proline transport (GO:0015824)4.14141779
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.12687508
29nuclear pore organization (GO:0006999)4.12332797
30transmission of nerve impulse (GO:0019226)4.07593200
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.07218298
32positive regulation of synapse assembly (GO:0051965)4.06093219
33synaptic vesicle exocytosis (GO:0016079)4.05379698
34mitotic sister chromatid cohesion (GO:0007064)3.96763401
35axonal fasciculation (GO:0007413)3.95818235
36synaptic vesicle maturation (GO:0016188)3.95583030
37neuromuscular process controlling posture (GO:0050884)3.92807748
38presynaptic membrane organization (GO:0097090)3.92740171
39glutamate receptor signaling pathway (GO:0007215)3.92147065
40locomotory exploration behavior (GO:0035641)3.88752897
41mitotic chromosome condensation (GO:0007076)3.84976912
42dendritic spine morphogenesis (GO:0060997)3.81530656
43* neurotransmitter transport (GO:0006836)3.77109785
44regulation of synaptic vesicle transport (GO:1902803)3.75809040
45regulation of gene silencing by RNA (GO:0060966)3.69923718
46regulation of posttranscriptional gene silencing (GO:0060147)3.69923718
47regulation of gene silencing by miRNA (GO:0060964)3.69923718
48paraxial mesoderm development (GO:0048339)3.68779057
49positive regulation of amino acid transport (GO:0051957)3.67350739
50startle response (GO:0001964)3.64555121
51female mating behavior (GO:0060180)3.64218407
52heterochromatin organization (GO:0070828)3.63550446
53response to histamine (GO:0034776)3.62940229
54neuronal action potential propagation (GO:0019227)3.62197935
55neurotransmitter catabolic process (GO:0042135)3.59198485
56synaptic transmission, glutamatergic (GO:0035249)3.58436067
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.58180573
58protein localization to chromosome, centromeric region (GO:0071459)3.57580430
59protein localization to kinetochore (GO:0034501)3.55445310
60glutamate secretion (GO:0014047)3.54681583
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.53626981
62mitotic metaphase plate congression (GO:0007080)3.53225449
63regulation of female receptivity (GO:0045924)3.51864495
64pre-miRNA processing (GO:0031054)3.50073956
65regulation of neurotransmitter levels (GO:0001505)3.49253113
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.47181264
67regulation of mitotic spindle organization (GO:0060236)3.45982683
68regulation of synaptic transmission, GABAergic (GO:0032228)3.45578278
69exploration behavior (GO:0035640)3.43584694
70neurotransmitter-gated ion channel clustering (GO:0072578)3.42150778
71neuron-neuron synaptic transmission (GO:0007270)3.40181872
72activation of protein kinase A activity (GO:0034199)3.39466017
73negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.38628304
74righting reflex (GO:0060013)3.36786159
75positive regulation of potassium ion transmembrane transport (GO:1901381)3.35605784
76layer formation in cerebral cortex (GO:0021819)3.33598077
77regulation of translational fidelity (GO:0006450)3.32853534
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.30892109
79response to auditory stimulus (GO:0010996)3.30401020
80DNA strand elongation involved in DNA replication (GO:0006271)3.29966766
81regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.28562923
82synapse assembly (GO:0007416)3.28314716
83pore complex assembly (GO:0046931)3.28198400
84regulation of synapse assembly (GO:0051963)3.27086163
85intraspecies interaction between organisms (GO:0051703)3.26509089
86social behavior (GO:0035176)3.26509089
87striatum development (GO:0021756)3.26305901
88NLS-bearing protein import into nucleus (GO:0006607)3.25090238
89negative regulation of amino acid transport (GO:0051956)3.21637343
90DNA replication checkpoint (GO:0000076)3.20091602
91long-term memory (GO:0007616)3.18887356
92regulation of protein kinase A signaling (GO:0010738)3.18789226
93DNA strand elongation (GO:0022616)3.17140014
94membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16834198
95regulation of respiratory system process (GO:0044065)3.15931123
96regulation of synaptic transmission, glutamatergic (GO:0051966)3.13431620
97regulation of vesicle fusion (GO:0031338)3.10548801
98mating behavior (GO:0007617)3.09551239
99regulation of long-term neuronal synaptic plasticity (GO:0048169)3.08885045
100regulation of neuronal synaptic plasticity (GO:0048168)3.08125374
101notochord development (GO:0030903)3.08098984
102apical protein localization (GO:0045176)3.07673479
103membrane hyperpolarization (GO:0060081)3.04634682
104regulation of excitatory postsynaptic membrane potential (GO:0060079)3.03088367
105regulation of cAMP-dependent protein kinase activity (GO:2000479)3.03079585
106neuronal ion channel clustering (GO:0045161)3.02924698
107mitotic sister chromatid segregation (GO:0000070)3.02733826
108sister chromatid segregation (GO:0000819)2.99527730
109regulation of postsynaptic membrane potential (GO:0060078)2.99514530
110chromatin remodeling at centromere (GO:0031055)2.98990632
111establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.97967503
112respiratory system process (GO:0003016)2.97646656
113regulation of penile erection (GO:0060405)2.97276870
114regulation of beta-amyloid formation (GO:1902003)2.96485721
115CENP-A containing nucleosome assembly (GO:0034080)2.96442440
116positive regulation of membrane potential (GO:0045838)2.95827057
117response to pheromone (GO:0019236)2.95599385
118regulation of spindle organization (GO:0090224)2.95219804
119regulation of respiratory gaseous exchange (GO:0043576)2.94615856
120cAMP-mediated signaling (GO:0019933)2.93352077
121regulation of amino acid transport (GO:0051955)2.93243400
122synaptic vesicle endocytosis (GO:0048488)2.91360530
123auditory behavior (GO:0031223)2.91314690
124positive regulation of SMAD protein import into nucleus (GO:0060391)2.90997313
125cerebellar Purkinje cell differentiation (GO:0021702)2.90977027
126DNA replication initiation (GO:0006270)2.90924688
127membrane depolarization during action potential (GO:0086010)2.90706443
128dendrite development (GO:0016358)2.87891657
129neuropeptide signaling pathway (GO:0007218)2.87824814
130synapse organization (GO:0050808)2.87623669
131DNA replication-independent nucleosome assembly (GO:0006336)2.86558165
132DNA replication-independent nucleosome organization (GO:0034724)2.86558165
133cell fate commitment involved in formation of primary germ layer (GO:0060795)2.84571117
134establishment of viral latency (GO:0019043)2.84283639
135positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.82242810
136metaphase plate congression (GO:0051310)2.82215030
137dendrite morphogenesis (GO:0048813)2.81615682
138regulation of histone H3-K9 methylation (GO:0051570)2.81341118
139positive regulation of amine transport (GO:0051954)2.81294240
140membrane depolarization (GO:0051899)2.80775405
141synaptic transmission (GO:0007268)2.79105693
142positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.78896349
143calcium ion-dependent exocytosis (GO:0017156)2.77697216
144establishment or maintenance of bipolar cell polarity (GO:0061245)2.75280949
145establishment or maintenance of apical/basal cell polarity (GO:0035088)2.75280949
146ATP-dependent chromatin remodeling (GO:0043044)2.74906721
147telomere maintenance via semi-conservative replication (GO:0032201)2.74397454
148somatic hypermutation of immunoglobulin genes (GO:0016446)2.73839395
149somatic diversification of immune receptors via somatic mutation (GO:0002566)2.73839395
150neuron projection extension involved in neuron projection guidance (GO:1902284)2.73785219
151axon extension involved in axon guidance (GO:0048846)2.73785219
152regulation of chromosome segregation (GO:0051983)2.73762818
153positive regulation of chromosome segregation (GO:0051984)2.71654770
154histone exchange (GO:0043486)2.69942482
155regulation of RNA export from nucleus (GO:0046831)2.68893293
156regulation of cell fate specification (GO:0042659)2.68694120
157serine family amino acid biosynthetic process (GO:0009070)2.67089506
158DNA topological change (GO:0006265)2.66362909
159negative regulation of chromosome segregation (GO:0051985)2.65388725
160regulation of sister chromatid cohesion (GO:0007063)2.63967702
161homocysteine metabolic process (GO:0050667)2.63879588
162planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63872258
163protein localization to chromosome (GO:0034502)2.62821209
164protein-DNA complex disassembly (GO:0032986)2.60997843
165nucleosome disassembly (GO:0006337)2.60997843
166mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.60769855
167negative regulation of histone methylation (GO:0031061)2.59285959
168regulation of centriole replication (GO:0046599)2.58798874
169non-recombinational repair (GO:0000726)2.58788891
170double-strand break repair via nonhomologous end joining (GO:0006303)2.58788891
171histone arginine methylation (GO:0034969)2.58653655
172negative regulation of mitotic sister chromatid separation (GO:2000816)2.58250672
173negative regulation of sister chromatid segregation (GO:0033046)2.58250672
174negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.58250672
175negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.58250672
176negative regulation of mitotic sister chromatid segregation (GO:0033048)2.58250672
177regulation of nucleobase-containing compound transport (GO:0032239)2.57218518
178formation of translation preinitiation complex (GO:0001731)2.54631505
179negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.54288693
180DNA duplex unwinding (GO:0032508)2.53806461
181positive regulation of cell cycle G2/M phase transition (GO:1902751)2.53730773
182positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.53730773
183convergent extension (GO:0060026)2.53316789
184pyrimidine nucleobase catabolic process (GO:0006208)2.51137703
185regulation of fever generation (GO:0031620)2.48754318
186negative regulation of gene silencing (GO:0060969)2.48433867
187regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.47491437
188positive regulation of catenin import into nucleus (GO:0035413)2.47412019
189IMP biosynthetic process (GO:0006188)2.47350556
190positive regulation of dendritic spine morphogenesis (GO:0061003)2.46805336
191DNA geometric change (GO:0032392)2.45449033
192establishment of apical/basal cell polarity (GO:0035089)2.43106775
193myotube differentiation (GO:0014902)2.41898918
194chromatin assembly or disassembly (GO:0006333)2.41748159
195mitotic spindle checkpoint (GO:0071174)2.41347786
196mitotic nuclear envelope disassembly (GO:0007077)2.41333955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.29665904
2EZH2_22144423_ChIP-Seq_EOC_Human5.99764872
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.07751061
4GBX2_23144817_ChIP-Seq_PC3_Human3.89806544
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.65261204
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.05137650
7TAF15_26573619_Chip-Seq_HEK293_Human3.03274459
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.93998618
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84508053
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.84256087
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.84121047
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.84121047
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.84121047
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80123367
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78569061
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.56176831
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.51797319
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49594495
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.47071306
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45717672
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.44704288
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43638467
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.40324490
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.39973099
25EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37089773
26RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37089773
27REST_21632747_ChIP-Seq_MESCs_Mouse2.36365169
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34988711
29ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33772455
30JARID2_20075857_ChIP-Seq_MESCs_Mouse2.32948006
31MYC_19079543_ChIP-ChIP_MESCs_Mouse2.31269966
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29861277
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.26771589
34AR_21909140_ChIP-Seq_LNCAP_Human2.26540316
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25423210
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20288598
37MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16491455
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16183578
39IGF1R_20145208_ChIP-Seq_DFB_Human2.15126819
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.10019763
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06724617
42CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04314594
43BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00687492
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98896525
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97733545
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.97462028
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92571653
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.91152988
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90283649
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.89337937
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88690697
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87585679
53P300_19829295_ChIP-Seq_ESCs_Human1.87045364
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.86277469
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.85371690
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.85352268
57SOX2_16153702_ChIP-ChIP_HESCs_Human1.85124923
58* SMAD4_21799915_ChIP-Seq_A2780_Human1.84183684
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.83925541
60AR_21572438_ChIP-Seq_LNCaP_Human1.81447836
61ZNF263_19887448_ChIP-Seq_K562_Human1.78237304
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.76582456
63RNF2_27304074_Chip-Seq_NSC_Mouse1.70244220
64ZNF274_21170338_ChIP-Seq_K562_Hela1.70109850
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69803716
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67929684
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67105253
68DROSHA_22980978_ChIP-Seq_HELA_Human1.65900939
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.65865241
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63764160
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62082289
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.61586281
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.60551206
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59350021
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.57956870
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.56593557
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.55269609
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.54706320
79GATA1_26923725_Chip-Seq_HPCs_Mouse1.53356199
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52757476
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.51244280
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49174846
83MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48078228
84SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.47826014
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47504022
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46563220
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.46421969
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45870195
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43698561
90FUS_26573619_Chip-Seq_HEK293_Human1.43479335
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43069420
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42690492
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42564248
94ER_23166858_ChIP-Seq_MCF-7_Human1.42406487
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41891286
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41484172
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40659596
98KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40011880
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.39393079
100XRN2_22483619_ChIP-Seq_HELA_Human1.39334146
101AR_25329375_ChIP-Seq_VCAP_Human1.39174942
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.37104775
103RARB_27405468_Chip-Seq_BRAIN_Mouse1.37060884
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35504956
105NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35023015
106ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34905606
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33893244
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33268434
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32561564
110STAT3_23295773_ChIP-Seq_U87_Human1.31815772
111KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31250620
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30932503
113SOX2_21211035_ChIP-Seq_LN229_Gbm1.28911874
114FLI1_27457419_Chip-Seq_LIVER_Mouse1.27477015
115PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26724794
116POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.26221781
117NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.25990859
118TTF2_22483619_ChIP-Seq_HELA_Human1.24578792
119CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24564420
120* ERG_21242973_ChIP-ChIP_JURKAT_Human1.24419940
121TCF3_18692474_ChIP-Seq_MESCs_Mouse1.23931145
122* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23843623
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22140591
124MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21850125
125NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21559704
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21394729
127ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20445890
128KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20052928
129NANOG_18555785_Chip-Seq_ESCs_Mouse1.19891780
130EWS_26573619_Chip-Seq_HEK293_Human1.18894129
131E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18759463
132AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17515262
133* RUNX2_22187159_ChIP-Seq_PCA_Human1.17486268
134HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17333340
135POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17180575
136TCF4_23295773_ChIP-Seq_U87_Human1.15532677
137JUN_21703547_ChIP-Seq_K562_Human1.14203279
138POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13859963
139CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13709965
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13663227
141HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12054005
142CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.11557439
143SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11214540
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10080798
145SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08050170
146NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07868158
147WT1_19549856_ChIP-ChIP_CCG9911_Human1.06726779
148NANOG_21062744_ChIP-ChIP_HESCs_Human1.06709966
149RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06437148
150E2F1_18555785_Chip-Seq_ESCs_Mouse1.06239638
151RING1B_27294783_Chip-Seq_ESCs_Mouse1.06177774
152SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05143765
153PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04939269
154TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.03853849
155AR_19668381_ChIP-Seq_PC3_Human1.02280930
156TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02160433
157P53_22387025_ChIP-Seq_ESCs_Mouse1.01886517
158CMYC_18555785_Chip-Seq_ESCs_Mouse1.01825624
159SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00343308
160CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00207541
161TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99964198
162TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.99794946
163NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99218487
164DCP1A_22483619_ChIP-Seq_HELA_Human0.98608018
165SOX2_18692474_ChIP-Seq_MESCs_Mouse0.98348609
166P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98196018
167CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97901202
168ARNT_22903824_ChIP-Seq_MCF-7_Human0.97659309
169SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97496955
170ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96642424
171TP53_18474530_ChIP-ChIP_U2OS_Human0.95470660
172NFE2_27457419_Chip-Seq_LIVER_Mouse0.95327920
173KDM2B_26808549_Chip-Seq_REH_Human0.95178345
174TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95055694
175TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94834089
176ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94732865
177P300_18555785_Chip-Seq_ESCs_Mouse0.94086837
178TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93980282
179POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93980282
180CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93385070
181EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92609988
182EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90809399
183IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90732051
184CBP_20019798_ChIP-Seq_JUKART_Human0.90732051
185EZH2_27294783_Chip-Seq_NPCs_Mouse0.90533514
186MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89724853
187* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89182923
188PRDM14_20953172_ChIP-Seq_ESCs_Human0.88778562
189SOX9_26525672_Chip-Seq_HEART_Mouse0.88466624
190TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84551145
191PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84200549
192CLOCK_20551151_ChIP-Seq_293T_Human0.83436762
193NANOG_16518401_ChIP-PET_MESCs_Mouse0.83113518
194NANOG_18692474_ChIP-Seq_MEFs_Mouse0.81177733
195POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.80946834
196KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80815369
197SOX17_20123909_ChIP-Seq_XEN_Mouse0.80376923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.95744486
2MP0003122_maternal_imprinting4.27012887
3MP0004859_abnormal_synaptic_plasticity3.88465164
4MP0005645_abnormal_hypothalamus_physiol3.82414182
5MP0001968_abnormal_touch/_nociception3.35727409
6MP0006276_abnormal_autonomic_nervous3.33280337
7* MP0003635_abnormal_synaptic_transmissio3.31856540
8MP0009745_abnormal_behavioral_response3.26266680
9MP0009046_muscle_twitch3.26077783
10MP0005423_abnormal_somatic_nervous3.10698795
11MP0003693_abnormal_embryo_hatching2.96430921
12MP0002064_seizures2.94478585
13MP0004957_abnormal_blastocyst_morpholog2.76213449
14MP0002063_abnormal_learning/memory/cond2.64606964
15MP0002572_abnormal_emotion/affect_behav2.58541817
16MP0003111_abnormal_nucleus_morphology2.53736889
17MP0002735_abnormal_chemical_nociception2.47919978
18MP0003787_abnormal_imprinting2.46837027
19MP0005646_abnormal_pituitary_gland2.41425607
20MP0004233_abnormal_muscle_weight2.39080097
21MP0003136_yellow_coat_color2.38051511
22MP0002736_abnormal_nociception_after2.37448041
23MP0002272_abnormal_nervous_system2.31872766
24MP0001440_abnormal_grooming_behavior2.30816092
25MP0001501_abnormal_sleep_pattern2.25834158
26MP0003121_genomic_imprinting2.22835891
27MP0000537_abnormal_urethra_morphology2.22516671
28MP0001529_abnormal_vocalization2.21315216
29MP0010094_abnormal_chromosome_stability2.21245685
30MP0008932_abnormal_embryonic_tissue2.21107363
31MP0001486_abnormal_startle_reflex2.18713205
32MP0003941_abnormal_skin_development2.15287674
33MP0002734_abnormal_mechanical_nocicepti2.13292689
34MP0004142_abnormal_muscle_tone2.13131010
35MP0003123_paternal_imprinting2.10672679
36MP0004270_analgesia2.10296539
37MP0002067_abnormal_sensory_capabilities2.03803558
38MP0003718_maternal_effect2.00878348
39MP0001188_hyperpigmentation1.96298144
40MP0002733_abnormal_thermal_nociception1.88921062
41MP0003077_abnormal_cell_cycle1.87066111
42MP0002557_abnormal_social/conspecific_i1.84835335
43MP0003937_abnormal_limbs/digits/tail_de1.83505072
44MP0001970_abnormal_pain_threshold1.81141083
45MP0002184_abnormal_innervation1.80025217
46MP0001730_embryonic_growth_arrest1.79588500
47MP0008058_abnormal_DNA_repair1.75986173
48MP0009672_abnormal_birth_weight1.75462747
49MP0004924_abnormal_behavior1.72787766
50MP0005386_behavior/neurological_phenoty1.72787766
51MP0003119_abnormal_digestive_system1.72308325
52MP0000579_abnormal_nail_morphology1.64386530
53MP0000778_abnormal_nervous_system1.62836962
54MP0003890_abnormal_embryonic-extraembry1.58256586
55MP0001905_abnormal_dopamine_level1.57525922
56MP0002084_abnormal_developmental_patter1.56789725
57MP0002697_abnormal_eye_size1.56431460
58MP0001984_abnormal_olfaction1.55006411
59MP0002085_abnormal_embryonic_tissue1.54937731
60MP0008057_abnormal_DNA_replication1.54697629
61MP0001502_abnormal_circadian_rhythm1.49961069
62MP0003861_abnormal_nervous_system1.46243524
63MP0001293_anophthalmia1.45853363
64MP0001849_ear_inflammation1.44473306
65MP0010030_abnormal_orbit_morphology1.42190962
66MP0000428_abnormal_craniofacial_morphol1.39740839
67MP0009053_abnormal_anal_canal1.39024317
68MP0002876_abnormal_thyroid_physiology1.37005564
69MP0005380_embryogenesis_phenotype1.36949668
70MP0001672_abnormal_embryogenesis/_devel1.36949668
71MP0004197_abnormal_fetal_growth/weight/1.35558163
72MP0000350_abnormal_cell_proliferation1.31933129
73MP0000751_myopathy1.31742740
74MP0002877_abnormal_melanocyte_morpholog1.31623288
75MP0000049_abnormal_middle_ear1.30261436
76MP0002066_abnormal_motor_capabilities/c1.27620000
77MP0000631_abnormal_neuroendocrine_gland1.25245545
78MP0005076_abnormal_cell_differentiation1.24457238
79MP0001697_abnormal_embryo_size1.22898330
80MP0002653_abnormal_ependyma_morphology1.22344250
81MP0002080_prenatal_lethality1.20952359
82MP0000955_abnormal_spinal_cord1.19948164
83MP0004742_abnormal_vestibular_system1.19550400
84MP0002882_abnormal_neuron_morphology1.19084681
85MP0003984_embryonic_growth_retardation1.18544922
86MP0005187_abnormal_penis_morphology1.17390684
87MP0002909_abnormal_adrenal_gland1.17053549
88MP0010307_abnormal_tumor_latency1.15640008
89MP0009703_decreased_birth_body1.14823487
90MP0006072_abnormal_retinal_apoptosis1.14772340
91MP0003690_abnormal_glial_cell1.14621695
92MP0008569_lethality_at_weaning1.14295597
93MP0002088_abnormal_embryonic_growth/wei1.14251032
94MP0008877_abnormal_DNA_methylation1.13118839
95MP0004811_abnormal_neuron_physiology1.12660244
96MP0002233_abnormal_nose_morphology1.10366225
97MP0003705_abnormal_hypodermis_morpholog1.09880305
98MP0010352_gastrointestinal_tract_polyps1.09790052
99MP0004145_abnormal_muscle_electrophysio1.08768575
100MP0005551_abnormal_eye_electrophysiolog1.07930121
101MP0003935_abnormal_craniofacial_develop1.07298131
102MP0002837_dystrophic_cardiac_calcinosis1.04722149
103MP0000569_abnormal_digit_pigmentation1.03910006
104MP0004185_abnormal_adipocyte_glucose1.02646591
105MP0004858_abnormal_nervous_system1.02008987
106MP0000432_abnormal_head_morphology1.00481010
107MP0003315_abnormal_perineum_morphology1.00105188
108MP0008770_decreased_survivor_rate1.00039956
109MP0002111_abnormal_tail_morphology0.99438252
110MP0002163_abnormal_gland_morphology0.99274200
111MP0005379_endocrine/exocrine_gland_phen0.98876210
112MP0002069_abnormal_eating/drinking_beha0.98463141
113MP0002086_abnormal_extraembryonic_tissu0.98072178
114MP0003942_abnormal_urinary_system0.97054065
115MP0003385_abnormal_body_wall0.96898369
116MP0008007_abnormal_cellular_replicative0.94321985
117MP0001286_abnormal_eye_development0.94158117
118MP0002081_perinatal_lethality0.94040404
119MP0002249_abnormal_larynx_morphology0.94008978
120MP0000534_abnormal_ureter_morphology0.92194307
121MP0002822_catalepsy0.91850015
122MP0002092_abnormal_eye_morphology0.91477816
123MP0002152_abnormal_brain_morphology0.91341134
124MP0003755_abnormal_palate_morphology0.90981562
125MP0004147_increased_porphyrin_level0.90695503
126MP0003567_abnormal_fetal_cardiomyocyte0.87556448
127MP0002638_abnormal_pupillary_reflex0.86748891
128MP0004133_heterotaxia0.86410311
129MP0008872_abnormal_physiological_respon0.85964852
130MP0002229_neurodegeneration0.85933236
131MP0009780_abnormal_chondrocyte_physiolo0.85919148
132MP0001963_abnormal_hearing_physiology0.85584750
133MP0002752_abnormal_somatic_nervous0.85102916
134MP0003878_abnormal_ear_physiology0.84853546
135MP0005377_hearing/vestibular/ear_phenot0.84853546
136MP0006292_abnormal_olfactory_placode0.84271105
137MP0005171_absent_coat_pigmentation0.83831266
138MP0002254_reproductive_system_inflammat0.83594310
139MP0000467_abnormal_esophagus_morphology0.83314019
140MP0001177_atelectasis0.83237534
141MP0004085_abnormal_heartbeat0.80885463
142MP0002102_abnormal_ear_morphology0.80721634
143MP0005535_abnormal_body_temperature0.80511344
144MP0005253_abnormal_eye_physiology0.79859573
145MP0005501_abnormal_skin_physiology0.79580081
146MP0003115_abnormal_respiratory_system0.79564678
147MP0002116_abnormal_craniofacial_bone0.78613917
148MP0010368_abnormal_lymphatic_system0.77275366
149MP0000647_abnormal_sebaceous_gland0.77211351
150MP0003633_abnormal_nervous_system0.76867375
151MP0010386_abnormal_urinary_bladder0.75740272
152MP0000026_abnormal_inner_ear0.75390714
153MP0003137_abnormal_impulse_conducting0.74723135
154MP0002210_abnormal_sex_determination0.74669571
155MP0003634_abnormal_glial_cell0.74296578
156MP0004885_abnormal_endolymph0.73338109
157MP0005257_abnormal_intraocular_pressure0.73256625
158MP0001943_abnormal_respiration0.73156789
159MP0003879_abnormal_hair_cell0.72756349
160MP0005448_abnormal_energy_balance0.67897087
161MP0003959_abnormal_lean_body0.66802284
162MP0004215_abnormal_myocardial_fiber0.65557248
163MP0005394_taste/olfaction_phenotype0.64865733
164MP0005499_abnormal_olfactory_system0.64865733
165MP0003631_nervous_system_phenotype0.62808674
166MP0003283_abnormal_digestive_organ0.62210525
167MP0001664_abnormal_digestion0.61305609
168MP0001299_abnormal_eye_distance/0.61239619
169MP0005623_abnormal_meninges_morphology0.57148652
170MP0004272_abnormal_basement_membrane0.55919460
171MP0005409_darkened_coat_color0.54769003
172MP0000747_muscle_weakness0.54215758
173MP0003329_amyloid_beta_deposits0.53741557
174MP0002751_abnormal_autonomic_nervous0.53287382
175MP0008874_decreased_physiological_sensi0.52319020
176MP0002082_postnatal_lethality0.51914976
177MP0010770_preweaning_lethality0.51914976

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.07427167
2Focal seizures (HP:0007359)5.19270054
3Atonic seizures (HP:0010819)4.95167948
4Absence seizures (HP:0002121)4.94468996
5Visual hallucinations (HP:0002367)4.71883454
6Febrile seizures (HP:0002373)4.71820272
7Dialeptic seizures (HP:0011146)4.33915234
8Epileptic encephalopathy (HP:0200134)4.26236688
9Polyphagia (HP:0002591)4.17600368
10Generalized tonic-clonic seizures (HP:0002069)4.17528181
11Myokymia (HP:0002411)4.13198078
12Progressive inability to walk (HP:0002505)3.72170745
13Progressive cerebellar ataxia (HP:0002073)3.67848956
14Cortical dysplasia (HP:0002539)3.60126067
15Abnormal eating behavior (HP:0100738)3.57814835
16Increased nuchal translucency (HP:0010880)3.35979435
17Overriding aorta (HP:0002623)3.35608386
18Spastic diplegia (HP:0001264)3.35584686
19Abnormal hair whorl (HP:0010721)3.29227897
20Insomnia (HP:0100785)3.27842581
21Selective tooth agenesis (HP:0001592)3.26339639
22Failure to thrive in infancy (HP:0001531)3.24547535
23Broad-based gait (HP:0002136)3.17912374
24Agitation (HP:0000713)3.17130510
25Abnormal ciliary motility (HP:0012262)3.03221658
26Truncal ataxia (HP:0002078)3.01358443
27Abnormality of the labia minora (HP:0012880)3.00061067
28Hyperacusis (HP:0010780)2.95808247
29Mutism (HP:0002300)2.93426521
30Hyperventilation (HP:0002883)2.92267060
31Poor suck (HP:0002033)2.90860912
32Elfin facies (HP:0004428)2.88635024
33Limb dystonia (HP:0002451)2.88620369
34Drooling (HP:0002307)2.86841119
35Excessive salivation (HP:0003781)2.86841119
36Anxiety (HP:0000739)2.84856443
37Papilledema (HP:0001085)2.74292979
38Esophageal atresia (HP:0002032)2.73820002
39Split foot (HP:0001839)2.72591098
40Depression (HP:0000716)2.68890066
41Abnormality of the diencephalon (HP:0010662)2.68407546
42Hypothermia (HP:0002045)2.65146470
43Septo-optic dysplasia (HP:0100842)2.63506187
44Blue irides (HP:0000635)2.62988596
45Abnormal respiratory motile cilium physiology (HP:0012261)2.61439279
46Abnormality of midbrain morphology (HP:0002418)2.59788610
47Molar tooth sign on MRI (HP:0002419)2.59788610
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.59634551
49Hypoventilation (HP:0002791)2.59305085
50Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.57459852
51Esotropia (HP:0000565)2.54959223
52Narrow nasal bridge (HP:0000446)2.53441459
53Gait imbalance (HP:0002141)2.52430573
54Birth length less than 3rd percentile (HP:0003561)2.52031348
55Abnormal number of incisors (HP:0011064)2.51843618
56Menstrual irregularities (HP:0000858)2.49687886
57Sleep apnea (HP:0010535)2.48882373
58Oligomenorrhea (HP:0000876)2.46721929
59Psychosis (HP:0000709)2.45024679
60Renovascular hypertension (HP:0100817)2.43245271
61Aplasia/Hypoplasia of the sternum (HP:0006714)2.41749082
62Supranuclear gaze palsy (HP:0000605)2.38398979
63Acute necrotizing encephalopathy (HP:0006965)2.37565697
64Renal duplication (HP:0000075)2.37042979
65Dynein arm defect of respiratory motile cilia (HP:0012255)2.35488782
66Absent/shortened dynein arms (HP:0200106)2.35488782
67Aplasia involving bones of the extremities (HP:0009825)2.33413560
68Aplasia involving bones of the upper limbs (HP:0009823)2.33413560
69Aplasia of the phalanges of the hand (HP:0009802)2.33413560
70Inability to walk (HP:0002540)2.31888328
71Abnormal respiratory motile cilium morphology (HP:0005938)2.31867855
72Abnormal respiratory epithelium morphology (HP:0012253)2.31867855
73Poor eye contact (HP:0000817)2.31810666
74Ankle clonus (HP:0011448)2.30339099
75Cutaneous syndactyly (HP:0012725)2.30141883
76Dysdiadochokinesis (HP:0002075)2.29893105
77Generalized hypopigmentation of hair (HP:0011358)2.29666046
78Pheochromocytoma (HP:0002666)2.29419086
79Gaze-evoked nystagmus (HP:0000640)2.28594965
80Progressive macrocephaly (HP:0004481)2.27394319
81Generalized myoclonic seizures (HP:0002123)2.27122007
82Postural instability (HP:0002172)2.26820053
83Chromsome breakage (HP:0040012)2.25630872
84Specific learning disability (HP:0001328)2.25154416
85Duplication of thumb phalanx (HP:0009942)2.25011881
86Abnormal mitochondria in muscle tissue (HP:0008316)2.24904169
87Urethral obstruction (HP:0000796)2.20861011
88Ulnar bowing (HP:0003031)2.19939346
89Congenital primary aphakia (HP:0007707)2.19210714
90Status epilepticus (HP:0002133)2.17871212
91Fair hair (HP:0002286)2.17786449
92Obsessive-compulsive behavior (HP:0000722)2.17135562
93Abnormal EKG (HP:0003115)2.16929583
94Neuroendocrine neoplasm (HP:0100634)2.16385017
95Vertebral arch anomaly (HP:0008438)2.16318215
96Impaired vibration sensation in the lower limbs (HP:0002166)2.15793442
97Ankyloglossia (HP:0010296)2.15596503
98Medial flaring of the eyebrow (HP:0010747)2.15560936
99Fetal akinesia sequence (HP:0001989)2.15482124
100Turricephaly (HP:0000262)2.15096448
101Dysmetria (HP:0001310)2.13533919
102Gastrointestinal atresia (HP:0002589)2.13471780
103Protruding tongue (HP:0010808)2.12368289
104Ependymoma (HP:0002888)2.12151437
105Absent speech (HP:0001344)2.11466086
106Abnormal social behavior (HP:0012433)2.10765011
107Impaired social interactions (HP:0000735)2.10765011
108Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.10755570
109Abnormality of calcium-phosphate metabolism (HP:0100530)2.10063847
110Nephrogenic diabetes insipidus (HP:0009806)2.08797771
111Cutaneous finger syndactyly (HP:0010554)2.07470076
112Flat cornea (HP:0007720)2.07031718
113Ectopic kidney (HP:0000086)2.04829097
114Vertebral clefting (HP:0008428)2.04692453
115Epileptiform EEG discharges (HP:0011182)2.03396809
116Nephronophthisis (HP:0000090)2.02932333
117Abnormality of salivation (HP:0100755)2.02653819
118EEG with generalized epileptiform discharges (HP:0011198)2.02631473
119Choanal stenosis (HP:0000452)2.00477856
120Ankle contracture (HP:0006466)2.00048999
121Hepatoblastoma (HP:0002884)1.99658791
122Medulloblastoma (HP:0002885)1.99512324
123Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98595110
124Broad metatarsal (HP:0001783)1.97707940
125Bowel incontinence (HP:0002607)1.97363518
126Arnold-Chiari malformation (HP:0002308)1.96831643
127Bowel diverticulosis (HP:0005222)1.95818512
128Abnormality of the carotid arteries (HP:0005344)1.95480993
129Trigonocephaly (HP:0000243)1.95019976
130Hyperthyroidism (HP:0000836)1.94835429
131Back pain (HP:0003418)1.92993859
132Bradykinesia (HP:0002067)1.91499620
133Abnormal lung lobation (HP:0002101)1.91361352
134Shallow orbits (HP:0000586)1.91352803
135Tachypnea (HP:0002789)1.90752408
136Hip dysplasia (HP:0001385)1.89109469
137Hypoglycemic seizures (HP:0002173)1.88653570
138Scanning speech (HP:0002168)1.88645474
139Abnormality of homocysteine metabolism (HP:0010919)1.88317093
140Homocystinuria (HP:0002156)1.88317093
141Glioma (HP:0009733)1.88044378
142Abnormality of the corticospinal tract (HP:0002492)1.87256344
143Action tremor (HP:0002345)1.86923401
144Prolonged QT interval (HP:0001657)1.86068518
145Rhinitis (HP:0012384)1.86013887
146Hypsarrhythmia (HP:0002521)1.85958924
147Optic disc pallor (HP:0000543)1.85857610
148Open mouth (HP:0000194)1.85675556
149Abdominal situs inversus (HP:0003363)1.85222422
150Abnormality of abdominal situs (HP:0011620)1.85222422
151Abnormal large intestine physiology (HP:0012700)1.85204129
152Abnormality of the antihelix (HP:0009738)1.84754953
153Vaginal atresia (HP:0000148)1.83966578
154Hemiparesis (HP:0001269)1.83913913
155Nephroblastoma (Wilms tumor) (HP:0002667)1.83237057
156Genital tract atresia (HP:0001827)1.82846807
157Nasal speech (HP:0001611)1.82674074
158Truncus arteriosus (HP:0001660)1.82561749
159Patellar dislocation (HP:0002999)1.81653081
160Urinary bladder sphincter dysfunction (HP:0002839)1.80920985
161Partial duplication of thumb phalanx (HP:0009944)1.80524193
162Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80247384
163Generalized hypotonia (HP:0001290)1.80237542
164Bilateral microphthalmos (HP:0007633)1.80105547
165Myelomeningocele (HP:0002475)1.78714989
166Spinal rigidity (HP:0003306)1.77646247
167Gastrointestinal carcinoma (HP:0002672)1.77241794
168Malignant gastrointestinal tract tumors (HP:0006749)1.77241794
169Breast aplasia (HP:0100783)1.74342808
170Postnatal microcephaly (HP:0005484)1.73640291
171Abnormality of the astrocytes (HP:0100707)1.73475184
172Astrocytoma (HP:0009592)1.73475184
173Abnormality of the septum pellucidum (HP:0007375)1.72744542
174Abnormality of oral frenula (HP:0000190)1.71906180
175Aplasia/Hypoplasia of the breasts (HP:0010311)1.71700182
176Absent septum pellucidum (HP:0001331)1.70955509
177Absent radius (HP:0003974)1.69830168
178Short middle phalanx of the 5th finger (HP:0004220)1.69809168
179Proximal placement of thumb (HP:0009623)1.67610178
180Radioulnar synostosis (HP:0002974)1.67436885
181Embryonal renal neoplasm (HP:0011794)1.67158019
182Shoulder girdle muscle weakness (HP:0003547)1.66175494
183Attention deficit hyperactivity disorder (HP:0007018)1.65043744
184Biliary tract neoplasm (HP:0100574)1.64293985
185Small epiphyses (HP:0010585)1.63611131
186Neoplasm of the small intestine (HP:0100833)1.62508574
187Broad long bones (HP:0005622)1.62007868
188Omphalocele (HP:0001539)1.61803613
189Long palpebral fissure (HP:0000637)1.61721084
190Exercise-induced muscle cramps (HP:0003710)1.61559070
191Broad thumb (HP:0011304)1.60067939
192Facial cleft (HP:0002006)1.59006049
193Megalocornea (HP:0000485)1.58649263
194Broad distal phalanx of finger (HP:0009836)1.58140197
195Absent forearm bone (HP:0003953)1.58009268
196Aplasia involving forearm bones (HP:0009822)1.58009268
197Neoplasm of the rectum (HP:0100743)1.57438422
198Deviation of the thumb (HP:0009603)1.57045053

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.65329168
2CASK4.61554501
3MAP3K123.98457301
4CDC73.69815277
5MAP3K43.31276915
6NTRK23.22130999
7TTK3.21338398
8MARK13.18701744
9MAP2K73.15143072
10CDK123.12907048
11PBK2.66865630
12PNCK2.33085091
13ADRBK22.28023524
14MINK12.19838355
15TNIK2.15142286
16MAP2K42.14699564
17BUB12.11531631
18SRPK12.01627809
19GRK71.93482976
20MAP3K91.86303208
21WEE11.82305069
22TYRO31.79410862
23MAPK131.77800614
24MKNK11.76525792
25EEF2K1.67639681
26TNK21.63816718
27BRSK11.62799938
28BRD41.62688674
29EIF2AK11.59349306
30PLK41.54256393
31MKNK21.50161815
32NTRK11.50138673
33DYRK21.44586224
34PLK31.43437877
35UHMK11.43241073
36PLK11.41188447
37IRAK21.40198075
38EPHA41.37860662
39FES1.35762335
40EPHA31.34875152
41SMG11.33082835
42MUSK1.31736251
43SGK21.30355440
44SIK31.28214899
45PAK61.27371880
46KSR11.25708340
47SGK4941.24263533
48SGK2231.24263533
49MAP3K101.23706150
50CHEK21.22230341
51CAMK2A1.21506962
52PRPF4B1.18137925
53BCR1.17684105
54PRKCG1.17500547
55ICK1.17236070
56PAK31.17073184
57RIPK11.16764462
58CDK51.15258630
59ALK1.13156920
60SCYL21.13047099
61WNK31.12520712
62TAF11.08875630
63PHKG11.08179936
64PHKG21.08179936
65AKT31.04197408
66MAP3K81.02609592
67BRSK21.01901934
68PLK20.98391645
69CHEK10.97729250
70STK380.97004107
71PRKCH0.96277876
72LATS20.95450599
73TTN0.94855184
74NEK20.94614202
75PDGFRA0.93468408
76LATS10.93221597
77OXSR10.92497678
78FER0.92450772
79ARAF0.91041729
80MTOR0.89094361
81ATR0.87290369
82DYRK30.87036005
83CAMK1G0.84203292
84SIK20.82653778
85CDK190.82450689
86ATM0.81908029
87CAMK2B0.81873685
88GRK50.81521510
89STK30.80476387
90SGK30.79712356
91FGFR10.76684310
92PAK40.74582053
93NEK60.73680819
94STK390.72739890
95BMX0.72413852
96CDK10.71360023
97CAMK10.70911603
98TSSK60.70528322
99SGK10.70281326
100CAMK2G0.69981507
101PRKDC0.69633741
102NEK10.69121586
103CSNK1G20.68301609
104CDK20.67959180
105STK110.66999185
106PTK20.66406962
107MET0.66364322
108PRKCE0.65988192
109ROCK20.65569250
110ADRBK10.65102828
111PAK20.64385242
112CAMK2D0.64385154
113EPHB20.63639790
114CDK70.63544147
115ACVR1B0.63504133
116PKN10.63227367
117CDK180.62037740
118PRKD30.61812074
119AURKB0.61580616
120AURKA0.59967463
121CAMK1D0.59680025
122NME10.59242245
123PASK0.57930127
124CLK10.57703882
125CSNK1G10.56671404
126TRIM280.56201130
127CDK150.53936165
128ERBB30.53740471
129CDK140.53502277
130MST40.53385558
131DYRK1A0.51981369
132CDK30.51193455
133CAMKK20.50351137
134FGR0.48778521
135CAMKK10.48426766
136CSNK1G30.47675365
137GSK3B0.45407125
138LMTK20.44976073
139ZAK0.43671487
140PRKACA0.43634498
141PRKG10.43110327
142MAPK100.42723094
143CSNK1A1L0.42714229
144AKT20.42576296
145RPS6KA30.41738740
146MAPK140.41638245
147ERBB40.41491737
148RPS6KA20.41459528
149RAF10.41332634
150WNK10.40637588
151STK38L0.40264009
152CDK11A0.39991612
153ROCK10.38508829
154MAPKAPK50.37421789
155PRKD20.37123708
156RPS6KB10.36114754
157WNK40.34808607
158BRAF0.34323636
159PRKCB0.33528361
160CDC42BPA0.32630484
161PRKCA0.31773712
162YES10.30557354
163KSR20.29435860
164MAP3K10.29379005
165MYLK0.28025257
166PRKCZ0.27902832
167CSNK1E0.27311811
168MAPK150.26244417

Predicted pathways (KEGG)

RankGene SetZ-score
1* Nicotine addiction_Homo sapiens_hsa050335.01679904
2DNA replication_Homo sapiens_hsa030303.42969559
3* GABAergic synapse_Homo sapiens_hsa047273.42048282
4Synaptic vesicle cycle_Homo sapiens_hsa047213.13137164
5Mismatch repair_Homo sapiens_hsa034303.12612058
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.91899231
7* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.79140856
8* Morphine addiction_Homo sapiens_hsa050322.76257736
9Cell cycle_Homo sapiens_hsa041102.56636009
10Olfactory transduction_Homo sapiens_hsa047402.50753445
11Glutamatergic synapse_Homo sapiens_hsa047242.44080855
12Taste transduction_Homo sapiens_hsa047422.42370971
13RNA transport_Homo sapiens_hsa030132.41480854
14Circadian entrainment_Homo sapiens_hsa047132.31922533
15mRNA surveillance pathway_Homo sapiens_hsa030152.30105615
16Oxidative phosphorylation_Homo sapiens_hsa001902.20233621
17Collecting duct acid secretion_Homo sapiens_hsa049662.14978064
18* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.14586438
19Serotonergic synapse_Homo sapiens_hsa047262.14340010
20Amphetamine addiction_Homo sapiens_hsa050312.11250527
21Non-homologous end-joining_Homo sapiens_hsa034502.09606482
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08190340
23Spliceosome_Homo sapiens_hsa030402.06094261
24Vitamin B6 metabolism_Homo sapiens_hsa007502.03750958
25Base excision repair_Homo sapiens_hsa034102.03524489
26Cocaine addiction_Homo sapiens_hsa050301.92048752
27Long-term potentiation_Homo sapiens_hsa047201.89070548
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.85518448
29Dopaminergic synapse_Homo sapiens_hsa047281.80617738
30Insulin secretion_Homo sapiens_hsa049111.74692383
31Adherens junction_Homo sapiens_hsa045201.74127866
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71577887
33Biosynthesis of amino acids_Homo sapiens_hsa012301.71277330
34Salivary secretion_Homo sapiens_hsa049701.71265132
35Parkinsons disease_Homo sapiens_hsa050121.70344647
36Long-term depression_Homo sapiens_hsa047301.64804099
37Cardiac muscle contraction_Homo sapiens_hsa042601.60291371
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56976647
39Nucleotide excision repair_Homo sapiens_hsa034201.56974235
40Renin secretion_Homo sapiens_hsa049241.53069681
41One carbon pool by folate_Homo sapiens_hsa006701.50199344
42Hippo signaling pathway_Homo sapiens_hsa043901.50071685
43Cholinergic synapse_Homo sapiens_hsa047251.50036471
44Vibrio cholerae infection_Homo sapiens_hsa051101.49488315
45Gastric acid secretion_Homo sapiens_hsa049711.45926081
46Alzheimers disease_Homo sapiens_hsa050101.43905079
47Calcium signaling pathway_Homo sapiens_hsa040201.41077511
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40678240
49Basal transcription factors_Homo sapiens_hsa030221.39526749
50Fanconi anemia pathway_Homo sapiens_hsa034601.38482705
51Selenocompound metabolism_Homo sapiens_hsa004501.37597386
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36026695
53Steroid biosynthesis_Homo sapiens_hsa001001.30756398
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29989386
55Thyroid cancer_Homo sapiens_hsa052161.29962457
56Huntingtons disease_Homo sapiens_hsa050161.28584762
57MicroRNAs in cancer_Homo sapiens_hsa052061.28280130
58Basal cell carcinoma_Homo sapiens_hsa052171.25796457
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24080286
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23646427
61Central carbon metabolism in cancer_Homo sapiens_hsa052301.21306604
62Oxytocin signaling pathway_Homo sapiens_hsa049211.19978803
63Axon guidance_Homo sapiens_hsa043601.19495160
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.16412807
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15149455
66GnRH signaling pathway_Homo sapiens_hsa049121.15122313
67Folate biosynthesis_Homo sapiens_hsa007901.13282011
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13052569
69Type I diabetes mellitus_Homo sapiens_hsa049401.12853386
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12309879
71Homologous recombination_Homo sapiens_hsa034401.10861704
72RNA polymerase_Homo sapiens_hsa030201.09330596
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09036544
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07951099
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05934269
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01083725
77Melanogenesis_Homo sapiens_hsa049161.00523574
78cAMP signaling pathway_Homo sapiens_hsa040240.99623499
79Tight junction_Homo sapiens_hsa045300.99261800
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96166304
81Carbon metabolism_Homo sapiens_hsa012000.94284402
82RNA degradation_Homo sapiens_hsa030180.93629505
83Phototransduction_Homo sapiens_hsa047440.93533838
84Gap junction_Homo sapiens_hsa045400.93049960
85ErbB signaling pathway_Homo sapiens_hsa040120.90762509
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90504340
87Ovarian steroidogenesis_Homo sapiens_hsa049130.90288597
88Estrogen signaling pathway_Homo sapiens_hsa049150.90205701
89Lysine degradation_Homo sapiens_hsa003100.88872499
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88613004
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87916461
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86167750
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83489996
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83061378
95Type II diabetes mellitus_Homo sapiens_hsa049300.82337161
96Endometrial cancer_Homo sapiens_hsa052130.80691660
97Dilated cardiomyopathy_Homo sapiens_hsa054140.80182224
98p53 signaling pathway_Homo sapiens_hsa041150.79772842
99Colorectal cancer_Homo sapiens_hsa052100.79085420
100Butanoate metabolism_Homo sapiens_hsa006500.78077135
101Chronic myeloid leukemia_Homo sapiens_hsa052200.77207176
102Dorso-ventral axis formation_Homo sapiens_hsa043200.76935435
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76203163
104Prion diseases_Homo sapiens_hsa050200.73225718
105N-Glycan biosynthesis_Homo sapiens_hsa005100.72390918
106Pyruvate metabolism_Homo sapiens_hsa006200.72366656
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69801176
108Rheumatoid arthritis_Homo sapiens_hsa053230.69297481
109Proteoglycans in cancer_Homo sapiens_hsa052050.66844462
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66818429
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.65404237
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64791823
113Thyroid hormone synthesis_Homo sapiens_hsa049180.64622415
114Pyrimidine metabolism_Homo sapiens_hsa002400.62428593
115Ether lipid metabolism_Homo sapiens_hsa005650.61600417
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61538403
117Proteasome_Homo sapiens_hsa030500.61405743
118Melanoma_Homo sapiens_hsa052180.60215532
119Bladder cancer_Homo sapiens_hsa052190.59774684
120TGF-beta signaling pathway_Homo sapiens_hsa043500.59413014
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56456210
122MAPK signaling pathway_Homo sapiens_hsa040100.56412462
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55759366
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55474132
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.54766802
126Oocyte meiosis_Homo sapiens_hsa041140.54525631
127Rap1 signaling pathway_Homo sapiens_hsa040150.52371055
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51996394
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50954729
130Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50201061
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50196189
132Bile secretion_Homo sapiens_hsa049760.49783021
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49611497
134Choline metabolism in cancer_Homo sapiens_hsa052310.49572658
135Pathways in cancer_Homo sapiens_hsa052000.49142313
136ECM-receptor interaction_Homo sapiens_hsa045120.48934683
137Ras signaling pathway_Homo sapiens_hsa040140.47928213
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46798202
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.46700256
140Prostate cancer_Homo sapiens_hsa052150.46433640
141Pancreatic secretion_Homo sapiens_hsa049720.44354528
142Fatty acid elongation_Homo sapiens_hsa000620.43471823
143Purine metabolism_Homo sapiens_hsa002300.41933549
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41893259
145Alcoholism_Homo sapiens_hsa050340.41193541
146Renal cell carcinoma_Homo sapiens_hsa052110.39802124
147Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39595754
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39447471
149Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38829018
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38823748
151Hedgehog signaling pathway_Homo sapiens_hsa043400.38779779
152Glioma_Homo sapiens_hsa052140.38268125
153Pentose phosphate pathway_Homo sapiens_hsa000300.37362080
154Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37308059
155Notch signaling pathway_Homo sapiens_hsa043300.36859557
156AMPK signaling pathway_Homo sapiens_hsa041520.36386033
157Fatty acid biosynthesis_Homo sapiens_hsa000610.33990959
158Glucagon signaling pathway_Homo sapiens_hsa049220.33755252
159Phagosome_Homo sapiens_hsa041450.32683309
160Wnt signaling pathway_Homo sapiens_hsa043100.32457027
161Insulin signaling pathway_Homo sapiens_hsa049100.28270685
162Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26246807
163Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25700121
164Circadian rhythm_Homo sapiens_hsa047100.25346621
165Regulation of autophagy_Homo sapiens_hsa041400.23238853
166Arginine biosynthesis_Homo sapiens_hsa002200.23167775
167Inositol phosphate metabolism_Homo sapiens_hsa005620.22140346
168Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18917555
169Phenylalanine metabolism_Homo sapiens_hsa003600.18887659

Most similar genes based on co-expression Upload to Enrichr

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