GABRR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal rod cell development (GO:0046548)9.43347914
2G-protein coupled glutamate receptor signaling pathway (GO:0007216)7.49410425
3relaxation of smooth muscle (GO:0044557)7.45571482
4cellular potassium ion homeostasis (GO:0030007)7.34804270
5sodium ion export (GO:0071436)7.02617615
6response to pheromone (GO:0019236)6.73733975
7protein K11-linked deubiquitination (GO:0035871)6.62503081
8potassium ion homeostasis (GO:0055075)6.48125424
9positive regulation of synapse maturation (GO:0090129)6.27038163
10retinal cone cell development (GO:0046549)6.10418513
11synaptic vesicle exocytosis (GO:0016079)5.98419252
12synaptic vesicle endocytosis (GO:0048488)5.64453968
13cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.40835256
14protein localization to cilium (GO:0061512)5.40085185
15protein localization to synapse (GO:0035418)5.05354669
16photoreceptor cell development (GO:0042461)5.01476740
17eye photoreceptor cell development (GO:0042462)5.01339347
18regulation of synapse maturation (GO:0090128)4.91393533
19potassium ion export (GO:0071435)4.83167262
20rhodopsin mediated signaling pathway (GO:0016056)4.77305078
21regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.68256497
22innervation (GO:0060384)4.65581331
23photoreceptor cell maintenance (GO:0045494)4.61037005
24cell communication by electrical coupling (GO:0010644)4.54093096
25single strand break repair (GO:0000012)4.49193561
26cellular sodium ion homeostasis (GO:0006883)4.48952918
27urinary tract smooth muscle contraction (GO:0014848)4.45587750
28striatum development (GO:0021756)4.28274791
29peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.22702865
30serotonin receptor signaling pathway (GO:0007210)4.15634936
31neural tube formation (GO:0001841)4.14031853
32positive regulation of dendritic spine morphogenesis (GO:0061003)4.12931776
33short-term memory (GO:0007614)4.11631952
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.04335243
35regulation of synaptic vesicle exocytosis (GO:2000300)4.01024083
36* gamma-aminobutyric acid signaling pathway (GO:0007214)4.00297326
37calcium ion import (GO:0070509)3.98550492
38mating behavior (GO:0007617)3.95185418
39establishment of synaptic vesicle localization (GO:0097480)3.94385237
40synaptic vesicle transport (GO:0048489)3.94385237
41regulation of action potential (GO:0098900)3.91657542
42atrial cardiac muscle cell action potential (GO:0086014)3.91491829
43regulation of short-term neuronal synaptic plasticity (GO:0048172)3.90757832
44lymphangiogenesis (GO:0001946)3.90621847
45pyrimidine dimer repair (GO:0006290)3.84947229
46sensory perception of light stimulus (GO:0050953)3.80509540
47protein-chromophore linkage (GO:0018298)3.77021799
48neurotransmitter-gated ion channel clustering (GO:0072578)3.75090627
49visual perception (GO:0007601)3.74710819
50membrane hyperpolarization (GO:0060081)3.70770352
51iron coordination entity transport (GO:1901678)3.70498917
52positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.60043751
53pyrimidine nucleobase catabolic process (GO:0006208)3.59806677
54regulation of rhodopsin mediated signaling pathway (GO:0022400)3.59519821
55axon cargo transport (GO:0008088)3.58627400
56positive regulation of gastrulation (GO:2000543)3.58031547
57synaptic vesicle maturation (GO:0016188)3.56384991
58anterograde axon cargo transport (GO:0008089)3.53480752
59neurofilament cytoskeleton organization (GO:0060052)3.52369073
60regulation of bile acid biosynthetic process (GO:0070857)3.49207606
61startle response (GO:0001964)3.48816104
62regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.46228375
63regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.46228375
64positive regulation of action potential (GO:0045760)3.45384104
65lactate metabolic process (GO:0006089)3.44549164
66nitric oxide mediated signal transduction (GO:0007263)3.41583620
67DNA integration (GO:0015074)3.40694306
68glycolytic process (GO:0006096)3.40092726
69glutamate receptor signaling pathway (GO:0007215)3.39150821
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.38511082
71membrane depolarization during action potential (GO:0086010)3.36951110
72detection of visible light (GO:0009584)3.35273604
73substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.34203203
74substrate-independent telencephalic tangential migration (GO:0021826)3.34203203
75neuronal action potential propagation (GO:0019227)3.32283417
76cilium or flagellum-dependent cell motility (GO:0001539)3.32244405
77dendritic spine morphogenesis (GO:0060997)3.31858326
78negative regulation of mast cell activation (GO:0033004)3.31418933
79nonmotile primary cilium assembly (GO:0035058)3.30444539
80regulation of appetite (GO:0032098)3.30205650
81response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.27472122
82response to host (GO:0075136)3.27472122
83response to host defenses (GO:0052200)3.27472122
84detection of light stimulus (GO:0009583)3.26267791
85limb bud formation (GO:0060174)3.24940882
86DNA damage response, detection of DNA damage (GO:0042769)3.24658210
87response to host immune response (GO:0052572)3.24555623
88response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.24555623
89regulation of synaptic vesicle transport (GO:1902803)3.23637870
90behavioral response to nicotine (GO:0035095)3.22171260
91behavioral response to ethanol (GO:0048149)3.19885701
92membrane repolarization (GO:0086009)3.16010681
93apical protein localization (GO:0045176)3.14294226
94reflex (GO:0060004)3.13605898
95kidney morphogenesis (GO:0060993)3.09695610
96retina development in camera-type eye (GO:0060041)3.09078287
97thyroid hormone metabolic process (GO:0042403)3.08487888
98presynaptic membrane assembly (GO:0097105)3.07678830
99prepulse inhibition (GO:0060134)3.07283651
100sperm motility (GO:0030317)3.05418970
101detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.05382696
102detection of temperature stimulus involved in sensory perception (GO:0050961)3.05382696
103response to histamine (GO:0034776)3.04934731
104glycerophospholipid catabolic process (GO:0046475)3.04143777
105regulation of voltage-gated calcium channel activity (GO:1901385)3.03696426
106synapse assembly (GO:0007416)3.03660004
107regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.03300387
108DNA double-strand break processing (GO:0000729)3.02137057
109neuron recognition (GO:0008038)3.01697653
110detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.01159487
111hematopoietic stem cell proliferation (GO:0071425)3.00518925
112retinal ganglion cell axon guidance (GO:0031290)2.96731348
113potassium ion transmembrane transport (GO:0071805)2.96478449
114cellular potassium ion transport (GO:0071804)2.96478449
115regulation of neurotransmitter secretion (GO:0046928)2.96168874
116regulation of synapse structural plasticity (GO:0051823)2.95985164
117cilium morphogenesis (GO:0060271)2.95258469
118positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.95062101
119protein polyglutamylation (GO:0018095)2.93938975
120regulation of synaptic transmission, glutamatergic (GO:0051966)2.93770310
121microtubule polymerization or depolymerization (GO:0031109)2.93558639
122homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.92624207
123C4-dicarboxylate transport (GO:0015740)2.92137582
124positive regulation of cGMP biosynthetic process (GO:0030828)2.91915941
125vocalization behavior (GO:0071625)2.91814419
126regulation of neurotransmitter transport (GO:0051588)2.91478906
127central nervous system projection neuron axonogenesis (GO:0021952)2.91203458
128cellular response to light stimulus (GO:0071482)2.91137721
129cGMP biosynthetic process (GO:0006182)2.90677914
130positive regulation of potassium ion transmembrane transport (GO:1901381)2.90526712
131establishment of protein localization to Golgi (GO:0072600)2.89862371
132regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.89653465
133response to acidic pH (GO:0010447)2.89068246
134limb development (GO:0060173)2.88545238
135appendage development (GO:0048736)2.88545238
136microtubule severing (GO:0051013)2.87286754
137phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.87186378
138negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86665202
139neuronal action potential (GO:0019228)2.82933427
140negative regulation of calcium ion transport into cytosol (GO:0010523)2.81576408
141protein K48-linked deubiquitination (GO:0071108)2.80553042
142cornea development in camera-type eye (GO:0061303)2.78479762
143transmission of nerve impulse (GO:0019226)2.77392992
144axonal fasciculation (GO:0007413)2.76000399
145protein-cofactor linkage (GO:0018065)2.74618208
146protein K63-linked deubiquitination (GO:0070536)2.73240286
147acrosome reaction (GO:0007340)2.73188669
148presynaptic membrane organization (GO:0097090)2.72927817
149nucleobase catabolic process (GO:0046113)2.70564816
150neuromuscular process controlling posture (GO:0050884)2.70485319
151regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.69758714
152regulation of cAMP-dependent protein kinase activity (GO:2000479)2.67976579
153positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.66541088
154epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63670255
155RNA localization (GO:0006403)2.63414562
156regulation of helicase activity (GO:0051095)2.63226957
157mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.63183818
158protein sumoylation (GO:0016925)2.63052414
159regulation of Rac GTPase activity (GO:0032314)2.61392714
160head development (GO:0060322)2.60967784
161glial cell proliferation (GO:0014009)2.58722665
162negative regulation of circadian rhythm (GO:0042754)2.58497819
163sympathetic nervous system development (GO:0048485)2.58024446
164cysteine metabolic process (GO:0006534)2.56943527
165negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.55553687
166regulation of protein kinase A signaling (GO:0010738)2.54986963
167neuron fate determination (GO:0048664)2.54490829
168positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.53658090
169interferon-gamma production (GO:0032609)2.53432375
170central nervous system neuron axonogenesis (GO:0021955)2.52839173
171indole-containing compound catabolic process (GO:0042436)2.50945463
172indolalkylamine catabolic process (GO:0046218)2.50945463
173tryptophan catabolic process (GO:0006569)2.50945463
174spinal cord development (GO:0021510)2.48584048
175sex differentiation (GO:0007548)2.47615640
176rRNA catabolic process (GO:0016075)2.47390478
177synaptic transmission, glutamatergic (GO:0035249)2.47304917
178cardiac right ventricle morphogenesis (GO:0003215)2.47260057
179righting reflex (GO:0060013)2.47114995
180neuron cell-cell adhesion (GO:0007158)2.45867025
181regulation of Cdc42 GTPase activity (GO:0043088)2.45715340
182artery development (GO:0060840)2.45282363
183central nervous system myelination (GO:0022010)2.44511287
184axon ensheathment in central nervous system (GO:0032291)2.44511287
185peripheral nervous system neuron development (GO:0048935)2.44250547
186detection of light stimulus involved in sensory perception (GO:0050962)11.6038608
187detection of light stimulus involved in visual perception (GO:0050908)11.6038608
188negative regulation of cytosolic calcium ion concentration (GO:0051481)10.2139860

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.95398408
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.83742237
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.58789458
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.50009194
5ZNF274_21170338_ChIP-Seq_K562_Hela2.69815247
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.67702940
7DROSHA_22980978_ChIP-Seq_HELA_Human2.66895597
8REST_21632747_ChIP-Seq_MESCs_Mouse2.66605662
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52667206
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.52651812
11* EZH2_27294783_Chip-Seq_ESCs_Mouse2.44761410
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.43136948
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43104324
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.41502164
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37409168
16P53_22127205_ChIP-Seq_FIBROBLAST_Human2.36649359
17AR_21572438_ChIP-Seq_LNCaP_Human2.36494190
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29690305
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26937992
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26347601
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.23944165
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.19748753
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.17084918
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11728401
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.11615100
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07403265
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.02728376
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00914066
29EWS_26573619_Chip-Seq_HEK293_Human1.99370776
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98812861
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.96990458
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.96990458
33VDR_22108803_ChIP-Seq_LS180_Human1.96913142
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93402611
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.92328392
36POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.87778445
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87778445
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87360088
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83163312
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74907390
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73252399
42FUS_26573619_Chip-Seq_HEK293_Human1.72435552
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.72115467
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71134619
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69920951
46SMAD4_21799915_ChIP-Seq_A2780_Human1.68736875
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67656792
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.66853076
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59677893
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.58273643
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.58066851
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57854480
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56521116
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.52372995
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49740784
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.46981024
57TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.45731886
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.45494533
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44400167
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.43133840
61TP53_22573176_ChIP-Seq_HFKS_Human1.41769892
62* AR_25329375_ChIP-Seq_VCAP_Human1.41372917
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.41141417
64RNF2_27304074_Chip-Seq_NSC_Mouse1.39299865
65TAF15_26573619_Chip-Seq_HEK293_Human1.39296040
66RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38625943
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35717178
68AR_19668381_ChIP-Seq_PC3_Human1.34885494
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34489981
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.33430493
71SMAD3_21741376_ChIP-Seq_HESCs_Human1.33411006
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.31779891
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31475377
74IGF1R_20145208_ChIP-Seq_DFB_Human1.31187833
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30608177
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30050947
77P300_19829295_ChIP-Seq_ESCs_Human1.29001889
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28436130
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27588993
80ELK4_26923725_Chip-Seq_MESODERM_Mouse1.27372543
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24709730
82CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.24659115
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24555765
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23262496
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.22896036
86EZH2_22144423_ChIP-Seq_EOC_Human1.22499220
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.21686226
88MYC_18940864_ChIP-ChIP_HL60_Human1.20125247
89STAT3_23295773_ChIP-Seq_U87_Human1.19374025
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19048883
91CBP_20019798_ChIP-Seq_JUKART_Human1.19048883
92BCAT_22108803_ChIP-Seq_LS180_Human1.18526722
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17783740
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17589947
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15581517
96TCF4_23295773_ChIP-Seq_U87_Human1.15394257
97SMAD4_21741376_ChIP-Seq_HESCs_Human1.14675404
98RUNX2_22187159_ChIP-Seq_PCA_Human1.13487199
99SOX9_26525672_Chip-Seq_HEART_Mouse1.13473301
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13248166
101YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12294321
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10478960
103SOX2_21211035_ChIP-Seq_LN229_Gbm1.10064504
104RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09456480
105ER_23166858_ChIP-Seq_MCF-7_Human1.09399276
106KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09269928
107NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.08893712
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.08379103
109SMAD3_21741376_ChIP-Seq_ESCs_Human1.07674359
110ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07303734
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07180407
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06958767
113NANOG_19829295_ChIP-Seq_ESCs_Human1.05891758
114SOX2_19829295_ChIP-Seq_ESCs_Human1.05891758
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05337889
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04873959
117CTCF_27219007_Chip-Seq_Bcells_Human1.04254751
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02215312
119EZH2_27294783_Chip-Seq_NPCs_Mouse1.01910002
120TCF4_22108803_ChIP-Seq_LS180_Human1.01897667
121OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01670881
122JUN_21703547_ChIP-Seq_K562_Human1.01312550
123SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00784646
124TAL1_26923725_Chip-Seq_HPCs_Mouse1.00291525
125RING1B_27294783_Chip-Seq_NPCs_Mouse0.99120551
126CBP_21632823_ChIP-Seq_H3396_Human0.98520456
127WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98259941
128TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97641729
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97573144
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97398646
131CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96599310
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95909152
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95603956
134P53_22387025_ChIP-Seq_ESCs_Mouse0.95495710
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93811159
136HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93686605
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91248790
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90432804
139DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88440803
140WDR5_24793694_ChIP-Seq_LNCAP_Human0.87235011

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog7.02571697
2MP0006072_abnormal_retinal_apoptosis5.27150754
3MP0002090_abnormal_vision5.26834906
4MP0005253_abnormal_eye_physiology3.77376710
5MP0002102_abnormal_ear_morphology3.55054626
6MP0003950_abnormal_plasma_membrane3.53286424
7MP0003011_delayed_dark_adaptation3.20824256
8MP0001502_abnormal_circadian_rhythm3.17919189
9MP0006292_abnormal_olfactory_placode3.14187740
10MP0005195_abnormal_posterior_eye2.86888589
11MP0004233_abnormal_muscle_weight2.70130100
12MP0001346_abnormal_lacrimal_gland2.62821658
13MP0005248_abnormal_Harderian_gland2.62799178
14MP0003880_abnormal_central_pattern2.57823883
15MP0002638_abnormal_pupillary_reflex2.57470324
16MP0004782_abnormal_surfactant_physiolog2.56987245
17MP0006276_abnormal_autonomic_nervous2.53572890
18MP0010386_abnormal_urinary_bladder2.26730013
19MP0003878_abnormal_ear_physiology2.20207901
20MP0005377_hearing/vestibular/ear_phenot2.20207901
21* MP0001984_abnormal_olfaction2.15231109
22MP0008775_abnormal_heart_ventricle2.10810079
23MP0003183_abnormal_peptide_metabolism2.05476416
24MP0004084_abnormal_cardiac_muscle2.05107278
25MP0005670_abnormal_white_adipose2.05042531
26MP0001188_hyperpigmentation1.96460572
27MP0008877_abnormal_DNA_methylation1.95986580
28MP0002735_abnormal_chemical_nociception1.94368145
29MP0005645_abnormal_hypothalamus_physiol1.92895595
30MP0001324_abnormal_eye_pigmentation1.89126577
31MP0005423_abnormal_somatic_nervous1.87561694
32MP0004215_abnormal_myocardial_fiber1.86815622
33MP0004036_abnormal_muscle_relaxation1.86661765
34MP0001485_abnormal_pinna_reflex1.83836514
35MP0001486_abnormal_startle_reflex1.83243955
36MP0002229_neurodegeneration1.80563138
37MP0005187_abnormal_penis_morphology1.75393427
38MP0005391_vision/eye_phenotype1.73375192
39MP0005394_taste/olfaction_phenotype1.73267401
40MP0005499_abnormal_olfactory_system1.73267401
41MP0003635_abnormal_synaptic_transmissio1.71197769
42MP0001986_abnormal_taste_sensitivity1.67114335
43MP0002752_abnormal_somatic_nervous1.66938107
44MP0008789_abnormal_olfactory_epithelium1.64922786
45MP0004133_heterotaxia1.59094542
46MP0009046_muscle_twitch1.50223179
47MP0008875_abnormal_xenobiotic_pharmacok1.49498941
48MP0002067_abnormal_sensory_capabilities1.48071928
49MP0002184_abnormal_innervation1.47163119
50MP0008057_abnormal_DNA_replication1.46644189
51MP0010030_abnormal_orbit_morphology1.46166079
52MP0002064_seizures1.45684188
53MP0005595_abnormal_vascular_smooth1.43364734
54MP0000631_abnormal_neuroendocrine_gland1.42928282
55MP0002332_abnormal_exercise_endurance1.42687745
56MP0002909_abnormal_adrenal_gland1.40318127
57MP0002063_abnormal_learning/memory/cond1.39005747
58MP0003122_maternal_imprinting1.38296750
59MP0010368_abnormal_lymphatic_system1.36366572
60* MP0002272_abnormal_nervous_system1.31243287
61MP0002882_abnormal_neuron_morphology1.29093087
62MP0005410_abnormal_fertilization1.25861033
63MP0001968_abnormal_touch/_nociception1.21978159
64MP0001529_abnormal_vocalization1.21601669
65MP0009745_abnormal_behavioral_response1.20855116
66MP0008004_abnormal_stomach_pH1.20840834
67MP0004043_abnormal_pH_regulation1.20466183
68MP0002234_abnormal_pharynx_morphology1.18993725
69MP0004145_abnormal_muscle_electrophysio1.18854358
70MP0003221_abnormal_cardiomyocyte_apopto1.18590543
71MP0003567_abnormal_fetal_cardiomyocyte1.18209739
72MP0003879_abnormal_hair_cell1.15727556
73MP0000647_abnormal_sebaceous_gland1.15707013
74MP0002138_abnormal_hepatobiliary_system1.15081165
75MP0008569_lethality_at_weaning1.13903936
76MP0004859_abnormal_synaptic_plasticity1.08720630
77MP0000049_abnormal_middle_ear1.06457548
78MP0000026_abnormal_inner_ear1.06409007
79MP0004142_abnormal_muscle_tone1.05078868
80MP0002928_abnormal_bile_duct1.03575271
81MP0003646_muscle_fatigue1.03347651
82MP0002822_catalepsy0.99346436
83* MP0001970_abnormal_pain_threshold0.99068955
84MP0008058_abnormal_DNA_repair0.98613397
85MP0002572_abnormal_emotion/affect_behav0.97637430
86MP0009697_abnormal_copulation0.96315956
87MP0006035_abnormal_mitochondrial_morpho0.96277446
88MP0003137_abnormal_impulse_conducting0.95925213
89MP0003861_abnormal_nervous_system0.95492689
90MP0004742_abnormal_vestibular_system0.94030055
91MP0003718_maternal_effect0.93794611
92MP0002160_abnormal_reproductive_system0.89788510
93MP0000534_abnormal_ureter_morphology0.89591450
94MP0003868_abnormal_feces_composition0.89262122
95MP0005220_abnormal_exocrine_pancreas0.88155624
96MP0005310_abnormal_salivary_gland0.87021930
97MP0002210_abnormal_sex_determination0.86746113
98MP0001286_abnormal_eye_development0.86264874
99MP0003121_genomic_imprinting0.85915756
100MP0005389_reproductive_system_phenotype0.83703081
101MP0000955_abnormal_spinal_cord0.83507068
102MP0001929_abnormal_gametogenesis0.83128492
103MP0005620_abnormal_muscle_contractility0.82644984
104MP0003787_abnormal_imprinting0.81102148
105MP0003634_abnormal_glial_cell0.80900539
106MP0001764_abnormal_homeostasis0.80329375
107MP0003315_abnormal_perineum_morphology0.80192556
108MP0002653_abnormal_ependyma_morphology0.80072614
109MP0005646_abnormal_pituitary_gland0.79738164
110MP0002837_dystrophic_cardiac_calcinosis0.79396806
111MP0003938_abnormal_ear_development0.79288171
112MP0003385_abnormal_body_wall0.79042850
113MP0005367_renal/urinary_system_phenotyp0.78196588
114MP0000516_abnormal_urinary_system0.78196588
115MP0001501_abnormal_sleep_pattern0.77692573
116MP0004924_abnormal_behavior0.74860465
117MP0005386_behavior/neurological_phenoty0.74860465
118MP0003890_abnormal_embryonic-extraembry0.73412555
119MP0000751_myopathy0.73318782
120MP0002736_abnormal_nociception_after0.73023856
121MP0004811_abnormal_neuron_physiology0.72480379
122MP0004885_abnormal_endolymph0.71689251
123MP0004270_analgesia0.69250704
124MP0002557_abnormal_social/conspecific_i0.65374742
125MP0004085_abnormal_heartbeat0.65137664
126MP0003172_abnormal_lysosome_physiology0.65096574
127MP0002697_abnormal_eye_size0.64256124
128MP0003633_abnormal_nervous_system0.63960892
129MP0002069_abnormal_eating/drinking_beha0.59703872
130MP0002066_abnormal_motor_capabilities/c0.59666148
131* MP0002734_abnormal_mechanical_nocicepti0.59307507
132MP0002152_abnormal_brain_morphology0.58359054
133MP0002277_abnormal_respiratory_mucosa0.56867013
134MP0001963_abnormal_hearing_physiology0.56130520
135MP0001177_atelectasis0.55235277
136MP0000230_abnormal_systemic_arterial0.54534167
137MP0002751_abnormal_autonomic_nervous0.53312831
138MP0008961_abnormal_basal_metabolism0.52066301
139MP0000749_muscle_degeneration0.51697836
140MP0000778_abnormal_nervous_system0.51332896
141MP0005365_abnormal_bile_salt0.51274501
142MP0002127_abnormal_cardiovascular_syste0.49377232
143MP0003698_abnormal_male_reproductive0.48403086
144MP0008872_abnormal_physiological_respon0.47363895

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)8.23834149
2Abnormality of macular pigmentation (HP:0008002)7.66596705
3Severe visual impairment (HP:0001141)6.97445687
4Abnormal rod and cone electroretinograms (HP:0008323)6.33384301
5Decreased central vision (HP:0007663)6.09040182
6Scotoma (HP:0000575)5.76065166
7Bony spicule pigmentary retinopathy (HP:0007737)5.75819266
8Septo-optic dysplasia (HP:0100842)5.49660611
9Increased corneal curvature (HP:0100692)5.11138244
10Keratoconus (HP:0000563)5.11138244
11Epileptic encephalopathy (HP:0200134)4.86046655
12Abnormal gallbladder physiology (HP:0012438)4.29690089
13Cholecystitis (HP:0001082)4.29690089
14Febrile seizures (HP:0002373)4.23024819
15Hypoplasia of the fovea (HP:0007750)4.04956758
16Aplasia/Hypoplasia of the fovea (HP:0008060)4.04956758
17Attenuation of retinal blood vessels (HP:0007843)3.99877058
18Albinism (HP:0001022)3.93723895
19Absence seizures (HP:0002121)3.81889591
20True hermaphroditism (HP:0010459)3.68099828
21Abnormal pupillary function (HP:0007686)3.64387873
22Pancreatic cysts (HP:0001737)3.58569685
23Pancreatic fibrosis (HP:0100732)3.37058030
24Abnormality of the labia minora (HP:0012880)3.35544270
25Molar tooth sign on MRI (HP:0002419)3.34487646
26Abnormality of midbrain morphology (HP:0002418)3.34487646
27Abnormality of the fovea (HP:0000493)3.32462122
28Progressive cerebellar ataxia (HP:0002073)3.27252910
29Pendular nystagmus (HP:0012043)3.20457923
30Congenital sensorineural hearing impairment (HP:0008527)3.15125434
31Nephronophthisis (HP:0000090)3.01048680
32Hemiparesis (HP:0001269)2.99692558
33Dialeptic seizures (HP:0011146)2.94526013
34Abolished electroretinogram (ERG) (HP:0000550)2.92134732
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.89705018
36Type II lissencephaly (HP:0007260)2.88600910
37Lissencephaly (HP:0001339)2.88502108
38Hyperglycinemia (HP:0002154)2.86552966
39Retinal dysplasia (HP:0007973)2.84737816
40Aplasia/Hypoplasia of the macula (HP:0008059)2.82743942
41Prolonged QT interval (HP:0001657)2.82634408
42Absent septum pellucidum (HP:0001331)2.80149013
43Optic nerve hypoplasia (HP:0000609)2.74596886
44Broad-based gait (HP:0002136)2.74208190
45Dyschromatopsia (HP:0007641)2.71815901
46Photophobia (HP:0000613)2.69246250
47Sclerocornea (HP:0000647)2.66394988
48Bicornuate uterus (HP:0000813)2.65918234
49Severe Myopia (HP:0011003)2.65143562
50Aplasia/Hypoplasia affecting the retina (HP:0008061)2.64228308
51Chorioretinal atrophy (HP:0000533)2.62454956
52Chronic hepatic failure (HP:0100626)2.57258089
53Genital tract atresia (HP:0001827)2.54960770
54Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.51846137
55Abnormality of the renal medulla (HP:0100957)2.50686756
56Vaginal atresia (HP:0000148)2.50484402
57Anophthalmia (HP:0000528)2.49312652
58Colon cancer (HP:0003003)2.47674106
59Decreased circulating renin level (HP:0003351)2.46920651
60Type II diabetes mellitus (HP:0005978)2.44648097
61Abdominal situs inversus (HP:0003363)2.42730137
62Abnormality of abdominal situs (HP:0011620)2.42730137
63Hyperventilation (HP:0002883)2.42483253
64Abnormality of the septum pellucidum (HP:0007375)2.40416474
65Retinitis pigmentosa (HP:0000510)2.37517605
66Pigmentary retinal degeneration (HP:0001146)2.36819552
67Dysdiadochokinesis (HP:0002075)2.36790604
68Stenosis of the external auditory canal (HP:0000402)2.30741677
69Cystic liver disease (HP:0006706)2.30379536
70EEG with generalized epileptiform discharges (HP:0011198)2.30331769
71Fetal akinesia sequence (HP:0001989)2.29459265
72Abnormal lung lobation (HP:0002101)2.25767991
73Flat cornea (HP:0007720)2.25486328
74Generalized hypopigmentation (HP:0007513)2.25103011
75Male pseudohermaphroditism (HP:0000037)2.23725081
76Anencephaly (HP:0002323)2.23409601
77Epileptiform EEG discharges (HP:0011182)2.20425798
78Abnormality of the renal cortex (HP:0011035)2.16234590
79Focal seizures (HP:0007359)2.15145196
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14114006
81Tubular atrophy (HP:0000092)2.11966039
82Hip dysplasia (HP:0001385)2.09234391
83Cone-rod dystrophy (HP:0000548)2.07751745
84Chorioretinal coloboma (HP:0000567)2.03590738
85Gait imbalance (HP:0002141)2.01376516
86Congenital stationary night blindness (HP:0007642)17.0831639
87Drooling (HP:0002307)1.99981709
88Choroideremia (HP:0001139)1.99874300
89Renal hypoplasia (HP:0000089)1.98366790
90Calf muscle hypertrophy (HP:0008981)1.97977000
91Pachygyria (HP:0001302)1.96658443
92Disproportionate short-trunk short stature (HP:0003521)1.95937913
93Abnormal drinking behavior (HP:0030082)1.95307263
94Polydipsia (HP:0001959)1.95307263
95Visual hallucinations (HP:0002367)1.95298932
96Cerebellar dysplasia (HP:0007033)1.93965111
97Mutism (HP:0002300)1.93893989
98Abnormal hair whorl (HP:0010721)1.93380069
99Depression (HP:0000716)1.92020167
100Constricted visual fields (HP:0001133)1.91321289
101Dandy-Walker malformation (HP:0001305)1.90398763
102Intestinal atresia (HP:0011100)1.90171481
103Congenital primary aphakia (HP:0007707)1.90159880
104Generalized tonic-clonic seizures (HP:0002069)1.88747850
105Ventricular fibrillation (HP:0001663)1.87833285
106Impaired vibration sensation in the lower limbs (HP:0002166)1.87241740
107Inability to walk (HP:0002540)1.87096122
108Oligodactyly (hands) (HP:0001180)1.85642626
109Scanning speech (HP:0002168)1.85635980
110Growth hormone deficiency (HP:0000824)1.84734936
111Action tremor (HP:0002345)1.84295395
112Progressive inability to walk (HP:0002505)1.83258387
113Absent/shortened dynein arms (HP:0200106)1.82673146
114Dynein arm defect of respiratory motile cilia (HP:0012255)1.82673146
115Abnormal EKG (HP:0003115)1.82175693
116Poikiloderma (HP:0001029)1.81649159
117Astigmatism (HP:0000483)1.81507702
118Occipital encephalocele (HP:0002085)1.81366765
119Truncal ataxia (HP:0002078)1.79611168
120Unsteady gait (HP:0002317)1.78358440
121Primary adrenal insufficiency (HP:0008207)1.77835965
122Patellar aplasia (HP:0006443)1.76867365
123Bilateral microphthalmos (HP:0007633)1.76672143
124Excessive salivation (HP:0003781)1.76147074
125Aplasia/Hypoplasia of the uvula (HP:0010293)1.75547647
126Aqueductal stenosis (HP:0002410)1.74833231
127Broad foot (HP:0001769)1.74098056
128Urinary urgency (HP:0000012)1.73792454
129Congenital hepatic fibrosis (HP:0002612)1.73076385
130Abnormality of dental color (HP:0011073)1.73048748
131Nephrogenic diabetes insipidus (HP:0009806)1.73033662
132Preaxial hand polydactyly (HP:0001177)1.72466750
133Abnormality of glycine metabolism (HP:0010895)1.72412748
134Abnormality of serine family amino acid metabolism (HP:0010894)1.72412748
135Limb dystonia (HP:0002451)1.72244232
136Sloping forehead (HP:0000340)1.71956272
137Narrow forehead (HP:0000341)1.71641313
138Absent thumb (HP:0009777)1.70555012
139Abnormality of the pubic bones (HP:0003172)1.68817060
140Aplasia/Hypoplasia of the patella (HP:0006498)1.68710290
141Muscle hypertrophy of the lower extremities (HP:0008968)1.67993891
142Myokymia (HP:0002411)1.67757859
143Polyphagia (HP:0002591)1.67258553
144Postaxial foot polydactyly (HP:0001830)1.66776199
145Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66262487
146Abnormality of alanine metabolism (HP:0010916)1.66262487
147Hyperalaninemia (HP:0003348)1.66262487
148Aplasia/Hypoplasia of the tibia (HP:0005772)1.66097774
149Medial flaring of the eyebrow (HP:0010747)1.65795418
150Poor coordination (HP:0002370)1.63822811
151Genetic anticipation (HP:0003743)1.63369061
152Exercise-induced myalgia (HP:0003738)1.63201130
153Macular degeneration (HP:0000608)1.62181726
154Atrial fibrillation (HP:0005110)1.56296624
155Syncope (HP:0001279)1.55722317
156Exercise-induced muscle cramps (HP:0003710)1.51454157
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.49946514
158Gaze-evoked nystagmus (HP:0000640)1.48019842
159Neoplasm of the heart (HP:0100544)1.47250524
160Posterior subcapsular cataract (HP:0007787)1.46258026
161Long toe (HP:0010511)1.45920384
162Amelogenesis imperfecta (HP:0000705)1.45025236
163Supraventricular tachycardia (HP:0004755)1.44580703
164Myoglobinuria (HP:0002913)1.43709136
165Primary atrial arrhythmia (HP:0001692)1.43689346
166Optic disc pallor (HP:0000543)1.42985431
167Aplasia/Hypoplasia of the lens (HP:0008063)1.42568820
168Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.42270751
169Limb ataxia (HP:0002070)1.39811018
170Supraventricular arrhythmia (HP:0005115)1.38420308
171Maternal diabetes (HP:0009800)1.38123468
172Hypsarrhythmia (HP:0002521)1.37947056
173Atonic seizures (HP:0010819)1.36526695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.48175136
2TAOK24.04463258
3PAK63.54024780
4NEK13.50462763
5CASK3.35566220
6NME13.35200448
7RIPK12.93710496
8DYRK32.90149597
9TXK2.66795047
10PBK2.66769359
11PHKG12.64318220
12PHKG22.64318220
13DYRK1A2.50813585
14TRIM282.40483097
15BCR2.30941674
16STK382.28422345
17TNK22.28160966
18CLK12.23128998
19STK38L2.16482413
20INSRR2.15692936
21MARK12.10343379
22MINK12.05705464
23CDK32.04311953
24MAP4K21.93252576
25DYRK21.91658359
26BMPR1B1.88038979
27MAP3K41.85025733
28CDK191.84866220
29PLK41.79957801
30EPHA41.79055775
31ZAK1.78991202
32PINK11.77395518
33CAMK1D1.73981200
34ADRBK21.61475940
35MAP3K71.44941805
36GRK11.41007092
37CSNK1G21.40661557
38NTRK31.34057085
39CAMK2D1.33341666
40FES1.33119579
41OXSR11.31865311
42MKNK21.30908594
43RPS6KA41.28216486
44CAMK1G1.23577612
45FLT31.23300002
46ACVR1B1.20432734
47DYRK1B1.19897424
48IRAK11.19663628
49PRKAA11.18529468
50PLK21.17665342
51MAP3K131.16351904
52TNIK1.13129122
53SIK31.12669650
54SGK4941.11890339
55SGK2231.11890339
56MAP2K71.11489620
57PAK31.07553597
58EPHA31.06504355
59AKT31.05307255
60CSNK1G31.00262964
61CAMKK11.00052961
62CAMK10.99011997
63ERBB30.96679463
64BRD40.96637378
65TAF10.95555353
66PKN10.93296047
67NUAK10.91693236
68CDK140.91578816
69MAP2K40.90403299
70IRAK20.88834724
71CSNK1G10.86825819
72CSNK1A1L0.86371624
73TTK0.85341977
74FER0.81803271
75RPS6KA50.81076666
76PLK30.79917036
77PRKCG0.79916578
78PRKCZ0.76657976
79CAMKK20.74475230
80CDK150.73801628
81MKNK10.72569445
82PKN20.71130062
83PRKG20.69081767
84CDK180.68837335
85PRKCE0.68478446
86MARK20.65368721
87CAMK2A0.64168790
88CDK11A0.64098944
89MAPK100.63403259
90PLK10.63351776
91ROCK20.62985093
92CDK90.59880807
93EPHB20.59820861
94STK390.59373543
95SRPK10.58811633
96VRK10.58787630
97CDK80.58406477
98CDK50.57749578
99KSR20.57249106
100SIK20.56422547
101WNK40.55384767
102DAPK20.54388168
103CAMK40.51716736
104PRKAA20.50166775
105* PRKG10.49675918
106BCKDK0.49407018
107SGK20.49050637
108GSK3B0.48487060
109ADRBK10.48323445
110* PRKCA0.46760000
111BLK0.46586695
112PRKCB0.46263146
113PRKD20.46187963
114RPS6KA30.45624883
115STK110.44768933
116MAPK70.44192595
117MAPK90.42845803
118CHEK20.42440819
119TIE10.40002712
120UHMK10.39488737
121NTRK20.39408434
122WNK30.39140802
123MAP3K60.38885353
124CDC70.38307972
125* PRKACA0.38044842
126LIMK10.36516124
127PRKDC0.36165915
128ICK0.35442257
129MAPKAPK50.35401425
130BRAF0.34465293
131MAPK80.34444205
132FRK0.34374692
133AKT20.33663275
134KSR10.33283392
135BUB10.32751223
136MAPK140.29918329
137ARAF0.29296625
138GRK50.28443386
139PRKACG0.28294707
140MAP3K90.27510347
141ATM0.27474033
142CSNK1E0.27122856
143CSNK1D0.26837470
144PRKACB0.26725097
145MAPK130.26329710
146TAOK30.26222176
147CAMK2B0.26039423
148CDK120.25559529
149BRSK20.24181587
150CDK10.23760735
151YES10.22965936

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.17031621
2* GABAergic synapse_Homo sapiens_hsa047273.94974011
3* Nicotine addiction_Homo sapiens_hsa050333.70258901
4Phototransduction_Homo sapiens_hsa047443.65179596
5* Morphine addiction_Homo sapiens_hsa050323.20550086
6Circadian rhythm_Homo sapiens_hsa047103.14724146
7* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.98746586
8Circadian entrainment_Homo sapiens_hsa047132.73726986
9Olfactory transduction_Homo sapiens_hsa047402.53744311
10Oxidative phosphorylation_Homo sapiens_hsa001902.49776457
11Fructose and mannose metabolism_Homo sapiens_hsa000512.38694912
12Insulin secretion_Homo sapiens_hsa049112.22852402
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21970206
14Renin secretion_Homo sapiens_hsa049242.17272391
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.15768932
16Parkinsons disease_Homo sapiens_hsa050122.15332557
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.04642900
18Salivary secretion_Homo sapiens_hsa049702.01072557
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.00597011
20Basal transcription factors_Homo sapiens_hsa030221.97485720
21Cholinergic synapse_Homo sapiens_hsa047251.97276777
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94192974
23Glutamatergic synapse_Homo sapiens_hsa047241.89430362
24Propanoate metabolism_Homo sapiens_hsa006401.85176882
25Huntingtons disease_Homo sapiens_hsa050161.77979114
26Oxytocin signaling pathway_Homo sapiens_hsa049211.77944088
27Cardiac muscle contraction_Homo sapiens_hsa042601.77363171
28Linoleic acid metabolism_Homo sapiens_hsa005911.75399092
29Ether lipid metabolism_Homo sapiens_hsa005651.71818564
30Serotonergic synapse_Homo sapiens_hsa047261.71065125
31Proteasome_Homo sapiens_hsa030501.70078244
32Protein export_Homo sapiens_hsa030601.66791049
33Biosynthesis of amino acids_Homo sapiens_hsa012301.65249735
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.65215852
35Taste transduction_Homo sapiens_hsa047421.62445543
36Selenocompound metabolism_Homo sapiens_hsa004501.59413968
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54885118
38Alzheimers disease_Homo sapiens_hsa050101.52984744
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51446213
40Dilated cardiomyopathy_Homo sapiens_hsa054141.51354036
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.51236236
42Butanoate metabolism_Homo sapiens_hsa006501.46503844
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.42691434
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41952624
45Dopaminergic synapse_Homo sapiens_hsa047281.41386925
46Collecting duct acid secretion_Homo sapiens_hsa049661.40644258
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34201440
48Fat digestion and absorption_Homo sapiens_hsa049751.34149858
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.34083442
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33105649
51RNA polymerase_Homo sapiens_hsa030201.31679134
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30409172
53Mineral absorption_Homo sapiens_hsa049781.28950119
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27791404
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.27720319
56Regulation of autophagy_Homo sapiens_hsa041401.19570156
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17696628
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14112990
59Nitrogen metabolism_Homo sapiens_hsa009101.11949270
60Calcium signaling pathway_Homo sapiens_hsa040201.09995654
61Glycerolipid metabolism_Homo sapiens_hsa005611.08684054
62Pentose phosphate pathway_Homo sapiens_hsa000301.08587504
63Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03479174
64Fatty acid biosynthesis_Homo sapiens_hsa000611.01568206
65Galactose metabolism_Homo sapiens_hsa000520.98490008
66Steroid biosynthesis_Homo sapiens_hsa001000.98082165
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.97633704
68Gap junction_Homo sapiens_hsa045400.92257173
69RNA degradation_Homo sapiens_hsa030180.90232401
70RNA transport_Homo sapiens_hsa030130.89894342
71* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89648098
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.88249857
73Hedgehog signaling pathway_Homo sapiens_hsa043400.85159048
74Type II diabetes mellitus_Homo sapiens_hsa049300.84111104
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82513637
76Tryptophan metabolism_Homo sapiens_hsa003800.81927717
77Glutathione metabolism_Homo sapiens_hsa004800.81741162
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78367064
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.78053980
80Arachidonic acid metabolism_Homo sapiens_hsa005900.78009682
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.77760485
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75071591
83Long-term depression_Homo sapiens_hsa047300.74059355
84Chemical carcinogenesis_Homo sapiens_hsa052040.73518585
85Carbon metabolism_Homo sapiens_hsa012000.73176731
86cAMP signaling pathway_Homo sapiens_hsa040240.73009148
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71674095
88mRNA surveillance pathway_Homo sapiens_hsa030150.69595641
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68958412
90Metabolic pathways_Homo sapiens_hsa011000.67446040
91Non-homologous end-joining_Homo sapiens_hsa034500.67369841
92Inositol phosphate metabolism_Homo sapiens_hsa005620.66378107
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65010385
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64526162
95Homologous recombination_Homo sapiens_hsa034400.64246145
96Oocyte meiosis_Homo sapiens_hsa041140.62737652
97Vibrio cholerae infection_Homo sapiens_hsa051100.61597652
98Mismatch repair_Homo sapiens_hsa034300.60656516
99Peroxisome_Homo sapiens_hsa041460.60316960
100Pancreatic secretion_Homo sapiens_hsa049720.59662786
101Alcoholism_Homo sapiens_hsa050340.59604656
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59493138
103GnRH signaling pathway_Homo sapiens_hsa049120.57614083
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.57239825
105HIF-1 signaling pathway_Homo sapiens_hsa040660.57100739
106Basal cell carcinoma_Homo sapiens_hsa052170.55018880
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54433375
108N-Glycan biosynthesis_Homo sapiens_hsa005100.53045474
109p53 signaling pathway_Homo sapiens_hsa041150.52509902
110mTOR signaling pathway_Homo sapiens_hsa041500.51432698
111Tight junction_Homo sapiens_hsa045300.48399061
112ABC transporters_Homo sapiens_hsa020100.48010930
113Gastric acid secretion_Homo sapiens_hsa049710.47841072
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46751530
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46193637
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45258276
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44478802
118Spliceosome_Homo sapiens_hsa030400.43795163
119Bile secretion_Homo sapiens_hsa049760.43707256
120Caffeine metabolism_Homo sapiens_hsa002320.43625588
121Ovarian steroidogenesis_Homo sapiens_hsa049130.42268679
122Amphetamine addiction_Homo sapiens_hsa050310.41972807
123Renal cell carcinoma_Homo sapiens_hsa052110.41862387
124One carbon pool by folate_Homo sapiens_hsa006700.40964916
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40098510
126Glucagon signaling pathway_Homo sapiens_hsa049220.38304110
127Fatty acid metabolism_Homo sapiens_hsa012120.38041885
128MAPK signaling pathway_Homo sapiens_hsa040100.36566744
129Pyruvate metabolism_Homo sapiens_hsa006200.34589431
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.32045774
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31400032
132Purine metabolism_Homo sapiens_hsa002300.31272557
133Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30399725
134Arginine biosynthesis_Homo sapiens_hsa002200.30053359
135Long-term potentiation_Homo sapiens_hsa047200.28842066
136Thyroid hormone synthesis_Homo sapiens_hsa049180.28695453
137Sphingolipid metabolism_Homo sapiens_hsa006000.27918301
138Cocaine addiction_Homo sapiens_hsa050300.24796551
139Lysine degradation_Homo sapiens_hsa003100.22693038
140Protein digestion and absorption_Homo sapiens_hsa049740.22179228
141Choline metabolism in cancer_Homo sapiens_hsa052310.21067278
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20545929
143Rheumatoid arthritis_Homo sapiens_hsa053230.20409783
144Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20358212
145ErbB signaling pathway_Homo sapiens_hsa040120.19362221
146Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19121067
147Melanoma_Homo sapiens_hsa052180.19118927
148Ras signaling pathway_Homo sapiens_hsa040140.15519862
149Axon guidance_Homo sapiens_hsa043600.14895380
150Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.14852098
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.14757363
152Fanconi anemia pathway_Homo sapiens_hsa034600.11560651
153AMPK signaling pathway_Homo sapiens_hsa041520.11472882
154Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11274778
155Retinol metabolism_Homo sapiens_hsa008300.10922512
156Endometrial cancer_Homo sapiens_hsa052130.09522030
157Phenylalanine metabolism_Homo sapiens_hsa003600.08428009
158alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.07948127
159SNARE interactions in vesicular transport_Homo sapiens_hsa041300.06662467

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