GAD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.50974868
2vocalization behavior (GO:0071625)6.21816919
3gamma-aminobutyric acid transport (GO:0015812)6.08751659
4regulation of short-term neuronal synaptic plasticity (GO:0048172)6.03987958
5synaptic vesicle exocytosis (GO:0016079)5.73916712
6negative regulation of synaptic transmission, GABAergic (GO:0032229)5.49661592
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.42854638
8nucleobase catabolic process (GO:0046113)5.30048316
9* neurotransmitter secretion (GO:0007269)5.20428401
10locomotory exploration behavior (GO:0035641)5.17247755
11regulation of glutamate receptor signaling pathway (GO:1900449)5.14041269
12neuronal action potential propagation (GO:0019227)5.11498552
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.10821903
14synaptic vesicle maturation (GO:0016188)5.06431664
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.06218674
16positive regulation of mitochondrial fission (GO:0090141)4.93634417
17regulation of synaptic vesicle exocytosis (GO:2000300)4.90972641
18neuron cell-cell adhesion (GO:0007158)4.88102858
19glutamate secretion (GO:0014047)4.69201560
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.64949032
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.62688191
22neurotransmitter-gated ion channel clustering (GO:0072578)4.62003099
23glycosphingolipid biosynthetic process (GO:0006688)4.54693558
24neuron-neuron synaptic transmission (GO:0007270)4.53546037
25establishment of mitochondrion localization (GO:0051654)4.49793374
26protein localization to synapse (GO:0035418)4.38764070
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.33527642
28regulation of synaptic vesicle transport (GO:1902803)4.32807032
29gamma-aminobutyric acid signaling pathway (GO:0007214)4.32089773
30synaptic transmission, glutamatergic (GO:0035249)4.27013882
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.13566765
32regulation of synapse structural plasticity (GO:0051823)4.13555142
33positive regulation of synapse maturation (GO:0090129)4.05779826
34exploration behavior (GO:0035640)4.04496973
35regulation of neuronal synaptic plasticity (GO:0048168)4.04191990
36glutamate receptor signaling pathway (GO:0007215)4.01237830
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.99317092
38* neurotransmitter transport (GO:0006836)3.98874081
39synaptic vesicle docking involved in exocytosis (GO:0016081)3.97085661
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.94209895
41long-term memory (GO:0007616)3.92304622
42regulation of synaptic transmission, GABAergic (GO:0032228)3.91069576
43startle response (GO:0001964)3.82792048
44striatum development (GO:0021756)3.78443975
45* regulation of neurotransmitter levels (GO:0001505)3.75246283
46negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.75033152
47protein insertion into membrane (GO:0051205)3.74490567
48positive regulation of membrane potential (GO:0045838)3.74081747
49positive regulation of synaptic transmission, GABAergic (GO:0032230)3.71153751
50regulation of synaptic transmission, glutamatergic (GO:0051966)3.69111077
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.66320764
52long-term synaptic potentiation (GO:0060291)3.65054863
53amino acid import (GO:0043090)3.62456327
54layer formation in cerebral cortex (GO:0021819)3.59377505
55proline transport (GO:0015824)3.56883270
56axonal fasciculation (GO:0007413)3.55940006
57cerebellar Purkinje cell differentiation (GO:0021702)3.55089042
58ATP hydrolysis coupled proton transport (GO:0015991)3.54475925
59energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.54475925
60detection of calcium ion (GO:0005513)3.53894403
61transmission of nerve impulse (GO:0019226)3.47408296
62cell migration in hindbrain (GO:0021535)3.46653922
63neuromuscular process controlling posture (GO:0050884)3.44957550
64regulation of vesicle fusion (GO:0031338)3.44140733
65substrate-independent telencephalic tangential migration (GO:0021826)3.41314956
66substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.41314956
67regulation of mitochondrial fission (GO:0090140)3.40737725
68response to histamine (GO:0034776)3.40324391
69C4-dicarboxylate transport (GO:0015740)3.39159007
70regulation of postsynaptic membrane potential (GO:0060078)3.38864697
71negative regulation of oligodendrocyte differentiation (GO:0048715)3.38099404
72presynaptic membrane assembly (GO:0097105)3.37849273
73regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.37170214
74positive regulation of amino acid transport (GO:0051957)3.36379084
75regulation of synapse maturation (GO:0090128)3.35385360
76regulation of synaptic plasticity (GO:0048167)3.35349952
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.35221188
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.34030528
79behavioral response to cocaine (GO:0048148)3.33350893
80regulation of penile erection (GO:0060405)3.33143710
81transferrin transport (GO:0033572)3.32283947
82cAMP catabolic process (GO:0006198)3.31219143
83activation of protein kinase A activity (GO:0034199)3.30958097
84synaptic transmission, dopaminergic (GO:0001963)3.30249558
85calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.29741952
86glycine transport (GO:0015816)3.29307403
87neuron recognition (GO:0008038)3.28603716
88L-serine transport (GO:0015825)3.28180532
89response to dietary excess (GO:0002021)3.27823651
90regulation of neurotransmitter secretion (GO:0046928)3.27085238
91learning (GO:0007612)3.24194760
92regulation of female receptivity (GO:0045924)3.23075036
93synapse assembly (GO:0007416)3.22945450
94presynaptic membrane organization (GO:0097090)3.22200829
95* synaptic transmission (GO:0007268)3.21528991
96postsynaptic membrane organization (GO:0001941)3.21484064
97positive regulation of synapse assembly (GO:0051965)3.20965005
98membrane hyperpolarization (GO:0060081)3.20311501
99hippocampus development (GO:0021766)3.20293748
100dendrite morphogenesis (GO:0048813)3.20212863
101behavioral response to ethanol (GO:0048149)3.17486874
102prepulse inhibition (GO:0060134)3.16994919
103regulation of neurotransmitter transport (GO:0051588)3.16756242
104positive regulation of action potential (GO:0045760)3.16716550
105dendritic spine morphogenesis (GO:0060997)3.14326877
106cerebellar granule cell differentiation (GO:0021707)3.14253135
107response to auditory stimulus (GO:0010996)3.14202054
108response to cocaine (GO:0042220)3.13641338
109ferric iron transport (GO:0015682)3.11258270
110trivalent inorganic cation transport (GO:0072512)3.11258270
111positive regulation of synaptic transmission (GO:0050806)3.11076434
112female mating behavior (GO:0060180)3.10982252
113G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09617860
114neuronal ion channel clustering (GO:0045161)3.08005748
115mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.07802244
116regulation of dendritic spine morphogenesis (GO:0061001)3.07751153
117membrane depolarization (GO:0051899)3.06227133
118synaptic vesicle endocytosis (GO:0048488)3.05559431
119regulation of feeding behavior (GO:0060259)3.05443164
120negative regulation of dendrite morphogenesis (GO:0050774)3.04883454
121regulation of synaptic transmission (GO:0050804)3.03586741
122cyclic nucleotide catabolic process (GO:0009214)3.02593971
123establishment of synaptic vesicle localization (GO:0097480)3.02592730
124synaptic vesicle transport (GO:0048489)3.02592730
125cellular potassium ion homeostasis (GO:0030007)3.02539523
126auditory behavior (GO:0031223)3.01003448
127intraspecies interaction between organisms (GO:0051703)2.99988957
128social behavior (GO:0035176)2.99988957
129establishment of vesicle localization (GO:0051650)2.98050275
130protein localization to cilium (GO:0061512)2.96230091
131establishment of melanosome localization (GO:0032401)2.90621378
132protein polyglutamylation (GO:0018095)2.90404502
133acidic amino acid transport (GO:0015800)2.88888294
134synapse organization (GO:0050808)2.87646833
135melanosome transport (GO:0032402)2.84929120
136nonmotile primary cilium assembly (GO:0035058)2.82992532
137regulation of smooth muscle cell apoptotic process (GO:0034391)2.81692942
138eosinophil chemotaxis (GO:0048245)2.77578572
139sialylation (GO:0097503)2.76850604
140positive regulation of potassium ion transmembrane transport (GO:1901381)2.76194403
141establishment of pigment granule localization (GO:0051905)2.75446612
142regulation of protein kinase A signaling (GO:0010738)2.72915073
143DNA double-strand break processing (GO:0000729)2.72120745
144pigment granule transport (GO:0051904)2.69323331
145regulation of synapse assembly (GO:0051963)2.68914194
146positive regulation of dendritic spine morphogenesis (GO:0061003)2.68209938
147glial cell proliferation (GO:0014009)2.66885444
148sulfation (GO:0051923)2.66664257

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.24509060
2GBX2_23144817_ChIP-Seq_PC3_Human4.06734559
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.24628320
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.17437435
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97096292
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.86888697
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.77179260
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66616274
9* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57403886
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56249199
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56249199
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54471947
13* RARB_27405468_Chip-Seq_BRAIN_Mouse2.50157784
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49924606
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46666575
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46547052
17TAF15_26573619_Chip-Seq_HEK293_Human2.41647909
18* EZH2_27304074_Chip-Seq_ESCs_Mouse2.39073996
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34905050
20* REST_18959480_ChIP-ChIP_MESCs_Mouse2.33943961
21DROSHA_22980978_ChIP-Seq_HELA_Human2.26984293
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25562225
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.25153403
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15751309
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13024446
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.12176790
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.08981325
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03117886
29* RNF2_27304074_Chip-Seq_ESCs_Mouse2.03103989
30IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00761501
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97254917
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91399076
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88429291
34SMAD4_21799915_ChIP-Seq_A2780_Human1.87893385
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86959121
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85064921
37AR_21572438_ChIP-Seq_LNCaP_Human1.82170781
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82010653
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71574551
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71540477
41P300_19829295_ChIP-Seq_ESCs_Human1.62791667
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61333331
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.60077806
44* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.54845967
45EWS_26573619_Chip-Seq_HEK293_Human1.46747043
46* SOX2_21211035_ChIP-Seq_LN229_Gbm1.46091606
47* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43194211
48AR_25329375_ChIP-Seq_VCAP_Human1.40893100
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40354597
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40177709
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39966414
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.39521667
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.37399107
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37083849
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35498486
56ZNF274_21170338_ChIP-Seq_K562_Hela1.35288057
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34116405
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33235065
59IGF1R_20145208_ChIP-Seq_DFB_Human1.32461125
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31804030
61* CBX2_27304074_Chip-Seq_ESCs_Mouse1.30597552
62IRF1_19129219_ChIP-ChIP_H3396_Human1.30551895
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29654911
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.28827865
65FUS_26573619_Chip-Seq_HEK293_Human1.28544882
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26697791
67RNF2_27304074_Chip-Seq_NSC_Mouse1.25700673
68* STAT3_23295773_ChIP-Seq_U87_Human1.25416234
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22215923
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21584083
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20912313
72* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19625478
73AR_19668381_ChIP-Seq_PC3_Human1.19364149
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18078181
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.17845773
76* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17270418
77GABP_17652178_ChIP-ChIP_JURKAT_Human1.15294996
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14978658
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14303125
80ER_23166858_ChIP-Seq_MCF-7_Human1.14033543
81* TCF4_23295773_ChIP-Seq_U87_Human1.12951879
82* RING1B_27294783_Chip-Seq_ESCs_Mouse1.12810292
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11446862
84RUNX2_22187159_ChIP-Seq_PCA_Human1.11080008
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10832559
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09926406
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09171719
88EST1_17652178_ChIP-ChIP_JURKAT_Human1.08772792
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.08377467
90P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08110224
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07339058
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05966440
93KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.05633088
94JUN_21703547_ChIP-Seq_K562_Human1.05439229
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03513748
96AHR_22903824_ChIP-Seq_MCF-7_Human1.02818059
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02498378
98ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98081074
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.97453477
100TP53_22573176_ChIP-Seq_HFKS_Human0.97305354
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96829127
102POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96471426
103PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95977084
104SMAD3_21741376_ChIP-Seq_ESCs_Human0.95098842
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92729932
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91008874
107BCAT_22108803_ChIP-Seq_LS180_Human0.90908946
108ETS1_20019798_ChIP-Seq_JURKAT_Human0.90772046
109WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90214476
110NANOG_18555785_Chip-Seq_ESCs_Mouse0.90054650
111THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90043488
112VDR_22108803_ChIP-Seq_LS180_Human0.89512100
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89178725
114KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88925011
115RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88499602
116CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88404695
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88343713
118SOX9_26525672_Chip-Seq_HEART_Mouse0.88198926
119FLI1_21867929_ChIP-Seq_TH2_Mouse0.88023841
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87754110
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87538765
122CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87281920
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86419425
124CBP_20019798_ChIP-Seq_JUKART_Human0.86419425
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.86301118
126* RING1B_27294783_Chip-Seq_NPCs_Mouse0.85334840
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84957113
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.84571486

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.73503424
2MP0002822_catalepsy4.62687782
3* MP0003635_abnormal_synaptic_transmissio4.12310032
4MP0009046_muscle_twitch4.11204257
5MP0009745_abnormal_behavioral_response3.80604394
6MP0002064_seizures3.61485024
7MP0003880_abnormal_central_pattern3.55110778
8MP0002063_abnormal_learning/memory/cond3.29878142
9MP0002572_abnormal_emotion/affect_behav2.97861872
10MP0004270_analgesia2.80336886
11* MP0002272_abnormal_nervous_system2.77230685
12MP0001968_abnormal_touch/_nociception2.62201800
13MP0001486_abnormal_startle_reflex2.58113925
14MP0001501_abnormal_sleep_pattern2.57238335
15MP0002734_abnormal_mechanical_nocicepti2.52641574
16MP0002735_abnormal_chemical_nociception2.34730107
17MP0005423_abnormal_somatic_nervous2.27803655
18MP0002102_abnormal_ear_morphology2.24900134
19MP0002736_abnormal_nociception_after2.13200787
20MP0005646_abnormal_pituitary_gland2.12571835
21MP0009780_abnormal_chondrocyte_physiolo2.10991278
22MP0008569_lethality_at_weaning2.08390058
23MP0003787_abnormal_imprinting2.02175582
24MP0008789_abnormal_olfactory_epithelium1.99398629
25MP0002067_abnormal_sensory_capabilities1.97383140
26MP0001970_abnormal_pain_threshold1.92963097
27MP0002733_abnormal_thermal_nociception1.92810388
28MP0001440_abnormal_grooming_behavior1.89777279
29MP0001984_abnormal_olfaction1.86857943
30MP0002557_abnormal_social/conspecific_i1.84594498
31MP0000049_abnormal_middle_ear1.83263833
32MP0000013_abnormal_adipose_tissue1.81056434
33MP0002184_abnormal_innervation1.79733101
34MP0001529_abnormal_vocalization1.77695101
35MP0002909_abnormal_adrenal_gland1.74695578
36MP0002837_dystrophic_cardiac_calcinosis1.72951507
37MP0004924_abnormal_behavior1.72899366
38MP0005386_behavior/neurological_phenoty1.72899366
39MP0001188_hyperpigmentation1.69776356
40MP0003122_maternal_imprinting1.62366210
41MP0003879_abnormal_hair_cell1.58010805
42* MP0004811_abnormal_neuron_physiology1.53351002
43MP0004142_abnormal_muscle_tone1.48295712
44MP0001986_abnormal_taste_sensitivity1.47542394
45MP0003329_amyloid_beta_deposits1.46844674
46MP0005645_abnormal_hypothalamus_physiol1.46406053
47MP0006276_abnormal_autonomic_nervous1.46325503
48MP0004858_abnormal_nervous_system1.40912362
49* MP0002066_abnormal_motor_capabilities/c1.39624423
50MP0002751_abnormal_autonomic_nervous1.39551602
51MP0000955_abnormal_spinal_cord1.39084557
52MP0004885_abnormal_endolymph1.35169075
53MP0002653_abnormal_ependyma_morphology1.31839350
54MP0000778_abnormal_nervous_system1.31700828
55MP0003938_abnormal_ear_development1.28315398
56MP0003221_abnormal_cardiomyocyte_apopto1.26659950
57* MP0002882_abnormal_neuron_morphology1.25545166
58MP0003646_muscle_fatigue1.18316966
59MP0002876_abnormal_thyroid_physiology1.17884609
60MP0003633_abnormal_nervous_system1.08201600
61MP0010386_abnormal_urinary_bladder1.06987183
62* MP0001270_distended_abdomen1.06648669
63MP0001502_abnormal_circadian_rhythm1.03981952
64MP0008058_abnormal_DNA_repair1.03806999
65MP0008872_abnormal_physiological_respon1.03703102
66MP0005253_abnormal_eye_physiology1.03121752
67MP0001905_abnormal_dopamine_level1.02960874
68MP0004043_abnormal_pH_regulation1.02648876
69* MP0002152_abnormal_brain_morphology0.96328036
70MP0004233_abnormal_muscle_weight0.94925571
71* MP0002069_abnormal_eating/drinking_beha0.94029035
72MP0002638_abnormal_pupillary_reflex0.93890004
73MP0004085_abnormal_heartbeat0.93572516
74MP0005551_abnormal_eye_electrophysiolog0.91607649
75MP0002229_neurodegeneration0.90999512
76MP0005187_abnormal_penis_morphology0.90630762
77MP0005394_taste/olfaction_phenotype0.90190905
78MP0005499_abnormal_olfactory_system0.90190905
79MP0008874_decreased_physiological_sensi0.90140636
80MP0004215_abnormal_myocardial_fiber0.89215841
81MP0005367_renal/urinary_system_phenotyp0.87955806
82MP0000516_abnormal_urinary_system0.87955806
83* MP0003631_nervous_system_phenotype0.85924193
84MP0004484_altered_response_of0.85733850
85MP0000751_myopathy0.85559450
86MP0003119_abnormal_digestive_system0.85529180
87MP0006035_abnormal_mitochondrial_morpho0.84604909
88MP0002234_abnormal_pharynx_morphology0.83669022
89MP0000026_abnormal_inner_ear0.81645084
90MP0001963_abnormal_hearing_physiology0.81496688
91MP0002233_abnormal_nose_morphology0.76590008
92MP0002090_abnormal_vision0.76335493
93MP0002277_abnormal_respiratory_mucosa0.75777508
94MP0006072_abnormal_retinal_apoptosis0.75528875
95MP0005535_abnormal_body_temperature0.74801035
96MP0005623_abnormal_meninges_morphology0.72179810
97MP0008877_abnormal_DNA_methylation0.70907508
98MP0003121_genomic_imprinting0.70473796
99* MP0003861_abnormal_nervous_system0.70078998
100MP0004742_abnormal_vestibular_system0.69680088
101MP0003634_abnormal_glial_cell0.68307251
102MP0002249_abnormal_larynx_morphology0.67876205
103MP0001299_abnormal_eye_distance/0.66950561
104MP0002752_abnormal_somatic_nervous0.65249967
105MP0000631_abnormal_neuroendocrine_gland0.64929989
106MP0000750_abnormal_muscle_regeneration0.64187419
107* MP0003755_abnormal_palate_morphology0.64082836
108MP0003137_abnormal_impulse_conducting0.63476826
109MP0003690_abnormal_glial_cell0.63335102
110MP0001664_abnormal_digestion0.62274244
111MP0000604_amyloidosis0.60075593
112* MP0001177_atelectasis0.59623690
113MP0003283_abnormal_digestive_organ0.59262665
114MP0003183_abnormal_peptide_metabolism0.58846610
115MP0004147_increased_porphyrin_level0.57219655
116MP0010770_preweaning_lethality0.55180821
117MP0002082_postnatal_lethality0.55180821
118MP0005171_absent_coat_pigmentation0.54875021
119MP0000569_abnormal_digit_pigmentation0.53966846
120* MP0001943_abnormal_respiration0.53681830
121* MP0003632_abnormal_nervous_system0.53643739
122MP0010769_abnormal_survival0.53177214
123MP0005167_abnormal_blood-brain_barrier0.52722107
124MP0003123_paternal_imprinting0.52694017
125MP0002332_abnormal_exercise_endurance0.50042160
126MP0010768_mortality/aging0.49649853

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.39226625
2Atonic seizures (HP:0010819)6.54823910
3Febrile seizures (HP:0002373)6.09711399
4Focal seizures (HP:0007359)5.95590635
5Myokymia (HP:0002411)5.61932235
6Epileptic encephalopathy (HP:0200134)5.39448799
7Absence seizures (HP:0002121)4.96831039
8Visual hallucinations (HP:0002367)4.75517633
9Hyperventilation (HP:0002883)4.60076927
10Dialeptic seizures (HP:0011146)4.45279055
11Progressive cerebellar ataxia (HP:0002073)4.15077888
12Generalized tonic-clonic seizures (HP:0002069)4.12580117
13Split foot (HP:0001839)4.09100574
14Progressive inability to walk (HP:0002505)4.08855151
15Gaze-evoked nystagmus (HP:0000640)3.67329498
16Retinal dysplasia (HP:0007973)3.66424744
17Lissencephaly (HP:0001339)3.62722805
18Broad-based gait (HP:0002136)3.48929247
19Amyotrophic lateral sclerosis (HP:0007354)3.47424645
20Impaired social interactions (HP:0000735)3.41547507
21Abnormal social behavior (HP:0012433)3.41547507
22Dysdiadochokinesis (HP:0002075)3.31892726
23Poor eye contact (HP:0000817)3.28327664
24Abnormal eating behavior (HP:0100738)3.23916618
25Cortical dysplasia (HP:0002539)3.16863205
26Truncal ataxia (HP:0002078)3.15811035
27Resting tremor (HP:0002322)2.94540771
28Vaginal atresia (HP:0000148)2.93573792
29Action tremor (HP:0002345)2.93388478
30Anxiety (HP:0000739)2.92983229
31Impaired vibration sensation in the lower limbs (HP:0002166)2.90700762
32Polyphagia (HP:0002591)2.90276112
33Genital tract atresia (HP:0001827)2.90207662
34Depression (HP:0000716)2.88437259
35Diplopia (HP:0000651)2.86039440
36Abnormality of binocular vision (HP:0011514)2.86039440
37Pachygyria (HP:0001302)2.81784808
38Pheochromocytoma (HP:0002666)2.79714636
39Epileptiform EEG discharges (HP:0011182)2.77933880
40Inability to walk (HP:0002540)2.75232342
41Scanning speech (HP:0002168)2.74453631
42Status epilepticus (HP:0002133)2.74200649
43EEG with generalized epileptiform discharges (HP:0011198)2.69825407
44Hypsarrhythmia (HP:0002521)2.66432916
45Peripheral hypomyelination (HP:0007182)2.65781740
46Ankle clonus (HP:0011448)2.63811393
47Absent speech (HP:0001344)2.63607239
48Abnormal hair whorl (HP:0010721)2.58590658
49Dysmetria (HP:0001310)2.58343779
50Neuroendocrine neoplasm (HP:0100634)2.54733259
51Drooling (HP:0002307)2.54074221
52Excessive salivation (HP:0003781)2.54074221
53* Spastic tetraplegia (HP:0002510)2.53674617
54Hepatoblastoma (HP:0002884)2.53003933
55Abnormality of the corticospinal tract (HP:0002492)2.52194613
56Postural instability (HP:0002172)2.51011785
57Dysmetric saccades (HP:0000641)2.50792420
58Failure to thrive in infancy (HP:0001531)2.50326369
59Hemiplegia (HP:0002301)2.46448158
60Cerebral hypomyelination (HP:0006808)2.45712433
61Limb dystonia (HP:0002451)2.41629096
62Poor coordination (HP:0002370)2.40633786
63Hypoplasia of the brainstem (HP:0002365)2.40434538
64Aplasia/Hypoplasia of the brainstem (HP:0007362)2.40434538
65Urinary bladder sphincter dysfunction (HP:0002839)2.39392322
66Generalized myoclonic seizures (HP:0002123)2.37780110
67Impaired smooth pursuit (HP:0007772)2.37190133
68Mutism (HP:0002300)2.37066409
69Delusions (HP:0000746)2.37065044
70Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.36205158
71Degeneration of the lateral corticospinal tracts (HP:0002314)2.36205158
72Fetal akinesia sequence (HP:0001989)2.35837239
73Hemiparesis (HP:0001269)2.34938370
74Poor suck (HP:0002033)2.34786482
75Thyroid-stimulating hormone excess (HP:0002925)2.32825906
76Supranuclear gaze palsy (HP:0000605)2.32391762
77Genetic anticipation (HP:0003743)2.30924802
78Atrophy/Degeneration involving motor neurons (HP:0007373)2.28922438
79Lower limb muscle weakness (HP:0007340)2.28498503
80Gait imbalance (HP:0002141)2.27866884
81Amblyopia (HP:0000646)2.27052515
82Focal dystonia (HP:0004373)2.25425634
83Bradykinesia (HP:0002067)2.25181060
84Pendular nystagmus (HP:0012043)2.24321682
85Type II lissencephaly (HP:0007260)2.23016499
86Annular pancreas (HP:0001734)2.22885800
87Abnormal mitochondria in muscle tissue (HP:0008316)2.22470814
88Broad alveolar ridges (HP:0000187)2.21413135
89Torticollis (HP:0000473)2.20363271
90Clonus (HP:0002169)2.20094927
91Hypoplasia of the corpus callosum (HP:0002079)2.19482613
92Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.17408557
93Blue irides (HP:0000635)2.17252752
94Acute necrotizing encephalopathy (HP:0006965)2.16899362
95Protruding tongue (HP:0010808)2.16686480
96Upper limb muscle weakness (HP:0003484)2.16258434
97Intention tremor (HP:0002080)2.15509850
98Abnormality of ocular smooth pursuit (HP:0000617)2.11504346
99Abnormality of the lower motor neuron (HP:0002366)2.10580156
100Intellectual disability, severe (HP:0010864)2.09841226
101Gait ataxia (HP:0002066)2.09837779
102Neoplasm of the peripheral nervous system (HP:0100007)2.09727279
103Specific learning disability (HP:0001328)2.08879746
104Progressive macrocephaly (HP:0004481)2.08546763
105Spastic gait (HP:0002064)2.08185624
106Hyperthyroidism (HP:0000836)2.08142563
107Oligomenorrhea (HP:0000876)2.05814765
108Broad foot (HP:0001769)2.03551769
109Decreased testicular size (HP:0008734)2.02886234
110CNS hypomyelination (HP:0003429)2.02536682
111Muscular hypotonia of the trunk (HP:0008936)2.01475379
112Neuronal loss in central nervous system (HP:0002529)2.00645998
113Impaired vibratory sensation (HP:0002495)2.00555459
114Urinary urgency (HP:0000012)2.00306359
115Congenital primary aphakia (HP:0007707)1.98735405
116Dyskinesia (HP:0100660)1.97782244
117Aplasia/Hypoplasia of the lens (HP:0008063)1.95605517
118Paraplegia (HP:0010550)1.95392387
119Stereotypic behavior (HP:0000733)1.94248651
120Generalized hypotonia (HP:0001290)1.93687300
121Medial flaring of the eyebrow (HP:0010747)1.92759188
122Abnormality of the musculature of the pelvis (HP:0001469)1.89529778
123Abnormality of the hip-girdle musculature (HP:0001445)1.89529778
124Craniofacial dystonia (HP:0012179)1.87948280
125Papilledema (HP:0001085)1.87700520
126Abnormality of the labia minora (HP:0012880)1.85100026
127Nephrogenic diabetes insipidus (HP:0009806)1.84762434
128Psychosis (HP:0000709)1.83915632
129Agitation (HP:0000713)1.82760977
130Narrow nasal bridge (HP:0000446)1.79842756
131Abnormality of salivation (HP:0100755)1.79215464
132Esotropia (HP:0000565)1.79157303
133Astrocytoma (HP:0009592)1.78360703
134Abnormality of the astrocytes (HP:0100707)1.78360703
135Thickened helices (HP:0000391)1.78046948
136Horizontal nystagmus (HP:0000666)1.77920588
137Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.77843254
138Intellectual disability, progressive (HP:0006887)1.77729911
139Aplasia/Hypoplasia of the sternum (HP:0006714)1.75911403
140Sleep apnea (HP:0010535)1.75750276
141Morphological abnormality of the pyramidal tract (HP:0002062)1.74297540
142Abnormality of saccadic eye movements (HP:0000570)1.73500790
143Intellectual disability, moderate (HP:0002342)1.73406751
144Progressive microcephaly (HP:0000253)1.72591809
145Lower limb asymmetry (HP:0100559)1.72160760
146Cortical visual impairment (HP:0100704)1.71244159
147Postural tremor (HP:0002174)1.70511199
148Tented upper lip vermilion (HP:0010804)1.70124240
149Spinal canal stenosis (HP:0003416)1.70040466
150Spastic paraplegia (HP:0001258)1.69771650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.37381374
2BCR3.89558936
3MAP3K43.70373422
4MAP2K73.49530575
5EPHA43.41667677
6MAP3K93.13798357
7CASK3.10192171
8MAP3K122.94391739
9MARK12.57473235
10TRIM282.52577765
11MINK12.40135550
12NTRK22.37269158
13STK38L2.29332162
14MAP2K42.26662205
15CSNK1A1L2.14693118
16CSNK1G32.12785946
17MAP4K21.99177204
18EPHA31.80410987
19DAPK21.71355934
20ERBB41.70908323
21CSNK1G11.69216939
22DYRK21.65211256
23AKT31.63684827
24PLK21.55441453
25DAPK11.54515329
26CAMKK11.53648977
27TNIK1.50390965
28PAK61.49692597
29RPS6KA41.49083318
30CDK51.47450120
31PRKCG1.45534672
32PNCK1.44935839
33PDK31.42724774
34PDK41.42724774
35NTRK11.42128010
36GRK51.40870073
37FES1.40718650
38CAMKK21.36517279
39TSSK61.35604513
40ERBB31.33238132
41PRPF4B1.32985975
42KSR21.32383569
43PRKD31.24058379
44SIK21.21785095
45SGK21.20372019
46ARAF1.19359393
47SGK2231.17062278
48SGK4941.17062278
49KSR11.16741770
50FRK1.16551803
51RIPK41.15672129
52LIMK11.15125933
53STK381.03477465
54CAMK2A1.03137500
55UHMK11.02869085
56MAPK130.99504173
57CDK190.96822867
58MUSK0.95547668
59CAMK10.94848582
60PRKCH0.92415987
61SGK30.91971349
62TESK10.86548543
63PINK10.84248101
64CAMK2B0.83225595
65PDK20.82866420
66SRPK10.81076931
67MAP3K20.80755716
68NME10.80409201
69CDK180.76959744
70TESK20.76344717
71BMPR1B0.75890542
72MAP3K130.75416249
73CDK140.74890982
74TYRO30.73885802
75CDK150.73224504
76TNK20.72822666
77SGK10.70528728
78SCYL20.69004441
79NEK10.67711114
80DYRK1A0.66996543
81CCNB10.66206509
82STK110.65611920
83PHKG10.64589743
84PHKG20.64589743
85ALK0.64283486
86BRAF0.63347866
87* PRKCE0.63069632
88OXSR10.62943006
89CDK11A0.61232726
90CAMK2G0.61220017
91MAP3K60.59907415
92BMPR20.59400874
93WNK30.59042568
94TAOK10.58550485
95SIK30.58401063
96CSNK1G20.57839545
97WNK10.56337464
98CSNK1D0.53238952
99CAMK2D0.53093614
100RPS6KA30.52406560
101CAMK40.51940267
102CDK80.49435231
103MAP3K10.48992803
104FER0.48708574
105MARK20.46980888
106RPS6KA50.46643757
107NEK60.46604252
108PAK30.46441334
109PRKCZ0.46285536
110PDK10.46054203
111CSNK1A10.45915700
112FYN0.44875835
113INSRR0.44783244
114MAP2K10.44188184
115RAF10.43123062
116RET0.41764787
117PRKCB0.41679601
118MAP3K50.41627833
119PKN10.41317716
120GRK70.40602626
121LATS20.40535242
122DYRK1B0.39449510
123PDPK10.39255232
124* PRKACA0.38327069
125BRD40.38139383
126PRKAA10.38075677
127TAOK30.34476470
128ADRBK20.34090928
129PRKACB0.29567533
130MAPK90.27987722
131LMTK20.27839900
132CDK30.27182094
133CSNK1E0.25798473
134PIM20.25454400
135PRKCA0.21624231
136PRKACG0.20265438
137PRKDC0.20236905
138FGFR20.19831460
139EGFR0.19773796

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.22900441
2Synaptic vesicle cycle_Homo sapiens_hsa047213.98233278
3* GABAergic synapse_Homo sapiens_hsa047273.24995394
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.96815370
5Collecting duct acid secretion_Homo sapiens_hsa049662.87503541
6Morphine addiction_Homo sapiens_hsa050322.79026566
7Olfactory transduction_Homo sapiens_hsa047402.56443361
8Circadian entrainment_Homo sapiens_hsa047132.51416498
9Glutamatergic synapse_Homo sapiens_hsa047242.34386164
10Long-term potentiation_Homo sapiens_hsa047202.33888514
11Amphetamine addiction_Homo sapiens_hsa050312.10977618
12Dopaminergic synapse_Homo sapiens_hsa047282.06690801
13Taste transduction_Homo sapiens_hsa047422.00561869
14* Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95394837
15Salivary secretion_Homo sapiens_hsa049701.89075206
16Long-term depression_Homo sapiens_hsa047301.88785316
17Insulin secretion_Homo sapiens_hsa049111.81057169
18Vibrio cholerae infection_Homo sapiens_hsa051101.79203839
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78858446
20Cholinergic synapse_Homo sapiens_hsa047251.74599581
21Serotonergic synapse_Homo sapiens_hsa047261.71381453
22Cocaine addiction_Homo sapiens_hsa050301.52819031
23Gastric acid secretion_Homo sapiens_hsa049711.52003455
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50386981
25Calcium signaling pathway_Homo sapiens_hsa040201.49233850
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46416205
27Renin secretion_Homo sapiens_hsa049241.42194889
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41784823
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41689839
30Oxidative phosphorylation_Homo sapiens_hsa001901.36715070
31Oxytocin signaling pathway_Homo sapiens_hsa049211.34696826
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28358416
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26196671
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25141768
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24379439
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21370875
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17509706
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17373281
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15836067
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14666653
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14364547
42Gap junction_Homo sapiens_hsa045401.13496043
43Cardiac muscle contraction_Homo sapiens_hsa042601.12877926
44Protein export_Homo sapiens_hsa030601.09220152
45* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08396489
46cAMP signaling pathway_Homo sapiens_hsa040241.06423870
47* Type I diabetes mellitus_Homo sapiens_hsa049401.03204626
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03173747
49Type II diabetes mellitus_Homo sapiens_hsa049301.01876944
50GnRH signaling pathway_Homo sapiens_hsa049120.99613669
51Regulation of autophagy_Homo sapiens_hsa041400.92747649
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92586230
53Parkinsons disease_Homo sapiens_hsa050120.92150605
54Estrogen signaling pathway_Homo sapiens_hsa049150.91638611
55Alzheimers disease_Homo sapiens_hsa050100.91508911
56Phototransduction_Homo sapiens_hsa047440.87490938
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86716072
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84719458
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82031461
60* Butanoate metabolism_Homo sapiens_hsa006500.81176505
61Glioma_Homo sapiens_hsa052140.78909902
62ErbB signaling pathway_Homo sapiens_hsa040120.78200710
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.77287602
64Rheumatoid arthritis_Homo sapiens_hsa053230.77229188
65Fatty acid biosynthesis_Homo sapiens_hsa000610.75251848
66Melanogenesis_Homo sapiens_hsa049160.71879281
67Axon guidance_Homo sapiens_hsa043600.71425027
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66710075
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66451169
70Shigellosis_Homo sapiens_hsa051310.65955626
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65516480
72Thyroid hormone synthesis_Homo sapiens_hsa049180.65507305
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63258685
74Dilated cardiomyopathy_Homo sapiens_hsa054140.63039661
75Oocyte meiosis_Homo sapiens_hsa041140.62195820
76Pancreatic secretion_Homo sapiens_hsa049720.59553148
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58966481
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58601739
79Alcoholism_Homo sapiens_hsa050340.57418480
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56733523
81Selenocompound metabolism_Homo sapiens_hsa004500.54836783
82MAPK signaling pathway_Homo sapiens_hsa040100.54622796
83Huntingtons disease_Homo sapiens_hsa050160.53461759
84Phagosome_Homo sapiens_hsa041450.51323360
85Glucagon signaling pathway_Homo sapiens_hsa049220.49819790
86RNA polymerase_Homo sapiens_hsa030200.49753505
87Basal transcription factors_Homo sapiens_hsa030220.49744245
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49564980
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.46562304
90Ether lipid metabolism_Homo sapiens_hsa005650.46137602
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45978480
92AMPK signaling pathway_Homo sapiens_hsa041520.44291986
93Fanconi anemia pathway_Homo sapiens_hsa034600.43953986
94Salmonella infection_Homo sapiens_hsa051320.43874396
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43569433
96Ras signaling pathway_Homo sapiens_hsa040140.42800686
97Pyruvate metabolism_Homo sapiens_hsa006200.42791425
98Rap1 signaling pathway_Homo sapiens_hsa040150.42340067
99Inositol phosphate metabolism_Homo sapiens_hsa005620.40275037
100mRNA surveillance pathway_Homo sapiens_hsa030150.39767050
101Choline metabolism in cancer_Homo sapiens_hsa052310.39709988
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38176676
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36948738
104Peroxisome_Homo sapiens_hsa041460.35504904
105Hippo signaling pathway_Homo sapiens_hsa043900.34065044
106Dorso-ventral axis formation_Homo sapiens_hsa043200.33803288
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33748884
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33068124
109Fatty acid elongation_Homo sapiens_hsa000620.32698051
110Nitrogen metabolism_Homo sapiens_hsa009100.32433616
111Arginine biosynthesis_Homo sapiens_hsa002200.31769089
112Ovarian steroidogenesis_Homo sapiens_hsa049130.31369127
113Bile secretion_Homo sapiens_hsa049760.30456593
114RNA degradation_Homo sapiens_hsa030180.29588026
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29489672
116Melanoma_Homo sapiens_hsa052180.29103060
117mTOR signaling pathway_Homo sapiens_hsa041500.28622259
118Endocytosis_Homo sapiens_hsa041440.28221163
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28205103
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28092973
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27608365
122ABC transporters_Homo sapiens_hsa020100.27093246
123Fatty acid metabolism_Homo sapiens_hsa012120.26687486
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25894332
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25749985
126Base excision repair_Homo sapiens_hsa034100.25725900
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25636657
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25193629
129Steroid biosynthesis_Homo sapiens_hsa001000.25139971
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.25021479
131Circadian rhythm_Homo sapiens_hsa047100.23458842
132Insulin signaling pathway_Homo sapiens_hsa049100.22968563
133Purine metabolism_Homo sapiens_hsa002300.21984613
134Endometrial cancer_Homo sapiens_hsa052130.21157768
135Linoleic acid metabolism_Homo sapiens_hsa005910.19450792

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