GAD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gamma-aminobutyric acid transport (GO:0015812)6.21942267
2vocalization behavior (GO:0071625)6.20163107
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.05892894
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.76795507
5synaptic vesicle exocytosis (GO:0016079)5.61519558
6neuron cell-cell adhesion (GO:0007158)5.29389593
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.28960233
8regulation of glutamate receptor signaling pathway (GO:1900449)5.19418462
9synaptic vesicle maturation (GO:0016188)5.17282632
10* neurotransmitter secretion (GO:0007269)5.15679952
11negative regulation of synaptic transmission, GABAergic (GO:0032229)5.15394668
12locomotory exploration behavior (GO:0035641)5.05237649
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.96373466
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.95391490
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.88453507
16neuronal action potential propagation (GO:0019227)4.84753909
17regulation of synaptic vesicle exocytosis (GO:2000300)4.70051557
18glutamate secretion (GO:0014047)4.67466161
19protein localization to synapse (GO:0035418)4.62083491
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.60384661
21layer formation in cerebral cortex (GO:0021819)4.38651614
22neuron-neuron synaptic transmission (GO:0007270)4.31223067
23regulation of neuronal synaptic plasticity (GO:0048168)4.29296475
24regulation of synapse structural plasticity (GO:0051823)4.28988422
25glutamate receptor signaling pathway (GO:0007215)4.28469626
26gamma-aminobutyric acid signaling pathway (GO:0007214)4.25774699
27neurotransmitter-gated ion channel clustering (GO:0072578)4.23369845
28regulation of synaptic vesicle transport (GO:1902803)4.21787915
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.19992216
30synaptic transmission, glutamatergic (GO:0035249)4.18850782
31exploration behavior (GO:0035640)4.06610245
32long-term memory (GO:0007616)4.04888862
33positive regulation of synapse maturation (GO:0090129)4.02027925
34* neurotransmitter transport (GO:0006836)4.00518518
35positive regulation of synaptic transmission, GABAergic (GO:0032230)3.96696931
36positive regulation of membrane potential (GO:0045838)3.92477049
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.86914052
38insulin secretion (GO:0030073)3.85989614
39positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.85796296
40dendritic spine morphogenesis (GO:0060997)3.81736812
41* regulation of neurotransmitter levels (GO:0001505)3.79040191
42striatum development (GO:0021756)3.74779758
43negative regulation of cytosolic calcium ion concentration (GO:0051481)3.70595370
44neuron recognition (GO:0008038)3.69992820
45regulation of synaptic transmission, GABAergic (GO:0032228)3.69452386
46transmission of nerve impulse (GO:0019226)3.68932264
47prepulse inhibition (GO:0060134)3.68722577
48synaptic vesicle docking involved in exocytosis (GO:0016081)3.68526792
49regulation of synaptic transmission, glutamatergic (GO:0051966)3.66537047
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.65868554
51startle response (GO:0001964)3.65291704
52positive regulation of amino acid transport (GO:0051957)3.62726155
53regulation of postsynaptic membrane potential (GO:0060078)3.60613223
54negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.59255611
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.58317252
56proline transport (GO:0015824)3.55878105
57chemosensory behavior (GO:0007635)3.53008109
58regulation of dendritic spine morphogenesis (GO:0061001)3.51540504
59glycine transport (GO:0015816)3.51385950
60response to auditory stimulus (GO:0010996)3.50106593
61cerebellar Purkinje cell differentiation (GO:0021702)3.46555921
62response to histamine (GO:0034776)3.46085888
63auditory behavior (GO:0031223)3.46029327
64positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.45603787
65neuromuscular process controlling posture (GO:0050884)3.44118739
66activation of protein kinase A activity (GO:0034199)3.42824191
67glycerophospholipid catabolic process (GO:0046475)3.40581079
68synapse assembly (GO:0007416)3.40129004
69learning (GO:0007612)3.37789110
70membrane hyperpolarization (GO:0060081)3.37533992
71regulation of synaptic plasticity (GO:0048167)3.35932096
72detection of calcium ion (GO:0005513)3.35732646
73behavioral response to cocaine (GO:0048148)3.34885805
74regulation of calcium ion-dependent exocytosis (GO:0017158)3.32830800
75long-term synaptic potentiation (GO:0060291)3.32451193
76presynaptic membrane assembly (GO:0097105)3.32336185
77regulation of synapse maturation (GO:0090128)3.31668185
78regulation of vesicle fusion (GO:0031338)3.30443176
79intraspecies interaction between organisms (GO:0051703)3.25820008
80social behavior (GO:0035176)3.25820008
81regulation of neurotransmitter secretion (GO:0046928)3.23766677
82cellular potassium ion homeostasis (GO:0030007)3.22712478
83alanine transport (GO:0032328)3.21810135
84regulation of type B pancreatic cell apoptotic process (GO:2000674)3.20806611
85glycosphingolipid biosynthetic process (GO:0006688)3.18962682
86axonal fasciculation (GO:0007413)3.18836619
87synaptic transmission, dopaminergic (GO:0001963)3.18742279
88neuronal ion channel clustering (GO:0045161)3.18272155
89postsynaptic membrane organization (GO:0001941)3.18233563
90regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.17496787
91membrane depolarization (GO:0051899)3.17259396
92* synaptic transmission (GO:0007268)3.13008904
93regulation of neurotransmitter transport (GO:0051588)3.12805689
94mating behavior (GO:0007617)3.12226803
95regulation of glutamate secretion (GO:0014048)3.11176046
96presynaptic membrane organization (GO:0097090)3.10457302
97regulation of female receptivity (GO:0045924)3.10313251
98regulation of protein kinase A signaling (GO:0010738)3.07329258
99neuromuscular process controlling balance (GO:0050885)3.05744232
100positive regulation of synaptic transmission (GO:0050806)3.03694158
101nitric oxide mediated signal transduction (GO:0007263)3.03480397
102female mating behavior (GO:0060180)3.02065267
103adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.01524856
104* signal release (GO:0023061)3.00669619
105positive regulation of synapse assembly (GO:0051965)2.99730669
106positive regulation of neurotransmitter transport (GO:0051590)2.99540471
107synapse organization (GO:0050808)2.99297209
108endocrine pancreas development (GO:0031018)2.99087666
109nucleobase catabolic process (GO:0046113)2.98886320
110regulation of synaptic transmission (GO:0050804)2.98386608
111negative regulation of dendrite development (GO:2000171)2.97501345
112behavioral defense response (GO:0002209)2.96777165
113behavioral fear response (GO:0001662)2.96777165
114cellular ketone body metabolic process (GO:0046950)2.94197264
115serotonin metabolic process (GO:0042428)2.92071281
116membrane depolarization during action potential (GO:0086010)2.90426419
117positive regulation of neurotransmitter secretion (GO:0001956)2.89366711
118negative regulation of hormone biosynthetic process (GO:0032353)2.88459459
119potassium ion homeostasis (GO:0055075)2.87913118
120positive regulation of glycolytic process (GO:0045821)2.85945600
121righting reflex (GO:0060013)2.84768075
122peptide hormone secretion (GO:0030072)2.83111658
123innervation (GO:0060384)2.82302811
124calcium ion import (GO:0070509)2.82299531
125inositol phosphate catabolic process (GO:0071545)2.80757224
126cAMP-mediated signaling (GO:0019933)2.79221915
127positive regulation of insulin secretion (GO:0032024)2.79049778
128response to dietary excess (GO:0002021)2.78211010
129regulation of insulin secretion (GO:0050796)2.77819983
130dendritic spine organization (GO:0097061)2.77275806
131calcium ion-dependent exocytosis (GO:0017156)2.76981890
132macroautophagy (GO:0016236)2.75493775
133peptide secretion (GO:0002790)2.71677123
134cochlea development (GO:0090102)2.70112410
135regulation of glucokinase activity (GO:0033131)2.68882273
136regulation of hexokinase activity (GO:1903299)2.68882273
137pyrimidine nucleobase catabolic process (GO:0006208)2.68521696
138negative regulation of dendrite morphogenesis (GO:0050774)2.66583406
139primary amino compound metabolic process (GO:1901160)2.64311109
140positive regulation of peptide hormone secretion (GO:0090277)2.64099632
141synaptic vesicle endocytosis (GO:0048488)2.64088568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.98200013
2GBX2_23144817_ChIP-Seq_PC3_Human3.77085670
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.28948776
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.22755978
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.14427556
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07372505
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.69966386
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65516657
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65516657
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65309924
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62047833
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.61143054
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60246557
14* RARB_27405468_Chip-Seq_BRAIN_Mouse2.50705233
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48002004
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45810559
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44628284
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43832713
19DROSHA_22980978_ChIP-Seq_HELA_Human2.29044506
20* EED_16625203_ChIP-ChIP_MESCs_Mouse2.26130447
21TAF15_26573619_Chip-Seq_HEK293_Human2.23683672
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22006205
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.20150680
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.19092915
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14436823
26AR_21572438_ChIP-Seq_LNCaP_Human2.11849315
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11672980
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11670304
29* RNF2_27304074_Chip-Seq_ESCs_Mouse2.11126640
30IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04879564
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92056019
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86691555
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80227856
34SMAD4_21799915_ChIP-Seq_A2780_Human1.77260001
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69306569
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67695929
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61707995
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59503822
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57153913
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.56297173
41* P300_19829295_ChIP-Seq_ESCs_Human1.50665324
42* CBX2_27304074_Chip-Seq_ESCs_Mouse1.47727833
43ZNF274_21170338_ChIP-Seq_K562_Hela1.47100032
44IGF1R_20145208_ChIP-Seq_DFB_Human1.42960081
45* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41934930
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41522778
47* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40996563
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.38930920
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.38486484
50* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37322687
51* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37031029
52AR_25329375_ChIP-Seq_VCAP_Human1.35083401
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34769705
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.33400280
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32492631
56HTT_18923047_ChIP-ChIP_STHdh_Human1.30606760
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.30513101
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.30379687
59* NANOG_18555785_Chip-Seq_ESCs_Mouse1.29042977
60RNF2_27304074_Chip-Seq_NSC_Mouse1.28779130
61* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26318960
62* RING1B_27294783_Chip-Seq_ESCs_Mouse1.25141550
63* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24998320
64STAT3_23295773_ChIP-Seq_U87_Human1.23309295
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22461972
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21885141
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20266122
68FUS_26573619_Chip-Seq_HEK293_Human1.18374646
69* CBP_20019798_ChIP-Seq_JUKART_Human1.18362411
70* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18362411
71* AR_19668381_ChIP-Seq_PC3_Human1.18049313
72* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17135972
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16029815
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15868132
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13307927
76* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11735230
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11532157
78* P53_22387025_ChIP-Seq_ESCs_Mouse1.11364399
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11129113
80RUNX2_22187159_ChIP-Seq_PCA_Human1.10282575
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10177694
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10009279
83* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09364617
84TP53_22573176_ChIP-Seq_HFKS_Human1.09240982
85TCF4_23295773_ChIP-Seq_U87_Human1.08778925
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.08259372
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07697446
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07158996
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06957281
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06563993
91ER_23166858_ChIP-Seq_MCF-7_Human1.06514775
92* CMYC_18555785_Chip-Seq_ESCs_Mouse1.05861859
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05736185
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05302823
95* RING1B_27294783_Chip-Seq_NPCs_Mouse1.04908366
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04848960
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03476840
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03277107
99JUN_21703547_ChIP-Seq_K562_Human1.02425635
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01763387
101* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00103047
102WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99714363
103* E2F1_18555785_Chip-Seq_ESCs_Mouse0.99323383
104AHR_22903824_ChIP-Seq_MCF-7_Human0.99021526
105TAL1_26923725_Chip-Seq_HPCs_Mouse0.98966252
106ARNT_22903824_ChIP-Seq_MCF-7_Human0.98874028
107SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98744186
108* SOX2_18555785_Chip-Seq_ESCs_Mouse0.96581854
109STAT3_18555785_Chip-Seq_ESCs_Mouse0.96553521
110SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96299157
111KDM2B_26808549_Chip-Seq_REH_Human0.95646179
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95579430
113TCF4_22108803_ChIP-Seq_LS180_Human0.94706379
114PRDM14_20953172_ChIP-Seq_ESCs_Human0.93943932
115TP53_18474530_ChIP-ChIP_U2OS_Human0.90085758
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89299344
117* SMAD4_21741376_ChIP-Seq_HESCs_Human0.87789171
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87773638
119BCAT_22108803_ChIP-Seq_LS180_Human0.86868626
120* SMAD3_21741376_ChIP-Seq_ESCs_Human0.86316813
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85249712
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85249712
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84871223
124* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83600243
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83152585
126* SMAD4_21741376_ChIP-Seq_EPCs_Human0.82994040
127* SMAD3_21741376_ChIP-Seq_HESCs_Human0.82898877
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82856482

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.87911597
2* MP0003635_abnormal_synaptic_transmissio4.18985932
3MP0003880_abnormal_central_pattern4.08777206
4MP0002822_catalepsy4.07527015
5MP0009745_abnormal_behavioral_response3.83235884
6* MP0002064_seizures3.45375233
7* MP0009046_muscle_twitch3.44018313
8MP0002063_abnormal_learning/memory/cond3.40072110
9* MP0002572_abnormal_emotion/affect_behav2.97615240
10MP0004270_analgesia2.95745858
11MP0001968_abnormal_touch/_nociception2.87579044
12MP0001486_abnormal_startle_reflex2.81073677
13MP0002272_abnormal_nervous_system2.79570981
14MP0005423_abnormal_somatic_nervous2.67576038
15MP0002734_abnormal_mechanical_nocicepti2.54524625
16MP0001501_abnormal_sleep_pattern2.38561307
17MP0003195_calcinosis2.36035820
18MP0001529_abnormal_vocalization2.11472895
19MP0002735_abnormal_chemical_nociception2.10410085
20MP0008877_abnormal_DNA_methylation2.07194554
21MP0002733_abnormal_thermal_nociception2.05411412
22MP0001984_abnormal_olfaction2.04342485
23MP0001440_abnormal_grooming_behavior1.99503207
24MP0002067_abnormal_sensory_capabilities1.97966951
25MP0002736_abnormal_nociception_after1.97538692
26MP0008569_lethality_at_weaning1.96937549
27MP0005646_abnormal_pituitary_gland1.95207282
28MP0001970_abnormal_pain_threshold1.93332909
29MP0006276_abnormal_autonomic_nervous1.86424855
30* MP0002557_abnormal_social/conspecific_i1.86367717
31MP0005386_behavior/neurological_phenoty1.85056350
32MP0004924_abnormal_behavior1.85056350
33MP0002184_abnormal_innervation1.83432699
34MP0005379_endocrine/exocrine_gland_phen1.74009945
35MP0002909_abnormal_adrenal_gland1.73968917
36MP0001188_hyperpigmentation1.73846276
37MP0003122_maternal_imprinting1.72986637
38MP0003787_abnormal_imprinting1.71363659
39MP0004811_abnormal_neuron_physiology1.65803137
40MP0001944_abnormal_pancreas_morphology1.63666681
41MP0000778_abnormal_nervous_system1.61854659
42MP0009780_abnormal_chondrocyte_physiolo1.56362580
43MP0002102_abnormal_ear_morphology1.54595479
44MP0005645_abnormal_hypothalamus_physiol1.53653636
45* MP0002693_abnormal_pancreas_physiology1.50215134
46MP0003329_amyloid_beta_deposits1.50046770
47MP0002066_abnormal_motor_capabilities/c1.44182558
48MP0000013_abnormal_adipose_tissue1.44066456
49MP0004885_abnormal_endolymph1.43374588
50MP0004142_abnormal_muscle_tone1.39851332
51MP0000955_abnormal_spinal_cord1.39530613
52MP0001986_abnormal_taste_sensitivity1.38939602
53MP0003879_abnormal_hair_cell1.34080110
54MP0002882_abnormal_neuron_morphology1.33220721
55MP0002163_abnormal_gland_morphology1.32474404
56MP0001905_abnormal_dopamine_level1.31838148
57MP0004858_abnormal_nervous_system1.30161402
58MP0006072_abnormal_retinal_apoptosis1.25609214
59MP0001502_abnormal_circadian_rhythm1.25071707
60MP0001177_atelectasis1.24871706
61MP0002837_dystrophic_cardiac_calcinosis1.15864518
62MP0002638_abnormal_pupillary_reflex1.14749538
63MP0008872_abnormal_physiological_respon1.11562974
64MP0010234_abnormal_vibrissa_follicle1.08022345
65MP0002152_abnormal_brain_morphology1.07490134
66* MP0002078_abnormal_glucose_homeostasis1.06477042
67MP0005394_taste/olfaction_phenotype1.05922379
68MP0005499_abnormal_olfactory_system1.05922379
69MP0003633_abnormal_nervous_system1.05468937
70MP0005220_abnormal_exocrine_pancreas1.03094399
71MP0002069_abnormal_eating/drinking_beha1.00335732
72MP0008874_decreased_physiological_sensi0.99656444
73MP0004043_abnormal_pH_regulation0.96898378
74MP0003631_nervous_system_phenotype0.96716944
75MP0000751_myopathy0.95443203
76MP0005253_abnormal_eye_physiology0.94921379
77MP0005551_abnormal_eye_electrophysiolog0.92703197
78MP0005448_abnormal_energy_balance0.92009747
79MP0004085_abnormal_heartbeat0.91260330
80MP0002928_abnormal_bile_duct0.90110707
81MP0002229_neurodegeneration0.89183612
82MP0004510_myositis0.89039434
83MP0010386_abnormal_urinary_bladder0.88841962
84MP0003172_abnormal_lysosome_physiology0.87584185
85MP0005187_abnormal_penis_morphology0.85789435
86MP0004742_abnormal_vestibular_system0.83713520
87MP0001270_distended_abdomen0.83071821
88MP0005535_abnormal_body_temperature0.81880140
89MP0003953_abnormal_hormone_level0.80205914
90MP0003690_abnormal_glial_cell0.79971001
91MP0005409_darkened_coat_color0.79818218
92MP0002090_abnormal_vision0.78624245
93MP0003632_abnormal_nervous_system0.78149815
94MP0001963_abnormal_hearing_physiology0.78027561
95MP0003121_genomic_imprinting0.77081492
96MP0004484_altered_response_of0.76384005
97MP0004215_abnormal_myocardial_fiber0.76073496
98MP0003137_abnormal_impulse_conducting0.75933888
99MP0001765_abnormal_ion_homeostasis0.75160116
100MP0000631_abnormal_neuroendocrine_gland0.74767142
101MP0003634_abnormal_glial_cell0.73776234
102MP0002876_abnormal_thyroid_physiology0.73520807
103MP0001756_abnormal_urination0.72763134
104MP0000569_abnormal_digit_pigmentation0.71124097
105MP0002752_abnormal_somatic_nervous0.71077380
106MP0004133_heterotaxia0.70418657
107MP0000003_abnormal_adipose_tissue0.69893566
108MP0010329_abnormal_lipoprotein_level0.69341910
109MP0003011_delayed_dark_adaptation0.68586344
110MP0003868_abnormal_feces_composition0.67798299
111MP0005167_abnormal_blood-brain_barrier0.67232741
112MP0008961_abnormal_basal_metabolism0.65423542
113MP0000920_abnormal_myelination0.64397327
114MP0001943_abnormal_respiration0.63534217
115MP0004145_abnormal_muscle_electrophysio0.61905326
116MP0004233_abnormal_muscle_weight0.61715429
117MP0000604_amyloidosis0.58793348
118MP0003123_paternal_imprinting0.56614103
119MP0003646_muscle_fatigue0.56092059
120MP0003283_abnormal_digestive_organ0.55581599
121MP0010770_preweaning_lethality0.54912037
122MP0002082_postnatal_lethality0.54912037
123MP0010769_abnormal_survival0.53143365
124MP0001664_abnormal_digestion0.51481703
125MP0003861_abnormal_nervous_system0.50252499
126MP0010768_mortality/aging0.49502072
127MP0001485_abnormal_pinna_reflex0.48386155

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.00766382
2Focal seizures (HP:0007359)6.05343579
3Myokymia (HP:0002411)5.95474407
4Atonic seizures (HP:0010819)5.50158997
5Febrile seizures (HP:0002373)5.33884688
6Hypoglycemic seizures (HP:0002173)5.21134098
7Hyperinsulinemic hypoglycemia (HP:0000825)4.88590374
8Visual hallucinations (HP:0002367)4.87049832
9Epileptic encephalopathy (HP:0200134)4.86387488
10Absence seizures (HP:0002121)4.66254034
11Hypoglycemic coma (HP:0001325)4.50561320
12Progressive cerebellar ataxia (HP:0002073)4.33670717
13Hyperventilation (HP:0002883)4.24843825
14Dialeptic seizures (HP:0011146)4.23937939
15Generalized tonic-clonic seizures (HP:0002069)4.05940578
16Progressive inability to walk (HP:0002505)4.05238757
17Ketoacidosis (HP:0001993)4.02730118
18Broad-based gait (HP:0002136)3.54813843
19Poor eye contact (HP:0000817)3.51279943
20Gaze-evoked nystagmus (HP:0000640)3.48521317
21Dysdiadochokinesis (HP:0002075)3.46866073
22Abnormal social behavior (HP:0012433)3.45136584
23Impaired social interactions (HP:0000735)3.45136584
24Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.45086790
25Hyperglycemia (HP:0003074)3.39463629
26Truncal ataxia (HP:0002078)3.22300538
27Abnormality of endocrine pancreas physiology (HP:0012093)3.21768113
28Abnormality of the pancreatic islet cells (HP:0006476)3.21768113
29Insulin-resistant diabetes mellitus (HP:0000831)3.21071086
30Symptomatic seizures (HP:0011145)3.20993497
31Depression (HP:0000716)3.17448699
32Anxiety (HP:0000739)3.16194242
33Large for gestational age (HP:0001520)3.15868138
34Abnormal eating behavior (HP:0100738)3.14008152
35Increased circulating renin level (HP:0000848)3.05013239
36Action tremor (HP:0002345)2.99890717
37Mutism (HP:0002300)2.97717030
38Late onset (HP:0003584)2.93377486
39Ankle clonus (HP:0011448)2.85822818
40Impaired vibration sensation in the lower limbs (HP:0002166)2.82066408
41Dysmetria (HP:0001310)2.81532449
42Limb dystonia (HP:0002451)2.79801064
43Supranuclear gaze palsy (HP:0000605)2.79660816
44Polyphagia (HP:0002591)2.79190778
45Genetic anticipation (HP:0003743)2.78924014
46Hypomagnesemia (HP:0002917)2.78038633
47Prominent metopic ridge (HP:0005487)2.76861647
48Inability to walk (HP:0002540)2.76421967
49Scanning speech (HP:0002168)2.75881911
50Urinary bladder sphincter dysfunction (HP:0002839)2.73497291
51Status epilepticus (HP:0002133)2.72479607
52Drooling (HP:0002307)2.70806453
53Excessive salivation (HP:0003781)2.70806453
54Absent speech (HP:0001344)2.69843397
55Ketosis (HP:0001946)2.68695134
56Amblyopia (HP:0000646)2.68451833
57Abnormality of the metopic suture (HP:0005556)2.67368190
58Epileptiform EEG discharges (HP:0011182)2.65914761
59Papilledema (HP:0001085)2.63172866
60Muscular hypotonia of the trunk (HP:0008936)2.62679436
61Postural instability (HP:0002172)2.61476953
62EEG with generalized epileptiform discharges (HP:0011198)2.58658012
63Medial flaring of the eyebrow (HP:0010747)2.54196497
64Hypsarrhythmia (HP:0002521)2.52186142
65Generalized myoclonic seizures (HP:0002123)2.50208842
66Focal dystonia (HP:0004373)2.48370070
67Diplopia (HP:0000651)2.45129643
68Abnormality of binocular vision (HP:0011514)2.45129643
69Fetal akinesia sequence (HP:0001989)2.44506862
70Hemiparesis (HP:0001269)2.44152582
71Torticollis (HP:0000473)2.40152542
72Stereotypic behavior (HP:0000733)2.39482239
73Urinary urgency (HP:0000012)2.34046305
74Hemiplegia (HP:0002301)2.33652056
75Annular pancreas (HP:0001734)2.31262148
76Abnormality of calcium-phosphate metabolism (HP:0100530)2.30949966
77Impaired smooth pursuit (HP:0007772)2.30116268
78Dysmetric saccades (HP:0000641)2.29798163
79Pheochromocytoma (HP:0002666)2.27173668
80Hypothermia (HP:0002045)2.26408252
81Resting tremor (HP:0002322)2.22821065
82Enlarged penis (HP:0000040)2.22722946
83Bradykinesia (HP:0002067)2.22353679
84Specific learning disability (HP:0001328)2.21670269
85Gait imbalance (HP:0002141)2.18962348
86Abnormality of magnesium homeostasis (HP:0004921)2.18903346
87Intention tremor (HP:0002080)2.18901465
88Agitation (HP:0000713)2.16527332
89Nephrogenic diabetes insipidus (HP:0009806)2.14373482
90Spastic gait (HP:0002064)2.13125478
91Protruding tongue (HP:0010808)2.13018250
92Hyperthyroidism (HP:0000836)2.12940798
93Pancreatic islet-cell hyperplasia (HP:0004510)2.09023487
94Spastic tetraplegia (HP:0002510)2.06039460
95Failure to thrive in infancy (HP:0001531)2.05962451
96Hyperphosphatemia (HP:0002905)2.05843762
97Abnormal hair whorl (HP:0010721)2.05210900
98Blue irides (HP:0000635)2.05147993
99Hepatoblastoma (HP:0002884)2.04635397
100Craniofacial dystonia (HP:0012179)2.03234333
101Gait ataxia (HP:0002066)2.02983205
102Neurofibrillary tangles (HP:0002185)2.01845432
103Neuronal loss in central nervous system (HP:0002529)2.00757887
104Postural tremor (HP:0002174)1.98566945
105Polydipsia (HP:0001959)1.97806622
106Abnormal drinking behavior (HP:0030082)1.97806622
107Cerebral hypomyelination (HP:0006808)1.96846915
108Abnormality of ocular smooth pursuit (HP:0000617)1.96472239
109Psychosis (HP:0000709)1.93442040
110Neuroendocrine neoplasm (HP:0100634)1.93212471
111Akinesia (HP:0002304)1.90044767
112Thickened helices (HP:0000391)1.88597008
113Impaired vibratory sensation (HP:0002495)1.87645141
114Congenital malformation of the right heart (HP:0011723)1.86303380
115Double outlet right ventricle (HP:0001719)1.86303380
116Congenital primary aphakia (HP:0007707)1.85947978
117Abnormality of the corticospinal tract (HP:0002492)1.85355263
118Ankyloglossia (HP:0010296)1.84915221
119Cerebral inclusion bodies (HP:0100314)1.84618737
120Lissencephaly (HP:0001339)1.84035046
121Ventricular fibrillation (HP:0001663)1.83648707
122Insidious onset (HP:0003587)1.82231113
123Termporal pattern (HP:0011008)1.82231113
124Lower limb muscle weakness (HP:0007340)1.82143576
125Abnormality of aromatic amino acid family metabolism (HP:0004338)1.81934774
126Poor suck (HP:0002033)1.81852561
127Sleep apnea (HP:0010535)1.80705996
128Abnormality of the lower motor neuron (HP:0002366)1.80375581
129Esotropia (HP:0000565)1.80260886
130Congenital stationary night blindness (HP:0007642)1.78694762
131Pointed chin (HP:0000307)1.78329917
132Tetraplegia (HP:0002445)1.77945184
133Abnormal pancreas size (HP:0012094)1.77587369
134Generalized hypotonia (HP:0001290)1.77242315
135Diminished movement (HP:0002374)1.76971731
136Neoplasm of the peripheral nervous system (HP:0100007)1.76812832
137Amyotrophic lateral sclerosis (HP:0007354)1.76622184
138Intestinal atresia (HP:0011100)1.76175619
139Abnormality of salivation (HP:0100755)1.76072243
140Lower limb asymmetry (HP:0100559)1.75628794
141Menstrual irregularities (HP:0000858)1.72230124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.82861212
2NTRK34.40641099
3EPHA43.91466667
4MAP3K43.75019227
5MAP3K93.52098419
6MAP2K73.38564143
7MARK12.87669697
8NTRK22.57712980
9MAP3K122.55710608
10MINK12.53932748
11MAP2K42.20232379
12CASK2.12077884
13PNCK2.03801940
14MAP4K21.87401876
15SIK21.78193479
16KSR21.77829861
17NTRK11.74828638
18PAK61.74149059
19FES1.69298041
20TNIK1.65294247
21ARAF1.65037499
22DAPK21.59941876
23KSR11.59548045
24CDK51.56878654
25RIPK41.53248402
26CAMKK11.40401870
27CSNK1G31.39395006
28PASK1.37128554
29PRKD31.35313470
30CSNK1G11.34513910
31PRKCG1.28608084
32MAP3K131.27798772
33AKT31.23670192
34GRK51.23349809
35DAPK11.22089228
36PLK21.21601522
37MAPK131.20215873
38SGK2231.19657481
39SGK4941.19657481
40SGK21.17610053
41GRK11.12310503
42UHMK11.08429910
43MAP2K61.07167151
44STK381.05211624
45MAP3K21.03928586
46ERBB41.02996293
47CSNK1A1L1.02210993
48CAMKK21.01900771
49CAMK2A1.00702528
50EPHA30.96366420
51TYRO30.93833317
52ADRBK20.92816688
53PRPF4B0.92231548
54CDK190.91566059
55LMTK20.90738165
56SGK30.89515201
57CDK140.86547735
58CDK180.85260886
59PRKCE0.85097211
60INSRR0.85096170
61CDK150.80773144
62CAMK10.80736798
63TNK20.79980515
64ERBB30.79275150
65CAMK2B0.76274368
66STK38L0.76224160
67MAP3K60.75911026
68PRKCH0.75869059
69LIMK10.75662353
70SGK10.75155976
71RAF10.75096488
72BMPR20.74358090
73TRPM70.74092856
74CSNK1G20.72604059
75PHKG10.72525872
76PHKG20.72525872
77STK110.72327469
78PRKAA10.70760421
79PINK10.69194270
80WNK30.69101493
81MUSK0.69070401
82CDK11A0.68206349
83TRIM280.66108703
84OXSR10.64877132
85SIK30.64310414
86FER0.64103595
87DYRK20.63705944
88PAK30.63131574
89FGFR30.62641848
90LATS20.62633338
91HIPK20.62034039
92SCYL20.61712187
93DYRK1A0.60659357
94PRKCZ0.58992395
95TESK10.58903227
96CSNK1A10.58047184
97MARK20.56972160
98BCR0.55996165
99BRAF0.55847668
100ALK0.55261895
101NEK60.54377463
102CAMK1G0.53363135
103FGFR20.52378098
104RET0.51964772
105MAP2K10.51325614
106RPS6KA30.50321709
107MAP3K10.48859119
108CSNK1D0.48189509
109FYN0.48092281
110PRKG10.47206968
111WNK10.46762706
112PKN10.45434581
113CCNB10.45194551
114MAPK100.45033460
115CAMK2G0.44646416
116BMPR1B0.44562314
117CAMK2D0.44487992
118CSNK1E0.44435293
119PTK2B0.44204284
120PRKCA0.40527760
121PRKACA0.39318304
122ROCK20.38947858
123CDK30.38871218
124PRKD20.38440977
125TSSK60.38362778
126TAOK10.37375090
127PDK10.37340561
128PRKCB0.37224047
129RPS6KA20.35544502
130WNK40.34645116
131CAMK40.34551881
132CDC42BPA0.33529951
133IRAK20.33377883
134PRKACB0.32956168

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.47366799
2Nicotine addiction_Homo sapiens_hsa050334.35253233
3Synaptic vesicle cycle_Homo sapiens_hsa047213.60779714
4* GABAergic synapse_Homo sapiens_hsa047273.42147994
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.98812040
6Morphine addiction_Homo sapiens_hsa050322.88410723
7Olfactory transduction_Homo sapiens_hsa047402.68222913
8Circadian entrainment_Homo sapiens_hsa047132.54396328
9Glutamatergic synapse_Homo sapiens_hsa047242.49895600
10Long-term potentiation_Homo sapiens_hsa047202.48833551
11Amphetamine addiction_Homo sapiens_hsa050312.26449344
12Collecting duct acid secretion_Homo sapiens_hsa049662.14036259
13Dopaminergic synapse_Homo sapiens_hsa047282.12942759
14Taste transduction_Homo sapiens_hsa047421.99946994
15Salivary secretion_Homo sapiens_hsa049701.96717945
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95585007
17* Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94137892
18Serotonergic synapse_Homo sapiens_hsa047261.88113151
19Insulin secretion_Homo sapiens_hsa049111.81449456
20Cholinergic synapse_Homo sapiens_hsa047251.80562877
21Cocaine addiction_Homo sapiens_hsa050301.78915198
22Long-term depression_Homo sapiens_hsa047301.78064244
23Protein export_Homo sapiens_hsa030601.70264870
24Gastric acid secretion_Homo sapiens_hsa049711.69695637
25Renin secretion_Homo sapiens_hsa049241.59800154
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54161985
27Calcium signaling pathway_Homo sapiens_hsa040201.53086174
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53035857
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51250841
30Oxytocin signaling pathway_Homo sapiens_hsa049211.50173287
31Vitamin B6 metabolism_Homo sapiens_hsa007501.39481939
32Gap junction_Homo sapiens_hsa045401.33587408
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33091374
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31598201
35Vibrio cholerae infection_Homo sapiens_hsa051101.31596486
36Cardiac muscle contraction_Homo sapiens_hsa042601.23514640
37GnRH signaling pathway_Homo sapiens_hsa049121.21558066
38Regulation of autophagy_Homo sapiens_hsa041401.20910938
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19865925
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18506702
41cAMP signaling pathway_Homo sapiens_hsa040241.17106105
42* Type I diabetes mellitus_Homo sapiens_hsa049401.09996864
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08431941
44Estrogen signaling pathway_Homo sapiens_hsa049151.03459480
45Axon guidance_Homo sapiens_hsa043601.03039737
46Oxidative phosphorylation_Homo sapiens_hsa001900.99565613
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98051835
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97941032
49Type II diabetes mellitus_Homo sapiens_hsa049300.97144475
50Melanogenesis_Homo sapiens_hsa049160.94952860
51ErbB signaling pathway_Homo sapiens_hsa040120.91968412
52* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91081671
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91055097
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88152002
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86070702
56Phototransduction_Homo sapiens_hsa047440.85701780
57* Butanoate metabolism_Homo sapiens_hsa006500.85381950
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.83298587
59Glioma_Homo sapiens_hsa052140.83059951
60Alzheimers disease_Homo sapiens_hsa050100.82991449
61Ether lipid metabolism_Homo sapiens_hsa005650.75906964
62ABC transporters_Homo sapiens_hsa020100.75595661
63Parkinsons disease_Homo sapiens_hsa050120.75362547
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74003138
65Oocyte meiosis_Homo sapiens_hsa041140.73514235
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69149902
67Thyroid hormone synthesis_Homo sapiens_hsa049180.68528986
68Sphingolipid metabolism_Homo sapiens_hsa006000.68194806
69Dilated cardiomyopathy_Homo sapiens_hsa054140.67799630
70Alcoholism_Homo sapiens_hsa050340.67698322
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66952802
72Folate biosynthesis_Homo sapiens_hsa007900.66588833
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.65407076
74Pancreatic secretion_Homo sapiens_hsa049720.64908732
75MAPK signaling pathway_Homo sapiens_hsa040100.63833060
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63703423
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60862183
78Mineral absorption_Homo sapiens_hsa049780.59975086
79Dorso-ventral axis formation_Homo sapiens_hsa043200.59096912
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55243730
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55240781
82Choline metabolism in cancer_Homo sapiens_hsa052310.55113329
83Tryptophan metabolism_Homo sapiens_hsa003800.54635709
84Sulfur metabolism_Homo sapiens_hsa009200.52077923
85Fatty acid elongation_Homo sapiens_hsa000620.51713277
86Rap1 signaling pathway_Homo sapiens_hsa040150.51254547
87Ras signaling pathway_Homo sapiens_hsa040140.50310406
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50241581
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49874413
90Selenocompound metabolism_Homo sapiens_hsa004500.47140110
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47033494
92Rheumatoid arthritis_Homo sapiens_hsa053230.46369910
93Huntingtons disease_Homo sapiens_hsa050160.44662275
94Nitrogen metabolism_Homo sapiens_hsa009100.44549129
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44419343
96Glucagon signaling pathway_Homo sapiens_hsa049220.41918841
97Peroxisome_Homo sapiens_hsa041460.41535566
98Bile secretion_Homo sapiens_hsa049760.39643094
99AMPK signaling pathway_Homo sapiens_hsa041520.38420138
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38310447
101Inositol phosphate metabolism_Homo sapiens_hsa005620.37568859
102African trypanosomiasis_Homo sapiens_hsa051430.36278961
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36091501
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.35903316
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35265414
106Fatty acid metabolism_Homo sapiens_hsa012120.34600783
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.34359856
108Linoleic acid metabolism_Homo sapiens_hsa005910.34289671
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34060539
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33963264
111Ovarian steroidogenesis_Homo sapiens_hsa049130.33782502
112Renal cell carcinoma_Homo sapiens_hsa052110.33267812
113Prion diseases_Homo sapiens_hsa050200.32697924
114Circadian rhythm_Homo sapiens_hsa047100.32518079
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31802945
116Wnt signaling pathway_Homo sapiens_hsa043100.30895007
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.30837311
118Non-small cell lung cancer_Homo sapiens_hsa052230.30706931
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30432422
120Endometrial cancer_Homo sapiens_hsa052130.29237307
121Endocytosis_Homo sapiens_hsa041440.29186444
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27394485
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26909970
124Insulin signaling pathway_Homo sapiens_hsa049100.26043152
125VEGF signaling pathway_Homo sapiens_hsa043700.24965399
126mTOR signaling pathway_Homo sapiens_hsa041500.24853354
127Propanoate metabolism_Homo sapiens_hsa006400.23241531
128* beta-Alanine metabolism_Homo sapiens_hsa004100.23220256

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