GADD45A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)7.76474971
2protoporphyrinogen IX biosynthetic process (GO:0006782)7.00102907
3glomerular visceral epithelial cell development (GO:0072015)6.05657840
4heme biosynthetic process (GO:0006783)5.19192439
5glomerular epithelial cell development (GO:0072310)5.13770379
6porphyrin-containing compound biosynthetic process (GO:0006779)5.12322779
7hemidesmosome assembly (GO:0031581)5.11968242
8skin morphogenesis (GO:0043589)4.66767033
9tetrapyrrole biosynthetic process (GO:0033014)4.40396943
10glomerular basement membrane development (GO:0032836)4.37888464
11heme metabolic process (GO:0042168)4.12209125
12erythrocyte maturation (GO:0043249)4.09925070
13porphyrin-containing compound metabolic process (GO:0006778)4.07570758
14regulation of early endosome to late endosome transport (GO:2000641)4.01695255
15cell-substrate junction assembly (GO:0007044)3.94823697
16neutrophil activation involved in immune response (GO:0002283)3.89330477
17skeletal muscle tissue regeneration (GO:0043403)3.87504557
18regulation of transforming growth factor beta1 production (GO:0032908)3.80098345
19hemoglobin metabolic process (GO:0020027)3.70490799
20protein localization to endosome (GO:0036010)3.60105762
21regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.57793035
22atrioventricular valve morphogenesis (GO:0003181)3.56241383
23response to arsenic-containing substance (GO:0046685)3.53621544
24hypotonic response (GO:0006971)3.47312131
25negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.46581976
26positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.42677010
27muscle cell fate commitment (GO:0042693)3.42293103
28production of molecular mediator involved in inflammatory response (GO:0002532)3.38054295
29wound healing, spreading of epidermal cells (GO:0035313)3.31742721
30regulation of apoptotic process involved in morphogenesis (GO:1902337)3.30451926
31desmosome organization (GO:0002934)3.29647854
32endothelial cell chemotaxis (GO:0035767)3.22579659
33hepatocyte apoptotic process (GO:0097284)3.21155745
34* positive regulation of p38MAPK cascade (GO:1900745)3.18127062
35maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.15654982
36regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.15641743
37negative regulation of homotypic cell-cell adhesion (GO:0034111)3.14104345
38positive regulation of astrocyte differentiation (GO:0048711)3.11577371
39erythrocyte development (GO:0048821)3.02558893
40cellular response to arsenic-containing substance (GO:0071243)2.99629146
41ER overload response (GO:0006983)2.99002879
42skeletal muscle contraction (GO:0003009)2.97912547
43positive regulation of endothelial cell apoptotic process (GO:2000353)2.96859698
44positive regulation of blood vessel endothelial cell migration (GO:0043536)2.96027909
45platelet aggregation (GO:0070527)2.94843077
46cell-substrate adherens junction assembly (GO:0007045)2.92889168
47focal adhesion assembly (GO:0048041)2.92889168
48ribosomal small subunit biogenesis (GO:0042274)2.92459433
49endocytic recycling (GO:0032456)2.91278696
50angiogenesis involved in wound healing (GO:0060055)2.90943139
51Golgi transport vesicle coating (GO:0048200)2.89516010
52COPI coating of Golgi vesicle (GO:0048205)2.89516010
53negative regulation of fatty acid biosynthetic process (GO:0045717)2.88574118
54positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.87417672
55trophoblast giant cell differentiation (GO:0060707)2.85524492
56platelet degranulation (GO:0002576)2.85039387
57peptidyl-proline hydroxylation (GO:0019511)2.84668060
58actin-myosin filament sliding (GO:0033275)2.83627489
59muscle filament sliding (GO:0030049)2.83627489
60protein neddylation (GO:0045116)2.81559983
61stress fiber assembly (GO:0043149)2.81526910
62regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.81419961
63mRNA transcription (GO:0009299)2.81367320
64regulation of transforming growth factor beta2 production (GO:0032909)2.80755762
65cell adhesion mediated by integrin (GO:0033627)2.80351769
66endodermal cell differentiation (GO:0035987)2.79118457
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.78315246
68membrane raft organization (GO:0031579)2.77718240
69negative regulation of erythrocyte differentiation (GO:0045647)2.77658495
70adherens junction assembly (GO:0034333)2.74576318
71adhesion of symbiont to host (GO:0044406)2.73983153
72protein hydroxylation (GO:0018126)2.72462364
73erythrocyte differentiation (GO:0030218)2.72442360
74* regulation of p38MAPK cascade (GO:1900744)2.72359748
75epithelial cell-cell adhesion (GO:0090136)2.71355648
76granulocyte activation (GO:0036230)2.70029095
77decidualization (GO:0046697)2.69968331
78L-alpha-amino acid transmembrane transport (GO:1902475)2.69690012
79endoplasmic reticulum unfolded protein response (GO:0030968)2.68517137
80fibrinolysis (GO:0042730)2.68294647
81skeletal muscle fiber development (GO:0048741)2.67348329
82sequestering of metal ion (GO:0051238)2.67091685
83activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.66986102
84neutrophil activation (GO:0042119)2.66731623
85embryonic process involved in female pregnancy (GO:0060136)2.64864925
86negative regulation of protein localization to cell surface (GO:2000009)2.63788055
87hydrogen peroxide biosynthetic process (GO:0050665)2.63468890
88positive regulation of adherens junction organization (GO:1903393)2.63364306
89skeletal muscle adaptation (GO:0043501)2.61981468
90positive regulation of protein oligomerization (GO:0032461)2.61328252
91positive regulation of nuclease activity (GO:0032075)2.60361725
92tetrapyrrole metabolic process (GO:0033013)2.60031140
93iron ion import (GO:0097286)2.57952207
94mammary gland epithelial cell proliferation (GO:0033598)2.54782402
95regulation of metalloenzyme activity (GO:0048552)2.54534338
96response to peptidoglycan (GO:0032494)2.54297842
97ovulation from ovarian follicle (GO:0001542)2.53540137
98ER-nucleus signaling pathway (GO:0006984)2.53044080
99protein retention in ER lumen (GO:0006621)2.52774303
100cellular response to unfolded protein (GO:0034620)2.52720561
101protein targeting to plasma membrane (GO:0072661)2.52473939
102striated muscle atrophy (GO:0014891)2.51123827
103interferon-gamma secretion (GO:0072643)2.50998545
104positive regulation of odontogenesis (GO:0042482)2.50979459
105mesodermal cell differentiation (GO:0048333)2.50626947
106low-density lipoprotein particle clearance (GO:0034383)2.50302865
107endocardial cushion development (GO:0003197)2.49279685
108intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.48596079
109positive regulation of extracellular matrix organization (GO:1903055)2.47577210
110regulation of vitamin D biosynthetic process (GO:0060556)2.47031196
111regulation of integrin activation (GO:0033623)2.46485970
1123-UTR-mediated mRNA stabilization (GO:0070935)2.44425438
113positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.44223269
114cellular response to vitamin (GO:0071295)2.42363458
115positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.42029284
116actin-mediated cell contraction (GO:0070252)2.41552920
117regulation of translational termination (GO:0006449)2.39712618
118respiratory burst (GO:0045730)2.39295053
119negative regulation of focal adhesion assembly (GO:0051895)2.38578380
120negative regulation of cell junction assembly (GO:1901889)2.38578380
121negative regulation of adherens junction organization (GO:1903392)2.38578380
122SMAD protein complex assembly (GO:0007183)2.38564199
123vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.37987202
124reactive oxygen species biosynthetic process (GO:1903409)2.37794507
125extracellular fibril organization (GO:0043206)2.37564421
126wound healing, spreading of cells (GO:0044319)2.36904328
127positive regulation of focal adhesion assembly (GO:0051894)2.36420402
128positive regulation of cell junction assembly (GO:1901890)2.36420402
129hyaluronan catabolic process (GO:0030214)2.35877918
130response to UV-C (GO:0010225)2.35872648
131negative regulation of fatty acid transport (GO:2000192)2.35626014
132heart trabecula formation (GO:0060347)2.35008963
133positive regulation of receptor recycling (GO:0001921)2.34794353
134muscle cell migration (GO:0014812)2.33956151
135cellular response to topologically incorrect protein (GO:0035967)2.32961285
136Arp2/3 complex-mediated actin nucleation (GO:0034314)2.32545601
137mRNA transcription from RNA polymerase II promoter (GO:0042789)2.31591177
138regulation of protein heterodimerization activity (GO:0043497)2.31554355
139IMP biosynthetic process (GO:0006188)2.30982831
140leukocyte aggregation (GO:0070486)2.30464917
141regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.30432204
142muscle atrophy (GO:0014889)2.29479863
143pattern specification involved in kidney development (GO:0061004)2.29090140
144negative regulation of necroptotic process (GO:0060546)2.28941713
145virion attachment to host cell (GO:0019062)2.27948234
146adhesion of symbiont to host cell (GO:0044650)2.27948234
147positive regulation of protein homooligomerization (GO:0032464)2.27853958
148positive regulation of hemostasis (GO:1900048)2.27649624
149positive regulation of blood coagulation (GO:0030194)2.27649624
150very-low-density lipoprotein particle assembly (GO:0034379)2.22042052
151regulation of integrin-mediated signaling pathway (GO:2001044)2.21252234
152superoxide anion generation (GO:0042554)2.18908705
153negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.17517136
154RNA stabilization (GO:0043489)2.16318842
155mRNA stabilization (GO:0048255)2.16318842
156response to muramyl dipeptide (GO:0032495)2.16113800
157purine nucleotide salvage (GO:0032261)2.15943368
158intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.14402955
159cellular response to glucose starvation (GO:0042149)2.14287239
160positive regulation of erythrocyte differentiation (GO:0045648)2.14163051
161regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.13769567
162platelet formation (GO:0030220)2.12687638
163myeloid cell development (GO:0061515)2.12434703
164positive regulation of myotube differentiation (GO:0010831)2.11471274
165positive regulation of macrophage differentiation (GO:0045651)2.11153085
166basement membrane organization (GO:0071711)2.09709951
167regulation of podosome assembly (GO:0071801)2.08230103
168barbed-end actin filament capping (GO:0051016)2.08076234
169myeloid cell homeostasis (GO:0002262)2.07407296
170T cell apoptotic process (GO:0070231)2.07051853
171plasma membrane repair (GO:0001778)2.06705705
172folic acid-containing compound biosynthetic process (GO:0009396)2.06302057
173skeletal muscle tissue development (GO:0007519)2.05670520
174hydrogen peroxide catabolic process (GO:0042744)2.05565056
175positive regulation of osteoblast proliferation (GO:0033690)2.05357532
176granulocyte differentiation (GO:0030851)2.04673311
177regulation of response to osmotic stress (GO:0047484)2.04184119
178extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)2.03732501
179signal transduction in absence of ligand (GO:0038034)2.03732501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.87484104
2E2F7_22180533_ChIP-Seq_HELA_Human3.77217195
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.73671379
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.70706621
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.14485124
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.02329786
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.89652971
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.77617657
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.56091753
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48604217
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.45473358
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.31620363
13* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.19841753
14* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.17135017
15* GATA1_19941826_ChIP-Seq_K562_Human2.13814396
16BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13544558
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.09792767
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.00128190
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96660631
20SCL_19346495_ChIP-Seq_HPC-7_Human1.90937873
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90410204
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.89508853
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88191190
24* CLOCK_20551151_ChIP-Seq_293T_Human1.87901301
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.82690877
26* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.79556375
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76779655
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.73025800
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71495771
30* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.69203078
31* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.66524210
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66519735
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65971107
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.64914946
35MYC_22102868_ChIP-Seq_BL_Human1.64662310
36* ATF3_27146783_Chip-Seq_COLON_Human1.60965263
37* TP53_22127205_ChIP-Seq_IMR90_Human1.60833492
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56614796
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56408991
40* GATA2_19941826_ChIP-Seq_K562_Human1.54758987
41* ELK3_25401928_ChIP-Seq_HUVEC_Human1.53117049
42* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53108755
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.51578485
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51494696
45* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.49707575
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.48640573
47* NCOR1_26117541_ChIP-Seq_K562_Human1.47009511
48* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45522035
49* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45522035
50* VDR_21846776_ChIP-Seq_THP-1_Human1.45448147
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42876709
52* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42528189
53* TFEB_21752829_ChIP-Seq_HELA_Human1.42475621
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41973997
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41554170
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40945366
57* GATA1_19941827_ChIP-Seq_MEL_Mouse1.40580426
58TCF7_22412390_ChIP-Seq_EML_Mouse1.40266924
59GATA1_22025678_ChIP-Seq_K562_Human1.39830100
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.38738279
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38245496
62SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.36944929
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.36506642
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35474793
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34943269
66LXR_22292898_ChIP-Seq_THP-1_Human1.34754090
67* MAF_26560356_Chip-Seq_TH1_Human1.34728811
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33231073
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33123859
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32486010
71KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.31531217
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31249844
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28159139
74RXR_22158963_ChIP-Seq_LIVER_Mouse1.27490207
75* VDR_24763502_ChIP-Seq_THP-1_Human1.25600370
76* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22446336
77EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.22389195
78* KDM2B_26808549_Chip-Seq_K562_Human1.20904627
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.19611948
80* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19459569
81* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18842206
82* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18741772
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17998608
84* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17477838
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16212628
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15608597
87* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15462978
88SMC1_22415368_ChIP-Seq_MEFs_Mouse1.14407300
89* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13196668
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12491934
91NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12206228
92* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10946879
93FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.10409057
94ZNF263_19887448_ChIP-Seq_K562_Human1.10001972
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09345052
96AR_21909140_ChIP-Seq_LNCAP_Human1.08820539
97* SPI1_23547873_ChIP-Seq_NB4_Human1.08728250
98PU_27001747_Chip-Seq_BMDM_Mouse1.07527163
99* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07253676
100* KDM2B_26808549_Chip-Seq_DND41_Human1.07114729
101* UTX_26944678_Chip-Seq_JUKART_Human1.07053082
102* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06462299
103* GATA6_25053715_ChIP-Seq_YYC3_Human1.05767865
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05651033
105* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05486952
106SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05130659
107* BRD4_25478319_ChIP-Seq_HGPS_Human1.04928490
108CJUN_26792858_Chip-Seq_BT549_Human1.04857840
109E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04058924
110* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03723323
111MYB_26560356_Chip-Seq_TH2_Human1.03314015
112NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02756876
113* GATA2_21666600_ChIP-Seq_HMVEC_Human1.02069131
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01827972
115STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01094119
116ESR2_21235772_ChIP-Seq_MCF-7_Human1.01078878
117* UBF1/2_26484160_Chip-Seq_HMECs_Human1.01072718
118WT1_19549856_ChIP-ChIP_CCG9911_Human1.00979961
119* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00027205
120* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99136126
121* RACK7_27058665_Chip-Seq_MCF-7_Human0.99048845
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99036785
123* SOX2_20726797_ChIP-Seq_SW620_Human0.98735109
124MYC_18555785_ChIP-Seq_MESCs_Mouse0.96265985
125* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95840562
126SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95753906
127ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95396243
128* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94351189
129* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93175369
130RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92638109
131* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92277763
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91803813
133KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91541660
134CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90828689
135IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89480602
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86731748
137* TP53_18474530_ChIP-ChIP_U2OS_Human0.84567793
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83691746

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo4.62093361
2MP0003950_abnormal_plasma_membrane3.19477868
3MP0002877_abnormal_melanocyte_morpholog2.95280974
4MP0000678_abnormal_parathyroid_gland2.66921685
5MP0010307_abnormal_tumor_latency2.50430099
6MP0003436_decreased_susceptibility_to2.43714186
7MP0005076_abnormal_cell_differentiation2.43258659
8MP0004147_increased_porphyrin_level2.40692624
9MP0000733_abnormal_muscle_development2.31997244
10MP0010352_gastrointestinal_tract_polyps2.22117434
11MP0010368_abnormal_lymphatic_system2.02521566
12MP0005397_hematopoietic_system_phenotyp2.01597657
13MP0001545_abnormal_hematopoietic_system2.01597657
14MP0009840_abnormal_foam_cell2.00342540
15MP0008438_abnormal_cutaneous_collagen1.98928609
16MP0003566_abnormal_cell_adhesion1.97929996
17MP0008004_abnormal_stomach_pH1.97261824
18MP0000749_muscle_degeneration1.86363645
19MP0003705_abnormal_hypodermis_morpholog1.85459124
20MP0009278_abnormal_bone_marrow1.83317744
21* MP0000858_altered_metastatic_potential1.79991457
22MP0000750_abnormal_muscle_regeneration1.73991472
23* MP0005501_abnormal_skin_physiology1.73463924
24MP0000762_abnormal_tongue_morphology1.73179380
25MP0001348_abnormal_lacrimal_gland1.67131501
26MP0005257_abnormal_intraocular_pressure1.63806429
27MP0003453_abnormal_keratinocyte_physiol1.59224679
28MP0000343_altered_response_to1.59079665
29MP0006054_spinal_hemorrhage1.57942935
30MP0003300_gastrointestinal_ulcer1.57848777
31MP0000685_abnormal_immune_system1.53570962
32MP0003303_peritoneal_inflammation1.52888770
33MP0005023_abnormal_wound_healing1.52439541
34MP0009785_altered_susceptibility_to1.51723695
35MP0003448_altered_tumor_morphology1.49543370
36MP0004510_myositis1.48643566
37MP0002796_impaired_skin_barrier1.44220211
38MP0001958_emphysema1.43620443
39MP0005083_abnormal_biliary_tract1.42761937
40MP0000579_abnormal_nail_morphology1.40861041
41MP0002419_abnormal_innate_immunity1.40445595
42MP0009384_cardiac_valve_regurgitation1.38674351
43MP0001533_abnormal_skeleton_physiology1.35558452
44MP0005508_abnormal_skeleton_morphology1.34544521
45MP0005623_abnormal_meninges_morphology1.34245162
46MP0001216_abnormal_epidermal_layer1.31233425
47MP0003186_abnormal_redox_activity1.26958933
48MP0005464_abnormal_platelet_physiology1.26735918
49MP0005451_abnormal_body_composition1.26088094
50MP0004947_skin_inflammation1.25633346
51MP0002254_reproductive_system_inflammat1.24150374
52MP0002148_abnormal_hypersensitivity_rea1.21164125
53MP0009764_decreased_sensitivity_to1.20168117
54MP0000759_abnormal_skeletal_muscle1.19801564
55MP0003724_increased_susceptibility_to1.19080350
56MP0004272_abnormal_basement_membrane1.18606414
57* MP0005000_abnormal_immune_tolerance1.18036226
58MP0000747_muscle_weakness1.17551602
59MP0002405_respiratory_system_inflammati1.17166464
60MP0005165_increased_susceptibility_to1.14845268
61MP0002332_abnormal_exercise_endurance1.14747660
62MP0002138_abnormal_hepatobiliary_system1.14426659
63MP0003091_abnormal_cell_migration1.13732233
64MP0000490_abnormal_crypts_of1.13418491
65MP0009250_abnormal_appendicular_skeleto1.12648406
66* MP0010771_integument_phenotype1.12162724
67MP0005503_abnormal_tendon_morphology1.11768379
68MP0000467_abnormal_esophagus_morphology1.11365557
69MP0004233_abnormal_muscle_weight1.10860202
70MP0002166_altered_tumor_susceptibility1.10138371
71MP0004087_abnormal_muscle_fiber1.09833944
72MP0005025_abnormal_response_to1.09690008
73MP0002896_abnormal_bone_mineralization1.07723925
74MP0008007_abnormal_cellular_replicative1.05819501
75MP0005275_abnormal_skin_tensile1.05699071
76MP0000767_abnormal_smooth_muscle1.05545499
77MP0009333_abnormal_splenocyte_physiolog1.04223473
78MP0002972_abnormal_cardiac_muscle1.03015006
79MP0002295_abnormal_pulmonary_circulatio1.02351751
80MP0009379_abnormal_foot_pigmentation1.02062399
81MP0002006_tumorigenesis1.01776903
82MP0002106_abnormal_muscle_physiology1.01679966
83MP0005164_abnormal_response_to1.01363329
84MP0001835_abnormal_antigen_presentation0.99349188
85MP0003828_pulmonary_edema0.98921329
86MP0001851_eye_inflammation0.98572684
87MP0004808_abnormal_hematopoietic_stem0.98231636
88MP0002998_abnormal_bone_remodeling0.97874533
89MP0010155_abnormal_intestine_physiology0.97342028
90MP0006082_CNS_inflammation0.96586852
91MP0006138_congestive_heart_failure0.96114551
92MP0004185_abnormal_adipocyte_glucose0.94208065
93MP0005666_abnormal_adipose_tissue0.94065069
94* MP0001845_abnormal_inflammatory_respons0.93715208
95MP0004084_abnormal_cardiac_muscle0.93086653
96MP0003941_abnormal_skin_development0.91978534
97MP0005390_skeleton_phenotype0.91847474
98MP0003279_aneurysm0.91212261
99MP0000013_abnormal_adipose_tissue0.90821724
100MP0001879_abnormal_lymphatic_vessel0.89769854
101MP0000003_abnormal_adipose_tissue0.89750255
102* MP0000350_abnormal_cell_proliferation0.89500388
103MP0001915_intracranial_hemorrhage0.89011212
104MP0000516_abnormal_urinary_system0.88189040
105MP0005367_renal/urinary_system_phenotyp0.88189040
106* MP0002452_abnormal_antigen_presenting0.87999605
107MP0002060_abnormal_skin_morphology0.87785235
108MP0004197_abnormal_fetal_growth/weight/0.87535543
109* MP0002019_abnormal_tumor_incidence0.87464916
110MP0009931_abnormal_skin_appearance0.87318214
111MP0005369_muscle_phenotype0.86266065
112MP0005197_abnormal_uvea_morphology0.86078985
113MP0005058_abnormal_lysosome_morphology0.85727234
114MP0001542_abnormal_bone_strength0.85344351
115MP0003191_abnormal_cellular_cholesterol0.83352808
116MP0005375_adipose_tissue_phenotype0.83334433
117MP0002108_abnormal_muscle_morphology0.82990290
118MP0002396_abnormal_hematopoietic_system0.82952201
119MP0001790_abnormal_immune_system0.82499370
120MP0005387_immune_system_phenotype0.82499370
121MP0001849_ear_inflammation0.80896264
122MP0005330_cardiomyopathy0.79999628
123MP0002009_preneoplasia0.79341119
124* MP0002398_abnormal_bone_marrow0.79247757
125MP0002128_abnormal_blood_circulation0.78933249
126* MP0002136_abnormal_kidney_physiology0.78711808
127MP0003806_abnormal_nucleotide_metabolis0.78566780
128* MP0005621_abnormal_cell_physiology0.78091053
129MP0001881_abnormal_mammary_gland0.78071790
130* MP0003077_abnormal_cell_cycle0.77025578
131MP0008775_abnormal_heart_ventricle0.75985668
132MP0003879_abnormal_hair_cell0.75381072
133MP0005409_darkened_coat_color0.75248056
134* MP0002420_abnormal_adaptive_immunity0.74925799
135MP0008260_abnormal_autophagy0.74890688
136* MP0001819_abnormal_immune_cell0.74863550
137MP0002933_joint_inflammation0.74816392
138MP0002089_abnormal_postnatal_growth/wei0.74494384
139* MP0002722_abnormal_immune_system0.74187612
140MP0003795_abnormal_bone_structure0.73490010
141MP0000689_abnormal_spleen_morphology0.73443389
142MP0009053_abnormal_anal_canal0.72131685
143MP0003075_altered_response_to0.72105899
144MP0005193_abnormal_anterior_eye0.70853682
145MP0010030_abnormal_orbit_morphology0.69449545
146MP0000534_abnormal_ureter_morphology0.69125571
147MP0005620_abnormal_muscle_contractility0.68074017
148MP0001243_abnormal_dermal_layer0.68012814
149MP0001614_abnormal_blood_vessel0.66894745
150MP0003385_abnormal_body_wall0.66162737
151MP0000249_abnormal_blood_vessel0.65629929

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.40695260
2Muscle fiber inclusion bodies (HP:0100299)5.32562517
3Nemaline bodies (HP:0003798)5.04759792
4Type 1 muscle fiber predominance (HP:0003803)4.91513600
5Poikilocytosis (HP:0004447)4.62691293
6Ulnar deviation of the wrist (HP:0003049)4.36057504
7Abnormality of the heme biosynthetic pathway (HP:0010472)4.24293861
8Atrophic scars (HP:0001075)4.09425104
9Distal arthrogryposis (HP:0005684)3.89554517
10Hypochromic microcytic anemia (HP:0004840)3.84145037
11Aplasia of the musculature (HP:0100854)3.82032865
12Increased mean platelet volume (HP:0011877)3.78634231
13Onycholysis (HP:0001806)3.73634644
14Menorrhagia (HP:0000132)3.60825225
15Reticulocytosis (HP:0001923)3.60070231
16Popliteal pterygium (HP:0009756)3.59365950
17Round ear (HP:0100830)3.36394407
18Eczematoid dermatitis (HP:0000976)3.34203671
19Malignant hyperthermia (HP:0002047)3.30414397
20Fragile skin (HP:0001030)3.26531944
21Myopathic facies (HP:0002058)3.25604876
22Abnormal platelet volume (HP:0011876)3.25123734
23Fetal akinesia sequence (HP:0001989)3.24863094
24Abnormality of the neuromuscular junction (HP:0003398)3.24382352
25Fatigable weakness (HP:0003473)3.24382352
26Upper limb muscle weakness (HP:0003484)3.22897435
27Abnormality of placental membranes (HP:0011409)3.15071667
28Amniotic constriction ring (HP:0009775)3.15071667
29Prolonged bleeding time (HP:0003010)3.12553603
30Paralysis (HP:0003470)3.09177571
31Increased connective tissue (HP:0009025)3.05924849
32Cholelithiasis (HP:0001081)2.96919885
33Acanthocytosis (HP:0001927)2.91734900
34Deformed tarsal bones (HP:0008119)2.86842841
35Absent phalangeal crease (HP:0006109)2.84910658
36Type 2 muscle fiber atrophy (HP:0003554)2.83847572
37Milia (HP:0001056)2.81784562
38Aortic aneurysm (HP:0004942)2.79759782
39Recurrent abscess formation (HP:0002722)2.78202760
40Calcaneovalgus deformity (HP:0001848)2.75748292
41Muscle fiber atrophy (HP:0100295)2.73560538
42Abnormal hemoglobin (HP:0011902)2.72291977
43Aortic dissection (HP:0002647)2.72153345
44Abnormal platelet function (HP:0011869)2.69852147
45Impaired platelet aggregation (HP:0003540)2.69852147
46Vertebral compression fractures (HP:0002953)2.69677235
47Hyporeflexia of lower limbs (HP:0002600)2.69593160
48Diaphragmatic weakness (HP:0009113)2.69119057
49Vascular tortuosity (HP:0004948)2.66913710
50Arterial tortuosity (HP:0005116)2.66782054
51Weak cry (HP:0001612)2.66778294
52Abnormal gallbladder morphology (HP:0012437)2.65412434
53Hyperparathyroidism (HP:0000843)2.64176272
54Distal lower limb muscle weakness (HP:0009053)2.61060643
55Thin ribs (HP:0000883)2.60617075
56Hyperthyroidism (HP:0000836)2.58011955
57Hypochromic anemia (HP:0001931)2.57496964
58Mesangial abnormality (HP:0001966)2.57278975
59Entropion (HP:0000621)2.57150606
60Abnormality of the Achilles tendon (HP:0005109)2.55255082
61Muscle fiber splitting (HP:0003555)2.52304756
62Purpura (HP:0000979)2.50868467
63Autoimmune thrombocytopenia (HP:0001973)2.46871398
64Abnormality of proline metabolism (HP:0010907)2.46627816
65Hydroxyprolinuria (HP:0003080)2.46627816
66Abnormality of reticulocytes (HP:0004312)2.41647014
67Mildly elevated creatine phosphokinase (HP:0008180)2.41111750
68Follicular hyperkeratosis (HP:0007502)2.40203018
69Tetraparesis (HP:0002273)2.39732820
70Fragile nails (HP:0001808)2.39063686
71Nail dystrophy (HP:0008404)2.37680296
72Pterygium (HP:0001059)2.36579875
73Achilles tendon contracture (HP:0001771)2.35614353
74Ankyloglossia (HP:0010296)2.35214088
75Hypertensive crisis (HP:0100735)2.34040272
76Abnormality of the calcaneus (HP:0008364)2.33211437
77Abnormality of the tricuspid valve (HP:0001702)2.32623559
78Abnormality of nail color (HP:0100643)2.32445720
79Distal lower limb amyotrophy (HP:0008944)2.32313516
80Cardiovascular calcification (HP:0011915)2.32282380
81Increased serum ferritin (HP:0003281)2.30393915
82Bladder diverticulum (HP:0000015)2.29728265
83Alopecia of scalp (HP:0002293)2.28546915
84Squamous cell carcinoma (HP:0002860)2.27320497
85Frequent falls (HP:0002359)2.27280071
86Urticaria (HP:0001025)2.26359907
87Easy fatigability (HP:0003388)2.25996302
88Nephritis (HP:0000123)2.25612626
89Pustule (HP:0200039)2.24725035
90Hip contracture (HP:0003273)2.22628087
91Focal segmental glomerulosclerosis (HP:0000097)2.21855062
92Difficulty climbing stairs (HP:0003551)2.21810067
93Mediastinal lymphadenopathy (HP:0100721)2.21597545
94Ulnar bowing (HP:0003031)2.20406175
95Upper limb amyotrophy (HP:0009129)2.20109702
96Distal upper limb amyotrophy (HP:0007149)2.20109702
97Slender build (HP:0001533)2.19951677
98Epistaxis (HP:0000421)2.19698369
99Spinal rigidity (HP:0003306)2.19361771
100Long clavicles (HP:0000890)2.18353552
101Abnormal finger flexion creases (HP:0006143)2.18013900
102Mitral stenosis (HP:0001718)2.17330533
103Vascular calcification (HP:0004934)2.16608408
104EMG: myopathic abnormalities (HP:0003458)2.13383986
105Abnormality of skeletal muscle fiber size (HP:0012084)2.13195285
106Microcytic anemia (HP:0001935)2.12553040
107Aplasia/Hypoplasia involving the musculature (HP:0001460)2.12266263
108Cervical subluxation (HP:0003308)2.11804057
109Recurrent gram-negative bacterial infections (HP:0005420)2.10739678
110Recurrent bacterial skin infections (HP:0005406)2.09678961
111Wormian bones (HP:0002645)2.08869472
112Premature rupture of membranes (HP:0001788)2.07361151
113Bulbar palsy (HP:0001283)2.07064464
114Hypoalbuminemia (HP:0003073)2.06975043
115Abnormal albumin level (HP:0012116)2.06975043
116Abnormality of iron homeostasis (HP:0011031)2.06548044
117Insomnia (HP:0100785)2.06425395
118Neonatal respiratory distress (HP:0002643)2.06011786
119Generalized muscle weakness (HP:0003324)2.04381364
120Thick nail (HP:0001805)2.02495085
121Mitral regurgitation (HP:0001653)2.02345476
122Ankle contracture (HP:0006466)2.01931622
123Increased variability in muscle fiber diameter (HP:0003557)2.00656356
124Metaphyseal cupping (HP:0003021)2.00650717
125Blue sclerae (HP:0000592)2.00612983
126Ileus (HP:0002595)2.00309756
127Gowers sign (HP:0003391)1.98051619
128Elbow flexion contracture (HP:0002987)1.96500343
129Cystic hygroma (HP:0000476)1.96017764
130Short middle phalanx of the 5th finger (HP:0004220)1.95918162
131Glomerulonephritis (HP:0000099)1.94886167
132Abnormality of oral frenula (HP:0000190)1.93406742
133Osteolytic defects of the hand bones (HP:0009699)1.92552288
134Osteolytic defects of the phalanges of the hand (HP:0009771)1.92552288
135Polycythemia (HP:0001901)1.90551788
136Natal tooth (HP:0000695)1.89380440
137Abnormality of macrophages (HP:0004311)1.89319455
138Abnormality of transition element cation homeostasis (HP:0011030)1.88199840
139Akinesia (HP:0002304)1.85975721
140Oligodontia (HP:0000677)1.83502888
141Cutaneous photosensitivity (HP:0000992)1.82948363
142Abnormal blistering of the skin (HP:0008066)1.82940945
143Nausea (HP:0002018)1.82839776
144Neonatal short-limb short stature (HP:0008921)1.82080082
145Deep venous thrombosis (HP:0002625)1.82023694
146Spondylolisthesis (HP:0003302)1.81694609
147Myocardial infarction (HP:0001658)1.81691097
148Lip pit (HP:0100267)1.80812299
149Plantar hyperkeratosis (HP:0007556)1.78040722
150Cholecystitis (HP:0001082)1.77498697
151Abnormal gallbladder physiology (HP:0012438)1.77498697
152Gingivitis (HP:0000230)1.77203376
153Short nail (HP:0001799)1.77122275
154Petechiae (HP:0000967)1.76957689
155Hypoplasia of dental enamel (HP:0006297)1.76901196
156Trismus (HP:0000211)1.76570588
157Lower limb amyotrophy (HP:0007210)1.76095361
158Atelectasis (HP:0100750)1.73169094
159Protrusio acetabuli (HP:0003179)1.72447191
160Osteomalacia (HP:0002749)1.72159773
161Bruising susceptibility (HP:0000978)1.72107290
162Venous abnormality (HP:0002624)1.71695022
163Interstitial pulmonary disease (HP:0006530)1.71470436
164Ridged nail (HP:0001807)1.71346469
165Hyperphosphatemia (HP:0002905)1.70825687
166Abnormality of the acetabulum (HP:0003170)1.70605116
167Generalized amyotrophy (HP:0003700)1.69869913
168Dilatation of the ascending aorta (HP:0005111)1.65954850
169Hypercortisolism (HP:0001578)1.65351531
170Poikiloderma (HP:0001029)1.64266310
171Reduced subcutaneous adipose tissue (HP:0003758)1.64068957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK3.13604404
2LATS22.75626463
3EPHA22.74425680
4EIF2AK12.57938970
5PIM12.41068867
6MAP3K142.26693971
7ARAF2.22995850
8TAOK22.19065806
9TRIB32.17127211
10ERN12.09212858
11BMX2.07209867
12PIM22.04983938
13STK102.03372174
14TRPM72.02655212
15PRPF4B2.01120267
16EIF2AK31.98406532
17MST1R1.95161439
18CDK121.92722352
19ZAK1.82854646
20TGFBR21.77045545
21TBK11.75463141
22SIK11.72880909
23MAP3K101.71871683
24NTRK11.67598088
25MAPKAPK31.67471331
26PIK3CG1.66918181
27EPHB11.66001017
28TLK11.63475523
29STK41.60459898
30PAK41.58124019
31PAK21.57289900
32IKBKB1.55975024
33MOS1.53293957
34MAP2K31.52986445
35CHUK1.49581518
36IKBKE1.48006266
37TTN1.47331934
38MST41.46813321
39CDK61.44695846
40MAP3K31.41624032
41DYRK31.40012280
42IRAK31.36750713
43DMPK1.33147684
44PDK21.25885528
45LMTK21.24262448
46MAP3K91.22418797
47RPS6KA41.22070878
48ILK1.21534776
49NME21.21144740
50ICK1.19912348
51LATS11.19030811
52MAP3K121.18714405
53MUSK1.18504529
54PKN21.18442763
55EEF2K1.15615308
56OBSCN1.11655650
57RPS6KB21.11501955
58STK31.09688173
59LRRK21.06678239
60FLT31.05170952
61MET1.04724953
62NEK91.00086076
63TESK10.99774680
64NEK10.97868456
65CDK80.97558470
66TAOK30.97395371
67AKT30.96435045
68MAP3K110.94057737
69PBK0.93860362
70MAP3K130.92441143
71MAP2K10.88571323
72MAPKAPK20.88416265
73JAK20.88183257
74BRAF0.87134867
75IRAK40.86502879
76PTK60.85876719
77DDR20.85371804
78MAP3K80.83444533
79RPS6KA50.83353670
80ABL20.77693774
81TEC0.77122236
82AKT20.76894561
83DYRK1B0.76676257
84PAK10.76667431
85EIF2AK20.75816890
86NME10.74794295
87RIPK40.71763835
88RIPK10.70233248
89JAK10.69852170
90JAK30.69849976
91MAP3K10.69116638
92PTK20.67572552
93PTK2B0.66338542
94MARK30.66318639
95MELK0.66098468
96HIPK20.65824254
97DAPK30.65212579
98CSK0.65112823
99SCYL20.64575817
100NEK20.64005727
101MAP3K60.63677807
102GRK60.63103285
103PRKD20.62971429
104ZAP700.62683954
105SMG10.61706127
106FRK0.61631706
107TYK20.61292877
108KSR20.60832618
109MAPK110.57251421
110AURKB0.56943516
111BRSK20.56597442
112CLK10.54508877
113RAF10.54404105
114PRKG20.54012413
115KSR10.53790769
116STK380.53685166
117CDK40.53611275
118ERBB40.53047115
119MAP3K50.52353442
120BLK0.52238729
121PDGFRA0.51175543
122RPS6KA20.50636105
123CDK90.49868284
124ROCK10.49087662
125GSK3A0.48838315
126SIK30.48137664
127EPHB20.46525862
128LIMK10.45425957
129KIT0.44795381
130MTOR0.44457226
131MAPK120.41743288
132RPS6KC10.41403386
133RPS6KL10.41403386
134PDPK10.41347694
135PDGFRB0.41299207
136AURKA0.40898477
137ABL10.39681361
138STK240.39671474
139RPS6KA60.39593176
140ROCK20.35472543
141STK160.34270018
142MAPK40.32496570
143ADRBK10.31893688
144CAMK2G0.31432668

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.31163420
2Systemic lupus erythematosus_Homo sapiens_hsa053222.65843065
3Prion diseases_Homo sapiens_hsa050202.54855324
4Leishmaniasis_Homo sapiens_hsa051402.41979824
5Legionellosis_Homo sapiens_hsa051342.24438713
6Malaria_Homo sapiens_hsa051442.01945519
7Small cell lung cancer_Homo sapiens_hsa052221.92010789
8Bladder cancer_Homo sapiens_hsa052191.89645069
9* Apoptosis_Homo sapiens_hsa042101.82456723
10ECM-receptor interaction_Homo sapiens_hsa045121.69586507
11Osteoclast differentiation_Homo sapiens_hsa043801.65913897
12Chronic myeloid leukemia_Homo sapiens_hsa052201.62757622
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.62504742
14TNF signaling pathway_Homo sapiens_hsa046681.57945484
15Hematopoietic cell lineage_Homo sapiens_hsa046401.57540414
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.57305636
17Viral carcinogenesis_Homo sapiens_hsa052031.52326805
18Amoebiasis_Homo sapiens_hsa051461.50201100
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47732527
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.46818985
21* p53 signaling pathway_Homo sapiens_hsa041151.45275759
22Toxoplasmosis_Homo sapiens_hsa051451.45008393
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42045399
24Ribosome_Homo sapiens_hsa030101.40646526
25Tuberculosis_Homo sapiens_hsa051521.39376533
26Salmonella infection_Homo sapiens_hsa051321.37540939
27Measles_Homo sapiens_hsa051621.34298461
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.32835306
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31733369
30Focal adhesion_Homo sapiens_hsa045101.27891896
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27247842
32Phagosome_Homo sapiens_hsa041451.26275748
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.26075571
34Pancreatic cancer_Homo sapiens_hsa052121.19414474
35Proteoglycans in cancer_Homo sapiens_hsa052051.19224700
36Galactose metabolism_Homo sapiens_hsa000521.18055324
37Pertussis_Homo sapiens_hsa051331.16611149
38MicroRNAs in cancer_Homo sapiens_hsa052061.16368728
39Hepatitis B_Homo sapiens_hsa051611.14915840
40African trypanosomiasis_Homo sapiens_hsa051431.14643248
41Complement and coagulation cascades_Homo sapiens_hsa046101.13187316
42Influenza A_Homo sapiens_hsa051641.10485492
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09432782
44Acute myeloid leukemia_Homo sapiens_hsa052211.09342100
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09145602
46Herpes simplex infection_Homo sapiens_hsa051681.08045389
47Lysosome_Homo sapiens_hsa041421.06039833
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05643352
49Staphylococcus aureus infection_Homo sapiens_hsa051501.04862069
50Adherens junction_Homo sapiens_hsa045201.04800005
51Rheumatoid arthritis_Homo sapiens_hsa053231.04570759
52Antigen processing and presentation_Homo sapiens_hsa046121.04538850
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.02746194
54Prostate cancer_Homo sapiens_hsa052151.01925625
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01153077
56Circadian rhythm_Homo sapiens_hsa047101.00570820
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95727406
58HIF-1 signaling pathway_Homo sapiens_hsa040660.95506033
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93256086
60ErbB signaling pathway_Homo sapiens_hsa040120.93004741
61Graft-versus-host disease_Homo sapiens_hsa053320.92971373
62Viral myocarditis_Homo sapiens_hsa054160.92616262
63Pentose phosphate pathway_Homo sapiens_hsa000300.92273895
64VEGF signaling pathway_Homo sapiens_hsa043700.91384265
65Endocytosis_Homo sapiens_hsa041440.90648410
66Shigellosis_Homo sapiens_hsa051310.89175063
67Hippo signaling pathway_Homo sapiens_hsa043900.88725686
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88033887
69Sulfur relay system_Homo sapiens_hsa041220.87350899
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85416450
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84627127
72* FoxO signaling pathway_Homo sapiens_hsa040680.84515112
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83940928
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83563357
75One carbon pool by folate_Homo sapiens_hsa006700.81443524
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81237210
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79479782
78Sulfur metabolism_Homo sapiens_hsa009200.79008558
79Epstein-Barr virus infection_Homo sapiens_hsa051690.78588487
80* Cell cycle_Homo sapiens_hsa041100.77529775
81Alcoholism_Homo sapiens_hsa050340.76908259
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76647839
83Selenocompound metabolism_Homo sapiens_hsa004500.76198408
84Hepatitis C_Homo sapiens_hsa051600.76071853
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.75709568
86mTOR signaling pathway_Homo sapiens_hsa041500.74015574
87Glutathione metabolism_Homo sapiens_hsa004800.73865928
88Insulin resistance_Homo sapiens_hsa049310.73501082
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72918284
90Glioma_Homo sapiens_hsa052140.72097303
91HTLV-I infection_Homo sapiens_hsa051660.71750536
92Other glycan degradation_Homo sapiens_hsa005110.70655777
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70104669
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70052023
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68912048
96Melanoma_Homo sapiens_hsa052180.68616813
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.67855153
98Renin-angiotensin system_Homo sapiens_hsa046140.66362019
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.65159428
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64025988
101Insulin signaling pathway_Homo sapiens_hsa049100.62000168
102Dilated cardiomyopathy_Homo sapiens_hsa054140.60626701
103TGF-beta signaling pathway_Homo sapiens_hsa043500.60439441
104Platelet activation_Homo sapiens_hsa046110.59244330
105Non-small cell lung cancer_Homo sapiens_hsa052230.58057730
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57861781
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57500255
108Fructose and mannose metabolism_Homo sapiens_hsa000510.57427293
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56053294
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51890156
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.51845437
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51647499
113Biosynthesis of amino acids_Homo sapiens_hsa012300.51640377
114Tight junction_Homo sapiens_hsa045300.50787134
115Protein digestion and absorption_Homo sapiens_hsa049740.49486874
116Starch and sucrose metabolism_Homo sapiens_hsa005000.49476390
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49466416
118Arginine and proline metabolism_Homo sapiens_hsa003300.48984332
119Notch signaling pathway_Homo sapiens_hsa043300.48702054
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.48657536
121Pathways in cancer_Homo sapiens_hsa052000.48566792
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48469939
123Renal cell carcinoma_Homo sapiens_hsa052110.48180173
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47701852
125Thyroid cancer_Homo sapiens_hsa052160.45123010
126Chemokine signaling pathway_Homo sapiens_hsa040620.44962464
127DNA replication_Homo sapiens_hsa030300.44778274
128Prolactin signaling pathway_Homo sapiens_hsa049170.44508643
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44241718
130Vibrio cholerae infection_Homo sapiens_hsa051100.42457080
131AMPK signaling pathway_Homo sapiens_hsa041520.42287710
132Endometrial cancer_Homo sapiens_hsa052130.42119911

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