GADD45B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)6.38153105
2response to muramyl dipeptide (GO:0032495)5.02101050
3regulation of interleukin-12 biosynthetic process (GO:0045075)4.54795593
4neutrophil activation involved in immune response (GO:0002283)4.25933855
5regulation of dendritic cell antigen processing and presentation (GO:0002604)4.24213300
6myeloid dendritic cell differentiation (GO:0043011)4.14072499
7positive regulation of heat generation (GO:0031652)4.08155086
8regulation of fever generation (GO:0031620)4.01816470
9antigen processing and presentation of endogenous antigen (GO:0019883)4.01790112
10response to peptidoglycan (GO:0032494)3.77553295
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.77286970
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.77286970
13myeloid dendritic cell activation (GO:0001773)3.73675191
14positive regulation of chemokine biosynthetic process (GO:0045080)3.71343329
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.66975268
16positive regulation by organism of defense response of other organism involved in symbiotic interact3.66975268
17modulation by symbiont of host immune response (GO:0052553)3.66975268
18positive regulation by symbiont of host defense response (GO:0052509)3.66975268
19modulation by symbiont of host defense response (GO:0052031)3.66975268
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.66975268
21positive regulation of interleukin-12 production (GO:0032735)3.65521065
22granulocyte activation (GO:0036230)3.64742084
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.60055273
24regulation of RIG-I signaling pathway (GO:0039535)3.53889871
25neutrophil activation (GO:0042119)3.53293913
26positive regulation of gamma-delta T cell activation (GO:0046645)3.52790994
27CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.52631664
28positive regulation of antigen processing and presentation (GO:0002579)3.48612749
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.47120084
30regulation of chronic inflammatory response (GO:0002676)3.44480405
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.43717303
32negative regulation of cell killing (GO:0031342)3.43717303
33lipopolysaccharide-mediated signaling pathway (GO:0031663)3.39405555
34positive regulation of interferon-alpha production (GO:0032727)3.37212432
35regulation of interferon-alpha production (GO:0032647)3.36255031
36interferon-gamma-mediated signaling pathway (GO:0060333)3.35258218
37positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.34839154
38regulation of interferon-beta biosynthetic process (GO:0045357)3.34630511
39natural killer cell mediated cytotoxicity (GO:0042267)3.33457379
40natural killer cell mediated immunity (GO:0002228)3.33457379
41regulation of T-helper 1 cell differentiation (GO:0045625)3.33241826
42positive regulation of cellular amide metabolic process (GO:0034250)3.31922366
43positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.27331223
44type I interferon signaling pathway (GO:0060337)3.27248130
45cellular response to type I interferon (GO:0071357)3.27248130
46response to type I interferon (GO:0034340)3.25930939
47positive regulation of natural killer cell differentiation (GO:0032825)3.25076096
48immunoglobulin mediated immune response (GO:0016064)3.23614246
49negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.22749932
50negative regulation of cytokine production involved in immune response (GO:0002719)3.21945875
51T-helper cell differentiation (GO:0042093)3.21888842
52CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.21888842
53regulation of interleukin-12 production (GO:0032655)3.21607995
54dendritic cell differentiation (GO:0097028)3.21561938
55detection of other organism (GO:0098543)3.20516251
56T-helper 1 type immune response (GO:0042088)3.20436584
57regulation of antigen processing and presentation (GO:0002577)3.18915854
58leukocyte aggregation (GO:0070486)3.16482482
59JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.15191645
60detection of bacterium (GO:0016045)3.14389650
61regulation of chemokine biosynthetic process (GO:0045073)3.12824222
62positive regulation of type 2 immune response (GO:0002830)3.10908174
63negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.08037230
64regulation of vitamin D biosynthetic process (GO:0060556)3.07951716
65positive regulation of humoral immune response (GO:0002922)3.04726332
66regulation of T-helper 2 cell differentiation (GO:0045628)3.04384395
67regulation of heat generation (GO:0031650)3.04049002
68negative regulation of interleukin-12 production (GO:0032695)2.98303137
69regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.97587964
70regulation of cytokine secretion involved in immune response (GO:0002739)2.96345507
71branching involved in labyrinthine layer morphogenesis (GO:0060670)2.95165638
72positive regulation of interleukin-2 production (GO:0032743)2.95054513
73germinal center formation (GO:0002467)2.94195374
74macrophage activation involved in immune response (GO:0002281)2.92846686
75positive regulation of interleukin-17 production (GO:0032740)2.92617829
76regulation of type I interferon-mediated signaling pathway (GO:0060338)2.89867360
77regulation of immunoglobulin secretion (GO:0051023)2.89542063
78regulation of gamma-delta T cell activation (GO:0046643)2.88226224
79T cell activation involved in immune response (GO:0002286)2.86238814
80regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.86036304
81positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.85347855
82mature B cell differentiation involved in immune response (GO:0002313)2.84776656
83regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.84380097
84monocyte chemotaxis (GO:0002548)2.83853865
85regulation of activation of Janus kinase activity (GO:0010533)2.83445086
86T cell differentiation involved in immune response (GO:0002292)2.82853873
87alpha-beta T cell differentiation involved in immune response (GO:0002293)2.82853873
88alpha-beta T cell activation involved in immune response (GO:0002287)2.82853873
89regulation of interleukin-8 biosynthetic process (GO:0045414)2.82216926
90regulation of necroptotic process (GO:0060544)2.82009652
91cytokine secretion (GO:0050663)2.81145941
92positive regulation of cytokine biosynthetic process (GO:0042108)2.80046178
93negative regulation of lipid storage (GO:0010888)2.79036757
94cellular response to interferon-gamma (GO:0071346)2.78054061
95positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.74717473
96regulation of podosome assembly (GO:0071801)2.74552235
97detection of external biotic stimulus (GO:0098581)2.73238197
98defense response to protozoan (GO:0042832)2.72611473
99regulation of type 2 immune response (GO:0002828)2.72256655
100positive regulation of T-helper cell differentiation (GO:0045624)2.71792272
101response to protozoan (GO:0001562)2.71597005
102detection of molecule of bacterial origin (GO:0032490)2.71252303
103regulation of vitamin metabolic process (GO:0030656)2.70142933
104regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.69907081
105positive regulation of interferon-beta production (GO:0032728)2.69692883
106growth hormone receptor signaling pathway (GO:0060396)2.68640490
107positive regulation of T-helper 1 type immune response (GO:0002827)2.67691194
108positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.67611585
109positive regulation of NF-kappaB import into nucleus (GO:0042346)2.67393036
110* activation of MAPKKK activity (GO:0000185)2.67188029
111tolerance induction (GO:0002507)2.66370085
112regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.66362276
113regulation of T-helper cell differentiation (GO:0045622)2.66321955
114positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.66005087
115cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.65501778
116regulation of response to interferon-gamma (GO:0060330)2.64267893
117nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.64159489
118leukocyte mediated cytotoxicity (GO:0001909)2.64111044
119macrophage activation (GO:0042116)2.63931203
120regulation of gamma-delta T cell differentiation (GO:0045586)2.63803444
121respiratory burst (GO:0045730)2.63731669
122regulation of alpha-beta T cell proliferation (GO:0046640)2.60987788
123T cell migration (GO:0072678)2.60690052
124mature B cell differentiation (GO:0002335)2.60447201
125regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.58569605
126negative regulation of innate immune response (GO:0045824)2.58422654
127interferon-gamma secretion (GO:0072643)2.57798638
128negative thymic T cell selection (GO:0045060)2.57662834
129negative regulation of erythrocyte differentiation (GO:0045647)2.57457959
130B cell mediated immunity (GO:0019724)2.56657165
131regulation of interleukin-2 biosynthetic process (GO:0045076)2.56278330
132negative regulation of production of molecular mediator of immune response (GO:0002701)2.55982929
133cellular response to arsenic-containing substance (GO:0071243)2.55552029
134response to interferon-gamma (GO:0034341)2.55067261
135regulation of B cell receptor signaling pathway (GO:0050855)2.54825511
136cellular response to lipopolysaccharide (GO:0071222)2.54511611
137negative regulation of viral genome replication (GO:0045071)2.52606410
138negative regulation of interleukin-6 production (GO:0032715)2.51653912
139positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.51341425
140positive regulation of B cell mediated immunity (GO:0002714)2.50160115
141positive regulation of immunoglobulin mediated immune response (GO:0002891)2.50160115

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.76579260
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.88737809
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.66384924
4* EGR1_19374776_ChIP-ChIP_THP-1_Human4.02175581
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.90524431
6* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.86862641
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.85053507
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.80049864
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.58275543
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.57286549
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.51714226
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.21500385
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.20567367
14IRF8_27001747_Chip-Seq_BMDM_Mouse3.19969953
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.11905349
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84056708
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.79139064
18* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.75044163
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.58331406
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.52366980
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35120599
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14215750
23RUNX_20019798_ChIP-Seq_JUKART_Human2.07701379
24MYB_26560356_Chip-Seq_TH2_Human2.01019612
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.96497243
26* MAF_26560356_Chip-Seq_TH1_Human1.95803252
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.90349154
28* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88657919
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76092039
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.75527281
31* VDR_24763502_ChIP-Seq_THP-1_Human1.72038139
32* MYB_26560356_Chip-Seq_TH1_Human1.68248117
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.66408792
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64220905
35TCF7_22412390_ChIP-Seq_EML_Mouse1.63136113
36SPI1_23547873_ChIP-Seq_NB4_Human1.62598692
37* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62207753
38MYC_22102868_ChIP-Seq_BL_Human1.61360474
39LXR_22292898_ChIP-Seq_THP-1_Human1.61316678
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57503328
41VDR_24787735_ChIP-Seq_THP-1_Human1.55541922
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53495329
43* ELK3_25401928_ChIP-Seq_HUVEC_Human1.52953208
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.51402041
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51337267
46* VDR_21846776_ChIP-Seq_THP-1_Human1.48095916
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45266780
48SCL_19346495_ChIP-Seq_HPC-7_Human1.44955112
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44765987
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44160712
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42620502
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.39838981
53* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38781429
54* PU_27001747_Chip-Seq_BMDM_Mouse1.36590199
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.36526671
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.35088013
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31089371
58* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30802074
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30682962
60* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30660819
61* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30660819
62* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29785546
63* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28060294
64* UTX_26944678_Chip-Seq_JUKART_Human1.26971500
65GATA3_27048872_Chip-Seq_THYMUS_Human1.26424749
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20879171
67PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20178274
68* CLOCK_20551151_ChIP-Seq_293T_Human1.19760241
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19379122
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18412634
71* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18003854
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17352929
73* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15833007
74SPI1_23127762_ChIP-Seq_K562_Human1.15378873
75* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15352024
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15264197
77* KDM2B_26808549_Chip-Seq_DND41_Human1.14694101
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14565153
79RACK7_27058665_Chip-Seq_MCF-7_Human1.14445062
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.13720818
81* MAF_26560356_Chip-Seq_TH2_Human1.11652285
82NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10658091
83PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09623622
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.06224966
85GATA1_22025678_ChIP-Seq_K562_Human1.05860837
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04024811
87GATA1_19941826_ChIP-Seq_K562_Human1.03249706
88* RXR_22158963_ChIP-Seq_LIVER_Mouse1.03129976
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03111434
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01316559
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01050640
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.00707491
93MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99430764
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.98965932
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98326700
96GATA3_26560356_Chip-Seq_TH2_Human0.97688479
97* UBF1/2_26484160_Chip-Seq_HMECs_Human0.97237570
98* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96290482
99* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94925161
100* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94151680
101GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93047898
102P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92585656
103CJUN_26792858_Chip-Seq_BT549_Human0.92542462
104EGR1_19032775_ChIP-ChIP_M12_Human0.91935322
105SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91814704
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91166645
107* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91025078
108* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90855194
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89178632
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85293496
111* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83575405
112ATF3_27146783_Chip-Seq_COLON_Human0.82160334
113* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82080174
114* NCOR1_26117541_ChIP-Seq_K562_Human0.81662699
115LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81129199
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80860163
117* SOX2_20726797_ChIP-Seq_SW620_Human0.80564497
118ZNF263_19887448_ChIP-Seq_K562_Human0.80553786

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.83254063
2MP0004510_myositis3.64005009
3MP0003436_decreased_susceptibility_to3.47642810
4MP0009785_altered_susceptibility_to3.35590495
5MP0000685_abnormal_immune_system3.30222366
6MP0003303_peritoneal_inflammation3.23351050
7MP0002148_abnormal_hypersensitivity_rea2.93372674
8MP0001790_abnormal_immune_system2.91267187
9MP0005387_immune_system_phenotype2.91267187
10* MP0005000_abnormal_immune_tolerance2.88187556
11MP0002254_reproductive_system_inflammat2.86352363
12MP0002138_abnormal_hepatobiliary_system2.75493461
13MP0003724_increased_susceptibility_to2.73252894
14MP0005671_abnormal_response_to2.60740266
15MP0002419_abnormal_innate_immunity2.55280695
16* MP0001800_abnormal_humoral_immune2.51922344
17* MP0002452_abnormal_antigen_presenting2.48929037
18MP0005025_abnormal_response_to2.42297526
19* MP0002723_abnormal_immune_serum2.39679926
20MP0004947_skin_inflammation2.29262463
21MP0001853_heart_inflammation2.26269942
22MP0002006_tumorigenesis2.14712677
23* MP0001819_abnormal_immune_cell2.14481192
24MP0002405_respiratory_system_inflammati2.12925325
25* MP0002420_abnormal_adaptive_immunity2.12815306
26MP0006082_CNS_inflammation2.09390259
27MP0002166_altered_tumor_susceptibility2.07085842
28MP0001533_abnormal_skeleton_physiology1.96360825
29MP0003448_altered_tumor_morphology1.90500859
30MP0002877_abnormal_melanocyte_morpholog1.89365438
31MP0010155_abnormal_intestine_physiology1.83187498
32MP0001348_abnormal_lacrimal_gland1.80376035
33MP0010352_gastrointestinal_tract_polyps1.79380158
34MP0005076_abnormal_cell_differentiation1.70758379
35* MP0001845_abnormal_inflammatory_respons1.68180594
36MP0003763_abnormal_thymus_physiology1.66522319
37MP0003191_abnormal_cellular_cholesterol1.66058187
38MP0003300_gastrointestinal_ulcer1.65822584
39MP0005310_abnormal_salivary_gland1.62557806
40* MP0000716_abnormal_immune_system1.61345628
41MP0002933_joint_inflammation1.61197438
42MP0000858_altered_metastatic_potential1.57894422
43MP0002139_abnormal_hepatobiliary_system1.57456215
44* MP0002398_abnormal_bone_marrow1.57071065
45MP0009333_abnormal_splenocyte_physiolog1.54566907
46MP0001873_stomach_inflammation1.53308238
47MP0003453_abnormal_keratinocyte_physiol1.51453685
48MP0002277_abnormal_respiratory_mucosa1.50008206
49MP0009764_decreased_sensitivity_to1.49679651
50MP0005451_abnormal_body_composition1.49186947
51MP0008004_abnormal_stomach_pH1.45805970
52MP0009278_abnormal_bone_marrow1.45691047
53MP0002998_abnormal_bone_remodeling1.42642555
54MP0002332_abnormal_exercise_endurance1.41259944
55MP0000343_altered_response_to1.32783473
56MP0005464_abnormal_platelet_physiology1.32580337
57MP0003091_abnormal_cell_migration1.30435322
58MP0005397_hematopoietic_system_phenotyp1.29083017
59MP0001545_abnormal_hematopoietic_system1.29083017
60* MP0002429_abnormal_blood_cell1.26811056
61MP0008469_abnormal_protein_level1.26153314
62MP0002009_preneoplasia1.23570269
63MP0005390_skeleton_phenotype1.22544880
64MP0003566_abnormal_cell_adhesion1.22089124
65* MP0002722_abnormal_immune_system1.20340517
66* MP0000689_abnormal_spleen_morphology1.19807667
67MP0003075_altered_response_to1.15745934
68MP0003656_abnormal_erythrocyte_physiolo1.15274926
69MP0003828_pulmonary_edema1.13186025
70MP0008438_abnormal_cutaneous_collagen1.12859314
71MP0001851_eye_inflammation1.11014685
72MP0005023_abnormal_wound_healing1.10889071
73MP0003172_abnormal_lysosome_physiology1.08245084
74MP0006054_spinal_hemorrhage1.07751437
75MP0005164_abnormal_response_to1.03074950
76MP0003950_abnormal_plasma_membrane1.02125854
77MP0001958_emphysema1.01241181
78MP0003705_abnormal_hypodermis_morpholog0.98473548
79MP0004808_abnormal_hematopoietic_stem0.98294642
80MP0000703_abnormal_thymus_morphology0.97294641
81MP0005165_increased_susceptibility_to0.95462288
82MP0002163_abnormal_gland_morphology0.94067044
83MP0000249_abnormal_blood_vessel0.93629462
84MP0003690_abnormal_glial_cell0.93197276
85MP0010307_abnormal_tumor_latency0.90269823
86MP0005167_abnormal_blood-brain_barrier0.88105736
87MP0001243_abnormal_dermal_layer0.82622461
88MP0009840_abnormal_foam_cell0.81140502
89MP0003795_abnormal_bone_structure0.79613475
90MP0008260_abnormal_autophagy0.79362143
91MP0000767_abnormal_smooth_muscle0.78264960
92MP0005166_decreased_susceptibility_to0.78075134
93MP0005275_abnormal_skin_tensile0.76848706
94MP0003279_aneurysm0.76440504
95MP0005058_abnormal_lysosome_morphology0.76269251
96MP0001501_abnormal_sleep_pattern0.75819121
97MP0001346_abnormal_lacrimal_gland0.75643968
98MP0005257_abnormal_intraocular_pressure0.74759325
99MP0004782_abnormal_surfactant_physiolog0.74046534
100MP0001881_abnormal_mammary_gland0.73135759
101MP0009763_increased_sensitivity_to0.70671422
102MP0003866_abnormal_defecation0.69070274
103MP0009765_abnormal_xenobiotic_induced0.66321838
104MP0005666_abnormal_adipose_tissue0.66217222
105MP0000569_abnormal_digit_pigmentation0.65961879
106MP0001216_abnormal_epidermal_layer0.65445468
107MP0004883_abnormal_blood_vessel0.64878667
108MP0002060_abnormal_skin_morphology0.64609589
109MP0003045_fibrosis0.64408233
110MP0001542_abnormal_bone_strength0.64350219
111MP0000465_gastrointestinal_hemorrhage0.64255662
112MP0005375_adipose_tissue_phenotype0.64154406
113MP0001879_abnormal_lymphatic_vessel0.64095149
114MP0000490_abnormal_crypts_of0.63642328
115MP0008874_decreased_physiological_sensi0.63114139
116MP0002295_abnormal_pulmonary_circulatio0.62565446
117MP0001663_abnormal_digestive_system0.60751873
118MP0002396_abnormal_hematopoietic_system0.60645504
119MP0000604_amyloidosis0.60542132
120MP0000609_abnormal_liver_physiology0.60316844

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.89008167
2Retrobulbar optic neuritis (HP:0100654)5.28249037
3Optic neuritis (HP:0100653)5.28249037
4Orchitis (HP:0100796)5.20574269
5Elevated erythrocyte sedimentation rate (HP:0003565)5.14284175
6Myositis (HP:0100614)4.98109646
7Recurrent abscess formation (HP:0002722)4.96636538
8Recurrent bacterial skin infections (HP:0005406)4.70139525
9Stomatitis (HP:0010280)4.53358350
10Mediastinal lymphadenopathy (HP:0100721)4.51159943
11Abnormality of liposaccharide metabolism (HP:0010968)4.32906365
12Abnormality of glycosphingolipid metabolism (HP:0004343)4.32906365
13Abnormality of glycolipid metabolism (HP:0010969)4.32906365
14Pulmonary infiltrates (HP:0002113)3.93855509
15Vasculitis (HP:0002633)3.86579296
16Recurrent fungal infections (HP:0002841)3.86101779
17Abnormality of macrophages (HP:0004311)3.79661375
18Recurrent gram-negative bacterial infections (HP:0005420)3.76855353
19Increased IgM level (HP:0003496)3.74788356
20Autoimmune thrombocytopenia (HP:0001973)3.69668116
21Gastrointestinal infarctions (HP:0005244)3.48605775
22Interstitial pulmonary disease (HP:0006530)3.46383680
23Arterial thrombosis (HP:0004420)3.35488749
24Keratoconjunctivitis sicca (HP:0001097)3.31349157
25Keratoconjunctivitis (HP:0001096)3.29328568
26Recurrent viral infections (HP:0004429)3.12993276
27Dysostosis multiplex (HP:0000943)3.12289928
28Peritonitis (HP:0002586)3.11664712
29Gingivitis (HP:0000230)3.11058162
30Recurrent skin infections (HP:0001581)3.06831930
31Vertebral compression fractures (HP:0002953)2.99733669
32Hematochezia (HP:0002573)2.89595109
33Hemoptysis (HP:0002105)2.88353375
34Leukocytosis (HP:0001974)2.86736512
35Loss of speech (HP:0002371)2.85164127
36Tetraparesis (HP:0002273)2.84881051
37Glomerulonephritis (HP:0000099)2.84515751
38Obstructive lung disease (HP:0006536)2.79064820
39Chronic obstructive pulmonary disease (HP:0006510)2.79064820
40Chronic otitis media (HP:0000389)2.78485932
41Myocardial infarction (HP:0001658)2.74704083
42Hypergammaglobulinemia (HP:0010702)2.73056926
43Persistence of primary teeth (HP:0006335)2.72122264
44Periodontitis (HP:0000704)2.66402389
45Recurrent cutaneous fungal infections (HP:0011370)2.64423477
46Chronic mucocutaneous candidiasis (HP:0002728)2.64423477
47Cellulitis (HP:0100658)2.64002449
48Increased cerebral lipofuscin (HP:0011813)2.61120881
49Complement deficiency (HP:0004431)2.60141975
50Parakeratosis (HP:0001036)2.59536178
51Basal ganglia calcification (HP:0002135)2.55897923
52Emphysema (HP:0002097)2.52448713
53Nasal polyposis (HP:0100582)2.52215357
54Osteolytic defects of the hand bones (HP:0009699)2.51899621
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.51899621
56Premature loss of primary teeth (HP:0006323)2.50882815
57Thrombocytosis (HP:0001894)2.49582973
58Pustule (HP:0200039)2.49126248
59Meningitis (HP:0001287)2.48512680
60Abnormality of complement system (HP:0005339)2.47987146
61Anhidrosis (HP:0000970)2.45883192
62Abnormality of the pericardium (HP:0001697)2.45722967
63Vacuolated lymphocytes (HP:0001922)2.45163400
64Increased IgE level (HP:0003212)2.44447692
65Abnormality of the nasal mucosa (HP:0000433)2.43964739
66Eosinophilia (HP:0001880)2.40668417
67Amyloidosis (HP:0011034)2.40117307
68Recurrent bronchitis (HP:0002837)2.38917215
69Abnormal delayed hypersensitivity skin test (HP:0002963)2.38910609
70Abnormality of polysaccharide metabolism (HP:0011012)2.35685382
71Abnormality of glycosaminoglycan metabolism (HP:0004371)2.35685382
72Abnormality of mucopolysaccharide metabolism (HP:0011020)2.35685382
73Segmental peripheral demyelination/remyelination (HP:0003481)2.35233913
74Nuclear cataract (HP:0100018)2.34443849
75Neurofibrillary tangles (HP:0002185)2.31409315
76Increased serum ferritin (HP:0003281)2.31331405
77Gingival bleeding (HP:0000225)2.25400410
78Thick nail (HP:0001805)2.24609787
79Osteomyelitis (HP:0002754)2.24598713
80Mucopolysacchariduria (HP:0008155)2.23741745
81Urinary glycosaminoglycan excretion (HP:0003541)2.23741745
82Abnormality of T cell number (HP:0011839)2.23237472
83Encephalitis (HP:0002383)2.21288460
84Arthralgia (HP:0002829)2.19096298
85Joint swelling (HP:0001386)2.18785614
86Anorexia (HP:0002039)2.16475127
87Recurrent pneumonia (HP:0006532)2.14656536
88Urticaria (HP:0001025)2.14462707
89Purpura (HP:0000979)2.11748136
90Abnormality of eosinophils (HP:0001879)2.11291408
91Recurrent lower respiratory tract infections (HP:0002783)2.11195369
92Chest pain (HP:0100749)2.10968459
93Prostate neoplasm (HP:0100787)2.09155956
94Porencephaly (HP:0002132)2.08651260
95Disinhibition (HP:0000734)2.08438904
96Increased density of long bones (HP:0006392)2.07498884
97Fatigue (HP:0012378)2.05090035
98Skin ulcer (HP:0200042)2.04497299
99Abnormality of T cell physiology (HP:0011840)2.03950166
100Increased neuronal autofluorescent lipopigment (HP:0002074)2.03921010
101Colitis (HP:0002583)2.03828495
102Malnutrition (HP:0004395)2.02888955
103Gangrene (HP:0100758)2.02864473
104Abnormality of cells of the lymphoid lineage (HP:0012140)2.02722955
105Gastrointestinal stroma tumor (HP:0100723)2.02677576
106Granulocytopenia (HP:0001913)2.02093087
107Nephritis (HP:0000123)2.01974219
108Axonal loss (HP:0003447)2.00141233
109Abnormality of T cells (HP:0002843)1.98378201
110Increased CSF protein (HP:0002922)1.97555495
111IgA deficiency (HP:0002720)1.96871402
112Agammaglobulinemia (HP:0004432)1.96670631
113Spontaneous hematomas (HP:0007420)1.95393230
114Abnormality of proline metabolism (HP:0010907)1.94822521
115Hydroxyprolinuria (HP:0003080)1.94822521
116Abnormality of the pleura (HP:0002103)1.92465809
117Asymmetric septal hypertrophy (HP:0001670)1.92341681
118Lymphopenia (HP:0001888)1.92116305
119IgG deficiency (HP:0004315)1.92044325
120Glomerulopathy (HP:0100820)1.90615687
121Inflammation of the large intestine (HP:0002037)1.90499194
122Autoimmune hemolytic anemia (HP:0001890)1.89112130
123Spondylolisthesis (HP:0003302)1.88514712
124Restrictive lung disease (HP:0002091)1.87794534
125Esophageal varix (HP:0002040)1.86965058
126Distal lower limb muscle weakness (HP:0009053)1.86411672
127Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84315851
128Slow saccadic eye movements (HP:0000514)1.83375834
129Systemic lupus erythematosus (HP:0002725)1.82761415
130Abnormality of the peritoneum (HP:0002585)1.81136230
131T lymphocytopenia (HP:0005403)1.80148935
132Pulmonary embolism (HP:0002204)1.80124364
133Polyneuropathy (HP:0001271)1.79313843
134Vertigo (HP:0002321)1.78818816
135Gastrointestinal inflammation (HP:0004386)1.77290420
136Pulmonary artery stenosis (HP:0004415)1.77070824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K146.07373141
2TBK13.89117845
3IKBKB3.62556178
4PRPF4B3.21447929
5IRAK33.13515864
6IKBKE3.12262779
7TYK22.87840037
8JAK32.82404545
9CHUK2.75149880
10PIM22.65258285
11TXK2.57789135
12MAP4K12.43979174
13IRAK42.25811163
14JAK12.06808389
15GRK71.93405572
16EPHB11.90886394
17MAP3K131.77877651
18EPHA31.68597387
19PIM11.65372797
20RIPK41.65024595
21DDR21.59972683
22BLK1.57624987
23ERN11.50910574
24RPS6KA41.50720238
25MAP3K31.47192491
26ZAP701.45493729
27KIT1.39553721
28CDC42BPA1.35369248
29BMX1.32500185
30MAP3K101.31925330
31STK101.24186866
32FGFR41.21879189
33SIK11.18434354
34CSK1.17101937
35TGFBR21.14206115
36TAOK31.13247380
37IRAK21.10110914
38FGFR31.08167294
39RIPK11.08143835
40MST41.06542858
41EIF2AK21.04331694
42TEC1.04147524
43MAPK71.03998136
44BTK1.03932463
45NLK0.97317341
46CDK120.95516179
47HCK0.95193220
48MAP2K30.94963433
49SIK20.93682540
50ITK0.93191914
51SYK0.93073806
52MAP3K110.93030181
53MAPK150.92481523
54JAK20.88973515
55MARK30.88665810
56LCK0.85969481
57NEK90.85556037
58BMPR20.83710251
59MAP2K20.82389149
60FES0.77025920
61PDK20.74423715
62MAPKAPK20.74373872
63MAPK40.73321694
64PTK60.73251138
65TESK20.72642408
66HIPK20.71841978
67LATS20.71068531
68SIK30.69848714
69PBK0.69706185
70MOS0.68836128
71RPS6KA50.68061509
72STK240.67755537
73LRRK20.63940389
74GRK60.63002243
75MAPK120.62171288
76CSF1R0.62006814
77ABL20.60794272
78TTN0.60222874
79NME20.59770715
80PDK10.59428190
81RPS6KA10.58682865
82IRAK10.58122926
83GSK3A0.57668549
84ABL10.56355660
85DAPK30.56234945
86PDPK10.55552435
87TNK20.55357333
88MAP3K10.53360909
89RPS6KL10.53179378
90RPS6KC10.53179378
91LYN0.52422343
92RAF10.51995331
93MAP3K50.50409364
94MAPK110.50105327
95SMG10.49382310
96TAOK10.48398600
97MATK0.46058641
98PRKD20.45699101
99TRPM70.45541937
100TSSK60.45404289
101PRKG20.44742863
102MELK0.43950695
103KDR0.43708620
104PRKCD0.42368580
105TRIB30.42001333
106STK30.41681974
107FLT30.39851374
108TESK10.39451344
109MARK20.39030271
110TAOK20.38438396
111RPS6KA60.38314890
112PDGFRB0.36024101
113EGFR0.35892428
114PKN10.35804588
115ALK0.35656877
116MYLK0.35649188
117PDGFRA0.34751335
118NUAK10.34604713
119PRKCQ0.33684874
120STK40.31697149
121INSR0.30569327
122EPHA20.30411262
123CDK90.30251329
124PAK40.30205035
125FGR0.29118843
126PRKAA20.27326881
127CDK60.26995750
128ARAF0.25178996

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.29010324
2* NF-kappa B signaling pathway_Homo sapiens_hsa040643.19398625
3Graft-versus-host disease_Homo sapiens_hsa053322.92971820
4Allograft rejection_Homo sapiens_hsa053302.91335116
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.73457852
6TNF signaling pathway_Homo sapiens_hsa046682.55272611
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.52741665
8Osteoclast differentiation_Homo sapiens_hsa043802.49824090
9Legionellosis_Homo sapiens_hsa051342.42328761
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.38134651
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.22323321
12Measles_Homo sapiens_hsa051622.18238079
13Malaria_Homo sapiens_hsa051442.16982751
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.14570440
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13100592
16Asthma_Homo sapiens_hsa053102.01967833
17Toxoplasmosis_Homo sapiens_hsa051451.96189188
18Type I diabetes mellitus_Homo sapiens_hsa049401.85712712
19Pertussis_Homo sapiens_hsa051331.80243393
20Rheumatoid arthritis_Homo sapiens_hsa053231.73829155
21Influenza A_Homo sapiens_hsa051641.72932212
22Antigen processing and presentation_Homo sapiens_hsa046121.68176318
23B cell receptor signaling pathway_Homo sapiens_hsa046621.67469681
24Herpes simplex infection_Homo sapiens_hsa051681.65923928
25* Apoptosis_Homo sapiens_hsa042101.62515660
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.61091196
27Tuberculosis_Homo sapiens_hsa051521.58825694
28African trypanosomiasis_Homo sapiens_hsa051431.57779272
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.54084005
30Autoimmune thyroid disease_Homo sapiens_hsa053201.53039294
31Primary immunodeficiency_Homo sapiens_hsa053401.45521653
32T cell receptor signaling pathway_Homo sapiens_hsa046601.44651160
33Shigellosis_Homo sapiens_hsa051311.41602178
34Salmonella infection_Homo sapiens_hsa051321.41205812
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40502658
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37061582
37Hematopoietic cell lineage_Homo sapiens_hsa046401.36138686
38Staphylococcus aureus infection_Homo sapiens_hsa051501.29938096
39Chemokine signaling pathway_Homo sapiens_hsa040621.26840528
40Hepatitis B_Homo sapiens_hsa051611.24938355
41Acute myeloid leukemia_Homo sapiens_hsa052211.14997046
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14799851
43Small cell lung cancer_Homo sapiens_hsa052221.13162753
44Viral myocarditis_Homo sapiens_hsa054161.08104927
45Chronic myeloid leukemia_Homo sapiens_hsa052201.05532889
46Hepatitis C_Homo sapiens_hsa051601.03407987
47Amoebiasis_Homo sapiens_hsa051461.01954554
48Epstein-Barr virus infection_Homo sapiens_hsa051691.01471467
49Systemic lupus erythematosus_Homo sapiens_hsa053221.00302928
50Prolactin signaling pathway_Homo sapiens_hsa049170.97883738
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.92509035
52Complement and coagulation cascades_Homo sapiens_hsa046100.91182951
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89207297
54HTLV-I infection_Homo sapiens_hsa051660.84507865
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81633119
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.80565745
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.78741945
58Phagosome_Homo sapiens_hsa041450.77609016
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77582002
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75654343
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75290549
62Viral carcinogenesis_Homo sapiens_hsa052030.73361212
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69146881
64Pancreatic cancer_Homo sapiens_hsa052120.69050631
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66167753
66MicroRNAs in cancer_Homo sapiens_hsa052060.63809361
67Lysosome_Homo sapiens_hsa041420.61893612
68Proteoglycans in cancer_Homo sapiens_hsa052050.55929893
69* MAPK signaling pathway_Homo sapiens_hsa040100.54976081
70* p53 signaling pathway_Homo sapiens_hsa041150.52868607
71Platelet activation_Homo sapiens_hsa046110.52751686
72HIF-1 signaling pathway_Homo sapiens_hsa040660.51987362
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50142252
74Prion diseases_Homo sapiens_hsa050200.48858769
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48790399
76Focal adhesion_Homo sapiens_hsa045100.48682333
77VEGF signaling pathway_Homo sapiens_hsa043700.48255925
78Insulin resistance_Homo sapiens_hsa049310.45460856
79Sphingolipid metabolism_Homo sapiens_hsa006000.43705164
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43302051
81ECM-receptor interaction_Homo sapiens_hsa045120.42802979
82Notch signaling pathway_Homo sapiens_hsa043300.39492853
83Prostate cancer_Homo sapiens_hsa052150.39425361
84Pathways in cancer_Homo sapiens_hsa052000.38582263
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37897649
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37203642
87TGF-beta signaling pathway_Homo sapiens_hsa043500.36740997
88GnRH signaling pathway_Homo sapiens_hsa049120.35660587
89* FoxO signaling pathway_Homo sapiens_hsa040680.35161103
90Bladder cancer_Homo sapiens_hsa052190.34184415
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.32263611
92Dorso-ventral axis formation_Homo sapiens_hsa043200.32169672
93Type II diabetes mellitus_Homo sapiens_hsa049300.30730835
94Adherens junction_Homo sapiens_hsa045200.30634467
95Other glycan degradation_Homo sapiens_hsa005110.29411944
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.28585188
97Endocytosis_Homo sapiens_hsa041440.25859763
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25460766
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.24842965
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24611641
101Colorectal cancer_Homo sapiens_hsa052100.23494750
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21677594
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21363572
104Renal cell carcinoma_Homo sapiens_hsa052110.21307491
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20467190
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19415964
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19259397
108PPAR signaling pathway_Homo sapiens_hsa033200.18340043
109Non-small cell lung cancer_Homo sapiens_hsa052230.17517645
110ErbB signaling pathway_Homo sapiens_hsa040120.16876357
111mTOR signaling pathway_Homo sapiens_hsa041500.15994093
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13029118
113Mineral absorption_Homo sapiens_hsa049780.12876576

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