GADD45G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.38197752
2Golgi transport vesicle coating (GO:0048200)5.05220932
3COPI coating of Golgi vesicle (GO:0048205)5.05220932
4protein retention in ER lumen (GO:0006621)5.00156885
5regulation of chronic inflammatory response (GO:0002676)4.66172462
6regulation of cytokine secretion involved in immune response (GO:0002739)4.62734367
7regulation of vitamin D biosynthetic process (GO:0060556)4.61726124
8positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr4.59967597
9regulation of mononuclear cell migration (GO:0071675)4.43165599
10virion attachment to host cell (GO:0019062)4.29808402
11adhesion of symbiont to host cell (GO:0044650)4.29808402
12nephron tubule morphogenesis (GO:0072078)4.26898315
13nephron epithelium morphogenesis (GO:0072088)4.26898315
14positive regulation of heat generation (GO:0031652)4.21892255
15signal peptide processing (GO:0006465)4.13035056
16negative regulation of interleukin-12 production (GO:0032695)4.11977608
17regulation of fever generation (GO:0031620)4.08305563
18branching involved in labyrinthine layer morphogenesis (GO:0060670)3.88978970
19regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.86976207
20monocyte chemotaxis (GO:0002548)3.79635211
21adhesion of symbiont to host (GO:0044406)3.78467378
22renal tubule morphogenesis (GO:0061333)3.76757982
23sarcoplasmic reticulum calcium ion transport (GO:0070296)3.76645424
24positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.76622386
25negative regulation of amino acid transport (GO:0051956)3.75760983
26regulation of membrane protein ectodomain proteolysis (GO:0051043)3.74623584
27regulation of T-helper 1 cell differentiation (GO:0045625)3.73353729
28positive regulation of chemokine biosynthetic process (GO:0045080)3.72109677
29positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.67408935
30pyrimidine-containing compound transmembrane transport (GO:0072531)3.58488377
31regulation of vitamin metabolic process (GO:0030656)3.55261100
32lipopolysaccharide-mediated signaling pathway (GO:0031663)3.55092099
33negative regulation of cytokine production involved in immune response (GO:0002719)3.48236936
34renal absorption (GO:0070293)3.43215193
35hydrogen peroxide biosynthetic process (GO:0050665)3.41333657
36myeloid dendritic cell differentiation (GO:0043011)3.39545661
37oligosaccharide catabolic process (GO:0009313)3.37751551
38glycosphingolipid catabolic process (GO:0046479)3.36888418
39NIK/NF-kappaB signaling (GO:0038061)3.34603433
40regulation of podosome assembly (GO:0071801)3.34459861
41creatine metabolic process (GO:0006600)3.31767109
42response to peptidoglycan (GO:0032494)3.30639026
43regulation of chemokine biosynthetic process (GO:0045073)3.29470318
44negative regulation of nitric oxide biosynthetic process (GO:0045019)3.25518338
45metanephric tubule development (GO:0072170)3.22944758
46metanephric nephron tubule development (GO:0072234)3.22944758
47regulation of immunoglobulin secretion (GO:0051023)3.20490036
48regulation of heat generation (GO:0031650)3.20072793
49eosinophil chemotaxis (GO:0048245)3.19600224
50facial nerve structural organization (GO:0021612)3.18449893
51T-helper 1 type immune response (GO:0042088)3.17515071
52negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.13820477
53response to corticosterone (GO:0051412)3.13430578
54regulation of cholesterol storage (GO:0010885)3.12517480
55response to protozoan (GO:0001562)3.10784511
56regulation of type B pancreatic cell apoptotic process (GO:2000674)3.09257631
57COPII vesicle coating (GO:0048208)3.07726625
58negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.06448118
59metanephric nephron epithelium development (GO:0072243)3.06009334
60* activation of MAPKKK activity (GO:0000185)3.02442846
61mitochondrial calcium ion transport (GO:0006851)3.01765774
62macrophage activation involved in immune response (GO:0002281)2.99709613
63glycolipid catabolic process (GO:0019377)2.98786188
64nephron tubule development (GO:0072080)2.98677764
65regulation of nitric oxide biosynthetic process (GO:0045428)2.98283272
66collecting duct development (GO:0072044)2.96816971
67regulation of heterotypic cell-cell adhesion (GO:0034114)2.96372661
68complement activation, alternative pathway (GO:0006957)2.94230333
69response to copper ion (GO:0046688)2.93417277
70reactive oxygen species biosynthetic process (GO:1903409)2.92252762
71collagen fibril organization (GO:0030199)2.90316394
72germinal center formation (GO:0002467)2.89190020
73wound healing, spreading of cells (GO:0044319)2.88724455
74positive regulation of nitric oxide biosynthetic process (GO:0045429)2.88355827
75negative regulation of myeloid cell apoptotic process (GO:0033033)2.87260148
76exocrine pancreas development (GO:0031017)2.87160259
77activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.86366840
78omega-hydroxylase P450 pathway (GO:0097267)2.86206176
79response to progesterone (GO:0032570)2.85895204
80tryptophan catabolic process (GO:0006569)2.85621700
81indole-containing compound catabolic process (GO:0042436)2.85621700
82indolalkylamine catabolic process (GO:0046218)2.85621700
83cellular response to lipopolysaccharide (GO:0071222)2.85564317
84cellular response to type I interferon (GO:0071357)2.85007330
85type I interferon signaling pathway (GO:0060337)2.85007330
86response to mineralocorticoid (GO:0051385)2.84493887
87sequestering of extracellular ligand from receptor (GO:0035581)2.84203719
88metanephric epithelium development (GO:0072207)2.83985064
89basement membrane organization (GO:0071711)2.83864190
90lung epithelium development (GO:0060428)2.83026971
91regulation of interferon-alpha production (GO:0032647)2.82195133
92amine catabolic process (GO:0009310)2.81909410
93cellular biogenic amine catabolic process (GO:0042402)2.81909410
94negative regulation of production of molecular mediator of immune response (GO:0002701)2.81360135
95defense response to protozoan (GO:0042832)2.81251632
96positive regulation of neurotransmitter secretion (GO:0001956)2.81066455
97cellular response to nicotine (GO:0071316)2.81020601
98response to type I interferon (GO:0034340)2.79246291
99cell adhesion mediated by integrin (GO:0033627)2.78545297
100eosinophil migration (GO:0072677)2.78430374
101positive regulation of triglyceride lipase activity (GO:0061365)2.76481659
102positive regulation of lipoprotein lipase activity (GO:0051006)2.76481659
103renal tubule development (GO:0061326)2.76121542
104endocrine pancreas development (GO:0031018)2.75753242
105chondrocyte proliferation (GO:0035988)2.75501497
106wound healing, spreading of epidermal cells (GO:0035313)2.74849424
107membrane lipid catabolic process (GO:0046466)2.74263919
108cellular response to molecule of bacterial origin (GO:0071219)2.73777544
109sequestering of metal ion (GO:0051238)2.73025790
110Notch signaling involved in heart development (GO:0061314)2.72839624
111regulation of circadian sleep/wake cycle (GO:0042749)2.71756711
112regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.71756711
113positive regulation of NF-kappaB import into nucleus (GO:0042346)2.71597260
114circadian sleep/wake cycle process (GO:0022410)2.71406087
115epoxygenase P450 pathway (GO:0019373)2.71065112
116regulation of macrophage chemotaxis (GO:0010758)2.70997870
117positive regulation of lipid storage (GO:0010884)2.70928833
118gland morphogenesis (GO:0022612)2.70314293
119sphingolipid catabolic process (GO:0030149)2.69821416
120atrioventricular valve morphogenesis (GO:0003181)2.69241201
121negative regulation of lipid storage (GO:0010888)2.68930192
122low-density lipoprotein particle clearance (GO:0034383)2.68573300
123ceramide catabolic process (GO:0046514)2.67683139
124response to muramyl dipeptide (GO:0032495)2.65905891
125ER overload response (GO:0006983)2.64944156
126positive regulation of nuclease activity (GO:0032075)2.64439391
127metanephric mesenchyme development (GO:0072075)2.63920146
128endothelial cell proliferation (GO:0001935)2.63446889
129positive regulation of lymphocyte apoptotic process (GO:0070230)2.62943967
130detection of molecule of bacterial origin (GO:0032490)2.61853800
131glycerophospholipid catabolic process (GO:0046475)2.60303665
132regulation of norepinephrine secretion (GO:0014061)2.60266835
133aromatic amino acid family catabolic process (GO:0009074)2.60262981
134regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.59712083
135negative regulation of sterol transport (GO:0032372)2.59174627
136negative regulation of cholesterol transport (GO:0032375)2.59174627
137myeloid dendritic cell activation (GO:0001773)2.58171609
138response to gravity (GO:0009629)2.58060493
139positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)2.57814200
140regulation of interleukin-8 biosynthetic process (GO:0045414)2.57752593
141retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.57495650
142endoplasmic reticulum unfolded protein response (GO:0030968)2.56938721
143negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.55586622
144response to fluid shear stress (GO:0034405)2.55504116
145response to inactivity (GO:0014854)2.55138150
146regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.54762597
147cellular response to unfolded protein (GO:0034620)2.54480122
148dendritic cell differentiation (GO:0097028)2.53791388
149vascular endothelial growth factor signaling pathway (GO:0038084)2.53377721
150plasma lipoprotein particle clearance (GO:0034381)2.53269130
151regulation of glutamate secretion (GO:0014048)2.53119772
152negative regulation of growth of symbiont in host (GO:0044130)2.52357333
153negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.52357333
154modulation of growth of symbiont involved in interaction with host (GO:0044144)2.52357333
155regulation of growth of symbiont in host (GO:0044126)2.52357333
156cellular response to thyroid hormone stimulus (GO:0097067)2.52227914
157negative regulation of fatty acid transport (GO:2000192)2.52086443
158protein maturation by protein folding (GO:0022417)2.50640648
159regulation of dendritic cell antigen processing and presentation (GO:0002604)2.48800165
160skin morphogenesis (GO:0043589)2.47608328
161nitric oxide mediated signal transduction (GO:0007263)2.46707157
162glandular epithelial cell differentiation (GO:0002067)2.46544539
163negative regulation of complement activation (GO:0045916)2.46491072
164negative regulation of glycoprotein biosynthetic process (GO:0010561)2.46346710
165nephron epithelium development (GO:0072009)2.45666823
166regulation of male gonad development (GO:2000018)2.45210271
167cellular response to ATP (GO:0071318)2.44052636
168positive regulation of collagen biosynthetic process (GO:0032967)2.43942082
169negative regulation of bone resorption (GO:0045779)2.43423833
170cornea development in camera-type eye (GO:0061303)2.43392382
171cellular response to topologically incorrect protein (GO:0035967)2.42167250
172positive regulation of cartilage development (GO:0061036)2.41711155
173response to follicle-stimulating hormone (GO:0032354)2.40401882
174keratan sulfate catabolic process (GO:0042340)2.39341940
175xenobiotic catabolic process (GO:0042178)2.38530480
176kidney mesenchyme development (GO:0072074)2.37640775
177mesonephric tubule development (GO:0072164)2.36831673
178lymphangiogenesis (GO:0001946)2.36756976
179mature B cell differentiation involved in immune response (GO:0002313)2.36297920
180regulation of nuclease activity (GO:0032069)2.35885356
181positive regulation of steroid hormone secretion (GO:2000833)2.35313951
182ER-nucleus signaling pathway (GO:0006984)2.34118524
183regulation of glucocorticoid metabolic process (GO:0031943)2.33835700
184regulation of plasminogen activation (GO:0010755)2.33741873
185protein heterotrimerization (GO:0070208)2.32923071
186positive regulation of extracellular matrix organization (GO:1903055)2.32181615
187cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.31945762
188peptide hormone processing (GO:0016486)2.31176970
189endothelial cell morphogenesis (GO:0001886)2.30987435
190muscle cell migration (GO:0014812)2.30983013
191positive regulation of blood vessel endothelial cell migration (GO:0043536)2.30948648
192extracellular fibril organization (GO:0043206)2.30619961
193mesonephric epithelium development (GO:0072163)2.30141849
194positive regulation of collagen metabolic process (GO:0010714)2.30139279
195positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.29721766
196cellular response to vitamin D (GO:0071305)2.29254346
197cellular response to vitamin (GO:0071295)2.28677043
198regulation of integrin-mediated signaling pathway (GO:2001044)2.26666682
199retina vasculature morphogenesis in camera-type eye (GO:0061299)2.26348975
200negative regulation of glycoprotein metabolic process (GO:1903019)2.26022024

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.45729966
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.74222666
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.40180965
4CLOCK_20551151_ChIP-Seq_293T_Human3.85799195
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.05308603
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.92836966
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.88371435
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.75222399
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.72341768
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.68756841
11TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.60291639
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.34928402
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.31582140
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.30541019
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.15541934
16CJUN_26792858_Chip-Seq_BT549_Human2.09703563
17ERG_21242973_ChIP-ChIP_JURKAT_Human2.07427608
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04128770
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.03392702
20SRY_22984422_ChIP-ChIP_TESTIS_Rat2.02585757
21* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99368996
22* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.99132638
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96508534
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.96220444
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.95128498
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.93318486
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.86469776
28RXR_22158963_ChIP-Seq_LIVER_Mouse1.80766863
29DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.77075072
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.75870102
31* TP53_20018659_ChIP-ChIP_R1E_Mouse1.75376318
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.74717564
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.72964102
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72436825
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.71294292
36SOX2_20726797_ChIP-Seq_SW620_Human1.71166213
37* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69399697
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.63941727
39VDR_21846776_ChIP-Seq_THP-1_Human1.62858048
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.62601534
41* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.59657076
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54310010
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52561164
44* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51804570
45VDR_24787735_ChIP-Seq_THP-1_Human1.50480939
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50070487
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49061797
48* LXR_22158963_ChIP-Seq_LIVER_Mouse1.46871128
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44345781
50* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43491480
51* EED_16625203_ChIP-ChIP_MESCs_Mouse1.43367752
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.43116792
53* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41786318
54KDM2B_26808549_Chip-Seq_K562_Human1.40889350
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.40744825
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.40744825
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40281754
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38143831
59ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37420481
60* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35347076
61* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.33189436
62EZH2_22144423_ChIP-Seq_EOC_Human1.33047867
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32850374
64KDM2B_26808549_Chip-Seq_DND41_Human1.29731838
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28919096
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28448018
67GATA1_22025678_ChIP-Seq_K562_Human1.26431624
68* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25682437
69* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24474923
70VDR_24763502_ChIP-Seq_THP-1_Human1.23660456
71STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23366900
72IRF8_22096565_ChIP-ChIP_GC-B_Human1.22175561
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22062701
74* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20673438
75* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20457224
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19316604
77KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19019639
78KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19019639
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19019639
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18947401
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18582555
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.18099504
83* EZH2_27294783_Chip-Seq_ESCs_Mouse1.17367318
84* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17205955
85TBX20_22328084_ChIP-Seq_HEART_Mouse1.17146558
86TBX20_22080862_ChIP-Seq_HEART_Mouse1.17146558
87* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17111926
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16541487
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16244980
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16193021
91* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16162407
92BRD4_25478319_ChIP-Seq_HGPS_Human1.15191775
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14834937
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14648747
95SA1_27219007_Chip-Seq_Bcells_Human1.14472210
96* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13782094
97BCL6_27268052_Chip-Seq_Bcells_Human1.13576531
98STAT1_20625510_ChIP-Seq_HELA_Human1.13443182
99* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12628778
100* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12628778
101* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12283476
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11619061
103FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11203055
104EP300_21415370_ChIP-Seq_HL-1_Mouse1.11037266
105* RACK7_27058665_Chip-Seq_MCF-7_Human1.10095168
106BCOR_27268052_Chip-Seq_Bcells_Human1.08459704
107* UBF1/2_26484160_Chip-Seq_HMECs_Human1.08285077
108SMC4_20622854_ChIP-Seq_HELA_Human1.08194642
109* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08184497
110MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08038354
111* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06644423
112SA1_27219007_Chip-Seq_ERYTHROID_Human1.06616883
113LXR_22292898_ChIP-Seq_THP-1_Human1.06583181
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05943448
115CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05608150
116ELF1_20517297_ChIP-Seq_JURKAT_Human1.04507563
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03123710
118* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02318835
119* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01517959
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01486119
121CTCF_27219007_Chip-Seq_Bcells_Human1.01204917
122* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01116692
123PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00852608
124* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00584698
125CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99922462
126* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99470185
127* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99206443
128MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98901133
129KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98708407
130P68_20966046_ChIP-Seq_HELA_Human0.98369336
131EGR1_19032775_ChIP-ChIP_M12_Human0.97541814
132* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97374301
133UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97344101
134STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97235092
135* ATF3_27146783_Chip-Seq_COLON_Human0.96547070
136FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96538218
137ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94789389
138TCF7_22412390_ChIP-Seq_EML_Mouse0.94416054
139TP53_18474530_ChIP-ChIP_U2OS_Human0.93957699
140NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93547663
141FOXO3_23340844_ChIP-Seq_DLD1_Human0.93315883
142* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92682604
143* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92660793
144* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92360807
145GATA1_19941827_ChIP-Seq_MEL_Mouse0.91966488
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91836077
147* CTCF_26484167_Chip-Seq_Bcells_Mouse0.91521817
148CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90660193
149* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90452339
150* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90452339
151* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90397192
152SPI1_23127762_ChIP-Seq_K562_Human0.90327163
153TET1_21451524_ChIP-Seq_MESCs_Mouse0.89906759
154ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89521280
155NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89336234
156STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.89323699
157VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87903081
158TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87782406
159SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87622157
160* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87412896
161RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87217722
162BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86991465
163* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85904731
164NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83011910
165* RING1B_27294783_Chip-Seq_ESCs_Mouse0.82568640
166IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82349716
167TP53_23651856_ChIP-Seq_MEFs_Mouse0.81565834
168SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81241341
169PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80815875

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.51226471
2MP0003279_aneurysm4.49716561
3MP0005058_abnormal_lysosome_morphology3.74964681
4MP0009840_abnormal_foam_cell3.35344094
5MP0005503_abnormal_tendon_morphology3.27058716
6MP0006082_CNS_inflammation3.13890101
7* MP0002148_abnormal_hypersensitivity_rea2.92666583
8MP0005167_abnormal_blood-brain_barrier2.76384806
9MP0009785_altered_susceptibility_to2.67094023
10MP0004272_abnormal_basement_membrane2.63305911
11MP0003724_increased_susceptibility_to2.57220281
12MP0002653_abnormal_ependyma_morphology2.55262135
13MP0002928_abnormal_bile_duct2.51552588
14MP0005275_abnormal_skin_tensile2.49420341
15MP0003436_decreased_susceptibility_to2.47983571
16MP0001542_abnormal_bone_strength2.44679425
17MP0010368_abnormal_lymphatic_system2.43701723
18MP0002877_abnormal_melanocyte_morpholog2.41365724
19MP0003075_altered_response_to2.35058559
20MP0005220_abnormal_exocrine_pancreas2.34740373
21MP0000013_abnormal_adipose_tissue2.26096773
22MP0001958_emphysema2.22743266
23MP0009384_cardiac_valve_regurgitation2.12013192
24MP0000604_amyloidosis2.09861341
25MP0005257_abnormal_intraocular_pressure2.08750859
26MP0005451_abnormal_body_composition2.04771516
27MP0002837_dystrophic_cardiac_calcinosis2.04189360
28MP0001879_abnormal_lymphatic_vessel1.97939364
29MP0003045_fibrosis1.96258644
30MP0001790_abnormal_immune_system1.93272287
31MP0005387_immune_system_phenotype1.93272287
32MP0002332_abnormal_exercise_endurance1.92355769
33MP0010030_abnormal_orbit_morphology1.92133543
34MP0005508_abnormal_skeleton_morphology1.90380985
35MP0005000_abnormal_immune_tolerance1.88415356
36MP0005671_abnormal_response_to1.86063214
37MP0003806_abnormal_nucleotide_metabolis1.85643469
38MP0000749_muscle_degeneration1.84421703
39MP0005025_abnormal_response_to1.80267678
40MP0005084_abnormal_gallbladder_morpholo1.78464770
41MP0008004_abnormal_stomach_pH1.73862398
42MP0003690_abnormal_glial_cell1.70598979
43MP0010386_abnormal_urinary_bladder1.69119172
44MP0002419_abnormal_innate_immunity1.69079669
45MP0003252_abnormal_bile_duct1.67375090
46MP0002896_abnormal_bone_mineralization1.63264747
47MP0006054_spinal_hemorrhage1.60964297
48MP0003646_muscle_fatigue1.58168057
49MP0000678_abnormal_parathyroid_gland1.56780636
50MP0005670_abnormal_white_adipose1.56066701
51MP0003453_abnormal_keratinocyte_physiol1.55500837
52MP0003566_abnormal_cell_adhesion1.53179457
53MP0001853_heart_inflammation1.49729400
54MP0001944_abnormal_pancreas_morphology1.48464236
55MP0005390_skeleton_phenotype1.47623147
56MP0003172_abnormal_lysosome_physiology1.45115329
57MP0003329_amyloid_beta_deposits1.44522625
58MP0000003_abnormal_adipose_tissue1.44021338
59MP0002295_abnormal_pulmonary_circulatio1.42173483
60MP0008469_abnormal_protein_level1.41346581
61MP0002168_other_aberrant_phenotype1.40481622
62MP0005023_abnormal_wound_healing1.39868968
63MP0003705_abnormal_hypodermis_morpholog1.38168454
64MP0002138_abnormal_hepatobiliary_system1.38058112
65MP0001533_abnormal_skeleton_physiology1.37452961
66MP0000767_abnormal_smooth_muscle1.35712255
67MP0005646_abnormal_pituitary_gland1.35053595
68MP0002933_joint_inflammation1.34598066
69MP0000343_altered_response_to1.32840303
70MP0005365_abnormal_bile_salt1.32805912
71* MP0002723_abnormal_immune_serum1.31842954
72MP0003191_abnormal_cellular_cholesterol1.31641266
73MP0001845_abnormal_inflammatory_respons1.29960047
74MP0010155_abnormal_intestine_physiology1.29152536
75MP0001270_distended_abdomen1.28647437
76MP0004947_skin_inflammation1.28363080
77MP0001835_abnormal_antigen_presentation1.27395435
78MP0003941_abnormal_skin_development1.26578164
79MP0003385_abnormal_body_wall1.25624673
80MP0005166_decreased_susceptibility_to1.24890228
81MP0000163_abnormal_cartilage_morphology1.23819739
82MP0002452_abnormal_antigen_presenting1.23638882
83MP0003879_abnormal_hair_cell1.20998980
84MP0005164_abnormal_response_to1.20521745
85MP0009780_abnormal_chondrocyte_physiolo1.20326918
86MP0001800_abnormal_humoral_immune1.19912160
87MP0001501_abnormal_sleep_pattern1.17542861
88MP0003283_abnormal_digestive_organ1.17022202
89MP0005083_abnormal_biliary_tract1.15365402
90MP0002249_abnormal_larynx_morphology1.15324487
91MP0004043_abnormal_pH_regulation1.14349567
92MP0008961_abnormal_basal_metabolism1.13629938
93MP0003195_calcinosis1.13363408
94MP0003300_gastrointestinal_ulcer1.12842557
95MP0002254_reproductive_system_inflammat1.09722054
96MP0002998_abnormal_bone_remodeling1.07978562
97MP0008875_abnormal_xenobiotic_pharmacok1.07798123
98MP0000049_abnormal_middle_ear1.07467772
99MP0002060_abnormal_skin_morphology1.07180138
100MP0009643_abnormal_urine_homeostasis1.06607358
101MP0002693_abnormal_pancreas_physiology1.06520793
102MP0009250_abnormal_appendicular_skeleto1.06379920
103MP0000750_abnormal_muscle_regeneration1.05768106
104MP0003942_abnormal_urinary_system1.05099165
105MP0005310_abnormal_salivary_gland1.04834207
106MP0003795_abnormal_bone_structure1.04443148
107MP0004858_abnormal_nervous_system1.01198306
108MP0005379_endocrine/exocrine_gland_phen1.00825003
109MP0005666_abnormal_adipose_tissue1.00686565
110MP0004883_abnormal_blood_vessel1.00258559
111MP0005165_increased_susceptibility_to0.99325072
112MP0001545_abnormal_hematopoietic_system0.99185086
113MP0005397_hematopoietic_system_phenotyp0.99185086
114MP0003943_abnormal_hepatobiliary_system0.98956237
115MP0003656_abnormal_erythrocyte_physiolo0.98251836
116MP0009764_decreased_sensitivity_to0.98217210
117MP0000920_abnormal_myelination0.97963909
118MP0003828_pulmonary_edema0.97305971
119MP0005595_abnormal_vascular_smooth0.96954406
120MP0003634_abnormal_glial_cell0.96895969
121MP0005535_abnormal_body_temperature0.96716006
122MP0001243_abnormal_dermal_layer0.96014265
123MP0000534_abnormal_ureter_morphology0.94304858
124MP0002139_abnormal_hepatobiliary_system0.94145996
125MP0009278_abnormal_bone_marrow0.93332252
126MP0009333_abnormal_splenocyte_physiolog0.92606811
127MP0003303_peritoneal_inflammation0.90416265
128MP0002163_abnormal_gland_morphology0.90247245
129MP0001756_abnormal_urination0.90190884
130MP0005647_abnormal_sex_gland0.87694715
131MP0001502_abnormal_circadian_rhythm0.86572629
132MP0005623_abnormal_meninges_morphology0.86470479
133MP0001663_abnormal_digestive_system0.86125026
134MP0002932_abnormal_joint_morphology0.85882557
135* MP0001819_abnormal_immune_cell0.85299883
136* MP0002420_abnormal_adaptive_immunity0.85174312
137MP0002405_respiratory_system_inflammati0.83889801
138MP0002113_abnormal_skeleton_development0.82078910
139MP0000685_abnormal_immune_system0.81483955
140MP0009765_abnormal_xenobiotic_induced0.80687092
141MP0009763_increased_sensitivity_to0.80574258
142MP0000249_abnormal_blood_vessel0.80440426
143MP0002108_abnormal_muscle_morphology0.80353070
144MP0004510_myositis0.79170958
145MP0000538_abnormal_urinary_bladder0.79144017
146MP0002115_abnormal_skeleton_extremities0.78062212
147MP0000858_altered_metastatic_potential0.76375395
148MP0003633_abnormal_nervous_system0.74888540
149MP0008874_decreased_physiological_sensi0.73735662
150MP0003091_abnormal_cell_migration0.72984778
151MP0002128_abnormal_blood_circulation0.72391233
152MP0003137_abnormal_impulse_conducting0.72089890
153MP0005266_abnormal_metabolism0.71451726
154MP0000230_abnormal_systemic_arterial0.71225086
155MP0001764_abnormal_homeostasis0.70874005
156MP0002277_abnormal_respiratory_mucosa0.70632907
157MP0005332_abnormal_amino_acid0.69342946
158MP0002909_abnormal_adrenal_gland0.68493464
159MP0003448_altered_tumor_morphology0.67824737
160MP0005584_abnormal_enzyme/coenzyme_acti0.67673988
161MP0000609_abnormal_liver_physiology0.67500074
162MP0002118_abnormal_lipid_homeostasis0.67386342
163MP0001765_abnormal_ion_homeostasis0.67366574
164MP0000733_abnormal_muscle_development0.67198016
165MP0002269_muscular_atrophy0.66845620
166MP0000613_abnormal_salivary_gland0.66014019
167MP0003183_abnormal_peptide_metabolism0.65880289
168MP0005319_abnormal_enzyme/_coenzyme0.65775763
169MP0002234_abnormal_pharynx_morphology0.64890014
170MP0002078_abnormal_glucose_homeostasis0.64425153
171MP0005375_adipose_tissue_phenotype0.63204478
172MP0005334_abnormal_fat_pad0.62956929
173MP0001727_abnormal_embryo_implantation0.62067886
174MP0003186_abnormal_redox_activity0.60661155
175MP0003123_paternal_imprinting0.53957997

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)7.09536240
2Abnormality of glycosphingolipid metabolism (HP:0004343)7.09536240
3Abnormality of glycolipid metabolism (HP:0010969)7.09536240
4Systemic lupus erythematosus (HP:0002725)6.52038477
5Premature rupture of membranes (HP:0001788)5.54312016
6Cerebral aneurysm (HP:0004944)5.42233755
7Complement deficiency (HP:0004431)4.90062719
8Disinhibition (HP:0000734)4.75723003
9Glomerulonephritis (HP:0000099)4.60041831
10Vacuolated lymphocytes (HP:0001922)4.59689247
11Neurofibrillary tangles (HP:0002185)4.47022505
12Increased cerebral lipofuscin (HP:0011813)4.37367965
13Protrusio acetabuli (HP:0003179)4.36233767
14Loss of speech (HP:0002371)4.23110171
15Nuclear cataract (HP:0100018)4.16308817
16Axonal loss (HP:0003447)4.05152531
17Mutism (HP:0002300)3.99296456
18Retrobulbar optic neuritis (HP:0100654)3.81787518
19Optic neuritis (HP:0100653)3.81787518
20Orchitis (HP:0100796)3.66248904
21Abnormality of macrophages (HP:0004311)3.58210657
22Abnormality of complement system (HP:0005339)3.56199684
23Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.50813482
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.46722490
25Vertebral compression fractures (HP:0002953)3.45871479
26Abnormality of dentin (HP:0010299)3.37831313
27Aortic aneurysm (HP:0004942)3.32372159
28Atrophic scars (HP:0001075)3.29453662
29Cerebral inclusion bodies (HP:0100314)3.21380377
30Hypoglycemic coma (HP:0001325)3.14525379
31Increased connective tissue (HP:0009025)3.13955268
32Fragile skin (HP:0001030)3.08967045
33Distal lower limb muscle weakness (HP:0009053)3.08448545
34Stomatitis (HP:0010280)3.07694107
35Abnormal pancreas size (HP:0012094)3.05571187
36Autoimmune thrombocytopenia (HP:0001973)3.04225239
37Short nail (HP:0001799)3.02161545
38Hypoglycemic seizures (HP:0002173)3.01186368
39Myositis (HP:0100614)3.00969403
40Aortic dissection (HP:0002647)2.97938711
41Increased serum ferritin (HP:0003281)2.96070219
42Abnormality of monocarboxylic acid metabolism (HP:0010996)2.92227060
43Recurrent gram-negative bacterial infections (HP:0005420)2.90692699
44Spinal rigidity (HP:0003306)2.87569935
45Hyperactive renin-angiotensin system (HP:0000841)2.86823720
46Purpura (HP:0000979)2.85217399
47Soft skin (HP:0000977)2.84374530
48Mediastinal lymphadenopathy (HP:0100721)2.76281447
49Neoplasm of the adrenal cortex (HP:0100641)2.75195995
50Inappropriate behavior (HP:0000719)2.72620411
51Prolonged neonatal jaundice (HP:0006579)2.71926886
52Diminished motivation (HP:0000745)2.68517962
53Progressive neurologic deterioration (HP:0002344)2.62071909
54Apathy (HP:0000741)2.61544859
55Asymmetric septal hypertrophy (HP:0001670)2.59897780
56Aneurysm (HP:0002617)2.59304529
57Stomach cancer (HP:0012126)2.57206051
58Symptomatic seizures (HP:0011145)2.53655987
59Mesangial abnormality (HP:0001966)2.50101991
60Blue sclerae (HP:0000592)2.49111029
61Recurrent bacterial skin infections (HP:0005406)2.48938539
62Peritonitis (HP:0002586)2.47881079
63Biconcave vertebral bodies (HP:0004586)2.46590295
64Retinal atrophy (HP:0001105)2.46301515
65Type 1 muscle fiber predominance (HP:0003803)2.43577051
66Anomalous pulmonary venous return (HP:0010772)2.43457299
67Bladder diverticulum (HP:0000015)2.43053068
68Xanthomatosis (HP:0000991)2.42005390
69Unilateral renal agenesis (HP:0000122)2.41967392
70Dilatation of the ascending aorta (HP:0005111)2.40750777
71Cystic liver disease (HP:0006706)2.39819553
72Bowel diverticulosis (HP:0005222)2.39587613
73Amyloidosis (HP:0011034)2.39271719
74Hyperinsulinemic hypoglycemia (HP:0000825)2.39096116
75Renal cortical cysts (HP:0000803)2.35211705
76Abnormality of iron homeostasis (HP:0011031)2.33862637
77Right ventricular cardiomyopathy (HP:0011663)2.33839190
78Keratoconjunctivitis sicca (HP:0001097)2.33563960
79Dementia (HP:0000726)2.33053725
80Neuronal loss in central nervous system (HP:0002529)2.32326246
81Wormian bones (HP:0002645)2.32219408
82Gangrene (HP:0100758)2.31617542
83Nephritis (HP:0000123)2.31191399
84Nausea (HP:0002018)2.30844630
85Recurrent abscess formation (HP:0002722)2.28548333
86Broad metatarsal (HP:0001783)2.27954082
87Agnosia (HP:0010524)2.26966154
88Follicular hyperkeratosis (HP:0007502)2.26014690
89Shallow orbits (HP:0000586)2.25749180
90Personality changes (HP:0000751)2.22340490
91Eczematoid dermatitis (HP:0000976)2.22219733
92Neoplasm of the adrenal gland (HP:0100631)2.22035153
93Pulmonary infiltrates (HP:0002113)2.21339932
94Abnormality of proline metabolism (HP:0010907)2.17822473
95Hydroxyprolinuria (HP:0003080)2.17822473
96Bulbar palsy (HP:0001283)2.15127018
97Abnormality of the pulmonary veins (HP:0011718)2.14510672
98Upper motor neuron abnormality (HP:0002127)2.14002247
99Intrahepatic cholestasis (HP:0001406)2.13938622
100Generalized aminoaciduria (HP:0002909)2.13870914
101Cervical subluxation (HP:0003308)2.13442621
102Difficulty climbing stairs (HP:0003551)2.12390601
103Keratoconjunctivitis (HP:0001096)2.12290995
104Spondylolisthesis (HP:0003302)2.11102228
105Late onset (HP:0003584)2.09445825
106Mitral stenosis (HP:0001718)2.09068522
107Exocrine pancreatic insufficiency (HP:0001738)2.06968425
108Mildly elevated creatine phosphokinase (HP:0008180)2.06030285
109Parakeratosis (HP:0001036)2.04759485
110Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02452354
111Metaphyseal irregularity (HP:0003025)2.02225054
112Muscle fiber splitting (HP:0003555)2.01573329
113Gout (HP:0001997)2.01469122
114Peripheral demyelination (HP:0011096)2.00742662
115Hyperglycemia (HP:0003074)2.00139251
116Deep venous thrombosis (HP:0002625)1.99227249
117Insulin resistance (HP:0000855)1.99089214
118Increased IgM level (HP:0003496)1.98316880
119Nonimmune hydrops fetalis (HP:0001790)1.97954519
120Acne (HP:0001061)1.96819689
121Abnormal delivery (HP:0001787)1.94213511
122Chondrocalcinosis (HP:0000934)1.93524208
123Insulin-resistant diabetes mellitus (HP:0000831)1.92084252
124Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91734516
125Malnutrition (HP:0004395)1.91213034
126Urinary glycosaminoglycan excretion (HP:0003541)1.91193243
127Mucopolysacchariduria (HP:0008155)1.91193243
128Abnormality of transition element cation homeostasis (HP:0011030)1.91037738
129Abnormality of lateral ventricle (HP:0030047)1.91027210
130Polyphagia (HP:0002591)1.90782279
131Decreased subcutaneous fat (HP:0001002)1.90591507
132Basal ganglia calcification (HP:0002135)1.89982988
133Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.88322637
134Supranuclear gaze palsy (HP:0000605)1.88320946
135Memory impairment (HP:0002354)1.88027046
136Beaking of vertebral bodies (HP:0004568)1.87498172
137Pathologic fracture (HP:0002756)1.86403694
138Neonatal hypoglycemia (HP:0001998)1.86201953
139Growth hormone excess (HP:0000845)1.85963477
140Polyneuropathy (HP:0001271)1.85950720
141Vascular tortuosity (HP:0004948)1.85875086
142Interstitial pulmonary disease (HP:0006530)1.85267853
143Neonatal short-limb short stature (HP:0008921)1.83945126
144Abnormality of Sharpey fibers (HP:0100685)1.83838259
145Menorrhagia (HP:0000132)1.83467365
146Abnormality of calcium-phosphate metabolism (HP:0100530)1.82239951
147Ulnar deviation of the wrist (HP:0003049)1.82204103
148Abnormality of aromatic amino acid family metabolism (HP:0004338)1.81510463
149Distal lower limb amyotrophy (HP:0008944)1.81280356
150Abnormality of polysaccharide metabolism (HP:0011012)1.81134111
151Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81134111
152Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81134111
153Ketoacidosis (HP:0001993)1.80027000
154Joint stiffness (HP:0001387)1.78385723
155Hyperparathyroidism (HP:0000843)1.76601579
156Pulmonary artery stenosis (HP:0004415)1.76402095
157Hyperlipoproteinemia (HP:0010980)1.76288730
158Abnormality of the vasculature of the conjunctiva (HP:0008054)1.76119390
159Joint laxity (HP:0001388)1.75982750
160Ectopia lentis (HP:0001083)1.75955367
161Myoglobinuria (HP:0002913)1.75877411
162Round ear (HP:0100830)1.74751116
163Persistence of primary teeth (HP:0006335)1.72319236
164Muscle fiber inclusion bodies (HP:0100299)1.71678952
165Alopecia of scalp (HP:0002293)1.71071867
166Thin ribs (HP:0000883)1.70155272
167Dysostosis multiplex (HP:0000943)1.69929458
168Urinary incontinence (HP:0000020)1.69726391
169Hyperextensible skin (HP:0000974)1.69673871
170Hepatoblastoma (HP:0002884)1.68764934
171Agitation (HP:0000713)1.68592549
172J-shaped sella turcica (HP:0002680)1.67949360
173Myocardial infarction (HP:0001658)1.67118866
174Hypoalphalipoproteinemia (HP:0003233)1.66334180
175Cardiomegaly (HP:0001640)1.66191194
176Abnormality of the intrinsic pathway (HP:0010989)1.65473969
177Knee flexion contracture (HP:0006380)1.65440813
178Hemoptysis (HP:0002105)1.64073562
179Tarsal synostosis (HP:0008368)1.63508267
180Hepatosplenomegaly (HP:0001433)1.63036575
181Hypokalemia (HP:0002900)1.62307468
182Pulmonary embolism (HP:0002204)1.62046302
183Abnormality of the distal phalanges of the toes (HP:0010182)1.62015541
184Osteopenia (HP:0000938)1.61621148
185Congenital glaucoma (HP:0001087)1.61249034
186Nemaline bodies (HP:0003798)1.60638152
187Hyperuricemia (HP:0002149)1.60462948
188Increased purine levels (HP:0004368)1.60462948
189Joint swelling (HP:0001386)1.58839142
190Obstructive lung disease (HP:0006536)1.57131480

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK5.39934385
2MAPK154.90066550
3NME24.64698607
4ERN13.97982228
5EPHA33.54485852
6TAOK12.88459300
7RIPK12.43926355
8MAP2K22.29457603
9INSRR2.26401332
10TIE11.99362725
11PIK3CG1.90236202
12TESK11.87614419
13MAP3K31.86425258
14PIM21.85461949
15PRKCH1.79048613
16BCKDK1.71605945
17ABL21.68601570
18PASK1.62616198
19TGFBR21.61582476
20BLK1.60020434
21TYRO31.59077713
22EPHB11.56158562
23FER1.50755199
24LIMK11.48568085
25TRIB31.47958536
26TTN1.39499326
27IRAK41.38860301
28MYLK1.37647131
29TXK1.33397752
30EPHB21.31602702
31TAOK21.31588383
32FGR1.28762103
33PKN11.28745969
34PTK21.28671437
35FGFR41.28142740
36ICK1.26779019
37OBSCN1.25396593
38IRAK31.23069505
39MAP2K11.22922764
40MAP2K61.21132355
41TBK11.20044928
42MAP3K141.19422765
43KDR1.17702172
44MAP3K51.16550020
45PTK2B1.13318419
46MAP2K31.10265828
47PAK21.08669098
48MAPKAPK31.08449705
49ERBB31.07454336
50DYRK31.07298375
51PRKG21.06571492
52EPHA21.01315329
53HIPK21.00371949
54DAPK20.98697065
55PRKD30.98626575
56CHUK0.98537285
57PAK30.96770806
58TYK20.96562209
59PTK60.94230244
60RPS6KA40.93218033
61MAP4K10.92856403
62IRAK10.92123754
63PRKD20.89350996
64ARAF0.84424862
65TGFBR10.83950225
66CAMKK20.82499243
67IKBKB0.82238219
68SIK30.81825644
69STK38L0.77386842
70PIK3CA0.77353930
71PHKG20.77151523
72PHKG10.77151523
73CSK0.76110637
74IRAK20.75898928
75DAPK30.75059593
76MAPK40.74821412
77CAMK1D0.73220964
78JAK30.73125710
79PINK10.72390546
80WNK40.71797875
81SIK20.71129954
82RPS6KL10.70699249
83RPS6KC10.70699249
84SGK20.70618026
85SGK2230.70614780
86SGK4940.70614780
87MOS0.68617734
88PRPF4B0.68095240
89ACVR1B0.67764888
90LYN0.66162844
91MAPK70.65744707
92PDGFRA0.64958365
93MARK20.63149421
94CDK30.62941559
95GSK3A0.62481637
96RPS6KA60.61882078
97MAP3K110.60932309
98NEK60.58621509
99DYRK1B0.58323591
100ADRBK20.57723208
101LMTK20.57712950
102MAPKAPK20.56740481
103WNK30.56398165
104RPS6KA20.56109621
105NLK0.53061257
106CDK90.52769261
107JAK10.52266887
108DDR20.51846592
109JAK20.50977743
110MARK10.50639321
111MAP3K130.50025909
112EPHA40.49687145
113FRK0.49323417
114TNK20.48947706
115LATS10.48890617
116MATK0.48291563
117PRKAA20.48089822
118BMPR20.47336135
119SIK10.47318438
120LATS20.47060065
121MUSK0.47036075
122RIPK40.46785123
123NME10.46155532
124NEK90.45619234
125PRKD10.45503768
126RPS6KA50.44403466
127LCK0.44291188
128MARK30.44167826
129CAMK2D0.44044680
130MAP4K20.43912788
131MAP3K10.43529906
132IKBKE0.43250705
133CAMK2G0.41575188
134SGK30.41400451
135CDC42BPA0.41080780
136TRPM70.40371491
137FGFR30.40326784
138ROCK10.39240866
139PIM10.37927878
140MAP3K100.36747191
141ERBB40.36597104
142PRKCE0.36476647
143GRK70.36356224
144RPS6KA10.35115897
145CAMK40.33856740
146ZAP700.33649061
147DMPK0.33506619
148PRKCZ0.32889707
149SYK0.32185765
150CSF1R0.31730745
151PRKACG0.29846212
152FES0.27860535
153MAP2K70.27793107
154NTRK30.27387871
155BTK0.26395225
156NTRK20.26218189
157BMX0.23444834
158PDPK10.22930562

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.87097664
2Protein export_Homo sapiens_hsa030603.91714455
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.83728840
4Staphylococcus aureus infection_Homo sapiens_hsa051502.76062692
5Sulfur metabolism_Homo sapiens_hsa009202.44429999
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.22229980
7ECM-receptor interaction_Homo sapiens_hsa045122.15961327
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.13982912
9Tryptophan metabolism_Homo sapiens_hsa003802.07466198
10Asthma_Homo sapiens_hsa053102.02688697
11Allograft rejection_Homo sapiens_hsa053301.90912099
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.89854603
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87396652
14Salmonella infection_Homo sapiens_hsa051321.82544711
15Other glycan degradation_Homo sapiens_hsa005111.79233998
16Malaria_Homo sapiens_hsa051441.78598329
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74893285
18Vibrio cholerae infection_Homo sapiens_hsa051101.69455867
19Bladder cancer_Homo sapiens_hsa052191.65911361
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.63697070
21Galactose metabolism_Homo sapiens_hsa000521.57948396
22Lysosome_Homo sapiens_hsa041421.57125034
23Protein digestion and absorption_Homo sapiens_hsa049741.54382807
24African trypanosomiasis_Homo sapiens_hsa051431.53946029
25Tuberculosis_Homo sapiens_hsa051521.52766622
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.44421373
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43232424
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39490350
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.38721895
30Prion diseases_Homo sapiens_hsa050201.38671650
31Starch and sucrose metabolism_Homo sapiens_hsa005001.38645270
32Graft-versus-host disease_Homo sapiens_hsa053321.37326613
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36934608
34Autoimmune thyroid disease_Homo sapiens_hsa053201.36793475
35Focal adhesion_Homo sapiens_hsa045101.34493048
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.31556433
37TNF signaling pathway_Homo sapiens_hsa046681.30495718
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27210863
39Complement and coagulation cascades_Homo sapiens_hsa046101.26897128
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22711109
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22246157
42Collecting duct acid secretion_Homo sapiens_hsa049661.21446157
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20221552
44Selenocompound metabolism_Homo sapiens_hsa004501.16744183
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11058927
46Amoebiasis_Homo sapiens_hsa051461.10958015
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07184137
48Sulfur relay system_Homo sapiens_hsa041221.06541218
49Chemical carcinogenesis_Homo sapiens_hsa052041.06508512
50Rheumatoid arthritis_Homo sapiens_hsa053231.05989590
51Type I diabetes mellitus_Homo sapiens_hsa049401.05981919
52Insulin secretion_Homo sapiens_hsa049111.03767201
53Dilated cardiomyopathy_Homo sapiens_hsa054141.03226994
54Folate biosynthesis_Homo sapiens_hsa007901.02188432
55Influenza A_Homo sapiens_hsa051641.01540022
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01155367
57Phagosome_Homo sapiens_hsa041450.99616041
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96977410
59Fatty acid degradation_Homo sapiens_hsa000710.96204517
60Legionellosis_Homo sapiens_hsa051340.96055637
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95977050
62Circadian rhythm_Homo sapiens_hsa047100.95851792
63Leishmaniasis_Homo sapiens_hsa051400.94643227
64Prolactin signaling pathway_Homo sapiens_hsa049170.93648545
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93480929
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92916477
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91682212
68Proteoglycans in cancer_Homo sapiens_hsa052050.90857455
69TGF-beta signaling pathway_Homo sapiens_hsa043500.87218128
70N-Glycan biosynthesis_Homo sapiens_hsa005100.85411365
71Mineral absorption_Homo sapiens_hsa049780.85136300
72Hepatitis C_Homo sapiens_hsa051600.84957445
73Arachidonic acid metabolism_Homo sapiens_hsa005900.83518433
74Caffeine metabolism_Homo sapiens_hsa002320.82120477
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80969509
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79655589
77Regulation of autophagy_Homo sapiens_hsa041400.78832431
78Osteoclast differentiation_Homo sapiens_hsa043800.77039168
79Glutathione metabolism_Homo sapiens_hsa004800.76448656
80VEGF signaling pathway_Homo sapiens_hsa043700.76291967
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75311840
82Phenylalanine metabolism_Homo sapiens_hsa003600.75231614
83Viral myocarditis_Homo sapiens_hsa054160.74708862
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74469396
85Pertussis_Homo sapiens_hsa051330.73134523
86Chemokine signaling pathway_Homo sapiens_hsa040620.70387014
87Arginine and proline metabolism_Homo sapiens_hsa003300.69476724
88Toxoplasmosis_Homo sapiens_hsa051450.67472491
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65878271
90* Apoptosis_Homo sapiens_hsa042100.65345009
91Cocaine addiction_Homo sapiens_hsa050300.64796685
92HTLV-I infection_Homo sapiens_hsa051660.63795256
93Insulin resistance_Homo sapiens_hsa049310.63629990
94Antigen processing and presentation_Homo sapiens_hsa046120.63168505
95Linoleic acid metabolism_Homo sapiens_hsa005910.62005568
96Hippo signaling pathway_Homo sapiens_hsa043900.61305312
97Type II diabetes mellitus_Homo sapiens_hsa049300.60838089
98Small cell lung cancer_Homo sapiens_hsa052220.60027112
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59553884
100Basal cell carcinoma_Homo sapiens_hsa052170.58054710
101Herpes simplex infection_Homo sapiens_hsa051680.55999961
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55101394
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54963239
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.52748509
105Tyrosine metabolism_Homo sapiens_hsa003500.52607844
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52041230
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51816926
108Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50996217
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.49570252
110Butanoate metabolism_Homo sapiens_hsa006500.48870999
111Peroxisome_Homo sapiens_hsa041460.47606182
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46687578
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44815948
114Retinol metabolism_Homo sapiens_hsa008300.44684839
115PPAR signaling pathway_Homo sapiens_hsa033200.44632999
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.44494417
117Histidine metabolism_Homo sapiens_hsa003400.44101220
118Measles_Homo sapiens_hsa051620.43873513
119Sphingolipid metabolism_Homo sapiens_hsa006000.43662125
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42677875
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41130546
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40433198
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.40224850
124Adherens junction_Homo sapiens_hsa045200.39228289
125Notch signaling pathway_Homo sapiens_hsa043300.39169496
126Thyroid hormone synthesis_Homo sapiens_hsa049180.39138921
127Shigellosis_Homo sapiens_hsa051310.38567444
128Hematopoietic cell lineage_Homo sapiens_hsa046400.38561461
129Arginine biosynthesis_Homo sapiens_hsa002200.38351346
130Prostate cancer_Homo sapiens_hsa052150.38082337
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37775801
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.37720546
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.37670539
134* FoxO signaling pathway_Homo sapiens_hsa040680.37200510
135Synaptic vesicle cycle_Homo sapiens_hsa047210.37102795
136Melanoma_Homo sapiens_hsa052180.36031611
137* p53 signaling pathway_Homo sapiens_hsa041150.35357238
138T cell receptor signaling pathway_Homo sapiens_hsa046600.35174349
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34775444
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.34692079
141Hepatitis B_Homo sapiens_hsa051610.34677285
142Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34106669
143Cyanoamino acid metabolism_Homo sapiens_hsa004600.33856411
144Ovarian steroidogenesis_Homo sapiens_hsa049130.33424771
145B cell receptor signaling pathway_Homo sapiens_hsa046620.31822554
146Chronic myeloid leukemia_Homo sapiens_hsa052200.31510575
147Epstein-Barr virus infection_Homo sapiens_hsa051690.31360537
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.28750429
149beta-Alanine metabolism_Homo sapiens_hsa004100.26738198

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