GAGE12B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleoside monophosphate metabolic process (GO:0009129)9.57553956
2diterpenoid biosynthetic process (GO:0016102)8.39316059
3CTP metabolic process (GO:0046036)7.62108789
4CTP biosynthetic process (GO:0006241)7.62108789
5keratinocyte development (GO:0003334)7.36774109
6pentose-phosphate shunt (GO:0006098)7.27203358
7pentose metabolic process (GO:0019321)7.22196674
8terpenoid biosynthetic process (GO:0016114)7.11305041
9pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)7.05304100
10regulation of glycogen (starch) synthase activity (GO:2000465)6.91523327
11pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)6.71731389
12NADPH regeneration (GO:0006740)6.63083514
13pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)5.99004396
14activation of NF-kappaB-inducing kinase activity (GO:0007250)5.91243532
15regulation of activation of Janus kinase activity (GO:0010533)5.85831189
16glucose catabolic process (GO:0006007)5.61541383
17pyrimidine nucleoside triphosphate metabolic process (GO:0009147)5.51654927
18purine nucleotide salvage (GO:0032261)5.36267208
19pyrimidine ribonucleoside biosynthetic process (GO:0046132)5.25193346
20negative regulation of keratinocyte proliferation (GO:0010839)5.24115256
21cellular metabolic compound salvage (GO:0043094)5.23028638
22translational termination (GO:0006415)5.15710254
23viral transcription (GO:0019083)5.15373284
24pyrimidine ribonucleotide biosynthetic process (GO:0009220)5.11597672
25peptidyl-lysine dimethylation (GO:0018027)4.96886229
26tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.94092572
27RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.94092572
28pyrimidine ribonucleotide metabolic process (GO:0009218)4.72135975
29positive regulation of NIK/NF-kappaB signaling (GO:1901224)4.64620701
30translational elongation (GO:0006414)4.64127007
31interleukin-6-mediated signaling pathway (GO:0070102)4.51295521
32negative regulation of JAK-STAT cascade (GO:0046426)4.41481865
33peptidyl-cysteine modification (GO:0018198)4.27109400
34retinal metabolic process (GO:0042574)4.22151238
35response to folic acid (GO:0051593)4.16529598
36pyrimidine nucleotide biosynthetic process (GO:0006221)4.13403529
37neutrophil mediated immunity (GO:0002446)4.10777000
38centrosome duplication (GO:0051298)4.09604019
39DNA ligation (GO:0006266)4.06456878
40cellular protein complex disassembly (GO:0043624)4.06412355
41establishment of skin barrier (GO:0061436)3.97638558
42regulation of NIK/NF-kappaB signaling (GO:1901222)3.89677087
43response to nitric oxide (GO:0071731)3.87570031
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.81540303
45pyrimidine ribonucleoside metabolic process (GO:0046131)3.80949838
46DNA synthesis involved in DNA repair (GO:0000731)3.73326382
47cotranslational protein targeting to membrane (GO:0006613)3.73290241
48catecholamine transport (GO:0051937)3.73059705
49pyrimidine nucleoside biosynthetic process (GO:0046134)3.68936426
50protein-chromophore linkage (GO:0018298)3.67964812
51protein targeting to ER (GO:0045047)3.65716486
52protein complex disassembly (GO:0043241)3.62445935
53negative regulation of stem cell proliferation (GO:2000647)3.60418625
54viral life cycle (GO:0019058)3.51085711
55positive regulation of epidermal cell differentiation (GO:0045606)3.49235452
56establishment of protein localization to endoplasmic reticulum (GO:0072599)3.49060984
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.43512267
58NADP metabolic process (GO:0006739)3.43174440
59macromolecular complex disassembly (GO:0032984)3.40571794
60protein localization to endoplasmic reticulum (GO:0070972)3.36524503
61grooming behavior (GO:0007625)3.28941035
62DNA dealkylation (GO:0035510)3.27733774
63negative regulation of interleukin-8 production (GO:0032717)3.21507337
64extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)3.13501222
65pyrimidine-containing compound biosynthetic process (GO:0072528)3.11590014
66ribosomal small subunit assembly (GO:0000028)3.06507915
67myeloid leukocyte mediated immunity (GO:0002444)3.05124860
68regulation of water loss via skin (GO:0033561)3.03536556
69AMP metabolic process (GO:0046033)3.02937606
70tRNA modification (GO:0006400)3.00786704
71positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.94118152
72neutrophil activation involved in immune response (GO:0002283)2.92320544
73pyrimidine nucleotide metabolic process (GO:0006220)2.92060192
74translesion synthesis (GO:0019985)2.91219502
75isoprenoid biosynthetic process (GO:0008299)2.89705553
76purine nucleobase biosynthetic process (GO:0009113)2.87684251
77monocyte chemotaxis (GO:0002548)2.85071597
78daunorubicin metabolic process (GO:0044597)2.82262484
79polyketide metabolic process (GO:0030638)2.82262484
80doxorubicin metabolic process (GO:0044598)2.82262484
81heparin metabolic process (GO:0030202)2.81169830
82heparin biosynthetic process (GO:0030210)2.81169830
83retinoic acid metabolic process (GO:0042573)2.76860036
84organ or tissue specific immune response (GO:0002251)2.75939226
85regulation of hypersensitivity (GO:0002883)2.74206794
86translational initiation (GO:0006413)2.70139296
87peptidyl-lysine trimethylation (GO:0018023)2.66532275
88regulation of mammary gland epithelial cell proliferation (GO:0033599)2.65406911
89cytokinetic process (GO:0032506)2.65406184
90ribonucleoside triphosphate biosynthetic process (GO:0009201)2.60604287
91aminoglycoside antibiotic metabolic process (GO:0030647)2.59393827
92pyrimidine nucleoside salvage (GO:0043097)13.3286157
93pyrimidine-containing compound salvage (GO:0008655)13.3286157
94nucleotide salvage (GO:0043173)12.8095086
95nucleoside salvage (GO:0043174)11.8227193
96pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)11.7943940
97UMP biosynthetic process (GO:0006222)11.7943940
98pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)11.7943940
99UMP metabolic process (GO:0046049)11.7943940
100pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)10.0445648

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IKZF1_21737484_ChIP-ChIP_HCT116_Human4.04757237
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.95255888
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.87956114
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.75976433
5EZH2_22144423_ChIP-Seq_EOC_Human3.64714947
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80127652
7BMI1_23680149_ChIP-Seq_NPCS_Mouse2.58276636
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.55658641
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53624820
10POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.51841911
11IGF1R_20145208_ChIP-Seq_DFB_Human2.41075803
12RUNX_20019798_ChIP-Seq_JUKART_Human2.37098908
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.20170861
14TP53_20018659_ChIP-ChIP_R1E_Mouse2.14636314
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.10495530
16TAF15_26573619_Chip-Seq_HEK293_Human2.10008769
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09559569
18PCGF2_27294783_Chip-Seq_NPCs_Mouse2.06286917
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.97940322
20PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.95766446
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.95537399
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94608256
23P53_22127205_ChIP-Seq_FIBROBLAST_Human1.94117584
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93772065
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.91374203
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90513969
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90513969
28POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.87230338
29IRF1_19129219_ChIP-ChIP_H3396_Human1.85286518
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83625400
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.82034977
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.81151407
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.80279083
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.73462015
35GATA1_26923725_Chip-Seq_HPCs_Mouse1.70550082
36RNF2_27304074_Chip-Seq_NSC_Mouse1.67747989
37REST_21632747_ChIP-Seq_MESCs_Mouse1.58957064
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56403746
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54833235
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.49939340
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49651280
42PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.48286998
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44634024
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44634024
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44634024
46TP53_22573176_ChIP-Seq_HFKS_Human1.44141703
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43536730
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40744925
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37861999
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.34642276
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.29344258
52KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26091001
53ERA_21632823_ChIP-Seq_H3396_Human1.20177065
54FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17925755
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14497615
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13017036
57SMC4_20622854_ChIP-Seq_HELA_Human1.11925605
58JUN_21703547_ChIP-Seq_K562_Human1.11378084
59MYC_19915707_ChIP-ChIP_AK7_Human1.05942251
60CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04889295
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02495587
62HTT_18923047_ChIP-ChIP_STHdh_Human1.02152278
63GBX2_23144817_ChIP-Seq_PC3_Human1.01378433
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01043927
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.00575071
66NCOR_22424771_ChIP-Seq_293T_Human1.00078503
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98653012
68MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96953440
69ELK1_19687146_ChIP-ChIP_HELA_Human0.96365854
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96026606
71SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95703493
72FUS_26573619_Chip-Seq_HEK293_Human0.95115348
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94813998
74BCAT_22108803_ChIP-Seq_LS180_Human0.94284918
75POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93678882
76P300_19829295_ChIP-Seq_ESCs_Human0.92841374
77LXR_22292898_ChIP-Seq_THP-1_Human0.92775368
78P53_21459846_ChIP-Seq_SAOS-2_Human0.92608964
79CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90293712
80P68_20966046_ChIP-Seq_HELA_Human0.89401829
81EZH2_27294783_Chip-Seq_NPCs_Mouse0.88849908
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88133846
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87735076
84ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86059829
85NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85465124
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84237597
87E2F7_22180533_ChIP-Seq_HELA_Human0.83543822
88SMAD3_21741376_ChIP-Seq_ESCs_Human0.82955863
89WDR5_24793694_ChIP-Seq_LNCAP_Human0.82720571
90CRX_20693478_ChIP-Seq_RETINA_Mouse0.82299008
91RBPJ_21746931_ChIP-Seq_IB4_Human0.82221572
92ZNF274_21170338_ChIP-Seq_K562_Hela0.82208925
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81852771
94CBP_20019798_ChIP-Seq_JUKART_Human0.81852771
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81710555
96RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.81643509
97P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.81573525
98TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81513531
99CTCF_20526341_ChIP-Seq_ESCs_Human0.80350570
100SMAD3_21741376_ChIP-Seq_EPCs_Human0.80320523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.08904244
2MP0002163_abnormal_gland_morphology4.58719418
3MP0006292_abnormal_olfactory_placode4.51747926
4MP0002234_abnormal_pharynx_morphology3.53477759
5MP0001873_stomach_inflammation3.41188247
6MP0003724_increased_susceptibility_to3.17415335
7MP0001346_abnormal_lacrimal_gland3.04721162
8MP0003646_muscle_fatigue3.01933327
9MP0001348_abnormal_lacrimal_gland2.98398080
10MP0006082_CNS_inflammation2.89966321
11MP0000538_abnormal_urinary_bladder2.58152016
12MP0006276_abnormal_autonomic_nervous2.57730063
13MP0005379_endocrine/exocrine_gland_phen2.54097629
14MP0008875_abnormal_xenobiotic_pharmacok2.40715858
15MP0005360_urolithiasis2.36945392
16MP0009379_abnormal_foot_pigmentation2.34730669
17MP0005423_abnormal_somatic_nervous2.22741434
18MP0003787_abnormal_imprinting2.15998345
19MP0001293_anophthalmia2.06856742
20MP0005310_abnormal_salivary_gland2.01612267
21MP0002822_catalepsy1.88603624
22MP0001986_abnormal_taste_sensitivity1.72767340
23MP0003279_aneurysm1.70747312
24MP0001663_abnormal_digestive_system1.66686817
25MP0008789_abnormal_olfactory_epithelium1.62879176
26MP0008872_abnormal_physiological_respon1.59840366
27MP0001664_abnormal_digestion1.53607645
28MP0003119_abnormal_digestive_system1.52368531
29MP0003123_paternal_imprinting1.46710507
30MP0005167_abnormal_blood-brain_barrier1.40599083
31MP0000383_abnormal_hair_follicle1.36272516
32MP0001756_abnormal_urination1.36182670
33MP0002876_abnormal_thyroid_physiology1.31610994
34MP0005499_abnormal_olfactory_system1.28977796
35MP0005394_taste/olfaction_phenotype1.28977796
36MP0005381_digestive/alimentary_phenotyp1.24824841
37MP0002932_abnormal_joint_morphology1.22958426
38MP0010155_abnormal_intestine_physiology1.19014077
39MP0010329_abnormal_lipoprotein_level1.12692215
40MP0002933_joint_inflammation1.11358496
41MP0010386_abnormal_urinary_bladder1.10525184
42MP0002095_abnormal_skin_pigmentation1.08939628
43MP0008995_early_reproductive_senescence1.08630008
44MP0002233_abnormal_nose_morphology1.07474553
45MP0003866_abnormal_defecation1.02954316
46MP0001529_abnormal_vocalization1.02270092
47MP0004885_abnormal_endolymph1.02054563
48MP0000049_abnormal_middle_ear1.01347997
49MP0003878_abnormal_ear_physiology1.01077303
50MP0005377_hearing/vestibular/ear_phenot1.01077303
51MP0000631_abnormal_neuroendocrine_gland0.98545810
52MP0005000_abnormal_immune_tolerance0.98189092
53MP0002837_dystrophic_cardiac_calcinosis0.92342361
54MP0003011_delayed_dark_adaptation0.92122823
55MP0000613_abnormal_salivary_gland0.91584712
56MP0005503_abnormal_tendon_morphology0.91020131
57MP0002653_abnormal_ependyma_morphology0.90605739
58MP0000569_abnormal_digit_pigmentation0.89435476
59MP0000955_abnormal_spinal_cord0.87576142
60MP0000778_abnormal_nervous_system0.85057073
61MP0001286_abnormal_eye_development0.84740087
62MP0008775_abnormal_heart_ventricle0.83022802
63MP0005332_abnormal_amino_acid0.82505629
64MP0001905_abnormal_dopamine_level0.82283174
65MP0009785_altered_susceptibility_to0.77799719
66MP0003121_genomic_imprinting0.76250282
67MP0001944_abnormal_pancreas_morphology0.75436397
68MP0004145_abnormal_muscle_electrophysio0.75277647
69MP0002272_abnormal_nervous_system0.74777344
70MP0003136_yellow_coat_color0.73971993
71MP0001485_abnormal_pinna_reflex0.73885392
72MP0002752_abnormal_somatic_nervous0.73026040
73MP0009745_abnormal_behavioral_response0.72870348
74MP0000467_abnormal_esophagus_morphology0.70578761
75MP0003943_abnormal_hepatobiliary_system0.69747134
76MP0000372_irregular_coat_pigmentation0.69544922
77MP0005551_abnormal_eye_electrophysiolog0.69199374
78MP0002092_abnormal_eye_morphology0.67861482
79MP0000470_abnormal_stomach_morphology0.67550304
80MP0002160_abnormal_reproductive_system0.67192241
81MP0005389_reproductive_system_phenotype0.66459789
82MP0003315_abnormal_perineum_morphology0.66087683
83MP0009250_abnormal_appendicular_skeleto0.66048558
84MP0001984_abnormal_olfaction0.66000898
85MP0002638_abnormal_pupillary_reflex0.65843644
86MP0005645_abnormal_hypothalamus_physiol0.65732646
87MP0005391_vision/eye_phenotype0.65106924
88MP0010678_abnormal_skin_adnexa0.65020913
89MP0002697_abnormal_eye_size0.64908273
90MP0002184_abnormal_innervation0.62393361
91MP0004142_abnormal_muscle_tone0.62362096
92MP0008873_increased_physiological_sensi0.62336386
93MP0002102_abnormal_ear_morphology0.59615452
94MP0005257_abnormal_intraocular_pressure0.59571863
95MP0000427_abnormal_hair_cycle0.59183765
96MP0005195_abnormal_posterior_eye0.58471664
97MP0004859_abnormal_synaptic_plasticity0.57775063
98MP0002735_abnormal_chemical_nociception0.57496023
99MP0003122_maternal_imprinting0.56620084
100MP0004130_abnormal_muscle_cell0.56113102

Predicted human phenotypes

RankGene SetZ-score
1Difficulty running (HP:0009046)8.98416366
2Hip dysplasia (HP:0001385)8.26266096
3Achilles tendon contracture (HP:0001771)7.53663331
4Abnormality of the Achilles tendon (HP:0005109)6.87613041
5Hip contracture (HP:0003273)6.46872627
6Hypoplasia of the pons (HP:0012110)6.23510586
7Abnormality of the pons (HP:0007361)5.52459458
8Limited hip movement (HP:0008800)5.26448381
9Opisthotonus (HP:0002179)5.06590266
10Poor suck (HP:0002033)4.89629103
11Knee flexion contracture (HP:0006380)3.92319780
12Scapular winging (HP:0003691)3.87003543
13Restlessness (HP:0000711)3.72539861
14Hyperglycinemia (HP:0002154)3.68589328
15Impaired smooth pursuit (HP:0007772)3.53585940
16Dyskinesia (HP:0100660)3.52095252
17Poor eye contact (HP:0000817)3.22813753
18Increased hepatocellular lipid droplets (HP:0006565)3.10316398
19Asplenia (HP:0001746)2.90387763
20Gowers sign (HP:0003391)2.89752535
21Thoracolumbar scoliosis (HP:0002944)2.85481549
22Spondylolisthesis (HP:0003302)2.84185475
23Progressive microcephaly (HP:0000253)2.82823122
24Aplasia/Hypoplasia of the spleen (HP:0010451)2.81198368
25Parakeratosis (HP:0001036)2.74853957
26Abnormality of the periventricular white matter (HP:0002518)2.69705163
27Renal Fanconi syndrome (HP:0001994)2.68958956
28Short femoral neck (HP:0100864)2.67193044
29Waddling gait (HP:0002515)2.66932629
30Pancreatic fibrosis (HP:0100732)2.66874067
31Lipid accumulation in hepatocytes (HP:0006561)2.56938662
32Abnormality of ocular smooth pursuit (HP:0000617)2.55400637
33Abnormality of cells of the erythroid lineage (HP:0012130)2.52042729
34Severe global developmental delay (HP:0011344)2.47596267
35Sacral dimple (HP:0000960)2.44765861
36Fasciculations (HP:0002380)2.44463978
37Hypoplasia of the brainstem (HP:0002365)2.42203465
38Aplasia/Hypoplasia of the brainstem (HP:0007362)2.42203465
39Tetraplegia (HP:0002445)2.38124508
40Increased intramyocellular lipid droplets (HP:0012240)2.37423628
41Abnormality of the shoulder girdle musculature (HP:0001435)2.36276252
42Impaired social interactions (HP:0000735)2.33537980
43Abnormal social behavior (HP:0012433)2.33537980
44Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.31017076
45Potter facies (HP:0002009)2.26362999
46Facial shape deformation (HP:0011334)2.26362999
47Abnormal number of erythroid precursors (HP:0012131)2.24912412
48Symphalangism affecting the phalanges of the hand (HP:0009773)2.20524174
49Delayed epiphyseal ossification (HP:0002663)2.18278001
50Prominent metopic ridge (HP:0005487)2.15222438
51Abnormal biliary tract physiology (HP:0012439)2.13554872
52Bile duct proliferation (HP:0001408)2.13554872
53Abnormality of the metopic suture (HP:0005556)2.13541922
54Small epiphyses (HP:0010585)2.12725038
55Abnormality of the anterior horn cell (HP:0006802)2.12653660
56Degeneration of anterior horn cells (HP:0002398)2.12653660
57Abnormal drinking behavior (HP:0030082)2.11100182
58Polydipsia (HP:0001959)2.11100182
59Nasal speech (HP:0001611)2.06133748
60Mesomelia (HP:0003027)2.05778245
61Female pseudohermaphroditism (HP:0010458)2.05167180
62Abnormality of the phalanges of the 2nd finger (HP:0009541)2.04836019
63Supernumerary spleens (HP:0009799)2.04692900
64Tubular atrophy (HP:0000092)2.03326922
65Brushfield spots (HP:0001088)2.02261720
66Abnormality of the vocal cords (HP:0008777)2.00506224
67Autoimmune thrombocytopenia (HP:0001973)2.00471664
68Genetic anticipation (HP:0003743)1.98380494
69Abnormality of the lower motor neuron (HP:0002366)1.95334036
70Ulnar deviation of the wrist (HP:0003049)1.94271344
71Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93184931
72Short 4th metacarpal (HP:0010044)1.93184931
73Wide intermamillary distance (HP:0006610)1.92000120
74Exertional dyspnea (HP:0002875)1.89925144
75Aplasia/hypoplasia of the femur (HP:0005613)1.87070054
76Death in childhood (HP:0003819)1.86529124
77Tubulointerstitial fibrosis (HP:0005576)1.85267244
78Molar tooth sign on MRI (HP:0002419)1.83427754
79Abnormality of midbrain morphology (HP:0002418)1.83427754
80Congenital, generalized hypertrichosis (HP:0004540)1.81936124
81Chronic hepatic failure (HP:0100626)1.79224072
82Increased muscle lipid content (HP:0009058)1.79134450
83Abnormality of the fingertips (HP:0001211)1.78762912
84Abnormality of the musculature of the hand (HP:0001421)1.78650223
85Supranuclear gaze palsy (HP:0000605)1.75996793
86Myokymia (HP:0002411)1.74111022
87Adrenal hypoplasia (HP:0000835)1.71554287
88Macrocytic anemia (HP:0001972)1.71254225
89Respiratory difficulties (HP:0002880)1.70469232
90Mitochondrial inheritance (HP:0001427)1.68933565
91Abnormality of the proximal phalanges of the hand (HP:0009834)1.68893756
92Primary adrenal insufficiency (HP:0008207)1.68285271
93Abnormality of chromosome stability (HP:0003220)1.67981590
94Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.67596905
95Hyperphosphaturia (HP:0003109)1.67050860
96Pancreatic cysts (HP:0001737)1.66537008
97Abnormality of renal resorption (HP:0011038)1.65415137
98Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.65380212
99Gonadal dysgenesis (HP:0000133)1.62324142
100Epiphyseal dysplasia (HP:0002656)1.62305337

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LIMK17.70263865
2MAP4K24.01094572
3MAP4K13.93441170
4TESK13.77555413
5WNK43.16785576
6NLK3.08767012
7TXK2.64214661
8SGK22.03350768
9BMPR1B1.89336408
10ACVR1B1.78881232
11CSF1R1.71109070
12SGK2231.60044431
13SGK4941.60044431
14PRKCG1.56123730
15NME11.55575805
16MINK11.54398029
17OXSR11.53927444
18CDC71.51532149
19PIK3CA1.51316608
20NTRK21.51294744
21DYRK1A1.49647474
22STK391.47449542
23INSRR1.41995137
24ADRBK21.39521324
25PLK21.38165235
26PKN11.32396645
27CDC42BPA1.30927020
28CSNK1G11.29181113
29PDK11.26266442
30CASK1.17389801
31TNIK1.14852536
32PRKD31.04064534
33CDK190.99334453
34TGFBR10.96571045
35SGK30.94661017
36RPS6KA50.84237907
37WNK30.82762115
38PRKCQ0.81834422
39PAK10.80894357
40LCK0.79201706
41MUSK0.77556122
42FRK0.77528871
43IKBKE0.76359693
44MAP2K70.75623864
45CSNK2A20.74911529
46LRRK20.74588126
47OBSCN0.74199643
48LYN0.71861806
49CSNK1A10.71415142
50EPHA40.70616454
51BRD40.70408908
52MAP3K90.63944149
53GRK10.63179993
54MAP3K40.63055131
55ITK0.61184774
56DYRK20.60863249
57MARK10.60244862
58FYN0.57695628
59ADRBK10.57006500
60CSNK2A10.56429988
61MST1R0.55951454
62MYLK0.54358684
63IGF1R0.53062207
64SYK0.52732892
65DYRK30.50797091
66PRKCA0.47780394
67MAPK150.47596630
68ICK0.46344017
69TIE10.46048685
70PDPK10.45837397
71WNK10.45716504
72MAPK40.45489426
73SGK10.45031039
74MAPK30.43184369
75MAPK90.40817733
76ROCK20.39817593
77MAPK140.38817809
78RPS6KA60.38010730
79CDK50.37366771
80PIM20.36478732
81CDK150.36291710
82KDR0.35874447
83ROCK10.34413867
84RPS6KL10.34129074
85RPS6KC10.34129074
86IRAK20.33086431
87CDK140.32774642
88IKBKB0.32486526
89PRKACA0.32467661
90CDK180.31673278
91MAP2K60.31562937
92CDK20.30788756
93GSK3A0.29922661
94DYRK1B0.28611040
95NTRK30.28473200
96PAK30.28460862
97MATK0.27917463
98CDK11A0.27909095
99FES0.27887015
100MAPK130.27794144

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.77381680
2Pentose phosphate pathway_Homo sapiens_hsa000304.73067500
3Drug metabolism - other enzymes_Homo sapiens_hsa009834.18533639
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.45307339
5Hematopoietic cell lineage_Homo sapiens_hsa046402.23199875
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.19826529
7Sulfur relay system_Homo sapiens_hsa0412210.2276088
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.97713860
9Pyrimidine metabolism_Homo sapiens_hsa002401.75561362
10Butanoate metabolism_Homo sapiens_hsa006501.55831773
11Measles_Homo sapiens_hsa051621.55635359
12Fat digestion and absorption_Homo sapiens_hsa049751.51147375
13Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.50352463
14Primary immunodeficiency_Homo sapiens_hsa053401.36056465
15Phototransduction_Homo sapiens_hsa047441.23089054
16Glycerolipid metabolism_Homo sapiens_hsa005611.12157922
17Cardiac muscle contraction_Homo sapiens_hsa042601.06309754
18Oxidative phosphorylation_Homo sapiens_hsa001900.98134530
19Olfactory transduction_Homo sapiens_hsa047400.94205599
20Nicotine addiction_Homo sapiens_hsa050330.93308324
21DNA replication_Homo sapiens_hsa030300.92354957
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91856379
23Apoptosis_Homo sapiens_hsa042100.90638005
24Parkinsons disease_Homo sapiens_hsa050120.89891834
25Malaria_Homo sapiens_hsa051440.84700834
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82480075
27Alzheimers disease_Homo sapiens_hsa050100.79900979
28Cysteine and methionine metabolism_Homo sapiens_hsa002700.77510943
29Carbon metabolism_Homo sapiens_hsa012000.76843536
30Retinol metabolism_Homo sapiens_hsa008300.73793057
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72985885
32Gastric acid secretion_Homo sapiens_hsa049710.71422645
33Thyroid cancer_Homo sapiens_hsa052160.70466046
34Taste transduction_Homo sapiens_hsa047420.68872706
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68682798
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68679378
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67855147
38Jak-STAT signaling pathway_Homo sapiens_hsa046300.67593987
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66751580
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64994110
41Influenza A_Homo sapiens_hsa051640.63671156
42Linoleic acid metabolism_Homo sapiens_hsa005910.63134328
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62894888
44Antigen processing and presentation_Homo sapiens_hsa046120.58579849
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58191571
46Chemical carcinogenesis_Homo sapiens_hsa052040.57263730
47Axon guidance_Homo sapiens_hsa043600.56510652
48Tryptophan metabolism_Homo sapiens_hsa003800.55496797
49Salivary secretion_Homo sapiens_hsa049700.55236801
50Autoimmune thyroid disease_Homo sapiens_hsa053200.50854455
51beta-Alanine metabolism_Homo sapiens_hsa004100.48941985
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47382125
53Hedgehog signaling pathway_Homo sapiens_hsa043400.47006745
54Caffeine metabolism_Homo sapiens_hsa002320.45478064
55Metabolic pathways_Homo sapiens_hsa011000.44985206
56Legionellosis_Homo sapiens_hsa051340.44374734
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43602056
58Systemic lupus erythematosus_Homo sapiens_hsa053220.43454628
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.42772196
60Morphine addiction_Homo sapiens_hsa050320.41832446
61GABAergic synapse_Homo sapiens_hsa047270.41328498
62Huntingtons disease_Homo sapiens_hsa050160.40602206
63Rheumatoid arthritis_Homo sapiens_hsa053230.40459855
64Sulfur metabolism_Homo sapiens_hsa009200.40372481
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40356682
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.40182366
67Serotonergic synapse_Homo sapiens_hsa047260.39653299
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38670264
69Graft-versus-host disease_Homo sapiens_hsa053320.35095205
70Peroxisome_Homo sapiens_hsa041460.34624226
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33479849
72Ovarian steroidogenesis_Homo sapiens_hsa049130.33100500
73Folate biosynthesis_Homo sapiens_hsa007900.32223016
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31953054
75Protein digestion and absorption_Homo sapiens_hsa049740.29894551
76Alcoholism_Homo sapiens_hsa050340.29522083
77Arachidonic acid metabolism_Homo sapiens_hsa005900.28874257
78Purine metabolism_Homo sapiens_hsa002300.28672580
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28420310
80Insulin secretion_Homo sapiens_hsa049110.27802360
81Basal cell carcinoma_Homo sapiens_hsa052170.27724766
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26995768
83Circadian entrainment_Homo sapiens_hsa047130.26330043
84African trypanosomiasis_Homo sapiens_hsa051430.23746044
85Type I diabetes mellitus_Homo sapiens_hsa049400.21514748
86Allograft rejection_Homo sapiens_hsa053300.21462421
87ECM-receptor interaction_Homo sapiens_hsa045120.21258830
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20369063
89Synaptic vesicle cycle_Homo sapiens_hsa047210.19980340
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19965444
91Glutamatergic synapse_Homo sapiens_hsa047240.19923518
92Steroid biosynthesis_Homo sapiens_hsa001000.19665481
93Cocaine addiction_Homo sapiens_hsa050300.19523015
94Calcium signaling pathway_Homo sapiens_hsa040200.19131541
95Dilated cardiomyopathy_Homo sapiens_hsa054140.18870002
96Starch and sucrose metabolism_Homo sapiens_hsa005000.17705275
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17101545
98T cell receptor signaling pathway_Homo sapiens_hsa046600.16951815
99Ether lipid metabolism_Homo sapiens_hsa005650.16858339
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16767429

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »