ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tyrosine metabolic process (GO:0006570)	8.82317172
2	melanin biosynthetic process (GO:0042438)	8.14084114
3	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	7.44335890
4	melanin metabolic process (GO:0006582)	7.37226238
5	homocysteine metabolic process (GO:0050667)	7.26054014
6	secondary metabolite biosynthetic process (GO:0044550)	6.47214661
7	midgut development (GO:0007494)	6.29001022
8	Golgi transport vesicle coating (GO:0048200)	6.24334900
9	COPI coating of Golgi vesicle (GO:0048205)	6.24334900
10	nuclear pore complex assembly (GO:0051292)	5.89981648
11	regulation of translational fidelity (GO:0006450)	5.61521519
12	positive regulation of receptor biosynthetic process (GO:0010870)	5.12812585
13	nuclear pore organization (GO:0006999)	5.11456602
14	urea cycle (GO:0000050)	5.10850666
15	citrulline biosynthetic process (GO:0019240)	4.97865156
16	urea metabolic process (GO:0019627)	4.71367667
17	negative regulation of complement activation (GO:0045916)	4.68524003
18	negative regulation of protein activation cascade (GO:2000258)	4.37188081
19	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	4.32704298
20	nitrogen cycle metabolic process (GO:0071941)	4.27932250
21	pore complex assembly (GO:0046931)	4.25622724
22	regulation of lipoprotein particle clearance (GO:0010984)	4.22787184
23	ribosomal large subunit biogenesis (GO:0042273)	4.19080677
24	protein retention in ER lumen (GO:0006621)	4.17457987
25	ribosomal small subunit biogenesis (GO:0042274)	4.06921293
26	establishment of apical/basal cell polarity (GO:0035089)	4.03581920
27	developmental pigmentation (GO:0048066)	3.97539083
28	glutamine metabolic process (GO:0006541)	3.90312436
29	citrulline metabolic process (GO:0000052)	3.87898596
30	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.86203487
31	folic acid metabolic process (GO:0046655)	3.83396160
32	L-phenylalanine metabolic process (GO:0006558)	3.81890285
33	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.81890285
34	formation of translation preinitiation complex (GO:0001731)	3.81646381
35	L-serine metabolic process (GO:0006563)	3.81302678
36	viral transcription (GO:0019083)	3.80977923
37	hepatocyte differentiation (GO:0070365)	3.80338431
38	cotranslational protein targeting to membrane (GO:0006613)	3.74759210
39	protein targeting to ER (GO:0045047)	3.72329280
40	translational termination (GO:0006415)	3.65139163
41	serine family amino acid biosynthetic process (GO:0009070)	3.60615637
42	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.60130193
43	ribonucleoprotein complex biogenesis (GO:0022613)	3.59646788
44	protein localization to endoplasmic reticulum (GO:0070972)	3.52359791
45	negative regulation of humoral immune response (GO:0002921)	3.41067129
46	proline biosynthetic process (GO:0006561)	3.39900376
47	basement membrane organization (GO:0071711)	3.37553666
48	aromatic amino acid family metabolic process (GO:0009072)	3.34828771
49	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	3.31990991
50	ribosome biogenesis (GO:0042254)	3.30154506
51	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	3.29185665
52	regulation of translational elongation (GO:0006448)	3.28457280
53	L-phenylalanine catabolic process (GO:0006559)	3.25345573
54	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.25345573
55	mitotic nuclear envelope disassembly (GO:0007077)	3.24912242
56	protein complex localization (GO:0031503)	3.24447662
57	activation of signaling protein activity involved in unfolded protein response (GO:0006987)	3.23922398
58	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.22001882
59	establishment of monopolar cell polarity (GO:0061162)	3.21876431
60	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.21876431
61	tRNA aminoacylation for protein translation (GO:0006418)	3.19699087
62	positive regulation of nuclease activity (GO:0032075)	3.18336753
63	peptidyl-proline hydroxylation (GO:0019511)	3.15666851
64	regulation of receptor biosynthetic process (GO:0010869)	3.14187683
65	nucleobase-containing small molecule interconversion (GO:0015949)	3.13869952
66	translational elongation (GO:0006414)	3.12900483
67	translational initiation (GO:0006413)	3.11277766
68	response to dexamethasone (GO:0071548)	3.05880265
69	regulation of complement activation (GO:0030449)	3.05442850
70	membrane disassembly (GO:0030397)	3.05111578
71	nuclear envelope disassembly (GO:0051081)	3.05111578
72	spliceosomal tri-snRNP complex assembly (GO:0000244)	3.04208148
73	amino acid activation (GO:0043038)	3.04139592
74	tRNA aminoacylation (GO:0043039)	3.04139592
75	DNA unwinding involved in DNA replication (GO:0006268)	3.04007311
76	positive regulation of urine volume (GO:0035810)	2.95276349
77	DNA strand elongation involved in DNA replication (GO:0006271)	2.93337101
78	pigment biosynthetic process (GO:0046148)	2.93211194
79	regulation of protein activation cascade (GO:2000257)	2.91540129
80	enteric nervous system development (GO:0048484)	2.91381191
81	cellular protein complex disassembly (GO:0043624)	2.90595805
82	endoplasmic reticulum unfolded protein response (GO:0030968)	2.89964364
83	regulation of regulatory T cell differentiation (GO:0045589)	2.89617075
84	non-recombinational repair (GO:0000726)	2.86848711
85	double-strand break repair via nonhomologous end joining (GO:0006303)	2.86848711
86	alpha-amino acid biosynthetic process (GO:1901607)	2.86283099
87	vesicle coating (GO:0006901)	2.85820463
88	morphogenesis of an epithelial sheet (GO:0002011)	2.85102584
89	DNA strand elongation (GO:0022616)	2.85019371
90	membrane protein ectodomain proteolysis (GO:0006509)	2.84744403
91	regulation of nuclease activity (GO:0032069)	2.84629965
92	biotin metabolic process (GO:0006768)	2.83854782
93	response to growth hormone (GO:0060416)	2.83363820
94	tricarboxylic acid cycle (GO:0006099)	2.81806200
95	protein hydroxylation (GO:0018126)	2.79238397
96	hair cycle (GO:0042633)	2.78400604
97	molting cycle (GO:0042303)	2.78400604
98	glycogen catabolic process (GO:0005980)	2.76860605
99	cellular protein complex localization (GO:0034629)	2.76591938
100	IMP biosynthetic process (GO:0006188)	2.75829740

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.68336002
2	ZNF263_19887448_ChIP-Seq_K562_Human	4.13155460
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.96330819
4	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.52826750
5	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.27376122
6	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.81674849
7	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.58246196
8	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.53543661
9	XRN2_22483619_ChIP-Seq_HELA_Human	2.45447010
10	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.39731344
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.21419847
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.16990796
13	TFEB_21752829_ChIP-Seq_HELA_Human	2.15804387
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.14142304
15	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.10070299
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.08458173
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.07037889
18	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.03900018
19	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.01863958
20	TTF2_22483619_ChIP-Seq_HELA_Human	1.99339659
21	KDM5A_27292631_Chip-Seq_BREAST_Human	1.95052410
22	DCP1A_22483619_ChIP-Seq_HELA_Human	1.93275137
23	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.84807555
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.84154938
25	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.80537759
26	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.80332327
27	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.79042836
28	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.78343536
29	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.77312722
30	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.75981597
31	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.73381234
32	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.65200036
33	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.60483995
34	CLOCK_20551151_ChIP-Seq_293T_Human	1.56691155
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.56044527
36	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.54631506
37	AR_21909140_ChIP-Seq_LNCAP_Human	1.53703248
38	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.50818371
39	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.50671047
40	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.49263237
41	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.48476848
42	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.46394143
43	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.46079309
44	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.45803902
45	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.45275395
46	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.45075383
47	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.41639002
48	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.41181894
49	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.39711415
50	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.38643723
51	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.37750458
52	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.37597080
53	MYC_22102868_ChIP-Seq_BL_Human	1.36500769
54	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.35711333
55	ELK1_19687146_ChIP-ChIP_HELA_Human	1.35358582
56	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.34428189
57	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.32844120
58	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.32164685
59	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.29853835
60	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.29642383
61	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.27126491
62	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.25554385
63	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.24484196
64	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.22721732
65	RACK7_27058665_Chip-Seq_MCF-7_Human	1.22071651
66	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.20139835
67	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.19428955
68	GABP_19822575_ChIP-Seq_HepG2_Human	1.18556479
69	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.17961270
70	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.17526330
71	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.17320594
72	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.15950018
73	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.15085523
74	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.14920969
75	CHD1_26751641_Chip-Seq_LNCaP_Human	1.14550698
76	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.13874746
77	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.13599745
78	FOXP3_21729870_ChIP-Seq_TREG_Human	1.12513364
79	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.12458095
80	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.11858971
81	GATA1_22025678_ChIP-Seq_K562_Human	1.11806990
82	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.11511949
83	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.06844244
84	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.04654181
85	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.03738411
86	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.03247773
87	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.02812137
88	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.02787452
89	NANOG_21062744_ChIP-ChIP_HESCs_Human	1.01978710
90	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.01740918
91	CIITA_25753668_ChIP-Seq_RAJI_Human	1.00013027
92	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.98671413
93	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.98330924
94	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.98028808
95	RBPJ_21746931_ChIP-Seq_IB4_Human	0.97554823
96	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.96920593
97	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.96722728
98	VDR_23849224_ChIP-Seq_CD4+_Human	0.96112653
99	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.94522779
100	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	0.94357241

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	8.72028032
2	MP0003136_yellow_coat_color	5.86077973
3	MP0005408_hypopigmentation	3.56647842
4	MP0000003_abnormal_adipose_tissue	3.34459230
5	MP0002877_abnormal_melanocyte_morpholog	2.96690399
6	MP0005645_abnormal_hypothalamus_physiol	2.75778704
7	MP0000371_diluted_coat_color	2.46547591
8	MP0010094_abnormal_chromosome_stability	2.40843420
9	MP0002075_abnormal_coat/hair_pigmentati	2.33609463
10	MP0000372_irregular_coat_pigmentation	2.32803053
11	MP0005174_abnormal_tail_pigmentation	2.31482592
12	MP0002009_preneoplasia	2.28091832
13	MP0004957_abnormal_blastocyst_morpholog	2.23896104
14	MP0000013_abnormal_adipose_tissue	2.23588688
15	MP0001348_abnormal_lacrimal_gland	2.22691075
16	MP0005058_abnormal_lysosome_morphology	2.05599924
17	MP0004233_abnormal_muscle_weight	2.04014709
18	MP0003111_abnormal_nucleus_morphology	1.98473485
19	MP0001186_pigmentation_phenotype	1.96450822
20	MP0003077_abnormal_cell_cycle	1.93852553
21	MP0001661_extended_life_span	1.92548880
22	MP0004381_abnormal_hair_follicle	1.88768929
23	MP0003959_abnormal_lean_body	1.70763495
24	MP0008932_abnormal_embryonic_tissue	1.69757914
25	MP0008057_abnormal_DNA_replication	1.66821452
26	MP0009697_abnormal_copulation	1.62341233
27	MP0008058_abnormal_DNA_repair	1.62267334
28	MP0002095_abnormal_skin_pigmentation	1.55796676
29	MP0003693_abnormal_embryo_hatching	1.53621920
30	MP0008438_abnormal_cutaneous_collagen	1.53004563
31	MP0002396_abnormal_hematopoietic_system	1.52866840
32	MP0005076_abnormal_cell_differentiation	1.50264852
33	MP0005197_abnormal_uvea_morphology	1.49761523
34	MP0003186_abnormal_redox_activity	1.47175155
35	MP0001764_abnormal_homeostasis	1.45483569
36	MP0008007_abnormal_cellular_replicative	1.43844122
37	MP0005257_abnormal_intraocular_pressure	1.38116775
38	MP0002938_white_spotting	1.34933696
39	MP0001324_abnormal_eye_pigmentation	1.32047737
40	MP0005375_adipose_tissue_phenotype	1.29536633
41	MP0005451_abnormal_body_composition	1.28662096
42	MP0010307_abnormal_tumor_latency	1.24756800
43	MP0005623_abnormal_meninges_morphology	1.23480329
44	MP0003786_premature_aging	1.22270446
45	MP0009840_abnormal_foam_cell	1.21891067
46	MP0000350_abnormal_cell_proliferation	1.16083672
47	MP0000358_abnormal_cell_content/	1.13286659
48	MP0002697_abnormal_eye_size	1.10887605
49	MP0009672_abnormal_birth_weight	1.05319971
50	MP0009333_abnormal_splenocyte_physiolog	1.02398597
51	MP0002971_abnormal_brown_adipose	0.99968810
52	MP0006035_abnormal_mitochondrial_morpho	0.99419400
53	MP0002139_abnormal_hepatobiliary_system	0.96811093
54	MP0000569_abnormal_digit_pigmentation	0.95540969
55	MP0005075_abnormal_melanosome_morpholog	0.94714579
56	MP0003984_embryonic_growth_retardation	0.94178818
57	MP0005380_embryogenesis_phenotype	0.92109618
58	MP0001672_abnormal_embryogenesis/_devel	0.92109618
59	MP0004808_abnormal_hematopoietic_stem	0.91671804
60	MP0000015_abnormal_ear_pigmentation	0.91091693
61	MP0002088_abnormal_embryonic_growth/wei	0.90082208
62	MP0002166_altered_tumor_susceptibility	0.88467675
63	MP0004272_abnormal_basement_membrane	0.87745574
64	MP0010352_gastrointestinal_tract_polyps	0.87701660
65	MP0003705_abnormal_hypodermis_morpholog	0.85567762
66	MP0005365_abnormal_bile_salt	0.85495751
67	MP0002080_prenatal_lethality	0.85169924
68	MP0002269_muscular_atrophy	0.83603004
69	MP0010030_abnormal_orbit_morphology	0.82369269
70	MP0001697_abnormal_embryo_size	0.81112676
71	MP0003221_abnormal_cardiomyocyte_apopto	0.80586434
72	MP0005330_cardiomyopathy	0.80571629
73	MP0003566_abnormal_cell_adhesion	0.80074638
74	MP0002970_abnormal_white_adipose	0.74129608
75	MP0010234_abnormal_vibrissa_follicle	0.73558188
76	MP0001730_embryonic_growth_arrest	0.72848343
77	MP0000609_abnormal_liver_physiology	0.72176456
78	MP0002086_abnormal_extraembryonic_tissu	0.72157542
79	MP0003879_abnormal_hair_cell	0.71823216
80	MP0000313_abnormal_cell_death	0.71786330
81	MP0001243_abnormal_dermal_layer	0.68797757
82	MP0005332_abnormal_amino_acid	0.67840504
83	MP0005384_cellular_phenotype	0.66527222
84	MP0005621_abnormal_cell_physiology	0.66374850
85	MP0004084_abnormal_cardiac_muscle	0.64864567
86	MP0005584_abnormal_enzyme/coenzyme_acti	0.64854521
87	MP0003634_abnormal_glial_cell	0.64792070
88	MP0000367_abnormal_coat/_hair	0.64122271
89	MP0008775_abnormal_heart_ventricle	0.63284049
90	MP0008260_abnormal_autophagy	0.61694506
91	MP0002896_abnormal_bone_mineralization	0.60735687
92	MP0000747_muscle_weakness	0.60611817
93	MP0000733_abnormal_muscle_development	0.60310030
94	MP0005334_abnormal_fat_pad	0.58881925
95	MP0000759_abnormal_skeletal_muscle	0.58219520
96	MP0003868_abnormal_feces_composition	0.58059893
97	MP0005085_abnormal_gallbladder_physiolo	0.57925860
98	MP0005409_darkened_coat_color	0.57834142
99	MP0002084_abnormal_developmental_patter	0.56375104
100	MP0003453_abnormal_keratinocyte_physiol	0.55474906

Predicted human phenotypes

Rank	Gene Set	Z-score
1	White forelock (HP:0002211)	6.65521075
2	Patchy hypopigmentation of hair (HP:0011365)	6.45705088
3	Down-sloping shoulders (HP:0200021)	4.96902735
4	Cerebellar dysplasia (HP:0007033)	4.35122658
5	Deformed sella turcica (HP:0002681)	4.34650430
6	Spastic paraparesis (HP:0002313)	4.30368484
7	Vertebral compression fractures (HP:0002953)	4.10307325
8	Calcaneovalgus deformity (HP:0001848)	4.04134992
9	Blue irides (HP:0000635)	3.94824235
10	Abnormal auditory evoked potentials (HP:0006958)	3.93379595
11	Neoplasm of the heart (HP:0100544)	3.92143809
12	Submucous cleft hard palate (HP:0000176)	3.61367093
13	Deformed tarsal bones (HP:0008119)	3.48557000
14	Retinal atrophy (HP:0001105)	3.28750938
15	Elbow flexion contracture (HP:0002987)	3.21741879
16	Short 4th metacarpal (HP:0010044)	3.17669399
17	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	3.17669399
18	Overlapping toe (HP:0001845)	3.15352401
19	Heterochromia iridis (HP:0001100)	3.13373628
20	Premature graying of hair (HP:0002216)	3.12534592
21	Abnormal autonomic nervous system physiology (HP:0012332)	3.06734788
22	Hypopigmentation of the fundus (HP:0007894)	3.06187003
23	Neoplasm of the oral cavity (HP:0100649)	3.06069455
24	Paraparesis (HP:0002385)	3.05140948
25	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.99113198
26	Medulloblastoma (HP:0002885)	2.97952194
27	Abnormality of the sella turcica (HP:0002679)	2.92435753
28	Osteolytic defects of the hand bones (HP:0009699)	2.91919097
29	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.91919097
30	Ragged-red muscle fibers (HP:0003200)	2.82185082
31	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.74623300
32	Abnormality of the calcaneus (HP:0008364)	2.73760918
33	Spinal cord lesions (HP:0100561)	2.70998849
34	Syringomyelia (HP:0003396)	2.70998849
35	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.67994596
36	Premature rupture of membranes (HP:0001788)	2.66273377
37	Abnormality of the parietal bone (HP:0002696)	2.66266075
38	Esophageal neoplasm (HP:0100751)	2.60427641
39	Neoplasm of head and neck (HP:0012288)	2.60427641
40	Abnormality of the 4th metacarpal (HP:0010012)	2.59205981
41	Abnormality of the distal phalanges of the toes (HP:0010182)	2.59054430
42	Supernumerary ribs (HP:0005815)	2.57104709
43	Progressive muscle weakness (HP:0003323)	2.55084016
44	Abnormal ossification of hand bones (HP:0005921)	2.48448094
45	Short nail (HP:0001799)	2.47102729
46	Cerebral edema (HP:0002181)	2.35734677
47	Supernumerary bones of the axial skeleton (HP:0009144)	2.30193741
48	Short phalanx of the thumb (HP:0009660)	2.29756917
49	Neoplasm of striated muscle (HP:0009728)	2.27008190
50	Hyperammonemia (HP:0001987)	2.23723414
51	Abnormality of cells of the erythroid lineage (HP:0012130)	2.22494012
52	Albinism (HP:0001022)	2.21403106
53	Hypokinesia (HP:0002375)	2.20238223
54	Hypoplasia of the iris (HP:0007676)	2.18526430
55	Dysmetric saccades (HP:0000641)	2.17240945
56	Thoracolumbar scoliosis (HP:0002944)	2.17167864
57	Fatigue (HP:0012378)	2.16088178
58	Wormian bones (HP:0002645)	2.14521366
59	Abnormal hand bone ossification (HP:0010660)	2.12686820
60	Reticulocytopenia (HP:0001896)	2.10742984
61	Abnormality of the distal phalanx of the thumb (HP:0009617)	2.08319803
62	Cerebral aneurysm (HP:0004944)	2.08299275
63	Large for gestational age (HP:0001520)	2.06679566
64	Cutaneous melanoma (HP:0012056)	2.05290898
65	Chin dimple (HP:0010751)	2.04752725
66	Hypobetalipoproteinemia (HP:0003563)	2.04620149
67	Microvesicular hepatic steatosis (HP:0001414)	2.03236025
68	Macrocytic anemia (HP:0001972)	2.01808530
69	Asymmetry of the thorax (HP:0001555)	2.01511913
70	Abnormal cartilage morphology (HP:0002763)	2.01347086
71	Achilles tendon contracture (HP:0001771)	2.01107557
72	Adducted thumb (HP:0001181)	2.00989290
73	Mitral stenosis (HP:0001718)	1.96487544
74	Intestinal polyp (HP:0005266)	1.95894223
75	Ulnar bowing (HP:0003031)	1.89798836
76	Abnormality of the Achilles tendon (HP:0005109)	1.89759141
77	Ocular albinism (HP:0001107)	1.89048171
78	Cerebral hypomyelination (HP:0006808)	1.88321076
79	Abnormality of pain sensation (HP:0010832)	1.87166821
80	Impaired pain sensation (HP:0007328)	1.87166821
81	Protrusio acetabuli (HP:0003179)	1.82695415
82	Abnormality of methionine metabolism (HP:0010901)	1.81602733
83	Amblyopia (HP:0000646)	1.81041187
84	Biconcave vertebral bodies (HP:0004586)	1.80930776
85	Hemivertebrae (HP:0002937)	1.80421994
86	Knee flexion contracture (HP:0006380)	1.80206780
87	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.78172920
88	Alkalosis (HP:0001948)	1.77910309
89	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.77058946
90	Abnormality of the umbilical cord (HP:0010881)	1.77020483
91	Relative macrocephaly (HP:0004482)	1.75516095
92	Abnormality of dentin (HP:0010299)	1.75203402
93	Pallor (HP:0000980)	1.74908230
94	Abnormality of glycolysis (HP:0004366)	1.74737106
95	Entropion (HP:0000621)	1.74002969
96	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.69471319
97	Synophrys (HP:0000664)	1.68694048
98	Trismus (HP:0000211)	1.68313070
99	Nuclear cataract (HP:0100018)	1.66883472
100	Abnormality of the periventricular white matter (HP:0002518)	1.65872460

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	7.07292604
2	MST1R	4.25034511
3	PBK	4.00440192
4	ICK	3.10945230
5	NME2	2.80301860
6	EEF2K	2.69384987
7	MET	2.63969369
8	ERN1	2.57082443
9	SCYL2	2.51822770
10	DDR2	2.45813391
11	NEK1	2.28870581
12	PAK4	2.14999858
13	CDK3	2.05025329
14	CDK12	1.90722200
15	EIF2AK1	1.67883388
16	TRIB3	1.59594264
17	PRPF4B	1.58567851
18	RPS6KB2	1.53061289
19	LATS2	1.52998494
20	PIK3CG	1.52947653
21	CDC7	1.46935587
22	TTK	1.39194527
23	PRKD3	1.35921656
24	NEK6	1.32703737
25	TGFBR2	1.31725306
26	MARK3	1.24759841
27	BRD4	1.19989738
28	CDK4	1.16757418
29	CDK6	1.16593047
30	IRAK3	1.16367434
31	CHEK2	1.16152464
32	SRPK1	1.12074302
33	EIF2AK3	1.11066905
34	MAPK11	1.06967262
35	RIPK1	1.00795909
36	TAOK3	0.98967058
37	BUB1	0.97157553
38	CCNB1	0.96879601
39	AKT2	0.90605576
40	ERBB4	0.90202839
41	STK16	0.88275976
42	CHEK1	0.85876415
43	BRSK1	0.85862434
44	AURKB	0.85067769
45	TSSK6	0.84578145
46	PDPK1	0.81071880
47	WEE1	0.78555372
48	FLT3	0.78165691
49	MTOR	0.77362184
50	TTN	0.77152366
51	MAP3K6	0.76266275
52	CDK8	0.75403993
53	ATR	0.73333968
54	CDK7	0.69963409
55	BRSK2	0.68605194
56	NTRK1	0.64512897
57	BRAF	0.62401148
58	MAPK12	0.61842485
59	NEK2	0.61420365
60	PDGFRA	0.59513661
61	PKN2	0.59442125
62	JAK3	0.58575955
63	LRRK2	0.55278255
64	BMX	0.54444547
65	AURKA	0.54299636
66	MAPK7	0.53636210
67	CDK1	0.53298397
68	CDK2	0.52406758
69	SMG1	0.50361694
70	PIM1	0.50316933
71	MARK2	0.50096082
72	CDK11A	0.49531865
73	GSK3A	0.48082372
74	PDK1	0.47910385
75	MAP2K2	0.45541657
76	CDK15	0.45379857
77	KSR2	0.44717366
78	CSNK2A2	0.44512446
79	LMTK2	0.43549761
80	ATM	0.42906729
81	LATS1	0.42319563
82	MAP3K8	0.41438188
83	CDK18	0.40854236
84	PLK1	0.40799881
85	SIK1	0.39875693
86	MAPK4	0.38492700
87	SIK3	0.37226470
88	ALK	0.35474746
89	CDK9	0.33906843
90	MELK	0.33578876
91	CDK14	0.33420421
92	MAPKAPK3	0.32927056
93	NEK9	0.32772901
94	MAPK3	0.32733452
95	MAPK14	0.32264751
96	PAK1	0.31947865
97	MAPK10	0.31711544
98	CSNK1E	0.30851781
99	STK4	0.30633214
100	PRKDC	0.30030259

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.72864400
2	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.47166940
3	Arginine biosynthesis_Homo sapiens_hsa00220	3.28887319
4	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.89453963
5	Ribosome_Homo sapiens_hsa03010	2.89317146
6	Tyrosine metabolism_Homo sapiens_hsa00350	2.87310858
7	DNA replication_Homo sapiens_hsa03030	2.86536356
8	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	2.76463821
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.42999195
10	Carbon metabolism_Homo sapiens_hsa01200	2.31194243
11	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	2.26752260
12	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.25068885
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.10167838
14	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.00318031
15	Mismatch repair_Homo sapiens_hsa03430	2.00123815
16	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.99216202
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.93336174
18	One carbon pool by folate_Homo sapiens_hsa00670	1.85113361
19	Phenylalanine metabolism_Homo sapiens_hsa00360	1.79394123
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.74841497
21	Pentose phosphate pathway_Homo sapiens_hsa00030	1.68884928
22	Pyruvate metabolism_Homo sapiens_hsa00620	1.67079598
23	RNA transport_Homo sapiens_hsa03013	1.52685215
24	Spliceosome_Homo sapiens_hsa03040	1.47508297
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.46514162
26	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.40481833
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.37534411
28	Protein export_Homo sapiens_hsa03060	1.35410523
29	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.33016310
30	Galactose metabolism_Homo sapiens_hsa00052	1.28458014
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.25326510
32	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.24372140
33	Sulfur relay system_Homo sapiens_hsa04122	1.23951338
34	Base excision repair_Homo sapiens_hsa03410	1.20256636
35	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.19666095
36	Other glycan degradation_Homo sapiens_hsa00511	1.16260876
37	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.15860535
38	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.14782232
39	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.11855296
40	Cell cycle_Homo sapiens_hsa04110	1.11646625
41	Prion diseases_Homo sapiens_hsa05020	1.08954936
42	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.04734530
43	Complement and coagulation cascades_Homo sapiens_hsa04610	1.04193413
44	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.02720628
45	Viral carcinogenesis_Homo sapiens_hsa05203	0.96009482
46	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95414712
47	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.92950183
48	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.92125504
49	Small cell lung cancer_Homo sapiens_hsa05222	0.90714116
50	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.85422318
51	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.85054952
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.84221082
53	Purine metabolism_Homo sapiens_hsa00230	0.82378770
54	Fanconi anemia pathway_Homo sapiens_hsa03460	0.78207726
55	Lysine degradation_Homo sapiens_hsa00310	0.74933061
56	Sulfur metabolism_Homo sapiens_hsa00920	0.74405952
57	RNA polymerase_Homo sapiens_hsa03020	0.73489327
58	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.73086983
59	Alcoholism_Homo sapiens_hsa05034	0.68157848
60	mRNA surveillance pathway_Homo sapiens_hsa03015	0.65008418
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64985504
62	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.63485008
63	Fatty acid degradation_Homo sapiens_hsa00071	0.61755681
64	Folate biosynthesis_Homo sapiens_hsa00790	0.59011837
65	ABC transporters_Homo sapiens_hsa02010	0.57081600
66	Propanoate metabolism_Homo sapiens_hsa00640	0.56261535
67	Arginine and proline metabolism_Homo sapiens_hsa00330	0.55550817
68	Lysosome_Homo sapiens_hsa04142	0.53996841
69	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.53261178
70	Thyroid cancer_Homo sapiens_hsa05216	0.51835760
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51470110
72	Metabolic pathways_Homo sapiens_hsa01100	0.49946366
73	Melanoma_Homo sapiens_hsa05218	0.47672030
74	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.45644488
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.44661460
76	Non-small cell lung cancer_Homo sapiens_hsa05223	0.43646579
77	Homologous recombination_Homo sapiens_hsa03440	0.42178227
78	Alzheimers disease_Homo sapiens_hsa05010	0.41175053
79	Bile secretion_Homo sapiens_hsa04976	0.38503273
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.38470203
81	Melanogenesis_Homo sapiens_hsa04916	0.38184200
82	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.35732905
83	Proteasome_Homo sapiens_hsa03050	0.35453320
84	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.35137674
85	Parkinsons disease_Homo sapiens_hsa05012	0.34587975
86	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.34111800
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.33832125
88	Vibrio cholerae infection_Homo sapiens_hsa05110	0.32059398
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.29917432
90	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.29067888
91	Glutathione metabolism_Homo sapiens_hsa00480	0.28482925
92	MicroRNAs in cancer_Homo sapiens_hsa05206	0.28432012
93	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.27870229
94	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.23635775
95	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.23267369
96	Fatty acid metabolism_Homo sapiens_hsa01212	0.23260694
97	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.21717660
98	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.19983700
99	Renal cell carcinoma_Homo sapiens_hsa05211	0.19901913
100	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.19384905

GAGE12D

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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