ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	blastocyst development (GO:0001824)	7.09699293
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.58533069
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.57747052
4	ATP synthesis coupled proton transport (GO:0015986)	6.57747052
5	oxidative phosphorylation (GO:0006119)	6.18653300
6	proteasome assembly (GO:0043248)	6.18167830
7	cornea development in camera-type eye (GO:0061303)	6.10774998
8	regulation of gene expression by genetic imprinting (GO:0006349)	5.84732827
9	maturation of SSU-rRNA (GO:0030490)	5.82442422
10	rRNA modification (GO:0000154)	5.47919713
11	ribosomal small subunit biogenesis (GO:0042274)	5.45300417
12	diterpenoid biosynthetic process (GO:0016102)	5.41920578
13	positive regulation of odontogenesis (GO:0042482)	4.98745213
14	terpenoid biosynthetic process (GO:0016114)	4.97343527
15	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.83455953
16	respiratory electron transport chain (GO:0022904)	4.83295830
17	nephron tubule formation (GO:0072079)	4.83214913
18	omega-hydroxylase P450 pathway (GO:0097267)	4.78450773
19	ribosomal large subunit biogenesis (GO:0042273)	4.77821006
20	electron transport chain (GO:0022900)	4.73636335
21	regulation of cellular respiration (GO:0043457)	4.73580369
22	chaperone-mediated protein transport (GO:0072321)	4.69791217
23	rRNA methylation (GO:0031167)	4.64308621
24	transcription from mitochondrial promoter (GO:0006390)	4.48949403
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.45068739
26	formation of translation preinitiation complex (GO:0001731)	4.44652838
27	ATP biosynthetic process (GO:0006754)	4.29627914
28	viral transcription (GO:0019083)	4.16991584
29	cytochrome complex assembly (GO:0017004)	4.15425157
30	aerobic respiration (GO:0009060)	4.11962946
31	respiratory chain complex IV assembly (GO:0008535)	4.11688482
32	hepatocyte differentiation (GO:0070365)	4.07909858
33	phenylpropanoid metabolic process (GO:0009698)	4.02710541
34	translational termination (GO:0006415)	4.00550274
35	genetic imprinting (GO:0071514)	3.97324269
36	myeloid cell homeostasis (GO:0002262)	3.91835599
37	translation (GO:0006412)	3.91542894
38	translational initiation (GO:0006413)	3.91519980
39	protein targeting to mitochondrion (GO:0006626)	3.89156265
40	peptidyl-histidine modification (GO:0018202)	3.87638888
41	protein-cofactor linkage (GO:0018065)	3.87515023
42	mitochondrial RNA metabolic process (GO:0000959)	3.81416385
43	ribonucleoprotein complex disassembly (GO:0032988)	3.76609981
44	flavonoid metabolic process (GO:0009812)	3.75953865
45	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.75120443
46	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.74644123
47	translational elongation (GO:0006414)	3.74540199
48	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.73115728
49	ribonucleoprotein complex biogenesis (GO:0022613)	3.71402948
50	cotranslational protein targeting to membrane (GO:0006613)	3.66564141
51	protein targeting to ER (GO:0045047)	3.60477115
52	establishment of protein localization to mitochondrion (GO:0072655)	3.58523988
53	epoxygenase P450 pathway (GO:0019373)	3.58145564
54	maturation of 5.8S rRNA (GO:0000460)	3.57781252
55	N-terminal protein amino acid acetylation (GO:0006474)	3.56301500
56	protein localization to endoplasmic reticulum (GO:0070972)	3.53145462
57	protein localization to mitochondrion (GO:0070585)	3.51603541
58	xenobiotic catabolic process (GO:0042178)	3.50375194
59	regulation of mitochondrial translation (GO:0070129)	3.49547473
60	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.46748533
61	rRNA processing (GO:0006364)	3.45806206
62	hydrogen peroxide biosynthetic process (GO:0050665)	3.44659496
63	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.42472192
64	hydrogen ion transmembrane transport (GO:1902600)	3.42383976
65	protein complex biogenesis (GO:0070271)	3.41579065
66	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.40483012
67	histone exchange (GO:0043486)	3.39286889
68	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.37521639
69	pseudouridine synthesis (GO:0001522)	3.37424942
70	male meiosis I (GO:0007141)	3.36569695
71	cellular component biogenesis (GO:0044085)	3.36543646
72	CENP-A containing nucleosome assembly (GO:0034080)	3.35981242
73	mitochondrial respiratory chain complex assembly (GO:0033108)	3.35665497
74	mitochondrial transport (GO:0006839)	3.32551453
75	protein K6-linked ubiquitination (GO:0085020)	3.32136445
76	cellular respiration (GO:0045333)	3.30021913
77	removal of superoxide radicals (GO:0019430)	3.29253640
78	cellular response to superoxide (GO:0071451)	3.29253640
79	cellular response to oxygen radical (GO:0071450)	3.29253640
80	rRNA metabolic process (GO:0016072)	3.29068466
81	nucleoside triphosphate biosynthetic process (GO:0009142)	3.27772375
82	DNA replication checkpoint (GO:0000076)	3.27659220
83	DNA unwinding involved in DNA replication (GO:0006268)	3.26532981
84	resolution of meiotic recombination intermediates (GO:0000712)	3.24522459
85	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.20623050
86	meiosis I (GO:0007127)	3.19907976
87	purine nucleoside monophosphate biosynthetic process (GO:0009127)	3.18567964
88	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	3.18567964
89	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.17679122
90	regulation of meiosis I (GO:0060631)	3.17416727
91	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.15373282
92	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.14177270
93	termination of RNA polymerase III transcription (GO:0006386)	3.14177270
94	ribosome assembly (GO:0042255)	3.13233237
95	chromatin remodeling at centromere (GO:0031055)	3.12584439
96	vitamin D metabolic process (GO:0042359)	3.12515326
97	proton transport (GO:0015992)	3.09135492
98	synaptonemal complex assembly (GO:0007130)	3.08346217
99	ventricular cardiac muscle cell development (GO:0055015)	3.05800263
100	reactive oxygen species biosynthetic process (GO:1903409)	3.04427686

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.80339214
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.67329439
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.23641309
4	E2F7_22180533_ChIP-Seq_HELA_Human	4.04401442
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.87779328
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.82497471
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.80902888
8	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.69954743
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.42989655
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.38225415
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.32956367
12	MYC_18358816_ChIP-ChIP_MESCs_Mouse	3.23317052
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.06899609
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.91606161
15	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.91242192
16	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.86743132
17	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.81613733
18	DCP1A_22483619_ChIP-Seq_HELA_Human	2.64179025
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.45570327
20	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.43622808
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.37390973
22	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.28460995
23	VDR_23849224_ChIP-Seq_CD4+_Human	2.25923537
24	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.25383769
25	FOXP3_21729870_ChIP-Seq_TREG_Human	2.16851474
26	TTF2_22483619_ChIP-Seq_HELA_Human	2.14031184
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.06970533
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.06787922
29	XRN2_22483619_ChIP-Seq_HELA_Human	2.03260291
30	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.99031628
31	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.90142856
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.84447219
33	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.84043206
34	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.83733282
35	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.83223102
36	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.81529646
37	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.81411586
38	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.81204785
39	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.73903379
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.69998147
41	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.67403659
42	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.67236551
43	ELK1_19687146_ChIP-ChIP_HELA_Human	1.64035863
44	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.63901104
45	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.56766303
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.53479873
47	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.46610201
48	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46568221
49	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.42806188
50	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.42286839
51	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.39337787
52	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.38265160
53	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.38111503
54	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.38015227
55	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.37081126
56	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.35319263
57	ZNF263_19887448_ChIP-Seq_K562_Human	1.35121390
58	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.27376704
59	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27128973
60	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.23161834
61	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.21478411
62	AR_21909140_ChIP-Seq_LNCAP_Human	1.19496889
63	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.17385557
64	KDM5A_27292631_Chip-Seq_BREAST_Human	1.15183405
65	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.12625097
66	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.10212305
67	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.08436077
68	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.06028721
69	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.04914015
70	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.04109785
71	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	1.03572834
72	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.02368368
73	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.01591438
74	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.99881770
75	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.99423679
76	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.97363509
77	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.96385574
78	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.91225420
79	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.90740650
80	E2F1_20622854_ChIP-Seq_HELA_Human	0.88860124
81	TFEB_21752829_ChIP-Seq_HELA_Human	0.88564320
82	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.88456375
83	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.87947726
84	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.87685028
85	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.86985021
86	HTT_18923047_ChIP-ChIP_STHdh_Human	0.86472520
87	MYC_18940864_ChIP-ChIP_HL60_Human	0.86058191
88	NANOG_18692474_ChIP-Seq_MEFs_Mouse	0.86033637
89	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.85238020
90	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.84676418
91	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.84621015
92	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.82548389
93	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.82378091
94	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.82048788
95	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.81522710
96	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.80390809
97	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.80068392
98	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.77360171
99	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.76984723
100	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.75285284

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	4.99478288
2	MP0008875_abnormal_xenobiotic_pharmacok	4.18722585
3	MP0008872_abnormal_physiological_respon	3.64598084
4	MP0010030_abnormal_orbit_morphology	3.61086331
5	MP0004957_abnormal_blastocyst_morpholog	3.55678313
6	MP0008260_abnormal_autophagy	3.55582844
7	MP0003186_abnormal_redox_activity	3.35703505
8	MP0005670_abnormal_white_adipose	3.21233677
9	MP0006036_abnormal_mitochondrial_physio	3.15452411
10	MP0008057_abnormal_DNA_replication	2.95029588
11	MP0003786_premature_aging	2.29377856
12	MP0005636_abnormal_mineral_homeostasis	2.29124593
13	MP0010094_abnormal_chromosome_stability	2.28525101
14	MP0008058_abnormal_DNA_repair	2.23133570
15	MP0003718_maternal_effect	2.18090596
16	MP0003077_abnormal_cell_cycle	2.00399928
17	MP0003646_muscle_fatigue	1.87390136
18	MP0001764_abnormal_homeostasis	1.86177652
19	MP0009697_abnormal_copulation	1.75219874
20	MP0002139_abnormal_hepatobiliary_system	1.75202774
21	MP0008995_early_reproductive_senescence	1.74353985
22	MP0003693_abnormal_embryo_hatching	1.68433085
23	MP0002210_abnormal_sex_determination	1.66980838
24	MP0005319_abnormal_enzyme/_coenzyme	1.65003288
25	MP0006035_abnormal_mitochondrial_morpho	1.63772908
26	MP0005058_abnormal_lysosome_morphology	1.59982605
27	MP0010234_abnormal_vibrissa_follicle	1.58740073
28	MP0009333_abnormal_splenocyte_physiolog	1.55976632
29	MP0003567_abnormal_fetal_cardiomyocyte	1.54777502
30	MP0003111_abnormal_nucleus_morphology	1.53551552
31	MP0001929_abnormal_gametogenesis	1.52783704
32	MP0005085_abnormal_gallbladder_physiolo	1.49352574
33	MP0002735_abnormal_chemical_nociception	1.48233680
34	MP0000358_abnormal_cell_content/	1.47458806
35	MP0005360_urolithiasis	1.40908361
36	MP0005410_abnormal_fertilization	1.40354992
37	MP0005332_abnormal_amino_acid	1.38237834
38	MP0009379_abnormal_foot_pigmentation	1.38220397
39	MP0005451_abnormal_body_composition	1.33168288
40	MP0003698_abnormal_male_reproductive	1.32304969
41	MP0004215_abnormal_myocardial_fiber	1.27834805
42	MP0005389_reproductive_system_phenotype	1.27158197
43	MP0006138_congestive_heart_failure	1.26729460
44	MP0002160_abnormal_reproductive_system	1.26173431
45	MP0001661_extended_life_span	1.23749090
46	MP0008789_abnormal_olfactory_epithelium	1.23161167
47	MP0009764_decreased_sensitivity_to	1.20498721
48	MP0000490_abnormal_crypts_of	1.19688987
49	MP0001145_abnormal_male_reproductive	1.18620356
50	MP0000015_abnormal_ear_pigmentation	1.18309324
51	MP0002796_impaired_skin_barrier	1.17648012
52	MP0002837_dystrophic_cardiac_calcinosis	1.14919361
53	MP0001919_abnormal_reproductive_system	1.14774273
54	MP0008932_abnormal_embryonic_tissue	1.14356026
55	MP0006292_abnormal_olfactory_placode	1.14131490
56	MP0000653_abnormal_sex_gland	1.13544824
57	MP0001730_embryonic_growth_arrest	1.09056764
58	MP0008874_decreased_physiological_sensi	1.05968641
59	MP0000372_irregular_coat_pigmentation	1.00550916
60	MP0006072_abnormal_retinal_apoptosis	0.98870119
61	MP0000350_abnormal_cell_proliferation	0.97891057
62	MP0005266_abnormal_metabolism	0.95988835
63	MP0001346_abnormal_lacrimal_gland	0.95058925
64	MP0001756_abnormal_urination	0.94275007
65	MP0005171_absent_coat_pigmentation	0.92156792
66	MP0001697_abnormal_embryo_size	0.90788087
67	MP0002080_prenatal_lethality	0.90697959
68	MP0008873_increased_physiological_sensi	0.88300799
69	MP0001986_abnormal_taste_sensitivity	0.87217497
70	MP0003699_abnormal_female_reproductive	0.85053904
71	MP0005365_abnormal_bile_salt	0.83849957
72	MP0000313_abnormal_cell_death	0.83351202
73	MP0002909_abnormal_adrenal_gland	0.82745979
74	MP0005380_embryogenesis_phenotype	0.81365131
75	MP0001672_abnormal_embryogenesis/_devel	0.81365131
76	MP0003878_abnormal_ear_physiology	0.78180597
77	MP0005377_hearing/vestibular/ear_phenot	0.78180597
78	MP0005330_cardiomyopathy	0.76415418
79	MP0003890_abnormal_embryonic-extraembry	0.75518136
80	MP0005501_abnormal_skin_physiology	0.75378554
81	MP0005257_abnormal_intraocular_pressure	0.75276283
82	MP0002161_abnormal_fertility/fecundity	0.74719956
83	MP0005165_increased_susceptibility_to	0.74029947
84	MP0005408_hypopigmentation	0.72087760
85	MP0002938_white_spotting	0.71415920
86	MP0002132_abnormal_respiratory_system	0.71141254
87	MP0001905_abnormal_dopamine_level	0.70435622
88	MP0000639_abnormal_adrenal_gland	0.67763300
89	MP0005499_abnormal_olfactory_system	0.65644453
90	MP0005394_taste/olfaction_phenotype	0.65644453
91	MP0009765_abnormal_xenobiotic_induced	0.64858157
92	MP0005376_homeostasis/metabolism_phenot	0.62330460
93	MP0001529_abnormal_vocalization	0.62225548
94	MP0003984_embryonic_growth_retardation	0.60723686
95	MP0002095_abnormal_skin_pigmentation	0.60132566
96	MP0002088_abnormal_embryonic_growth/wei	0.60113125
97	MP0005551_abnormal_eye_electrophysiolog	0.59513928
98	MP0003137_abnormal_impulse_conducting	0.55431772
99	MP0009046_muscle_twitch	0.51561642
100	MP0000647_abnormal_sebaceous_gland	0.49881855

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	6.92064982
2	Hyperalaninemia (HP:0003348)	6.92064982
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	6.92064982
4	Reticulocytopenia (HP:0001896)	5.74535821
5	Acute necrotizing encephalopathy (HP:0006965)	5.30702527
6	Abnormal mitochondria in muscle tissue (HP:0008316)	4.81337444
7	Increased CSF lactate (HP:0002490)	4.64184162
8	Acute encephalopathy (HP:0006846)	4.43333203
9	Cerebral hypomyelination (HP:0006808)	4.41845055
10	Progressive macrocephaly (HP:0004481)	4.36468290
11	Mitochondrial inheritance (HP:0001427)	4.27103239
12	Respiratory difficulties (HP:0002880)	4.16666760
13	3-Methylglutaconic aciduria (HP:0003535)	3.91160100
14	Increased serum lactate (HP:0002151)	3.70337251
15	Increased hepatocellular lipid droplets (HP:0006565)	3.59404027
16	Cerebral edema (HP:0002181)	3.57058225
17	Lipid accumulation in hepatocytes (HP:0006561)	3.40514795
18	Lactic acidosis (HP:0003128)	3.40176799
19	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.32704033
20	Macrocytic anemia (HP:0001972)	3.26915200
21	Leukodystrophy (HP:0002415)	3.21257502
22	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.17431877
23	Hepatocellular necrosis (HP:0001404)	3.15420361
24	CNS hypomyelination (HP:0003429)	3.12838996
25	Birth length less than 3rd percentile (HP:0003561)	3.12082793
26	Increased intramyocellular lipid droplets (HP:0012240)	3.04027232
27	Premature ovarian failure (HP:0008209)	2.95340820
28	CNS demyelination (HP:0007305)	2.92698619
29	Abnormality of serum amino acid levels (HP:0003112)	2.92041246
30	Renal Fanconi syndrome (HP:0001994)	2.85607307
31	Limb dystonia (HP:0002451)	2.78176563
32	Chromsome breakage (HP:0040012)	2.78084127
33	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.76938553
34	Hypoplasia of the fovea (HP:0007750)	2.76938553
35	Microvesicular hepatic steatosis (HP:0001414)	2.75977499
36	Pallor (HP:0000980)	2.69788694
37	Dysphonia (HP:0001618)	2.67744079
38	Exercise intolerance (HP:0003546)	2.66138261
39	Lethargy (HP:0001254)	2.64827071
40	Hepatic necrosis (HP:0002605)	2.62505479
41	Duplicated collecting system (HP:0000081)	2.62436365
42	Spastic paraparesis (HP:0002313)	2.62288197
43	Increased muscle lipid content (HP:0009058)	2.60923554
44	Abnormality of pyrimidine metabolism (HP:0004353)	2.60868067
45	Respiratory failure (HP:0002878)	2.59790903
46	Progressive muscle weakness (HP:0003323)	2.53694901
47	Abnormality of the fovea (HP:0000493)	2.51903192
48	Hypomagnesemia (HP:0002917)	2.50692202
49	X-linked dominant inheritance (HP:0001423)	2.47072290
50	Pendular nystagmus (HP:0012043)	2.46695740
51	Aplasia/hypoplasia of the uterus (HP:0008684)	2.44656565
52	Abnormality of magnesium homeostasis (HP:0004921)	2.43140366
53	Fused cervical vertebrae (HP:0002949)	2.38974010
54	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.38050800
55	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.38050800
56	Spontaneous abortion (HP:0005268)	2.36985011
57	Poor speech (HP:0002465)	2.36848523
58	Abnormality of the renal collecting system (HP:0004742)	2.35671910
59	Conjugated hyperbilirubinemia (HP:0002908)	2.31595112
60	Abnormal hemoglobin (HP:0011902)	2.31429001
61	Optic disc pallor (HP:0000543)	2.30502118
62	Abnormality of DNA repair (HP:0003254)	2.28529302
63	Hyperglycinemia (HP:0002154)	2.28172704
64	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.27380670
65	Redundant skin (HP:0001582)	2.20944785
66	Delusions (HP:0000746)	2.20758851
67	Breast hypoplasia (HP:0003187)	2.17354277
68	Testicular atrophy (HP:0000029)	2.16928384
69	Abnormality of the ileum (HP:0001549)	2.15727712
70	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.13578124
71	Meckel diverticulum (HP:0002245)	2.13516074
72	Azoospermia (HP:0000027)	2.11765367
73	Microretrognathia (HP:0000308)	2.11287324
74	Abnormal spermatogenesis (HP:0008669)	2.11162248
75	Exertional dyspnea (HP:0002875)	2.10556612
76	Methylmalonic aciduria (HP:0012120)	2.09571810
77	Abnormality of cells of the erythroid lineage (HP:0012130)	2.09512157
78	Hypoplasia of the uterus (HP:0000013)	2.08922341
79	Secondary amenorrhea (HP:0000869)	2.07910346
80	Septate vagina (HP:0001153)	2.07908751
81	Choreoathetosis (HP:0001266)	2.06764541
82	Sensory axonal neuropathy (HP:0003390)	2.05320464
83	Abnormality of lateral ventricle (HP:0030047)	2.03354986
84	Hypergonadotropic hypogonadism (HP:0000815)	2.02158166
85	Neuroendocrine neoplasm (HP:0100634)	2.01655763
86	Abnormality of the preputium (HP:0100587)	2.01554119
87	Ureteral duplication (HP:0000073)	1.97685415
88	Paralysis (HP:0003470)	1.96566553
89	Aplasia/Hypoplasia of the macula (HP:0008059)	1.93519640
90	J-shaped sella turcica (HP:0002680)	1.89656779
91	Sparse eyelashes (HP:0000653)	1.88133313
92	Unsteady gait (HP:0002317)	1.84043965
93	Abnormality of reticulocytes (HP:0004312)	1.80168684
94	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.79672365
95	Conjunctival hamartoma (HP:0100780)	1.78789828
96	Cleft eyelid (HP:0000625)	1.76992431
97	Absent thumb (HP:0009777)	1.76737338
98	Blindness (HP:0000618)	1.76610747
99	Pheochromocytoma (HP:0002666)	1.76361340
100	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.76214542

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	7.32326368
2	NME2	6.56550396
3	PBK	6.55959555
4	NEK1	3.81759390
5	EIF2AK1	3.65016002
6	MST4	3.21583557
7	STK16	3.04083149
8	VRK2	2.60082690
9	TLK1	2.55210448
10	WNK4	2.48583275
11	EIF2AK3	2.37915970
12	STK39	2.21698936
13	OXSR1	2.04939923
14	NUAK1	1.64147900
15	SRPK1	1.60520083
16	MAP3K12	1.39406448
17	STK4	1.27533963
18	BUB1	1.19175396
19	PLK3	1.10233310
20	NEK2	1.06215740
21	BRSK1	1.02764358
22	PINK1	1.02299132
23	ILK	0.83063790
24	LMTK2	0.79826708
25	ABL2	0.79610409
26	EIF2AK2	0.78882929
27	PHKG1	0.76093869
28	PHKG2	0.76093869
29	MKNK1	0.74774447
30	CHEK2	0.73241861
31	CCNB1	0.71709280
32	RPS6KB2	0.68864015
33	MKNK2	0.68392923
34	SCYL2	0.67919814
35	BCKDK	0.62657916
36	CDK19	0.60268965
37	AURKA	0.58206976
38	EEF2K	0.57897380
39	CSNK1G3	0.56166885
40	PLK1	0.55718612
41	PRKCI	0.54389509
42	TRIM28	0.54248252
43	CDK7	0.54127867
44	AURKB	0.52606288
45	BRSK2	0.48709935
46	CSF1R	0.48195224
47	DAPK1	0.48094148
48	TSSK6	0.47673386
49	JAK3	0.47062176
50	VRK1	0.46564594
51	ZAK	0.46286780
52	MARK3	0.45257732
53	CSNK1G2	0.43218579
54	CSNK2A1	0.42760925
55	WEE1	0.42235247
56	BMPR2	0.41679752
57	BMX	0.41583638
58	DAPK3	0.40037744
59	CHEK1	0.39862044
60	DMPK	0.39656812
61	CSNK1A1L	0.39264101
62	ATR	0.38011280
63	MAPKAPK3	0.37573185
64	TTK	0.37431288
65	CSNK1E	0.36428429
66	CSNK2A2	0.36220171
67	GRK1	0.36080665
68	PIK3CG	0.34857979
69	CSNK1G1	0.33686093
70	DYRK2	0.33055627
71	NME1	0.33008634
72	GRK5	0.31742795
73	ADRBK2	0.31651475
74	PAK1	0.31554079
75	MYLK	0.27927796
76	MAP3K1	0.27508406
77	CDC7	0.27184648
78	MUSK	0.25359660
79	PRKG2	0.24630975
80	PKN1	0.24324574
81	PDPK1	0.23903789
82	GRK6	0.21318386
83	NEK6	0.20687134
84	CDK2	0.20220186
85	MAPK4	0.19924971
86	STK10	0.19540564
87	MAP3K5	0.19344290
88	FGR	0.19291982
89	CDK1	0.19208049
90	STK3	0.18617937
91	PRKCA	0.18448997
92	TRPM7	0.17897979
93	MST1R	0.17541377
94	PRKCG	0.17300389
95	INSRR	0.15915748
96	CSNK1A1	0.15320999
97	TAF1	0.15153607
98	AKT2	0.14855065
99	MAP4K2	0.13806253
100	PRKACB	0.11980918

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.04570199
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.48396392
3	Parkinsons disease_Homo sapiens_hsa05012	4.09450449
4	Proteasome_Homo sapiens_hsa03050	3.36407619
5	Huntingtons disease_Homo sapiens_hsa05016	3.14137702
6	Homologous recombination_Homo sapiens_hsa03440	2.96151818
7	DNA replication_Homo sapiens_hsa03030	2.81387515
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.70205225
9	Alzheimers disease_Homo sapiens_hsa05010	2.67840644
10	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.50800435
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.31182413
12	Cardiac muscle contraction_Homo sapiens_hsa04260	2.22068174
13	RNA polymerase_Homo sapiens_hsa03020	2.14051611
14	Basal transcription factors_Homo sapiens_hsa03022	2.10435541
15	Mismatch repair_Homo sapiens_hsa03430	2.08016070
16	Fanconi anemia pathway_Homo sapiens_hsa03460	2.04020395
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.93917936
18	Protein export_Homo sapiens_hsa03060	1.92497901
19	Pyruvate metabolism_Homo sapiens_hsa00620	1.82423315
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.80730371
21	RNA transport_Homo sapiens_hsa03013	1.69759090
22	Spliceosome_Homo sapiens_hsa03040	1.68898742
23	Regulation of autophagy_Homo sapiens_hsa04140	1.51818763
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.51756868
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.45772122
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.44945742
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.36448888
28	One carbon pool by folate_Homo sapiens_hsa00670	1.28464427
29	RNA degradation_Homo sapiens_hsa03018	1.27832799
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.25150201
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.23827297
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.17325622
33	Base excision repair_Homo sapiens_hsa03410	1.16433231
34	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.14712563
35	Carbon metabolism_Homo sapiens_hsa01200	1.09491636
36	Sulfur metabolism_Homo sapiens_hsa00920	1.06833620
37	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.06081691
38	Purine metabolism_Homo sapiens_hsa00230	1.03500582
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.99730393
40	Sulfur relay system_Homo sapiens_hsa04122	0.92737799
41	Pentose phosphate pathway_Homo sapiens_hsa00030	0.89515995
42	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89256701
43	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84329754
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.83388604
45	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.82783796
46	Metabolic pathways_Homo sapiens_hsa01100	0.81885590
47	Retinol metabolism_Homo sapiens_hsa00830	0.79026933
48	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.78353752
49	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.77719975
50	Folate biosynthesis_Homo sapiens_hsa00790	0.77664995
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.74826837
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.69652701
53	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.68535907
54	Fatty acid elongation_Homo sapiens_hsa00062	0.68051671
55	Phototransduction_Homo sapiens_hsa04744	0.66890745
56	Cell cycle_Homo sapiens_hsa04110	0.66250160
57	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.66006852
58	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.62991541
59	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.58876985
60	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.57017571
61	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.56901206
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.53565160
63	Propanoate metabolism_Homo sapiens_hsa00640	0.48715934
64	Tyrosine metabolism_Homo sapiens_hsa00350	0.48500214
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.48122706
66	Asthma_Homo sapiens_hsa05310	0.48015386
67	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.45739655
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.43547683
69	Peroxisome_Homo sapiens_hsa04146	0.41086443
70	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40678779
71	Phenylalanine metabolism_Homo sapiens_hsa00360	0.38270264
72	Galactose metabolism_Homo sapiens_hsa00052	0.38263967
73	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.35459003
74	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.33185539
75	mRNA surveillance pathway_Homo sapiens_hsa03015	0.31643824
76	Oocyte meiosis_Homo sapiens_hsa04114	0.30465464
77	Arginine and proline metabolism_Homo sapiens_hsa00330	0.27467374
78	Steroid biosynthesis_Homo sapiens_hsa00100	0.26451070
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.26426403
80	Ether lipid metabolism_Homo sapiens_hsa00565	0.24283341
81	Basal cell carcinoma_Homo sapiens_hsa05217	0.24153827
82	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.23983381
83	p53 signaling pathway_Homo sapiens_hsa04115	0.23130398
84	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.22928430
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.21978500
86	Nitrogen metabolism_Homo sapiens_hsa00910	0.20067157
87	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.19953843
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.19139900
89	Fatty acid degradation_Homo sapiens_hsa00071	0.19133216
90	Glutathione metabolism_Homo sapiens_hsa00480	0.18525607
91	Arginine biosynthesis_Homo sapiens_hsa00220	0.16800151
92	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.16644242
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.16039903
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.15584101
95	Histidine metabolism_Homo sapiens_hsa00340	0.14104047
96	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.11803283
97	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.09426870
98	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.09417625
99	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.07580618
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.07433529

GAGE12E

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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