ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sexual reproduction (GO:0019953)	9.86143291
2	melanin biosynthetic process (GO:0042438)	8.58891765
3	melanin metabolic process (GO:0006582)	7.73666392
4	secondary metabolite biosynthetic process (GO:0044550)	6.90108456
5	blastocyst development (GO:0001824)	6.77443134
6	tyrosine metabolic process (GO:0006570)	6.00711307
7	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	5.43617410
8	omega-hydroxylase P450 pathway (GO:0097267)	5.31289647
9	regulation of gene expression by genetic imprinting (GO:0006349)	5.24502851
10	N-terminal protein amino acid acetylation (GO:0006474)	4.85377145
11	formation of translation preinitiation complex (GO:0001731)	4.57904492
12	proteasome assembly (GO:0043248)	4.57043551
13	diterpenoid biosynthetic process (GO:0016102)	4.55338527
14	DNA unwinding involved in DNA replication (GO:0006268)	4.24454792
15	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	4.23778601
16	rRNA modification (GO:0000154)	4.19108696
17	myeloid cell homeostasis (GO:0002262)	4.18381062
18	protein maturation by protein folding (GO:0022417)	4.15191726
19	ribosome assembly (GO:0042255)	4.10637913
20	epoxygenase P450 pathway (GO:0019373)	4.00563382
21	developmental pigmentation (GO:0048066)	3.99430822
22	ribosomal large subunit biogenesis (GO:0042273)	3.95180767
23	COPI coating of Golgi vesicle (GO:0048205)	3.88346134
24	Golgi transport vesicle coating (GO:0048200)	3.88346134
25	regulation of cytokine secretion involved in immune response (GO:0002739)	3.87181093
26	peptidyl-proline hydroxylation (GO:0019511)	3.77506094
27	phenylpropanoid metabolic process (GO:0009698)	3.75670764
28	genetic imprinting (GO:0071514)	3.72460757
29	rRNA methylation (GO:0031167)	3.71067311
30	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.69453382
31	ribosome biogenesis (GO:0042254)	3.69102925
32	transcription from mitochondrial promoter (GO:0006390)	3.66263931
33	maturation of 5.8S rRNA (GO:0000460)	3.65403686
34	oxidative phosphorylation (GO:0006119)	3.62357112
35	mitochondrial RNA metabolic process (GO:0000959)	3.61053494
36	aerobic respiration (GO:0009060)	3.59906180
37	ribonucleoprotein complex biogenesis (GO:0022613)	3.55307932
38	tricarboxylic acid cycle (GO:0006099)	3.53457190
39	flavonoid metabolic process (GO:0009812)	3.52188057
40	xenobiotic catabolic process (GO:0042178)	3.50444154
41	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.38358308
42	apoptotic cell clearance (GO:0043277)	3.37995337
43	very-low-density lipoprotein particle assembly (GO:0034379)	3.30230918
44	folic acid metabolic process (GO:0046655)	3.26477337
45	terpenoid biosynthetic process (GO:0016114)	3.22350980
46	aromatic amino acid family metabolic process (GO:0009072)	3.21838294
47	hepatocyte differentiation (GO:0070365)	3.19578372
48	negative regulation of mitochondrion organization (GO:0010823)	3.14918344
49	vitamin D metabolic process (GO:0042359)	3.14127884
50	4-hydroxyproline metabolic process (GO:0019471)	3.13348997
51	synaptonemal complex assembly (GO:0007130)	3.12693926
52	ventricular cardiac muscle cell development (GO:0055015)	3.09004204
53	protein retention in ER lumen (GO:0006621)	3.08486230
54	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.07456572
55	mitotic sister chromatid segregation (GO:0000070)	3.05738425
56	chaperone-mediated protein transport (GO:0072321)	3.04407018
57	ribosomal small subunit biogenesis (GO:0042274)	3.03564350
58	protein targeting to mitochondrion (GO:0006626)	2.99488807
59	translation (GO:0006412)	2.99054296
60	pseudouridine synthesis (GO:0001522)	2.96883439
61	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.95004963
62	hydrogen peroxide biosynthetic process (GO:0050665)	2.92973349
63	mitochondrial fusion (GO:0008053)	2.92339908
64	basement membrane organization (GO:0071711)	2.89581828
65	secondary metabolic process (GO:0019748)	2.89475673
66	enteric nervous system development (GO:0048484)	2.89333361
67	protein targeting to ER (GO:0045047)	2.87398827
68	cotranslational protein targeting to membrane (GO:0006613)	2.87117464
69	protein hydroxylation (GO:0018126)	2.84827686
70	regulation of cellular respiration (GO:0043457)	2.83538312
71	mitotic metaphase plate congression (GO:0007080)	2.83328448
72	tRNA aminoacylation for protein translation (GO:0006418)	2.83043636
73	meiotic chromosome segregation (GO:0045132)	2.82407629
74	protein localization to endoplasmic reticulum (GO:0070972)	2.81485453
75	regulation of mitotic spindle organization (GO:0060236)	2.80392075
76	protein-cofactor linkage (GO:0018065)	2.77973192
77	synaptonemal complex organization (GO:0070193)	2.77288416
78	translational initiation (GO:0006413)	2.77156943
79	response to food (GO:0032094)	2.77078711
80	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.76109357
81	rRNA processing (GO:0006364)	2.75989161
82	pigment biosynthetic process (GO:0046148)	2.75951092
83	vagina development (GO:0060068)	2.75452223
84	GDP-mannose metabolic process (GO:0019673)	2.74271180
85	mitochondrial fission (GO:0000266)	2.74135510
86	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.73922295
87	cellular respiration (GO:0045333)	2.73230502
88	establishment of protein localization to mitochondrion (GO:0072655)	2.72897347
89	response to iron ion (GO:0010039)	2.72204868
90	termination of RNA polymerase III transcription (GO:0006386)	2.71394173
91	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.71394173
92	tRNA aminoacylation (GO:0043039)	2.70685207
93	amino acid activation (GO:0043038)	2.70685207
94	cellular component biogenesis (GO:0044085)	2.70145258
95	amyloid precursor protein catabolic process (GO:0042987)	2.68799929
96	protein N-linked glycosylation via asparagine (GO:0018279)	2.65348202
97	response to arsenic-containing substance (GO:0046685)	2.64539482
98	placenta development (GO:0001890)	2.63771942
99	regulation of superoxide anion generation (GO:0032928)	2.63345917
100	response to dietary excess (GO:0002021)	11.5297944

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.33094927
2	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.89583697
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.78995449
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.46148118
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.36945736
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.31401412
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.21160610
8	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.08390036
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.94839690
10	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.85533492
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.72786587
12	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.65302877
13	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.65004845
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.53108198
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.38138916
16	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.36580315
17	XRN2_22483619_ChIP-Seq_HELA_Human	2.24596475
18	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.22600716
19	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.19625567
20	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	2.08960251
21	KDM5A_27292631_Chip-Seq_BREAST_Human	2.07364360
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.03295554
23	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.99074441
24	DCP1A_22483619_ChIP-Seq_HELA_Human	1.98597841
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.97968323
26	TTF2_22483619_ChIP-Seq_HELA_Human	1.97241350
27	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.95143142
28	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.86744745
29	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.82459494
30	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.79990422
31	GABP_19822575_ChIP-Seq_HepG2_Human	1.77411389
32	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.76472306
33	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.68352920
34	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.65582137
35	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.64916955
36	ZNF263_19887448_ChIP-Seq_K562_Human	1.62904568
37	TFEB_21752829_ChIP-Seq_HELA_Human	1.58638712
38	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.57879157
39	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.55539975
40	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.55534028
41	FOXP3_21729870_ChIP-Seq_TREG_Human	1.53422391
42	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.53166905
43	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.44788456
44	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.44633422
45	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.43263048
46	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.40826950
47	VDR_23849224_ChIP-Seq_CD4+_Human	1.38536151
48	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.38074604
49	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.36898527
50	* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.34252128
51	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.33838271
52	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.33657225
53	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.32406731
54	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.30544593
55	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.30390416
56	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.29912458
57	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.27861932
58	AR_21909140_ChIP-Seq_LNCAP_Human	1.27711575
59	RBPJ_21746931_ChIP-Seq_IB4_Human	1.26525007
60	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.26484668
61	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.25523011
62	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.20389471
63	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.20002502
64	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.18932282
65	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.18190660
66	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.17562371
67	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.16993013
68	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.16504753
69	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.16170856
70	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.15656949
71	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.12259360
72	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.11634834
73	RACK7_27058665_Chip-Seq_MCF-7_Human	1.11587705
74	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.11268668
75	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.10620832
76	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.08455984
77	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.08120576
78	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.07923932
79	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.07460360
80	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.05379293
81	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.04610998
82	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.04046674
83	SA1_27219007_Chip-Seq_Bcells_Human	1.03073914
84	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.02182864
85	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.01940301
86	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.00052452
87	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.00032950
88	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.99750269
89	PHF8_20622853_ChIP-Seq_HELA_Human	0.99680610
90	ETV1_20927104_ChIP-Seq_GIST48_Human	0.96261937
91	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.95728443
92	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.95662908
93	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.95515428
94	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.94145849
95	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.92980338
96	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.92782716
97	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.92533015
98	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.90779468
99	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.89757380
100	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.89748525

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	8.90459601
2	MP0003136_yellow_coat_color	6.21614598
3	MP0008961_abnormal_basal_metabolism	4.53117120
4	MP0005408_hypopigmentation	4.46779061
5	MP0000372_irregular_coat_pigmentation	3.99224760
6	MP0005257_abnormal_intraocular_pressure	3.35667597
7	MP0005058_abnormal_lysosome_morphology	2.97742212
8	MP0003806_abnormal_nucleotide_metabolis	2.62171131
9	MP0008438_abnormal_cutaneous_collagen	2.52421423
10	MP0003186_abnormal_redox_activity	2.41807090
11	MP0000371_diluted_coat_color	2.36641114
12	MP0008260_abnormal_autophagy	2.28502395
13	MP0003693_abnormal_embryo_hatching	2.17982706
14	MP0002095_abnormal_skin_pigmentation	2.09297836
15	MP0004381_abnormal_hair_follicle	2.09033307
16	MP0008875_abnormal_xenobiotic_pharmacok	2.08163569
17	MP0004957_abnormal_blastocyst_morpholog	2.06973004
18	MP0000015_abnormal_ear_pigmentation	1.99827459
19	MP0002075_abnormal_coat/hair_pigmentati	1.91522245
20	MP0008932_abnormal_embryonic_tissue	1.89436014
21	MP0005075_abnormal_melanosome_morpholog	1.84004565
22	MP0003077_abnormal_cell_cycle	1.78653056
23	MP0009333_abnormal_splenocyte_physiolog	1.76780643
24	MP0005174_abnormal_tail_pigmentation	1.70375223
25	MP0003959_abnormal_lean_body	1.65864004
26	MP0002877_abnormal_melanocyte_morpholog	1.65429077
27	MP0003111_abnormal_nucleus_morphology	1.64104414
28	MP0001186_pigmentation_phenotype	1.59901317
29	MP0005670_abnormal_white_adipose	1.59380915
30	MP0002139_abnormal_hepatobiliary_system	1.56031231
31	MP0009840_abnormal_foam_cell	1.52138382
32	MP0002938_white_spotting	1.48456331
33	MP0010030_abnormal_orbit_morphology	1.48014267
34	MP0001324_abnormal_eye_pigmentation	1.46916767
35	MP0003718_maternal_effect	1.45833121
36	MP0010094_abnormal_chromosome_stability	1.34145290
37	MP0005266_abnormal_metabolism	1.29025992
38	MP0000358_abnormal_cell_content/	1.28189070
39	MP0001730_embryonic_growth_arrest	1.19400836
40	MP0001881_abnormal_mammary_gland	1.15084779
41	MP0005197_abnormal_uvea_morphology	1.14873373
42	MP0005451_abnormal_body_composition	1.13709253
43	MP0001502_abnormal_circadian_rhythm	1.13228978
44	MP0000579_abnormal_nail_morphology	1.08007138
45	MP0002210_abnormal_sex_determination	1.01616833
46	MP0000350_abnormal_cell_proliferation	0.99602605
47	MP0008872_abnormal_physiological_respon	0.98268171
48	MP0004019_abnormal_vitamin_homeostasis	0.95821274
49	MP0008058_abnormal_DNA_repair	0.94123050
50	MP0005319_abnormal_enzyme/_coenzyme	0.93016320
51	MP0005365_abnormal_bile_salt	0.92760438
52	MP0002080_prenatal_lethality	0.89830765
53	MP0008057_abnormal_DNA_replication	0.89634183
54	MP0005410_abnormal_fertilization	0.86554718
55	MP0004185_abnormal_adipocyte_glucose	0.85894204
56	MP0002295_abnormal_pulmonary_circulatio	0.85060350
57	MP0004272_abnormal_basement_membrane	0.83771271
58	MP0005085_abnormal_gallbladder_physiolo	0.83449182
59	MP0000639_abnormal_adrenal_gland	0.82628894
60	MP0006036_abnormal_mitochondrial_physio	0.82515048
61	MP0005165_increased_susceptibility_to	0.79412029
62	MP0006138_congestive_heart_failure	0.78119641
63	MP0003890_abnormal_embryonic-extraembry	0.77900777
64	MP0009697_abnormal_copulation	0.77410385
65	MP0005584_abnormal_enzyme/coenzyme_acti	0.77207444
66	MP0005636_abnormal_mineral_homeostasis	0.76271537
67	MP0001697_abnormal_embryo_size	0.75561932
68	MP0001672_abnormal_embryogenesis/_devel	0.75234968
69	MP0005380_embryogenesis_phenotype	0.75234968
70	MP0003699_abnormal_female_reproductive	0.74909372
71	MP0008007_abnormal_cellular_replicative	0.74756712
72	MP0005330_cardiomyopathy	0.74016190
73	MP0001145_abnormal_male_reproductive	0.73074072
74	MP0000490_abnormal_crypts_of	0.72490402
75	MP0003698_abnormal_male_reproductive	0.72249127
76	MP0003984_embryonic_growth_retardation	0.71556930
77	MP0002970_abnormal_white_adipose	0.70090003
78	MP0002796_impaired_skin_barrier	0.68746093
79	MP0002088_abnormal_embryonic_growth/wei	0.64645120
80	MP0001929_abnormal_gametogenesis	0.64370524
81	MP0008874_decreased_physiological_sensi	0.63015811
82	MP0000367_abnormal_coat/_hair	0.61061082
83	MP0003221_abnormal_cardiomyocyte_apopto	0.60904901
84	MP0006035_abnormal_mitochondrial_morpho	0.59762341
85	MP0000313_abnormal_cell_death	0.59182510
86	MP0005332_abnormal_amino_acid	0.59131776
87	MP0005384_cellular_phenotype	0.57347620
88	MP0003786_premature_aging	0.56767669
89	MP0002086_abnormal_extraembryonic_tissu	0.55990414
90	MP0001915_intracranial_hemorrhage	0.55982300
91	MP0008770_decreased_survivor_rate	0.55369350
92	MP0002085_abnormal_embryonic_tissue	0.54710158
93	MP0005501_abnormal_skin_physiology	0.54589923
94	MP0000653_abnormal_sex_gland	0.54365201
95	MP0002161_abnormal_fertility/fecundity	0.54046005
96	MP0001756_abnormal_urination	0.52731784
97	MP0000647_abnormal_sebaceous_gland	0.52496864
98	MP0003252_abnormal_bile_duct	0.52453263
99	MP0002060_abnormal_skin_morphology	0.52375538
100	MP0005376_homeostasis/metabolism_phenot	0.50280428

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the fovea (HP:0008060)	7.43939838
2	Hypoplasia of the fovea (HP:0007750)	7.43939838
3	Aplasia/Hypoplasia of the macula (HP:0008059)	6.69327288
4	White forelock (HP:0002211)	6.48326901
5	Patchy hypopigmentation of hair (HP:0011365)	6.40296703
6	Spastic paraparesis (HP:0002313)	6.36262936
7	Aplasia/Hypoplasia affecting the retina (HP:0008061)	6.28523477
8	Abnormality of the fovea (HP:0000493)	6.11993598
9	Cerebral hypomyelination (HP:0006808)	5.76187591
10	J-shaped sella turcica (HP:0002680)	4.54805950
11	Paraparesis (HP:0002385)	4.38315509
12	Blue irides (HP:0000635)	4.16796608
13	CNS hypomyelination (HP:0003429)	3.74914842
14	Ocular albinism (HP:0001107)	3.45249685
15	Premature graying of hair (HP:0002216)	3.39033040
16	Hypopigmentation of the fundus (HP:0007894)	3.37887744
17	Abnormal auditory evoked potentials (HP:0006958)	3.29764009
18	Heterochromia iridis (HP:0001100)	2.96593048
19	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.90278978
20	Abnormality of alanine metabolism (HP:0010916)	2.90278978
21	Hyperalaninemia (HP:0003348)	2.90278978
22	Abnormality of pyrimidine metabolism (HP:0004353)	2.85325700
23	Leukodystrophy (HP:0002415)	2.81286289
24	Iris hypopigmentation (HP:0007730)	2.78617458
25	Dysphonia (HP:0001618)	2.70814629
26	Abnormality of glycolipid metabolism (HP:0010969)	2.69436429
27	Abnormality of liposaccharide metabolism (HP:0010968)	2.69436429
28	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.69436429
29	Abnormal autonomic nervous system physiology (HP:0012332)	2.62550530
30	Reticulocytopenia (HP:0001896)	2.60116908
31	Anterior segment dysgenesis (HP:0007700)	2.59548302
32	Albinism (HP:0001022)	2.56158002
33	Morphological abnormality of the inner ear (HP:0011390)	2.51993567
34	Conjugated hyperbilirubinemia (HP:0002908)	2.47038369
35	Trismus (HP:0000211)	2.45891343
36	Hypokinesia (HP:0002375)	2.43273976
37	Generalized hypopigmentation (HP:0007513)	2.42482212
38	Sparse eyelashes (HP:0000653)	2.39496036
39	Esophageal neoplasm (HP:0100751)	2.36851689
40	Neoplasm of head and neck (HP:0012288)	2.36851689
41	Alacrima (HP:0000522)	2.31362819
42	Delusions (HP:0000746)	2.30808449
43	Large for gestational age (HP:0001520)	2.24705886
44	Deformed sella turcica (HP:0002681)	2.20516412
45	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.18007222
46	Conjunctival hamartoma (HP:0100780)	2.16330928
47	Nonimmune hydrops fetalis (HP:0001790)	2.12057363
48	Abnormality of cells of the erythroid lineage (HP:0012130)	2.09357526
49	Respiratory difficulties (HP:0002880)	2.08928366
50	Limb dystonia (HP:0002451)	2.06227349
51	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.03654504
52	Acute necrotizing encephalopathy (HP:0006965)	2.01316674
53	Premature rupture of membranes (HP:0001788)	2.01076333
54	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.97813451
55	Abnormal protein N-linked glycosylation (HP:0012347)	1.97813451
56	Abnormal protein glycosylation (HP:0012346)	1.97813451
57	Abnormal glycosylation (HP:0012345)	1.97813451
58	Overriding aorta (HP:0002623)	1.96237468
59	Microvesicular hepatic steatosis (HP:0001414)	1.94393014
60	Abnormal mitochondria in muscle tissue (HP:0008316)	1.94217512
61	Abnormality of methionine metabolism (HP:0010901)	1.94151679
62	Neurodegeneration (HP:0002180)	1.93874763
63	Cerebral edema (HP:0002181)	1.87859744
64	Osteolytic defects of the phalanges of the hand (HP:0009771)	1.87074170
65	Osteolytic defects of the hand bones (HP:0009699)	1.87074170
66	Cholecystitis (HP:0001082)	1.86035666
67	Abnormal gallbladder physiology (HP:0012438)	1.86035666
68	Patent foramen ovale (HP:0001655)	1.84189991
69	Upper limb muscle weakness (HP:0003484)	1.84173695
70	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.82231318
71	Distal lower limb muscle weakness (HP:0009053)	1.80686743
72	Multiple enchondromatosis (HP:0005701)	1.79851199
73	Death in childhood (HP:0003819)	1.79600316
74	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.79298639
75	Absent epiphyses (HP:0010577)	1.79298639
76	Generalized amyotrophy (HP:0003700)	1.78387432
77	Hypopigmented skin patches (HP:0001053)	1.77154574
78	Tongue fasciculations (HP:0001308)	1.77083508
79	Hypoplasia of the iris (HP:0007676)	1.77013084
80	Premature ovarian failure (HP:0008209)	1.76680004
81	Vacuolated lymphocytes (HP:0001922)	1.73989378
82	Posterior embryotoxon (HP:0000627)	1.73870926
83	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.73475234
84	Decreased lacrimation (HP:0000633)	1.71442559
85	Increased CSF lactate (HP:0002490)	1.70786199
86	Death in infancy (HP:0001522)	1.70385157
87	Abnormality of lateral ventricle (HP:0030047)	1.70167048
88	Achilles tendon contracture (HP:0001771)	1.67827512
89	Opisthotonus (HP:0002179)	1.67246576
90	Cutaneous melanoma (HP:0012056)	1.66934421
91	Increased serum lactate (HP:0002151)	1.66348071
92	Multiple lipomas (HP:0001012)	1.66070185
93	Ureteral duplication (HP:0000073)	1.65137149
94	Abnormal delivery (HP:0001787)	1.64591953
95	Poor speech (HP:0002465)	1.64051587
96	Xanthomatosis (HP:0000991)	1.64039630
97	Lower limb hyperreflexia (HP:0002395)	1.63672719
98	Hypomagnesemia (HP:0002917)	1.63098123
99	Type I transferrin isoform profile (HP:0003642)	1.59956568
100	Acute encephalopathy (HP:0006846)	1.59163034

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	8.16940565
2	PDK2	4.96690983
3	NEK1	4.82061594
4	EIF2AK1	3.66140462
5	NME2	3.02542802
6	EIF2AK3	2.68087900
7	ERN1	2.67291241
8	MST4	2.58680574
9	PIK3CG	2.52057178
10	SRPK1	2.45210904
11	MARK3	2.30820915
12	MAPKAPK3	2.14916158
13	TAOK3	2.05765035
14	STK16	1.98631781
15	WNK4	1.79815770
16	RPS6KB2	1.64563428
17	LMTK2	1.54623070
18	STK4	1.54487049
19	PRKD3	1.53922277
20	STK39	1.48544802
21	TSSK6	1.47400725
22	CDK3	1.39319758
23	PRPF4B	1.37577386
24	BUB1	1.34473109
25	BRSK1	1.30963706
26	MAP3K6	1.20298763
27	VRK2	1.15435057
28	ICK	1.06535097
29	MKNK1	1.00076194
30	CDK7	0.99988131
31	BRAF	0.98402929
32	DDR2	0.91706846
33	NEK2	0.85825964
34	PLK3	0.84762193
35	CHEK2	0.82132643
36	BMX	0.79730684
37	DMPK	0.78595886
38	PLK1	0.77382502
39	CHEK1	0.76528675
40	TRIB3	0.74568729
41	PAK4	0.73435859
42	WEE1	0.73310412
43	ILK	0.70641422
44	OXSR1	0.68140130
45	EEF2K	0.66131531
46	STK10	0.64689754
47	BRSK2	0.64218447
48	MAP3K8	0.62551225
49	CDK4	0.61449588
50	PHKG2	0.59999758
51	PHKG1	0.59999758
52	AKT2	0.59091426
53	SCYL2	0.54871911
54	CCNB1	0.54618656
55	MAP3K1	0.54142809
56	MKNK2	0.52638596
57	MET	0.52056379
58	TTK	0.51791015
59	PRKG2	0.50416537
60	CSNK2A2	0.48906791
61	LRRK2	0.48807758
62	ARAF	0.47469812
63	CDK11A	0.45108414
64	AURKB	0.44672270
65	MAP2K2	0.44085034
66	PKN2	0.42963249
67	PDPK1	0.42826673
68	ABL2	0.42445590
69	PAK1	0.40791956
70	AURKA	0.40383530
71	SIK3	0.39528180
72	CDK2	0.38756296
73	CSNK2A1	0.38186319
74	TESK2	0.37530371
75	LATS2	0.37285863
76	PINK1	0.36461562
77	MAPK12	0.35597008
78	CSNK1E	0.34538667
79	CDK1	0.34003507
80	MAPKAPK2	0.33681635
81	CDK15	0.31687472
82	PRKCI	0.30501202
83	PKN1	0.30306406
84	PIM1	0.29342348
85	CDK14	0.27689975
86	CDK18	0.27380029
87	MAPK11	0.27029234
88	ATR	0.26746979
89	SIK1	0.25915250
90	CDK8	0.25885918
91	CDK6	0.23029595
92	AKT1	0.22875114
93	FLT3	0.22668309
94	ATM	0.21523472
95	MAPK7	0.20136601
96	PDK1	0.20031872
97	RPS6KA1	0.19186724
98	CDC7	0.18937940
99	MAPK14	0.18800597
100	MARK2	0.17639201

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.70552668
2	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.61163315
3	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	3.16448175
4	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.99518722
5	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.97370039
6	Proteasome_Homo sapiens_hsa03050	2.87147340
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.77356515
8	Protein export_Homo sapiens_hsa03060	2.64359309
9	Parkinsons disease_Homo sapiens_hsa05012	2.52283822
10	DNA replication_Homo sapiens_hsa03030	2.23814237
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.19719222
12	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.16072019
13	Folate biosynthesis_Homo sapiens_hsa00790	2.05395228
14	Homologous recombination_Homo sapiens_hsa03440	1.97606039
15	Spliceosome_Homo sapiens_hsa03040	1.93503046
16	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.89837191
17	Huntingtons disease_Homo sapiens_hsa05016	1.89821867
18	RNA polymerase_Homo sapiens_hsa03020	1.84118586
19	RNA transport_Homo sapiens_hsa03013	1.83973323
20	Basal transcription factors_Homo sapiens_hsa03022	1.77358700
21	Tyrosine metabolism_Homo sapiens_hsa00350	1.74063728
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.69021101
23	Carbon metabolism_Homo sapiens_hsa01200	1.67478850
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.64836005
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.56841523
26	Pyruvate metabolism_Homo sapiens_hsa00620	1.50530401
27	Alzheimers disease_Homo sapiens_hsa05010	1.47491258
28	Pyrimidine metabolism_Homo sapiens_hsa00240	1.40764273
29	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.36547903
30	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.34070920
31	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.30588182
32	One carbon pool by folate_Homo sapiens_hsa00670	1.29349873
33	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.26889886
34	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.22660788
35	Sulfur relay system_Homo sapiens_hsa04122	1.18246921
36	Galactose metabolism_Homo sapiens_hsa00052	1.18231589
37	Mismatch repair_Homo sapiens_hsa03430	1.18009897
38	Pentose phosphate pathway_Homo sapiens_hsa00030	1.15834891
39	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.14303149
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.13689258
41	Base excision repair_Homo sapiens_hsa03410	1.12417936
42	Cardiac muscle contraction_Homo sapiens_hsa04260	1.10081589
43	Tryptophan metabolism_Homo sapiens_hsa00380	1.07985953
44	mRNA surveillance pathway_Homo sapiens_hsa03015	1.05236201
45	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.03691601
46	Lysosome_Homo sapiens_hsa04142	1.01634365
47	Regulation of autophagy_Homo sapiens_hsa04140	1.01074375
48	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.00356152
49	Vibrio cholerae infection_Homo sapiens_hsa05110	0.99618482
50	Cell cycle_Homo sapiens_hsa04110	0.96860174
51	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.96735559
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.95832331
53	Arginine biosynthesis_Homo sapiens_hsa00220	0.95020214
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91496204
55	Non-homologous end-joining_Homo sapiens_hsa03450	0.91235691
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89193345
57	Nucleotide excision repair_Homo sapiens_hsa03420	0.85606404
58	Fatty acid elongation_Homo sapiens_hsa00062	0.83932739
59	Other glycan degradation_Homo sapiens_hsa00511	0.81768613
60	Purine metabolism_Homo sapiens_hsa00230	0.80722978
61	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.79275733
62	Metabolic pathways_Homo sapiens_hsa01100	0.77157006
63	ABC transporters_Homo sapiens_hsa02010	0.76702458
64	Retinol metabolism_Homo sapiens_hsa00830	0.76362090
65	Prion diseases_Homo sapiens_hsa05020	0.75785418
66	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.74951140
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.74375615
68	Sulfur metabolism_Homo sapiens_hsa00920	0.68202999
69	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.59139096
70	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.59087491
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56351301
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.54305460
73	Antigen processing and presentation_Homo sapiens_hsa04612	0.52986341
74	RNA degradation_Homo sapiens_hsa03018	0.51693959
75	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.51423400
76	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.44737478
77	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.42436657
78	Complement and coagulation cascades_Homo sapiens_hsa04610	0.41918973
79	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.41022193
80	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.39422104
81	Steroid biosynthesis_Homo sapiens_hsa00100	0.39332923
82	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.37801984
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.36866692
84	Lysine degradation_Homo sapiens_hsa00310	0.36452541
85	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.34800597
86	Viral carcinogenesis_Homo sapiens_hsa05203	0.34442220
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34088680
88	Apoptosis_Homo sapiens_hsa04210	0.33273734
89	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.31458433
90	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.27955728
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.26209411
92	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.26103099
93	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.25562071
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.24631451
95	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.24617079
96	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.24454789
97	Small cell lung cancer_Homo sapiens_hsa05222	0.23308108
98	Glutathione metabolism_Homo sapiens_hsa00480	0.22261509
99	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.22138139
100	Bile secretion_Homo sapiens_hsa04976	0.20770917

GAGE12H

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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