ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	5.48147506
2	proteasome assembly (GO:0043248)	5.24267650
3	formation of translation preinitiation complex (GO:0001731)	5.09742574
4	nuclear pore organization (GO:0006999)	4.82714501
5	regulation of translational fidelity (GO:0006450)	4.51936301
6	DNA unwinding involved in DNA replication (GO:0006268)	4.27073122
7	mitotic nuclear envelope disassembly (GO:0007077)	4.14249741
8	pore complex assembly (GO:0046931)	4.11002350
9	ribosome assembly (GO:0042255)	4.09959066
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.09073211
11	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.05296665
12	purine nucleobase biosynthetic process (GO:0009113)	4.01704521
13	DNA replication checkpoint (GO:0000076)	4.01248653
14	synapsis (GO:0007129)	4.00798953
15	ribosomal large subunit biogenesis (GO:0042273)	3.98794539
16	ribosome biogenesis (GO:0042254)	3.97366082
17	homocysteine metabolic process (GO:0050667)	3.92885360
18	DNA replication initiation (GO:0006270)	3.92830062
19	tRNA aminoacylation for protein translation (GO:0006418)	3.92401126
20	DNA strand elongation involved in DNA replication (GO:0006271)	3.89786908
21	rRNA modification (GO:0000154)	3.87451326
22	ribonucleoprotein complex biogenesis (GO:0022613)	3.83047436
23	mitotic sister chromatid segregation (GO:0000070)	3.79611721
24	amino acid activation (GO:0043038)	3.79163495
25	tRNA aminoacylation (GO:0043039)	3.79163495
26	telomere maintenance via semi-conservative replication (GO:0032201)	3.78686150
27	membrane disassembly (GO:0030397)	3.77620838
28	nuclear envelope disassembly (GO:0051081)	3.77620838
29	rRNA methylation (GO:0031167)	3.77425912
30	nucleobase biosynthetic process (GO:0046112)	3.76692941
31	DNA strand elongation (GO:0022616)	3.75738000
32	maturation of 5.8S rRNA (GO:0000460)	3.70992272
33	piRNA metabolic process (GO:0034587)	3.68135916
34	mitotic metaphase plate congression (GO:0007080)	3.58440237
35	ribosomal small subunit biogenesis (GO:0042274)	3.56022380
36	ATP synthesis coupled proton transport (GO:0015986)	3.50563059
37	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.50563059
38	male meiosis (GO:0007140)	3.47970905
39	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.46548787
40	mitotic recombination (GO:0006312)	3.46001391
41	sister chromatid segregation (GO:0000819)	3.41641373
42	mitotic chromosome condensation (GO:0007076)	3.40279543
43	maturation of SSU-rRNA (GO:0030490)	3.39982441
44	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.38927406
45	cullin deneddylation (GO:0010388)	3.38772345
46	DNA methylation involved in gamete generation (GO:0043046)	3.34974655
47	telomere maintenance via recombination (GO:0000722)	3.34709030
48	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.33885823
49	oxidative phosphorylation (GO:0006119)	3.32889994
50	negative regulation of protein acetylation (GO:1901984)	3.32605494
51	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.31102030
52	pseudouridine synthesis (GO:0001522)	3.29291151
53	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.28697664
54	negative regulation of ligase activity (GO:0051352)	3.27888813
55	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.27888813
56	respiratory electron transport chain (GO:0022904)	3.24641753
57	IMP biosynthetic process (GO:0006188)	3.23356317
58	positive regulation of ligase activity (GO:0051351)	3.22532873
59	protein targeting to mitochondrion (GO:0006626)	3.19745486
60	rRNA processing (GO:0006364)	3.19228610
61	electron transport chain (GO:0022900)	3.16468522
62	regulation of mitotic spindle organization (GO:0060236)	3.15427145
63	chromosome organization involved in meiosis (GO:0070192)	3.14236583
64	folic acid-containing compound biosynthetic process (GO:0009396)	3.13603494
65	cellular component biogenesis (GO:0044085)	3.12359886
66	translational initiation (GO:0006413)	3.11405770
67	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.09689388
68	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.09689388
69	regulation of cellular amino acid metabolic process (GO:0006521)	3.09285918
70	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.08432976
71	CENP-A containing nucleosome assembly (GO:0034080)	3.08267151
72	protein deneddylation (GO:0000338)	3.08228959
73	nucleobase-containing small molecule interconversion (GO:0015949)	3.08209497
74	regulation of ubiquitin-protein transferase activity (GO:0051438)	3.07688320
75	rRNA metabolic process (GO:0016072)	3.07583689
76	ribosomal small subunit assembly (GO:0000028)	3.07520745
77	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.07304697
78	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.07304697
79	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.07304697
80	regulation of translational elongation (GO:0006448)	3.05836330
81	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.05745486
82	resolution of meiotic recombination intermediates (GO:0000712)	3.05348474
83	terpenoid biosynthetic process (GO:0016114)	3.05089241
84	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.04505608
85	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.04505608
86	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.04046502
87	nuclear envelope organization (GO:0006998)	3.01743993
88	translation (GO:0006412)	3.00520069
89	chromosome segregation (GO:0007059)	2.99567981
90	diterpenoid biosynthetic process (GO:0016102)	2.97635100
91	meiotic chromosome segregation (GO:0045132)	2.97564124
92	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.96784290
93	regulation of ligase activity (GO:0051340)	2.95205076
94	metaphase plate congression (GO:0051310)	2.94997347
95	protein localization to mitochondrion (GO:0070585)	2.94213128
96	mitochondrial RNA metabolic process (GO:0000959)	2.92754509
97	establishment of integrated proviral latency (GO:0075713)	2.92694514
98	establishment of protein localization to mitochondrion (GO:0072655)	2.86916458
99	pteridine-containing compound biosynthetic process (GO:0042559)	2.83960304
100	kinetochore organization (GO:0051383)	2.82888078

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.64942347
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.18826070
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.82180175
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.57472921
5	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.49467448
6	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.44771753
7	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.41409113
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.28198732
9	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.19286732
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.19142516
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.16313489
12	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.05171690
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.97918948
14	ZNF263_19887448_ChIP-Seq_K562_Human	2.84526830
15	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.80499105
16	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.62135236
17	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.59913904
18	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.58527326
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.44437043
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.40637373
21	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.36720077
22	AR_21909140_ChIP-Seq_LNCAP_Human	2.32351599
23	DCP1A_22483619_ChIP-Seq_HELA_Human	2.30419636
24	XRN2_22483619_ChIP-Seq_HELA_Human	2.30155042
25	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.23192365
26	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.22455887
27	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.18528372
28	TTF2_22483619_ChIP-Seq_HELA_Human	2.04326603
29	VDR_23849224_ChIP-Seq_CD4+_Human	2.02590893
30	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.02107887
31	FOXP3_21729870_ChIP-Seq_TREG_Human	1.96169917
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.93942049
33	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.88737897
34	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.88132890
35	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.85295123
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.84331222
37	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.83828363
38	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.82811625
39	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.74459879
40	KDM5A_27292631_Chip-Seq_BREAST_Human	1.71614338
41	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.71589403
42	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.70385035
43	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.70084276
44	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.69754092
45	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.69586734
46	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.63908514
47	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.60604960
48	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.57311695
49	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.56138770
50	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.51320372
51	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.51244149
52	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.50446252
53	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.49673037
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.49020334
55	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.45780390
56	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.42597732
57	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.39924052
58	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.35104110
59	TFEB_21752829_ChIP-Seq_HELA_Human	1.26295853
60	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.26287319
61	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.25744405
62	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.23316214
63	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.22763938
64	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.20054926
65	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.19785776
66	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.17326932
67	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.15746376
68	MYC_18940864_ChIP-ChIP_HL60_Human	1.15079988
69	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.14328158
70	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.09881084
71	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.09748298
72	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.09245148
73	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.08951194
74	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.08714969
75	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.08591958
76	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.07347534
77	NCOR1_26117541_ChIP-Seq_K562_Human	1.04377737
78	CIITA_25753668_ChIP-Seq_RAJI_Human	1.03589000
79	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.03439082
80	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.00043238
81	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.98203907
82	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.95408632
83	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.94993031
84	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.93734485
85	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.93475435
86	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.91285927
87	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.90139726
88	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.89423507
89	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.88385381
90	CHD1_26751641_Chip-Seq_LNCaP_Human	0.86928273
91	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.85713094
92	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.84539650
93	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.83515117
94	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.80277424
95	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.79695531
96	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.78199775
97	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.75649929
98	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.74790646
99	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.73574647
100	GATA4_21415370_ChIP-Seq_HL-1_Mouse	0.73572751

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008058_abnormal_DNA_repair	4.18905850
2	MP0010094_abnormal_chromosome_stability	4.10474540
3	MP0003786_premature_aging	4.06588894
4	MP0004957_abnormal_blastocyst_morpholog	4.06248142
5	MP0003111_abnormal_nucleus_morphology	3.97777902
6	MP0008995_early_reproductive_senescence	3.77099923
7	MP0003693_abnormal_embryo_hatching	3.43713862
8	MP0009697_abnormal_copulation	3.42529177
9	MP0003077_abnormal_cell_cycle	3.15931831
10	MP0003806_abnormal_nucleotide_metabolis	2.93805226
11	MP0008057_abnormal_DNA_replication	2.72734485
12	MP0008932_abnormal_embryonic_tissue	2.56428088
13	MP0003186_abnormal_redox_activity	2.54254888
14	MP0008007_abnormal_cellular_replicative	2.48008080
15	MP0004084_abnormal_cardiac_muscle	2.45613881
16	MP0003718_maternal_effect	2.44580198
17	MP0005408_hypopigmentation	2.43406081
18	MP0006036_abnormal_mitochondrial_physio	2.13796073
19	MP0006035_abnormal_mitochondrial_morpho	1.96243502
20	MP0005171_absent_coat_pigmentation	1.89008233
21	MP0005451_abnormal_body_composition	1.83862828
22	MP0004147_increased_porphyrin_level	1.77019565
23	MP0010307_abnormal_tumor_latency	1.74420232
24	MP0008775_abnormal_heart_ventricle	1.68713217
25	MP0001730_embryonic_growth_arrest	1.65396063
26	MP0000358_abnormal_cell_content/	1.64782776
27	MP0000372_irregular_coat_pigmentation	1.64459284
28	MP0000350_abnormal_cell_proliferation	1.64164426
29	MP0002210_abnormal_sex_determination	1.61299037
30	MP0001697_abnormal_embryo_size	1.54837248
31	MP0001929_abnormal_gametogenesis	1.51624634
32	MP0002877_abnormal_melanocyte_morpholog	1.51338776
33	MP0000313_abnormal_cell_death	1.48901229
34	MP0002080_prenatal_lethality	1.39564519
35	MP0004036_abnormal_muscle_relaxation	1.39026744
36	MP0001881_abnormal_mammary_gland	1.37278977
37	MP0009379_abnormal_foot_pigmentation	1.31425827
38	MP0001661_extended_life_span	1.30995366
39	MP0006138_congestive_heart_failure	1.28481662
40	MP0003656_abnormal_erythrocyte_physiolo	1.26999483
41	MP0001672_abnormal_embryogenesis/_devel	1.26614801
42	MP0005380_embryogenesis_phenotype	1.26614801
43	MP0004233_abnormal_muscle_weight	1.23236828
44	MP0001764_abnormal_homeostasis	1.21852375
45	MP0004484_altered_response_of	1.17474741
46	MP0003984_embryonic_growth_retardation	1.17310304
47	MP0001145_abnormal_male_reproductive	1.16435278
48	MP0002160_abnormal_reproductive_system	1.15665440
49	MP0000015_abnormal_ear_pigmentation	1.13062403
50	MP0005330_cardiomyopathy	1.13047171
51	MP0002088_abnormal_embryonic_growth/wei	1.12879157
52	MP0000653_abnormal_sex_gland	1.11180919
53	MP0002396_abnormal_hematopoietic_system	1.08762578
54	MP0008877_abnormal_DNA_methylation	1.07087404
55	MP0002095_abnormal_skin_pigmentation	1.06058625
56	MP0005501_abnormal_skin_physiology	1.01187711
57	MP0003698_abnormal_male_reproductive	0.99100427
58	MP0002086_abnormal_extraembryonic_tissu	0.97133856
59	MP0009333_abnormal_splenocyte_physiolog	0.95812518
60	MP0005332_abnormal_amino_acid	0.92996152
61	MP0002132_abnormal_respiratory_system	0.92906709
62	MP0003959_abnormal_lean_body	0.91522951
63	MP0005083_abnormal_biliary_tract	0.90031961
64	MP0002019_abnormal_tumor_incidence	0.89326205
65	MP0002938_white_spotting	0.86579045
66	MP0005389_reproductive_system_phenotype	0.86289018
67	MP0003136_yellow_coat_color	0.85089018
68	MP0005410_abnormal_fertilization	0.83875506
69	MP0002084_abnormal_developmental_patter	0.82438344
70	MP0002085_abnormal_embryonic_tissue	0.81669880
71	MP0005165_increased_susceptibility_to	0.79312281
72	MP0004858_abnormal_nervous_system	0.78315183
73	MP0003828_pulmonary_edema	0.78258224
74	MP0002161_abnormal_fertility/fecundity	0.77897095
75	MP0008875_abnormal_xenobiotic_pharmacok	0.75292239
76	MP0004185_abnormal_adipocyte_glucose	0.75205120
77	MP0005384_cellular_phenotype	0.74289377
78	MP0003943_abnormal_hepatobiliary_system	0.74268274
79	MP0000678_abnormal_parathyroid_gland	0.71690846
80	MP0003699_abnormal_female_reproductive	0.71326356
81	MP0008770_decreased_survivor_rate	0.70953876
82	MP0001119_abnormal_female_reproductive	0.69660597
83	MP0001919_abnormal_reproductive_system	0.68925441
84	MP0005395_other_phenotype	0.68754401
85	MP0005197_abnormal_uvea_morphology	0.68735657
86	MP0002269_muscular_atrophy	0.68654670
87	MP0001186_pigmentation_phenotype	0.67814755
88	MP0004197_abnormal_fetal_growth/weight/	0.66561809
89	MP0001348_abnormal_lacrimal_gland	0.66306579
90	MP0000627_abnormal_mammary_gland	0.65460795
91	MP0005636_abnormal_mineral_homeostasis	0.61878898
92	MP0004808_abnormal_hematopoietic_stem	0.61459660
93	MP0000609_abnormal_liver_physiology	0.61051642
94	MP0010030_abnormal_orbit_morphology	0.60986173
95	MP0005266_abnormal_metabolism	0.60760005
96	MP0002075_abnormal_coat/hair_pigmentati	0.59583078
97	MP0000598_abnormal_liver_morphology	0.59294144
98	MP0000647_abnormal_sebaceous_gland	0.58688995
99	MP0003936_abnormal_reproductive_system	0.57529771
100	MP0003950_abnormal_plasma_membrane	0.57481453

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromosomal breakage induced by crosslinking agents (HP:0003221)	5.09411939
2	Chromsome breakage (HP:0040012)	4.76820621
3	Acute encephalopathy (HP:0006846)	4.07401626
4	Acute necrotizing encephalopathy (HP:0006965)	3.96493509
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.85504424
6	Abnormality of the preputium (HP:0100587)	3.74959613
7	Increased CSF lactate (HP:0002490)	3.70110748
8	Reticulocytopenia (HP:0001896)	3.67806257
9	Cerebral edema (HP:0002181)	3.50271314
10	Cholecystitis (HP:0001082)	3.44816534
11	Abnormal gallbladder physiology (HP:0012438)	3.44816534
12	Abnormality of glycolysis (HP:0004366)	3.41664011
13	Birth length less than 3rd percentile (HP:0003561)	3.37970463
14	Mitochondrial inheritance (HP:0001427)	3.35818655
15	Increased hepatocellular lipid droplets (HP:0006565)	3.20815408
16	Duplicated collecting system (HP:0000081)	3.20456423
17	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.19443728
18	Progressive macrocephaly (HP:0004481)	3.16866448
19	Hyperthyroidism (HP:0000836)	3.14637422
20	Abnormality of DNA repair (HP:0003254)	3.13141784
21	Cerebral hypomyelination (HP:0006808)	3.04512302
22	Entropion (HP:0000621)	3.03135974
23	Hepatocellular necrosis (HP:0001404)	3.00534607
24	Lipid accumulation in hepatocytes (HP:0006561)	2.96621854
25	Meckel diverticulum (HP:0002245)	2.92441281
26	Increased serum pyruvate (HP:0003542)	2.91114544
27	Upper limb muscle weakness (HP:0003484)	2.90056802
28	Abnormality of chromosome stability (HP:0003220)	2.85960812
29	Abnormality of the renal collecting system (HP:0004742)	2.81756800
30	Renal Fanconi syndrome (HP:0001994)	2.80420515
31	Increased serum lactate (HP:0002151)	2.79619443
32	Ureteral duplication (HP:0000073)	2.79331761
33	Abnormality of the ileum (HP:0001549)	2.74426053
34	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.70372353
35	Abnormality of the tricuspid valve (HP:0001702)	2.67306145
36	Lactic acidosis (HP:0003128)	2.60573117
37	Pallor (HP:0000980)	2.60026926
38	Respiratory difficulties (HP:0002880)	2.59867217
39	Hepatic necrosis (HP:0002605)	2.58635530
40	Seborrheic dermatitis (HP:0001051)	2.56594750
41	Abnormality of alanine metabolism (HP:0010916)	2.51487939
42	Hyperalaninemia (HP:0003348)	2.51487939
43	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.51487939
44	Small intestinal stenosis (HP:0012848)	2.49791027
45	Duodenal stenosis (HP:0100867)	2.49791027
46	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.49591901
47	Abnormality of methionine metabolism (HP:0010901)	2.49549862
48	Abnormality of pyrimidine metabolism (HP:0004353)	2.47319423
49	Abnormality of reticulocytes (HP:0004312)	2.45506433
50	Secondary amenorrhea (HP:0000869)	2.45359283
51	Truncus arteriosus (HP:0001660)	2.41671961
52	Absent thumb (HP:0009777)	2.38811280
53	Abnormality of the carotid arteries (HP:0005344)	2.34429571
54	Myelodysplasia (HP:0002863)	2.34204239
55	Respiratory failure (HP:0002878)	2.26379877
56	Exercise intolerance (HP:0003546)	2.24290540
57	Neuroendocrine neoplasm (HP:0100634)	2.20412594
58	Short middle phalanx of the 5th finger (HP:0004220)	2.19057646
59	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.19056523
60	Hypoparathyroidism (HP:0000829)	2.17812782
61	Pheochromocytoma (HP:0002666)	2.13653470
62	Spastic paraparesis (HP:0002313)	2.12561786
63	CNS hypomyelination (HP:0003429)	2.12133424
64	Conjunctival hamartoma (HP:0100780)	2.11605105
65	Cutaneous melanoma (HP:0012056)	2.10693391
66	Cortical dysplasia (HP:0002539)	2.10567217
67	Increased intramyocellular lipid droplets (HP:0012240)	2.09384964
68	Macrocytic anemia (HP:0001972)	2.09248069
69	CNS demyelination (HP:0007305)	2.07460467
70	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.06672451
71	Tinnitus (HP:0000360)	2.05745259
72	Homocystinuria (HP:0002156)	2.03979683
73	Abnormality of homocysteine metabolism (HP:0010919)	2.03979683
74	Abnormal hemoglobin (HP:0011902)	2.03974777
75	Microvesicular hepatic steatosis (HP:0001414)	2.02253619
76	Sparse eyelashes (HP:0000653)	2.02070267
77	Leukodystrophy (HP:0002415)	2.00978297
78	Lethargy (HP:0001254)	2.00473296
79	Abnormality of cells of the erythroid lineage (HP:0012130)	1.99418933
80	Exertional dyspnea (HP:0002875)	1.96657579
81	Decreased subcutaneous fat (HP:0001002)	1.96578960
82	Neoplasm of the peripheral nervous system (HP:0100007)	1.95448964
83	Clubbing of toes (HP:0100760)	1.94144749
84	Emotional lability (HP:0000712)	1.89235586
85	Reticulocytosis (HP:0001923)	1.87574937
86	Sloping forehead (HP:0000340)	1.85623036
87	Congenital ichthyosiform erythroderma (HP:0007431)	1.85427249
88	Type I transferrin isoform profile (HP:0003642)	1.83882839
89	Breast hypoplasia (HP:0003187)	1.83858351
90	Horseshoe kidney (HP:0000085)	1.83537362
91	Hypertensive crisis (HP:0100735)	1.81271318
92	X-linked dominant inheritance (HP:0001423)	1.81002141
93	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.80025596
94	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.78889208
95	Submucous cleft hard palate (HP:0000176)	1.78713821
96	Increased nuchal translucency (HP:0010880)	1.78104811
97	Poikiloderma (HP:0001029)	1.77489673
98	Pancytopenia (HP:0001876)	1.77174149
99	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.77126633
100	Abnormality of the duodenum (HP:0002246)	1.75423563

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	4.62676971
2	SIK3	4.51329679
3	EIF2AK1	4.46226941
4	PBK	3.81391895
5	PDK2	3.54954261
6	NEK1	3.39381935
7	NME2	2.91368815
8	MAP3K3	2.81765680
9	EIF2AK3	2.75530816
10	BUB1	2.73011214
11	MST4	2.63066929
12	CDC7	2.28562487
13	TTK	2.27878533
14	BCR	2.14591559
15	SRPK1	2.05781563
16	BRSK2	2.05520021
17	MST1R	2.00440159
18	STK16	1.98959909
19	CCNB1	1.75922759
20	KSR1	1.73209040
21	EEF2K	1.70844979
22	BRSK1	1.64193233
23	PLK4	1.59398940
24	TSSK6	1.59106910
25	WEE1	1.51775525
26	IRAK3	1.45757933
27	BMPR2	1.45231529
28	PAK4	1.37160689
29	MKNK1	1.32651627
30	CHEK2	1.25984444
31	ERBB3	1.23029051
32	NME1	1.22352468
33	ICK	1.20008741
34	MAP3K12	1.18518971
35	ILK	1.09936006
36	NEK2	1.03803614
37	MET	1.03568775
38	PLK1	1.00412741
39	AURKB	0.94294670
40	PLK3	0.94064547
41	ATR	0.92480950
42	MAP3K8	0.89748472
43	RPS6KB2	0.88932198
44	STK4	0.83367014
45	CHEK1	0.83350844
46	STK10	0.81173015
47	BRAF	0.75388431
48	ALK	0.74931995
49	CLK1	0.74173535
50	MARK3	0.73109553
51	SCYL2	0.70891849
52	TRIB3	0.66821025
53	RAF1	0.65366535
54	EIF2AK2	0.64700702
55	MKNK2	0.63180903
56	PNCK	0.62666019
57	CDK8	0.62288152
58	VRK2	0.59295401
59	ATM	0.57893644
60	CDK1	0.54480474
61	CSNK2A2	0.52777961
62	AKT2	0.52766357
63	ERBB4	0.51622399
64	CDK2	0.51442357
65	LRRK2	0.49903143
66	WNK4	0.49116298
67	CDK7	0.48589406
68	PRKCI	0.48451246
69	DMPK	0.48173286
70	PAK1	0.45921685
71	AURKA	0.43878510
72	CSNK2A1	0.42742144
73	STK3	0.42384889
74	MINK1	0.39206260
75	CSNK1E	0.38565854
76	PIK3CG	0.38215364
77	STK39	0.37729306
78	KSR2	0.37206661
79	NUAK1	0.34554942
80	EPHA2	0.33138132
81	SIK1	0.30289398
82	BMX	0.29058702
83	TRPM7	0.28406783
84	MAPKAPK2	0.28328866
85	PKN2	0.27937863
86	CDK4	0.26853456
87	PRKDC	0.25499659
88	PASK	0.25222530
89	CDK18	0.25099535
90	DYRK1A	0.24317884
91	CDK3	0.23670015
92	MOS	0.23318649
93	FLT3	0.22733897
94	MAPK14	0.20735579
95	GSK3A	0.20710320
96	PLK2	0.19347969
97	MAPKAPK5	0.17947355
98	MAPKAPK3	0.17261233
99	MAP3K2	0.17055513
100	ZAK	0.16929065

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.00060260
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.84366554
3	DNA replication_Homo sapiens_hsa03030	3.73150156
4	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.63864589
5	Ribosome_Homo sapiens_hsa03010	3.13992356
6	Mismatch repair_Homo sapiens_hsa03430	3.10972888
7	Homologous recombination_Homo sapiens_hsa03440	2.84719275
8	RNA transport_Homo sapiens_hsa03013	2.73538067
9	Parkinsons disease_Homo sapiens_hsa05012	2.72115529
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.71213819
11	One carbon pool by folate_Homo sapiens_hsa00670	2.55393291
12	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.54634072
13	RNA polymerase_Homo sapiens_hsa03020	2.50241965
14	Spliceosome_Homo sapiens_hsa03040	2.40538283
15	Fanconi anemia pathway_Homo sapiens_hsa03460	2.40271754
16	Nucleotide excision repair_Homo sapiens_hsa03420	2.23952280
17	Huntingtons disease_Homo sapiens_hsa05016	2.00952085
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.95903322
19	Basal transcription factors_Homo sapiens_hsa03022	1.90159902
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.86349944
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.84568447
22	Alzheimers disease_Homo sapiens_hsa05010	1.80951889
23	Cell cycle_Homo sapiens_hsa04110	1.80688128
24	Carbon metabolism_Homo sapiens_hsa01200	1.66485484
25	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.64671086
26	Base excision repair_Homo sapiens_hsa03410	1.59289046
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.51139265
28	mRNA surveillance pathway_Homo sapiens_hsa03015	1.48879394
29	Pyruvate metabolism_Homo sapiens_hsa00620	1.44113538
30	Protein export_Homo sapiens_hsa03060	1.43530449
31	RNA degradation_Homo sapiens_hsa03018	1.43339539
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.36820449
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.26994461
34	Fatty acid elongation_Homo sapiens_hsa00062	1.21298876
35	Purine metabolism_Homo sapiens_hsa00230	1.20280607
36	Pentose phosphate pathway_Homo sapiens_hsa00030	1.14419996
37	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.13111668
38	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.06175603
39	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.05748737
40	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.03887030
41	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.03880584
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.00152932
43	Propanoate metabolism_Homo sapiens_hsa00640	0.97152402
44	Folate biosynthesis_Homo sapiens_hsa00790	0.96645453
45	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.93759201
46	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.91192374
47	Cardiac muscle contraction_Homo sapiens_hsa04260	0.89808109
48	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.89208505
49	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.87322575
50	Oocyte meiosis_Homo sapiens_hsa04114	0.87279173
51	Arginine biosynthesis_Homo sapiens_hsa00220	0.84072123
52	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.75160017
53	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.67938990
54	Metabolic pathways_Homo sapiens_hsa01100	0.67584690
55	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.65907435
56	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.64415660
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.63647448
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.57174292
59	Glutathione metabolism_Homo sapiens_hsa00480	0.56037205
60	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.54353886
61	Tyrosine metabolism_Homo sapiens_hsa00350	0.52917047
62	Lysine degradation_Homo sapiens_hsa00310	0.52780123
63	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.51637164
64	p53 signaling pathway_Homo sapiens_hsa04115	0.51278263
65	Sulfur metabolism_Homo sapiens_hsa00920	0.50211270
66	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.47904578
67	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.44390844
68	Sulfur relay system_Homo sapiens_hsa04122	0.43724614
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.42532177
70	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.42486062
71	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.39740273
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39724408
73	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.39637534
74	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.32930399
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.32365515
76	Viral carcinogenesis_Homo sapiens_hsa05203	0.27867572
77	Butanoate metabolism_Homo sapiens_hsa00650	0.25444177
78	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.21728855
79	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.21175755
80	Phenylalanine metabolism_Homo sapiens_hsa00360	0.20255781
81	Small cell lung cancer_Homo sapiens_hsa05222	0.18049781
82	Olfactory transduction_Homo sapiens_hsa04740	0.17405612
83	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.15747018
84	Galactose metabolism_Homo sapiens_hsa00052	0.14991409
85	Arginine and proline metabolism_Homo sapiens_hsa00330	0.14879413
86	Other glycan degradation_Homo sapiens_hsa00511	0.12033439
87	MicroRNAs in cancer_Homo sapiens_hsa05206	0.09574400
88	Apoptosis_Homo sapiens_hsa04210	0.09543634
89	Nitrogen metabolism_Homo sapiens_hsa00910	0.08737713
90	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.08266995
91	Regulation of autophagy_Homo sapiens_hsa04140	0.06923139
92	Ether lipid metabolism_Homo sapiens_hsa00565	0.06245486
93	Herpes simplex infection_Homo sapiens_hsa05168	0.04596842
94	Pancreatic cancer_Homo sapiens_hsa05212	0.02582320
95	Mineral absorption_Homo sapiens_hsa04978	-0.0646942
96	Peroxisome_Homo sapiens_hsa04146	-0.0646791
97	Non-small cell lung cancer_Homo sapiens_hsa05223	-0.0525363
98	Thyroid cancer_Homo sapiens_hsa05216	-0.0338626
99	Chronic myeloid leukemia_Homo sapiens_hsa05220	-0.0150782
100	Legionellosis_Homo sapiens_hsa05134	-0.0128699

GAGE12J

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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