GAGE2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sexual reproduction (GO:0019953)6.33695491
2nuclear pore complex assembly (GO:0051292)5.99945201
3regulation of translational fidelity (GO:0006450)5.48636031
4formation of translation preinitiation complex (GO:0001731)5.43476082
5response to dietary excess (GO:0002021)5.26861369
6nuclear pore organization (GO:0006999)5.21412495
7homocysteine metabolic process (GO:0050667)4.89990356
8DNA replication checkpoint (GO:0000076)4.79674877
9oxidative phosphorylation (GO:0006119)4.56667080
10DNA unwinding involved in DNA replication (GO:0006268)4.50518654
11pore complex assembly (GO:0046931)4.42759123
12ribosomal large subunit biogenesis (GO:0042273)4.29680071
13DNA replication initiation (GO:0006270)4.27421535
14tRNA aminoacylation for protein translation (GO:0006418)4.17596544
15diterpenoid biosynthetic process (GO:0016102)4.16151171
16mitotic nuclear envelope disassembly (GO:0007077)4.14983733
17Golgi transport vesicle coating (GO:0048200)4.04730489
18COPI coating of Golgi vesicle (GO:0048205)4.04730489
19DNA strand elongation involved in DNA replication (GO:0006271)4.03078945
20tRNA aminoacylation (GO:0043039)4.02636895
21amino acid activation (GO:0043038)4.02636895
22mitotic sister chromatid segregation (GO:0000070)4.01527257
23DNA strand elongation (GO:0022616)3.94060996
24ribonucleoprotein complex biogenesis (GO:0022613)3.88771349
25ribosome biogenesis (GO:0042254)3.86533803
26ribosomal small subunit biogenesis (GO:0042274)3.82505867
27nuclear envelope disassembly (GO:0051081)3.80499483
28membrane disassembly (GO:0030397)3.80499483
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.75716079
30sister chromatid segregation (GO:0000819)3.68155808
31proline biosynthetic process (GO:0006561)3.65417503
32terpenoid biosynthetic process (GO:0016114)3.64225636
33telomere maintenance via semi-conservative replication (GO:0032201)3.63887369
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.60838314
35ribosome assembly (GO:0042255)3.58480232
36regulation of RNA export from nucleus (GO:0046831)3.54832236
37midgut development (GO:0007494)3.53762895
38mitotic chromosome condensation (GO:0007076)3.53577208
39protoporphyrinogen IX metabolic process (GO:0046501)3.53485965
40proteasome assembly (GO:0043248)3.44686957
41oxaloacetate metabolic process (GO:0006107)3.44155379
42maturation of SSU-rRNA (GO:0030490)3.42335112
43viral transcription (GO:0019083)3.39946387
44maturation of 5.8S rRNA (GO:0000460)3.35307472
45purine nucleobase biosynthetic process (GO:0009113)3.33308955
46translational termination (GO:0006415)3.31723806
47translational initiation (GO:0006413)3.31295449
48nucleobase-containing small molecule interconversion (GO:0015949)3.31068268
49regulation of histone H3-K27 methylation (GO:0061085)3.29459693
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.29198169
51folic acid-containing compound biosynthetic process (GO:0009396)3.28781401
52resolution of meiotic recombination intermediates (GO:0000712)3.27143693
53DNA topological change (GO:0006265)3.25525423
54regulation of mitotic spindle organization (GO:0060236)3.22794474
55regulation of translational elongation (GO:0006448)3.22670418
56energy coupled proton transport, down electrochemical gradient (GO:0015985)3.20366727
57ATP synthesis coupled proton transport (GO:0015986)3.20366727
58nucleobase biosynthetic process (GO:0046112)3.18539888
59gas transport (GO:0015669)3.13598882
60mitotic recombination (GO:0006312)3.13381619
61rRNA modification (GO:0000154)3.13113634
62SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.12765106
63telomere maintenance via recombination (GO:0000722)3.12099307
64synapsis (GO:0007129)3.11516395
65rRNA methylation (GO:0031167)3.10995546
66aerobic respiration (GO:0009060)3.10679697
67regulation of histone H3-K4 methylation (GO:0051569)3.10006209
68meiotic chromosome segregation (GO:0045132)3.09014072
69IMP biosynthetic process (GO:0006188)3.04556588
70cotranslational protein targeting to membrane (GO:0006613)3.03062247
71mitotic metaphase plate congression (GO:0007080)3.02876267
72protoporphyrinogen IX biosynthetic process (GO:0006782)3.02655017
73ribosomal small subunit assembly (GO:0000028)3.02591802
74protein targeting to ER (GO:0045047)3.00699049
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98510107
76tricarboxylic acid cycle (GO:0006099)2.97399331
77chromosome segregation (GO:0007059)2.96888770
78oxygen transport (GO:0015671)2.93671642
79transcription from mitochondrial promoter (GO:0006390)2.92851782
80rRNA processing (GO:0006364)2.92730430
81translational elongation (GO:0006414)2.91542575
82establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90994076
83melanin biosynthetic process (GO:0042438)2.90696129
84protein localization to endoplasmic reticulum (GO:0070972)2.89760128
85cellular component biogenesis (GO:0044085)2.88080148
86translation (GO:0006412)2.86682579
87nuclear envelope organization (GO:0006998)2.85390341
88regulation of nucleobase-containing compound transport (GO:0032239)2.82540856
89rRNA metabolic process (GO:0016072)2.78679682
90tetrahydrofolate metabolic process (GO:0046653)2.75982041
91folic acid metabolic process (GO:0046655)2.73520325
92mitochondrial RNA metabolic process (GO:0000959)2.73431605
93cellular protein complex disassembly (GO:0043624)2.72220863
94pseudouridine synthesis (GO:0001522)2.70075662
95protein export from nucleus (GO:0006611)2.68935435
96purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.68604358
97purine nucleoside monophosphate biosynthetic process (GO:0009127)2.68604358
98protein targeting to mitochondrion (GO:0006626)2.67076709
99regulation of centriole replication (GO:0046599)2.65933292
100IMP metabolic process (GO:0046040)2.64362111

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.53389310
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.77047679
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.71135517
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.43211761
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.38456082
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.04682285
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92931658
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83365840
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80454300
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79379426
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.75125528
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73746693
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.58384379
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57376357
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57012968
16XRN2_22483619_ChIP-Seq_HELA_Human2.52640261
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.50432833
18ZNF263_19887448_ChIP-Seq_K562_Human2.38742779
19DCP1A_22483619_ChIP-Seq_HELA_Human2.26925419
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26288115
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.22723804
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.21705476
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17432744
24TTF2_22483619_ChIP-Seq_HELA_Human2.06896503
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04752909
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97853663
27NCOR1_26117541_ChIP-Seq_K562_Human1.86699742
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83735983
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82331995
30KDM5A_27292631_Chip-Seq_BREAST_Human1.81349230
31YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78743815
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76678023
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.74385522
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72717193
35GABP_19822575_ChIP-Seq_HepG2_Human1.70554000
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65207713
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65172589
38AR_21909140_ChIP-Seq_LNCAP_Human1.65014924
39FOXP3_21729870_ChIP-Seq_TREG_Human1.64150187
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60904535
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.58109600
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.54615866
43ELK1_19687146_ChIP-ChIP_HELA_Human1.52608632
44PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52476195
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51723077
46VDR_23849224_ChIP-Seq_CD4+_Human1.48878340
47TFEB_21752829_ChIP-Seq_HELA_Human1.48385551
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45951568
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45900589
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45185430
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44553932
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44014529
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42543192
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40407726
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37749246
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37708734
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35978722
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35150517
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34900809
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32128515
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31781274
62MYC_22102868_ChIP-Seq_BL_Human1.30074315
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30011882
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29187810
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28656863
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28377182
67CIITA_25753668_ChIP-Seq_RAJI_Human1.27228995
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27162896
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20191507
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19752197
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18613688
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16970530
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16207578
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15908839
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13217183
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09329431
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09136851
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06470155
79GATA1_19941826_ChIP-Seq_K562_Human1.05690928
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05355938
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03472368
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98310320
83CHD1_26751641_Chip-Seq_LNCaP_Human0.98080536
84ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97778351
85* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97511630
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96324949
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95616568
88TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93473728
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92785703
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92376924
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90966594
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88916781
93GATA1_22025678_ChIP-Seq_K562_Human0.88496557
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88022671
95RACK7_27058665_Chip-Seq_MCF-7_Human0.86870672
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85230408
97ELK3_25401928_ChIP-Seq_HUVEC_Human0.82963865
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81948835
99GATA6_21074721_ChIP-Seq_CACO-2_Human0.81374417
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.80476759

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog3.96733236
2MP0003693_abnormal_embryo_hatching3.75516289
3MP0003111_abnormal_nucleus_morphology3.57098775
4MP0005171_absent_coat_pigmentation3.45508138
5MP0008058_abnormal_DNA_repair3.40872513
6MP0010094_abnormal_chromosome_stability3.40055616
7MP0005451_abnormal_body_composition3.31165558
8MP0004147_increased_porphyrin_level3.16460977
9MP0005408_hypopigmentation3.03290594
10MP0008961_abnormal_basal_metabolism2.93631157
11MP0000372_irregular_coat_pigmentation2.83072340
12MP0005083_abnormal_biliary_tract2.79881408
13MP0003077_abnormal_cell_cycle2.71208144
14MP0008932_abnormal_embryonic_tissue2.68548310
15MP0008995_early_reproductive_senescence2.66449951
16MP0003959_abnormal_lean_body2.45562245
17MP0003786_premature_aging2.36709543
18MP0008057_abnormal_DNA_replication2.28738722
19MP0004233_abnormal_muscle_weight2.25088373
20MP0003806_abnormal_nucleotide_metabolis2.21442760
21MP0008007_abnormal_cellular_replicative2.09762949
22MP0003186_abnormal_redox_activity2.06727737
23MP0009697_abnormal_copulation2.05257500
24MP0003718_maternal_effect1.84589635
25MP0001730_embryonic_growth_arrest1.80188231
26MP0000678_abnormal_parathyroid_gland1.79326756
27MP0006035_abnormal_mitochondrial_morpho1.79091562
28MP0001881_abnormal_mammary_gland1.76285188
29MP0003136_yellow_coat_color1.66900634
30MP0006036_abnormal_mitochondrial_physio1.66301924
31MP0000350_abnormal_cell_proliferation1.65389287
32MP0003656_abnormal_erythrocyte_physiolo1.52049952
33MP0001697_abnormal_embryo_size1.48663195
34MP0001502_abnormal_circadian_rhythm1.48442019
35MP0002080_prenatal_lethality1.47510465
36MP0000358_abnormal_cell_content/1.47342514
37MP0001661_extended_life_span1.46964705
38MP0001672_abnormal_embryogenesis/_devel1.41572242
39MP0005380_embryogenesis_phenotype1.41572242
40MP0008438_abnormal_cutaneous_collagen1.39331972
41MP0002210_abnormal_sex_determination1.38019048
42MP0003984_embryonic_growth_retardation1.34035792
43MP0000313_abnormal_cell_death1.33135197
44MP0002088_abnormal_embryonic_growth/wei1.28702374
45MP0005058_abnormal_lysosome_morphology1.19621550
46MP0002132_abnormal_respiratory_system1.18672556
47MP0002086_abnormal_extraembryonic_tissu1.18203917
48MP0002877_abnormal_melanocyte_morpholog1.17902884
49MP0002396_abnormal_hematopoietic_system1.15840760
50MP0001929_abnormal_gametogenesis1.14736607
51MP0001764_abnormal_homeostasis1.13342753
52MP0002095_abnormal_skin_pigmentation1.13129941
53MP0002970_abnormal_white_adipose1.07486519
54MP0001348_abnormal_lacrimal_gland1.05112742
55MP0005266_abnormal_metabolism1.01398585
56MP0010307_abnormal_tumor_latency0.98164301
57MP0000015_abnormal_ear_pigmentation0.96226209
58MP0003699_abnormal_female_reproductive0.95862103
59MP0001145_abnormal_male_reproductive0.94244450
60MP0000003_abnormal_adipose_tissue0.94210940
61MP0000371_diluted_coat_color0.94161087
62MP0003123_paternal_imprinting0.93660866
63MP0002075_abnormal_coat/hair_pigmentati0.92635450
64MP0005636_abnormal_mineral_homeostasis0.91902537
65MP0004381_abnormal_hair_follicle0.88590119
66MP0003698_abnormal_male_reproductive0.86424445
67MP0002085_abnormal_embryonic_tissue0.86121236
68MP0000653_abnormal_sex_gland0.84453873
69MP0004808_abnormal_hematopoietic_stem0.84362435
70MP0002269_muscular_atrophy0.82692325
71MP0001186_pigmentation_phenotype0.82568399
72MP0004272_abnormal_basement_membrane0.81490573
73MP0004145_abnormal_muscle_electrophysio0.80748920
74MP0009333_abnormal_splenocyte_physiolog0.80539783
75MP0005645_abnormal_hypothalamus_physiol0.80518467
76MP0002938_white_spotting0.78457811
77MP0001545_abnormal_hematopoietic_system0.78244561
78MP0005397_hematopoietic_system_phenotyp0.78244561
79MP0002019_abnormal_tumor_incidence0.77967480
80MP0001727_abnormal_embryo_implantation0.77957772
81MP0002084_abnormal_developmental_patter0.77915245
82MP0005410_abnormal_fertilization0.77716524
83MP0002161_abnormal_fertility/fecundity0.77658880
84MP0003705_abnormal_hypodermis_morpholog0.76883972
85MP0008770_decreased_survivor_rate0.76087532
86MP0000609_abnormal_liver_physiology0.75918476
87MP0004084_abnormal_cardiac_muscle0.74802206
88MP0005334_abnormal_fat_pad0.74783043
89MP0009931_abnormal_skin_appearance0.74105661
90MP0005501_abnormal_skin_physiology0.73891517
91MP0008775_abnormal_heart_ventricle0.73722794
92MP0005384_cellular_phenotype0.73020248
93MP0010234_abnormal_vibrissa_follicle0.72141438
94MP0004185_abnormal_adipocyte_glucose0.72018919
95MP0009672_abnormal_birth_weight0.71221743
96MP0009840_abnormal_foam_cell0.70861972
97MP0000747_muscle_weakness0.70391109
98MP0005330_cardiomyopathy0.69305766
99MP0004264_abnormal_extraembryonic_tissu0.67031942
100MP0003221_abnormal_cardiomyocyte_apopto0.66962753

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)6.23123936
2Cholecystitis (HP:0001082)6.23123936
3Reticulocytosis (HP:0001923)4.21642314
4Truncus arteriosus (HP:0001660)4.20137223
5Abnormality of reticulocytes (HP:0004312)4.00917203
6Birth length less than 3rd percentile (HP:0003561)3.86676389
7Hyperthyroidism (HP:0000836)3.68932751
8Reticulocytopenia (HP:0001896)3.57164189
9Abnormality of glycolysis (HP:0004366)3.44062477
10Abnormal hemoglobin (HP:0011902)3.42921215
11Upper limb muscle weakness (HP:0003484)3.38039535
12Ileus (HP:0002595)3.33475103
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.33380312
14Cerebral hypomyelination (HP:0006808)3.30979273
15Polycythemia (HP:0001901)3.30883321
16Aplasia/Hypoplasia of the fovea (HP:0008060)3.27849168
17Hypoplasia of the fovea (HP:0007750)3.27849168
18Chromsome breakage (HP:0040012)3.27755317
19Spastic paraparesis (HP:0002313)3.24693910
20Pallor (HP:0000980)3.18122537
21Abnormality of the heme biosynthetic pathway (HP:0010472)3.12134702
22Ankyloglossia (HP:0010296)3.08162327
23Cholelithiasis (HP:0001081)3.07546097
24Increased serum pyruvate (HP:0003542)3.04105919
25Seborrheic dermatitis (HP:0001051)2.96589098
26Abnormality of the tricuspid valve (HP:0001702)2.79602623
27Abnormality of cells of the erythroid lineage (HP:0012130)2.78391159
28Homocystinuria (HP:0002156)2.78085173
29Abnormality of homocysteine metabolism (HP:0010919)2.78085173
30Bowel incontinence (HP:0002607)2.73715237
31Morphological abnormality of the inner ear (HP:0011390)2.71857919
32Aplasia/Hypoplasia of the macula (HP:0008059)2.69680374
33Abnormality of the fovea (HP:0000493)2.68392600
34Hypertensive crisis (HP:0100735)2.67779483
35Nonimmune hydrops fetalis (HP:0001790)2.67291402
36Abnormal large intestine physiology (HP:0012700)2.66289203
37Abnormal gallbladder morphology (HP:0012437)2.65074692
38Acute encephalopathy (HP:0006846)2.63956113
39Abnormal mitochondria in muscle tissue (HP:0008316)2.61075305
40Hypoparathyroidism (HP:0000829)2.55571639
41Aplasia/Hypoplasia affecting the retina (HP:0008061)2.53478374
42Patchy hypopigmentation of hair (HP:0011365)2.52056608
43White forelock (HP:0002211)2.50331602
44Cerebral edema (HP:0002181)2.50304457
45Microvesicular hepatic steatosis (HP:0001414)2.46351019
46Acute necrotizing encephalopathy (HP:0006965)2.45671975
47Macrocytic anemia (HP:0001972)2.44361899
48Abnormal number of erythroid precursors (HP:0012131)2.43197036
49Cortical dysplasia (HP:0002539)2.38664130
50Progressive muscle weakness (HP:0003323)2.34189218
51Abnormality of cochlea (HP:0000375)2.31125575
52CNS hypomyelination (HP:0003429)2.22044366
53Abnormality of sulfur amino acid metabolism (HP:0004339)2.21441038
54Premature ovarian failure (HP:0008209)2.16458204
55Increased CSF lactate (HP:0002490)2.16261215
56Abnormality of the preputium (HP:0100587)2.14413755
57Overlapping toe (HP:0001845)2.14004358
58Breech presentation (HP:0001623)2.13992014
59Atelectasis (HP:0100750)2.12537403
60Duplicated collecting system (HP:0000081)2.12131476
61Abnormality of oral frenula (HP:0000190)2.10092266
62Respiratory difficulties (HP:0002880)2.09951806
63Tinnitus (HP:0000360)2.09846398
64Abnormality of the gallbladder (HP:0005264)2.09619566
65Redundant skin (HP:0001582)2.08153398
66Peripheral hypomyelination (HP:0007182)2.07612653
67Hypokinesia (HP:0002375)2.06784112
68Hyperbilirubinemia (HP:0002904)2.06061339
69Breast hypoplasia (HP:0003187)2.05996214
70Abnormality of alanine metabolism (HP:0010916)2.05266477
71Hyperalaninemia (HP:0003348)2.05266477
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05266477
73Paraparesis (HP:0002385)2.04140436
74Increased serum lactate (HP:0002151)2.02436184
75Sparse lateral eyebrow (HP:0005338)1.98631203
76Secondary amenorrhea (HP:0000869)1.98359017
77Abnormality of DNA repair (HP:0003254)1.98091690
78Poikilocytosis (HP:0004447)1.93873628
79Fatigue (HP:0012378)1.93344216
80Abnormality of methionine metabolism (HP:0010901)1.92550494
81Ureteral duplication (HP:0000073)1.92548908
82Insomnia (HP:0100785)1.92540467
83Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92513930
84Short middle phalanx of the 5th finger (HP:0004220)1.89636643
85Abnormally folded helix (HP:0008544)1.89534049
86Esophageal neoplasm (HP:0100751)1.88660771
87Neoplasm of head and neck (HP:0012288)1.88660771
88Increased hepatocellular lipid droplets (HP:0006565)1.87699558
89Orthostatic hypotension (HP:0001278)1.86486190
90Abnormality of pyrimidine metabolism (HP:0004353)1.83026809
91Acute myeloid leukemia (HP:0004808)1.82865707
92Progressive macrocephaly (HP:0004481)1.82860666
93Entropion (HP:0000621)1.81779821
94Aplasia/Hypoplasia of the thymus (HP:0010515)1.79802373
95Myelodysplasia (HP:0002863)1.79798414
96Hand muscle atrophy (HP:0009130)1.79570699
97Hyperammonemia (HP:0001987)1.78148123
98Patellar dislocation (HP:0002999)1.75667033
99Renal Fanconi syndrome (HP:0001994)1.75609833
100Increased intramyocellular lipid droplets (HP:0012240)1.73861157

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK25.09520868
2EIF2AK14.12586747
3PBK3.63681134
4NME23.23883697
5NEK13.19645726
6TTK2.94826009
7RIPK42.37465397
8EEF2K2.36234454
9ICK2.35136612
10WEE12.18722666
11KSR22.18004585
12BUB12.16400461
13SIK32.12892225
14CDC72.12515403
15SRPK12.03510870
16CCNB12.03341319
17CLK11.92981949
18WNK41.80173316
19NME11.76793504
20EIF2AK31.71807638
21TSSK61.67044978
22RPS6KB21.64040427
23IRAK31.61949816
24BRSK21.57511411
25BMPR21.57162731
26RAF11.55518326
27STK161.54510682
28KSR11.48147651
29MST41.47680332
30MST1R1.46991285
31MAP3K81.44606274
32CHEK21.43240984
33TRIM281.41908418
34BRSK11.37022581
35MAP3K21.35431564
36NEK21.34254766
37SCYL21.30076916
38PLK41.23206863
39TRIB31.19890668
40MAPKAPK31.11393098
41BMX1.06353472
42CHEK11.01522104
43NTRK31.00668576
44ATR0.97578391
45CDK120.96521998
46BRAF0.93135647
47CDK70.91441161
48ALK0.89986918
49PLK10.84699143
50PRKD30.82526185
51ILK0.81355583
52STK40.80933831
53LATS20.79380928
54MARK30.78072455
55PAK40.74967422
56PLK30.74500765
57PAK10.74334634
58AURKB0.73456435
59CDK20.72503584
60CDK10.72154707
61ERN10.66657454
62MTOR0.64554611
63MAP3K30.59432464
64ATM0.59031202
65DMPK0.58029509
66CSNK2A20.57463828
67NEK60.54201522
68CSNK1E0.53874099
69MET0.53464932
70LRRK20.52809788
71MAP3K10.52579798
72CDK80.51947122
73PKN20.51491581
74CDK40.51299773
75PRPF4B0.49768831
76AURKA0.47572489
77PIM10.47117923
78TAOK20.44800803
79MAP2K10.44399988
80CSNK2A10.42063511
81STK30.40975363
82AKT30.39906797
83STK100.39428110
84AKT20.39375513
85MAP3K60.38297551
86PIK3CG0.37382090
87MKNK10.35160406
88ZAK0.34662576
89CDK30.33173503
90JAK30.32958968
91MAPKAPK50.31958016
92MAPK140.31645500
93PRKG20.31579752
94GSK3B0.30638580
95VRK20.29726675
96CDK11A0.28996057
97BRD40.28309702
98AKT10.26754199
99CDK180.26148754
100MAPK110.25423867

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.34029857
2DNA replication_Homo sapiens_hsa030303.67481315
3Ribosome_Homo sapiens_hsa030103.32603687
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.24399038
5Mismatch repair_Homo sapiens_hsa034303.20593920
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.17433782
7One carbon pool by folate_Homo sapiens_hsa006702.56079817
8RNA transport_Homo sapiens_hsa030132.44578631
9Homologous recombination_Homo sapiens_hsa034402.44193486
10Spliceosome_Homo sapiens_hsa030402.41415161
11Biosynthesis of amino acids_Homo sapiens_hsa012302.26281982
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.21923758
13RNA polymerase_Homo sapiens_hsa030202.20243195
14Proteasome_Homo sapiens_hsa030502.18787706
15Nucleotide excision repair_Homo sapiens_hsa034202.12423865
16Carbon metabolism_Homo sapiens_hsa012001.90533580
17Parkinsons disease_Homo sapiens_hsa050121.86246427
18Cell cycle_Homo sapiens_hsa041101.86013037
19Oxidative phosphorylation_Homo sapiens_hsa001901.85111010
20Fanconi anemia pathway_Homo sapiens_hsa034601.80065268
21Pyruvate metabolism_Homo sapiens_hsa006201.77942804
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73484563
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.66263855
24Base excision repair_Homo sapiens_hsa034101.64080086
25Arginine biosynthesis_Homo sapiens_hsa002201.63768552
26Pyrimidine metabolism_Homo sapiens_hsa002401.56814184
27Basal transcription factors_Homo sapiens_hsa030221.54900321
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.53842634
29Fructose and mannose metabolism_Homo sapiens_hsa000511.53108164
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51236613
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.46784732
32Huntingtons disease_Homo sapiens_hsa050161.42957445
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40446083
34Pentose phosphate pathway_Homo sapiens_hsa000301.39056744
35mRNA surveillance pathway_Homo sapiens_hsa030151.30497049
36Non-homologous end-joining_Homo sapiens_hsa034501.29230823
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22031627
38Purine metabolism_Homo sapiens_hsa002301.15955079
39Alzheimers disease_Homo sapiens_hsa050101.12229934
40N-Glycan biosynthesis_Homo sapiens_hsa005101.10136169
41RNA degradation_Homo sapiens_hsa030181.06283512
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03080586
43Sulfur relay system_Homo sapiens_hsa041221.00951664
44Protein export_Homo sapiens_hsa030601.00275562
45Selenocompound metabolism_Homo sapiens_hsa004500.99633891
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97390765
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93127666
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85558310
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79846485
50Tyrosine metabolism_Homo sapiens_hsa003500.76264349
51Steroid biosynthesis_Homo sapiens_hsa001000.75891381
52Other glycan degradation_Homo sapiens_hsa005110.72312204
53Fatty acid elongation_Homo sapiens_hsa000620.71280826
54Oocyte meiosis_Homo sapiens_hsa041140.67262605
55Thyroid cancer_Homo sapiens_hsa052160.66964487
56Galactose metabolism_Homo sapiens_hsa000520.65946746
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.65172460
58Viral carcinogenesis_Homo sapiens_hsa052030.64197733
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61083041
60Metabolic pathways_Homo sapiens_hsa011000.60719652
61Acute myeloid leukemia_Homo sapiens_hsa052210.59680710
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58359161
63Propanoate metabolism_Homo sapiens_hsa006400.56325715
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55875802
65Folate biosynthesis_Homo sapiens_hsa007900.54566681
66Epstein-Barr virus infection_Homo sapiens_hsa051690.54259063
67Chronic myeloid leukemia_Homo sapiens_hsa052200.54205534
68HIF-1 signaling pathway_Homo sapiens_hsa040660.52758064
69Glutathione metabolism_Homo sapiens_hsa004800.52207071
70Prion diseases_Homo sapiens_hsa050200.50036837
71Vitamin B6 metabolism_Homo sapiens_hsa007500.46324591
72Lysine degradation_Homo sapiens_hsa003100.46146226
73Arginine and proline metabolism_Homo sapiens_hsa003300.43200930
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.42363080
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41653655
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.40142935
77mTOR signaling pathway_Homo sapiens_hsa041500.39177792
78Fatty acid metabolism_Homo sapiens_hsa012120.38388759
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38283800
80Cardiac muscle contraction_Homo sapiens_hsa042600.37308523
81Phenylalanine metabolism_Homo sapiens_hsa003600.36628736
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35074662
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34580589
84VEGF signaling pathway_Homo sapiens_hsa043700.33906361
85Pancreatic cancer_Homo sapiens_hsa052120.30570781
86ErbB signaling pathway_Homo sapiens_hsa040120.28831966
87Insulin signaling pathway_Homo sapiens_hsa049100.27375345
88Nitrogen metabolism_Homo sapiens_hsa009100.26696690
89Vibrio cholerae infection_Homo sapiens_hsa051100.26418826
90Non-small cell lung cancer_Homo sapiens_hsa052230.24899425
91Bladder cancer_Homo sapiens_hsa052190.23438533
92Renal cell carcinoma_Homo sapiens_hsa052110.23332877
93Olfactory transduction_Homo sapiens_hsa047400.21776761
94MicroRNAs in cancer_Homo sapiens_hsa052060.17890844
95p53 signaling pathway_Homo sapiens_hsa041150.16732963
96Fatty acid biosynthesis_Homo sapiens_hsa000610.14505039
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.07804030
98Small cell lung cancer_Homo sapiens_hsa052220.07400146
99HTLV-I infection_Homo sapiens_hsa051660.06811237
100Sulfur metabolism_Homo sapiens_hsa009200.06417237

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