ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sexual reproduction (GO:0019953)	6.33695491
2	nuclear pore complex assembly (GO:0051292)	5.99945201
3	regulation of translational fidelity (GO:0006450)	5.48636031
4	formation of translation preinitiation complex (GO:0001731)	5.43476082
5	response to dietary excess (GO:0002021)	5.26861369
6	nuclear pore organization (GO:0006999)	5.21412495
7	homocysteine metabolic process (GO:0050667)	4.89990356
8	DNA replication checkpoint (GO:0000076)	4.79674877
9	oxidative phosphorylation (GO:0006119)	4.56667080
10	DNA unwinding involved in DNA replication (GO:0006268)	4.50518654
11	pore complex assembly (GO:0046931)	4.42759123
12	ribosomal large subunit biogenesis (GO:0042273)	4.29680071
13	DNA replication initiation (GO:0006270)	4.27421535
14	tRNA aminoacylation for protein translation (GO:0006418)	4.17596544
15	diterpenoid biosynthetic process (GO:0016102)	4.16151171
16	mitotic nuclear envelope disassembly (GO:0007077)	4.14983733
17	COPI coating of Golgi vesicle (GO:0048205)	4.04730489
18	Golgi transport vesicle coating (GO:0048200)	4.04730489
19	DNA strand elongation involved in DNA replication (GO:0006271)	4.03078945
20	tRNA aminoacylation (GO:0043039)	4.02636895
21	amino acid activation (GO:0043038)	4.02636895
22	mitotic sister chromatid segregation (GO:0000070)	4.01527257
23	DNA strand elongation (GO:0022616)	3.94060996
24	ribonucleoprotein complex biogenesis (GO:0022613)	3.88771349
25	ribosome biogenesis (GO:0042254)	3.86533803
26	ribosomal small subunit biogenesis (GO:0042274)	3.82505867
27	nuclear envelope disassembly (GO:0051081)	3.80499483
28	membrane disassembly (GO:0030397)	3.80499483
29	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.75716079
30	sister chromatid segregation (GO:0000819)	3.68155808
31	proline biosynthetic process (GO:0006561)	3.65417503
32	terpenoid biosynthetic process (GO:0016114)	3.64225636
33	telomere maintenance via semi-conservative replication (GO:0032201)	3.63887369
34	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.60838314
35	ribosome assembly (GO:0042255)	3.58480232
36	regulation of RNA export from nucleus (GO:0046831)	3.54832236
37	midgut development (GO:0007494)	3.53762895
38	mitotic chromosome condensation (GO:0007076)	3.53577208
39	protoporphyrinogen IX metabolic process (GO:0046501)	3.53485965
40	proteasome assembly (GO:0043248)	3.44686957
41	oxaloacetate metabolic process (GO:0006107)	3.44155379
42	maturation of SSU-rRNA (GO:0030490)	3.42335112
43	viral transcription (GO:0019083)	3.39946387
44	maturation of 5.8S rRNA (GO:0000460)	3.35307472
45	purine nucleobase biosynthetic process (GO:0009113)	3.33308955
46	translational termination (GO:0006415)	3.31723806
47	translational initiation (GO:0006413)	3.31295449
48	nucleobase-containing small molecule interconversion (GO:0015949)	3.31068268
49	regulation of histone H3-K27 methylation (GO:0061085)	3.29459693
50	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.29198169
51	folic acid-containing compound biosynthetic process (GO:0009396)	3.28781401
52	resolution of meiotic recombination intermediates (GO:0000712)	3.27143693
53	DNA topological change (GO:0006265)	3.25525423
54	regulation of mitotic spindle organization (GO:0060236)	3.22794474
55	regulation of translational elongation (GO:0006448)	3.22670418
56	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.20366727
57	ATP synthesis coupled proton transport (GO:0015986)	3.20366727
58	nucleobase biosynthetic process (GO:0046112)	3.18539888
59	gas transport (GO:0015669)	3.13598882
60	mitotic recombination (GO:0006312)	3.13381619
61	rRNA modification (GO:0000154)	3.13113634
62	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.12765106
63	telomere maintenance via recombination (GO:0000722)	3.12099307
64	synapsis (GO:0007129)	3.11516395
65	rRNA methylation (GO:0031167)	3.10995546
66	aerobic respiration (GO:0009060)	3.10679697
67	regulation of histone H3-K4 methylation (GO:0051569)	3.10006209
68	meiotic chromosome segregation (GO:0045132)	3.09014072
69	IMP biosynthetic process (GO:0006188)	3.04556588
70	cotranslational protein targeting to membrane (GO:0006613)	3.03062247
71	mitotic metaphase plate congression (GO:0007080)	3.02876267
72	protoporphyrinogen IX biosynthetic process (GO:0006782)	3.02655017
73	ribosomal small subunit assembly (GO:0000028)	3.02591802
74	protein targeting to ER (GO:0045047)	3.00699049
75	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.98510107
76	tricarboxylic acid cycle (GO:0006099)	2.97399331
77	chromosome segregation (GO:0007059)	2.96888770
78	oxygen transport (GO:0015671)	2.93671642
79	transcription from mitochondrial promoter (GO:0006390)	2.92851782
80	rRNA processing (GO:0006364)	2.92730430
81	translational elongation (GO:0006414)	2.91542575
82	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.90994076
83	melanin biosynthetic process (GO:0042438)	2.90696129
84	protein localization to endoplasmic reticulum (GO:0070972)	2.89760128
85	cellular component biogenesis (GO:0044085)	2.88080148
86	translation (GO:0006412)	2.86682579
87	nuclear envelope organization (GO:0006998)	2.85390341
88	regulation of nucleobase-containing compound transport (GO:0032239)	2.82540856
89	rRNA metabolic process (GO:0016072)	2.78679682
90	tetrahydrofolate metabolic process (GO:0046653)	2.75982041
91	folic acid metabolic process (GO:0046655)	2.73520325
92	mitochondrial RNA metabolic process (GO:0000959)	2.73431605
93	cellular protein complex disassembly (GO:0043624)	2.72220863
94	pseudouridine synthesis (GO:0001522)	2.70075662
95	protein export from nucleus (GO:0006611)	2.68935435
96	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.68604358
97	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.68604358
98	protein targeting to mitochondrion (GO:0006626)	2.67076709
99	regulation of centriole replication (GO:0046599)	2.65933292
100	IMP metabolic process (GO:0046040)	2.64362111

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.53389310
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.77047679
3	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.71135517
4	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.43211761
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.38456082
6	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.04682285
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.92931658
8	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.83365840
9	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.80454300
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.79379426
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.75125528
12	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.73746693
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.58384379
14	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.57376357
15	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.57012968
16	XRN2_22483619_ChIP-Seq_HELA_Human	2.52640261
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.50432833
18	ZNF263_19887448_ChIP-Seq_K562_Human	2.38742779
19	DCP1A_22483619_ChIP-Seq_HELA_Human	2.26925419
20	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.26288115
21	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.22723804
22	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.21705476
23	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.17432744
24	TTF2_22483619_ChIP-Seq_HELA_Human	2.06896503
25	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.04752909
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.97853663
27	NCOR1_26117541_ChIP-Seq_K562_Human	1.86699742
28	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.83735983
29	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.82331995
30	KDM5A_27292631_Chip-Seq_BREAST_Human	1.81349230
31	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.78743815
32	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.76678023
33	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.74385522
34	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.72717193
35	GABP_19822575_ChIP-Seq_HepG2_Human	1.70554000
36	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.65207713
37	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.65172589
38	AR_21909140_ChIP-Seq_LNCAP_Human	1.65014924
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.64150187
40	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.60904535
41	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.58109600
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.54615866
43	ELK1_19687146_ChIP-ChIP_HELA_Human	1.52608632
44	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.52476195
45	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.51723077
46	VDR_23849224_ChIP-Seq_CD4+_Human	1.48878340
47	TFEB_21752829_ChIP-Seq_HELA_Human	1.48385551
48	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.45951568
49	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.45900589
50	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.45185430
51	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.44553932
52	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.44014529
53	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.42543192
54	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.40407726
55	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.37749246
56	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.37708734
57	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.35978722
58	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.35150517
59	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.34900809
60	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.32128515
61	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.31781274
62	MYC_22102868_ChIP-Seq_BL_Human	1.30074315
63	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.30011882
64	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.29187810
65	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.28656863
66	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.28377182
67	CIITA_25753668_ChIP-Seq_RAJI_Human	1.27228995
68	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.27162896
69	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.20191507
70	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.19752197
71	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.18613688
72	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.16970530
73	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.16207578
74	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.15908839
75	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.13217183
76	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.09329431
77	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.09136851
78	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.06470155
79	GATA1_19941826_ChIP-Seq_K562_Human	1.05690928
80	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.05355938
81	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.03472368
82	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.98310320
83	CHD1_26751641_Chip-Seq_LNCaP_Human	0.98080536
84	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.97778351
85	* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.97511630
86	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.96324949
87	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.95616568
88	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.93473728
89	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.92785703
90	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.92376924
91	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.90966594
92	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.88916781
93	GATA1_22025678_ChIP-Seq_K562_Human	0.88496557
94	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.88022671
95	RACK7_27058665_Chip-Seq_MCF-7_Human	0.86870672
96	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.85230408
97	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.82963865
98	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.81948835
99	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.81374417
100	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.80476759

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004957_abnormal_blastocyst_morpholog	3.96733236
2	MP0003693_abnormal_embryo_hatching	3.75516289
3	MP0003111_abnormal_nucleus_morphology	3.57098775
4	MP0005171_absent_coat_pigmentation	3.45508138
5	MP0008058_abnormal_DNA_repair	3.40872513
6	MP0010094_abnormal_chromosome_stability	3.40055616
7	MP0005451_abnormal_body_composition	3.31165558
8	MP0004147_increased_porphyrin_level	3.16460977
9	MP0005408_hypopigmentation	3.03290594
10	MP0008961_abnormal_basal_metabolism	2.93631157
11	MP0000372_irregular_coat_pigmentation	2.83072340
12	MP0005083_abnormal_biliary_tract	2.79881408
13	MP0003077_abnormal_cell_cycle	2.71208144
14	MP0008932_abnormal_embryonic_tissue	2.68548310
15	MP0008995_early_reproductive_senescence	2.66449951
16	MP0003959_abnormal_lean_body	2.45562245
17	MP0003786_premature_aging	2.36709543
18	MP0008057_abnormal_DNA_replication	2.28738722
19	MP0004233_abnormal_muscle_weight	2.25088373
20	MP0003806_abnormal_nucleotide_metabolis	2.21442760
21	MP0008007_abnormal_cellular_replicative	2.09762949
22	MP0003186_abnormal_redox_activity	2.06727737
23	MP0009697_abnormal_copulation	2.05257500
24	MP0003718_maternal_effect	1.84589635
25	MP0001730_embryonic_growth_arrest	1.80188231
26	MP0000678_abnormal_parathyroid_gland	1.79326756
27	MP0006035_abnormal_mitochondrial_morpho	1.79091562
28	MP0001881_abnormal_mammary_gland	1.76285188
29	MP0003136_yellow_coat_color	1.66900634
30	MP0006036_abnormal_mitochondrial_physio	1.66301924
31	MP0000350_abnormal_cell_proliferation	1.65389287
32	MP0003656_abnormal_erythrocyte_physiolo	1.52049952
33	MP0001697_abnormal_embryo_size	1.48663195
34	MP0001502_abnormal_circadian_rhythm	1.48442019
35	MP0002080_prenatal_lethality	1.47510465
36	MP0000358_abnormal_cell_content/	1.47342514
37	MP0001661_extended_life_span	1.46964705
38	MP0001672_abnormal_embryogenesis/_devel	1.41572242
39	MP0005380_embryogenesis_phenotype	1.41572242
40	MP0008438_abnormal_cutaneous_collagen	1.39331972
41	MP0002210_abnormal_sex_determination	1.38019048
42	MP0003984_embryonic_growth_retardation	1.34035792
43	MP0000313_abnormal_cell_death	1.33135197
44	MP0002088_abnormal_embryonic_growth/wei	1.28702374
45	MP0005058_abnormal_lysosome_morphology	1.19621550
46	MP0002132_abnormal_respiratory_system	1.18672556
47	MP0002086_abnormal_extraembryonic_tissu	1.18203917
48	MP0002877_abnormal_melanocyte_morpholog	1.17902884
49	MP0002396_abnormal_hematopoietic_system	1.15840760
50	MP0001929_abnormal_gametogenesis	1.14736607
51	MP0001764_abnormal_homeostasis	1.13342753
52	MP0002095_abnormal_skin_pigmentation	1.13129941
53	MP0002970_abnormal_white_adipose	1.07486519
54	MP0001348_abnormal_lacrimal_gland	1.05112742
55	MP0005266_abnormal_metabolism	1.01398585
56	MP0010307_abnormal_tumor_latency	0.98164301
57	MP0000015_abnormal_ear_pigmentation	0.96226209
58	MP0003699_abnormal_female_reproductive	0.95862103
59	MP0001145_abnormal_male_reproductive	0.94244450
60	MP0000003_abnormal_adipose_tissue	0.94210940
61	MP0000371_diluted_coat_color	0.94161087
62	MP0003123_paternal_imprinting	0.93660866
63	MP0002075_abnormal_coat/hair_pigmentati	0.92635450
64	MP0005636_abnormal_mineral_homeostasis	0.91902537
65	MP0004381_abnormal_hair_follicle	0.88590119
66	MP0003698_abnormal_male_reproductive	0.86424445
67	MP0002085_abnormal_embryonic_tissue	0.86121236
68	MP0000653_abnormal_sex_gland	0.84453873
69	MP0004808_abnormal_hematopoietic_stem	0.84362435
70	MP0002269_muscular_atrophy	0.82692325
71	MP0001186_pigmentation_phenotype	0.82568399
72	MP0004272_abnormal_basement_membrane	0.81490573
73	MP0004145_abnormal_muscle_electrophysio	0.80748920
74	MP0009333_abnormal_splenocyte_physiolog	0.80539783
75	MP0005645_abnormal_hypothalamus_physiol	0.80518467
76	MP0002938_white_spotting	0.78457811
77	MP0001545_abnormal_hematopoietic_system	0.78244561
78	MP0005397_hematopoietic_system_phenotyp	0.78244561
79	MP0002019_abnormal_tumor_incidence	0.77967480
80	MP0001727_abnormal_embryo_implantation	0.77957772
81	MP0002084_abnormal_developmental_patter	0.77915245
82	MP0005410_abnormal_fertilization	0.77716524
83	MP0002161_abnormal_fertility/fecundity	0.77658880
84	MP0003705_abnormal_hypodermis_morpholog	0.76883972
85	MP0008770_decreased_survivor_rate	0.76087532
86	MP0000609_abnormal_liver_physiology	0.75918476
87	MP0004084_abnormal_cardiac_muscle	0.74802206
88	MP0005334_abnormal_fat_pad	0.74783043
89	MP0009931_abnormal_skin_appearance	0.74105661
90	MP0005501_abnormal_skin_physiology	0.73891517
91	MP0008775_abnormal_heart_ventricle	0.73722794
92	MP0005384_cellular_phenotype	0.73020248
93	MP0010234_abnormal_vibrissa_follicle	0.72141438
94	MP0004185_abnormal_adipocyte_glucose	0.72018919
95	MP0009672_abnormal_birth_weight	0.71221743
96	MP0009840_abnormal_foam_cell	0.70861972
97	MP0000747_muscle_weakness	0.70391109
98	MP0005330_cardiomyopathy	0.69305766
99	MP0004264_abnormal_extraembryonic_tissu	0.67031942
100	MP0003221_abnormal_cardiomyocyte_apopto	0.66962753

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cholecystitis (HP:0001082)	6.23123936
2	Abnormal gallbladder physiology (HP:0012438)	6.23123936
3	Reticulocytosis (HP:0001923)	4.21642314
4	Truncus arteriosus (HP:0001660)	4.20137223
5	Abnormality of reticulocytes (HP:0004312)	4.00917203
6	Birth length less than 3rd percentile (HP:0003561)	3.86676389
7	Hyperthyroidism (HP:0000836)	3.68932751
8	Reticulocytopenia (HP:0001896)	3.57164189
9	Abnormality of glycolysis (HP:0004366)	3.44062477
10	Abnormal hemoglobin (HP:0011902)	3.42921215
11	Upper limb muscle weakness (HP:0003484)	3.38039535
12	Ileus (HP:0002595)	3.33475103
13	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.33380312
14	Cerebral hypomyelination (HP:0006808)	3.30979273
15	Polycythemia (HP:0001901)	3.30883321
16	Hypoplasia of the fovea (HP:0007750)	3.27849168
17	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.27849168
18	Chromsome breakage (HP:0040012)	3.27755317
19	Spastic paraparesis (HP:0002313)	3.24693910
20	Pallor (HP:0000980)	3.18122537
21	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.12134702
22	Ankyloglossia (HP:0010296)	3.08162327
23	Cholelithiasis (HP:0001081)	3.07546097
24	Increased serum pyruvate (HP:0003542)	3.04105919
25	Seborrheic dermatitis (HP:0001051)	2.96589098
26	Abnormality of the tricuspid valve (HP:0001702)	2.79602623
27	Abnormality of cells of the erythroid lineage (HP:0012130)	2.78391159
28	Abnormality of homocysteine metabolism (HP:0010919)	2.78085173
29	Homocystinuria (HP:0002156)	2.78085173
30	Bowel incontinence (HP:0002607)	2.73715237
31	Morphological abnormality of the inner ear (HP:0011390)	2.71857919
32	Aplasia/Hypoplasia of the macula (HP:0008059)	2.69680374
33	Abnormality of the fovea (HP:0000493)	2.68392600
34	Hypertensive crisis (HP:0100735)	2.67779483
35	Nonimmune hydrops fetalis (HP:0001790)	2.67291402
36	Abnormal large intestine physiology (HP:0012700)	2.66289203
37	Abnormal gallbladder morphology (HP:0012437)	2.65074692
38	Acute encephalopathy (HP:0006846)	2.63956113
39	Abnormal mitochondria in muscle tissue (HP:0008316)	2.61075305
40	Hypoparathyroidism (HP:0000829)	2.55571639
41	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.53478374
42	Patchy hypopigmentation of hair (HP:0011365)	2.52056608
43	White forelock (HP:0002211)	2.50331602
44	Cerebral edema (HP:0002181)	2.50304457
45	Microvesicular hepatic steatosis (HP:0001414)	2.46351019
46	Acute necrotizing encephalopathy (HP:0006965)	2.45671975
47	Macrocytic anemia (HP:0001972)	2.44361899
48	Abnormal number of erythroid precursors (HP:0012131)	2.43197036
49	Cortical dysplasia (HP:0002539)	2.38664130
50	Progressive muscle weakness (HP:0003323)	2.34189218
51	Abnormality of cochlea (HP:0000375)	2.31125575
52	CNS hypomyelination (HP:0003429)	2.22044366
53	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.21441038
54	Premature ovarian failure (HP:0008209)	2.16458204
55	Increased CSF lactate (HP:0002490)	2.16261215
56	Abnormality of the preputium (HP:0100587)	2.14413755
57	Overlapping toe (HP:0001845)	2.14004358
58	Breech presentation (HP:0001623)	2.13992014
59	Atelectasis (HP:0100750)	2.12537403
60	Duplicated collecting system (HP:0000081)	2.12131476
61	Abnormality of oral frenula (HP:0000190)	2.10092266
62	Respiratory difficulties (HP:0002880)	2.09951806
63	Tinnitus (HP:0000360)	2.09846398
64	Abnormality of the gallbladder (HP:0005264)	2.09619566
65	Redundant skin (HP:0001582)	2.08153398
66	Peripheral hypomyelination (HP:0007182)	2.07612653
67	Hypokinesia (HP:0002375)	2.06784112
68	Hyperbilirubinemia (HP:0002904)	2.06061339
69	Breast hypoplasia (HP:0003187)	2.05996214
70	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.05266477
71	Abnormality of alanine metabolism (HP:0010916)	2.05266477
72	Hyperalaninemia (HP:0003348)	2.05266477
73	Paraparesis (HP:0002385)	2.04140436
74	Increased serum lactate (HP:0002151)	2.02436184
75	Sparse lateral eyebrow (HP:0005338)	1.98631203
76	Secondary amenorrhea (HP:0000869)	1.98359017
77	Abnormality of DNA repair (HP:0003254)	1.98091690
78	Poikilocytosis (HP:0004447)	1.93873628
79	Fatigue (HP:0012378)	1.93344216
80	Abnormality of methionine metabolism (HP:0010901)	1.92550494
81	Ureteral duplication (HP:0000073)	1.92548908
82	Insomnia (HP:0100785)	1.92540467
83	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.92513930
84	Short middle phalanx of the 5th finger (HP:0004220)	1.89636643
85	Abnormally folded helix (HP:0008544)	1.89534049
86	Neoplasm of head and neck (HP:0012288)	1.88660771
87	Esophageal neoplasm (HP:0100751)	1.88660771
88	Increased hepatocellular lipid droplets (HP:0006565)	1.87699558
89	Orthostatic hypotension (HP:0001278)	1.86486190
90	Abnormality of pyrimidine metabolism (HP:0004353)	1.83026809
91	Acute myeloid leukemia (HP:0004808)	1.82865707
92	Progressive macrocephaly (HP:0004481)	1.82860666
93	Entropion (HP:0000621)	1.81779821
94	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.79802373
95	Myelodysplasia (HP:0002863)	1.79798414
96	Hand muscle atrophy (HP:0009130)	1.79570699
97	Hyperammonemia (HP:0001987)	1.78148123
98	Patellar dislocation (HP:0002999)	1.75667033
99	Renal Fanconi syndrome (HP:0001994)	1.75609833
100	Increased intramyocellular lipid droplets (HP:0012240)	1.73861157

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	5.09520868
2	EIF2AK1	4.12586747
3	PBK	3.63681134
4	NME2	3.23883697
5	NEK1	3.19645726
6	TTK	2.94826009
7	RIPK4	2.37465397
8	EEF2K	2.36234454
9	ICK	2.35136612
10	WEE1	2.18722666
11	KSR2	2.18004585
12	BUB1	2.16400461
13	SIK3	2.12892225
14	CDC7	2.12515403
15	SRPK1	2.03510870
16	CCNB1	2.03341319
17	CLK1	1.92981949
18	WNK4	1.80173316
19	NME1	1.76793504
20	EIF2AK3	1.71807638
21	TSSK6	1.67044978
22	RPS6KB2	1.64040427
23	IRAK3	1.61949816
24	BRSK2	1.57511411
25	BMPR2	1.57162731
26	RAF1	1.55518326
27	STK16	1.54510682
28	KSR1	1.48147651
29	MST4	1.47680332
30	MST1R	1.46991285
31	MAP3K8	1.44606274
32	CHEK2	1.43240984
33	TRIM28	1.41908418
34	BRSK1	1.37022581
35	MAP3K2	1.35431564
36	NEK2	1.34254766
37	SCYL2	1.30076916
38	PLK4	1.23206863
39	TRIB3	1.19890668
40	MAPKAPK3	1.11393098
41	BMX	1.06353472
42	CHEK1	1.01522104
43	NTRK3	1.00668576
44	ATR	0.97578391
45	CDK12	0.96521998
46	BRAF	0.93135647
47	CDK7	0.91441161
48	ALK	0.89986918
49	PLK1	0.84699143
50	PRKD3	0.82526185
51	ILK	0.81355583
52	STK4	0.80933831
53	LATS2	0.79380928
54	MARK3	0.78072455
55	PAK4	0.74967422
56	PLK3	0.74500765
57	PAK1	0.74334634
58	AURKB	0.73456435
59	CDK2	0.72503584
60	CDK1	0.72154707
61	ERN1	0.66657454
62	MTOR	0.64554611
63	MAP3K3	0.59432464
64	ATM	0.59031202
65	DMPK	0.58029509
66	CSNK2A2	0.57463828
67	NEK6	0.54201522
68	CSNK1E	0.53874099
69	MET	0.53464932
70	LRRK2	0.52809788
71	MAP3K1	0.52579798
72	CDK8	0.51947122
73	PKN2	0.51491581
74	CDK4	0.51299773
75	PRPF4B	0.49768831
76	AURKA	0.47572489
77	PIM1	0.47117923
78	TAOK2	0.44800803
79	MAP2K1	0.44399988
80	CSNK2A1	0.42063511
81	STK3	0.40975363
82	AKT3	0.39906797
83	STK10	0.39428110
84	AKT2	0.39375513
85	MAP3K6	0.38297551
86	PIK3CG	0.37382090
87	MKNK1	0.35160406
88	ZAK	0.34662576
89	CDK3	0.33173503
90	JAK3	0.32958968
91	MAPKAPK5	0.31958016
92	MAPK14	0.31645500
93	PRKG2	0.31579752
94	GSK3B	0.30638580
95	VRK2	0.29726675
96	CDK11A	0.28996057
97	BRD4	0.28309702
98	AKT1	0.26754199
99	CDK18	0.26148754
100	MAPK11	0.25423867

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	4.34029857
2	DNA replication_Homo sapiens_hsa03030	3.67481315
3	Ribosome_Homo sapiens_hsa03010	3.32603687
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.24399038
5	Mismatch repair_Homo sapiens_hsa03430	3.20593920
6	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.17433782
7	One carbon pool by folate_Homo sapiens_hsa00670	2.56079817
8	RNA transport_Homo sapiens_hsa03013	2.44578631
9	Homologous recombination_Homo sapiens_hsa03440	2.44193486
10	Spliceosome_Homo sapiens_hsa03040	2.41415161
11	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.26281982
12	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.21923758
13	RNA polymerase_Homo sapiens_hsa03020	2.20243195
14	Proteasome_Homo sapiens_hsa03050	2.18787706
15	Nucleotide excision repair_Homo sapiens_hsa03420	2.12423865
16	Carbon metabolism_Homo sapiens_hsa01200	1.90533580
17	Parkinsons disease_Homo sapiens_hsa05012	1.86246427
18	Cell cycle_Homo sapiens_hsa04110	1.86013037
19	Oxidative phosphorylation_Homo sapiens_hsa00190	1.85111010
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.80065268
21	Pyruvate metabolism_Homo sapiens_hsa00620	1.77942804
22	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.73484563
23	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.66263855
24	Base excision repair_Homo sapiens_hsa03410	1.64080086
25	Arginine biosynthesis_Homo sapiens_hsa00220	1.63768552
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.56814184
27	Basal transcription factors_Homo sapiens_hsa03022	1.54900321
28	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.53842634
29	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.53108164
30	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.51236613
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.46784732
32	Huntingtons disease_Homo sapiens_hsa05016	1.42957445
33	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.40446083
34	Pentose phosphate pathway_Homo sapiens_hsa00030	1.39056744
35	mRNA surveillance pathway_Homo sapiens_hsa03015	1.30497049
36	Non-homologous end-joining_Homo sapiens_hsa03450	1.29230823
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.22031627
38	Purine metabolism_Homo sapiens_hsa00230	1.15955079
39	Alzheimers disease_Homo sapiens_hsa05010	1.12229934
40	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.10136169
41	RNA degradation_Homo sapiens_hsa03018	1.06283512
42	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.03080586
43	Sulfur relay system_Homo sapiens_hsa04122	1.00951664
44	Protein export_Homo sapiens_hsa03060	1.00275562
45	Selenocompound metabolism_Homo sapiens_hsa00450	0.99633891
46	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.97390765
47	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.93127666
48	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.85558310
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.79846485
50	Tyrosine metabolism_Homo sapiens_hsa00350	0.76264349
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.75891381
52	Other glycan degradation_Homo sapiens_hsa00511	0.72312204
53	Fatty acid elongation_Homo sapiens_hsa00062	0.71280826
54	Oocyte meiosis_Homo sapiens_hsa04114	0.67262605
55	Thyroid cancer_Homo sapiens_hsa05216	0.66964487
56	Galactose metabolism_Homo sapiens_hsa00052	0.65946746
57	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.65172460
58	Viral carcinogenesis_Homo sapiens_hsa05203	0.64197733
59	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.61083041
60	Metabolic pathways_Homo sapiens_hsa01100	0.60719652
61	Acute myeloid leukemia_Homo sapiens_hsa05221	0.59680710
62	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.58359161
63	Propanoate metabolism_Homo sapiens_hsa00640	0.56325715
64	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.55875802
65	Folate biosynthesis_Homo sapiens_hsa00790	0.54566681
66	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.54259063
67	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.54205534
68	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.52758064
69	Glutathione metabolism_Homo sapiens_hsa00480	0.52207071
70	Prion diseases_Homo sapiens_hsa05020	0.50036837
71	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.46324591
72	Lysine degradation_Homo sapiens_hsa00310	0.46146226
73	Arginine and proline metabolism_Homo sapiens_hsa00330	0.43200930
74	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42363080
75	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.41653655
76	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.40142935
77	mTOR signaling pathway_Homo sapiens_hsa04150	0.39177792
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.38388759
79	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38283800
80	Cardiac muscle contraction_Homo sapiens_hsa04260	0.37308523
81	Phenylalanine metabolism_Homo sapiens_hsa00360	0.36628736
82	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.35074662
83	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.34580589
84	VEGF signaling pathway_Homo sapiens_hsa04370	0.33906361
85	Pancreatic cancer_Homo sapiens_hsa05212	0.30570781
86	ErbB signaling pathway_Homo sapiens_hsa04012	0.28831966
87	Insulin signaling pathway_Homo sapiens_hsa04910	0.27375345
88	Nitrogen metabolism_Homo sapiens_hsa00910	0.26696690
89	Vibrio cholerae infection_Homo sapiens_hsa05110	0.26418826
90	Non-small cell lung cancer_Homo sapiens_hsa05223	0.24899425
91	Bladder cancer_Homo sapiens_hsa05219	0.23438533
92	Renal cell carcinoma_Homo sapiens_hsa05211	0.23332877
93	Olfactory transduction_Homo sapiens_hsa04740	0.21776761
94	MicroRNAs in cancer_Homo sapiens_hsa05206	0.17890844
95	p53 signaling pathway_Homo sapiens_hsa04115	0.16732963
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.14505039
97	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.07804030
98	Small cell lung cancer_Homo sapiens_hsa05222	0.07400146
99	HTLV-I infection_Homo sapiens_hsa05166	0.06811237
100	Sulfur metabolism_Homo sapiens_hsa00920	0.06417237

GAGE2A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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