ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	diterpenoid biosynthetic process (GO:0016102)	5.86131088
2	regulation of translational fidelity (GO:0006450)	5.80317061
3	formation of translation preinitiation complex (GO:0001731)	5.34950812
4	DNA unwinding involved in DNA replication (GO:0006268)	5.30176957
5	nuclear pore complex assembly (GO:0051292)	5.25327279
6	terpenoid biosynthetic process (GO:0016114)	4.90991398
7	DNA replication checkpoint (GO:0000076)	4.79850151
8	nuclear pore organization (GO:0006999)	4.67722670
9	ribosomal small subunit biogenesis (GO:0042274)	4.63883874
10	ribosomal small subunit assembly (GO:0000028)	4.52765737
11	proline biosynthetic process (GO:0006561)	4.47926864
12	homocysteine metabolic process (GO:0050667)	4.42524167
13	oxidative phosphorylation (GO:0006119)	4.36293940
14	ribosome assembly (GO:0042255)	4.32095038
15	mitotic sister chromatid segregation (GO:0000070)	4.27062275
16	viral transcription (GO:0019083)	4.23394811
17	translational termination (GO:0006415)	4.15269828
18	ribosomal large subunit biogenesis (GO:0042273)	4.13726945
19	DNA replication initiation (GO:0006270)	4.05896343
20	ribonucleoprotein complex biogenesis (GO:0022613)	4.04188977
21	regulation of histone H3-K27 methylation (GO:0061085)	4.01103748
22	sister chromatid segregation (GO:0000819)	3.92243233
23	ribosome biogenesis (GO:0042254)	3.90725311
24	mitotic nuclear envelope disassembly (GO:0007077)	3.87357666
25	DNA topological change (GO:0006265)	3.86881886
26	regulation of RNA export from nucleus (GO:0046831)	3.84311230
27	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.83193675
28	oxaloacetate metabolic process (GO:0006107)	3.80837466
29	translational initiation (GO:0006413)	3.79729084
30	pore complex assembly (GO:0046931)	3.79416011
31	DNA strand elongation involved in DNA replication (GO:0006271)	3.76792560
32	maturation of SSU-rRNA (GO:0030490)	3.74326678
33	DNA strand elongation (GO:0022616)	3.72637490
34	tRNA aminoacylation for protein translation (GO:0006418)	3.72391859
35	protoporphyrinogen IX metabolic process (GO:0046501)	3.69430160
36	regulation of histone H3-K4 methylation (GO:0051569)	3.68815649
37	regulation of mitotic spindle organization (GO:0060236)	3.68235292
38	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.67830169
39	ATP synthesis coupled proton transport (GO:0015986)	3.66632663
40	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.66632663
41	oxygen transport (GO:0015671)	3.64949578
42	translational elongation (GO:0006414)	3.62069184
43	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.61826057
44	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.61662654
45	gas transport (GO:0015669)	3.58640063
46	tRNA aminoacylation (GO:0043039)	3.55995946
47	amino acid activation (GO:0043038)	3.55995946
48	purine nucleobase biosynthetic process (GO:0009113)	3.55154576
49	nuclear envelope disassembly (GO:0051081)	3.53838240
50	membrane disassembly (GO:0030397)	3.53838240
51	cotranslational protein targeting to membrane (GO:0006613)	3.50575891
52	regulation of translational elongation (GO:0006448)	3.47486487
53	protein targeting to ER (GO:0045047)	3.47076500
54	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.46898402
55	meiotic chromosome segregation (GO:0045132)	3.44195773
56	erythrocyte maturation (GO:0043249)	3.38791538
57	cellular protein complex disassembly (GO:0043624)	3.38785931
58	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.37564637
59	mitotic chromosome condensation (GO:0007076)	3.37058214
60	nucleobase biosynthetic process (GO:0046112)	3.35453867
61	Golgi transport vesicle coating (GO:0048200)	3.32322550
62	COPI coating of Golgi vesicle (GO:0048205)	3.32322550
63	creatine metabolic process (GO:0006600)	3.31874785
64	protein localization to endoplasmic reticulum (GO:0070972)	3.31338576
65	resolution of meiotic recombination intermediates (GO:0000712)	3.30879110
66	proteasome assembly (GO:0043248)	3.28026897
67	IMP biosynthetic process (GO:0006188)	3.27617573
68	protein complex disassembly (GO:0043241)	3.26608046
69	viral life cycle (GO:0019058)	3.23949698
70	translation (GO:0006412)	3.19804489
71	folic acid-containing compound biosynthetic process (GO:0009396)	3.18640891
72	macromolecular complex disassembly (GO:0032984)	3.18388876
73	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.15106977
74	protein-cofactor linkage (GO:0018065)	3.11150746
75	respiratory electron transport chain (GO:0022904)	3.05533301
76	regulation of nucleobase-containing compound transport (GO:0032239)	3.04447881
77	response to vitamin A (GO:0033189)	3.03944465
78	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	3.00666852
79	purine nucleoside monophosphate biosynthetic process (GO:0009127)	3.00666852
80	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.98918622
81	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.98292030
82	chromosome segregation (GO:0007059)	2.97886936
83	electron transport chain (GO:0022900)	2.96602832
84	telomere maintenance via semi-conservative replication (GO:0032201)	2.93330446
85	regulation of gene expression by genetic imprinting (GO:0006349)	2.91685243
86	aerobic respiration (GO:0009060)	2.91347962
87	ATP biosynthetic process (GO:0006754)	2.90937011
88	succinate metabolic process (GO:0006105)	2.90717063
89	IMP metabolic process (GO:0046040)	2.88140825
90	cellular component biogenesis (GO:0044085)	2.87197095
91	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.85792791
92	tetrahydrofolate metabolic process (GO:0046653)	2.85065386
93	regulation of retinoic acid receptor signaling pathway (GO:0048385)	2.84754801
94	pseudouridine synthesis (GO:0001522)	2.83833114
95	transcription from mitochondrial promoter (GO:0006390)	2.82603531
96	tricarboxylic acid cycle (GO:0006099)	2.82415543
97	rRNA processing (GO:0006364)	2.82337340
98	maturation of 5.8S rRNA (GO:0000460)	2.81780355
99	ribonucleoside monophosphate biosynthetic process (GO:0009156)	2.81724837
100	nucleobase-containing small molecule interconversion (GO:0015949)	2.81082952

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.47659175
2	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.93099450
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.73137955
4	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.60283991
5	ZNF263_19887448_ChIP-Seq_K562_Human	3.16779267
6	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.09146128
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.97443405
8	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.81983768
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.78240720
10	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.77762050
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.66777768
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.59249287
13	XRN2_22483619_ChIP-Seq_HELA_Human	2.53735677
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.53290040
15	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.48984147
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.47483557
17	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.46554301
18	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.45220573
19	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.24279224
20	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.19827048
21	NCOR1_26117541_ChIP-Seq_K562_Human	2.18477044
22	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.15414855
23	DCP1A_22483619_ChIP-Seq_HELA_Human	2.09140882
24	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.06398336
25	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.01270069
26	TTF2_22483619_ChIP-Seq_HELA_Human	2.00253861
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.90334773
28	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.88966975
29	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.84753671
30	GABP_19822575_ChIP-Seq_HepG2_Human	1.79188852
31	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.76425168
32	KDM5A_27292631_Chip-Seq_BREAST_Human	1.72761951
33	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.72145392
34	AR_21909140_ChIP-Seq_LNCAP_Human	1.68403810
35	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.68160104
36	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.63370333
37	GATA1_19941826_ChIP-Seq_K562_Human	1.58991130
38	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.57064878
39	MYC_22102868_ChIP-Seq_BL_Human	1.56608055
40	FOXP3_21729870_ChIP-Seq_TREG_Human	1.55586418
41	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.54789586
42	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.53766079
43	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.53489457
44	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.47334203
45	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.45363900
46	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.44378149
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.43671569
48	VDR_23849224_ChIP-Seq_CD4+_Human	1.43617166
49	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.43569625
50	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.43066574
51	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.40504913
52	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.37207066
53	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.34673051
54	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.34626006
55	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.33416527
56	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.32188574
57	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.31943290
58	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.31560110
59	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.29987101
60	ELK1_19687146_ChIP-ChIP_HELA_Human	1.29136213
61	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.26624654
62	CIITA_25753668_ChIP-Seq_RAJI_Human	1.26206783
63	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.24521556
64	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.21376863
65	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.19518593
66	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.19019556
67	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.16863615
68	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.16290537
69	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.15178758
70	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.10660654
71	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.10541841
72	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.09024985
73	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.08937020
74	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.06085148
75	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.02814787
76	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.02145031
77	TFEB_21752829_ChIP-Seq_HELA_Human	1.02092130
78	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.00987623
79	VDR_21846776_ChIP-Seq_THP-1_Human	1.00908321
80	GATA1_22025678_ChIP-Seq_K562_Human	1.00880148
81	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.00648708
82	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.99994405
83	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.99695159
84	GATA2_19941826_ChIP-Seq_K562_Human	0.99612696
85	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.99191825
86	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.98806781
87	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.97868515
88	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.96125103
89	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.94493131
90	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.93366795
91	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.91455592
92	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.91247081
93	CHD1_26751641_Chip-Seq_LNCaP_Human	0.90939316
94	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.90669417
95	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.90134274
96	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.89840820
97	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.89472773
98	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.88037574
99	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.86421197
100	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.85499061

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004957_abnormal_blastocyst_morpholog	4.19583641
2	MP0003111_abnormal_nucleus_morphology	3.78776799
3	MP0003693_abnormal_embryo_hatching	3.59052417
4	MP0004147_increased_porphyrin_level	3.42860470
5	MP0010094_abnormal_chromosome_stability	3.33920462
6	MP0000678_abnormal_parathyroid_gland	3.20456110
7	MP0008058_abnormal_DNA_repair	3.17080385
8	MP0008995_early_reproductive_senescence	3.16590185
9	MP0003656_abnormal_erythrocyte_physiolo	2.86749109
10	MP0008932_abnormal_embryonic_tissue	2.73372129
11	MP0005451_abnormal_body_composition	2.67823070
12	MP0004145_abnormal_muscle_electrophysio	2.56962227
13	MP0003077_abnormal_cell_cycle	2.56756832
14	MP0003806_abnormal_nucleotide_metabolis	2.55774346
15	MP0009697_abnormal_copulation	2.41704546
16	MP0008007_abnormal_cellular_replicative	2.30102164
17	MP0003786_premature_aging	2.28764588
18	MP0008057_abnormal_DNA_replication	2.26611476
19	MP0003718_maternal_effect	2.15142562
20	MP0004233_abnormal_muscle_weight	2.11803106
21	MP0001730_embryonic_growth_arrest	2.00434732
22	MP0003186_abnormal_redox_activity	2.00430283
23	MP0005083_abnormal_biliary_tract	1.93967050
24	MP0005171_absent_coat_pigmentation	1.92580315
25	MP0000350_abnormal_cell_proliferation	1.87689896
26	MP0006036_abnormal_mitochondrial_physio	1.82961719
27	MP0000372_irregular_coat_pigmentation	1.81869386
28	MP0001661_extended_life_span	1.76704537
29	MP0001697_abnormal_embryo_size	1.69079905
30	MP0001672_abnormal_embryogenesis/_devel	1.66460960
31	MP0005380_embryogenesis_phenotype	1.66460960
32	MP0005408_hypopigmentation	1.60964675
33	MP0003984_embryonic_growth_retardation	1.60640203
34	MP0002396_abnormal_hematopoietic_system	1.60209264
35	MP0002080_prenatal_lethality	1.59490027
36	MP0002088_abnormal_embryonic_growth/wei	1.53658345
37	MP0006035_abnormal_mitochondrial_morpho	1.49518415
38	MP0000313_abnormal_cell_death	1.44345581
39	MP0005397_hematopoietic_system_phenotyp	1.44335382
40	MP0001545_abnormal_hematopoietic_system	1.44335382
41	MP0005636_abnormal_mineral_homeostasis	1.38905231
42	MP0002086_abnormal_extraembryonic_tissu	1.38264223
43	MP0002210_abnormal_sex_determination	1.32031947
44	MP0009379_abnormal_foot_pigmentation	1.30663557
45	MP0003705_abnormal_hypodermis_morpholog	1.30099019
46	MP0003959_abnormal_lean_body	1.25993691
47	MP0010307_abnormal_tumor_latency	1.21556010
48	MP0004185_abnormal_adipocyte_glucose	1.19173714
49	MP0001929_abnormal_gametogenesis	1.15167422
50	MP0002877_abnormal_melanocyte_morpholog	1.12242998
51	MP0000358_abnormal_cell_content/	1.10922089
52	MP0002095_abnormal_skin_pigmentation	1.07047698
53	MP0009333_abnormal_splenocyte_physiolog	1.06050703
54	MP0002132_abnormal_respiratory_system	1.05133454
55	MP0002085_abnormal_embryonic_tissue	1.03631522
56	MP0002269_muscular_atrophy	1.02851265
57	MP0005058_abnormal_lysosome_morphology	1.02779236
58	MP0003385_abnormal_body_wall	1.00422794
59	MP0002249_abnormal_larynx_morphology	0.99215223
60	MP0001881_abnormal_mammary_gland	0.96371395
61	MP0002084_abnormal_developmental_patter	0.95734652
62	MP0000681_abnormal_thyroid_gland	0.94039162
63	MP0001873_stomach_inflammation	0.93743760
64	MP0003699_abnormal_female_reproductive	0.93651036
65	MP0002019_abnormal_tumor_incidence	0.92469586
66	MP0005501_abnormal_skin_physiology	0.89796992
67	MP0003950_abnormal_plasma_membrane	0.88229038
68	MP0000647_abnormal_sebaceous_gland	0.86781679
69	MP0009278_abnormal_bone_marrow	0.85756933
70	MP0005410_abnormal_fertilization	0.85074801
71	MP0008770_decreased_survivor_rate	0.84552441
72	MP0003698_abnormal_male_reproductive	0.83230490
73	MP0001145_abnormal_male_reproductive	0.82975642
74	MP0010234_abnormal_vibrissa_follicle	0.81175730
75	MP0008775_abnormal_heart_ventricle	0.81046463
76	MP0001502_abnormal_circadian_rhythm	0.79021894
77	MP0002009_preneoplasia	0.78129785
78	MP0009672_abnormal_birth_weight	0.76988827
79	MP0002161_abnormal_fertility/fecundity	0.76851448
80	MP0000653_abnormal_sex_gland	0.74069878
81	MP0000609_abnormal_liver_physiology	0.73428549
82	MP0004197_abnormal_fetal_growth/weight/	0.72472955
83	MP0010630_abnormal_cardiac_muscle	0.72377142
84	MP0000703_abnormal_thymus_morphology	0.72374533
85	MP0001764_abnormal_homeostasis	0.71938296
86	MP0002796_impaired_skin_barrier	0.71736675
87	MP0004808_abnormal_hematopoietic_stem	0.71139403
88	MP0001727_abnormal_embryo_implantation	0.70817577
89	MP0003221_abnormal_cardiomyocyte_apopto	0.70727424
90	MP0004782_abnormal_surfactant_physiolog	0.69088081
91	MP0009931_abnormal_skin_appearance	0.68665401
92	MP0000750_abnormal_muscle_regeneration	0.66975988
93	MP0005332_abnormal_amino_acid	0.66956441
94	MP0004019_abnormal_vitamin_homeostasis	0.66879890
95	MP0003567_abnormal_fetal_cardiomyocyte	0.66856540
96	MP0005330_cardiomyopathy	0.65904240
97	MP0006138_congestive_heart_failure	0.64279177
98	MP0008260_abnormal_autophagy	0.63964421
99	MP0000747_muscle_weakness	0.62563440
100	MP0003123_paternal_imprinting	0.62465880

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cholecystitis (HP:0001082)	6.64934355
2	Abnormal gallbladder physiology (HP:0012438)	6.64934355
3	Truncus arteriosus (HP:0001660)	6.47165816
4	Hyperthyroidism (HP:0000836)	6.06454837
5	Reticulocytosis (HP:0001923)	5.39284766
6	Abnormality of reticulocytes (HP:0004312)	4.61192334
7	Hypertensive crisis (HP:0100735)	4.38860827
8	Seborrheic dermatitis (HP:0001051)	4.38706415
9	Ileus (HP:0002595)	4.24165117
10	Polycythemia (HP:0001901)	4.07609831
11	Ankyloglossia (HP:0010296)	3.86841290
12	Bowel incontinence (HP:0002607)	3.86705276
13	Abnormality of the tricuspid valve (HP:0001702)	3.76830516
14	Abnormal large intestine physiology (HP:0012700)	3.69720837
15	Cholelithiasis (HP:0001081)	3.65099810
16	Hypoparathyroidism (HP:0000829)	3.60342043
17	Abnormality of cells of the erythroid lineage (HP:0012130)	3.59338544
18	Birth length less than 3rd percentile (HP:0003561)	3.55932034
19	Abnormality of glycolysis (HP:0004366)	3.55031971
20	Upper limb muscle weakness (HP:0003484)	3.32380164
21	Abnormal number of erythroid precursors (HP:0012131)	3.31068062
22	Increased serum pyruvate (HP:0003542)	3.30445691
23	Pallor (HP:0000980)	3.25241009
24	Abnormal hemoglobin (HP:0011902)	3.25040237
25	Atelectasis (HP:0100750)	3.21224960
26	Abnormal gallbladder morphology (HP:0012437)	3.20488840
27	Homocystinuria (HP:0002156)	3.11892015
28	Abnormality of homocysteine metabolism (HP:0010919)	3.11892015
29	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.11578383
30	Reticulocytopenia (HP:0001896)	2.96330533
31	Cortical dysplasia (HP:0002539)	2.95483679
32	Abnormally folded helix (HP:0008544)	2.73217114
33	Abnormality of the gallbladder (HP:0005264)	2.69874230
34	Spastic paraparesis (HP:0002313)	2.67336356
35	Nonimmune hydrops fetalis (HP:0001790)	2.65485354
36	Tinnitus (HP:0000360)	2.63841699
37	Abnormality of oral frenula (HP:0000190)	2.63085019
38	Acute encephalopathy (HP:0006846)	2.56221653
39	Aplasia/Hypoplasia of the thymus (HP:0010515)	2.49722141
40	Abnormality of cochlea (HP:0000375)	2.48811200
41	Hyperbilirubinemia (HP:0002904)	2.45916695
42	Macrocytic anemia (HP:0001972)	2.44016163
43	Disproportionate tall stature (HP:0001519)	2.43226172
44	Patellar dislocation (HP:0002999)	2.40477342
45	Chromsome breakage (HP:0040012)	2.39878799
46	Poikilocytosis (HP:0004447)	2.37916181
47	Breast hypoplasia (HP:0003187)	2.36548924
48	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.35779554
49	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.34775331
50	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.32799357
51	Peripheral hypomyelination (HP:0007182)	2.32690566
52	Dysmetric saccades (HP:0000641)	2.32443214
53	Flat cornea (HP:0007720)	2.31275541
54	Abnormal mitochondria in muscle tissue (HP:0008316)	2.30168694
55	Myopathic facies (HP:0002058)	2.28278009
56	Cheekbone underdevelopment (HP:0010669)	2.24458367
57	Esophageal neoplasm (HP:0100751)	2.23116885
58	Neoplasm of head and neck (HP:0012288)	2.23116885
59	Duplicated collecting system (HP:0000081)	2.22992477
60	Acute necrotizing encephalopathy (HP:0006965)	2.19925042
61	Redundant skin (HP:0001582)	2.16022397
62	Palpitations (HP:0001962)	2.15143219
63	Acute myeloid leukemia (HP:0004808)	2.14999017
64	Septate vagina (HP:0001153)	2.14682793
65	Ureteral duplication (HP:0000073)	2.12029490
66	Morphological abnormality of the inner ear (HP:0011390)	2.11586504
67	Cerebral hypomyelination (HP:0006808)	2.06852229
68	Pheochromocytoma (HP:0002666)	2.05023814
69	Progressive muscle weakness (HP:0003323)	2.04563063
70	Overfolded helix (HP:0000396)	2.03590107
71	Insomnia (HP:0100785)	2.00697257
72	Orthostatic hypotension (HP:0001278)	1.99920204
73	Breech presentation (HP:0001623)	1.98108491
74	Multiple enchondromatosis (HP:0005701)	1.95814787
75	Fatigue (HP:0012378)	1.93818449
76	Increased serum lactate (HP:0002151)	1.92332675
77	Overlapping toe (HP:0001845)	1.90662080
78	Venous insufficiency (HP:0005293)	1.90058447
79	Angiofibromas (HP:0010615)	1.86048802
80	Adenoma sebaceum (HP:0009720)	1.86048802
81	Abnormality of the renal collecting system (HP:0004742)	1.85273665
82	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.84981106
83	Abnormality of alanine metabolism (HP:0010916)	1.84981106
84	Hyperalaninemia (HP:0003348)	1.84981106
85	Short middle phalanx of the 5th finger (HP:0004220)	1.84963308
86	Neuroendocrine neoplasm (HP:0100634)	1.83640576
87	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.83632745
88	Venous abnormality (HP:0002624)	1.82183474
89	Concave nail (HP:0001598)	1.80452900
90	Overriding aorta (HP:0002623)	1.79209715
91	Male infertility (HP:0003251)	1.73794199
92	Premature ovarian failure (HP:0008209)	1.72597142
93	Cerebral edema (HP:0002181)	1.71092070
94	Increased CSF lactate (HP:0002490)	1.70880004
95	Attention deficit hyperactivity disorder (HP:0007018)	1.70446428
96	Obstructive lung disease (HP:0006536)	1.68682299
97	Chronic obstructive pulmonary disease (HP:0006510)	1.68682299
98	Sparse lateral eyebrow (HP:0005338)	1.67011907
99	Acanthocytosis (HP:0001927)	1.66632597
100	Myelodysplasia (HP:0002863)	1.66073794

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	4.82729705
2	EEF2K	3.42112747
3	PDK2	3.13487695
4	RIPK4	3.06620464
5	PBK	3.02645946
6	TTK	2.89498308
7	KSR2	2.66059069
8	NEK1	2.65399931
9	WNK4	2.62946635
10	IRAK3	2.55349371
11	BUB1	2.44724644
12	CLK1	2.36368631
13	CDK12	2.26556480
14	BMPR2	2.20940012
15	CDC7	2.12533290
16	ICK	2.08318498
17	NME2	2.01688649
18	TSSK6	1.84911638
19	SRPK1	1.79511807
20	BMX	1.78719374
21	RAF1	1.77088996
22	MAP3K2	1.70706596
23	EIF2AK3	1.67280288
24	NME1	1.65043686
25	WEE1	1.63756534
26	MAP3K8	1.63271937
27	TRIB3	1.61991424
28	MST1R	1.49045905
29	NTRK3	1.42170481
30	RPS6KB2	1.40679429
31	PLK4	1.37289071
32	AKT3	1.33803367
33	BRSK1	1.30585618
34	NEK2	1.27034184
35	BRAF	1.26573144
36	CHEK2	1.24404230
37	BRSK2	1.18617324
38	SCYL2	1.11879586
39	MST4	1.08899629
40	ILK	1.05962279
41	LATS2	1.05769683
42	ERN1	1.03045407
43	KSR1	1.01548132
44	CHEK1	0.97863103
45	MAPKAPK3	0.96804875
46	STK4	0.96804487
47	CCNB1	0.96314808
48	ALK	0.92809457
49	LRRK2	0.92061911
50	PAK1	0.87917265
51	ATR	0.85363857
52	JAK3	0.84044359
53	CDK8	0.83007398
54	MET	0.82956624
55	CDK7	0.78841526
56	MTOR	0.78625747
57	WNK1	0.76569960
58	STK10	0.76087001
59	CDK1	0.72338152
60	MAPKAPK5	0.70221611
61	CDK2	0.68659540
62	PLK3	0.67789034
63	PLK1	0.65638425
64	STK3	0.61962078
65	AURKB	0.60668020
66	NTRK1	0.60146898
67	PKN2	0.59639730
68	AURKA	0.57258436
69	CSNK2A2	0.56105388
70	PRKG2	0.55294795
71	ATM	0.55110584
72	CSNK1E	0.54978851
73	PTK6	0.53740721
74	MAP2K1	0.52205151
75	DMPK	0.52056677
76	MKNK1	0.48624029
77	PAK2	0.46280217
78	SMG1	0.45810376
79	PAK4	0.42951349
80	MAP3K1	0.42726830
81	MARK3	0.42017010
82	TRPM7	0.40377900
83	CSNK2A1	0.39202847
84	AKT2	0.38974307
85	CDK4	0.38769212
86	EIF2AK2	0.34499134
87	JAK2	0.31075576
88	GSK3B	0.30100127
89	TAOK2	0.28774470
90	PRKCI	0.28713952
91	PIM1	0.27957030
92	MAPK10	0.26933374
93	MAP3K7	0.26618962
94	AKT1	0.26590152
95	CDK11A	0.26356390
96	MAPK14	0.25079630
97	MAP3K10	0.24950704
98	RPS6KA5	0.24726307
99	PRPF4B	0.24225342
100	RPS6KA4	0.23939980

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.13297335
2	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	4.03436839
3	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	3.67912289
4	DNA replication_Homo sapiens_hsa03030	3.23676422
5	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.09952389
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.99332014
7	Homologous recombination_Homo sapiens_hsa03440	2.79276760
8	One carbon pool by folate_Homo sapiens_hsa00670	2.71858643
9	Mismatch repair_Homo sapiens_hsa03430	2.67558239
10	RNA transport_Homo sapiens_hsa03013	2.58184468
11	Spliceosome_Homo sapiens_hsa03040	2.39154994
12	Parkinsons disease_Homo sapiens_hsa05012	2.09857440
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.01576438
14	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.90521566
15	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.87771539
16	Pyruvate metabolism_Homo sapiens_hsa00620	1.79922726
17	RNA polymerase_Homo sapiens_hsa03020	1.77949855
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.75354644
19	mRNA surveillance pathway_Homo sapiens_hsa03015	1.73335681
20	Carbon metabolism_Homo sapiens_hsa01200	1.72815146
21	Proteasome_Homo sapiens_hsa03050	1.72541274
22	Cell cycle_Homo sapiens_hsa04110	1.71516057
23	Basal transcription factors_Homo sapiens_hsa03022	1.66520020
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.63787392
25	Huntingtons disease_Homo sapiens_hsa05016	1.59460292
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.53616367
27	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.46412926
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45960268
29	Base excision repair_Homo sapiens_hsa03410	1.43687645
30	Sulfur relay system_Homo sapiens_hsa04122	1.41527609
31	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.38362239
32	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.35228535
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.26671497
34	Alzheimers disease_Homo sapiens_hsa05010	1.23684681
35	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.23211641
36	Steroid biosynthesis_Homo sapiens_hsa00100	1.12738428
37	Arginine biosynthesis_Homo sapiens_hsa00220	1.11318058
38	Acute myeloid leukemia_Homo sapiens_hsa05221	1.04384101
39	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.03359041
40	Pentose phosphate pathway_Homo sapiens_hsa00030	1.01322544
41	Selenocompound metabolism_Homo sapiens_hsa00450	1.00302233
42	Folate biosynthesis_Homo sapiens_hsa00790	1.00201728
43	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.98959718
44	RNA degradation_Homo sapiens_hsa03018	0.98441613
45	Purine metabolism_Homo sapiens_hsa00230	0.92116176
46	Thyroid cancer_Homo sapiens_hsa05216	0.90874187
47	Tyrosine metabolism_Homo sapiens_hsa00350	0.90861637
48	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.89024225
49	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.82955535
50	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.78458277
51	Cardiac muscle contraction_Homo sapiens_hsa04260	0.75715114
52	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.72925707
53	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.72196415
54	Non-homologous end-joining_Homo sapiens_hsa03450	0.71912049
55	mTOR signaling pathway_Homo sapiens_hsa04150	0.70719770
56	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.69403818
57	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.68254176
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.66247350
59	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.65996269
60	Insulin signaling pathway_Homo sapiens_hsa04910	0.63910867
61	Galactose metabolism_Homo sapiens_hsa00052	0.63235347
62	Protein export_Homo sapiens_hsa03060	0.62603035
63	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.62047637
64	Oocyte meiosis_Homo sapiens_hsa04114	0.59050265
65	ErbB signaling pathway_Homo sapiens_hsa04012	0.58040757
66	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.57742254
67	Prion diseases_Homo sapiens_hsa05020	0.56392950
68	Metabolic pathways_Homo sapiens_hsa01100	0.55901604
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.55260793
70	VEGF signaling pathway_Homo sapiens_hsa04370	0.52518678
71	Arginine and proline metabolism_Homo sapiens_hsa00330	0.52339762
72	Pancreatic cancer_Homo sapiens_hsa05212	0.51273776
73	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47864228
74	Glutathione metabolism_Homo sapiens_hsa00480	0.47650424
75	Sulfur metabolism_Homo sapiens_hsa00920	0.45741331
76	Renal cell carcinoma_Homo sapiens_hsa05211	0.45173669
77	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.44214665
78	Viral carcinogenesis_Homo sapiens_hsa05203	0.43982211
79	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.43806807
80	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.43274397
81	Bladder cancer_Homo sapiens_hsa05219	0.41234136
82	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.34803181
83	Olfactory transduction_Homo sapiens_hsa04740	0.34268536
84	Propanoate metabolism_Homo sapiens_hsa00640	0.31234269
85	Non-small cell lung cancer_Homo sapiens_hsa05223	0.30154512
86	Type II diabetes mellitus_Homo sapiens_hsa04930	0.30140624
87	Fatty acid elongation_Homo sapiens_hsa00062	0.26809071
88	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.23836237
89	Phenylalanine metabolism_Homo sapiens_hsa00360	0.22383247
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.21682084
91	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.19322707
92	Lysine degradation_Homo sapiens_hsa00310	0.18605197
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.18091891
94	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.16170045
95	MicroRNAs in cancer_Homo sapiens_hsa05206	0.15302203
96	AMPK signaling pathway_Homo sapiens_hsa04152	0.14586791
97	p53 signaling pathway_Homo sapiens_hsa04115	0.14314725
98	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.13464224
99	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.12480993
100	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.11887320

GAGE2E

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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