GAK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.40037530
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.40037530
3positive regulation of gamma-delta T cell activation (GO:0046645)4.25244060
4COPI coating of Golgi vesicle (GO:0048205)4.04476756
5Golgi transport vesicle coating (GO:0048200)4.04476756
6antigen processing and presentation of endogenous antigen (GO:0019883)3.91053538
7regulation of gamma-delta T cell differentiation (GO:0045586)3.83688821
8regulation of cholesterol homeostasis (GO:2000188)3.57952017
9regulation of gamma-delta T cell activation (GO:0046643)3.56368298
10response to muramyl dipeptide (GO:0032495)3.54832353
11response to peptidoglycan (GO:0032494)3.49921988
12NIK/NF-kappaB signaling (GO:0038061)3.48793847
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.47442098
14positive regulation of histone deacetylation (GO:0031065)3.45515534
15detection of bacterium (GO:0016045)3.43661015
16detection of other organism (GO:0098543)3.42145419
17negative regulation of cell killing (GO:0031342)3.33197851
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.33197851
19germinal center formation (GO:0002467)3.29593546
20antigen processing and presentation via MHC class Ib (GO:0002475)3.14278202
21positive regulation of Cdc42 GTPase activity (GO:0043089)3.10548302
22positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.09422634
23leukocyte aggregation (GO:0070486)3.02340023
24low-density lipoprotein particle clearance (GO:0034383)3.01736617
25immunoglobulin mediated immune response (GO:0016064)3.00395703
26positive thymic T cell selection (GO:0045059)2.99720707
27negative regulation of interleukin-12 production (GO:0032695)2.97259753
28L-alpha-amino acid transmembrane transport (GO:1902475)2.92016139
29activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.89868552
30regulation of cholesterol storage (GO:0010885)2.89668692
31hepatocyte apoptotic process (GO:0097284)2.89557672
32detection of external biotic stimulus (GO:0098581)2.88545805
33regulation of interleukin-12 biosynthetic process (GO:0045075)2.88389742
34apoptotic cell clearance (GO:0043277)2.88004150
35mannose metabolic process (GO:0006013)2.87933422
36regulation of leukocyte degranulation (GO:0043300)2.85785083
37JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.85005997
38lipopolysaccharide-mediated signaling pathway (GO:0031663)2.83353921
39regulation of interferon-beta biosynthetic process (GO:0045357)2.82805389
40response to type I interferon (GO:0034340)2.82058921
41positive regulation of nuclease activity (GO:0032075)2.81196122
42neutrophil activation involved in immune response (GO:0002283)2.80304915
43type I interferon signaling pathway (GO:0060337)2.78554866
44cellular response to type I interferon (GO:0071357)2.78554866
45regulation of dendritic cell antigen processing and presentation (GO:0002604)2.76781239
46regulation of type I interferon-mediated signaling pathway (GO:0060338)2.73660941
47growth hormone receptor signaling pathway (GO:0060396)2.72270956
48epithelial cell differentiation involved in prostate gland development (GO:0060742)2.71615800
49regulation of myeloid leukocyte mediated immunity (GO:0002886)2.69954329
50pentose-phosphate shunt (GO:0006098)2.69772388
51negative regulation of cell size (GO:0045792)2.69462412
52protein localization to endosome (GO:0036010)2.69272965
53negative thymic T cell selection (GO:0045060)2.67248579
54alpha-linolenic acid metabolic process (GO:0036109)2.66443072
55regulation of mast cell degranulation (GO:0043304)2.64918191
56negative regulation of erythrocyte differentiation (GO:0045647)2.64878657
57Arp2/3 complex-mediated actin nucleation (GO:0034314)2.64434488
58regulation of T-helper 2 cell differentiation (GO:0045628)2.64278253
59cellular extravasation (GO:0045123)2.61982045
60negative T cell selection (GO:0043383)2.60313634
61positive regulation by symbiont of host defense response (GO:0052509)2.58796856
62modulation by symbiont of host defense response (GO:0052031)2.58796856
63modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.58796856
64modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.58796856
65positive regulation by organism of defense response of other organism involved in symbiotic interact2.58796856
66modulation by symbiont of host immune response (GO:0052553)2.58796856
67regulation of nuclease activity (GO:0032069)2.57922641
68interferon-gamma-mediated signaling pathway (GO:0060333)2.56535551
69retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.54873665
70receptor catabolic process (GO:0032801)2.53088331
71natural killer cell differentiation (GO:0001779)2.53051763
72negative regulation of leukocyte mediated immunity (GO:0002704)2.53002064
73regulation of necroptotic process (GO:0060544)2.52430637
74thymic T cell selection (GO:0045061)2.52192904
75regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.51666999
76detection of biotic stimulus (GO:0009595)2.51400361
77negative regulation of granulocyte differentiation (GO:0030853)2.50673830
78detection of molecule of bacterial origin (GO:0032490)2.49580442
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.49572868
80positive regulation of lamellipodium assembly (GO:0010592)2.49566784
81histone H3-K36 demethylation (GO:0070544)2.48229048
82vesicle coating (GO:0006901)2.48207261
83COPII vesicle coating (GO:0048208)2.48173772
84endoplasmic reticulum unfolded protein response (GO:0030968)2.47400969
85phospholipid homeostasis (GO:0055091)2.46866447
86regulation of fatty acid beta-oxidation (GO:0031998)2.45815857
87negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.45501298
88negative regulation of toll-like receptor signaling pathway (GO:0034122)2.44300362
89positive regulation of protein deacetylation (GO:0090312)2.44098338
90barbed-end actin filament capping (GO:0051016)2.43604546
91negative regulation of lymphocyte mediated immunity (GO:0002707)2.43501574
92myeloid dendritic cell differentiation (GO:0043011)2.42951078
93modulation by symbiont of host cellular process (GO:0044068)2.42840619
94positive regulation of p38MAPK cascade (GO:1900745)2.42145721
95response to host immune response (GO:0052572)2.40916129
96response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.40916129
97response to host (GO:0075136)2.40819441
98response to host defenses (GO:0052200)2.40819441
99response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.40819441
100regulation of extracellular matrix disassembly (GO:0010715)2.38923928
101regulation of B cell receptor signaling pathway (GO:0050855)2.38836730
102signal complex assembly (GO:0007172)2.38621866
103tolerance induction (GO:0002507)2.38490188
104macrophage activation involved in immune response (GO:0002281)2.38460516
105NADPH regeneration (GO:0006740)2.37227598
106regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.37135294
107negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.36635328
108intestinal cholesterol absorption (GO:0030299)2.36135121
109embryonic process involved in female pregnancy (GO:0060136)2.35521736
110regulation of T cell tolerance induction (GO:0002664)2.35211222
111negative regulation of innate immune response (GO:0045824)2.34908853
112positive regulation of Rap GTPase activity (GO:0032854)2.34763786
113regulation of regulated secretory pathway (GO:1903305)2.34707148
114positive regulation of cellular amide metabolic process (GO:0034250)2.34581771
115cytoskeletal anchoring at plasma membrane (GO:0007016)2.33987650
116regulation of translational fidelity (GO:0006450)2.33495330
117negative regulation of myotube differentiation (GO:0010832)2.33177276
118cellular response to unfolded protein (GO:0034620)2.32860056
119cellular response to growth hormone stimulus (GO:0071378)2.32395360
120positive regulation of B cell differentiation (GO:0045579)2.32246259
121regulation of defense response to virus by virus (GO:0050690)2.31924744
122T cell migration (GO:0072678)2.31624655
123regulation of mast cell activation involved in immune response (GO:0033006)2.31402616
124negative regulation of lipid transport (GO:0032369)2.30361614
125defense response to protozoan (GO:0042832)2.29666012
126ER-nucleus signaling pathway (GO:0006984)2.28800174
127sodium ion export (GO:0071436)2.28423803
128myeloid cell activation involved in immune response (GO:0002275)2.28256285
129negative regulation of cytokine production involved in immune response (GO:0002719)2.28242478
130regulation of antigen processing and presentation (GO:0002577)2.28066379
131maternal placenta development (GO:0001893)2.25655038
132regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.25623798
133regulation of tolerance induction (GO:0002643)2.25534285
134response to protozoan (GO:0001562)2.25368979
135positive regulation of lamellipodium organization (GO:1902745)2.25208037
136positive regulation of antigen processing and presentation (GO:0002579)2.24736278
137macroautophagy (GO:0016236)2.24596478
138response to laminar fluid shear stress (GO:0034616)2.24553110
139protein-lipid complex assembly (GO:0065005)2.24305088
140cell adhesion mediated by integrin (GO:0033627)2.23633323
141positive regulation of interferon-alpha production (GO:0032727)2.21339151
142urea cycle (GO:0000050)2.20679977
143urea metabolic process (GO:0019627)2.20679977
144positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.20565421
145regulation of ARF protein signal transduction (GO:0032012)2.19439825
146fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.19269602
147negative regulation of sterol transport (GO:0032372)2.19035589
148negative regulation of cholesterol transport (GO:0032375)2.19035589
149regulation of translational termination (GO:0006449)2.18885659
150maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.17506871
151dicarboxylic acid biosynthetic process (GO:0043650)2.17504878
152glucocorticoid receptor signaling pathway (GO:0042921)2.16166732
153positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.16032239
154leukocyte cell-cell adhesion (GO:0007159)2.15380090
155valine metabolic process (GO:0006573)2.14597924
156intestinal absorption (GO:0050892)2.12921351
157T cell selection (GO:0045058)2.11902817
158regulation of ARF GTPase activity (GO:0032312)2.11770571
159B cell receptor signaling pathway (GO:0050853)2.11646853
160regulation of response to interferon-gamma (GO:0060330)2.10606611
161cellular response to topologically incorrect protein (GO:0035967)2.09657996
162positive T cell selection (GO:0043368)2.09289420
163NLS-bearing protein import into nucleus (GO:0006607)2.08994395
164lipoprotein transport (GO:0042953)2.08788808

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.94407427
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.54826755
3MYC_22102868_ChIP-Seq_BL_Human3.09189119
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92769054
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.89181210
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.73550815
7VDR_21846776_ChIP-Seq_THP-1_Human2.40933202
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.29657448
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.28577483
10TCF7_22412390_ChIP-Seq_EML_Mouse2.27404263
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.20304038
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.19713422
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19401259
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13106097
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.11306184
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07790104
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06245880
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02658931
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.01973852
20KDM2B_26808549_Chip-Seq_DND41_Human2.00256551
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95057809
22MAF_26560356_Chip-Seq_TH1_Human1.94564908
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.94391897
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92781783
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.90044129
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.88105164
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87538685
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.86510585
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.81295602
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79865085
31UTX_26944678_Chip-Seq_JUKART_Human1.79768437
32CLOCK_20551151_ChIP-Seq_293T_Human1.77188356
33LXR_22292898_ChIP-Seq_THP-1_Human1.76815695
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.75256992
35GATA1_22025678_ChIP-Seq_K562_Human1.74802747
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71965347
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67136098
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66201387
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65664000
40SPI1_23127762_ChIP-Seq_K562_Human1.65388228
41VDR_24763502_ChIP-Seq_THP-1_Human1.64976581
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61941111
43RUNX_20019798_ChIP-Seq_JUKART_Human1.60538918
44MYB_26560356_Chip-Seq_TH2_Human1.60316564
45SCL_19346495_ChIP-Seq_HPC-7_Human1.58505428
46MYB_26560356_Chip-Seq_TH1_Human1.57484916
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57024546
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.55705682
49E2F7_22180533_ChIP-Seq_HELA_Human1.53403154
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49932180
51RACK7_27058665_Chip-Seq_MCF-7_Human1.44793341
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.44685230
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44640168
54P68_20966046_ChIP-Seq_HELA_Human1.43882161
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43028304
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.42131246
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41927129
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41777674
59* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.41689089
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41544759
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41268736
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.37680620
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36537631
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.36135633
65SMC4_20622854_ChIP-Seq_HELA_Human1.35557862
66* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34683254
67NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.33812315
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33278844
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33046720
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32089487
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30028263
72BCOR_27268052_Chip-Seq_Bcells_Human1.29191801
73GATA6_25053715_ChIP-Seq_YYC3_Human1.28911482
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28781670
75ATF3_27146783_Chip-Seq_COLON_Human1.27956061
76* KDM2B_26808549_Chip-Seq_JURKAT_Human1.27677925
77SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26829398
78NCOR1_26117541_ChIP-Seq_K562_Human1.23049956
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.21830592
80FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.20111217
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19480468
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19294478
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18891405
84* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18845898
85ESR1_21235772_ChIP-Seq_MCF-7_Human1.18666882
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.18199452
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17920930
88BCL6_27268052_Chip-Seq_Bcells_Human1.17316375
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16878318
90GATA1_19941826_ChIP-Seq_K562_Human1.16737184
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16672012
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.16357086
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15436526
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14527917
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14472488
96GATA3_27048872_Chip-Seq_THYMUS_Human1.14412404
97* MAF_26560356_Chip-Seq_TH2_Human1.14015871
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13779082
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13358378
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12455407
101KDM2B_26808549_Chip-Seq_K562_Human1.10816225
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10472028
103PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09014529
104GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08801353
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07703636
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07139014
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05645339
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05526405
109* SPI1_23547873_ChIP-Seq_NB4_Human1.04700927
110NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04550800
111PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03952300
112TFEB_21752829_ChIP-Seq_HELA_Human1.03399407
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03260661
114RUNX1_27514584_Chip-Seq_MCF-7_Human1.02239235
115SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01863809
116HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01124311
117* FOXA2_19822575_ChIP-Seq_HepG2_Human1.00808741
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00778495
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00128551
120PU_27001747_Chip-Seq_BMDM_Mouse1.00061764
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99444359
122GATA2_19941826_ChIP-Seq_K562_Human0.97331729
123CREB1_26743006_Chip-Seq_LNCaP_Human0.97199427
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96001659
125* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95965339
126P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95878028
127SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95855053
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95315755
129* TP63_22573176_ChIP-Seq_HFKS_Human0.95197947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.30596436
2MP0003705_abnormal_hypodermis_morpholog3.03745528
3MP0010234_abnormal_vibrissa_follicle2.79641299
4MP0005360_urolithiasis2.74623089
5MP0000569_abnormal_digit_pigmentation2.73531304
6MP0009840_abnormal_foam_cell2.63501111
7MP0010352_gastrointestinal_tract_polyps2.54003902
8MP0005451_abnormal_body_composition2.44973604
9MP0003303_peritoneal_inflammation2.42703585
10MP0003724_increased_susceptibility_to2.36329687
11MP0008260_abnormal_autophagy2.27130136
12MP0003172_abnormal_lysosome_physiology2.13912652
13MP0005076_abnormal_cell_differentiation2.13163067
14MP0003436_decreased_susceptibility_to2.12148522
15MP0003183_abnormal_peptide_metabolism2.06090183
16MP0005058_abnormal_lysosome_morphology2.04058638
17MP0004947_skin_inflammation2.01924395
18MP0002139_abnormal_hepatobiliary_system1.97095526
19MP0005365_abnormal_bile_salt1.95224654
20MP0003566_abnormal_cell_adhesion1.94789322
21MP0000685_abnormal_immune_system1.91885237
22MP0008961_abnormal_basal_metabolism1.85962881
23MP0002166_altered_tumor_susceptibility1.84774181
24MP0001835_abnormal_antigen_presentation1.79991145
25MP0005464_abnormal_platelet_physiology1.79397696
26MP0003191_abnormal_cellular_cholesterol1.79273867
27MP0001873_stomach_inflammation1.78697458
28MP0002877_abnormal_melanocyte_morpholog1.70317752
29MP0004264_abnormal_extraembryonic_tissu1.70254993
30MP0002148_abnormal_hypersensitivity_rea1.64612846
31MP0010155_abnormal_intestine_physiology1.61949546
32MP0001800_abnormal_humoral_immune1.59436384
33MP0010329_abnormal_lipoprotein_level1.59303038
34MP0001666_abnormal_nutrient_absorption1.57931148
35MP0003252_abnormal_bile_duct1.56816118
36MP0009278_abnormal_bone_marrow1.54130916
37MP0005387_immune_system_phenotype1.48963440
38MP0001790_abnormal_immune_system1.48963440
39MP0005083_abnormal_biliary_tract1.48243815
40MP0010307_abnormal_tumor_latency1.48203072
41MP0005000_abnormal_immune_tolerance1.43974396
42MP0002452_abnormal_antigen_presenting1.43032724
43MP0003866_abnormal_defecation1.40093939
44MP0001849_ear_inflammation1.39329955
45MP0000609_abnormal_liver_physiology1.38872833
46MP0002419_abnormal_innate_immunity1.35728174
47MP0005671_abnormal_response_to1.34832384
48MP0005023_abnormal_wound_healing1.32984775
49MP0000604_amyloidosis1.31001816
50MP0002420_abnormal_adaptive_immunity1.31000900
51MP0005409_darkened_coat_color1.30839774
52MP0001819_abnormal_immune_cell1.30655162
53MP0002723_abnormal_immune_serum1.30384783
54MP0002006_tumorigenesis1.29872348
55MP0005025_abnormal_response_to1.29641982
56MP0000465_gastrointestinal_hemorrhage1.29531269
57MP0002396_abnormal_hematopoietic_system1.29265937
58MP0002398_abnormal_bone_marrow1.28164629
59MP0005085_abnormal_gallbladder_physiolo1.27917304
60MP0006082_CNS_inflammation1.27834783
61MP0003329_amyloid_beta_deposits1.26329455
62MP0001845_abnormal_inflammatory_respons1.26094362
63MP0003763_abnormal_thymus_physiology1.26076523
64MP0005397_hematopoietic_system_phenotyp1.24352164
65MP0001545_abnormal_hematopoietic_system1.24352164
66MP0004185_abnormal_adipocyte_glucose1.23648808
67MP0004381_abnormal_hair_follicle1.20759851
68MP0004858_abnormal_nervous_system1.20077215
69MP0002405_respiratory_system_inflammati1.19274943
70MP0009785_altered_susceptibility_to1.14861061
71MP0004510_myositis1.14665902
72MP0000716_abnormal_immune_system1.14028160
73MP0003453_abnormal_keratinocyte_physiol1.13279929
74MP0001533_abnormal_skeleton_physiology1.13045084
75MP0003091_abnormal_cell_migration1.12394110
76MP0004808_abnormal_hematopoietic_stem1.08722845
77MP0002722_abnormal_immune_system1.08621121
78MP0003828_pulmonary_edema1.06818537
79MP0000689_abnormal_spleen_morphology1.06079210
80MP0003045_fibrosis1.05705481
81MP0005310_abnormal_salivary_gland1.05232582
82MP0002933_joint_inflammation1.03767601
83MP0003279_aneurysm1.01754858
84MP0006054_spinal_hemorrhage1.00302360
85MP0001851_eye_inflammation1.00096245
86MP0000858_altered_metastatic_potential0.99983924
87MP0009643_abnormal_urine_homeostasis0.98265095
88MP0002429_abnormal_blood_cell0.98237999
89MP0003690_abnormal_glial_cell0.97383249
90MP0003075_altered_response_to0.97317747
91MP0008469_abnormal_protein_level0.97306486
92MP0003448_altered_tumor_morphology0.96407038
93MP0008875_abnormal_xenobiotic_pharmacok0.95445348
94MP0002796_impaired_skin_barrier0.94641814
95MP0000003_abnormal_adipose_tissue0.93363677
96MP0008004_abnormal_stomach_pH0.92909067
97MP0000678_abnormal_parathyroid_gland0.92431739
98MP0001348_abnormal_lacrimal_gland0.91414939
99MP0000598_abnormal_liver_morphology0.90801588
100MP0000703_abnormal_thymus_morphology0.90185115
101MP0002998_abnormal_bone_remodeling0.90103669
102MP0009333_abnormal_splenocyte_physiolog0.89090657
103MP0001853_heart_inflammation0.88832397
104MP0002138_abnormal_hepatobiliary_system0.88780891
105MP0002136_abnormal_kidney_physiology0.88262062
106MP0005375_adipose_tissue_phenotype0.88229875
107MP0002118_abnormal_lipid_homeostasis0.88070283
108MP0001663_abnormal_digestive_system0.87575460
109MP0004130_abnormal_muscle_cell0.87442985
110MP0009764_decreased_sensitivity_to0.87411940
111MP0005166_decreased_susceptibility_to0.87397788
112MP0000490_abnormal_crypts_of0.85584496
113MP0001881_abnormal_mammary_gland0.84565381
114MP0009780_abnormal_chondrocyte_physiolo0.84444026
115MP0005390_skeleton_phenotype0.83813172
116MP0005319_abnormal_enzyme/_coenzyme0.82699803
117MP0000249_abnormal_blood_vessel0.81786217
118MP0005666_abnormal_adipose_tissue0.81350692
119MP0002254_reproductive_system_inflammat0.78930338
120MP0001958_emphysema0.77991606
121MP0000477_abnormal_intestine_morphology0.77817153
122MP0000371_diluted_coat_color0.77282867
123MP0003795_abnormal_bone_structure0.72701882
124MP0000343_altered_response_to0.69303767
125MP0008874_decreased_physiological_sensi0.68809355

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)3.50847726
2Cerebral aneurysm (HP:0004944)2.84747125
3Malnutrition (HP:0004395)2.68282815
4Mediastinal lymphadenopathy (HP:0100721)2.67807429
5Hand muscle atrophy (HP:0009130)2.67571736
6Eczematoid dermatitis (HP:0000976)2.67492520
7Obstructive sleep apnea (HP:0002870)2.63229515
8Increased cerebral lipofuscin (HP:0011813)2.60522385
9Broad face (HP:0000283)2.59879233
10Dysostosis multiplex (HP:0000943)2.59610385
11Orchitis (HP:0100796)2.54599250
12Urinary glycosaminoglycan excretion (HP:0003541)2.53240647
13Mucopolysacchariduria (HP:0008155)2.53240647
14Obstructive lung disease (HP:0006536)2.51806095
15Chronic obstructive pulmonary disease (HP:0006510)2.51806095
16Myocardial infarction (HP:0001658)2.49535655
17Autoimmune thrombocytopenia (HP:0001973)2.49201336
18Spontaneous hematomas (HP:0007420)2.48860478
19Hemorrhage of the eye (HP:0011885)2.48235179
20Recurrent viral infections (HP:0004429)2.46722835
21Recurrent fungal infections (HP:0002841)2.44228932
22Meningitis (HP:0001287)2.41833290
23Upper limb amyotrophy (HP:0009129)2.41448783
24Distal upper limb amyotrophy (HP:0007149)2.41448783
25Pustule (HP:0200039)2.40790147
26Abnormality of polysaccharide metabolism (HP:0011012)2.39924203
27Abnormality of glycosaminoglycan metabolism (HP:0004371)2.39924203
28Abnormality of mucopolysaccharide metabolism (HP:0011020)2.39924203
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.36989483
30Interstitial pulmonary disease (HP:0006530)2.33734297
31Colitis (HP:0002583)2.29949947
32Gastrointestinal stroma tumor (HP:0100723)2.29152457
33Periodontitis (HP:0000704)2.26040196
34Gastrointestinal infarctions (HP:0005244)2.25865219
35Macroorchidism (HP:0000053)2.25810587
36Recurrent gram-negative bacterial infections (HP:0005420)2.25779585
37Aortic aneurysm (HP:0004942)2.24883583
38Hyperacusis (HP:0010780)2.21515122
39J-shaped sella turcica (HP:0002680)2.19589188
40Deep venous thrombosis (HP:0002625)2.19134676
41Recurrent bacterial skin infections (HP:0005406)2.18868741
42Emphysema (HP:0002097)2.18269899
43Gastrointestinal inflammation (HP:0004386)2.16810998
44Vasculitis (HP:0002633)2.16251619
45Flat acetabular roof (HP:0003180)2.12853743
46Aneurysm (HP:0002617)2.10748167
47Optic neuritis (HP:0100653)2.10584695
48Retrobulbar optic neuritis (HP:0100654)2.10584695
49Distal lower limb amyotrophy (HP:0008944)2.09569885
50Inflammation of the large intestine (HP:0002037)2.09350383
51Abnormality of the thoracic spine (HP:0100711)2.09180629
52Elevated erythrocyte sedimentation rate (HP:0003565)2.08481330
53Hematochezia (HP:0002573)2.08022106
54Neuronal loss in central nervous system (HP:0002529)2.07992350
55Xanthomatosis (HP:0000991)2.06401093
56Polygenic inheritance (HP:0010982)2.05941012
57Recurrent abscess formation (HP:0002722)2.02881498
58Abnormality of the fingertips (HP:0001211)2.01449454
59Slow saccadic eye movements (HP:0000514)2.00787693
60T lymphocytopenia (HP:0005403)1.99786847
61Spastic diplegia (HP:0001264)1.99515053
62Prolonged bleeding time (HP:0003010)1.98776794
63Long toe (HP:0010511)1.93967891
64Purpura (HP:0000979)1.93800632
65Systemic lupus erythematosus (HP:0002725)1.93776444
66Restrictive lung disease (HP:0002091)1.92887221
67Esophageal varix (HP:0002040)1.92133968
68Complement deficiency (HP:0004431)1.91667514
69Abnormal delayed hypersensitivity skin test (HP:0002963)1.91408841
70Impaired platelet aggregation (HP:0003540)1.89862641
71Abnormal platelet function (HP:0011869)1.89862641
72Dilatation of the ascending aorta (HP:0005111)1.89354207
73Thoracic kyphosis (HP:0002942)1.89222214
74Increased neuronal autofluorescent lipopigment (HP:0002074)1.89206266
75Increased CSF protein (HP:0002922)1.89176171
76Epistaxis (HP:0000421)1.88648934
77Hemoptysis (HP:0002105)1.88582795
78Abnormality of glutamine family amino acid metabolism (HP:0010902)1.87269034
79Abnormal platelet volume (HP:0011876)1.86256846
80Neurofibrillary tangles (HP:0002185)1.86239575
81Urticaria (HP:0001025)1.85914492
82Subacute progressive viral hepatitis (HP:0006572)1.85730059
83Segmental peripheral demyelination/remyelination (HP:0003481)1.85711094
84Nasal polyposis (HP:0100582)1.85575810
85Osteomyelitis (HP:0002754)1.85412934
86Gingivitis (HP:0000230)1.85139202
87Severe short stature (HP:0003510)1.84759290
88Abnormality of T cell number (HP:0011839)1.84654202
89Cellulitis (HP:0100658)1.84403471
90Mitral stenosis (HP:0001718)1.84391754
91Mitral valve prolapse (HP:0001634)1.83871933
92Polycythemia (HP:0001901)1.83792911
93Increased density of long bones (HP:0006392)1.83695434
94Cervical subluxation (HP:0003308)1.82894787
95Axonal loss (HP:0003447)1.82490916
96Amyloidosis (HP:0011034)1.81826447
97Loss of speech (HP:0002371)1.81747255
98Heterotopia (HP:0002282)1.81464200
99Increased mean platelet volume (HP:0011877)1.81218971
100Pulmonary infiltrates (HP:0002113)1.81028154
101Vacuolated lymphocytes (HP:0001922)1.81021178
102Frequent falls (HP:0002359)1.80918409
103Gingival bleeding (HP:0000225)1.79898489
104Chronic otitis media (HP:0000389)1.79711840
105Increased connective tissue (HP:0009025)1.79405418
106Striae distensae (HP:0001065)1.78510376
107Fatigue (HP:0012378)1.77904387
108Distal lower limb muscle weakness (HP:0009053)1.77783913
109Premature loss of primary teeth (HP:0006323)1.77126350
110Agammaglobulinemia (HP:0004432)1.76582924
111Radial bowing (HP:0002986)1.76443258
112Glomerulonephritis (HP:0000099)1.76102691
113Increased serum ferritin (HP:0003281)1.75950184
114Centrally nucleated skeletal muscle fibers (HP:0003687)1.75018299
115Bone pain (HP:0002653)1.74906524
116Chest pain (HP:0100749)1.73865072
117Supranuclear gaze palsy (HP:0000605)1.73600641
118Osteolytic defects of the hand bones (HP:0009699)1.73469477
119Osteolytic defects of the phalanges of the hand (HP:0009771)1.73469477
120Verrucae (HP:0200043)1.73236381
121Papilloma (HP:0012740)1.73236381
122Vertebral compression fractures (HP:0002953)1.72875380
123Arterial thrombosis (HP:0004420)1.72694064
124Abnormality of the common coagulation pathway (HP:0010990)1.71102977
125Thin bony cortex (HP:0002753)1.70586266
126Abnormality of complement system (HP:0005339)1.70517170
127Cerebral inclusion bodies (HP:0100314)1.70473945
128Abnormality of monocarboxylic acid metabolism (HP:0010996)1.70304512
129Petechiae (HP:0000967)1.69915574
130Global brain atrophy (HP:0002283)1.69434943
131Increased IgE level (HP:0003212)1.68868962
132Coarse hair (HP:0002208)1.68438226
133Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.67387100
134Abnormality of oral frenula (HP:0000190)1.66778454
135Abnormality of the nasal mucosa (HP:0000433)1.66702110
136Disproportionate tall stature (HP:0001519)1.66120895
137Pseudobulbar signs (HP:0002200)1.65880939
138Abnormality of glycolipid metabolism (HP:0010969)1.65674942
139Abnormality of liposaccharide metabolism (HP:0010968)1.65674942
140Abnormality of glycosphingolipid metabolism (HP:0004343)1.65674942
141Recurrent skin infections (HP:0001581)1.64847604
142Enlarged penis (HP:0000040)1.64519910
143Upper motor neuron abnormality (HP:0002127)1.63844851
144Abnormality of the lower motor neuron (HP:0002366)1.63833376
145Ulnar bowing (HP:0003031)1.63312308
146Chronic mucocutaneous candidiasis (HP:0002728)1.60386100
147Recurrent cutaneous fungal infections (HP:0011370)1.60386100
148Abdominal distention (HP:0003270)1.56956052
149Thrombocytosis (HP:0001894)1.56619252
150Micronodular cirrhosis (HP:0001413)1.54893825
151Myositis (HP:0100614)1.54842387

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.75894565
2ERN13.70453307
3PRPF4B3.23637329
4PKN23.13562651
5MAP4K12.75036591
6EEF2K2.69719729
7CDK122.53336016
8SMG12.42598158
9MAP3K102.41651927
10SIK12.18692029
11PTK62.06958194
12IRAK32.04022420
13FGFR41.92604019
14SCYL21.90550135
15ZAP701.77403337
16STK101.76318245
17TYK21.75978921
18RIPK11.72309569
19TAOK31.68196882
20CAMK1D1.62465936
21JAK11.54300629
22JAK31.50610011
23GRK61.48795334
24LRRK21.46321563
25TBK11.45193359
26CDC42BPA1.43120414
27MARK21.40865592
28SIK21.37824007
29EPHB11.36623257
30CAMK1G1.32005534
31PDGFRA1.31717494
32CDK61.30623009
33ITK1.28579221
34TNK21.27628519
35FES1.23479813
36FGFR31.22555673
37PRKD21.16720314
38TAOK11.15773949
39TTN1.14087735
40MAP2K31.13583202
41RIPK41.11904779
42BMX1.11222238
43TAOK21.11045707
44HCK1.06568940
45CAMKK11.05877654
46JAK21.05588487
47MAP3K131.03808578
48ALK1.00592173
49PTK20.99399421
50BTK0.98546142
51KSR20.96706218
52PAK40.94588912
53CSK0.93416443
54PDGFRB0.93344070
55TGFBR20.92980915
56CSF1R0.89518151
57MTOR0.89061638
58ICK0.88356040
59FRK0.87898898
60RET0.87244291
61IKBKE0.85638038
62TESK20.85562662
63BLK0.82064486
64FLT30.81393984
65FGR0.79399005
66CHUK0.79322031
67RPS6KL10.78932947
68RPS6KC10.78932947
69MAP3K60.77778916
70PRKCH0.76089070
71SIK30.74142154
72MAP3K140.73794031
73KIT0.73712135
74MAP3K70.73016942
75CDK40.72794484
76RPS6KB20.72589415
77MAP3K90.72543333
78EPHA20.70537242
79SYK0.69607691
80NME20.68620538
81LCK0.66266690
82MAP2K20.66119477
83MARK30.64723569
84DYRK1B0.64670293
85MAP3K20.64606445
86MAP3K80.64424381
87TESK10.64245029
88RPS6KA40.64076094
89PAK20.62721941
90SGK30.62156362
91CDK90.61160610
92RPS6KA60.60851027
93MAP3K30.59307331
94MATK0.59141205
95PDK10.58788323
96MAPK120.58666173
97DDR20.58048959
98PIM10.57837553
99FGFR10.57735306
100TYRO30.57265862
101MAPK70.57211585
102LYN0.56811398
103TXK0.55832456
104PASK0.55775310
105MAPKAPK30.55741758
106MAP3K10.55357633
107IRAK20.54258877
108LATS10.53524288
109EGFR0.52211413
110NEK20.50237625
111STK380.50018303
112MAPK110.49749366
113PRKG20.48834336
114ERBB20.48437070
115BRD40.47718605
116PDPK10.47224506
117HIPK20.46909552
118MAP3K110.46404188
119MAP2K60.44843166
120LMTK20.43478269
121DAPK20.42541573
122IKBKB0.42460066
123STK30.39661273
124RPS6KA20.39637832
125FYN0.38976095
126IRAK40.38722735
127MST1R0.38374663

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.55175119
2Chronic myeloid leukemia_Homo sapiens_hsa052201.67654399
3Caffeine metabolism_Homo sapiens_hsa002321.62000258
4B cell receptor signaling pathway_Homo sapiens_hsa046621.61049935
5Allograft rejection_Homo sapiens_hsa053301.60349166
6Graft-versus-host disease_Homo sapiens_hsa053321.57590771
7Leishmaniasis_Homo sapiens_hsa051401.57258773
8Osteoclast differentiation_Homo sapiens_hsa043801.57239953
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48397905
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47526374
11Autoimmune thyroid disease_Homo sapiens_hsa053201.46518971
12Staphylococcus aureus infection_Homo sapiens_hsa051501.45056644
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44679803
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39697683
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.36081160
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30992206
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28586912
18Lysine degradation_Homo sapiens_hsa003101.27981409
19Acute myeloid leukemia_Homo sapiens_hsa052211.22591481
20Primary immunodeficiency_Homo sapiens_hsa053401.22026588
21Arginine biosynthesis_Homo sapiens_hsa002201.21863006
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21778505
23T cell receptor signaling pathway_Homo sapiens_hsa046601.20197842
24mTOR signaling pathway_Homo sapiens_hsa041501.19984681
25Insulin resistance_Homo sapiens_hsa049311.19609345
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18990153
27Toxoplasmosis_Homo sapiens_hsa051451.18843579
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.17633467
29Lysosome_Homo sapiens_hsa041421.17611802
30Antigen processing and presentation_Homo sapiens_hsa046121.16144424
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.15352107
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15046049
33Bile secretion_Homo sapiens_hsa049761.13877498
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.11561523
35Non-small cell lung cancer_Homo sapiens_hsa052231.10628002
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10123570
37Pancreatic cancer_Homo sapiens_hsa052121.09284608
38Measles_Homo sapiens_hsa051621.08469562
39Asthma_Homo sapiens_hsa053101.04457055
40Type I diabetes mellitus_Homo sapiens_hsa049401.04267047
41Malaria_Homo sapiens_hsa051441.04144278
42Fat digestion and absorption_Homo sapiens_hsa049751.03962458
43Tuberculosis_Homo sapiens_hsa051521.03184956
44Type II diabetes mellitus_Homo sapiens_hsa049301.02087785
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01514549
46VEGF signaling pathway_Homo sapiens_hsa043701.00456006
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.00157915
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.00078141
49Shigellosis_Homo sapiens_hsa051310.98141723
50Influenza A_Homo sapiens_hsa051640.97676153
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.96736220
52GnRH signaling pathway_Homo sapiens_hsa049120.94062993
53Apoptosis_Homo sapiens_hsa042100.93375022
54Hematopoietic cell lineage_Homo sapiens_hsa046400.92977395
55Renal cell carcinoma_Homo sapiens_hsa052110.92517397
56Prion diseases_Homo sapiens_hsa050200.90839588
57Hepatitis B_Homo sapiens_hsa051610.89637637
58Proteoglycans in cancer_Homo sapiens_hsa052050.89305106
59Small cell lung cancer_Homo sapiens_hsa052220.88627520
60Endometrial cancer_Homo sapiens_hsa052130.88138553
61TNF signaling pathway_Homo sapiens_hsa046680.87803538
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.87473252
63Prolactin signaling pathway_Homo sapiens_hsa049170.87216822
64Complement and coagulation cascades_Homo sapiens_hsa046100.85923908
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85824874
66ABC transporters_Homo sapiens_hsa020100.85821011
67Platelet activation_Homo sapiens_hsa046110.85432304
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85220304
69Glioma_Homo sapiens_hsa052140.85128973
70Fructose and mannose metabolism_Homo sapiens_hsa000510.85117919
71Choline metabolism in cancer_Homo sapiens_hsa052310.84681146
72PPAR signaling pathway_Homo sapiens_hsa033200.84250269
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83511400
74Hepatitis C_Homo sapiens_hsa051600.83013469
75Selenocompound metabolism_Homo sapiens_hsa004500.81630762
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.81356484
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81062218
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80207146
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.79897943
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.79500366
81Amoebiasis_Homo sapiens_hsa051460.79232377
82Chemokine signaling pathway_Homo sapiens_hsa040620.78260211
83Phagosome_Homo sapiens_hsa041450.78075610
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77788030
85ErbB signaling pathway_Homo sapiens_hsa040120.76423300
86Rheumatoid arthritis_Homo sapiens_hsa053230.76349630
87Bladder cancer_Homo sapiens_hsa052190.76337911
88Legionellosis_Homo sapiens_hsa051340.75554117
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74122681
90Pertussis_Homo sapiens_hsa051330.71513186
91Endocytosis_Homo sapiens_hsa041440.69823752
92Adherens junction_Homo sapiens_hsa045200.69786659
93Tryptophan metabolism_Homo sapiens_hsa003800.69651338
94Renin-angiotensin system_Homo sapiens_hsa046140.69072880
95Estrogen signaling pathway_Homo sapiens_hsa049150.68515132
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67513903
97African trypanosomiasis_Homo sapiens_hsa051430.66831865
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66814054
99Salmonella infection_Homo sapiens_hsa051320.66218755
100Focal adhesion_Homo sapiens_hsa045100.63565305
101Other glycan degradation_Homo sapiens_hsa005110.63561074
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63528112
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63206722
104HTLV-I infection_Homo sapiens_hsa051660.62436600
105Pentose phosphate pathway_Homo sapiens_hsa000300.61849167
106Insulin signaling pathway_Homo sapiens_hsa049100.61784882
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61647013
108MicroRNAs in cancer_Homo sapiens_hsa052060.61600057
109Glycerolipid metabolism_Homo sapiens_hsa005610.60959618
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60557070
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.60401667
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.60188414
113Viral myocarditis_Homo sapiens_hsa054160.59647931
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.58590060
115Herpes simplex infection_Homo sapiens_hsa051680.58354933
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57774729
117Colorectal cancer_Homo sapiens_hsa052100.57773230
118HIF-1 signaling pathway_Homo sapiens_hsa040660.57744210
119AMPK signaling pathway_Homo sapiens_hsa041520.57737897
120Viral carcinogenesis_Homo sapiens_hsa052030.57593247
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57243065
122Galactose metabolism_Homo sapiens_hsa000520.56803056
123Prostate cancer_Homo sapiens_hsa052150.56291967
124Fatty acid degradation_Homo sapiens_hsa000710.55991186
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53004913
126Epstein-Barr virus infection_Homo sapiens_hsa051690.52782112
127Notch signaling pathway_Homo sapiens_hsa043300.52420610
128Inositol phosphate metabolism_Homo sapiens_hsa005620.52199486
129Thyroid cancer_Homo sapiens_hsa052160.51075312
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.50747897
131FoxO signaling pathway_Homo sapiens_hsa040680.49256887

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