GAL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Galanin has diverse physiological functions including nociception, feeding and energy homeostasis, osmotic regulation and water balance. GMAP has been demonstrated to possess antifungal activity and hypothesized to be part of the innate immune system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chemosensory behavior (GO:0007635)8.63356599
2urinary tract smooth muscle contraction (GO:0014848)7.12775230
3drinking behavior (GO:0042756)6.66745074
4sympathetic nervous system development (GO:0048485)6.61223643
5response to ATP (GO:0033198)6.29336537
6peristalsis (GO:0030432)6.23787259
7negative regulation of digestive system process (GO:0060457)5.83534595
8positive regulation of vascular permeability (GO:0043117)5.75365191
9response to pain (GO:0048265)5.44610003
10phenol-containing compound catabolic process (GO:0019336)5.37141772
11heterochromatin organization (GO:0070828)5.34825377
12activation of protein kinase A activity (GO:0034199)5.34351551
13ribosomal small subunit biogenesis (GO:0042274)5.31717611
14neuromuscular synaptic transmission (GO:0007274)5.15347395
15negative regulation of cell size (GO:0045792)5.06632953
16negative regulation of appetite (GO:0032099)4.93500049
17negative regulation of response to food (GO:0032096)4.93500049
18negative regulation of microtubule polymerization (GO:0031115)4.92000499
19regulation of feeding behavior (GO:0060259)4.75588066
20DNA replication checkpoint (GO:0000076)4.68073342
21maturation of SSU-rRNA (GO:0030490)4.54381760
22regulation of response to food (GO:0032095)4.24869895
23protein complex localization (GO:0031503)4.18218365
24behavioral response to pain (GO:0048266)4.14822019
25phasic smooth muscle contraction (GO:0014821)4.10921642
26L-serine metabolic process (GO:0006563)4.09834714
27* positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.99108962
28regulation of mitochondrial translation (GO:0070129)3.98523420
29DNA unwinding involved in DNA replication (GO:0006268)3.97318400
30behavioral response to nicotine (GO:0035095)3.96094640
31proteasome assembly (GO:0043248)3.96006180
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.90772903
33DNA strand elongation involved in DNA replication (GO:0006271)3.89903584
34IMP biosynthetic process (GO:0006188)3.86754353
35DNA strand elongation (GO:0022616)3.80597421
36purine nucleobase biosynthetic process (GO:0009113)3.79514759
37negative regulation of dendrite morphogenesis (GO:0050774)3.79024987
38ribonucleoprotein complex biogenesis (GO:0022613)3.76576182
39nucleobase biosynthetic process (GO:0046112)3.74997064
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.73690333
41histone arginine methylation (GO:0034969)3.72044049
42pseudouridine synthesis (GO:0001522)3.70176056
43proline transport (GO:0015824)3.66967975
44cellular protein complex localization (GO:0034629)3.66905845
45oxidative phosphorylation (GO:0006119)3.63506916
46formation of translation preinitiation complex (GO:0001731)3.60891160
47L-serine transport (GO:0015825)3.59964764
48peptide cross-linking (GO:0018149)3.59923212
49DNA replication initiation (GO:0006270)3.57522858
50pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.55190839
51transcription from mitochondrial promoter (GO:0006390)3.53487792
52regulation of appetite (GO:0032098)3.53148957
53neurotransmitter catabolic process (GO:0042135)3.52957651
54telomere maintenance via semi-conservative replication (GO:0032201)3.52693636
55regulation of translational fidelity (GO:0006450)3.52471746
56rRNA processing (GO:0006364)3.51360752
57neuronal action potential (GO:0019228)3.51359193
58negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.51242042
59nucleobase-containing small molecule interconversion (GO:0015949)3.49939359
60establishment of integrated proviral latency (GO:0075713)3.48888660
61ribosome assembly (GO:0042255)3.48662390
62regulation of translational termination (GO:0006449)3.48271624
63protein localization to chromosome, centromeric region (GO:0071459)3.45417284
64ribosome biogenesis (GO:0042254)3.44627429
65IMP metabolic process (GO:0046040)3.44433523
66protein targeting to mitochondrion (GO:0006626)3.44397207
67protein localization to kinetochore (GO:0034501)3.43853032
68energy coupled proton transport, down electrochemical gradient (GO:0015985)3.43804289
69ATP synthesis coupled proton transport (GO:0015986)3.43804289
70ribosomal large subunit biogenesis (GO:0042273)3.43418963
71pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.41894225
72viral transcription (GO:0019083)3.41424675
73regulation of amyloid precursor protein catabolic process (GO:1902991)3.35453771
74multicellular organismal response to stress (GO:0033555)3.34272268
75regulation of synapse structural plasticity (GO:0051823)3.32428422
76spliceosomal snRNP assembly (GO:0000387)3.31419764
77negative regulation of necrotic cell death (GO:0060547)3.30984335
78negative regulation of RNA splicing (GO:0033119)3.30726107
79rRNA metabolic process (GO:0016072)3.30498224
80translational termination (GO:0006415)3.28236970
81positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.27316601
82regulation of protein kinase A signaling (GO:0010738)3.26625902
83protein localization to synapse (GO:0035418)3.26293586
84negative regulation of mRNA processing (GO:0050686)3.25830581
85detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.25442769
86detection of temperature stimulus involved in sensory perception (GO:0050961)3.25442769
87proline biosynthetic process (GO:0006561)3.23302385
88chromatin remodeling at centromere (GO:0031055)3.22722582
89DNA damage response, detection of DNA damage (GO:0042769)3.22255544
90pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.21892310
91response to water (GO:0009415)3.21285958
92negative regulation of ligase activity (GO:0051352)3.20559659
93negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.20559659
94protein neddylation (GO:0045116)3.20291847
95establishment of protein localization to mitochondrial membrane (GO:0090151)3.18283986
96enteric nervous system development (GO:0048484)3.17763417
97synaptic vesicle exocytosis (GO:0016079)3.17758113
98outer ear morphogenesis (GO:0042473)3.13299073
99synaptic vesicle maturation (GO:0016188)3.13081999
100deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.12721296
101peptidyl-arginine omega-N-methylation (GO:0035247)3.12291767
102UTP biosynthetic process (GO:0006228)3.12087466
103negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12081281
104CENP-A containing nucleosome assembly (GO:0034080)3.11280451
105establishment of protein localization to mitochondrion (GO:0072655)3.11110038
106mitotic metaphase plate congression (GO:0007080)3.10901524
107cell migration in hindbrain (GO:0021535)3.08685746
108serine transport (GO:0032329)3.08661927
109cellular response to alkaloid (GO:0071312)3.08410490
110neurotransmitter secretion (GO:0007269)3.07694372
111regulation of synaptic vesicle exocytosis (GO:2000300)3.06975678
112detection of temperature stimulus (GO:0016048)3.06626066
113vocalization behavior (GO:0071625)3.04813460
114neuron cell-cell adhesion (GO:0007158)3.04544118
115cellular component biogenesis (GO:0044085)3.04317264
116translation (GO:0006412)3.04058254
117positive regulation of calcium ion import (GO:0090280)3.03898661
118regulation of nuclear cell cycle DNA replication (GO:0033262)3.03486490
119translational elongation (GO:0006414)3.03441832
120regulation of short-term neuronal synaptic plasticity (GO:0048172)3.00987210
121ribosomal small subunit assembly (GO:0000028)3.00754247
122protein maturation by protein folding (GO:0022417)3.00632613
123translational initiation (GO:0006413)2.99486815
124maturation of 5.8S rRNA (GO:0000460)2.98893744
125negative regulation of mRNA metabolic process (GO:1903312)2.97157585
126mitochondrial RNA metabolic process (GO:0000959)2.95915627
127anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95411049
128SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.95019246
129peripheral nervous system development (GO:0007422)2.94932612
130CTP metabolic process (GO:0046036)2.94771648
131CTP biosynthetic process (GO:0006241)2.94771648
132peptidyl-histidine modification (GO:0018202)2.94508895
133termination of RNA polymerase III transcription (GO:0006386)2.93194356
134transcription elongation from RNA polymerase III promoter (GO:0006385)2.93194356
135regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.93176549
136nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.93094554
137pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.92552358
138protein localization to mitochondrion (GO:0070585)2.92384110
139guanosine-containing compound biosynthetic process (GO:1901070)2.91782968
140energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.91676357
141ATP hydrolysis coupled proton transport (GO:0015991)2.91676357
142viral mRNA export from host cell nucleus (GO:0046784)2.91559137
143regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91429459
144respiratory system process (GO:0003016)2.91227829
145folic acid-containing compound biosynthetic process (GO:0009396)2.90406278
146regulation of endothelial cell chemotaxis (GO:2001026)2.90343355
147regulation of mammary gland epithelial cell proliferation (GO:0033599)2.89943041
148synaptic transmission, cholinergic (GO:0007271)2.89229469
149nuclear pore complex assembly (GO:0051292)2.88381817
150regulation of vesicle fusion (GO:0031338)2.88201102
151neurotransmitter transport (GO:0006836)2.87144240
152cotranslational protein targeting to membrane (GO:0006613)2.86346377
153positive regulation of SMAD protein import into nucleus (GO:0060391)2.86321570
154positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.85692281
155mitotic sister chromatid segregation (GO:0000070)2.84996498
156alanine transport (GO:0032328)2.84781559
157protein targeting to ER (GO:0045047)2.84353391
158telomere maintenance via recombination (GO:0000722)2.80305457
159negative regulation of telomerase activity (GO:0051974)2.79808618
160termination of RNA polymerase II transcription (GO:0006369)2.78688638
161ncRNA 3-end processing (GO:0043628)2.76399034
162chromatin assembly (GO:0031497)2.75651375
163maternal behavior (GO:0042711)2.73958240
164sensory perception of taste (GO:0050909)2.72814795
165regulation of synaptic transmission, glutamatergic (GO:0051966)2.71075415
166glutamate secretion (GO:0014047)2.70986105
167purinergic nucleotide receptor signaling pathway (GO:0035590)2.66611739
168negative regulation of dendrite development (GO:2000171)2.64033099
169positive regulation of growth hormone secretion (GO:0060124)2.63140255
170positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.60535316
171calcium-mediated signaling using intracellular calcium source (GO:0035584)2.59858222
172positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.58114713
173catecholamine transport (GO:0051937)2.57728748
174negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.56879346
175negative regulation of response to extracellular stimulus (GO:0032105)2.56550562
176negative regulation of response to nutrient levels (GO:0032108)2.56550562
177locomotory exploration behavior (GO:0035641)2.52971858
178regulation of digestive system process (GO:0044058)2.52606177
179neuromuscular process controlling posture (GO:0050884)2.52137089
180neurofilament cytoskeleton organization (GO:0060052)2.51460549
181regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.50822141
182nucleobase catabolic process (GO:0046113)2.50770277
183response to nerve growth factor (GO:1990089)2.50326273
184cellular response to nerve growth factor stimulus (GO:1990090)2.50326273
185plasma membrane repair (GO:0001778)2.49313522
186cellular response to nicotine (GO:0071316)2.48764155
187behavioral response to ethanol (GO:0048149)2.46248007
188regulation of neurotransmitter levels (GO:0001505)2.45416953
189regulation of synaptic vesicle transport (GO:1902803)2.45255959
190cytidine deamination (GO:0009972)2.44013314
191cytidine metabolic process (GO:0046087)2.44013314
192cytidine catabolic process (GO:0006216)2.44013314
193oxygen transport (GO:0015671)2.43654384
194chaperone-mediated protein transport (GO:0072321)2.41062809
195* positive regulation of potassium ion transmembrane transport (GO:1901381)2.40545228
196fear response (GO:0042596)2.38915468
197layer formation in cerebral cortex (GO:0021819)2.37478150
198cellular response to ATP (GO:0071318)13.5557160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.75487401
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.49658605
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.37105815
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.07840021
5EZH2_22144423_ChIP-Seq_EOC_Human3.97536942
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.93502159
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.41579328
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.25495023
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.22097544
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.10679711
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse3.01889484
12MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00421328
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98807417
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95652772
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90680774
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85282267
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.81635609
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.73274130
19XRN2_22483619_ChIP-Seq_HELA_Human2.64752041
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62893963
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62893963
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60759480
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59293793
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58945451
25REST_21632747_ChIP-Seq_MESCs_Mouse2.57156617
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54449237
27TAF15_26573619_Chip-Seq_HEK293_Human2.53371509
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51492860
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.46259508
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44986349
31ETS1_20019798_ChIP-Seq_JURKAT_Human2.44742016
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.41071127
33REST_18959480_ChIP-ChIP_MESCs_Mouse2.38101813
34E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34671505
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28354167
36NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27243668
37JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25272780
38AR_21572438_ChIP-Seq_LNCaP_Human2.23470406
39CDX2_19796622_ChIP-Seq_MESCs_Mouse2.22831447
40E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22818878
41EZH2_27304074_Chip-Seq_ESCs_Mouse2.20814079
42DCP1A_22483619_ChIP-Seq_HELA_Human2.19844335
43GABP_17652178_ChIP-ChIP_JURKAT_Human2.13096741
44* NR3C1_23031785_ChIP-Seq_PC12_Mouse2.10274807
45EZH2_27294783_Chip-Seq_ESCs_Mouse2.09049949
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07581594
47GBX2_23144817_ChIP-Seq_PC3_Human2.03320111
48EED_16625203_ChIP-ChIP_MESCs_Mouse2.00158107
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.98309448
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96305995
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95525367
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.94307959
53TTF2_22483619_ChIP-Seq_HELA_Human1.93393564
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.92439451
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91939453
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90109705
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88410101
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.84125617
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79537142
60IGF1R_20145208_ChIP-Seq_DFB_Human1.79289381
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.77711896
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.77427451
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75119130
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75119130
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75119130
66GABP_19822575_ChIP-Seq_HepG2_Human1.75040625
67AR_21909140_ChIP-Seq_LNCAP_Human1.72215287
68DROSHA_22980978_ChIP-Seq_HELA_Human1.72172901
69ZNF274_21170338_ChIP-Seq_K562_Hela1.68974782
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.65176382
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.63055522
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60453637
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.59182684
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53134320
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52975474
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52579482
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51032730
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51030760
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50769897
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49993492
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.46710663
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.46601800
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.45844129
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44708262
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44008377
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.43992056
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43895068
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43393899
89CLOCK_20551151_ChIP-Seq_293T_Human1.40696274
90RARB_27405468_Chip-Seq_BRAIN_Mouse1.40008953
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39406060
92FOXP3_21729870_ChIP-Seq_TREG_Human1.38932332
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36318693
94KDM5A_27292631_Chip-Seq_BREAST_Human1.36255658
95MYC_22102868_ChIP-Seq_BL_Human1.36171916
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34891999
97CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.34719019
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34516446
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34436793
100ESR2_21235772_ChIP-Seq_MCF-7_Human1.33300235
101SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32752871
102STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32591508
103* CTCF_27219007_Chip-Seq_Bcells_Human1.30965985
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30570368
105P300_19829295_ChIP-Seq_ESCs_Human1.29790483
106* AR_25329375_ChIP-Seq_VCAP_Human1.28825878
107ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28108706
108OCT4_18692474_ChIP-Seq_MEFs_Mouse1.26368913
109ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25725408
110TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25181197
111KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22480300
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21405299
113SMAD4_21799915_ChIP-Seq_A2780_Human1.21104306
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21067227
115MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21031149
116TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.20567839
117CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20108136
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19950017
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19651272
120IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19528826
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17344125
122* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16063248
123TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15469303
124HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15160362
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14532846
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14513363
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13061171
128VDR_21846776_ChIP-Seq_THP-1_Human1.12932295
129SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12639717
130SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12295405
131NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11748144
132FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10730316
133SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10588461
134TET1_21451524_ChIP-Seq_MESCs_Mouse1.10560132
135HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10360371
136ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10259730
137CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09697881
138VDR_23849224_ChIP-Seq_CD4+_Human1.08906722
139SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08623587
140SRF_21415370_ChIP-Seq_HL-1_Mouse1.07934482
141EP300_21415370_ChIP-Seq_HL-1_Mouse1.07810153
142RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07527186
143TP63_19390658_ChIP-ChIP_HaCaT_Human1.07319766
144CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06690171
145KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06387956
146* SOX2_20726797_ChIP-Seq_SW620_Human1.06309734
147SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06156833
148PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05425052
149SOX2_21211035_ChIP-Seq_LN229_Gbm1.04562366
150SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04529583
151KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04343517
152EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03885919
153TFEB_21752829_ChIP-Seq_HELA_Human1.03867559
154CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03212373
155ZNF263_19887448_ChIP-Seq_K562_Human1.03024885
156ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02940464
157HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02693755
158CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01311315
159SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00890598
160RING1B_27294783_Chip-Seq_ESCs_Mouse0.99616205
161TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99426930
162PIAS1_25552417_ChIP-Seq_VCAP_Human0.99093702
163RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99010361
164JUN_21703547_ChIP-Seq_K562_Human0.98456582
165* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96783391
166FOXP1_21924763_ChIP-Seq_HESCs_Human0.96296378
167STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95911111
168TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95347951
169LXR_22292898_ChIP-Seq_THP-1_Human0.95198072
170PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94466854
171TET1_21490601_ChIP-Seq_MESCs_Mouse0.92862504
172WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92666358
173POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92066318
174THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91738965
175SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91457368
176ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91189038
177* NCOR_22424771_ChIP-Seq_293T_Human0.89975739
178* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89383886
179* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.86898214
180GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86063467
181TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85194626
182RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84514607
183PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84453747
184BCAT_22108803_ChIP-Seq_LS180_Human0.84086034
185* KDM2B_26808549_Chip-Seq_K562_Human0.81039359
186MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.80257807
187NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79357925
188GATA1_22025678_ChIP-Seq_K562_Human0.78519732
189ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.78500390
190KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.77624771
191CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77468581
192NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76751316
193NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76751316
194SMAD3_21741376_ChIP-Seq_EPCs_Human0.74502102
195CBP_20019798_ChIP-Seq_JUKART_Human0.73216160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity7.44283708
2MP0002735_abnormal_chemical_nociception6.73161694
3MP0001968_abnormal_touch/_nociception5.63833647
4MP0003693_abnormal_embryo_hatching4.33357919
5MP0004957_abnormal_blastocyst_morpholog4.11078261
6MP0003111_abnormal_nucleus_morphology3.86540707
7MP0002822_catalepsy3.71354991
8MP0002733_abnormal_thermal_nociception3.45736649
9MP0002734_abnormal_mechanical_nocicepti3.39578552
10MP0006276_abnormal_autonomic_nervous3.36025055
11MP0004270_analgesia3.28810361
12MP0008932_abnormal_embryonic_tissue3.23098084
13MP0008872_abnormal_physiological_respon3.08676864
14MP0010094_abnormal_chromosome_stability3.06493511
15MP0003077_abnormal_cell_cycle2.97859372
16MP0002877_abnormal_melanocyte_morpholog2.97789388
17MP0001970_abnormal_pain_threshold2.79543063
18MP0000678_abnormal_parathyroid_gland2.62835684
19MP0005623_abnormal_meninges_morphology2.62144462
20MP0004859_abnormal_synaptic_plasticity2.60685607
21MP0001440_abnormal_grooming_behavior2.60545678
22MP0008058_abnormal_DNA_repair2.53699513
23MP0002751_abnormal_autonomic_nervous2.53399960
24MP0001730_embryonic_growth_arrest2.43371921
25MP0003941_abnormal_skin_development2.42744436
26MP0008007_abnormal_cellular_replicative2.34152516
27* MP0004858_abnormal_nervous_system2.31274788
28MP0003880_abnormal_central_pattern2.30881309
29* MP0009745_abnormal_behavioral_response2.29998276
30MP0010030_abnormal_orbit_morphology2.28508603
31MP0001188_hyperpigmentation2.27940345
32MP0002796_impaired_skin_barrier2.22473145
33MP0000537_abnormal_urethra_morphology2.16350582
34* MP0003635_abnormal_synaptic_transmissio2.09158174
35MP0003329_amyloid_beta_deposits2.08825680
36MP0004924_abnormal_behavior2.07167953
37MP0005386_behavior/neurological_phenoty2.07167953
38MP0002572_abnormal_emotion/affect_behav2.03684232
39MP0010307_abnormal_tumor_latency1.99751140
40MP0008775_abnormal_heart_ventricle1.95716191
41MP0000350_abnormal_cell_proliferation1.95090885
42MP0000427_abnormal_hair_cycle1.93631195
43MP0010386_abnormal_urinary_bladder1.91569725
44MP0004185_abnormal_adipocyte_glucose1.86489398
45MP0002249_abnormal_larynx_morphology1.86257183
46MP0002272_abnormal_nervous_system1.86037142
47MP0005501_abnormal_skin_physiology1.84426522
48MP0003123_paternal_imprinting1.83719726
49MP0008057_abnormal_DNA_replication1.83673022
50MP0000049_abnormal_middle_ear1.81867002
51MP0009672_abnormal_birth_weight1.80696612
52MP0005380_embryogenesis_phenotype1.78983570
53MP0001672_abnormal_embryogenesis/_devel1.78983570
54MP0002184_abnormal_innervation1.78474104
55MP0003806_abnormal_nucleotide_metabolis1.78266982
56MP0002638_abnormal_pupillary_reflex1.77776455
57MP0002063_abnormal_learning/memory/cond1.75216129
58MP0001529_abnormal_vocalization1.75036937
59MP0000751_myopathy1.73886339
60MP0004484_altered_response_of1.68494513
61MP0000538_abnormal_urinary_bladder1.68208403
62MP0004233_abnormal_muscle_weight1.68002691
63MP0001346_abnormal_lacrimal_gland1.67992460
64MP0003186_abnormal_redox_activity1.65578470
65MP0002254_reproductive_system_inflammat1.63018737
66MP0009053_abnormal_anal_canal1.61784336
67* MP0002064_seizures1.61154132
68MP0003786_premature_aging1.59741086
69MP0003937_abnormal_limbs/digits/tail_de1.58082096
70MP0001697_abnormal_embryo_size1.53415803
71MP0002085_abnormal_embryonic_tissue1.51617841
72MP0003718_maternal_effect1.51152697
73MP0003122_maternal_imprinting1.50776942
74MP0003315_abnormal_perineum_morphology1.50210752
75MP0002697_abnormal_eye_size1.49872929
76MP0002067_abnormal_sensory_capabilities1.49272777
77MP0003567_abnormal_fetal_cardiomyocyte1.45818489
78MP0003984_embryonic_growth_retardation1.45787739
79MP0004145_abnormal_muscle_electrophysio1.45714218
80MP0000647_abnormal_sebaceous_gland1.45612238
81MP0002080_prenatal_lethality1.43917536
82MP0002234_abnormal_pharynx_morphology1.42013272
83MP0002088_abnormal_embryonic_growth/wei1.39568135
84MP0002111_abnormal_tail_morphology1.36951073
85MP0009046_muscle_twitch1.36439345
86MP0006035_abnormal_mitochondrial_morpho1.33449043
87MP0003705_abnormal_hypodermis_morpholog1.33161215
88MP0003890_abnormal_embryonic-extraembry1.32770316
89MP0001905_abnormal_dopamine_level1.32562765
90MP0000313_abnormal_cell_death1.32535379
91MP0001756_abnormal_urination1.28829530
92MP0006036_abnormal_mitochondrial_physio1.28167038
93MP0005187_abnormal_penis_morphology1.26285067
94MP0000604_amyloidosis1.25693206
95MP0003119_abnormal_digestive_system1.24853149
96MP0002084_abnormal_developmental_patter1.24414176
97MP0005076_abnormal_cell_differentiation1.23222487
98MP0005448_abnormal_energy_balance1.22196395
99MP0000778_abnormal_nervous_system1.20821579
100MP0003453_abnormal_keratinocyte_physiol1.16959182
101MP0005165_increased_susceptibility_to1.16568494
102MP0001486_abnormal_startle_reflex1.13870432
103MP0001501_abnormal_sleep_pattern1.12214569
104MP0005423_abnormal_somatic_nervous1.11836024
105MP0004133_heterotaxia1.10384141
106MP0002098_abnormal_vibrissa_morphology1.09595622
107MP0001661_extended_life_span1.09447602
108MP0005083_abnormal_biliary_tract1.09324782
109MP0002837_dystrophic_cardiac_calcinosis1.08852906
110MP0000747_muscle_weakness1.07066788
111MP0009250_abnormal_appendicular_skeleto1.06677880
112MP0003942_abnormal_urinary_system1.06419141
113MP0002736_abnormal_nociception_after1.06133216
114MP0000579_abnormal_nail_morphology1.06090248
115MP0002086_abnormal_extraembryonic_tissu1.05716882
116MP0009333_abnormal_splenocyte_physiolog1.04854050
117MP0000749_muscle_degeneration1.03477907
118MP0002160_abnormal_reproductive_system1.03340706
119MP0010234_abnormal_vibrissa_follicle1.02953052
120MP0003656_abnormal_erythrocyte_physiolo1.00264496
121* MP0004811_abnormal_neuron_physiology0.97828911
122MP0009697_abnormal_copulation0.97127173
123MP0000428_abnormal_craniofacial_morphol0.96684339
124MP0006292_abnormal_olfactory_placode0.96683764
125MP0002882_abnormal_neuron_morphology0.95650676
126MP0004142_abnormal_muscle_tone0.94134996
127MP0000372_irregular_coat_pigmentation0.90530777
128MP0010352_gastrointestinal_tract_polyps0.89249799
129MP0000516_abnormal_urinary_system0.89218243
130MP0005367_renal/urinary_system_phenotyp0.89218243
131MP0005670_abnormal_white_adipose0.88501547
132MP0004197_abnormal_fetal_growth/weight/0.87995141
133MP0000955_abnormal_spinal_cord0.86023951
134MP0002066_abnormal_motor_capabilities/c0.85475945
135MP0002090_abnormal_vision0.84748105
136MP0005451_abnormal_body_composition0.84420623
137MP0008569_lethality_at_weaning0.82478933
138MP0000358_abnormal_cell_content/0.81490467
139MP0001849_ear_inflammation0.80723411
140MP0003959_abnormal_lean_body0.80434048
141MP0005645_abnormal_hypothalamus_physiol0.80235281
142MP0000490_abnormal_crypts_of0.80037345
143MP0004272_abnormal_basement_membrane0.79803549
144MP0002557_abnormal_social/conspecific_i0.79664533
145MP0002092_abnormal_eye_morphology0.79408201
146MP0002909_abnormal_adrenal_gland0.78628505
147MP0005535_abnormal_body_temperature0.77641823
148MP0009278_abnormal_bone_marrow0.76572629
149MP0001919_abnormal_reproductive_system0.75980956
150MP0000681_abnormal_thyroid_gland0.75257722
151MP0002069_abnormal_eating/drinking_beha0.73942047
152MP0003935_abnormal_craniofacial_develop0.73495369
153MP0003137_abnormal_impulse_conducting0.73318959
154MP0001286_abnormal_eye_development0.73227746
155MP0003632_abnormal_nervous_system0.71431021
156MP0001502_abnormal_circadian_rhythm0.71198628
157MP0003385_abnormal_body_wall0.70818566
158MP0001293_anophthalmia0.70463719
159MP0002210_abnormal_sex_determination0.69919418
160MP0003631_nervous_system_phenotype0.68190154
161MP0004808_abnormal_hematopoietic_stem0.67979055
162MP0000762_abnormal_tongue_morphology0.67643727
163MP0000733_abnormal_muscle_development0.66802424
164MP0002177_abnormal_outer_ear0.64401896
165MP0003283_abnormal_digestive_organ0.64213535
166MP0005085_abnormal_gallbladder_physiolo0.64055559
167MP0002114_abnormal_axial_skeleton0.63510613
168* MP0005379_endocrine/exocrine_gland_phen0.62740767
169MP0003633_abnormal_nervous_system0.61606689
170MP0002229_neurodegeneration0.61488851
171MP0003861_abnormal_nervous_system0.61233433
172MP0008874_decreased_physiological_sensi0.61198037
173MP0000013_abnormal_adipose_tissue0.60653364
174MP0005334_abnormal_fat_pad0.59812221
175MP0002970_abnormal_white_adipose0.58790703
176MP0009115_abnormal_fat_cell0.58227253
177MP0001727_abnormal_embryo_implantation0.58041767
178MP0009840_abnormal_foam_cell0.56066557
179MP0010771_integument_phenotype0.53929571
180MP0002752_abnormal_somatic_nervous0.53839063
181MP0003634_abnormal_glial_cell0.52588302
182MP0002876_abnormal_thyroid_physiology0.52312720
183MP0000920_abnormal_myelination0.51006937
184MP0005360_urolithiasis0.49689393
185MP0004883_abnormal_blood_vessel0.48643649
186MP0001984_abnormal_olfaction0.47671597
187MP0003879_abnormal_hair_cell0.46772186
188* MP0003953_abnormal_hormone_level0.45509797
189MP0005452_abnormal_adipose_tissue0.44299216
190MP0000759_abnormal_skeletal_muscle0.43917392
191MP0005408_hypopigmentation0.42945095
192MP0001270_distended_abdomen0.42444690
193* MP0008873_increased_physiological_sensi0.41573083
194MP0009379_abnormal_foot_pigmentation0.41284062
195MP0003638_abnormal_response/metabolism_0.40623426
196MP0002139_abnormal_hepatobiliary_system0.39359094
197MP0000639_abnormal_adrenal_gland0.39217371
198MP0009780_abnormal_chondrocyte_physiolo0.39037646

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)6.91076010
2Hypothermia (HP:0002045)6.52710504
3Myokymia (HP:0002411)6.38828443
4Hyporeflexia of lower limbs (HP:0002600)5.72280663
5Distal lower limb muscle weakness (HP:0009053)5.38376441
6Birth length less than 3rd percentile (HP:0003561)4.41599348
7Aplasia/Hypoplasia of the sacrum (HP:0008517)4.28239795
8Pheochromocytoma (HP:0002666)4.02716051
9Orthostatic hypotension (HP:0001278)4.01198262
10Abnormal umbilical cord blood vessels (HP:0011403)3.96204394
11Single umbilical artery (HP:0001195)3.96204394
12Abnormality of the fetal cardiovascular system (HP:0010948)3.96204394
13Neuroendocrine neoplasm (HP:0100634)3.86488502
14Areflexia of lower limbs (HP:0002522)3.80236309
15Short middle phalanx of the 5th finger (HP:0004220)3.71235436
16Focal seizures (HP:0007359)3.61647568
17Steppage gait (HP:0003376)3.61522253
18Abnormality of the corticospinal tract (HP:0002492)3.58598070
19Abnormal connection of the cardiac segments (HP:0011545)3.50250151
20Abnormal ventriculo-arterial connection (HP:0011563)3.50250151
21Transposition of the great arteries (HP:0001669)3.50250151
22Abnormality of pain sensation (HP:0010832)3.48322414
23Impaired pain sensation (HP:0007328)3.48322414
24Focal motor seizures (HP:0011153)3.48136509
25Foot dorsiflexor weakness (HP:0009027)3.41280092
26Selective tooth agenesis (HP:0001592)3.39448977
27Autoamputation (HP:0001218)3.38836720
28Abnormal autonomic nervous system physiology (HP:0012332)3.36021199
29Atonic seizures (HP:0010819)3.34922673
30Ankle clonus (HP:0011448)3.33521767
31Visual hallucinations (HP:0002367)3.32467963
32Termporal pattern (HP:0011008)3.30879642
33Insidious onset (HP:0003587)3.30879642
34Abnormality of the umbilical cord (HP:0010881)3.29907481
35EMG: neuropathic changes (HP:0003445)3.16738460
36Myotonia (HP:0002486)3.16673377
37Amblyopia (HP:0000646)3.14462323
38Congenital malformation of the right heart (HP:0011723)3.13052686
39Double outlet right ventricle (HP:0001719)3.13052686
40Multiple enchondromatosis (HP:0005701)3.11763933
41Absence seizures (HP:0002121)3.08894471
42Abnormality of the foot musculature (HP:0001436)3.07583242
43Broad distal phalanx of finger (HP:0009836)3.03237990
44Abnormality of aromatic amino acid family metabolism (HP:0004338)2.99958951
45Failure to thrive in infancy (HP:0001531)2.96655486
46Microvesicular hepatic steatosis (HP:0001414)2.94660554
47Progressive muscle weakness (HP:0003323)2.93553485
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.89801320
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.89801320
50Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.87575321
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.86299428
52Decreased activity of mitochondrial respiratory chain (HP:0008972)2.86299428
53Abnormal hemoglobin (HP:0011902)2.82854660
54Septate vagina (HP:0001153)2.81591724
55Exotropia (HP:0000577)2.78415998
56Distal sensory impairment (HP:0002936)2.78139207
57Microretrognathia (HP:0000308)2.76761366
58Breast hypoplasia (HP:0003187)2.75733164
59Hypoplastic left heart (HP:0004383)2.73519522
60Hypoventilation (HP:0002791)2.70926720
61Truncus arteriosus (HP:0001660)2.69262596
62Progressive cerebellar ataxia (HP:0002073)2.68642418
63Spastic gait (HP:0002064)2.67855042
64Absent radius (HP:0003974)2.63826132
65Generalized tonic-clonic seizures (HP:0002069)2.63579672
66Dialeptic seizures (HP:0011146)2.61396324
67Abnormality of the distal phalanges of the toes (HP:0010182)2.60673434
68Urinary urgency (HP:0000012)2.58588721
69Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.53482625
70Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.52012575
71Rapidly progressive (HP:0003678)2.51954704
72Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.49992301
73Supranuclear gaze palsy (HP:0000605)2.49499327
74Action tremor (HP:0002345)2.48805428
75Aplasia involving forearm bones (HP:0009822)2.45802696
76Absent forearm bone (HP:0003953)2.45802696
77Reticulocytopenia (HP:0001896)2.44767286
78Wrist flexion contracture (HP:0001239)2.43542532
79Impaired vibration sensation in the lower limbs (HP:0002166)2.42498841
80Neoplasm of the peripheral nervous system (HP:0100007)2.42175259
81Hypercortisolism (HP:0001578)2.41962702
82Abnormal number of erythroid precursors (HP:0012131)2.39455276
83Axonal loss (HP:0003447)2.38936804
84Polyphagia (HP:0002591)2.38850940
85Abnormal number of incisors (HP:0011064)2.38530050
86Limb dystonia (HP:0002451)2.37567188
87Febrile seizures (HP:0002373)2.37499915
88Esophageal atresia (HP:0002032)2.37400295
89Aplastic anemia (HP:0001915)2.34908410
90Decreased motor nerve conduction velocity (HP:0003431)2.34270749
91Increased CSF lactate (HP:0002490)2.33326471
92Spastic diplegia (HP:0001264)2.33277489
93Psychosis (HP:0000709)2.33275233
94Abnormality of cells of the erythroid lineage (HP:0012130)2.32394383
95Neonatal hypoglycemia (HP:0001998)2.32348097
96Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.30665144
97Abnormality of the phalanges of the hallux (HP:0010057)2.29518039
98Anxiety (HP:0000739)2.28841026
99Mitochondrial inheritance (HP:0001427)2.28086399
100Cerebral edema (HP:0002181)2.27618155
101Agitation (HP:0000713)2.27553046
102Infantile muscular hypotonia (HP:0008947)2.25559987
103Abnormalities of placenta or umbilical cord (HP:0001194)2.25106076
104Neurofibrillary tangles (HP:0002185)2.24581536
105Oligomenorrhea (HP:0000876)2.24341254
106Abnormality of glycolysis (HP:0004366)2.24014693
107Morphological abnormality of the pyramidal tract (HP:0002062)2.22196999
108Increased serum pyruvate (HP:0003542)2.21702344
109Macrocytic anemia (HP:0001972)2.20616223
110Neonatal onset (HP:0003623)2.20383883
111Trismus (HP:0000211)2.20219758
112Abnormality of the middle phalanges of the toes (HP:0010183)2.18738500
113Increased variability in muscle fiber diameter (HP:0003557)2.17449827
114Urinary bladder sphincter dysfunction (HP:0002839)2.17058045
115Sensorimotor neuropathy (HP:0007141)2.13937154
116Nonimmune hydrops fetalis (HP:0001790)2.12754173
117Unilateral renal agenesis (HP:0000122)2.12443748
118Hyperthyroidism (HP:0000836)2.11191223
119Ragged-red muscle fibers (HP:0003200)2.10920411
120Epileptic encephalopathy (HP:0200134)2.09633877
121Hammertoe (HP:0001765)2.07929674
122Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.07419152
123Sparse eyelashes (HP:0000653)2.06731368
124Acute necrotizing encephalopathy (HP:0006965)2.06654195
125Diaphragmatic weakness (HP:0009113)2.06579096
126Rectal fistula (HP:0100590)2.06126519
127Rectovaginal fistula (HP:0000143)2.06126519
128Abnormality of the phalanges of the 5th finger (HP:0004213)2.05507846
129Abnormality of the vocal cords (HP:0008777)2.05035073
130Increased serum lactate (HP:0002151)2.04718530
131Vaginal fistula (HP:0004320)2.04483599
132Cerebral inclusion bodies (HP:0100314)2.04253359
133Secondary amenorrhea (HP:0000869)2.03915795
134Aplasia/Hypoplasia of the brainstem (HP:0007362)2.02789341
135Hypoplasia of the brainstem (HP:0002365)2.02789341
136Horseshoe kidney (HP:0000085)2.01893275
137Lower limb muscle weakness (HP:0007340)2.01820953
138Hypoplastic heart (HP:0001961)2.01449717
139Bradycardia (HP:0001662)2.01132789
140Degeneration of anterior horn cells (HP:0002398)2.00353667
141Abnormality of the anterior horn cell (HP:0006802)2.00353667
142Slow progression (HP:0003677)2.00060904
143Cerebral hemorrhage (HP:0001342)1.99779353
144Poor suck (HP:0002033)1.99548678
145Acute encephalopathy (HP:0006846)1.98844314
146Anosmia (HP:0000458)1.96420616
147Testicular atrophy (HP:0000029)1.95917406
148Rough bone trabeculation (HP:0100670)1.95306822
149Lactic acidosis (HP:0003128)1.94972075
150Dysphonia (HP:0001618)1.94658997
151Hepatocellular necrosis (HP:0001404)1.94461695
152Depression (HP:0000716)1.88573792
153Nasal speech (HP:0001611)1.88357783
154Papilledema (HP:0001085)1.88311798
155EEG with generalized epileptiform discharges (HP:0011198)1.87812253
156Progressive macrocephaly (HP:0004481)1.86601951
157Short 5th finger (HP:0009237)1.86081337
158Sensory axonal neuropathy (HP:0003390)1.86019343
159Ulnar bowing (HP:0003031)1.85766343
160Delayed gross motor development (HP:0002194)1.84765914
161Cleft eyelid (HP:0000625)1.83612362
162Abnormal eating behavior (HP:0100738)1.82914361
163Premature ovarian failure (HP:0008209)1.82688309
164Palpitations (HP:0001962)1.82050226
165Abnormality of calcium-phosphate metabolism (HP:0100530)1.81494556
166Type I transferrin isoform profile (HP:0003642)1.81437086
167Hypotension (HP:0002615)1.81261426
168Epileptiform EEG discharges (HP:0011182)1.80363545
169Hypsarrhythmia (HP:0002521)1.80293461
170Clonus (HP:0002169)1.80031042
171Pes cavus (HP:0001761)1.79510385
172Gout (HP:0001997)1.79021977
173Abnormal mitochondria in muscle tissue (HP:0008316)1.78657693
174Increased hepatocellular lipid droplets (HP:0006565)1.78188803
175Potter facies (HP:0002009)1.76583422
176Intestinal fistula (HP:0100819)1.76484694
177Atresia of the external auditory canal (HP:0000413)1.75588239
178Short clavicles (HP:0000894)1.74120371
179Proximal placement of thumb (HP:0009623)1.73926786
180Chromosomal breakage induced by crosslinking agents (HP:0003221)1.73261782
181Squamous cell carcinoma (HP:0002860)1.72980963
182Overriding aorta (HP:0002623)1.72603349
183Triphalangeal thumb (HP:0001199)1.70956766
184Abnormality of alanine metabolism (HP:0010916)1.69848825
185Hyperalaninemia (HP:0003348)1.69848825
186Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69848825
187Exercise intolerance (HP:0003546)1.69451175
188Anal atresia (HP:0002023)1.69090611
1893-Methylglutaconic aciduria (HP:0003535)1.69044370
190Brittle hair (HP:0002299)1.68641837
191Renal agenesis (HP:0000104)1.68568108
192Facial cleft (HP:0002006)1.68482088
193Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.67188274
194Respiratory failure (HP:0002878)1.66846126
195Abnormality of abdominal situs (HP:0011620)1.66185184
196Abdominal situs inversus (HP:0003363)1.66185184

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK36.96644384
2NME26.22363061
3BUB14.88615153
4CAMKK24.01515761
5NTRK13.27784133
6NTRK33.12154533
7GRK73.11888450
8CAMK1D2.97190976
9RPS6KB22.91837362
10CDC72.80231876
11VRK22.77547908
12PBK2.72273903
13SRPK12.69793352
14SMG12.58038996
15TTK2.43464167
16CAMK1G2.35477076
17STK162.25481312
18PLK42.12901866
19MAP3K102.09741274
20MAP3K41.98160960
21MAP3K91.97756511
22MATK1.93813891
23KDR1.93136688
24MINK11.89397554
25PIM21.86201425
26PDK21.83797953
27LIMK11.72890328
28EEF2K1.72013493
29EIF2AK11.70992465
30EPHA31.70018961
31FER1.68917948
32IRAK31.68075910
33PRKCE1.67059098
34ARAF1.66412585
35UHMK11.65236517
36CAMKK11.65046700
37PAK41.60221839
38MAP2K71.55354999
39TAOK21.52773695
40CHEK21.51360349
41CDK121.49701874
42LATS21.47252084
43CASK1.46136148
44KSR21.45266053
45ADRBK11.44477467
46GRK51.42058561
47MKNK11.39940644
48MAP2K41.38202236
49MAP3K81.34886036
50STK41.33619893
51MKNK21.33432584
52TNIK1.33361582
53MAP3K121.31370826
54MAP2K11.27619797
55MARK11.24679384
56PLK11.23356297
57WEE11.20316445
58CDK71.20181661
59BRSK11.17879490
60PLK31.13876122
61MAP3K21.13570764
62NTRK21.13259827
63PAK31.11953457
64BRAF1.09765758
65RET1.08347737
66TESK21.07200764
67TSSK61.07005313
68CSNK1G31.06138786
69TAF11.04928337
70DYRK31.03343223
71AURKA1.02493026
72ATR1.01561656
73BMPR1B1.00998766
74ADRBK21.00219742
75PHKG10.99008312
76PHKG20.99008312
77PNCK0.98606008
78PAK60.97971987
79MAPKAPK50.97762285
80SCYL20.97601635
81CDK50.94902584
82CSNK1G20.93231164
83EPHB10.92620309
84CDK40.90874570
85ILK0.89394249
86AURKB0.88940212
87CHEK10.88808237
88DAPK20.87639786
89DMPK0.86255564
90DYRK20.84220167
91PRPF4B0.83160032
92ZAK0.82845946
93ABL20.80355493
94MAPK130.79661219
95BCKDK0.79474097
96MUSK0.77339222
97CAMK2G0.76384889
98CDK140.76332289
99CAMK2D0.74813057
100LMTK20.72682084
101BRSK20.70046153
102ICK0.69907352
103RPS6KA40.69780219
104FGFR40.68698328
105MAPK150.67159289
106ERBB40.66938864
107CAMK2B0.66909672
108CSNK2A10.66109088
109DAPK30.65622703
110PAK10.65175550
111MAPK40.63677181
112ALK0.63249043
113AKT20.63198750
114SGK2230.62466992
115SGK4940.62466992
116VRK10.61565578
117CAMK2A0.61121973
118DAPK10.58848995
119RPS6KA20.58125144
120CDK20.57125484
121TAOK10.57068921
122STK390.57060943
123PRKG20.56608906
124CSNK2A20.55874815
125CDK180.54176344
126PRKCG0.53850156
127NME10.53770119
128PRKCB0.53278145
129PRKD10.53061857
130BCR0.52818818
131STK100.52302119
132CDK150.52000696
133CDK10.50335584
134RPS6KA50.50251860
135ATM0.50202175
136MST40.48817841
137CSNK1G10.48050723
138CSNK1E0.48028742
139CLK10.48007007
140MAP2K30.47846949
141PIM10.47779896
142CSNK1A1L0.47663388
143PTK2B0.47470312
144MTOR0.47264466
145PRKACA0.44980351
146CDK80.43718933
147CDK11A0.41677361
148TRIB30.41468140
149SRC0.40112987
150NEK20.39103173
151MAP3K10.38600559
152CAMK40.38207007
153BMX0.38066181
154TESK10.37997899
155LRRK20.36468210
156CDK90.36122004
157NEK10.36060865
158RIPK40.35389535
159PRKACG0.35209591
160IRAK20.34276683
161EIF2AK20.33985083
162OXSR10.33813461
163WNK10.32770169
164ERBB20.32478388
165CAMK10.31979942
166BRD40.31951110
167CDK190.29112020
168WNK40.28937211
169EPHA40.28159322
170FYN0.27811500
171TYRO30.27526993
172FES0.25970227
173PRKCA0.25420332
174PTK20.25284898
175MYLK0.24652738

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.14938659
2Ribosome_Homo sapiens_hsa030104.06223635
3Synaptic vesicle cycle_Homo sapiens_hsa047213.56843134
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19169719
5Mismatch repair_Homo sapiens_hsa034302.99630172
6Spliceosome_Homo sapiens_hsa030402.92453814
7Sulfur relay system_Homo sapiens_hsa041222.76980144
8RNA polymerase_Homo sapiens_hsa030202.74051971
9Base excision repair_Homo sapiens_hsa034102.63778198
10Oxidative phosphorylation_Homo sapiens_hsa001902.60005835
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38830617
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.38399965
13One carbon pool by folate_Homo sapiens_hsa006702.32825042
14Pyrimidine metabolism_Homo sapiens_hsa002402.29530702
15Collecting duct acid secretion_Homo sapiens_hsa049662.25605558
16RNA transport_Homo sapiens_hsa030132.23909012
17Nicotine addiction_Homo sapiens_hsa050332.21520138
18Parkinsons disease_Homo sapiens_hsa050122.09412154
19Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.04250487
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00946534
21Cysteine and methionine metabolism_Homo sapiens_hsa002702.00471336
22Taste transduction_Homo sapiens_hsa047421.96479553
23Cell cycle_Homo sapiens_hsa041101.92489859
24Homologous recombination_Homo sapiens_hsa034401.86728375
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81688449
26Vibrio cholerae infection_Homo sapiens_hsa051101.81168031
27Dopaminergic synapse_Homo sapiens_hsa047281.81007411
28GABAergic synapse_Homo sapiens_hsa047271.78232881
29Vitamin B6 metabolism_Homo sapiens_hsa007501.76005234
30Phenylalanine metabolism_Homo sapiens_hsa003601.75264621
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74461493
32Biosynthesis of amino acids_Homo sapiens_hsa012301.72333258
33Amphetamine addiction_Homo sapiens_hsa050311.70866494
34Cocaine addiction_Homo sapiens_hsa050301.70372624
35Cardiac muscle contraction_Homo sapiens_hsa042601.67177068
36Tyrosine metabolism_Homo sapiens_hsa003501.66906210
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.66463146
38Nucleotide excision repair_Homo sapiens_hsa034201.59450109
39Alzheimers disease_Homo sapiens_hsa050101.57404606
40Cholinergic synapse_Homo sapiens_hsa047251.53741729
41Serotonergic synapse_Homo sapiens_hsa047261.53524674
42Steroid biosynthesis_Homo sapiens_hsa001001.51702703
43Olfactory transduction_Homo sapiens_hsa047401.45145392
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40863489
45Proteasome_Homo sapiens_hsa030501.38201367
46Circadian entrainment_Homo sapiens_hsa047131.37001033
47Gap junction_Homo sapiens_hsa045401.36040435
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35728518
49Insulin secretion_Homo sapiens_hsa049111.34397713
50Morphine addiction_Homo sapiens_hsa050321.27080897
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26612924
52Huntingtons disease_Homo sapiens_hsa050161.25545609
53Purine metabolism_Homo sapiens_hsa002301.20416990
54Phagosome_Homo sapiens_hsa041451.18570903
55Glutamatergic synapse_Homo sapiens_hsa047241.17812452
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17111305
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16442622
58mRNA surveillance pathway_Homo sapiens_hsa030151.16095071
59Non-homologous end-joining_Homo sapiens_hsa034501.13922180
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13146704
61Renin secretion_Homo sapiens_hsa049241.12787039
62Long-term potentiation_Homo sapiens_hsa047201.11641600
63Basal transcription factors_Homo sapiens_hsa030221.11212150
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11004604
65Selenocompound metabolism_Homo sapiens_hsa004501.09088650
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07601192
67Pancreatic secretion_Homo sapiens_hsa049721.07569675
68Fanconi anemia pathway_Homo sapiens_hsa034601.07298367
69RNA degradation_Homo sapiens_hsa030181.05954764
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04771635
71Histidine metabolism_Homo sapiens_hsa003401.02579748
72Pentose phosphate pathway_Homo sapiens_hsa000301.00907315
73Oxytocin signaling pathway_Homo sapiens_hsa049211.00585150
74Fatty acid elongation_Homo sapiens_hsa000621.00416870
75Galactose metabolism_Homo sapiens_hsa000520.99942566
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.99106896
77Bladder cancer_Homo sapiens_hsa052190.98696588
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97737643
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97593965
80Glutathione metabolism_Homo sapiens_hsa004800.94284150
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91944178
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91743213
83Long-term depression_Homo sapiens_hsa047300.89343546
84Butanoate metabolism_Homo sapiens_hsa006500.89199768
85Gastric acid secretion_Homo sapiens_hsa049710.88979517
86VEGF signaling pathway_Homo sapiens_hsa043700.88688264
87GnRH signaling pathway_Homo sapiens_hsa049120.86020615
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83916401
89Tryptophan metabolism_Homo sapiens_hsa003800.83634603
90Calcium signaling pathway_Homo sapiens_hsa040200.83519813
91Type II diabetes mellitus_Homo sapiens_hsa049300.82704357
92Bile secretion_Homo sapiens_hsa049760.81925655
93Thyroid cancer_Homo sapiens_hsa052160.81140583
94Sulfur metabolism_Homo sapiens_hsa009200.80690132
95Prion diseases_Homo sapiens_hsa050200.80249211
96p53 signaling pathway_Homo sapiens_hsa041150.79910553
97Dilated cardiomyopathy_Homo sapiens_hsa054140.76518100
98Salivary secretion_Homo sapiens_hsa049700.76329621
99Pyruvate metabolism_Homo sapiens_hsa006200.71939629
100Estrogen signaling pathway_Homo sapiens_hsa049150.71134438
101Protein export_Homo sapiens_hsa030600.66924690
102Fructose and mannose metabolism_Homo sapiens_hsa000510.66865971
103Axon guidance_Homo sapiens_hsa043600.65842653
104Metabolic pathways_Homo sapiens_hsa011000.65557988
105ErbB signaling pathway_Homo sapiens_hsa040120.65429168
106Rheumatoid arthritis_Homo sapiens_hsa053230.64629128
107Basal cell carcinoma_Homo sapiens_hsa052170.64616645
108Glycerolipid metabolism_Homo sapiens_hsa005610.62717362
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60719906
110Glioma_Homo sapiens_hsa052140.60421802
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59909457
112Insulin signaling pathway_Homo sapiens_hsa049100.59251066
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.57692256
114Arginine biosynthesis_Homo sapiens_hsa002200.57647597
115Propanoate metabolism_Homo sapiens_hsa006400.57262446
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56394006
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55260439
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54547216
119Folate biosynthesis_Homo sapiens_hsa007900.54266375
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53661442
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52809083
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52355034
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51698344
124N-Glycan biosynthesis_Homo sapiens_hsa005100.51078009
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47919246
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47702405
127Epstein-Barr virus infection_Homo sapiens_hsa051690.47563191
128Arginine and proline metabolism_Homo sapiens_hsa003300.46646099
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.46504686
130Fatty acid metabolism_Homo sapiens_hsa012120.45375620
131Wnt signaling pathway_Homo sapiens_hsa043100.44690830
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43220967
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41802307
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.41651832
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.41020744
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40945676
137Oocyte meiosis_Homo sapiens_hsa041140.40222278
1382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39805329
139Drug metabolism - other enzymes_Homo sapiens_hsa009830.38911459
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.38000816
141Fat digestion and absorption_Homo sapiens_hsa049750.36429691
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.36057811
143Alcoholism_Homo sapiens_hsa050340.35836127
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35822437
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.35457917
146Vitamin digestion and absorption_Homo sapiens_hsa049770.35345978
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34676372
148Melanogenesis_Homo sapiens_hsa049160.34503134
149Hippo signaling pathway_Homo sapiens_hsa043900.34429128
150MAPK signaling pathway_Homo sapiens_hsa040100.32739576
151Adipocytokine signaling pathway_Homo sapiens_hsa049200.32516103
152Thyroid hormone synthesis_Homo sapiens_hsa049180.32016958
153Glucagon signaling pathway_Homo sapiens_hsa049220.31684685
154Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30964101
155Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30765386
156Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29631027
157Notch signaling pathway_Homo sapiens_hsa043300.29540294
158Carbon metabolism_Homo sapiens_hsa012000.29100795
159Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29051651
160Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28580395
161TGF-beta signaling pathway_Homo sapiens_hsa043500.28234797
162HTLV-I infection_Homo sapiens_hsa051660.25295456
163Melanoma_Homo sapiens_hsa052180.24937426
164Hedgehog signaling pathway_Homo sapiens_hsa043400.23062849
165Lysosome_Homo sapiens_hsa041420.22763855
166MicroRNAs in cancer_Homo sapiens_hsa052060.21651969
167Lysine degradation_Homo sapiens_hsa003100.20136110
168Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13162816
169Adherens junction_Homo sapiens_hsa045200.11929689
170Viral carcinogenesis_Homo sapiens_hsa052030.11739934
171Apoptosis_Homo sapiens_hsa042100.10503251
172Colorectal cancer_Homo sapiens_hsa052100.10025254

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