GAL3ST2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. This enzyme has been implicated in tumor metastasis processes. This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingosine metabolic process (GO:0006670)7.87544321
2diol metabolic process (GO:0034311)7.27598496
3regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.90670519
4phenylpropanoid metabolic process (GO:0009698)6.81908687
5detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)6.52329227
6sphingoid metabolic process (GO:0046519)6.13933979
7virion attachment to host cell (GO:0019062)6.05904244
8adhesion of symbiont to host cell (GO:0044650)6.05904244
9vitamin A metabolic process (GO:0006776)5.85152839
10actin filament depolymerization (GO:0030042)5.71342773
11regulation of bile acid biosynthetic process (GO:0070857)5.42279432
12drug catabolic process (GO:0042737)5.30480820
13hormone catabolic process (GO:0042447)5.20642215
14digestive system process (GO:0022600)5.19962440
15flavonoid metabolic process (GO:0009812)5.15171388
16purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.11416914
173-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.11416914
18UDP-N-acetylglucosamine metabolic process (GO:0006047)5.08690499
19phospholipid efflux (GO:0033700)4.92009488
20adhesion of symbiont to host (GO:0044406)4.84861516
21regulation of cholesterol esterification (GO:0010872)4.76096090
22modified amino acid transport (GO:0072337)4.73646323
23plasma lipoprotein particle assembly (GO:0034377)4.68250878
24regulation of lipoprotein metabolic process (GO:0050746)4.65194666
25triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.51501331
26protein-chromophore linkage (GO:0018298)4.49133308
27protein-lipid complex assembly (GO:0065005)4.45881274
28peptide catabolic process (GO:0043171)4.39268304
29lipoprotein metabolic process (GO:0042157)4.37869978
30positive regulation of triglyceride lipase activity (GO:0061365)4.37807352
31positive regulation of lipoprotein lipase activity (GO:0051006)4.37807352
32xenobiotic catabolic process (GO:0042178)4.36693871
33bundle of His cell to Purkinje myocyte communication (GO:0086069)4.34595970
34cholesterol efflux (GO:0033344)4.32475573
35sperm capacitation (GO:0048240)4.31628303
36epithelial structure maintenance (GO:0010669)4.30690299
37cellular glucuronidation (GO:0052695)4.30203773
38regulation of triglyceride catabolic process (GO:0010896)4.25362365
39regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.19315028
40glucuronate metabolic process (GO:0019585)4.11796253
41uronic acid metabolic process (GO:0006063)4.11796253
42sulfate transmembrane transport (GO:1902358)4.10583587
43lipopolysaccharide biosynthetic process (GO:0009103)4.10060996
44peptide hormone processing (GO:0016486)4.08891309
45digestion (GO:0007586)4.07193280
46very-low-density lipoprotein particle assembly (GO:0034379)4.04399596
47glycosphingolipid catabolic process (GO:0046479)4.04001740
48glucose 6-phosphate metabolic process (GO:0051156)3.91102996
49regulation of ARF GTPase activity (GO:0032312)3.90802825
50negative regulation of glycoprotein biosynthetic process (GO:0010561)3.89931845
51lipoprotein transport (GO:0042953)3.86932741
52vitamin transmembrane transport (GO:0035461)3.86305265
53proline metabolic process (GO:0006560)3.78236982
54detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.78188920
55cholesterol homeostasis (GO:0042632)3.75756904
56calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.74905553
57striated muscle atrophy (GO:0014891)3.74495028
58cellular response to hepatocyte growth factor stimulus (GO:0035729)3.72656856
59response to hepatocyte growth factor (GO:0035728)3.72656856
60sterol homeostasis (GO:0055092)3.72038029
61positive regulation of p38MAPK cascade (GO:1900745)3.69440963
62L-phenylalanine metabolic process (GO:0006558)3.63753116
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.63753116
64response to hydroperoxide (GO:0033194)3.62323011
65cholesterol transport (GO:0030301)3.61629648
66sterol transport (GO:0015918)3.61629648
67DNA methylation involved in gamete generation (GO:0043046)3.61082316
68protein retention in ER lumen (GO:0006621)3.60607062
69oligosaccharide catabolic process (GO:0009313)3.60059725
70lipopolysaccharide metabolic process (GO:0008653)3.58753585
71drinking behavior (GO:0042756)3.58038339
72glycolipid catabolic process (GO:0019377)3.56110589
73embryonic process involved in female pregnancy (GO:0060136)3.55626576
74alkaloid metabolic process (GO:0009820)3.51836837
75transepithelial transport (GO:0070633)3.48543184
76negative regulation of cholesterol transport (GO:0032375)3.46575677
77negative regulation of sterol transport (GO:0032372)3.46575677
78response to vitamin A (GO:0033189)3.46493490
79diacylglycerol metabolic process (GO:0046339)3.46358862
80hepatocyte apoptotic process (GO:0097284)3.46186562
81L-phenylalanine catabolic process (GO:0006559)3.42724288
82erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.42724288
83bile acid and bile salt transport (GO:0015721)3.42126891
84bicarbonate transport (GO:0015701)3.41230181
85hydrogen peroxide catabolic process (GO:0042744)3.41039559
86sulfur compound transport (GO:0072348)3.39970182
87maintenance of gastrointestinal epithelium (GO:0030277)3.39786849
88intestinal epithelial cell development (GO:0060576)3.38613524
89maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.36162231
90proline biosynthetic process (GO:0006561)3.32653791
91detection of chemical stimulus involved in sensory perception (GO:0050907)3.31111384
92receptor catabolic process (GO:0032801)3.30664323
93sulfate transport (GO:0008272)3.30123057
94regulation of cholesterol transport (GO:0032374)3.29037439
95regulation of sterol transport (GO:0032371)3.29037439
96negative regulation of sodium ion transport (GO:0010766)3.28649349
97skeletal muscle adaptation (GO:0043501)3.26164863
98regulation of cholesterol homeostasis (GO:2000188)3.26004112
99desmosome organization (GO:0002934)3.25723201
100reverse cholesterol transport (GO:0043691)3.22643868
101exogenous drug catabolic process (GO:0042738)3.19895389
102O-glycan processing (GO:0016266)3.18535003
103regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.17209680
104endocrine process (GO:0050886)3.17209680
105regulation of systemic arterial blood pressure by hormone (GO:0001990)3.17209680
106regulation of interleukin-5 production (GO:0032674)3.14347238
107positive regulation of fatty acid oxidation (GO:0046321)3.14250940
108regulation of G0 to G1 transition (GO:0070316)3.14094451
109epoxygenase P450 pathway (GO:0019373)3.14010072
110phosphate ion homeostasis (GO:0055062)3.10776111
111trivalent inorganic anion homeostasis (GO:0072506)3.10776111
112glomerular filtration (GO:0003094)3.10019578
113polyol transport (GO:0015791)3.09220857
114negative regulation of digestive system process (GO:0060457)3.09081729
115germinal center formation (GO:0002467)3.08013333
116positive regulation of fatty acid biosynthetic process (GO:0045723)3.03933126
117muscle atrophy (GO:0014889)3.03592498
118cellular carbohydrate catabolic process (GO:0044275)3.02482090
119regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.02155455
120receptor recycling (GO:0001881)3.01495744
121ceramide catabolic process (GO:0046514)3.01469120
122glucocorticoid biosynthetic process (GO:0006704)3.00381952
123positive regulation of fatty acid beta-oxidation (GO:0032000)2.97756553
124tight junction assembly (GO:0070830)2.96889780
125regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.96086226
126protein kinase C signaling (GO:0070528)2.94374187
127renal filtration (GO:0097205)2.92986644
128high-density lipoprotein particle remodeling (GO:0034375)2.92362745
129sphingomyelin metabolic process (GO:0006684)2.91922299
130cellular response to epidermal growth factor stimulus (GO:0071364)2.91539901
131negative regulation of myotube differentiation (GO:0010832)2.91074614
132phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.90350865
133nucleobase catabolic process (GO:0046113)2.85002478
134negative regulation of glycoprotein metabolic process (GO:1903019)2.84571959
135cellular response to pH (GO:0071467)2.84521735
136protein O-linked glycosylation (GO:0006493)2.83323935
137glomerulus development (GO:0032835)2.82645359
138thrombin receptor signaling pathway (GO:0070493)2.82036963
139regulation of germinal center formation (GO:0002634)2.81140704
140regulation of RIG-I signaling pathway (GO:0039535)2.80260866
141mannose metabolic process (GO:0006013)2.80072460
142transcytosis (GO:0045056)2.79948095
143thyroid hormone metabolic process (GO:0042403)2.79151424
144peptidyl-tyrosine autophosphorylation (GO:0038083)2.78342065
145regulation of vitamin metabolic process (GO:0030656)2.73803546
146regulation of fatty acid beta-oxidation (GO:0031998)2.69992409
147regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.68037383
148positive regulation of Cdc42 GTPase activity (GO:0043089)2.66700117
149positive regulation of respiratory burst (GO:0060267)2.65967052
150lung epithelium development (GO:0060428)2.64686942
151notochord development (GO:0030903)2.61371573
152ethanol metabolic process (GO:0006067)2.60853002
153sexual reproduction (GO:0019953)2.57860076
154response to epidermal growth factor (GO:0070849)2.57827052
155insulin-like growth factor receptor signaling pathway (GO:0048009)2.56648485
156Golgi transport vesicle coating (GO:0048200)2.56282245
157COPI coating of Golgi vesicle (GO:0048205)2.56282245
158excretion (GO:0007588)2.55785603
159retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.55746770
160regulation of protein glycosylation (GO:0060049)2.50230859
161phosphatidylethanolamine metabolic process (GO:0046337)2.45753802
162response to laminar fluid shear stress (GO:0034616)2.44780110
163chromosome condensation (GO:0030261)2.42937741
164histone H3-K9 demethylation (GO:0033169)2.42337257
165regulation of pigment cell differentiation (GO:0050932)2.42102461
166phosphatidylethanolamine biosynthetic process (GO:0006646)2.41967823
167retrograde transport, vesicle recycling within Golgi (GO:0000301)2.40288459
168cell-cell junction maintenance (GO:0045217)2.39849096
169activation of Rac GTPase activity (GO:0032863)2.38884303
170biotin metabolic process (GO:0006768)2.38736692
171positive regulation of lipid catabolic process (GO:0050996)2.38734229
172branching involved in mammary gland duct morphogenesis (GO:0060444)2.36057295
173response to acidic pH (GO:0010447)2.35556145
174positive regulation of extracellular matrix organization (GO:1903055)2.33137261
175regulation of integrin activation (GO:0033623)2.31287158
176low-density lipoprotein particle remodeling (GO:0034374)2.29645035
177ganglioside metabolic process (GO:0001573)2.29500310
178oligosaccharide biosynthetic process (GO:0009312)2.29108296
179regulation of extracellular matrix organization (GO:1903053)2.28753304
180response to mercury ion (GO:0046689)2.28459482
181intestinal absorption (GO:0050892)11.6449633
182intestinal cholesterol absorption (GO:0030299)11.4637898
183angiotensin maturation (GO:0002003)10.9323910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.25092497
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.68187363
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.34309985
4LXR_22292898_ChIP-Seq_THP-1_Human2.94917911
5GATA4_25053715_ChIP-Seq_YYC3_Human2.77283115
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.59454195
7GATA6_25053715_ChIP-Seq_YYC3_Human2.49480539
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.49070533
9SOX2_20726797_ChIP-Seq_SW620_Human2.46453202
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.41419462
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.36648817
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.34989191
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32143920
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.25025720
15FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.23363014
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.23084622
17PPAR_26484153_Chip-Seq_NCI-H1993_Human2.21206049
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.20962393
19ESR1_20079471_ChIP-ChIP_T-47D_Human2.04680773
20RXR_22158963_ChIP-Seq_LIVER_Mouse2.04510532
21CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.02259981
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.00991080
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.98637521
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.97263282
25TCF7_22412390_ChIP-Seq_EML_Mouse1.94872734
26SMC4_20622854_ChIP-Seq_HELA_Human1.93569074
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.88397947
28* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85520832
29P68_20966046_ChIP-Seq_HELA_Human1.81051246
30KLF5_25053715_ChIP-Seq_YYC3_Human1.80789054
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.80649850
32VDR_21846776_ChIP-Seq_THP-1_Human1.79590488
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75727207
34AR_21909140_ChIP-Seq_LNCAP_Human1.69470694
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.68671311
36* RUNX1_27514584_Chip-Seq_MCF-7_Human1.68083176
37CLOCK_20551151_ChIP-Seq_293T_Human1.64733469
38* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64700549
39MYC_22102868_ChIP-Seq_BL_Human1.63932503
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.62772763
41* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.62063612
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.61049073
43BCOR_27268052_Chip-Seq_Bcells_Human1.60903164
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58769500
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.57132314
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.56943521
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56058519
48STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.55151415
49KDM2B_26808549_Chip-Seq_K562_Human1.53168611
50AR_21572438_ChIP-Seq_LNCaP_Human1.53141876
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50255794
52FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.49706290
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47299678
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45310029
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44940109
56E2F1_20622854_ChIP-Seq_HELA_Human1.41664546
57GATA2_19941826_ChIP-Seq_K562_Human1.41261434
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.40337698
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39229772
60CTCF_27219007_Chip-Seq_Bcells_Human1.39215849
61TP63_22573176_ChIP-Seq_HFKS_Human1.38943646
62BCL6_27268052_Chip-Seq_Bcells_Human1.38920657
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38817684
64SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37529709
65* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.37454996
66* TCF4_18268006_ChIP-ChIP_LS174T_Human1.35876154
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35784384
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.35610193
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35155289
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34998087
71* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34855246
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32811561
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32795728
74* RACK7_27058665_Chip-Seq_MCF-7_Human1.32605786
75SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32405584
76PHF8_20622854_ChIP-Seq_HELA_Human1.30477119
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29586334
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29518971
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.28296465
80VDR_24763502_ChIP-Seq_THP-1_Human1.27846163
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.27734478
82KDM2B_26808549_Chip-Seq_DND41_Human1.26832469
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.25002992
84* HNF4A_19822575_ChIP-Seq_HepG2_Human1.22425135
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.22402561
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21746144
87* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21676285
88TP53_22127205_ChIP-Seq_IMR90_Human1.21658461
89NCOR1_26117541_ChIP-Seq_K562_Human1.20105628
90FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.20022470
91IRF8_22096565_ChIP-ChIP_GC-B_Human1.19716700
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.19471965
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18445883
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18370071
95CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17883461
96JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.17037511
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15684717
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15344267
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13945970
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11881999
101CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11541666
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11213204
103SMAD3_21741376_ChIP-Seq_HESCs_Human1.10870819
104JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10452827
105SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10104138
106SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10104138
107STAT1_20625510_ChIP-Seq_HELA_Human1.10025500
108STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09803128
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08897398
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08672927
111FOXA1_25552417_ChIP-Seq_VCAP_Human1.08616414
112ATF3_27146783_Chip-Seq_COLON_Human1.08364380
113VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07843829
114GATA1_22025678_ChIP-Seq_K562_Human1.07248626
115AHR_22903824_ChIP-Seq_MCF-7_Human1.04656230
116SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04175196
117TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04046416
118DROSHA_22980978_ChIP-Seq_HELA_Human1.03553667
119TP63_23658742_ChIP-Seq_EP156T_Human1.02924880
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02702657
121ZNF263_19887448_ChIP-Seq_K562_Human1.01827455
122SCL_19346495_ChIP-Seq_HPC-7_Human1.01713548
123MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01603317
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00112752
125KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98878239
126RAC3_21632823_ChIP-Seq_H3396_Human0.98665665
127OCT4_19829295_ChIP-Seq_ESCs_Human0.98257768
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98192476
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97890683
130ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97611659
131FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96315767
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96059875
133SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95720562
134JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95705978
135CREB1_26743006_Chip-Seq_LNCaP_Human0.95627521
136PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95473501
137SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94999173
138TP53_16413492_ChIP-PET_HCT116_Human0.93382200
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92546445
140P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92187592
141TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87076882
142GATA1_19941826_ChIP-Seq_K562_Human0.85164745
143VDR_24787735_ChIP-Seq_THP-1_Human0.83471908
144CDX2_22108803_ChIP-Seq_LS180_Human0.82374988
145GATA2_21666600_ChIP-Seq_HMVEC_Human0.81365331
146HIF1A_21447827_ChIP-Seq_MCF-7_Human0.81249635
147GATA1_26923725_Chip-Seq_HPCs_Mouse0.81154520
148PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.80266850
149STAT1_17558387_ChIP-Seq_HELA_Human0.79495618
150GATA3_24758297_ChIP-Seq_MCF-7_Human0.79479757
151PIAS1_25552417_ChIP-Seq_VCAP_Human0.78613379
152FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.77711314
153TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76417551
154NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76007550
155TCF3_18692474_ChIP-Seq_MESCs_Mouse0.75273688
156CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.75155054
157NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75087858
158NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75087858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.43287256
2MP0001666_abnormal_nutrient_absorption5.75657824
3MP0009840_abnormal_foam_cell3.61508406
4MP0002254_reproductive_system_inflammat3.49996628
5MP0003045_fibrosis3.44822283
6MP0010234_abnormal_vibrissa_follicle3.44558980
7MP0008875_abnormal_xenobiotic_pharmacok3.41800694
8MP0004264_abnormal_extraembryonic_tissu3.36642306
9MP0003183_abnormal_peptide_metabolism3.35330718
10MP0002837_dystrophic_cardiac_calcinosis3.32486967
11MP0003136_yellow_coat_color3.13862821
12MP0002653_abnormal_ependyma_morphology3.10881078
13MP0005085_abnormal_gallbladder_physiolo3.09117304
14MP0005670_abnormal_white_adipose3.02170757
15MP0003172_abnormal_lysosome_physiology2.93976609
16MP0002139_abnormal_hepatobiliary_system2.89356342
17MP0005076_abnormal_cell_differentiation2.73348615
18MP0003252_abnormal_bile_duct2.71539489
19MP0000462_abnormal_digestive_system2.69768748
20MP0010352_gastrointestinal_tract_polyps2.45885682
21MP0010329_abnormal_lipoprotein_level2.44711059
22MP0005171_absent_coat_pigmentation2.42047729
23MP0009780_abnormal_chondrocyte_physiolo2.41007132
24MP0005499_abnormal_olfactory_system2.39288770
25MP0005394_taste/olfaction_phenotype2.39288770
26MP0004147_increased_porphyrin_level2.31551544
27MP0005058_abnormal_lysosome_morphology2.29193700
28MP0003866_abnormal_defecation2.28737856
29MP0008789_abnormal_olfactory_epithelium2.20139998
30MP0002009_preneoplasia2.18634696
31MP0001873_stomach_inflammation2.11215431
32MP0005377_hearing/vestibular/ear_phenot2.11209553
33MP0003878_abnormal_ear_physiology2.11209553
34MP0005410_abnormal_fertilization2.11191897
35MP0005365_abnormal_bile_salt1.94545540
36MP0003300_gastrointestinal_ulcer1.87377961
37MP0005310_abnormal_salivary_gland1.71330087
38MP0010155_abnormal_intestine_physiology1.67745867
39MP0002822_catalepsy1.63864128
40MP0003890_abnormal_embryonic-extraembry1.63269119
41MP0009053_abnormal_anal_canal1.60593575
42MP0009379_abnormal_foot_pigmentation1.60554117
43MP0005381_digestive/alimentary_phenotyp1.59442941
44MP0001663_abnormal_digestive_system1.57181351
45MP0001346_abnormal_lacrimal_gland1.57150586
46MP0004019_abnormal_vitamin_homeostasis1.55479633
47MP0005084_abnormal_gallbladder_morpholo1.52103715
48MP0002168_other_aberrant_phenotype1.51755946
49MP0000678_abnormal_parathyroid_gland1.46624747
50MP0000477_abnormal_intestine_morphology1.38816320
51MP0002132_abnormal_respiratory_system1.38657068
52MP0000537_abnormal_urethra_morphology1.38016546
53MP0000566_synostosis1.32766106
54MP0004043_abnormal_pH_regulation1.28917949
55MP0002277_abnormal_respiratory_mucosa1.28467591
56MP0009384_cardiac_valve_regurgitation1.28380578
57MP0003705_abnormal_hypodermis_morpholog1.27926360
58MP0000538_abnormal_urinary_bladder1.27661636
59MP0003436_decreased_susceptibility_to1.27155360
60MP0003646_muscle_fatigue1.24184699
61MP0005666_abnormal_adipose_tissue1.18619174
62MP0002138_abnormal_hepatobiliary_system1.17739345
63MP0008004_abnormal_stomach_pH1.14734652
64MP0000490_abnormal_crypts_of1.12080101
65MP0002796_impaired_skin_barrier1.11441028
66MP0005448_abnormal_energy_balance1.08301019
67MP0002876_abnormal_thyroid_physiology1.07869642
68MP0009278_abnormal_bone_marrow1.05578519
69MP0001849_ear_inflammation1.05209025
70MP0004381_abnormal_hair_follicle1.03953236
71MP0009643_abnormal_urine_homeostasis1.03935670
72MP0005409_darkened_coat_color1.03707248
73MP0003303_peritoneal_inflammation1.02933879
74MP0005332_abnormal_amino_acid1.01677311
75MP0001664_abnormal_digestion1.00809548
76MP0004233_abnormal_muscle_weight1.00695180
77MP0002166_altered_tumor_susceptibility1.00513595
78MP0010678_abnormal_skin_adnexa0.97582836
79MP0003453_abnormal_keratinocyte_physiol0.96969325
80MP0003191_abnormal_cellular_cholesterol0.92582026
81MP0004947_skin_inflammation0.91675620
82MP0002249_abnormal_larynx_morphology0.90948553
83MP0005266_abnormal_metabolism0.89446543
84MP0000465_gastrointestinal_hemorrhage0.89178928
85MP0002118_abnormal_lipid_homeostasis0.88476014
86MP0000516_abnormal_urinary_system0.88344746
87MP0005367_renal/urinary_system_phenotyp0.88344746
88MP0005636_abnormal_mineral_homeostasis0.87124893
89MP0000609_abnormal_liver_physiology0.86986596
90MP0002098_abnormal_vibrissa_morphology0.86827294
91MP0005408_hypopigmentation0.86748515
92MP0000613_abnormal_salivary_gland0.86213779
93MP0002089_abnormal_postnatal_growth/wei0.86039925
94MP0001727_abnormal_embryo_implantation0.85721854
95MP0005083_abnormal_biliary_tract0.83558818
96MP0008872_abnormal_physiological_respon0.81559360
97MP0001984_abnormal_olfaction0.77651713
98MP0000467_abnormal_esophagus_morphology0.75322035
99MP0009697_abnormal_copulation0.74029095
100MP0003329_amyloid_beta_deposits0.73432360
101MP0002006_tumorigenesis0.73202225
102MP0002877_abnormal_melanocyte_morpholog0.71008312
103MP0002233_abnormal_nose_morphology0.68293592
104MP0001348_abnormal_lacrimal_gland0.66806796
105MP0005330_cardiomyopathy0.65376861
106MP0005451_abnormal_body_composition0.64727819
107MP0005025_abnormal_response_to0.64630625
108MP0005375_adipose_tissue_phenotype0.64412614
109MP0005387_immune_system_phenotype0.63774446
110MP0001790_abnormal_immune_system0.63774446
111MP0002075_abnormal_coat/hair_pigmentati0.62771676
112MP0005647_abnormal_sex_gland0.62068451
113MP0004270_analgesia0.61531300
114MP0002136_abnormal_kidney_physiology0.60608159
115MP0005395_other_phenotype0.60472332
116MP0002269_muscular_atrophy0.60146376
117MP0000470_abnormal_stomach_morphology0.59765285
118MP0003868_abnormal_feces_composition0.59356780
119MP0001800_abnormal_humoral_immune0.59017558
120MP0009333_abnormal_splenocyte_physiolog0.58931709
121MP0000604_amyloidosis0.58481452
122MP0005257_abnormal_intraocular_pressure0.57956745
123MP0003698_abnormal_male_reproductive0.57920064
124MP0002998_abnormal_bone_remodeling0.57796267
125MP0001881_abnormal_mammary_gland0.57611842
126MP0010030_abnormal_orbit_morphology0.57514949
127MP0010307_abnormal_tumor_latency0.57354602
128MP0001216_abnormal_epidermal_layer0.56137612
129MP0001845_abnormal_inflammatory_respons0.55283355
130MP0001765_abnormal_ion_homeostasis0.54244984
131MP0009765_abnormal_xenobiotic_induced0.54242614
132MP0003091_abnormal_cell_migration0.52754535
133MP0003718_maternal_effect0.50553146
134MP0009115_abnormal_fat_cell0.48949787
135MP0003315_abnormal_perineum_morphology0.48866104
136MP0005167_abnormal_blood-brain_barrier0.47033162
137MP0009764_decreased_sensitivity_to0.46469756
138MP0000579_abnormal_nail_morphology0.45507280
139MP0005376_homeostasis/metabolism_phenot0.45475220
140MP0003879_abnormal_hair_cell0.45054978
141MP0005501_abnormal_skin_physiology0.43781424
142MP0005319_abnormal_enzyme/_coenzyme0.43037280
143MP0005166_decreased_susceptibility_to0.42498874
144MP0000383_abnormal_hair_follicle0.41757272
145MP0001764_abnormal_homeostasis0.41130903
146MP0000377_abnormal_hair_follicle0.40945441
147MP0005187_abnormal_penis_morphology0.39248179
148MP0001533_abnormal_skeleton_physiology0.38513884
149MP0009642_abnormal_blood_homeostasis0.37282569

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)7.44430257
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.58018172
3Acanthocytosis (HP:0001927)6.52893261
4Hypobetalipoproteinemia (HP:0003563)6.10383234
5Hydroxyprolinuria (HP:0003080)5.75473890
6Abnormality of proline metabolism (HP:0010907)5.75473890
7Amelogenesis imperfecta (HP:0000705)5.49177260
8Malnutrition (HP:0004395)5.17064064
9Hyperactive renin-angiotensin system (HP:0000841)4.99834458
10Conjugated hyperbilirubinemia (HP:0002908)4.87597034
11Autoimmune thrombocytopenia (HP:0001973)4.73652806
12Right ventricular cardiomyopathy (HP:0011663)4.65301880
13Cupped ribs (HP:0000887)4.61278223
14Decreased circulating renin level (HP:0003351)4.33517384
15Hemorrhage of the eye (HP:0011885)4.24023606
16Increased IgE level (HP:0003212)4.06144440
17Poikilocytosis (HP:0004447)4.03266828
18Hyperkalemia (HP:0002153)3.93026429
19Hyperglycinuria (HP:0003108)3.87168301
20Fat malabsorption (HP:0002630)3.84145810
21Hypolipoproteinemia (HP:0010981)3.73948199
22Pigmentary retinal degeneration (HP:0001146)3.66646287
23Abnormality of renin-angiotensin system (HP:0000847)3.61413873
24Abnormality of chloride homeostasis (HP:0011422)3.58091178
25Facial shape deformation (HP:0011334)3.51807442
26Potter facies (HP:0002009)3.51807442
27Autoimmune hemolytic anemia (HP:0001890)3.49456108
28Widely patent fontanelles and sutures (HP:0004492)3.46039460
29Chronic diarrhea (HP:0002028)3.43020858
30Deep venous thrombosis (HP:0002625)3.35296594
31Flattened epiphyses (HP:0003071)3.33295972
32Abdominal distention (HP:0003270)3.25286373
33Flat acetabular roof (HP:0003180)3.23760224
34Abnormality of the distal phalanx of the thumb (HP:0009617)3.13056114
35Increased mean platelet volume (HP:0011877)3.10601135
36Bilateral sensorineural hearing impairment (HP:0008619)3.04313030
37Hypercholesterolemia (HP:0003124)2.93224634
38Abnormality of the gastric mucosa (HP:0004295)2.87867046
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.84201910
40Abnormality of aromatic amino acid family metabolism (HP:0004338)2.83649113
41Colitis (HP:0002583)2.76676818
42Xanthomatosis (HP:0000991)2.76356748
43Visceral angiomatosis (HP:0100761)2.74290048
44Tongue fasciculations (HP:0001308)2.71668626
45Abnormality of potassium homeostasis (HP:0011042)2.70705193
46Abnormal biliary tract morphology (HP:0012440)2.70627185
47Hyperaldosteronism (HP:0000859)2.70172471
48Abnormal platelet volume (HP:0011876)2.69027274
49Abnormality of urine glucose concentration (HP:0011016)2.68582217
50Glycosuria (HP:0003076)2.68582217
51Abnormal glucose tolerance (HP:0001952)2.64291178
52Abnormality of carpal bone ossification (HP:0006257)2.64078727
53Hyponatremia (HP:0002902)2.64037084
54Pili torti (HP:0003777)2.62066552
55Polycythemia (HP:0001901)2.58997646
56Mildly elevated creatine phosphokinase (HP:0008180)2.58270450
57Epidermoid cyst (HP:0200040)2.54765044
58Hemangiomatosis (HP:0007461)2.53578406
59Rectal prolapse (HP:0002035)2.52749949
60Gastrointestinal dysmotility (HP:0002579)2.50127520
61Hypoplastic scapulae (HP:0000882)2.49614617
62Aplasia/Hypoplasia of the scapulae (HP:0006713)2.49614617
63Dehydration (HP:0001944)2.48350800
64Abnormality of the 1st metacarpal (HP:0010009)2.46875054
65Neonatal short-limb short stature (HP:0008921)2.46744181
66Abnormality of small intestinal villus morphology (HP:0011472)2.45586854
67Villous atrophy (HP:0011473)2.45586854
68Mesangial abnormality (HP:0001966)2.44667122
69Metabolic alkalosis (HP:0200114)2.44280170
70Ulnar bowing (HP:0003031)2.43538059
71Abnormality of the acetabulum (HP:0003170)2.43330142
72Abnormal ossification of hand bones (HP:0005921)2.41672036
73Confusion (HP:0001289)2.40858067
74Nephrolithiasis (HP:0000787)2.40198584
75Abnormal tarsal ossification (HP:0008369)2.39373735
76Muscle fibrillation (HP:0010546)2.39117843
77Asymmetric septal hypertrophy (HP:0001670)2.38503816
78Abnormality of glycine metabolism (HP:0010895)2.37007445
79Abnormality of serine family amino acid metabolism (HP:0010894)2.37007445
80Broad face (HP:0000283)2.36595430
81Palpitations (HP:0001962)2.31106364
82Syncope (HP:0001279)2.29144092
83Enlarged epiphyses (HP:0010580)2.28897147
84Intrahepatic cholestasis (HP:0001406)2.26650781
85Recurrent sinusitis (HP:0011108)2.25647230
86Severe combined immunodeficiency (HP:0004430)2.24274758
87Abnormal hand bone ossification (HP:0010660)2.24100162
88Reticulocytosis (HP:0001923)2.23733386
89Difficulty walking (HP:0002355)2.23412028
90Urethral obstruction (HP:0000796)2.23324936
91Hyperphosphaturia (HP:0003109)2.22684508
92Progressive sensorineural hearing impairment (HP:0000408)2.18613347
93Hypokalemia (HP:0002900)2.17792665
94Abnormality of the vitamin B12 metabolism (HP:0004341)2.16611080
95Neonatal death (HP:0003811)2.16440153
96Segmental peripheral demyelination/remyelination (HP:0003481)2.16325582
97Milia (HP:0001056)2.16239660
98Thoracolumbar scoliosis (HP:0002944)2.16108974
99Abnormal foot bone ossification (HP:0010675)2.15393274
100Abnormality of monocarboxylic acid metabolism (HP:0010996)2.13814161
101Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.13119202
102Distal upper limb amyotrophy (HP:0007149)2.12831044
103Upper limb amyotrophy (HP:0009129)2.12831044
104Thin bony cortex (HP:0002753)2.12171244
105Purpura (HP:0000979)2.11785070
106Biliary tract neoplasm (HP:0100574)2.10529213
107Thyroiditis (HP:0100646)2.10513738
108Abnormality of eosinophils (HP:0001879)2.10048800
109Hypoproteinemia (HP:0003075)2.08358356
110Severe visual impairment (HP:0001141)2.07403469
111Pustule (HP:0200039)2.06604284
112Alkalosis (HP:0001948)2.05814084
113Urinary glycosaminoglycan excretion (HP:0003541)2.05720445
114Mucopolysacchariduria (HP:0008155)2.05720445
115Distal lower limb amyotrophy (HP:0008944)2.05359586
116Onion bulb formation (HP:0003383)2.04284880
117Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02960318
118Prostate neoplasm (HP:0100787)2.02759198
119Cheilitis (HP:0100825)2.01191860
120B lymphocytopenia (HP:0010976)2.00575503
121Abnormality of B cell number (HP:0010975)2.00575503
122Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99885018
123Abnormality of polysaccharide metabolism (HP:0011012)1.99885018
124Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99885018
125Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.99498004
126Aplastic anemia (HP:0001915)1.97400969
127Chronic bronchitis (HP:0004469)1.96764324
128Abnormality of vitamin B metabolism (HP:0004340)1.96705360
129Eosinophilia (HP:0001880)1.96559949
130Bronchomalacia (HP:0002780)1.95990403
131Cone-rod dystrophy (HP:0000548)1.95665816
132Vertebral arch anomaly (HP:0008438)1.95555209
133Wide cranial sutures (HP:0010537)1.94325534
134Abnormal hair laboratory examination (HP:0003328)1.92999607
135Increased cerebral lipofuscin (HP:0011813)1.92223448
136Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.92137046
137Combined immunodeficiency (HP:0005387)1.91857755
138Gastrointestinal stroma tumor (HP:0100723)1.91178721
139Abnormality of purine metabolism (HP:0004352)1.91019772
140Hypoplasia of dental enamel (HP:0006297)1.89841992
141Congenital ichthyosiform erythroderma (HP:0007431)1.88193558
142Male infertility (HP:0003251)1.87351878
143Recurrent fungal infections (HP:0002841)1.86927932
144Parakeratosis (HP:0001036)1.86257295
145Abnormal urine phosphate concentration (HP:0012599)1.85108959
146Esophageal varix (HP:0002040)1.84768148
147Peripheral hypomyelination (HP:0007182)1.84497127
148Micronodular cirrhosis (HP:0001413)1.83936313
149Glomerulonephritis (HP:0000099)1.83052352
150Increased neuronal autofluorescent lipopigment (HP:0002074)1.81887128
151Stomach cancer (HP:0012126)1.81871424
152Short 1st metacarpal (HP:0010034)1.81793551
153Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.81793551
154Subcapsular cataract (HP:0000523)1.80914787
155Alopecia of scalp (HP:0002293)1.80579192
156Fatigue (HP:0012378)1.79386434
157Abnormality of vitamin metabolism (HP:0100508)1.79308750
158Gastrointestinal inflammation (HP:0004386)1.79106240
159Hypoalbuminemia (HP:0003073)1.78700278
160Abnormal albumin level (HP:0012116)1.78700278
161Dysostosis multiplex (HP:0000943)1.78037956
162Abnormality of the fingertips (HP:0001211)1.77210808
163Progressive hearing impairment (HP:0001730)1.76004880
164Abnormality of the proximal phalanges of the hand (HP:0009834)1.75900969
165Overlapping toe (HP:0001845)1.75868912
166Delayed epiphyseal ossification (HP:0002663)1.74782471
167Petechiae (HP:0000967)1.74669302
168Abnormality of the thoracic spine (HP:0100711)1.74126117
169J-shaped sella turcica (HP:0002680)1.72019311
170Cerebral aneurysm (HP:0004944)1.71808223
171Focal motor seizures (HP:0011153)1.71590923
172Abnormality of the lumbar spine (HP:0100712)1.70109691
173Abnormality of the nasal mucosa (HP:0000433)1.68779954
174Thoracic kyphosis (HP:0002942)1.68717741
175Abnormality of sodium homeostasis (HP:0010931)1.68533918
176Spinal cord compression (HP:0002176)1.66367136
177Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66240360
178Inflammation of the large intestine (HP:0002037)1.65836705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.63895663
2MST44.84306336
3MAP3K104.29507194
4STK38L4.05559006
5MST1R3.36219623
6LMTK23.34562331
7TRIB33.07382448
8EPHA22.90737114
9AKT32.90582437
10NME12.83574378
11GRK62.77021870
12PRKD32.26563961
13WNK42.26064225
14PRKG22.24817704
15MAP3K22.24653594
16PIK3CA2.16643019
17STK382.07182411
18ICK2.06646932
19FER2.04945183
20LATS12.02295934
21NUAK11.99982161
22RIPK11.95581542
23MAP2K21.85028825
24PTK61.74724687
25PRPF4B1.74295166
26EPHB11.73742484
27SIK11.71050197
28MAP3K141.61215857
29EEF2K1.55311491
30SMG11.45045088
31MAP3K31.31692131
32RIPK41.30569040
33ACVR1B1.29882603
34STK101.28561759
35TYK21.25526735
36PAK31.20530245
37EPHA31.20514936
38PRKAA21.20149778
39PKN21.19005279
40MATK1.18277484
41TAOK11.14238657
42EPHB21.13231189
43IRAK31.12908067
44DDR21.11517071
45PRKCI1.07185954
46ERN11.06967110
47MAPK151.03828469
48MET1.03685429
49PTK21.01854705
50BMX0.98170412
51STK30.91538331
52CDK120.85970111
53CHUK0.84580326
54MAP3K70.83255064
55BRD40.81756453
56WNK10.79542370
57ZAK0.77191123
58TBK10.77180080
59SIK20.75077375
60NEK20.75020772
61CAMK1D0.74279503
62FGFR40.72260157
63BMPR20.71336250
64NLK0.70918474
65PDPK10.70043033
66PDGFRA0.69257158
67FGFR30.69133845
68TAOK30.68650163
69ERBB20.68197362
70MAP2K10.65719883
71MAP3K80.64745377
72JAK10.64602293
73CDC42BPA0.63158717
74IRAK40.61984370
75NME20.61793046
76TTK0.61434047
77MTOR0.60208197
78TNK20.60205148
79MARK20.58354591
80TESK20.57277254
81CAMK1G0.54254370
82TAOK20.53136729
83PRKAA10.51358498
84MYLK0.51220839
85IKBKE0.50946450
86TESK10.50667815
87SGK30.48297500
88KSR20.47487718
89DYRK1B0.47384569
90PDK10.47132522
91IKBKB0.45713700
92PDK20.45089139
93MAPKAPK20.44258552
94STK40.44154007
95RPS6KA20.42288529
96CDK70.39929252
97MAPK110.38123614
98MAP4K10.38029094
99JAK30.36449343
100PDK30.35920331
101PDK40.35920331
102PIK3CG0.35525073
103PAK40.33606139
104ERBB30.32442077
105CAMK2D0.31898468
106MAP2K60.30823854
107DMPK0.30287499
108ROCK10.29020742
109GSK3A0.28607785
110RPS6KC10.28254929
111RPS6KL10.28254929
112PRKCZ0.28130750
113TYRO30.28081827
114ZAP700.27945174
115CDK60.27592126
116MAP3K130.26715952
117MAP3K10.25636919
118PRKCD0.25633546
119MAPKAPK30.24723351
120CDK90.24604329
121MAPK80.24593408
122RET0.23872295
123SRC0.23752973
124MAPK10.23511359
125STK390.23500996
126IRAK10.23457447
127JAK20.23240770
128MAPK30.22971631
129MAP2K30.22793948
130PRKD10.22537963
131CSK0.22303991
132LATS20.21969235
133SCYL20.19840688
134MAP3K110.19631754
135CAMK2G0.19400266
136MELK0.19311263
137AURKB0.18933176
138INSRR0.18810266
139CSNK1A10.18621291
140NEK60.17835892
141RPS6KA60.17364980
142PDGFRB0.15651651
143PLK40.15564643

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.34818491
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.72503729
3Renin-angiotensin system_Homo sapiens_hsa046144.49054798
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.38739488
5Vitamin digestion and absorption_Homo sapiens_hsa049773.98467514
6Other glycan degradation_Homo sapiens_hsa005113.94052157
7Mineral absorption_Homo sapiens_hsa049783.72785784
8Caffeine metabolism_Homo sapiens_hsa002323.68493293
9Sulfur metabolism_Homo sapiens_hsa009203.18821409
10Galactose metabolism_Homo sapiens_hsa000522.90229005
11Starch and sucrose metabolism_Homo sapiens_hsa005002.87299517
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.76520392
13Phenylalanine metabolism_Homo sapiens_hsa003602.40121556
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.17540902
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.12835441
16Protein digestion and absorption_Homo sapiens_hsa049742.03751905
17Folate biosynthesis_Homo sapiens_hsa007902.03467661
18Bile secretion_Homo sapiens_hsa049761.97580551
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.93119306
20Histidine metabolism_Homo sapiens_hsa003401.85625852
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.66923202
22Fructose and mannose metabolism_Homo sapiens_hsa000511.63337809
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55406666
24VEGF signaling pathway_Homo sapiens_hsa043701.40434285
25Sphingolipid metabolism_Homo sapiens_hsa006001.34452621
26Dorso-ventral axis formation_Homo sapiens_hsa043201.32536467
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31612372
28Acute myeloid leukemia_Homo sapiens_hsa052211.27846636
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.27613539
30Glutathione metabolism_Homo sapiens_hsa004801.26844350
31ABC transporters_Homo sapiens_hsa020101.22741947
32PPAR signaling pathway_Homo sapiens_hsa033201.19943772
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.18302180
34Tyrosine metabolism_Homo sapiens_hsa003501.13726678
35N-Glycan biosynthesis_Homo sapiens_hsa005101.09965717
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02702125
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.01325699
38Tryptophan metabolism_Homo sapiens_hsa003801.00183622
39Glycerolipid metabolism_Homo sapiens_hsa005611.00133218
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98535247
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97806559
42Selenocompound metabolism_Homo sapiens_hsa004500.94477930
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92952082
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.89936921
45Chronic myeloid leukemia_Homo sapiens_hsa052200.89833564
46Endometrial cancer_Homo sapiens_hsa052130.89611543
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88782846
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.87418865
49Tight junction_Homo sapiens_hsa045300.86120994
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.86056578
51Pancreatic cancer_Homo sapiens_hsa052120.82953324
52Complement and coagulation cascades_Homo sapiens_hsa046100.81188137
53Arginine and proline metabolism_Homo sapiens_hsa003300.81060131
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80085407
55Arginine biosynthesis_Homo sapiens_hsa002200.80053994
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79226532
57Fatty acid degradation_Homo sapiens_hsa000710.78471608
58Chemical carcinogenesis_Homo sapiens_hsa052040.75697113
59Lysine degradation_Homo sapiens_hsa003100.73677431
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.71545056
61Non-small cell lung cancer_Homo sapiens_hsa052230.71377808
62Lysosome_Homo sapiens_hsa041420.68621219
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68531887
64B cell receptor signaling pathway_Homo sapiens_hsa046620.65063692
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61583272
66Taste transduction_Homo sapiens_hsa047420.60272342
67Adherens junction_Homo sapiens_hsa045200.58803757
68Notch signaling pathway_Homo sapiens_hsa043300.58647277
69HIF-1 signaling pathway_Homo sapiens_hsa040660.58381206
70Pentose phosphate pathway_Homo sapiens_hsa000300.58154521
71ErbB signaling pathway_Homo sapiens_hsa040120.57784501
72Influenza A_Homo sapiens_hsa051640.57324524
73beta-Alanine metabolism_Homo sapiens_hsa004100.53617250
74Retinol metabolism_Homo sapiens_hsa008300.53068782
75Viral myocarditis_Homo sapiens_hsa054160.52861452
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51755073
77Fatty acid metabolism_Homo sapiens_hsa012120.51595265
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50970815
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50479376
80Type II diabetes mellitus_Homo sapiens_hsa049300.50130840
81Insulin signaling pathway_Homo sapiens_hsa049100.49482225
82Hepatitis C_Homo sapiens_hsa051600.49077286
83Leishmaniasis_Homo sapiens_hsa051400.46921964
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46207904
85Tuberculosis_Homo sapiens_hsa051520.45227402
86Estrogen signaling pathway_Homo sapiens_hsa049150.44500668
87Insulin resistance_Homo sapiens_hsa049310.44100337
88Amoebiasis_Homo sapiens_hsa051460.43765690
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.43490535
90Thyroid hormone synthesis_Homo sapiens_hsa049180.43289762
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.43044457
92Osteoclast differentiation_Homo sapiens_hsa043800.42952891
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.41725843
94AMPK signaling pathway_Homo sapiens_hsa041520.40170524
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39821689
96mTOR signaling pathway_Homo sapiens_hsa041500.38352022
97Prostate cancer_Homo sapiens_hsa052150.38317946
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37588206
99Butanoate metabolism_Homo sapiens_hsa006500.36548757
100Biosynthesis of amino acids_Homo sapiens_hsa012300.36465675
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35896705
102Gastric acid secretion_Homo sapiens_hsa049710.35678391
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33652171
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33338651
105TNF signaling pathway_Homo sapiens_hsa046680.32203206
106African trypanosomiasis_Homo sapiens_hsa051430.32114507
107Salivary secretion_Homo sapiens_hsa049700.31375875
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.29220188
109Apoptosis_Homo sapiens_hsa042100.27859952
110Small cell lung cancer_Homo sapiens_hsa052220.27517488
111Carbon metabolism_Homo sapiens_hsa012000.26627173
112Toxoplasmosis_Homo sapiens_hsa051450.26477965
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24884536
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.24378345
115Pyruvate metabolism_Homo sapiens_hsa006200.24177584
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23510496
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23318559
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22666045
119Salmonella infection_Homo sapiens_hsa051320.21413833
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21067808
121Nitrogen metabolism_Homo sapiens_hsa009100.20942606
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20721429
123Pancreatic secretion_Homo sapiens_hsa049720.19979935
124Fatty acid biosynthesis_Homo sapiens_hsa000610.19580993
125Peroxisome_Homo sapiens_hsa041460.19167586
126Sulfur relay system_Homo sapiens_hsa041220.18134651
127GnRH signaling pathway_Homo sapiens_hsa049120.18100469
128Linoleic acid metabolism_Homo sapiens_hsa005910.17825755
129TGF-beta signaling pathway_Homo sapiens_hsa043500.16708387
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15654392
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.15199118
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.14654534
133Renin secretion_Homo sapiens_hsa049240.13955426
134Vibrio cholerae infection_Homo sapiens_hsa051100.13865184
135Thyroid cancer_Homo sapiens_hsa052160.13654302
136Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.12551122
137Metabolic pathways_Homo sapiens_hsa011000.12490160
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.11896171
139Inositol phosphate metabolism_Homo sapiens_hsa005620.11550335
140Arachidonic acid metabolism_Homo sapiens_hsa005900.10920410
141Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.10614855
142Bladder cancer_Homo sapiens_hsa052190.10463820
143Choline metabolism in cancer_Homo sapiens_hsa052310.08890230
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.08871167
145Hematopoietic cell lineage_Homo sapiens_hsa046400.08254855
146Prolactin signaling pathway_Homo sapiens_hsa049170.07274910

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