GAL3ST3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.27982023
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.81642975
3ionotropic glutamate receptor signaling pathway (GO:0035235)4.74888832
4presynaptic membrane assembly (GO:0097105)4.58895048
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.50969073
6vocalization behavior (GO:0071625)4.36854689
7protein localization to synapse (GO:0035418)4.31628943
8postsynaptic membrane organization (GO:0001941)4.31295284
9neuron cell-cell adhesion (GO:0007158)4.26275214
10glutamate receptor signaling pathway (GO:0007215)4.26248318
11presynaptic membrane organization (GO:0097090)4.13428367
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.10437233
13synaptic transmission, glutamatergic (GO:0035249)4.07983827
14establishment of mitochondrion localization (GO:0051654)3.98050472
15nucleobase catabolic process (GO:0046113)3.96499151
16regulation of glutamate receptor signaling pathway (GO:1900449)3.89242127
17neuronal action potential propagation (GO:0019227)3.88634085
18negative regulation of synaptic transmission, GABAergic (GO:0032229)3.82427829
19gamma-aminobutyric acid transport (GO:0015812)3.69026553
20startle response (GO:0001964)3.66530137
21neuron-neuron synaptic transmission (GO:0007270)3.64679219
22G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.60270132
23synaptic vesicle exocytosis (GO:0016079)3.51733282
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.48298277
25neurotransmitter-gated ion channel clustering (GO:0072578)3.46603951
26positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.43556554
27gamma-aminobutyric acid signaling pathway (GO:0007214)3.41327948
28righting reflex (GO:0060013)3.41235358
29regulation of excitatory postsynaptic membrane potential (GO:0060079)3.40915819
30long-term memory (GO:0007616)3.39477478
31negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.35754456
32dendritic spine morphogenesis (GO:0060997)3.31239128
33positive regulation of dendritic spine development (GO:0060999)3.30570182
34positive regulation of membrane potential (GO:0045838)3.29360968
35neurofilament cytoskeleton organization (GO:0060052)3.24661462
36response to pheromone (GO:0019236)3.24527710
37regulation of postsynaptic membrane potential (GO:0060078)3.23989445
38synaptic vesicle maturation (GO:0016188)3.23438744
39locomotory exploration behavior (GO:0035641)3.22549079
40regulation of neuronal synaptic plasticity (GO:0048168)3.19555392
41chaperone-mediated protein transport (GO:0072321)3.19374455
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18211657
43positive regulation of dendritic spine morphogenesis (GO:0061003)3.18065523
44central nervous system projection neuron axonogenesis (GO:0021952)3.17926541
45protein-cofactor linkage (GO:0018065)3.15535607
46transmission of nerve impulse (GO:0019226)3.14132674
47neuron recognition (GO:0008038)3.13340770
48cerebral cortex radially oriented cell migration (GO:0021799)3.11727450
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.11597101
50regulation of long-term neuronal synaptic plasticity (GO:0048169)3.09118279
51regulation of synaptic vesicle exocytosis (GO:2000300)3.07432944
52L-serine metabolic process (GO:0006563)3.06380028
53regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05132293
54positive regulation of synapse assembly (GO:0051965)3.03104403
55L-amino acid import (GO:0043092)3.01972814
56positive regulation of synaptic transmission, GABAergic (GO:0032230)3.00729598
57regulation of gene silencing by RNA (GO:0060966)3.00113419
58regulation of posttranscriptional gene silencing (GO:0060147)3.00113419
59regulation of gene silencing by miRNA (GO:0060964)3.00113419
60mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.98435051
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.97814910
62glutamate secretion (GO:0014047)2.97170499
63exploration behavior (GO:0035640)2.96899741
64regulation of synaptic vesicle transport (GO:1902803)2.96553563
65behavioral response to cocaine (GO:0048148)2.90319180
66regulation of synaptic transmission, glutamatergic (GO:0051966)2.90026151
67establishment of integrated proviral latency (GO:0075713)2.86170823
68central nervous system neuron axonogenesis (GO:0021955)2.85829898
69cell migration in hindbrain (GO:0021535)2.84351770
70membrane hyperpolarization (GO:0060081)2.84261326
71regulation of respiratory system process (GO:0044065)2.81880808
72auditory behavior (GO:0031223)2.81696037
73membrane depolarization (GO:0051899)2.80443974
74response to auditory stimulus (GO:0010996)2.79702856
75synaptic vesicle docking involved in exocytosis (GO:0016081)2.78881417
76regulation of synapse assembly (GO:0051963)2.77591635
77regulation of respiratory gaseous exchange (GO:0043576)2.76812931
78protein localization to cilium (GO:0061512)2.75777484
79regulation of vesicle fusion (GO:0031338)2.75109981
80retinal cone cell development (GO:0046549)2.74996642
81layer formation in cerebral cortex (GO:0021819)2.74980151
82regulation of synaptic transmission, GABAergic (GO:0032228)2.74727993
83axonal fasciculation (GO:0007413)2.74131632
84serotonin receptor signaling pathway (GO:0007210)2.72977832
85negative regulation of telomere maintenance (GO:0032205)2.72873481
86regulation of synapse structural plasticity (GO:0051823)2.72526549
87learning (GO:0007612)2.72511613
88behavioral defense response (GO:0002209)2.72471281
89behavioral fear response (GO:0001662)2.72471281
90cerebellar Purkinje cell differentiation (GO:0021702)2.72252713
91regulation of neurotransmitter secretion (GO:0046928)2.71729957
92negative regulation of DNA recombination (GO:0045910)2.70199766
93long-term synaptic potentiation (GO:0060291)2.70167992
94regulation of double-strand break repair via homologous recombination (GO:0010569)2.69200544
95regulation of dendritic spine morphogenesis (GO:0061001)2.68526147
96DNA damage response, detection of DNA damage (GO:0042769)2.68501079
97short-term memory (GO:0007614)2.68496401
98mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.67896859
99mechanosensory behavior (GO:0007638)2.67501997
100synapse assembly (GO:0007416)2.67306873
101regulation of dendritic spine development (GO:0060998)2.65506509
102response to histamine (GO:0034776)2.65004598
103regulation of synapse maturation (GO:0090128)2.64978568
104regulation of voltage-gated calcium channel activity (GO:1901385)2.64857610
105regulation of synaptic plasticity (GO:0048167)2.63528215
106adult walking behavior (GO:0007628)2.63508278
107behavioral response to nicotine (GO:0035095)2.62593625
108cAMP catabolic process (GO:0006198)2.61260582
109fear response (GO:0042596)2.59429848
110nonmotile primary cilium assembly (GO:0035058)2.58048863
111positive regulation of neurotransmitter secretion (GO:0001956)2.57112743
112regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.56957048
113amino acid import (GO:0043090)2.56072388
114detection of calcium ion (GO:0005513)2.55857636
115cyclic nucleotide catabolic process (GO:0009214)2.55155560
116innervation (GO:0060384)2.54719243
117regulation of timing of cell differentiation (GO:0048505)2.54307093
118G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.52932861
119lateral sprouting from an epithelium (GO:0060601)2.52604648
120synaptic vesicle endocytosis (GO:0048488)2.52585145
121energy coupled proton transport, down electrochemical gradient (GO:0015985)2.52364597
122ATP synthesis coupled proton transport (GO:0015986)2.52364597
123neurotransmitter secretion (GO:0007269)2.52072830
124calcium ion import (GO:0070509)2.51560581
125associative learning (GO:0008306)2.51000619
126positive regulation of meiosis (GO:0045836)2.50604630
127regulation of synapse organization (GO:0050807)2.50437288
128dendritic spine organization (GO:0097061)2.50388829
129axon ensheathment in central nervous system (GO:0032291)2.50190508
130central nervous system myelination (GO:0022010)2.50190508
131positive regulation of mitochondrial fission (GO:0090141)2.50142062
132sequestering of actin monomers (GO:0042989)2.50140849
133paraxial mesoderm development (GO:0048339)2.50061054
134regulation of inositol phosphate biosynthetic process (GO:0010919)2.49520971
135establishment of viral latency (GO:0019043)2.48578068
136cell communication by electrical coupling (GO:0010644)2.48189783
137hippocampus development (GO:0021766)2.47667721
138establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.43223526
139mitochondrion transport along microtubule (GO:0047497)2.43223526
140histone arginine methylation (GO:0034969)2.42562213
141respiratory electron transport chain (GO:0022904)2.40922292
142regulation of mitochondrial translation (GO:0070129)2.38902244
143calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.36169296
144regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.35287001
145ephrin receptor signaling pathway (GO:0048013)2.34726182
146neuronal ion channel clustering (GO:0045161)2.34702156
147synapse organization (GO:0050808)2.34305793
148electron transport chain (GO:0022900)2.33873247
149protein insertion into membrane (GO:0051205)2.33127548
150peptidyl-arginine omega-N-methylation (GO:0035247)2.32380130
151substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.29526468
152substrate-independent telencephalic tangential migration (GO:0021826)2.29526468
153sodium ion export (GO:0071436)2.29062897
154adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.28754890
155establishment of synaptic vesicle localization (GO:0097480)2.27342091
156synaptic vesicle transport (GO:0048489)2.27342091
157establishment of vesicle localization (GO:0051650)2.23631398
158negative regulation of microtubule polymerization (GO:0031115)2.21850218
159regulation of development, heterochronic (GO:0040034)2.21356195
160regulation of feeding behavior (GO:0060259)2.20578292
161generation of neurons (GO:0048699)2.20114696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.88642284
2GBX2_23144817_ChIP-Seq_PC3_Human4.02945343
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11086360
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89371053
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79969478
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.70606988
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.67717137
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60775905
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54952492
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54952492
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.54765007
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53166446
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50848472
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31105973
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27638010
16* EZH2_27294783_Chip-Seq_ESCs_Mouse2.25192027
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20370347
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19512204
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.14552810
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14337737
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12913568
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12831050
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.11424456
24CBX2_27304074_Chip-Seq_ESCs_Mouse2.03305458
25REST_21632747_ChIP-Seq_MESCs_Mouse2.01788237
26TAF15_26573619_Chip-Seq_HEK293_Human2.01108654
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96975829
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95610704
29SOX2_16153702_ChIP-ChIP_HESCs_Human1.92415238
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.92314467
31ZNF274_21170338_ChIP-Seq_K562_Hela1.86251307
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85363656
33DROSHA_22980978_ChIP-Seq_HELA_Human1.85324393
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85058751
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81732128
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.81142573
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75112938
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73048213
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68258040
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68097221
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66539413
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66259807
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.64985202
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64497516
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62640073
46RNF2_27304074_Chip-Seq_NSC_Mouse1.62406761
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62138577
48P300_19829295_ChIP-Seq_ESCs_Human1.60893658
49VDR_22108803_ChIP-Seq_LS180_Human1.59446739
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.58502270
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57108455
52IRF1_19129219_ChIP-ChIP_H3396_Human1.56361987
53SMAD4_21799915_ChIP-Seq_A2780_Human1.56091759
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.55871021
55AR_21572438_ChIP-Seq_LNCaP_Human1.55264816
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54834820
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51332380
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.50665129
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50050781
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49953912
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49868629
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49006130
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44665733
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.44248191
65IGF1R_20145208_ChIP-Seq_DFB_Human1.43655556
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.43517417
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.43387479
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.42983037
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41565207
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40249468
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.38832637
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38140879
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.38027148
74JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37667611
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.36246357
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36053275
77NANOG_16153702_ChIP-ChIP_HESCs_Human1.35416974
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.35400820
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34224023
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.33993558
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33246655
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31224540
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31024745
84MYC_18940864_ChIP-ChIP_HL60_Human1.30165057
85RARB_27405468_Chip-Seq_BRAIN_Mouse1.29208904
86* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28293068
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.27732867
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24208087
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24208087
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24062417
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.23721648
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23040909
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22982230
94P53_22387025_ChIP-Seq_ESCs_Mouse1.22616864
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22275622
96* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22058695
97FUS_26573619_Chip-Seq_HEK293_Human1.19594921
98RING1B_27294783_Chip-Seq_ESCs_Mouse1.18630628
99AR_25329375_ChIP-Seq_VCAP_Human1.17778189
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17212515
101* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17093550
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17011842
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.16201040
104ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15788060
105ER_23166858_ChIP-Seq_MCF-7_Human1.15559900
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15335268
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14525798
108STAT3_23295773_ChIP-Seq_U87_Human1.14456722
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13265927
110EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13001560
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12208107
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11728355
113STAT3_18555785_Chip-Seq_ESCs_Mouse1.11287090
114XRN2_22483619_ChIP-Seq_HELA_Human1.11044689
115RING1B_27294783_Chip-Seq_NPCs_Mouse1.10916559
116YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09253429
117EWS_26573619_Chip-Seq_HEK293_Human1.09250160
118P300_18555785_Chip-Seq_ESCs_Mouse1.08709195
119* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08648331
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08565610
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08198739
122TCF4_23295773_ChIP-Seq_U87_Human1.08045731
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07970573
124NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07279379
125SOX2_18555785_Chip-Seq_ESCs_Mouse1.07161859
126NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07144966
127NMYC_18555785_Chip-Seq_ESCs_Mouse1.07110889
128POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06817065
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06636461
130RUNX2_22187159_ChIP-Seq_PCA_Human1.06546359
131RUNX1_27457419_Chip-Seq_LIVER_Mouse1.06466902
132EZH2_27294783_Chip-Seq_NPCs_Mouse1.05479149
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05369089
134HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04702340
135NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03898858
136* GABP_19822575_ChIP-Seq_HepG2_Human1.03128660
137LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02844920
138P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02611804
139* YY1_21170310_ChIP-Seq_MESCs_Mouse1.02549850
140GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01629303
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01609118
142MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01588501
143MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00890257
144SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00885542
145OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00104461
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99883734
147TAL1_26923725_Chip-Seq_HPCs_Mouse0.99717211
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.99598927
149MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99434802
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98504506
151E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98363259
152MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97824177
153MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97320225
154TP53_18474530_ChIP-ChIP_U2OS_Human0.96683037
155CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95572229
156PU1_27457419_Chip-Seq_LIVER_Mouse0.95563089
157OCT4_18555785_Chip-Seq_ESCs_Mouse0.95240321
158TTF2_22483619_ChIP-Seq_HELA_Human0.94200397
159SOX9_26525672_Chip-Seq_HEART_Mouse0.93964367
160SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93448317
161POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91570468
162KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91123941

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.51806843
2MP0003880_abnormal_central_pattern4.48530910
3MP0003635_abnormal_synaptic_transmissio3.10158345
4MP0003136_yellow_coat_color2.98900645
5MP0005423_abnormal_somatic_nervous2.97655519
6MP0009745_abnormal_behavioral_response2.89758081
7MP0001188_hyperpigmentation2.88865217
8MP0006292_abnormal_olfactory_placode2.78314773
9MP0001486_abnormal_startle_reflex2.74876414
10MP0002063_abnormal_learning/memory/cond2.55260932
11MP0002064_seizures2.50222441
12MP0005409_darkened_coat_color2.42354416
13MP0001968_abnormal_touch/_nociception2.37925014
14MP0002572_abnormal_emotion/affect_behav2.36758783
15MP0009046_muscle_twitch2.35690371
16MP0002272_abnormal_nervous_system2.32805047
17MP0002735_abnormal_chemical_nociception2.28050324
18MP0004270_analgesia2.26549759
19MP0008877_abnormal_DNA_methylation2.08175598
20MP0003121_genomic_imprinting2.03871163
21MP0002102_abnormal_ear_morphology1.99104581
22MP0002653_abnormal_ependyma_morphology1.92599691
23MP0002734_abnormal_mechanical_nocicepti1.92412898
24MP0000778_abnormal_nervous_system1.89873378
25MP0002067_abnormal_sensory_capabilities1.89191291
26MP0002736_abnormal_nociception_after1.84370928
27MP0001501_abnormal_sleep_pattern1.82856284
28MP0006276_abnormal_autonomic_nervous1.81990143
29MP0001440_abnormal_grooming_behavior1.81138171
30MP0005551_abnormal_eye_electrophysiolog1.79753360
31MP0002557_abnormal_social/conspecific_i1.78195882
32MP0003787_abnormal_imprinting1.77829396
33MP0004742_abnormal_vestibular_system1.76929977
34MP0005646_abnormal_pituitary_gland1.76868704
35MP0010030_abnormal_orbit_morphology1.73782053
36MP0005645_abnormal_hypothalamus_physiol1.73018738
37MP0001984_abnormal_olfaction1.70054854
38MP0005171_absent_coat_pigmentation1.69179739
39MP0002184_abnormal_innervation1.63696984
40MP0002822_catalepsy1.62337516
41MP0001986_abnormal_taste_sensitivity1.60294172
42MP0004142_abnormal_muscle_tone1.57558990
43MP0008569_lethality_at_weaning1.53783392
44MP0001970_abnormal_pain_threshold1.52677994
45MP0003878_abnormal_ear_physiology1.52073631
46MP0005377_hearing/vestibular/ear_phenot1.52073631
47MP0001905_abnormal_dopamine_level1.45375807
48MP0000566_synostosis1.45336992
49MP0003879_abnormal_hair_cell1.44626343
50MP0001502_abnormal_circadian_rhythm1.41849655
51MP0003890_abnormal_embryonic-extraembry1.37586602
52MP0000026_abnormal_inner_ear1.36231201
53MP0002882_abnormal_neuron_morphology1.35773150
54MP0001963_abnormal_hearing_physiology1.35164720
55MP0002733_abnormal_thermal_nociception1.33813929
56MP0000015_abnormal_ear_pigmentation1.32558074
57MP0002876_abnormal_thyroid_physiology1.32242245
58MP0002233_abnormal_nose_morphology1.29891108
59MP0001293_anophthalmia1.28661698
60MP0003119_abnormal_digestive_system1.27764979
61MP0003937_abnormal_limbs/digits/tail_de1.26490642
62MP0002638_abnormal_pupillary_reflex1.26022977
63MP0001529_abnormal_vocalization1.25951181
64MP0004924_abnormal_behavior1.20604445
65MP0005386_behavior/neurological_phenoty1.20604445
66MP0004381_abnormal_hair_follicle1.19833121
67MP0010386_abnormal_urinary_bladder1.19116096
68MP0002752_abnormal_somatic_nervous1.16315999
69MP0006072_abnormal_retinal_apoptosis1.14658223
70MP0001299_abnormal_eye_distance/1.14513598
71MP0008058_abnormal_DNA_repair1.14249617
72MP0000955_abnormal_spinal_cord1.13975595
73MP0002066_abnormal_motor_capabilities/c1.13315626
74MP0003693_abnormal_embryo_hatching1.12463592
75MP0000631_abnormal_neuroendocrine_gland1.12422318
76MP0003938_abnormal_ear_development1.09951996
77MP0001485_abnormal_pinna_reflex1.07446532
78MP0003567_abnormal_fetal_cardiomyocyte1.06579431
79MP0004811_abnormal_neuron_physiology1.03987998
80MP0005253_abnormal_eye_physiology1.03824374
81MP0002229_neurodegeneration1.00987450
82MP0004885_abnormal_endolymph1.00550712
83MP0002697_abnormal_eye_size0.99989611
84MP0003137_abnormal_impulse_conducting0.99077183
85MP0002277_abnormal_respiratory_mucosa0.97868325
86MP0009672_abnormal_birth_weight0.97310626
87MP0004145_abnormal_muscle_electrophysio0.95642155
88MP0003011_delayed_dark_adaptation0.93287001
89MP0002152_abnormal_brain_morphology0.91602682
90MP0008932_abnormal_embryonic_tissue0.90929613
91MP0005248_abnormal_Harderian_gland0.89505077
92MP0003755_abnormal_palate_morphology0.87978717
93MP0000920_abnormal_myelination0.84277768
94MP0005174_abnormal_tail_pigmentation0.83927214
95MP0004133_heterotaxia0.83349426
96MP0005499_abnormal_olfactory_system0.83298512
97MP0005394_taste/olfaction_phenotype0.83298512
98MP0001286_abnormal_eye_development0.82618199
99MP0000049_abnormal_middle_ear0.80923443
100MP0000537_abnormal_urethra_morphology0.80258786
101MP0003385_abnormal_body_wall0.79881212
102MP0003122_maternal_imprinting0.79550792
103MP0008260_abnormal_autophagy0.78739531
104MP0002254_reproductive_system_inflammat0.78471353
105MP0002249_abnormal_larynx_morphology0.78244211
106MP0001346_abnormal_lacrimal_gland0.78154122
107MP0005391_vision/eye_phenotype0.76289582
108MP0009379_abnormal_foot_pigmentation0.75556657
109MP0006035_abnormal_mitochondrial_morpho0.75394531
110MP0004085_abnormal_heartbeat0.72101960
111MP0001664_abnormal_digestion0.72044650
112MP0003633_abnormal_nervous_system0.71766011
113MP0003123_paternal_imprinting0.71644715
114MP0002081_perinatal_lethality0.69715613
115MP0005195_abnormal_posterior_eye0.69689464
116MP0003631_nervous_system_phenotype0.68563989
117MP0001177_atelectasis0.67224229
118MP0003634_abnormal_glial_cell0.66467263
119MP0002069_abnormal_eating/drinking_beha0.66162894
120MP0002751_abnormal_autonomic_nervous0.65514603
121MP0004484_altered_response_of0.64812896
122MP0004215_abnormal_myocardial_fiber0.64173937
123MP0005595_abnormal_vascular_smooth0.63251267
124MP0005379_endocrine/exocrine_gland_phen0.62340385
125MP0000681_abnormal_thyroid_gland0.61786835
126MP0000751_myopathy0.61685556
127MP0008789_abnormal_olfactory_epithelium0.58881285
128MP0008995_early_reproductive_senescence0.56329686
129MP0003861_abnormal_nervous_system0.55476531

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.58919273
2Febrile seizures (HP:0002373)4.57504004
3Abnormality of the labia minora (HP:0012880)4.37723018
4Epileptic encephalopathy (HP:0200134)3.90992320
5Myokymia (HP:0002411)3.88695746
6Focal seizures (HP:0007359)3.82159332
7Progressive cerebellar ataxia (HP:0002073)3.45996321
8Absent/shortened dynein arms (HP:0200106)3.23845873
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.23845873
10Congenital stationary night blindness (HP:0007642)3.18044524
11Broad-based gait (HP:0002136)3.00037030
12Abnormal ciliary motility (HP:0012262)2.96296318
13Gaze-evoked nystagmus (HP:0000640)2.90432957
14Septo-optic dysplasia (HP:0100842)2.87290345
15Failure to thrive in infancy (HP:0001531)2.85143995
16Limb dystonia (HP:0002451)2.83902641
17Poor suck (HP:0002033)2.79445460
18Atonic seizures (HP:0010819)2.76176457
19Hepatoblastoma (HP:0002884)2.73107113
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.70946962
21Hyperglycinemia (HP:0002154)2.62634547
22Abnormal hair whorl (HP:0010721)2.61834850
23Visual hallucinations (HP:0002367)2.61589385
24Dialeptic seizures (HP:0011146)2.60874662
25Abnormal respiratory epithelium morphology (HP:0012253)2.58896882
26Abnormal respiratory motile cilium morphology (HP:0005938)2.58896882
27Absence seizures (HP:0002121)2.58269465
28Generalized tonic-clonic seizures (HP:0002069)2.55849759
29Abnormal respiratory motile cilium physiology (HP:0012261)2.55230802
30Humeroradial synostosis (HP:0003041)2.55045591
31Synostosis involving the elbow (HP:0003938)2.55045591
32Decreased central vision (HP:0007663)2.53502909
33Absent speech (HP:0001344)2.52895010
34Cortical dysplasia (HP:0002539)2.52027618
35Colon cancer (HP:0003003)2.50730090
36Shoulder girdle muscle weakness (HP:0003547)2.48660146
37Vaginal atresia (HP:0000148)2.43117446
38Optic nerve hypoplasia (HP:0000609)2.40091689
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39371480
40Genital tract atresia (HP:0001827)2.37546500
41Absent septum pellucidum (HP:0001331)2.33622790
42Hyperventilation (HP:0002883)2.33188596
43Acute necrotizing encephalopathy (HP:0006965)2.30276576
44Aplasia/Hypoplasia of the fovea (HP:0008060)2.28792949
45Hypoplasia of the fovea (HP:0007750)2.28792949
46Action tremor (HP:0002345)2.28562755
47Excessive salivation (HP:0003781)2.25965120
48Drooling (HP:0002307)2.25965120
49Rib fusion (HP:0000902)2.24534605
50Congenital sensorineural hearing impairment (HP:0008527)2.20986192
51Specific learning disability (HP:0001328)2.17825038
52Attenuation of retinal blood vessels (HP:0007843)2.16725923
53Abnormal rod and cone electroretinograms (HP:0008323)2.13823608
54Abnormal mitochondria in muscle tissue (HP:0008316)2.12636172
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12259080
56True hermaphroditism (HP:0010459)2.12091802
57Partial duplication of thumb phalanx (HP:0009944)2.11507645
58Nonprogressive disorder (HP:0003680)2.11478005
59Gait imbalance (HP:0002141)2.11324488
60Broad foot (HP:0001769)2.10975527
61Lissencephaly (HP:0001339)2.07483032
62Medial flaring of the eyebrow (HP:0010747)2.06925283
63Abnormality of the lower motor neuron (HP:0002366)2.05844921
64Generalized hypotonia (HP:0001290)2.04953544
65Fetal akinesia sequence (HP:0001989)2.04585034
66Abnormal eating behavior (HP:0100738)2.04542968
67Choanal stenosis (HP:0000452)2.03045699
68Abnormality of the hip-girdle musculature (HP:0001445)2.00593063
69Abnormality of the musculature of the pelvis (HP:0001469)2.00593063
70Acute encephalopathy (HP:0006846)2.00574232
71Abnormality of the septum pellucidum (HP:0007375)1.98441050
72Rimmed vacuoles (HP:0003805)1.98352628
73Split foot (HP:0001839)1.97949910
74Sleep apnea (HP:0010535)1.97323061
75Decreased circulating renin level (HP:0003351)1.96651448
76Retinal dysplasia (HP:0007973)1.96637503
77Dysdiadochokinesis (HP:0002075)1.95009916
78Anophthalmia (HP:0000528)1.94879944
79Genetic anticipation (HP:0003743)1.94840286
80Dysmetria (HP:0001310)1.94668550
81Mutism (HP:0002300)1.94597411
82Labial hypoplasia (HP:0000066)1.94542234
83Pelvic girdle muscle weakness (HP:0003749)1.92779109
84Mitochondrial inheritance (HP:0001427)1.92365280
85Maternal diabetes (HP:0009800)1.91846165
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90427608
87Obstructive sleep apnea (HP:0002870)1.89734975
88Hemiparesis (HP:0001269)1.89509763
89Hypoplastic female external genitalia (HP:0012815)1.89266776
90Increased corneal curvature (HP:0100692)1.88678574
91Keratoconus (HP:0000563)1.88678574
92Nephronophthisis (HP:0000090)1.88557382
93Aplasia/Hypoplasia of the brainstem (HP:0007362)1.88462109
94Hypoplasia of the brainstem (HP:0002365)1.88462109
95Abnormality of the fovea (HP:0000493)1.88295873
96Increased hepatocellular lipid droplets (HP:0006565)1.88179322
97Amyotrophic lateral sclerosis (HP:0007354)1.86574592
98Tubulointerstitial nephritis (HP:0001970)1.85650173
99Abnormality of salivation (HP:0100755)1.85516563
100Severe visual impairment (HP:0001141)1.84615822
101Esotropia (HP:0000565)1.84009072
102Patchy hypopigmentation of hair (HP:0011365)1.83623536
103Congenital primary aphakia (HP:0007707)1.82605211
104Chromsome breakage (HP:0040012)1.82174498
105White forelock (HP:0002211)1.82156987
106Scrotal hypoplasia (HP:0000046)1.81879282
107Growth hormone deficiency (HP:0000824)1.81605450
108Nephrogenic diabetes insipidus (HP:0009806)1.81542537
109Impaired vibration sensation in the lower limbs (HP:0002166)1.81380970
110Peripheral hypomyelination (HP:0007182)1.80284525
111Aplasia/Hypoplasia of the lens (HP:0008063)1.80211924
112Atrophy/Degeneration involving motor neurons (HP:0007373)1.80203222
113Protruding tongue (HP:0010808)1.79680954
114Aplasia cutis congenita (HP:0001057)1.79286909
115Bifid tongue (HP:0010297)1.78243889
116Anomalous pulmonary venous return (HP:0010772)1.78140033
117Urinary urgency (HP:0000012)1.77987305
118Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77426080
119Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.77377637
120Supernumerary spleens (HP:0009799)1.77170021
121Poor coordination (HP:0002370)1.76269264
122Dyschromatopsia (HP:0007641)1.76207154
123Partial duplication of the phalanx of hand (HP:0009999)1.76087214
124Optic disc pallor (HP:0000543)1.75656781
125Lipid accumulation in hepatocytes (HP:0006561)1.75251412
126Pancreatic fibrosis (HP:0100732)1.75243720
127Blue irides (HP:0000635)1.74443676
128Hemivertebrae (HP:0002937)1.74350420
129Progressive macrocephaly (HP:0004481)1.73570183
130Spastic gait (HP:0002064)1.73069475
131Abnormality of the renal medulla (HP:0100957)1.72151709
132Amblyopia (HP:0000646)1.72102992
133Bradycardia (HP:0001662)1.71840263
134Hyperglycinuria (HP:0003108)1.71650688
135Aplasia involving bones of the upper limbs (HP:0009823)1.71491215
136Aplasia of the phalanges of the hand (HP:0009802)1.71491215
137Aplasia involving bones of the extremities (HP:0009825)1.71491215
138Inability to walk (HP:0002540)1.71459029
139Micropenis (HP:0000054)1.71173532
140Median cleft lip (HP:0000161)1.70958223
141Anxiety (HP:0000739)1.70586848
142Spastic tetraplegia (HP:0002510)1.70461650
143Abnormality of macular pigmentation (HP:0008002)1.70331058
144Duplicated collecting system (HP:0000081)1.69074752
145Thickened helices (HP:0000391)1.68379928
146Duplication of thumb phalanx (HP:0009942)1.68294041
147Postaxial hand polydactyly (HP:0001162)1.67982521
148Stenosis of the external auditory canal (HP:0000402)1.67980600
149Abnormality of the corticospinal tract (HP:0002492)1.67692632
150Molar tooth sign on MRI (HP:0002419)1.67342296
151Abnormality of midbrain morphology (HP:0002418)1.67342296
152Short tibia (HP:0005736)1.67319761
153Hepatocellular necrosis (HP:0001404)1.66273871
154Medulloblastoma (HP:0002885)1.66221486
155Increased serum pyruvate (HP:0003542)1.66108485
156Aplasia/Hypoplasia of the tibia (HP:0005772)1.65293919
157Increased CSF lactate (HP:0002490)1.65137915
158Polyphagia (HP:0002591)1.64751271
159Conical tooth (HP:0000698)1.64129396
160Palpebral edema (HP:0100540)1.64017090
161Esophageal atresia (HP:0002032)1.63744524
162Abnormality of glycine metabolism (HP:0010895)1.63694273
163Abnormality of serine family amino acid metabolism (HP:0010894)1.63694273
164Abnormal EKG (HP:0003115)1.63473671
165Atelectasis (HP:0100750)1.62603786
166Scanning speech (HP:0002168)1.62543492
167Urinary bladder sphincter dysfunction (HP:0002839)1.61793142

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.77935123
2NTRK33.37852175
3EPHA43.22921730
4TNIK2.86818330
5PRPF4B2.73941379
6MAP2K72.68439250
7MARK12.51482120
8CDC72.50586762
9SRPK12.42746511
10TRIM282.14867214
11MAPK132.13166716
12MUSK2.06356722
13CSNK1G22.00383223
14CSNK1G31.92694807
15NTRK21.85980543
16WNK31.84717697
17CSNK1G11.73492560
18CSNK1A1L1.71131707
19MKNK21.71011233
20STK161.69729038
21BMPR21.59509193
22BCKDK1.57649258
23FES1.57307118
24BLK1.55443888
25MAP3K41.54217098
26NEK61.51399504
27MAP3K121.45357783
28MINK11.43615560
29PINK11.32801926
30TSSK61.28612477
31DYRK31.28045611
32INSRR1.25828867
33PKN11.19989431
34CDK31.19583881
35CAMK11.19405296
36SIK31.18850863
37NEK11.17876048
38RIPK41.17777713
39CAMK2A1.17672589
40PHKG21.16428520
41PHKG11.16428520
42STK38L1.15647765
43GRK11.12691529
44PAK61.11393500
45PNCK1.09971369
46IRAK21.09370174
47CLK11.08273243
48DAPK21.05985372
49TXK1.05875100
50GRK51.04375832
51ADRBK21.04228186
52CAMK2B1.02181245
53CDK51.02009524
54PLK21.01593757
55MAP4K21.00144474
56DYRK1A0.99429102
57GRK70.98000494
58PLK30.97613798
59MAP3K90.95301760
60UHMK10.94611527
61ZAK0.94324467
62TNK20.92269082
63LIMK10.91890734
64OXSR10.89403965
65PRKCG0.88593572
66SGK4940.88237686
67SGK2230.88237686
68NTRK10.88061142
69SIK20.87481803
70EPHB20.87037396
71BCR0.85608290
72PRKCE0.85333347
73TTK0.85223205
74PRKD20.84723687
75EPHA30.83651399
76MKNK10.81950109
77MARK20.81150541
78VRK10.80968799
79EIF2AK20.80592399
80FGFR20.79837091
81BMPR1B0.79523220
82VRK20.78004521
83PLK10.77677089
84MAP3K130.77605398
85STK380.77060084
86DYRK20.76234990
87CDK190.76136141
88TYRO30.76067832
89MAP3K110.74791316
90YES10.73419228
91IRAK40.73414476
92PLK40.72963838
93CAMK2D0.72571349
94AURKA0.71061603
95FGR0.70023880
96IRAK10.68352386
97STK390.67756828
98SGK20.67666370
99AKT30.67387610
100ARAF0.66819454
101STK110.65699777
102DYRK1B0.65343508
103KSR10.63632008
104SGK10.63015160
105CSNK1E0.61432425
106MAP2K40.60881945
107PRKCZ0.58357970
108BUB10.57521479
109ATR0.54925713
110FER0.53698973
111CSNK1A10.53570312
112TLK10.53478945
113IRAK30.53242177
114MAPK90.52712531
115TESK10.52452252
116ERBB30.51786204
117CSNK1D0.50490216
118NME10.48934831
119DAPK10.48505582
120DMPK0.48262880
121PRKG10.47975041
122CDC42BPA0.47710716
123PRKACA0.47147077
124PTK2B0.46547684
125CDK180.46166535
126CDK140.42875946
127CAMKK20.41731704
128MAPK70.41326461
129PAK30.41096546
130PRKD30.40982484
131CAMK2G0.40876785
132CAMK40.40181112
133CAMK1G0.40174504
134MAP3K100.40134669
135CDK150.40005641
136PIK3CA0.39846171
137CHEK20.39768786
138MAPK120.39675981
139FYN0.39297597
140PRKDC0.39157105
141ADRBK10.38611372
142CDK11A0.38421166
143AURKB0.36744403
144AKT20.36017734
145TIE10.35758400
146FGFR10.35693100
147GSK3B0.34040670
148CDK20.34005343

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.33045439
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82423269
3Morphine addiction_Homo sapiens_hsa050322.78536763
4Phototransduction_Homo sapiens_hsa047442.68807308
5Glutamatergic synapse_Homo sapiens_hsa047242.63936305
6Circadian entrainment_Homo sapiens_hsa047132.55491485
7GABAergic synapse_Homo sapiens_hsa047272.51394125
8Olfactory transduction_Homo sapiens_hsa047402.43257145
9Taste transduction_Homo sapiens_hsa047422.41375667
10Synaptic vesicle cycle_Homo sapiens_hsa047212.36322043
11Serotonergic synapse_Homo sapiens_hsa047262.13387316
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.11477424
13Salivary secretion_Homo sapiens_hsa049701.90737836
14Protein export_Homo sapiens_hsa030601.90366785
15Amphetamine addiction_Homo sapiens_hsa050311.88482007
16Steroid biosynthesis_Homo sapiens_hsa001001.83675877
17Long-term potentiation_Homo sapiens_hsa047201.82280117
18Calcium signaling pathway_Homo sapiens_hsa040201.80793951
19Insulin secretion_Homo sapiens_hsa049111.71819527
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70309812
21Cholinergic synapse_Homo sapiens_hsa047251.69745104
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68359048
23Dopaminergic synapse_Homo sapiens_hsa047281.65435704
24Spliceosome_Homo sapiens_hsa030401.61571999
25Long-term depression_Homo sapiens_hsa047301.61515846
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.58866035
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55463002
28Axon guidance_Homo sapiens_hsa043601.54620866
29RNA polymerase_Homo sapiens_hsa030201.54337257
30Base excision repair_Homo sapiens_hsa034101.50279891
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46515790
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43528148
33Oxytocin signaling pathway_Homo sapiens_hsa049211.42151846
34Collecting duct acid secretion_Homo sapiens_hsa049661.41288300
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40702092
36Gastric acid secretion_Homo sapiens_hsa049711.40165788
37Cardiac muscle contraction_Homo sapiens_hsa042601.39131704
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31755564
39Cocaine addiction_Homo sapiens_hsa050301.31703777
40Mismatch repair_Homo sapiens_hsa034301.29458230
41cAMP signaling pathway_Homo sapiens_hsa040241.28843878
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28686687
43Renin secretion_Homo sapiens_hsa049241.27199857
44Proteasome_Homo sapiens_hsa030501.26086691
45Biosynthesis of amino acids_Homo sapiens_hsa012301.23165916
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19921676
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16804330
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13628058
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12916059
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12894376
51DNA replication_Homo sapiens_hsa030301.12500661
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.11924975
53Fatty acid elongation_Homo sapiens_hsa000621.09941933
54Selenocompound metabolism_Homo sapiens_hsa004501.08269743
55Oocyte meiosis_Homo sapiens_hsa041141.07889201
56mRNA surveillance pathway_Homo sapiens_hsa030151.07013058
57Oxidative phosphorylation_Homo sapiens_hsa001901.06917314
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04418048
59Vitamin B6 metabolism_Homo sapiens_hsa007501.03400480
60GnRH signaling pathway_Homo sapiens_hsa049121.02145724
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01982175
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01307527
63Hippo signaling pathway_Homo sapiens_hsa043901.00922860
64RNA degradation_Homo sapiens_hsa030180.99142471
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99031652
66Basal transcription factors_Homo sapiens_hsa030220.98994508
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98776602
68Pyruvate metabolism_Homo sapiens_hsa006200.98000065
69Sphingolipid metabolism_Homo sapiens_hsa006000.97405362
70Carbon metabolism_Homo sapiens_hsa012000.97258890
71Propanoate metabolism_Homo sapiens_hsa006400.97108730
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96208589
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95513051
74Ribosome_Homo sapiens_hsa030100.95170611
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93990230
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.93750632
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92725848
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90646053
79Melanogenesis_Homo sapiens_hsa049160.89949730
80RNA transport_Homo sapiens_hsa030130.89814555
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89348712
82Alzheimers disease_Homo sapiens_hsa050100.88798465
83Dilated cardiomyopathy_Homo sapiens_hsa054140.87871971
84Ether lipid metabolism_Homo sapiens_hsa005650.84781940
85Gap junction_Homo sapiens_hsa045400.84468593
86Rheumatoid arthritis_Homo sapiens_hsa053230.81802180
87Folate biosynthesis_Homo sapiens_hsa007900.81153728
88Autoimmune thyroid disease_Homo sapiens_hsa053200.80754298
89Wnt signaling pathway_Homo sapiens_hsa043100.79940341
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79884650
91Ras signaling pathway_Homo sapiens_hsa040140.79849347
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78438432
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78403344
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78223481
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76914686
96Pancreatic secretion_Homo sapiens_hsa049720.76687128
97Circadian rhythm_Homo sapiens_hsa047100.74618082
98Non-homologous end-joining_Homo sapiens_hsa034500.74210328
99ErbB signaling pathway_Homo sapiens_hsa040120.74141113
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71946403
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71882462
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70974777
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68591091
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68166184
105MAPK signaling pathway_Homo sapiens_hsa040100.67297496
106Vibrio cholerae infection_Homo sapiens_hsa051100.67061283
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66604638
108Pyrimidine metabolism_Homo sapiens_hsa002400.66409335
109Fanconi anemia pathway_Homo sapiens_hsa034600.65250745
110Nitrogen metabolism_Homo sapiens_hsa009100.64589231
111Ovarian steroidogenesis_Homo sapiens_hsa049130.64417427
112Parkinsons disease_Homo sapiens_hsa050120.64399925
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.64294921
114Tight junction_Homo sapiens_hsa045300.64169646
115Choline metabolism in cancer_Homo sapiens_hsa052310.61569007
116Cell cycle_Homo sapiens_hsa041100.61502939
117Allograft rejection_Homo sapiens_hsa053300.61444626
118Butanoate metabolism_Homo sapiens_hsa006500.60739075
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60527477
120Type II diabetes mellitus_Homo sapiens_hsa049300.60237313
121Huntingtons disease_Homo sapiens_hsa050160.60188605
122Nucleotide excision repair_Homo sapiens_hsa034200.60156117
123Graft-versus-host disease_Homo sapiens_hsa053320.59998418
124Arachidonic acid metabolism_Homo sapiens_hsa005900.59389026
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58787096
126African trypanosomiasis_Homo sapiens_hsa051430.55759592
127Arginine and proline metabolism_Homo sapiens_hsa003300.55309470
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54866644
129Asthma_Homo sapiens_hsa053100.53712624
130Type I diabetes mellitus_Homo sapiens_hsa049400.51265453
131Metabolic pathways_Homo sapiens_hsa011000.50461064
132Fatty acid metabolism_Homo sapiens_hsa012120.50247561
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49994960
134Purine metabolism_Homo sapiens_hsa002300.49759493
135Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49730336
136Chemokine signaling pathway_Homo sapiens_hsa040620.48965618
137Inositol phosphate metabolism_Homo sapiens_hsa005620.47151066
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.46447464
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46332003
140Rap1 signaling pathway_Homo sapiens_hsa040150.45878042
141Estrogen signaling pathway_Homo sapiens_hsa049150.44513348
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43333874
143Dorso-ventral axis formation_Homo sapiens_hsa043200.41502958
144Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39935842
145Alcoholism_Homo sapiens_hsa050340.38609971
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37858215
147Mineral absorption_Homo sapiens_hsa049780.36392404
148Linoleic acid metabolism_Homo sapiens_hsa005910.35412612
149Regulation of autophagy_Homo sapiens_hsa041400.33327534
150Melanoma_Homo sapiens_hsa052180.33054622
151Hedgehog signaling pathway_Homo sapiens_hsa043400.32048846
152Basal cell carcinoma_Homo sapiens_hsa052170.30160886
153Glioma_Homo sapiens_hsa052140.29525093
154alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29263974

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