GALC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.18852422
2glomerular visceral epithelial cell development (GO:0072015)5.16677479
3glomerular epithelial cell development (GO:0072310)4.86404996
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.75693602
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.75693602
6modulation by symbiont of host immune response (GO:0052553)4.75693602
7positive regulation by symbiont of host defense response (GO:0052509)4.75693602
8modulation by symbiont of host defense response (GO:0052031)4.75693602
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.75693602
10glomerular basement membrane development (GO:0032836)4.27903503
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.20771159
12cilium movement (GO:0003341)3.96143012
13axonemal dynein complex assembly (GO:0070286)3.94659177
14cell adhesion mediated by integrin (GO:0033627)3.82643058
15epithelial cilium movement (GO:0003351)3.78832960
16regulation of interferon-beta biosynthetic process (GO:0045357)3.70525812
17macrophage activation involved in immune response (GO:0002281)3.58671492
18protein localization to endosome (GO:0036010)3.43307928
19positive regulation of p38MAPK cascade (GO:1900745)3.36121578
20apoptotic cell clearance (GO:0043277)3.17710715
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.13640659
22response to host immune response (GO:0052572)3.13640659
23motile cilium assembly (GO:0044458)3.04857378
24pyrimidine nucleobase catabolic process (GO:0006208)3.04529842
25positive regulation of mast cell activation involved in immune response (GO:0033008)3.03565448
26positive regulation of mast cell degranulation (GO:0043306)3.03565448
27cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.02585353
28response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.02502808
29response to host (GO:0075136)3.02502808
30response to host defenses (GO:0052200)3.02502808
31positive regulation of mast cell activation (GO:0033005)3.00909539
32nucleobase catabolic process (GO:0046113)2.99569266
33response to lipoprotein particle (GO:0055094)2.96288292
34positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.93094800
35microglial cell activation (GO:0001774)2.92988868
36organic cation transport (GO:0015695)2.91788669
37positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.86806104
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.85942939
39drug transmembrane transport (GO:0006855)2.84161598
40toxin transport (GO:1901998)2.81851660
41axoneme assembly (GO:0035082)2.80265100
42protein localization to cilium (GO:0061512)2.77002708
43neutrophil activation involved in immune response (GO:0002283)2.76653915
44surfactant homeostasis (GO:0043129)2.75129378
45regulation of membrane protein ectodomain proteolysis (GO:0051043)2.73273622
46urate metabolic process (GO:0046415)2.70703374
47stress fiber assembly (GO:0043149)2.68716403
48negative regulation of interleukin-12 production (GO:0032695)2.67859924
49proline transport (GO:0015824)2.67526712
50macroautophagy (GO:0016236)2.61983819
51regulation of integrin-mediated signaling pathway (GO:2001044)2.60342020
52negative regulation of mast cell activation (GO:0033004)2.60017689
53aminoglycoside antibiotic metabolic process (GO:0030647)2.57234165
54keratan sulfate catabolic process (GO:0042340)2.56085496
55positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.54981680
56phosphate ion transport (GO:0006817)2.54174251
57regulation of mast cell activation (GO:0033003)2.53772019
58T-helper 1 type immune response (GO:0042088)2.52208475
59regulation of p38MAPK cascade (GO:1900744)2.48278081
60response to thyroid hormone (GO:0097066)2.48268847
61estrogen biosynthetic process (GO:0006703)2.47428654
62detection of molecule of bacterial origin (GO:0032490)2.46796824
63sodium ion export (GO:0071436)2.46339704
64neural tube formation (GO:0001841)2.43659522
65L-amino acid import (GO:0043092)2.43221749
66I-kappaB phosphorylation (GO:0007252)2.42428201
67cellular response to vitamin (GO:0071295)2.42415628
68wound healing, spreading of epidermal cells (GO:0035313)2.41937605
69mannose metabolic process (GO:0006013)2.41315345
70cellular extravasation (GO:0045123)2.41284358
71excretion (GO:0007588)2.40489912
72cytoskeletal anchoring at plasma membrane (GO:0007016)2.40164186
73quaternary ammonium group transport (GO:0015697)2.37958594
74regulation of mast cell activation involved in immune response (GO:0033006)2.37918478
75macrophage activation (GO:0042116)2.36860120
76peptide catabolic process (GO:0043171)2.35947242
77positive regulation of macrophage cytokine production (GO:0060907)2.35727160
78positive regulation of leukocyte degranulation (GO:0043302)2.35028445
79androgen biosynthetic process (GO:0006702)2.33051858
80positive regulation of cell adhesion mediated by integrin (GO:0033630)2.32803059
81drug transport (GO:0015893)2.32637656
82negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.31967230
83negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.31830221
84negative regulation of cell killing (GO:0031342)2.31830221
85benzene-containing compound metabolic process (GO:0042537)2.31796271
86cellular response to thyroid hormone stimulus (GO:0097067)2.30783053
87amyloid precursor protein catabolic process (GO:0042987)2.30427871
88activated T cell proliferation (GO:0050798)2.30081237
89glucocorticoid biosynthetic process (GO:0006704)2.29600366
90regulation of heat generation (GO:0031650)2.29522786
91regulation of early endosome to late endosome transport (GO:2000641)2.29492316
92toxin metabolic process (GO:0009404)2.28694893
93positive regulation of cellular amide metabolic process (GO:0034250)2.28591865
94regulation of alkaline phosphatase activity (GO:0010692)2.28299470
95negative regulation of interleukin-1 beta production (GO:0032691)2.26809184
96cellular potassium ion homeostasis (GO:0030007)2.26791428
97cilium organization (GO:0044782)2.26328485
98regulation of interferon-alpha production (GO:0032647)2.25718616
99growth hormone receptor signaling pathway (GO:0060396)2.25712365
100regulation of cholesterol storage (GO:0010885)2.25320728
101cellular response to vitamin D (GO:0071305)2.25320598
102negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.24234460
103regulation of clathrin-mediated endocytosis (GO:2000369)2.23610227
104cilium assembly (GO:0042384)2.22635687
105bone resorption (GO:0045453)2.21983906
106regulation of cilium movement (GO:0003352)2.21225327
107hydrogen peroxide biosynthetic process (GO:0050665)2.20829897
108regulation of mast cell degranulation (GO:0043304)2.20662695
109semaphorin-plexin signaling pathway (GO:0071526)2.20521437
110nerve growth factor signaling pathway (GO:0038180)2.20372099
111lipoprotein transport (GO:0042953)2.20306667
112positive regulation of osteoblast proliferation (GO:0033690)2.19961154
113positive regulation of toll-like receptor signaling pathway (GO:0034123)2.19512945
114cellular response to growth hormone stimulus (GO:0071378)2.18916301
115positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.18764816
116clathrin coat assembly (GO:0048268)2.18220029
117negative regulation of interleukin-1 production (GO:0032692)2.17960475
118regulation of macrophage cytokine production (GO:0010935)2.16958980
119glycoside metabolic process (GO:0016137)2.16488841
120glycosphingolipid biosynthetic process (GO:0006688)2.16357564
121superoxide anion generation (GO:0042554)2.16109119
122positive regulation of heat generation (GO:0031652)2.15314297
123intraciliary transport (GO:0042073)2.14770644
124negative regulation of response to reactive oxygen species (GO:1901032)2.14427147
125negative regulation of immunoglobulin mediated immune response (GO:0002890)2.14222043
126negative regulation of B cell mediated immunity (GO:0002713)2.14222043
127fibroblast migration (GO:0010761)2.14151505
128renal filtration (GO:0097205)2.13497025
129phosphate ion transmembrane transport (GO:0035435)2.13312469
130ganglioside metabolic process (GO:0001573)2.12230487
131cellular response to antibiotic (GO:0071236)2.12211182
132presynaptic membrane assembly (GO:0097105)2.11994926
133behavioral response to nicotine (GO:0035095)2.11745856
134intracellular lipid transport (GO:0032365)2.10465196
135phagosome maturation (GO:0090382)2.10453116
136positive regulation of interferon-alpha production (GO:0032727)2.09617112
137negative regulation of cytosolic calcium ion concentration (GO:0051481)2.09396688
138regulation of microtubule-based movement (GO:0060632)2.09249268
139cell wall macromolecule catabolic process (GO:0016998)2.09040403
140positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.08591388
141vitamin D metabolic process (GO:0042359)2.08436408
142regulation of fever generation (GO:0031620)2.08062296
143regulation of hydrogen peroxide-induced cell death (GO:1903205)2.07953412
144cell wall macromolecule metabolic process (GO:0044036)2.07495862
145reactive oxygen species biosynthetic process (GO:1903409)2.06876871
146response to peptidoglycan (GO:0032494)2.06689984
147brain morphogenesis (GO:0048854)2.06100542
148cerebellar Purkinje cell differentiation (GO:0021702)2.05614012
149left/right axis specification (GO:0070986)2.05578140
150nonmotile primary cilium assembly (GO:0035058)2.05518671
151interleukin-6-mediated signaling pathway (GO:0070102)2.04696750
152calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.04068800
153amino sugar catabolic process (GO:0046348)2.03090020
154presynaptic membrane organization (GO:0097090)2.02822529
155positive regulation of male gonad development (GO:2000020)2.02426051
156sulfation (GO:0051923)2.02308430
157response to fluid shear stress (GO:0034405)2.02133299
158neutrophil activation (GO:0042119)2.02068188
159positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.02027538
160dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.01598737
161positive regulation of bone resorption (GO:0045780)2.01435993
162positive regulation of bone remodeling (GO:0046852)2.01435993
163endocytic recycling (GO:0032456)2.00638770
164axonal fasciculation (GO:0007413)2.00546241
165amino acid import (GO:0043090)2.00467909
166positive regulation of regulated secretory pathway (GO:1903307)2.00254680
167regulation of beta-amyloid formation (GO:1902003)2.00247957
168metanephric epithelium development (GO:0072207)2.00041203
169granulocyte activation (GO:0036230)1.99585965
170regulation of mononuclear cell migration (GO:0071675)1.99441238
171leukocyte migration involved in inflammatory response (GO:0002523)1.99420655
172basement membrane organization (GO:0071711)1.99222347
173cilium morphogenesis (GO:0060271)1.98972665
174neutrophil mediated immunity (GO:0002446)1.98920740
175parturition (GO:0007567)1.98354670
176cellular response to ethanol (GO:0071361)1.98077982
177glucocorticoid metabolic process (GO:0008211)1.97798256
178response to mercury ion (GO:0046689)1.96845922
179regulation of male gonad development (GO:2000018)1.96557129
180regulation of MHC class II biosynthetic process (GO:0045346)1.96501795
181progesterone metabolic process (GO:0042448)1.96293449
182metanephric nephron epithelium development (GO:0072243)1.95526539
183positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)1.95439904
184myeloid cell activation involved in immune response (GO:0002275)1.95364830
185prostate gland growth (GO:0060736)1.95268945
186epithelial cell differentiation involved in prostate gland development (GO:0060742)1.95240854
187neurotransmitter-gated ion channel clustering (GO:0072578)1.94030287
188regulation of tolerance induction (GO:0002643)1.93916230

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.81778176
2EZH2_22144423_ChIP-Seq_EOC_Human2.74117401
3GBX2_23144817_ChIP-Seq_PC3_Human2.63566664
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.34359052
5IRF8_27001747_Chip-Seq_BMDM_Mouse2.25335237
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.22301333
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22064982
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15976042
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.12384208
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12079928
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06084439
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05208190
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.01041748
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93421363
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91646797
16TAF15_26573619_Chip-Seq_HEK293_Human1.88514859
17VDR_22108803_ChIP-Seq_LS180_Human1.79263474
18* IGF1R_20145208_ChIP-Seq_DFB_Human1.78500140
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.76531448
20* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73686786
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.73088557
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70834416
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.70135475
24VDR_24787735_ChIP-Seq_THP-1_Human1.69683050
25GATA2_21666600_ChIP-Seq_HMVEC_Human1.68102712
26* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67437270
27* P300_19829295_ChIP-Seq_ESCs_Human1.62376026
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60358027
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.60075094
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.57061438
31SMAD4_21799915_ChIP-Seq_A2780_Human1.55015342
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.54456316
33SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52752064
34ZNF274_21170338_ChIP-Seq_K562_Hela1.50402610
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49963113
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49942288
37* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49081288
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46532077
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43027377
40* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41159661
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.39141134
42CLOCK_20551151_ChIP-Seq_293T_Human1.38764649
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38673552
44* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38301901
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38184700
46* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37566340
47SPI1_23127762_ChIP-Seq_K562_Human1.36745203
48NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.36474504
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35890989
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35890989
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.34549640
52AHR_22903824_ChIP-Seq_MCF-7_Human1.33961793
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33863157
54* ER_23166858_ChIP-Seq_MCF-7_Human1.33260696
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33010895
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33010895
57* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32695617
58* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31581623
59STAT3_23295773_ChIP-Seq_U87_Human1.30271104
60CJUN_26792858_Chip-Seq_BT549_Human1.28254099
61RXR_22108803_ChIP-Seq_LS180_Human1.27988025
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27480884
63AR_25329375_ChIP-Seq_VCAP_Human1.27113657
64* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27059413
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25894677
66* EP300_21415370_ChIP-Seq_HL-1_Mouse1.25458808
67* SMAD3_21741376_ChIP-Seq_EPCs_Human1.24564464
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24000335
69* REST_21632747_ChIP-Seq_MESCs_Mouse1.23216334
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.21979073
71* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21898991
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20766376
73WT1_19549856_ChIP-ChIP_CCG9911_Human1.20392965
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.19708195
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.19678320
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19017633
77CBP_20019798_ChIP-Seq_JUKART_Human1.19017633
78TCF4_23295773_ChIP-Seq_U87_Human1.18986572
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17918244
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16971210
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16861018
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.16698324
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16036766
84BCAT_22108803_ChIP-Seq_LS180_Human1.15120514
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14603411
86* RUNX2_22187159_ChIP-Seq_PCA_Human1.12990955
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.12726581
88* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12543547
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12517156
90GATA1_19941826_ChIP-Seq_K562_Human1.12072918
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11595156
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11572997
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11391945
94KDM2B_26808549_Chip-Seq_K562_Human1.10711931
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10045585
96SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10020700
97MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09685709
98FOXA2_19822575_ChIP-Seq_HepG2_Human1.09616023
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09591127
100PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09074612
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08847639
102DROSHA_22980978_ChIP-Seq_HELA_Human1.08470663
103IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05703987
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05497022
105LXR_22158963_ChIP-Seq_LIVER_Mouse1.05343655
106* FLI1_21867929_ChIP-Seq_TH2_Mouse1.04913854
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04707439
108BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04569648
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04088855
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04068156
111KDM2B_26808549_Chip-Seq_REH_Human1.03932818
112RUNX_20019798_ChIP-Seq_JUKART_Human1.03588195
113SOX2_20726797_ChIP-Seq_SW620_Human1.03394646
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03105965
115JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02758683
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02367225
117TCF4_22108803_ChIP-Seq_LS180_Human1.01684170
118EZH2_27294783_Chip-Seq_NPCs_Mouse1.01564782
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00410298
120SOX2_21211035_ChIP-Seq_LN229_Gbm0.99796292
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99763198
122* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99401527
123* GATA2_19941826_ChIP-Seq_K562_Human0.99248994
124CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99145068
125TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99009771
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98998104
127FUS_26573619_Chip-Seq_HEK293_Human0.98525362
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.97589808
129P53_22387025_ChIP-Seq_ESCs_Mouse0.97552256
130EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97456796
131STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97111180
132NANOG_19829295_ChIP-Seq_ESCs_Human0.96970873
133SOX2_19829295_ChIP-Seq_ESCs_Human0.96970873
134RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96901670
135TBX20_22080862_ChIP-Seq_HEART_Mouse0.96817893
136TBX20_22328084_ChIP-Seq_HEART_Mouse0.96817893
137* PU_27001747_Chip-Seq_BMDM_Mouse0.96773630
138SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95772966
139KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95734317
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95232744
141STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95128535
142EWS_26573619_Chip-Seq_HEK293_Human0.94867028
143* TP53_18474530_ChIP-ChIP_U2OS_Human0.94770351
144SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94488546
145KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94369466
146TP63_23658742_ChIP-Seq_EP156T_Human0.94324986
147SMAD4_21741376_ChIP-Seq_EPCs_Human0.94256302
148THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94106518
149SMAD_19615063_ChIP-ChIP_OVARY_Human0.93133415
150SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92914561
151SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92086168
152CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91751761
153JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91475877
154TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90899611
155SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89914969
156NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89174486
157JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86935743
158SCL_19346495_ChIP-Seq_HPC-7_Human0.86296020
159KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83588683
160* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83476866
161CDX2_20551321_ChIP-Seq_CACO-2_Human0.82889401
162SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.82428253
163CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82324168
164FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.82076860
165SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81868635
166KDM2B_26808549_Chip-Seq_DND41_Human0.81631789
167AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81589616
168TP53_16413492_ChIP-PET_HCT116_Human0.81383841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.81495600
2MP0003172_abnormal_lysosome_physiology4.29025455
3MP0000569_abnormal_digit_pigmentation3.55995745
4MP0003300_gastrointestinal_ulcer3.37514942
5MP0003303_peritoneal_inflammation3.12324126
6MP0002653_abnormal_ependyma_morphology3.05429872
7MP0001958_emphysema2.69925792
8MP0004043_abnormal_pH_regulation2.44385203
9MP0005623_abnormal_meninges_morphology2.31754919
10MP0003191_abnormal_cellular_cholesterol2.12033865
11MP0004858_abnormal_nervous_system2.11662774
12MP0000604_amyloidosis2.11596165
13MP0009643_abnormal_urine_homeostasis1.97724450
14MP0001984_abnormal_olfaction1.97664722
15MP0003183_abnormal_peptide_metabolism1.94499620
16* MP0003690_abnormal_glial_cell1.91104072
17MP0003122_maternal_imprinting1.87401663
18MP0002136_abnormal_kidney_physiology1.82964997
19MP0001765_abnormal_ion_homeostasis1.80537984
20MP0003283_abnormal_digestive_organ1.73908159
21MP0008961_abnormal_basal_metabolism1.70794737
22MP0003075_altered_response_to1.67613216
23MP0005332_abnormal_amino_acid1.65677496
24MP0001756_abnormal_urination1.63861693
25MP0004019_abnormal_vitamin_homeostasis1.63852950
26MP0009764_decreased_sensitivity_to1.62779849
27MP0000465_gastrointestinal_hemorrhage1.61270115
28MP0002138_abnormal_hepatobiliary_system1.60446530
29MP0004147_increased_porphyrin_level1.57508579
30MP0005257_abnormal_intraocular_pressure1.52612692
31MP0008438_abnormal_cutaneous_collagen1.51304892
32MP0003787_abnormal_imprinting1.50857039
33* MP0003634_abnormal_glial_cell1.50497423
34MP0003195_calcinosis1.48737426
35MP0009840_abnormal_foam_cell1.47663704
36MP0001501_abnormal_sleep_pattern1.47629712
37MP0003880_abnormal_central_pattern1.47257591
38MP0003436_decreased_susceptibility_to1.47039880
39* MP0002419_abnormal_innate_immunity1.46565651
40MP0003091_abnormal_cell_migration1.45916331
41MP0003705_abnormal_hypodermis_morpholog1.45148211
42MP0003566_abnormal_cell_adhesion1.43742132
43MP0001486_abnormal_startle_reflex1.42296410
44MP0009046_muscle_twitch1.39376911
45MP0004272_abnormal_basement_membrane1.39249433
46MP0004270_analgesia1.38603447
47MP0003011_delayed_dark_adaptation1.37794429
48MP0000343_altered_response_to1.37305594
49MP0009745_abnormal_behavioral_response1.36900370
50MP0002148_abnormal_hypersensitivity_rea1.36664387
51MP0006054_spinal_hemorrhage1.36429124
52* MP0002064_seizures1.34946442
53MP0004883_abnormal_blood_vessel1.33936108
54MP0009278_abnormal_bone_marrow1.33846435
55* MP0000920_abnormal_myelination1.31816431
56* MP0002998_abnormal_bone_remodeling1.31014446
57MP0005360_urolithiasis1.30972377
58MP0003632_abnormal_nervous_system1.30695720
59MP0001529_abnormal_vocalization1.30176013
60MP0005310_abnormal_salivary_gland1.30159093
61MP0002572_abnormal_emotion/affect_behav1.29558615
62MP0005670_abnormal_white_adipose1.29401406
63MP0008875_abnormal_xenobiotic_pharmacok1.29111003
64MP0006276_abnormal_autonomic_nervous1.27788097
65MP0005671_abnormal_response_to1.27691324
66MP0002277_abnormal_respiratory_mucosa1.23769670
67MP0000778_abnormal_nervous_system1.22811341
68MP0005253_abnormal_eye_physiology1.22158119
69MP0005025_abnormal_response_to1.19171984
70MP0003635_abnormal_synaptic_transmissio1.17789525
71MP0002063_abnormal_learning/memory/cond1.17733220
72* MP0002135_abnormal_kidney_morphology1.17601715
73MP0001533_abnormal_skeleton_physiology1.15668874
74MP0003329_amyloid_beta_deposits1.13990046
75MP0009785_altered_susceptibility_to1.13388409
76MP0002735_abnormal_chemical_nociception1.12964861
77MP0004130_abnormal_muscle_cell1.12366081
78MP0004510_myositis1.11815215
79MP0002102_abnormal_ear_morphology1.11160980
80MP0003656_abnormal_erythrocyte_physiolo1.10757377
81MP0002168_other_aberrant_phenotype1.10648519
82MP0001970_abnormal_pain_threshold1.10540533
83* MP0003631_nervous_system_phenotype1.10505612
84MP0005166_decreased_susceptibility_to1.10317383
85MP0001986_abnormal_taste_sensitivity1.10128415
86MP0002272_abnormal_nervous_system1.09572738
87MP0002090_abnormal_vision1.09067976
88MP0004142_abnormal_muscle_tone1.09066996
89MP0002896_abnormal_bone_mineralization1.08712204
90MP0008004_abnormal_stomach_pH1.08578599
91MP0002877_abnormal_melanocyte_morpholog1.08296202
92MP0005464_abnormal_platelet_physiology1.06481805
93MP0002734_abnormal_mechanical_nocicepti1.05637840
94MP0003045_fibrosis1.05543749
95* MP0002067_abnormal_sensory_capabilities1.03445530
96MP0008877_abnormal_DNA_methylation1.03422326
97MP0005248_abnormal_Harderian_gland1.01936090
98MP0001879_abnormal_lymphatic_vessel1.01784630
99* MP0005167_abnormal_blood-brain_barrier1.00114833
100MP0004185_abnormal_adipocyte_glucose1.00068738
101MP0005551_abnormal_eye_electrophysiolog0.99647050
102MP0002733_abnormal_thermal_nociception0.98905976
103MP0001968_abnormal_touch/_nociception0.98479799
104MP0003448_altered_tumor_morphology0.97773471
105* MP0006082_CNS_inflammation0.97694795
106MP0005386_behavior/neurological_phenoty0.97201246
107MP0004924_abnormal_behavior0.97201246
108MP0000639_abnormal_adrenal_gland0.96931446
109MP0010368_abnormal_lymphatic_system0.95393055
110MP0005083_abnormal_biliary_tract0.94637715
111* MP0002452_abnormal_antigen_presenting0.94543187
112MP0010678_abnormal_skin_adnexa0.94070534
113MP0003279_aneurysm0.93379643
114MP0005164_abnormal_response_to0.92494453
115MP0005197_abnormal_uvea_morphology0.91774872
116MP0004859_abnormal_synaptic_plasticity0.91293434
117MP0000427_abnormal_hair_cycle0.91167285
118MP0002909_abnormal_adrenal_gland0.90646704
119* MP0003633_abnormal_nervous_system0.90589262
120* MP0002229_neurodegeneration0.90305858
121MP0003828_pulmonary_edema0.89603112
122MP0005636_abnormal_mineral_homeostasis0.89502436
123MP0005666_abnormal_adipose_tissue0.89497202
124MP0004742_abnormal_vestibular_system0.89218742
125* MP0002723_abnormal_immune_serum0.88941660
126MP0005595_abnormal_vascular_smooth0.88390893
127MP0001835_abnormal_antigen_presentation0.88192102
128MP0002638_abnormal_pupillary_reflex0.87716318
129MP0010386_abnormal_urinary_bladder0.87690857
130MP0002928_abnormal_bile_duct0.86903976
131* MP0003795_abnormal_bone_structure0.86790569
132MP0002295_abnormal_pulmonary_circulatio0.86678478
133MP0001440_abnormal_grooming_behavior0.86307724
134MP0000230_abnormal_systemic_arterial0.85434269
135MP0005085_abnormal_gallbladder_physiolo0.85247272
136MP0005377_hearing/vestibular/ear_phenot0.85086406
137MP0003878_abnormal_ear_physiology0.85086406
138MP0003136_yellow_coat_color0.84216263
139MP0000733_abnormal_muscle_development0.83110858
140MP0009780_abnormal_chondrocyte_physiolo0.81218661
141MP0005000_abnormal_immune_tolerance0.78493366
142MP0000383_abnormal_hair_follicle0.76953733
143MP0004885_abnormal_endolymph0.76773096
144MP0001915_intracranial_hemorrhage0.76027747
145MP0002133_abnormal_respiratory_system0.75461624
146MP0005388_respiratory_system_phenotype0.75461624
147MP0009384_cardiac_valve_regurgitation0.74887057
148* MP0005387_immune_system_phenotype0.74616473
149* MP0001790_abnormal_immune_system0.74616473
150MP0004947_skin_inflammation0.74072958
151MP0000767_abnormal_smooth_muscle0.73986048
152MP0005076_abnormal_cell_differentiation0.73912039
153MP0010307_abnormal_tumor_latency0.73745069
154MP0001845_abnormal_inflammatory_respons0.73031235
155MP0000371_diluted_coat_color0.71944006
156MP0002933_joint_inflammation0.68721080
157MP0003724_increased_susceptibility_to0.67738917
158MP0001299_abnormal_eye_distance/0.67070970
159MP0004084_abnormal_cardiac_muscle0.66609347
160* MP0008469_abnormal_protein_level0.64918471
161MP0005375_adipose_tissue_phenotype0.64874672
162* MP0002115_abnormal_skeleton_extremities0.64011060
163MP0001851_eye_inflammation0.63105052
164MP0000858_altered_metastatic_potential0.61858031
165MP0005174_abnormal_tail_pigmentation0.61558658
166MP0001849_ear_inflammation0.61049797

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)5.36588361
2Vacuolated lymphocytes (HP:0001922)4.82638351
3Dysostosis multiplex (HP:0000943)4.75762980
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.56753495
5Absent/shortened dynein arms (HP:0200106)4.55186894
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.55186894
7Abnormal ciliary motility (HP:0012262)4.46508150
8Abnormal respiratory epithelium morphology (HP:0012253)4.29717953
9Abnormal respiratory motile cilium morphology (HP:0005938)4.29717953
10Abnormal respiratory motile cilium physiology (HP:0012261)4.27788312
11Urinary glycosaminoglycan excretion (HP:0003541)4.25136456
12Mucopolysacchariduria (HP:0008155)4.25136456
13Increased circulating renin level (HP:0000848)4.21885982
14Increased neuronal autofluorescent lipopigment (HP:0002074)4.18936520
15Abnormality of mucopolysaccharide metabolism (HP:0011020)4.03955826
16Abnormality of polysaccharide metabolism (HP:0011012)4.03955826
17Abnormality of glycosaminoglycan metabolism (HP:0004371)4.03955826
18Polyphagia (HP:0002591)4.01527481
19Axonal loss (HP:0003447)3.92524252
20Hypokalemic alkalosis (HP:0001949)3.89531325
21Metabolic alkalosis (HP:0200114)3.87546593
22Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.79132159
23Rhinitis (HP:0012384)3.64147061
24Abnormality of chloride homeostasis (HP:0011422)3.60670251
25Tetany (HP:0001281)3.54463826
26Focal segmental glomerulosclerosis (HP:0000097)3.49439137
27Hypomagnesemia (HP:0002917)3.44130163
28Abnormality of glycolipid metabolism (HP:0010969)3.42489572
29Abnormality of liposaccharide metabolism (HP:0010968)3.42489572
30Abnormality of glycosphingolipid metabolism (HP:0004343)3.42489572
31Hyperactive renin-angiotensin system (HP:0000841)3.32265425
32Polyuria (HP:0000103)3.15811092
33Abnormality of macrophages (HP:0004311)3.09296470
34Chronic hepatic failure (HP:0100626)3.01287333
35Neurofibrillary tangles (HP:0002185)2.98624459
36True hermaphroditism (HP:0010459)2.98373422
37Stomatitis (HP:0010280)2.97174126
38Abnormal drinking behavior (HP:0030082)2.95246258
39Polydipsia (HP:0001959)2.95246258
40Glomerulonephritis (HP:0000099)2.94737527
41Glomerulosclerosis (HP:0000096)2.93767532
42Abnormal urine output (HP:0012590)2.93515444
43Systemic lupus erythematosus (HP:0002725)2.92275379
44Abnormality of renal excretion (HP:0011036)2.90892683
45Pancreatic fibrosis (HP:0100732)2.83537769
46Agitation (HP:0000713)2.80720401
47Recurrent abscess formation (HP:0002722)2.76928782
48Gout (HP:0001997)2.76484363
49Pancreatic cysts (HP:0001737)2.76185290
50Abnormality of magnesium homeostasis (HP:0004921)2.72727152
51Disinhibition (HP:0000734)2.71685398
52Asymmetric septal hypertrophy (HP:0001670)2.70715478
53Nephritis (HP:0000123)2.69194312
54Abnormal eating behavior (HP:0100738)2.66034631
55Mutism (HP:0002300)2.64922367
56Nephronophthisis (HP:0000090)2.63449576
57Optic neuritis (HP:0100653)2.63080695
58Retrobulbar optic neuritis (HP:0100654)2.63080695
59Molar tooth sign on MRI (HP:0002419)2.60520641
60Abnormality of midbrain morphology (HP:0002418)2.60520641
61Arterial tortuosity (HP:0005116)2.54055535
62Loss of speech (HP:0002371)2.52709424
63Cerebral inclusion bodies (HP:0100314)2.51683207
64Hyperventilation (HP:0002883)2.51663581
65Orchitis (HP:0100796)2.50020756
66Medial flaring of the eyebrow (HP:0010747)2.48320161
67Hemiplegia (HP:0002301)2.47762629
68Retinal atrophy (HP:0001105)2.47582838
69Bronchiectasis (HP:0002110)2.46864750
70Myositis (HP:0100614)2.45293366
71Abnormality of renin-angiotensin system (HP:0000847)2.44542923
72Supranuclear gaze palsy (HP:0000605)2.41356680
73Gait imbalance (HP:0002141)2.39493065
74Neuronal loss in central nervous system (HP:0002529)2.38296643
75Tubular atrophy (HP:0000092)2.35584718
76Genetic anticipation (HP:0003743)2.35443048
77Inappropriate behavior (HP:0000719)2.33107507
78Recurrent bacterial skin infections (HP:0005406)2.30835816
79Abnormality of the renal medulla (HP:0100957)2.30551738
80Nasal polyposis (HP:0100582)2.28860446
81Metaphyseal cupping (HP:0003021)2.28106067
82Occipital encephalocele (HP:0002085)2.27403605
83Hypercalciuria (HP:0002150)2.24845198
84Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.24627819
85Vascular tortuosity (HP:0004948)2.23869200
86Cervical subluxation (HP:0003308)2.23866663
87Congenital primary aphakia (HP:0007707)2.23769839
88Cerebral aneurysm (HP:0004944)2.21764718
89J-shaped sella turcica (HP:0002680)2.21239384
90Abnormality of the nasal mucosa (HP:0000433)2.21231309
91Renal salt wasting (HP:0000127)2.21146390
92Hyperaldosteronism (HP:0000859)2.20142565
93Progressive cerebellar ataxia (HP:0002073)2.19546801
94Abnormality of proline metabolism (HP:0010907)2.18186616
95Hydroxyprolinuria (HP:0003080)2.18186616
96Eczematoid dermatitis (HP:0000976)2.18122968
97Decreased circulating renin level (HP:0003351)2.16232003
98Recurrent gram-negative bacterial infections (HP:0005420)2.14749719
99Nephrogenic diabetes insipidus (HP:0009806)2.12888827
100Mesangial abnormality (HP:0001966)2.12381697
101Ovoid vertebral bodies (HP:0003300)2.11428725
102Global brain atrophy (HP:0002283)2.10964971
103Hip dysplasia (HP:0001385)2.10707193
104Diplopia (HP:0000651)2.08805276
105Abnormality of binocular vision (HP:0011514)2.08805276
106Genital tract atresia (HP:0001827)2.08795067
107Amyloidosis (HP:0011034)2.06261879
108Absent speech (HP:0001344)2.05058870
109Vaginal atresia (HP:0000148)2.03936335
110Abolished electroretinogram (ERG) (HP:0000550)2.03853570
111* Increased CSF protein (HP:0002922)2.03283232
112Congenital hepatic fibrosis (HP:0002612)2.02549710
113Abnormality of purine metabolism (HP:0004352)2.01885547
114Hypophosphatemia (HP:0002148)2.00966999
115Hematochezia (HP:0002573)2.00067371
116Pathologic fracture (HP:0002756)1.98697675
117Amyotrophic lateral sclerosis (HP:0007354)1.97856291
118Persistence of primary teeth (HP:0006335)1.96245532
119Chronic bronchitis (HP:0004469)1.95348100
120Hypokalemia (HP:0002900)1.95258850
121Interstitial pulmonary disease (HP:0006530)1.90473938
122Elevated erythrocyte sedimentation rate (HP:0003565)1.90292081
123* Peripheral demyelination (HP:0011096)1.89704425
124Distal upper limb amyotrophy (HP:0007149)1.89673189
125Upper limb amyotrophy (HP:0009129)1.89673189
126Tubulointerstitial abnormality (HP:0001969)1.87945823
127Lymphangioma (HP:0100764)1.85916291
128Stage 5 chronic kidney disease (HP:0003774)1.85201663
129Progressive visual loss (HP:0000529)1.85129456
130Tubulointerstitial fibrosis (HP:0005576)1.84197258
131Hand muscle atrophy (HP:0009130)1.83454844
132Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.82599387
133Degeneration of the lateral corticospinal tracts (HP:0002314)1.82599387
134Abnormality of glutamine family amino acid metabolism (HP:0010902)1.82456901
135Recurrent sinusitis (HP:0011108)1.81561493
136Drooling (HP:0002307)1.81361356
137Cystic liver disease (HP:0006706)1.80943836
138Spondylolisthesis (HP:0003302)1.80629163
139Alkalosis (HP:0001948)1.80537857
140Abnormality of potassium homeostasis (HP:0011042)1.80140529
141Excessive salivation (HP:0003781)1.80027588
142Increased purine levels (HP:0004368)1.78084344
143Hyperuricemia (HP:0002149)1.78084344
144Male pseudohermaphroditism (HP:0000037)1.77030949
145Action tremor (HP:0002345)1.75871276
146Obstructive lung disease (HP:0006536)1.72853371
147Chronic obstructive pulmonary disease (HP:0006510)1.72853371
148Turricephaly (HP:0000262)1.72754711
149Infertility (HP:0000789)1.72572998
150Aplasia/Hypoplasia of the tibia (HP:0005772)1.72561940
151Apathy (HP:0000741)1.71670134
152Abnormality of the lumbar spine (HP:0100712)1.71275373
153Thoracic kyphosis (HP:0002942)1.71263774
154Metaphyseal dysplasia (HP:0100255)1.71112682
155Myocardial infarction (HP:0001658)1.70916849
156Widely spaced teeth (HP:0000687)1.69517273
157Diminished motivation (HP:0000745)1.69353630
158Abnormality of the periventricular white matter (HP:0002518)1.67842506
159Protuberant abdomen (HP:0001538)1.67506184
160Febrile seizures (HP:0002373)1.67266490
161Osteolytic defects of the phalanges of the hand (HP:0009771)1.67105043
162Osteolytic defects of the hand bones (HP:0009699)1.67105043
163Nephropathy (HP:0000112)1.66675998
164Failure to thrive in infancy (HP:0001531)1.66085358
165Hypoplasia of the odontoid process (HP:0003311)1.64221982
166Rapidly progressive (HP:0003678)1.63578139
167Femoral bowing (HP:0002980)1.61669056

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.18764323
2FRK3.38199701
3TRIB33.26069390
4OXSR12.94699811
5ACVR1B2.44215249
6WNK32.32627383
7PRKD32.31502503
8TGFBR22.25414193
9CAMK1G2.22370542
10EPHA32.17224837
11CASK2.08095145
12NTRK12.07945842
13ADRBK21.99333562
14GRK71.99057854
15RIPK41.98373598
16STK391.97097509
17CAMK1D1.96585244
18MAP3K41.94843456
19RIPK11.79722110
20MAP3K91.74830357
21MAP3K21.66526059
22EPHB11.65368569
23PKN21.60150597
24BCR1.58230175
25WNK11.50748834
26PTK61.50210254
27EPHA41.48495448
28KSR21.44303286
29BMX1.41515252
30CSNK1G21.32848147
31PTK21.30037392
32PAK41.29695232
33ERN11.29645951
34TTN1.29003083
35MAP3K131.25633739
36PDGFRA1.24546191
37SGK31.23415680
38MAPK131.23036231
39CAMKK11.19203836
40SGK4941.17213033
41SGK2231.17213033
42PAK61.16569084
43KIT1.12824053
44MARK11.12465224
45TAOK31.09784911
46LRRK21.08637754
47PRKCH1.07884014
48JAK11.04934166
49CSF1R1.04905733
50TBK11.04016077
51MET1.03990248
52PTK2B1.00006235
53NEK90.99995695
54PDPK10.98529513
55TRIM280.96241947
56PDGFRB0.95936677
57SCYL20.95540155
58YES10.95522625
59PDK40.95283932
60PDK30.95283932
61JAK20.94519081
62STK380.92842918
63IRAK30.91418879
64EPHB20.91257196
65TNIK0.90848322
66MAP2K40.90831022
67MAP2K70.90208816
68STK100.89305755
69FER0.88615384
70SGK20.88449132
71FGR0.88377895
72PIK3CG0.88287765
73TXK0.87079027
74PIK3CA0.86682249
75MAPK70.86665777
76IKBKE0.85841332
77GSK3A0.85439852
78PDK10.85285493
79RET0.85193186
80INSRR0.83880509
81CAMKK20.83724057
82PDK20.83539633
83DMPK0.81975783
84NTRK20.81971962
85IRAK20.81812966
86PINK10.80915158
87TYK20.80905094
88DAPK20.80733284
89EGFR0.80382571
90MAP3K140.79232906
91TESK10.78939990
92NTRK30.77949342
93SYK0.77542554
94DYRK1A0.75869656
95KSR10.75679521
96TNK20.74952563
97MST1R0.74933752
98FES0.74702787
99CSNK1G30.74678598
100LYN0.74523351
101CSNK1A1L0.73654574
102PNCK0.72149371
103MAP3K10.72116768
104HCK0.71165504
105BMPR20.70166200
106GRK10.69693279
107DYRK20.68865902
108MAPK150.67742220
109MAP3K60.67620817
110MOS0.67211551
111LCK0.65954184
112STK110.65739595
113ZAP700.65598174
114TEC0.64937851
115ADRBK10.63177694
116SGK10.62790993
117CDK50.62648158
118FYN0.62417689
119IKBKB0.62404420
120TRPM70.62346938
121IRAK10.62179113
122CDK60.61770097
123CAMK2A0.61333205
124MAP3K30.60716735
125TYRO30.59930323
126DYRK1B0.59869595
127IRAK40.59427830
128CSNK1G10.59150649
129MAP2K30.58974896
130PLK20.58902283
131BMPR1B0.58352277
132PRKCG0.58229112
133TIE10.56489395
134BLK0.56425025
135PAK30.55860812
136DYRK30.55604433
137TAOK10.55012180
138PRKCZ0.54964462
139CSK0.54591286
140MAP3K110.53958563
141PAK20.53465168
142BTK0.52767748
143ERBB20.51569080
144IGF1R0.51188226
145SRC0.51067600
146MARK20.50209710
147ICK0.48586718
148ITK0.48276440
149MARK30.44999956
150INSR0.44881618
151ERBB30.43449433
152MATK0.42473240
153PRKCE0.42450824
154ABL20.39837680
155SIK20.38647572
156ABL10.37872083

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.29836047
2* Lysosome_Homo sapiens_hsa041423.01580991
3Other glycan degradation_Homo sapiens_hsa005112.18393373
4Collecting duct acid secretion_Homo sapiens_hsa049661.96163144
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84444097
6Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65952829
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65863981
8Nicotine addiction_Homo sapiens_hsa050331.58594127
9Phagosome_Homo sapiens_hsa041451.49748582
10Staphylococcus aureus infection_Homo sapiens_hsa051501.45840703
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.44917207
12Ovarian steroidogenesis_Homo sapiens_hsa049131.35200987
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32401410
14Leishmaniasis_Homo sapiens_hsa051401.29620361
15Osteoclast differentiation_Homo sapiens_hsa043801.28033241
16Tuberculosis_Homo sapiens_hsa051521.27236307
17Ether lipid metabolism_Homo sapiens_hsa005651.26391934
18Dorso-ventral axis formation_Homo sapiens_hsa043201.26017691
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25257099
20Morphine addiction_Homo sapiens_hsa050321.24668291
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.22342160
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22012218
23Mineral absorption_Homo sapiens_hsa049781.19050080
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18637989
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17836742
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17798660
27Rheumatoid arthritis_Homo sapiens_hsa053231.15510144
28Phototransduction_Homo sapiens_hsa047441.13916615
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10779838
30Amoebiasis_Homo sapiens_hsa051461.09355727
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07617302
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06625643
33Synaptic vesicle cycle_Homo sapiens_hsa047211.05873785
34Glutamatergic synapse_Homo sapiens_hsa047241.05040017
35Histidine metabolism_Homo sapiens_hsa003401.04812993
36Asthma_Homo sapiens_hsa053101.04446472
37GABAergic synapse_Homo sapiens_hsa047271.03560379
38Circadian entrainment_Homo sapiens_hsa047131.01806959
39Focal adhesion_Homo sapiens_hsa045101.00027189
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99989857
41Pertussis_Homo sapiens_hsa051330.99177563
42Gastric acid secretion_Homo sapiens_hsa049710.98919205
43ECM-receptor interaction_Homo sapiens_hsa045120.98211024
44Linoleic acid metabolism_Homo sapiens_hsa005910.97973329
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96807192
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96280800
47Proteoglycans in cancer_Homo sapiens_hsa052050.94911166
48ABC transporters_Homo sapiens_hsa020100.94313030
49Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93994180
50Cocaine addiction_Homo sapiens_hsa050300.93630459
51Endocytosis_Homo sapiens_hsa041440.93057744
52Glioma_Homo sapiens_hsa052140.92802291
53Chronic myeloid leukemia_Homo sapiens_hsa052200.92705089
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92311377
55Bile secretion_Homo sapiens_hsa049760.91333868
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90196942
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89863206
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.89773085
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88585270
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88296869
61Pancreatic cancer_Homo sapiens_hsa052120.87685614
62Nitrogen metabolism_Homo sapiens_hsa009100.87108567
63Butanoate metabolism_Homo sapiens_hsa006500.86630810
64Long-term depression_Homo sapiens_hsa047300.86165423
65Renal cell carcinoma_Homo sapiens_hsa052110.85217199
66Graft-versus-host disease_Homo sapiens_hsa053320.83762832
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83576167
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82658195
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.81526552
70Serotonergic synapse_Homo sapiens_hsa047260.80069033
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.79817301
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79529666
73Legionellosis_Homo sapiens_hsa051340.78905544
74Type II diabetes mellitus_Homo sapiens_hsa049300.78721922
75Vibrio cholerae infection_Homo sapiens_hsa051100.78086570
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78078329
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77453364
78Thyroid hormone synthesis_Homo sapiens_hsa049180.75275688
79Dopaminergic synapse_Homo sapiens_hsa047280.75208632
80Protein digestion and absorption_Homo sapiens_hsa049740.74287801
81Insulin secretion_Homo sapiens_hsa049110.74285315
82Toxoplasmosis_Homo sapiens_hsa051450.74189108
83Cholinergic synapse_Homo sapiens_hsa047250.73883507
84Malaria_Homo sapiens_hsa051440.73844268
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73144769
86Allograft rejection_Homo sapiens_hsa053300.73083720
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72705657
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.69609271
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.69584522
90Salmonella infection_Homo sapiens_hsa051320.69477556
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.68500057
92Hematopoietic cell lineage_Homo sapiens_hsa046400.67358764
93Platelet activation_Homo sapiens_hsa046110.66527882
94mTOR signaling pathway_Homo sapiens_hsa041500.65918814
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.65627219
96Renin secretion_Homo sapiens_hsa049240.65329652
97B cell receptor signaling pathway_Homo sapiens_hsa046620.65077826
98Sulfur metabolism_Homo sapiens_hsa009200.64485233
99Renin-angiotensin system_Homo sapiens_hsa046140.64398676
100Shigellosis_Homo sapiens_hsa051310.63748195
101PPAR signaling pathway_Homo sapiens_hsa033200.63541295
102* Sphingolipid metabolism_Homo sapiens_hsa006000.63175378
103Caffeine metabolism_Homo sapiens_hsa002320.62993632
104Chemical carcinogenesis_Homo sapiens_hsa052040.62906715
105African trypanosomiasis_Homo sapiens_hsa051430.61325118
106Taste transduction_Homo sapiens_hsa047420.61172023
107Antigen processing and presentation_Homo sapiens_hsa046120.60333489
108Small cell lung cancer_Homo sapiens_hsa052220.59316501
109Inositol phosphate metabolism_Homo sapiens_hsa005620.59237451
110Regulation of autophagy_Homo sapiens_hsa041400.58850223
111Tryptophan metabolism_Homo sapiens_hsa003800.58516712
112Type I diabetes mellitus_Homo sapiens_hsa049400.58263804
113VEGF signaling pathway_Homo sapiens_hsa043700.57961415
114Ras signaling pathway_Homo sapiens_hsa040140.57688984
115Olfactory transduction_Homo sapiens_hsa047400.57628101
116Oxytocin signaling pathway_Homo sapiens_hsa049210.57471469
117Chemokine signaling pathway_Homo sapiens_hsa040620.57402775
118Arachidonic acid metabolism_Homo sapiens_hsa005900.57161940
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56871984
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56684538
121Insulin resistance_Homo sapiens_hsa049310.56183198
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.55150704
123Autoimmune thyroid disease_Homo sapiens_hsa053200.55129737
124Lysine degradation_Homo sapiens_hsa003100.54991474
125Rap1 signaling pathway_Homo sapiens_hsa040150.54931361
126Estrogen signaling pathway_Homo sapiens_hsa049150.54445451
127Adherens junction_Homo sapiens_hsa045200.54402230
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54211247
129Steroid biosynthesis_Homo sapiens_hsa001000.53726469
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52783988
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.52669263
132Amphetamine addiction_Homo sapiens_hsa050310.51599184
133Choline metabolism in cancer_Homo sapiens_hsa052310.51538268
134ErbB signaling pathway_Homo sapiens_hsa040120.49332091
135Prolactin signaling pathway_Homo sapiens_hsa049170.48663300
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48574767
137Salivary secretion_Homo sapiens_hsa049700.47266627
138Fatty acid metabolism_Homo sapiens_hsa012120.45883008
139Non-small cell lung cancer_Homo sapiens_hsa052230.45867293
140Prion diseases_Homo sapiens_hsa050200.44586458
141Bladder cancer_Homo sapiens_hsa052190.43716824
142Glycerolipid metabolism_Homo sapiens_hsa005610.43558618
143Dilated cardiomyopathy_Homo sapiens_hsa054140.42682908
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41861793
145Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41799332
146Fatty acid degradation_Homo sapiens_hsa000710.40811563
147Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40777847
148TNF signaling pathway_Homo sapiens_hsa046680.40191077
149Endometrial cancer_Homo sapiens_hsa052130.39426762
150Axon guidance_Homo sapiens_hsa043600.39253928
151cAMP signaling pathway_Homo sapiens_hsa040240.38583715
152Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38285178
153Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38276009
154Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37694510

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »