GALK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Galactokinase is a major enzyme for the metabolism of galactose and its deficiency causes congenital cataracts during infancy and presenile cataracts in the adult population. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.76541628
2nucleobase biosynthetic process (GO:0046112)4.71409872
3purine nucleobase biosynthetic process (GO:0009113)4.61622247
4maturation of SSU-rRNA (GO:0030490)4.50803287
5DNA deamination (GO:0045006)4.50281985
6formation of translation preinitiation complex (GO:0001731)4.43447265
7viral transcription (GO:0019083)4.41544978
8GDP-mannose metabolic process (GO:0019673)4.34617018
9translational termination (GO:0006415)4.33582315
10folic acid metabolic process (GO:0046655)4.30068229
11DNA strand elongation involved in DNA replication (GO:0006271)4.28762917
12folic acid-containing compound biosynthetic process (GO:0009396)4.26998348
13protein maturation by protein folding (GO:0022417)4.25988040
14ribosomal small subunit biogenesis (GO:0042274)4.14500514
15DNA strand elongation (GO:0022616)4.05812098
16glycine metabolic process (GO:0006544)4.04615147
17translational elongation (GO:0006414)4.02370837
18ribosome assembly (GO:0042255)4.00927146
19DNA replication initiation (GO:0006270)3.92853781
20regulation of cholesterol esterification (GO:0010872)3.92624599
21translational initiation (GO:0006413)3.91753909
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.91685795
23L-phenylalanine metabolic process (GO:0006558)3.91685795
24DNA unwinding involved in DNA replication (GO:0006268)3.90809232
25telomere maintenance via semi-conservative replication (GO:0032201)3.90572821
26ribosomal large subunit biogenesis (GO:0042273)3.90037332
27L-serine metabolic process (GO:0006563)3.76191516
28proline biosynthetic process (GO:0006561)3.72448728
29serine family amino acid biosynthetic process (GO:0009070)3.71056512
30ribonucleoprotein complex biogenesis (GO:0022613)3.70525026
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.66505234
32ribosome biogenesis (GO:0042254)3.58123623
33phospholipid efflux (GO:0033700)3.56088145
34proteasome assembly (GO:0043248)3.55599141
35protein targeting to ER (GO:0045047)3.55362268
36cotranslational protein targeting to membrane (GO:0006613)3.54525041
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.54161420
38negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.52123062
39pentose metabolic process (GO:0019321)3.49507544
40regulation of mitochondrial translation (GO:0070129)3.46311007
41pinocytosis (GO:0006907)3.43075565
42proline metabolic process (GO:0006560)3.42254256
43IMP biosynthetic process (GO:0006188)3.41259830
44protein localization to kinetochore (GO:0034501)3.41120487
45L-phenylalanine catabolic process (GO:0006559)3.41078943
46erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.41078943
47pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.38769885
48protein localization to endoplasmic reticulum (GO:0070972)3.37354079
49positive regulation of triglyceride lipase activity (GO:0061365)3.37319167
50positive regulation of lipoprotein lipase activity (GO:0051006)3.37319167
51establishment of protein localization to endoplasmic reticulum (GO:0072599)3.35612049
52cellular protein complex disassembly (GO:0043624)3.34415883
53viral life cycle (GO:0019058)3.33165572
54telomere maintenance via recombination (GO:0000722)3.32797501
55DNA replication checkpoint (GO:0000076)3.31811423
56peptidyl-glutamic acid carboxylation (GO:0017187)3.23430785
57protein carboxylation (GO:0018214)3.23430785
58mitotic nuclear envelope disassembly (GO:0007077)3.21277773
59rRNA processing (GO:0006364)3.19806187
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17656458
61mitotic metaphase plate congression (GO:0007080)3.16597312
62folic acid-containing compound metabolic process (GO:0006760)3.13183583
63translation (GO:0006412)3.12615550
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12602368
65pteridine-containing compound biosynthetic process (GO:0042559)3.12261934
66tetrahydrofolate metabolic process (GO:0046653)3.11571170
67telomere maintenance via telomere lengthening (GO:0010833)3.11096987
68DNA replication-dependent nucleosome organization (GO:0034723)3.10101496
69DNA replication-dependent nucleosome assembly (GO:0006335)3.10101496
70mitotic recombination (GO:0006312)3.10000152
71peptidyl-arginine omega-N-methylation (GO:0035247)3.09855551
72pseudouridine synthesis (GO:0001522)3.08314647
73regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.07617389
74rRNA metabolic process (GO:0016072)3.07487577
75spliceosomal snRNP assembly (GO:0000387)3.07299784
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06664915
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.06365999
78guanosine-containing compound biosynthetic process (GO:1901070)3.04113867
79protein complex disassembly (GO:0043241)3.02083365
80IMP metabolic process (GO:0046040)3.01864646
81serine family amino acid metabolic process (GO:0009069)3.00101785
82regulation of lipoprotein particle clearance (GO:0010984)2.98470283
83deoxyribonucleotide catabolic process (GO:0009264)2.95916367
84pentose-phosphate shunt (GO:0006098)2.92004620
85nuclear envelope disassembly (GO:0051081)2.91992359
86membrane disassembly (GO:0030397)2.91992359
87deoxyribose phosphate catabolic process (GO:0046386)2.90580642
88negative regulation of ligase activity (GO:0051352)2.90524901
89negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90524901
90L-methionine biosynthetic process (GO:0071265)2.90182875
91amino acid salvage (GO:0043102)2.90182875
92L-methionine salvage (GO:0071267)2.90182875
93negative regulation of fibrinolysis (GO:0051918)2.89383591
94base-excision repair, AP site formation (GO:0006285)2.89106730
95iron-sulfur cluster assembly (GO:0016226)2.86550471
96metallo-sulfur cluster assembly (GO:0031163)2.86550471
97purine deoxyribonucleotide catabolic process (GO:0009155)2.85471339
98macromolecular complex disassembly (GO:0032984)2.85401504
99protein localization to chromosome, centromeric region (GO:0071459)2.84164401
100nucleotide-excision repair, DNA gap filling (GO:0006297)2.82356707
101nucleoside salvage (GO:0043174)2.81811114
102pteridine-containing compound metabolic process (GO:0042558)2.76126749
103nuclear-transcribed mRNA catabolic process (GO:0000956)2.74021668
104pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.73165931
105plasma lipoprotein particle assembly (GO:0034377)2.73112344
106L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72429283
107urea metabolic process (GO:0019627)2.72035455
108cellular component biogenesis (GO:0044085)2.72018458
109very-low-density lipoprotein particle assembly (GO:0034379)2.71828728
110positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.71596143
111rRNA modification (GO:0000154)2.71268074
112CENP-A containing nucleosome assembly (GO:0034080)2.71245149
113urea cycle (GO:0000050)2.68819300
114pyrimidine nucleotide catabolic process (GO:0006244)2.68778050
115chromatin remodeling at centromere (GO:0031055)2.68672630
116regulation of fibrinolysis (GO:0051917)2.68153647
117pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.67859303
118positive regulation of fatty acid biosynthetic process (GO:0045723)2.67451878
119negative regulation of B cell apoptotic process (GO:0002903)2.67202816
120COPI coating of Golgi vesicle (GO:0048205)2.67030718
121Golgi transport vesicle coating (GO:0048200)2.67030718
122cell cycle G1/S phase transition (GO:0044843)2.66956927
123G1/S transition of mitotic cell cycle (GO:0000082)2.66956927
1244-hydroxyproline metabolic process (GO:0019471)2.66790268
125regulation of cellular amino acid metabolic process (GO:0006521)2.66716041
126negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.66514386
127nitrogen cycle metabolic process (GO:0071941)2.66324679
128regulation of mammary gland epithelial cell proliferation (GO:0033599)2.66244273
129triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.66236949
130deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.65790893
131sulfur amino acid biosynthetic process (GO:0000097)2.65646691
132DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.65018949
133regulation of translational termination (GO:0006449)2.64606655
134UTP biosynthetic process (GO:0006228)2.64322784
135regulation of spindle organization (GO:0090224)2.63819732
136signal transduction involved in DNA integrity checkpoint (GO:0072401)2.63303320
137signal transduction involved in DNA damage checkpoint (GO:0072422)2.63303320
138signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.61554935
139signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.61554935
140signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.61554935
141negative regulation of sterol transport (GO:0032372)2.61429534
142negative regulation of cholesterol transport (GO:0032375)2.61429534
143signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.61289372
144intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.61289372
145methionine biosynthetic process (GO:0009086)2.61282062
146pyrimidine-containing compound salvage (GO:0008655)2.61192372
147pyrimidine nucleoside salvage (GO:0043097)2.61192372
148transcription-coupled nucleotide-excision repair (GO:0006283)2.61185259
149negative regulation of myeloid cell apoptotic process (GO:0033033)2.60383959
150glucose catabolic process (GO:0006007)2.60139193
151NIK/NF-kappaB signaling (GO:0038061)2.60118904
152glyoxylate metabolic process (GO:0046487)2.60050613
153histone arginine methylation (GO:0034969)2.59919579
154folic acid transport (GO:0015884)2.59570661
155chaperone-mediated protein complex assembly (GO:0051131)2.58803093
156RNA catabolic process (GO:0006401)2.58260134
157pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.56376228
158NADPH regeneration (GO:0006740)2.54770508
159deoxyribose phosphate biosynthetic process (GO:0046385)2.53032593
1602-deoxyribonucleotide biosynthetic process (GO:0009265)2.53032593
161high-density lipoprotein particle remodeling (GO:0034375)2.52975018
162UV protection (GO:0009650)2.52762006
163pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.52667895
164GTP biosynthetic process (GO:0006183)2.51846222
165protein retention in ER lumen (GO:0006621)2.49328121
166nucleobase-containing small molecule interconversion (GO:0015949)2.47642591
167cholesterol efflux (GO:0033344)2.47620078
168sulfur amino acid catabolic process (GO:0000098)2.46107899
169protein-lipid complex assembly (GO:0065005)2.45688989
170amyloid precursor protein catabolic process (GO:0042987)2.45569218
171oxidative phosphorylation (GO:0006119)2.43231857
172purine ribonucleotide transport (GO:0015868)2.42297032
173glutamine family amino acid biosynthetic process (GO:0009084)2.42203159
174rRNA transcription (GO:0009303)2.40797648
175nucleotide salvage (GO:0043173)2.40755717
176UTP metabolic process (GO:0046051)2.39375243
177regulation of triglyceride catabolic process (GO:0010896)2.38548128
178negative regulation of DNA-templated transcription, elongation (GO:0032785)2.38516316
179fibrinolysis (GO:0042730)2.38445427
180pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.37914020
181GMP metabolic process (GO:0046037)2.36440077
182regulation of superoxide anion generation (GO:0032928)2.34396898
183protein-lipid complex remodeling (GO:0034368)2.34169112
184macromolecular complex remodeling (GO:0034367)2.34169112
185plasma lipoprotein particle remodeling (GO:0034369)2.34169112
186peptidyl-arginine N-methylation (GO:0035246)2.32955107
187peptidyl-arginine methylation (GO:0018216)2.32955107
188monosaccharide biosynthetic process (GO:0046364)2.32713642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.25888488
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.16079072
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.04917679
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.94931492
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91105184
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86172642
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.72052445
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.71464824
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69989408
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69456527
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.63394301
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.59509933
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.52551910
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51797222
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47522034
16XRN2_22483619_ChIP-Seq_HELA_Human2.29645289
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27829433
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19163541
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.14514012
20LXR_22292898_ChIP-Seq_THP-1_Human2.05045965
21* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03457058
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99894110
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93262109
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90451623
25VDR_23849224_ChIP-Seq_CD4+_Human1.90110300
26AR_21909140_ChIP-Seq_LNCAP_Human1.89001366
27DCP1A_22483619_ChIP-Seq_HELA_Human1.83402846
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83170848
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80771029
30GABP_19822575_ChIP-Seq_HepG2_Human1.80580362
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.73550732
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72098505
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.72025357
34FOXP3_21729870_ChIP-Seq_TREG_Human1.72013089
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68107865
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67228470
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66851603
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.61403431
39TTF2_22483619_ChIP-Seq_HELA_Human1.59037914
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.57679561
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57599968
42* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57492527
43* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57461198
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56920726
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56574483
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56361774
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54138776
48* MYC_22102868_ChIP-Seq_BL_Human1.53746271
49* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53263929
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.51240913
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47985665
52* P68_20966046_ChIP-Seq_HELA_Human1.47728423
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.47580704
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47416652
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45893086
56* BCL6_27268052_Chip-Seq_Bcells_Human1.44989028
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.43967760
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42417962
59RACK7_27058665_Chip-Seq_MCF-7_Human1.42130361
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.41159424
61KDM5A_27292631_Chip-Seq_BREAST_Human1.39544995
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37987595
63CIITA_25753668_ChIP-Seq_RAJI_Human1.37863220
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.37838676
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35621936
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34365554
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34236308
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.33197750
69CTCF_18555785_ChIP-Seq_MESCs_Mouse1.30857240
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.28802255
71CTCF_26484167_Chip-Seq_Bcells_Mouse1.28321645
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28088229
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28058033
74* BCOR_27268052_Chip-Seq_Bcells_Human1.27890865
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.27218241
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24413263
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23919738
78* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23188910
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23014822
80VDR_24763502_ChIP-Seq_THP-1_Human1.22601373
81ZNF263_19887448_ChIP-Seq_K562_Human1.21510501
82RXR_22158963_ChIP-Seq_LIVER_Mouse1.21298372
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20762288
84* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20155128
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19803358
86VDR_21846776_ChIP-Seq_THP-1_Human1.19236263
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18867603
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18860636
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18326320
90MAF_26560356_Chip-Seq_TH2_Human1.18282151
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18256487
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.17806958
93MAF_26560356_Chip-Seq_TH1_Human1.17690971
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16922610
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16694775
96HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15194059
97ELK1_19687146_ChIP-ChIP_HELA_Human1.11924306
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11473366
99UTX_26944678_Chip-Seq_JUKART_Human1.10308717
100ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09932851
101CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09763015
102CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09713854
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09281616
104* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09111940
105FOXP1_21924763_ChIP-Seq_HESCs_Human1.08901622
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08779109
107TFEB_21752829_ChIP-Seq_HELA_Human1.08058507
108POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07643345
109STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07419420
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06000575
111* CTCF_21964334_Chip-Seq_Bcells_Human1.05985442
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05170300
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04989051
114PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03977356
115* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02898045
116RARA_24833708_ChIP-Seq_LIVER_Mouse1.02396507
117ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01964475
118OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01850974
119* SPI1_23547873_ChIP-Seq_NB4_Human1.01790025
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01488894
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01283406
122E2F1_20622854_ChIP-Seq_HELA_Human1.01129672
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00418399
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97702303
125SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96958631
126TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96797740
127SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96439349
128ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94864900
129* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93233986
130SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92165020
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91870713
132KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91350687
133EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89159999
134CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88958231
135NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88515577
136ELK1_22589737_ChIP-Seq_MCF10A_Human0.85525213
137ATF3_27146783_Chip-Seq_COLON_Human0.83470710
138TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81958028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.62055497
2MP0004957_abnormal_blastocyst_morpholog3.76711830
3MP0005058_abnormal_lysosome_morphology3.64211661
4MP0003111_abnormal_nucleus_morphology3.51329576
5MP0003806_abnormal_nucleotide_metabolis3.25765525
6MP0009840_abnormal_foam_cell3.10664474
7MP0010094_abnormal_chromosome_stability3.04523169
8MP0008260_abnormal_autophagy3.04271824
9MP0003077_abnormal_cell_cycle2.99931200
10MP0002877_abnormal_melanocyte_morpholog2.71652899
11MP0002139_abnormal_hepatobiliary_system2.50834140
12MP0005360_urolithiasis2.32086604
13MP0010352_gastrointestinal_tract_polyps2.16496637
14MP0008932_abnormal_embryonic_tissue2.11020848
15MP0003123_paternal_imprinting2.10291237
16MP0001730_embryonic_growth_arrest2.09975451
17MP0003436_decreased_susceptibility_to2.07929341
18MP0008057_abnormal_DNA_replication2.07524383
19MP0003705_abnormal_hypodermis_morpholog2.00864127
20MP0008058_abnormal_DNA_repair1.98302262
21MP0009278_abnormal_bone_marrow1.96303413
22MP0008007_abnormal_cellular_replicative1.93530758
23MP0005365_abnormal_bile_salt1.91846029
24MP0005464_abnormal_platelet_physiology1.79879419
25MP0005085_abnormal_gallbladder_physiolo1.77899750
26MP0002396_abnormal_hematopoietic_system1.77214641
27MP0001835_abnormal_antigen_presentation1.76480434
28MP0003718_maternal_effect1.71911751
29MP0003567_abnormal_fetal_cardiomyocyte1.68804969
30MP0003186_abnormal_redox_activity1.65564902
31MP0005025_abnormal_response_to1.64676350
32MP0000350_abnormal_cell_proliferation1.64632603
33MP0001672_abnormal_embryogenesis/_devel1.55650893
34MP0005380_embryogenesis_phenotype1.55650893
35MP0002138_abnormal_hepatobiliary_system1.54971211
36MP0002419_abnormal_innate_immunity1.53077854
37MP0001697_abnormal_embryo_size1.52059868
38MP0003172_abnormal_lysosome_physiology1.49124489
39MP0000490_abnormal_crypts_of1.49048745
40MP0000685_abnormal_immune_system1.48718711
41MP0003303_peritoneal_inflammation1.47308500
42MP0002080_prenatal_lethality1.45789421
43MP0003984_embryonic_growth_retardation1.45023073
44MP0002088_abnormal_embryonic_growth/wei1.43889466
45MP0000372_irregular_coat_pigmentation1.40285536
46MP0003786_premature_aging1.39576056
47MP0005083_abnormal_biliary_tract1.36979463
48MP0010030_abnormal_orbit_morphology1.33646689
49MP0002086_abnormal_extraembryonic_tissu1.33265979
50MP0002148_abnormal_hypersensitivity_rea1.31640589
51MP0008469_abnormal_protein_level1.31272640
52MP0010307_abnormal_tumor_latency1.30522023
53MP0009785_altered_susceptibility_to1.29385613
54MP0002723_abnormal_immune_serum1.27874137
55MP0009333_abnormal_splenocyte_physiolog1.27658126
56MP0000678_abnormal_parathyroid_gland1.26780993
57MP0004197_abnormal_fetal_growth/weight/1.26345383
58MP0004858_abnormal_nervous_system1.25963475
59MP0005023_abnormal_wound_healing1.25897745
60MP0005000_abnormal_immune_tolerance1.25347579
61MP0005332_abnormal_amino_acid1.25097021
62MP0005671_abnormal_response_to1.22868847
63MP0009053_abnormal_anal_canal1.21720530
64MP0001800_abnormal_humoral_immune1.21295183
65MP0002019_abnormal_tumor_incidence1.20122079
66MP0002452_abnormal_antigen_presenting1.18645767
67MP0001819_abnormal_immune_cell1.18295532
68MP0002420_abnormal_adaptive_immunity1.17823602
69MP0002085_abnormal_embryonic_tissue1.17302488
70MP0000313_abnormal_cell_death1.15613155
71MP0003195_calcinosis1.15600275
72MP0000015_abnormal_ear_pigmentation1.15283802
73MP0000358_abnormal_cell_content/1.13653637
74MP0010329_abnormal_lipoprotein_level1.13544652
75MP0004381_abnormal_hair_follicle1.12001112
76MP0000598_abnormal_liver_morphology1.10890214
77MP0005451_abnormal_body_composition1.10333124
78MP0002084_abnormal_developmental_patter1.09607482
79MP0003075_altered_response_to1.08549018
80MP0008875_abnormal_xenobiotic_pharmacok1.07036710
81MP0000537_abnormal_urethra_morphology1.05484629
82MP0000716_abnormal_immune_system1.04557409
83MP0003763_abnormal_thymus_physiology1.04509360
84MP0001666_abnormal_nutrient_absorption1.04383645
85MP0005387_immune_system_phenotype1.03912552
86MP0001790_abnormal_immune_system1.03912552
87MP0003191_abnormal_cellular_cholesterol1.03639098
88MP0001845_abnormal_inflammatory_respons1.01704348
89MP0004019_abnormal_vitamin_homeostasis1.01560743
90MP0000681_abnormal_thyroid_gland0.99829662
91MP0000343_altered_response_to0.98734326
92MP0009672_abnormal_birth_weight0.97925348
93MP0003119_abnormal_digestive_system0.97839076
94MP0000609_abnormal_liver_physiology0.97838014
95MP0005319_abnormal_enzyme/_coenzyme0.97623784
96MP0002132_abnormal_respiratory_system0.97512180
97MP0004808_abnormal_hematopoietic_stem0.97172181
98MP0001661_extended_life_span0.95505400
99MP0005397_hematopoietic_system_phenotyp0.95348274
100MP0001545_abnormal_hematopoietic_system0.95348274
101MP0004185_abnormal_adipocyte_glucose0.94089731
102MP0003315_abnormal_perineum_morphology0.93274516
103MP0001293_anophthalmia0.91968382
104MP0006082_CNS_inflammation0.90041111
105MP0004264_abnormal_extraembryonic_tissu0.89774186
106MP0001915_intracranial_hemorrhage0.89190109
107MP0006036_abnormal_mitochondrial_physio0.88875173
108MP0003221_abnormal_cardiomyocyte_apopto0.88671943
109MP0001533_abnormal_skeleton_physiology0.88357811
110MP0003566_abnormal_cell_adhesion0.87584062
111MP0005501_abnormal_skin_physiology0.86409583
112MP0005330_cardiomyopathy0.86036579
113MP0006054_spinal_hemorrhage0.85479707
114MP0009764_decreased_sensitivity_to0.84809294
115MP0005075_abnormal_melanosome_morpholog0.84658016
116MP0002249_abnormal_larynx_morphology0.83755770
117MP0006035_abnormal_mitochondrial_morpho0.83001982
118MP0002722_abnormal_immune_system0.82010558
119MP0005670_abnormal_white_adipose0.81847120
120MP0010155_abnormal_intestine_physiology0.80705003
121MP0002111_abnormal_tail_morphology0.80484160
122MP0005584_abnormal_enzyme/coenzyme_acti0.80341532
123MP0005171_absent_coat_pigmentation0.80296437
124MP0000858_altered_metastatic_potential0.80122973
125MP0002405_respiratory_system_inflammati0.79808681
126MP0000689_abnormal_spleen_morphology0.78941100
127MP0005165_increased_susceptibility_to0.78316706
128MP0001873_stomach_inflammation0.77719722
129MP0009697_abnormal_copulation0.77009549
130MP0000477_abnormal_intestine_morphology0.75413267
131MP0009643_abnormal_urine_homeostasis0.74674395
132MP0005408_hypopigmentation0.74481282
133MP0001849_ear_inflammation0.74095547
134MP0002160_abnormal_reproductive_system0.73554667
135MP0001853_heart_inflammation0.72646568
136MP0000703_abnormal_thymus_morphology0.69309121
137* MP0001764_abnormal_homeostasis0.67728190
138MP0009379_abnormal_foot_pigmentation0.67364315
139MP0005389_reproductive_system_phenotype0.67166715
140MP0005395_other_phenotype0.66761394
141MP0001145_abnormal_male_reproductive0.66227023
142MP0002092_abnormal_eye_morphology0.64627116
143MP0005384_cellular_phenotype0.64055726
144MP0004133_heterotaxia0.63714551
145MP0005266_abnormal_metabolism0.62931780
146MP0008438_abnormal_cutaneous_collagen0.62699827
147MP0005377_hearing/vestibular/ear_phenot0.60215070
148MP0003878_abnormal_ear_physiology0.60215070
149MP0003656_abnormal_erythrocyte_physiolo0.60087379
150MP0002210_abnormal_sex_determination0.59883142
151MP0002429_abnormal_blood_cell0.59456574
152MP0000371_diluted_coat_color0.56881369
153MP0003115_abnormal_respiratory_system0.56780349
154MP0002398_abnormal_bone_marrow0.56573591

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.19675598
2Reticulocytopenia (HP:0001896)4.09552654
3Abnormal number of erythroid precursors (HP:0012131)3.96858693
4Macrocytic anemia (HP:0001972)3.62562622
5Breast hypoplasia (HP:0003187)3.54537501
6Birth length less than 3rd percentile (HP:0003561)3.39237268
7Multiple enchondromatosis (HP:0005701)3.35976637
8Oral leukoplakia (HP:0002745)3.35912889
9Abnormality of pyrimidine metabolism (HP:0004353)3.33779868
10Selective tooth agenesis (HP:0001592)3.18886675
11Hyperglycinemia (HP:0002154)3.15256890
12Megaloblastic anemia (HP:0001889)3.15146941
13Cholecystitis (HP:0001082)3.13040305
14Abnormal gallbladder physiology (HP:0012438)3.13040305
15Hypobetalipoproteinemia (HP:0003563)3.10355073
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.07272835
17Microretrognathia (HP:0000308)2.87104792
18Systemic lupus erythematosus (HP:0002725)2.86890020
19Carpal bone hypoplasia (HP:0001498)2.85400335
20Rough bone trabeculation (HP:0100670)2.83039578
21Joint hemorrhage (HP:0005261)2.82244793
22Cerebral hypomyelination (HP:0006808)2.77368131
23Abnormality of glycolipid metabolism (HP:0010969)2.75487486
24Abnormality of liposaccharide metabolism (HP:0010968)2.75487486
25Abnormality of glycosphingolipid metabolism (HP:0004343)2.75487486
26Colon cancer (HP:0003003)2.75487347
27Degeneration of anterior horn cells (HP:0002398)2.71897772
28Abnormality of the anterior horn cell (HP:0006802)2.71897772
29Trismus (HP:0000211)2.69601711
30Purpura (HP:0000979)2.67823705
31Abnormality of glycine metabolism (HP:0010895)2.65432236
32Abnormality of serine family amino acid metabolism (HP:0010894)2.65432236
33Type I transferrin isoform profile (HP:0003642)2.64281670
34Ragged-red muscle fibers (HP:0003200)2.64119638
35Hyperglycinuria (HP:0003108)2.63923587
36Recurrent abscess formation (HP:0002722)2.62991999
37Pallor (HP:0000980)2.62423904
38Xanthomatosis (HP:0000991)2.62398553
39Abnormality of aromatic amino acid family metabolism (HP:0004338)2.60657654
40Obstructive lung disease (HP:0006536)2.58450093
41Chronic obstructive pulmonary disease (HP:0006510)2.58450093
42Hyperammonemia (HP:0001987)2.56707347
43Vertebral compression fractures (HP:0002953)2.56467746
44Abnormality of serum amino acid levels (HP:0003112)2.53801743
45Deep venous thrombosis (HP:0002625)2.50978441
46Abnormality of macrophages (HP:0004311)2.50886347
47Prolonged partial thromboplastin time (HP:0003645)2.49741733
48Hepatosplenomegaly (HP:0001433)2.49082565
49Increased serum ferritin (HP:0003281)2.47860219
50Opisthotonus (HP:0002179)2.46536574
51Recurrent gram-negative bacterial infections (HP:0005420)2.45129976
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.44690020
53Increased cerebral lipofuscin (HP:0011813)2.43293587
54Increased muscle lipid content (HP:0009058)2.41856698
55Agammaglobulinemia (HP:0004432)2.38590774
56Amyloidosis (HP:0011034)2.38413297
57Progressive muscle weakness (HP:0003323)2.38398317
58Hemorrhage of the eye (HP:0011885)2.38085471
59Premature ovarian failure (HP:0008209)2.36394881
60Vacuolated lymphocytes (HP:0001922)2.35499807
61Spastic diplegia (HP:0001264)2.33842515
62Increased intramyocellular lipid droplets (HP:0012240)2.33293876
63Cellulitis (HP:0100658)2.32922880
64Abnormality of the Achilles tendon (HP:0005109)2.32749912
65Aplastic anemia (HP:0001915)2.32739399
66Hypertensive crisis (HP:0100735)2.32634785
67Nonimmune hydrops fetalis (HP:0001790)2.32194707
68Hypolipoproteinemia (HP:0010981)2.32046456
69Testicular atrophy (HP:0000029)2.29436033
70Abnormality of reticulocytes (HP:0004312)2.27275734
71Secondary amenorrhea (HP:0000869)2.26719530
72Abnormality of complement system (HP:0005339)2.23058452
73Reduced antithrombin III activity (HP:0001976)2.22912158
74Protrusio acetabuli (HP:0003179)2.20971178
75Recurrent bacterial skin infections (HP:0005406)2.19922130
76Abnormality of the umbilical cord (HP:0010881)2.19593677
77Ependymoma (HP:0002888)2.18799911
78Patellar aplasia (HP:0006443)2.16500403
79Aplasia/Hypoplasia of the patella (HP:0006498)2.14934455
80Thrombocytosis (HP:0001894)2.14796130
81Intrahepatic cholestasis (HP:0001406)2.14576994
82Neoplasm of the pancreas (HP:0002894)2.14525739
83Dysostosis multiplex (HP:0000943)2.13521561
84Achilles tendon contracture (HP:0001771)2.13396702
85Nausea (HP:0002018)2.12982013
86Abnormality of methionine metabolism (HP:0010901)2.11294862
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10913005
88Abnormal protein N-linked glycosylation (HP:0012347)2.10913005
89Abnormal protein glycosylation (HP:0012346)2.10913005
90Abnormal glycosylation (HP:0012345)2.10913005
91Impulsivity (HP:0100710)2.10499889
92Dicarboxylic aciduria (HP:0003215)2.10215869
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10215869
94Abnormal cartilage morphology (HP:0002763)2.09381029
95Mediastinal lymphadenopathy (HP:0100721)2.08468928
96Petechiae (HP:0000967)2.05355906
97Microvesicular hepatic steatosis (HP:0001414)2.05019439
98Hepatocellular necrosis (HP:0001404)2.04864695
99Elevated erythrocyte sedimentation rate (HP:0003565)2.04693164
100Abnormality of sulfur amino acid metabolism (HP:0004339)2.03364088
101Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01993335
102Complement deficiency (HP:0004431)2.00911794
103Meningitis (HP:0001287)2.00013889
104Polygenic inheritance (HP:0010982)1.97949839
105Progressive neurologic deterioration (HP:0002344)1.97940888
106Absent thumb (HP:0009777)1.96974679
107Cholelithiasis (HP:0001081)1.96947866
108Eczematoid dermatitis (HP:0000976)1.95511821
109Lethargy (HP:0001254)1.95025169
110Broad distal phalanx of finger (HP:0009836)1.94048658
111Mitochondrial inheritance (HP:0001427)1.93471734
112Increased serum lactate (HP:0002151)1.93271533
113Abnormal trabecular bone morphology (HP:0100671)1.93052326
114Abnormal mitochondria in muscle tissue (HP:0008316)1.90911766
115Respiratory difficulties (HP:0002880)1.89654881
116Lactic acidosis (HP:0003128)1.89630297
117Cerebral palsy (HP:0100021)1.89315461
118Rhabdomyosarcoma (HP:0002859)1.89220361
119Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.87846912
120Decreased activity of mitochondrial respiratory chain (HP:0008972)1.87846912
12111 pairs of ribs (HP:0000878)1.86995046
122Hypergonadotropic hypogonadism (HP:0000815)1.86100658
123Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.85987086
124Poor head control (HP:0002421)1.85639032
125Abnormality of glycolysis (HP:0004366)1.85576555
126Increased serum pyruvate (HP:0003542)1.85576555
127Pancytopenia (HP:0001876)1.85277348
128Premature graying of hair (HP:0002216)1.84967711
129Colitis (HP:0002583)1.83801870
130Absent radius (HP:0003974)1.83227090
131Squamous cell carcinoma (HP:0002860)1.83118568
132Hypoalphalipoproteinemia (HP:0003233)1.82187860
133Hypertriglyceridemia (HP:0002155)1.81900006
134Abnormal umbilical cord blood vessels (HP:0011403)1.81391518
135Single umbilical artery (HP:0001195)1.81391518
136Abnormality of the fetal cardiovascular system (HP:0010948)1.81391518
137Sparse eyelashes (HP:0000653)1.81134370
138Medulloblastoma (HP:0002885)1.80961984
139Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80162688
140Hyperlipoproteinemia (HP:0010980)1.79154000
141Renal Fanconi syndrome (HP:0001994)1.78983856
142Abnormality of iron homeostasis (HP:0011031)1.78932392
143Increased CSF lactate (HP:0002490)1.78891269
144Entropion (HP:0000621)1.78468003
145Myositis (HP:0100614)1.78115326
146Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.78098512
147Hypokinesia (HP:0002375)1.77310571
148Spastic paraparesis (HP:0002313)1.75739555
149Personality changes (HP:0000751)1.75129323
150Cellular immunodeficiency (HP:0005374)1.74656022
151J-shaped sella turcica (HP:0002680)1.74232488
152CNS demyelination (HP:0007305)1.73947458
153Stridor (HP:0010307)1.73895202
154Basal cell carcinoma (HP:0002671)1.72985454
155Recurrent viral infections (HP:0004429)1.72914789
156Abnormality of mucopolysaccharide metabolism (HP:0011020)1.72876064
157Abnormality of polysaccharide metabolism (HP:0011012)1.72876064
158Abnormality of glycosaminoglycan metabolism (HP:0004371)1.72876064
159Increased IgM level (HP:0003496)1.72845291
160Meckel diverticulum (HP:0002245)1.72378187
161Acute encephalopathy (HP:0006846)1.71727232
162Angiofibromas (HP:0010615)1.71600156
163Adenoma sebaceum (HP:0009720)1.71600156
164Rhabdomyolysis (HP:0003201)1.71508558
165Delayed CNS myelination (HP:0002188)1.71181509
166Abnormality of T cell physiology (HP:0011840)1.70724911
167Hypoglycemic coma (HP:0001325)1.69961382
168Agnosia (HP:0010524)1.69898360
169Abnormality of nucleobase metabolism (HP:0010932)1.68718703
170Abnormality of fatty-acid metabolism (HP:0004359)1.68224182
171Horseshoe kidney (HP:0000085)1.68187094
172Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.66652347
173Aplasia involving forearm bones (HP:0009822)1.65792785
174Absent forearm bone (HP:0003953)1.65792785
175Hepatic necrosis (HP:0002605)1.65774746
176Ureteral duplication (HP:0000073)1.64964652
177Gout (HP:0001997)1.64024099
178Bone marrow hypocellularity (HP:0005528)1.62773565

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.81436804
2WEE14.13814225
3VRK24.09499342
4SMG13.15240255
5NME23.08477115
6EIF2AK12.80493247
7EPHA22.55869718
8BCKDK2.54767676
9CDC72.48833943
10NEK22.35416816
11STK162.27104637
12TESK22.18224275
13PLK42.14646916
14TSSK62.02080741
15TTK2.01667009
16PKN22.01637652
17NEK12.01087320
18SCYL21.97351117
19RPS6KB21.94051518
20EEF2K1.83434206
21TLK11.79959311
22KDR1.71528597
23TRIB31.66202905
24ACVR1B1.63733429
25EIF2AK31.57727013
26SRPK11.56673411
27MAP3K111.54197532
28PLK11.53962285
29MAP3K81.50528358
30TBK11.49496944
31BRSK21.48546924
32PAK41.43231223
33CDK71.41832551
34MAP3K101.39432577
35CDK41.39056576
36RPS6KA41.36302373
37PIM21.35125953
38DYRK31.34360208
39PDK21.33796763
40AURKB1.33559014
41LRRK21.29393339
42FLT31.27850434
43DAPK11.22275688
44AURKA1.20951156
45LIMK11.19706093
46IRAK41.14199128
47MAP2K31.13182750
48PASK1.11877043
49SIK11.07049755
50STK101.06476978
51ATR1.05889569
52VRK11.05295333
53MUSK1.05235208
54MAP4K11.04553434
55ERN11.01397408
56TGFBR10.99706809
57ZAK0.99566369
58PRKD30.97611635
59CHEK20.95808219
60BRSK10.95707533
61PRPF4B0.91993430
62PLK30.90347566
63MKNK10.85100350
64TESK10.84659596
65ICK0.83546735
66PAK10.82756862
67PBK0.82483526
68TAOK20.82225477
69PIM10.80715154
70MARK30.80204176
71IKBKB0.78534874
72CHEK10.77643572
73IRAK30.77239109
74MAP2K20.76697204
75BRAF0.75982169
76MAP3K30.75420280
77STK40.73725623
78PRKCI0.70856204
79ILK0.69938142
80MAPKAPK30.69119245
81GRK60.66144124
82TNK20.65275505
83CSNK1G30.64761333
84LATS20.64225750
85PDPK10.63043092
86ABL20.62321377
87IKBKE0.60760994
88IRAK20.59692778
89CSF1R0.59582178
90CSNK2A20.59104006
91TAF10.57746939
92ZAP700.57549421
93CSNK2A10.57446039
94FES0.56353911
95CDK190.55366071
96CDK20.55101136
97NEK90.54992824
98JAK30.54497078
99AKT20.52918230
100MAP3K10.50008374
101PRKD20.49087585
102CDK60.49073361
103MATK0.48897535
104MTOR0.47923605
105NME10.46966286
106PAK20.46498878
107BLK0.45758066
108ALK0.45177736
109MAPKAPK20.45040271
110FGFR40.43336217
111CSNK1A1L0.42812650
112STK38L0.42151368
113KIT0.41537728
114RPS6KC10.41168505
115RPS6KL10.41168505
116CDK120.40546385
117CDK90.39812096
118DAPK30.39382380
119MAPK110.38871192
120RPS6KA20.38596771
121MKNK20.38002950
122ATM0.37896685
123ARAF0.37002018
124TIE10.36652156
125LMTK20.36599208
126RPS6KA50.34779050
127PRKG20.34253848
128STK30.33395752
129BTK0.32810935
130PDK10.32323126
131BMX0.32274462
132RPS6KA60.32159783
133PTK60.31066153
134CDK80.28621929
135TYK20.28487142
136PDK30.28297104
137PDK40.28297104
138CDK10.27601769
139CCNB10.27534136
140CSNK1E0.26817448
141FGFR10.26022022

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.96530956
2Ribosome_Homo sapiens_hsa030103.54880023
3Proteasome_Homo sapiens_hsa030503.18697159
4Mismatch repair_Homo sapiens_hsa034303.10183179
5One carbon pool by folate_Homo sapiens_hsa006702.83120180
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.72823763
7RNA polymerase_Homo sapiens_hsa030202.51449137
8Other glycan degradation_Homo sapiens_hsa005112.37560404
9Spliceosome_Homo sapiens_hsa030402.36380298
10Base excision repair_Homo sapiens_hsa034102.34983968
11RNA transport_Homo sapiens_hsa030132.30246581
12Pyrimidine metabolism_Homo sapiens_hsa002402.20272796
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16057705
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10226145
15Nucleotide excision repair_Homo sapiens_hsa034202.06637737
16Homologous recombination_Homo sapiens_hsa034401.99484065
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.90061214
18Folate biosynthesis_Homo sapiens_hsa007901.86036887
19Biosynthesis of amino acids_Homo sapiens_hsa012301.79293332
20Cell cycle_Homo sapiens_hsa041101.71786668
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.67537681
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.63737479
23Sulfur relay system_Homo sapiens_hsa041221.62543099
24Pentose phosphate pathway_Homo sapiens_hsa000301.61832827
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.60660629
26Selenocompound metabolism_Homo sapiens_hsa004501.60255867
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54778280
28Vitamin B6 metabolism_Homo sapiens_hsa007501.52918323
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.51993907
30Fatty acid elongation_Homo sapiens_hsa000621.50249844
31Oxidative phosphorylation_Homo sapiens_hsa001901.42896234
32Carbon metabolism_Homo sapiens_hsa012001.41967897
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34467244
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23691751
35Primary immunodeficiency_Homo sapiens_hsa053401.23146278
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20747419
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.17426245
38Fanconi anemia pathway_Homo sapiens_hsa034601.15791076
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14639897
40Glutathione metabolism_Homo sapiens_hsa004801.08298530
41p53 signaling pathway_Homo sapiens_hsa041151.03798249
42Fructose and mannose metabolism_Homo sapiens_hsa000511.03145871
43* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01355721
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00872060
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00747671
46RNA degradation_Homo sapiens_hsa030181.00445195
47Arginine biosynthesis_Homo sapiens_hsa002201.00362506
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00260435
49Sulfur metabolism_Homo sapiens_hsa009200.99276398
50Lysosome_Homo sapiens_hsa041420.97546481
51Purine metabolism_Homo sapiens_hsa002300.97541528
52Staphylococcus aureus infection_Homo sapiens_hsa051500.94534426
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92818782
54Arginine and proline metabolism_Homo sapiens_hsa003300.92163157
55Non-homologous end-joining_Homo sapiens_hsa034500.92124848
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90756862
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88555609
58Systemic lupus erythematosus_Homo sapiens_hsa053220.86855554
59Fatty acid degradation_Homo sapiens_hsa000710.83502057
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83460330
61Basal transcription factors_Homo sapiens_hsa030220.81955676
62Nitrogen metabolism_Homo sapiens_hsa009100.79375179
63Fat digestion and absorption_Homo sapiens_hsa049750.76233473
64mRNA surveillance pathway_Homo sapiens_hsa030150.75883997
65Pyruvate metabolism_Homo sapiens_hsa006200.72336940
66Epstein-Barr virus infection_Homo sapiens_hsa051690.72336148
67Tryptophan metabolism_Homo sapiens_hsa003800.70703104
68beta-Alanine metabolism_Homo sapiens_hsa004100.69995817
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68807909
70Complement and coagulation cascades_Homo sapiens_hsa046100.68707166
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67861976
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67230934
73Vitamin digestion and absorption_Homo sapiens_hsa049770.66653384
74Peroxisome_Homo sapiens_hsa041460.63708502
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63573776
76Propanoate metabolism_Homo sapiens_hsa006400.63211197
77Alzheimers disease_Homo sapiens_hsa050100.62249205
78Chemical carcinogenesis_Homo sapiens_hsa052040.60684474
79Arachidonic acid metabolism_Homo sapiens_hsa005900.57318891
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56471283
81Shigellosis_Homo sapiens_hsa051310.55602778
82Phenylalanine metabolism_Homo sapiens_hsa003600.54016090
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53871811
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53227928
85* Metabolic pathways_Homo sapiens_hsa011000.53224509
86Antigen processing and presentation_Homo sapiens_hsa046120.52250661
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51501398
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51468130
89Leishmaniasis_Homo sapiens_hsa051400.51124840
90Viral carcinogenesis_Homo sapiens_hsa052030.50918860
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50323790
92Allograft rejection_Homo sapiens_hsa053300.48952146
93Vibrio cholerae infection_Homo sapiens_hsa051100.47741438
94Tyrosine metabolism_Homo sapiens_hsa003500.46870927
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46755566
96Retinol metabolism_Homo sapiens_hsa008300.46212208
97* Galactose metabolism_Homo sapiens_hsa000520.45896150
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45623323
99Histidine metabolism_Homo sapiens_hsa003400.44724248
100Prion diseases_Homo sapiens_hsa050200.44525462
101Acute myeloid leukemia_Homo sapiens_hsa052210.43741409
102Apoptosis_Homo sapiens_hsa042100.41964084
103Pertussis_Homo sapiens_hsa051330.40595904
104Caffeine metabolism_Homo sapiens_hsa002320.39631721
105Graft-versus-host disease_Homo sapiens_hsa053320.39533679
106N-Glycan biosynthesis_Homo sapiens_hsa005100.38633960
107B cell receptor signaling pathway_Homo sapiens_hsa046620.37889719
108Thyroid cancer_Homo sapiens_hsa052160.37792121
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.37739852
110Butanoate metabolism_Homo sapiens_hsa006500.37044109
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36343611
112Osteoclast differentiation_Homo sapiens_hsa043800.36186303
113Fatty acid metabolism_Homo sapiens_hsa012120.35489073
114Protein export_Homo sapiens_hsa030600.35338867
115Bladder cancer_Homo sapiens_hsa052190.35235825
116Huntingtons disease_Homo sapiens_hsa050160.35182773
117HTLV-I infection_Homo sapiens_hsa051660.34289884
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.33626466
119Small cell lung cancer_Homo sapiens_hsa052220.33510659
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31141503
121Herpes simplex infection_Homo sapiens_hsa051680.30575770
122Legionellosis_Homo sapiens_hsa051340.29083971
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.28972762
124PPAR signaling pathway_Homo sapiens_hsa033200.27445054
125Parkinsons disease_Homo sapiens_hsa050120.27400781
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27239211
127Lysine degradation_Homo sapiens_hsa003100.26638058
128Starch and sucrose metabolism_Homo sapiens_hsa005000.26079857

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