GALK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a highly efficient N-acetylgalactosamine (GalNAc) kinase, which has galactokinase activity when galactose is present at high concentrations. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.73332197
2COPI coating of Golgi vesicle (GO:0048205)4.73332197
3signal peptide processing (GO:0006465)4.58243387
4cellular ketone body metabolic process (GO:0046950)4.31372814
5DNA strand renaturation (GO:0000733)4.27450769
6epithelial cilium movement (GO:0003351)4.10280346
7regulation of glucokinase activity (GO:0033131)3.96186664
8regulation of hexokinase activity (GO:1903299)3.96186664
9response to pheromone (GO:0019236)3.92496307
10ketone body metabolic process (GO:1902224)3.91000606
11regulation of RIG-I signaling pathway (GO:0039535)3.84297913
12NIK/NF-kappaB signaling (GO:0038061)3.82640066
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.79869957
14production of molecular mediator involved in inflammatory response (GO:0002532)3.77996517
15L-fucose metabolic process (GO:0042354)3.72911355
16L-fucose catabolic process (GO:0042355)3.72911355
17fucose catabolic process (GO:0019317)3.72911355
18necroptotic process (GO:0070266)3.60027702
19cullin deneddylation (GO:0010388)3.54072175
20behavioral response to nicotine (GO:0035095)3.53439440
21cilium movement (GO:0003341)3.52734495
22neutrophil activation involved in immune response (GO:0002283)3.52579668
23water-soluble vitamin biosynthetic process (GO:0042364)3.49361889
24mitochondrial respiratory chain complex I assembly (GO:0032981)3.44522406
25NADH dehydrogenase complex assembly (GO:0010257)3.44522406
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.44522406
27protein maturation by protein folding (GO:0022417)3.39584498
28indolalkylamine metabolic process (GO:0006586)3.37247140
29regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.34691463
30regulation of interferon-beta biosynthetic process (GO:0045357)3.34431775
31protein polyglutamylation (GO:0018095)3.33581927
32tryptophan catabolic process (GO:0006569)3.33166215
33indole-containing compound catabolic process (GO:0042436)3.33166215
34indolalkylamine catabolic process (GO:0046218)3.33166215
35positive regulation by symbiont of host defense response (GO:0052509)3.31390364
36modulation by symbiont of host defense response (GO:0052031)3.31390364
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.31390364
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.31390364
39positive regulation by organism of defense response of other organism involved in symbiotic interact3.31390364
40modulation by symbiont of host immune response (GO:0052553)3.31390364
41pyrimidine nucleobase catabolic process (GO:0006208)3.26674422
42regulation of B cell receptor signaling pathway (GO:0050855)3.25972274
43DNA deamination (GO:0045006)3.25478299
44neural tube formation (GO:0001841)3.23566028
45chaperone mediated protein folding requiring cofactor (GO:0051085)3.19683701
46mitochondrial DNA replication (GO:0006264)3.18174812
47pinocytosis (GO:0006907)3.17458855
48intraciliary transport (GO:0042073)3.17414077
49cellular response to interferon-beta (GO:0035458)3.17256333
50regulation of necroptotic process (GO:0060544)3.15111089
51negative regulation of phagocytosis (GO:0050765)3.13636118
52heparin biosynthetic process (GO:0030210)3.11861945
53heparin metabolic process (GO:0030202)3.11861945
54nucleobase catabolic process (GO:0046113)3.11715938
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.11685397
56cilium or flagellum-dependent cell motility (GO:0001539)3.11548250
57regulation of cilium movement (GO:0003352)3.11225453
58S-adenosylmethionine metabolic process (GO:0046500)3.09388080
59protein K11-linked deubiquitination (GO:0035871)3.08189578
60detection of light stimulus involved in sensory perception (GO:0050962)3.05153698
61detection of light stimulus involved in visual perception (GO:0050908)3.05153698
62tryptophan metabolic process (GO:0006568)3.04340252
63preassembly of GPI anchor in ER membrane (GO:0016254)3.03235642
64daunorubicin metabolic process (GO:0044597)3.02671382
65polyketide metabolic process (GO:0030638)3.02671382
66doxorubicin metabolic process (GO:0044598)3.02671382
67nucleotide transmembrane transport (GO:1901679)3.02138889
68mannosylation (GO:0097502)3.01571206
69positive regulation of interferon-alpha production (GO:0032727)2.99335120
70ubiquinone biosynthetic process (GO:0006744)2.98108373
71cilium organization (GO:0044782)2.97727208
72axoneme assembly (GO:0035082)2.97630041
73protein-cofactor linkage (GO:0018065)2.96747399
74cilium assembly (GO:0042384)2.91063523
75respiratory chain complex IV assembly (GO:0008535)2.89963751
76establishment of protein localization to mitochondrial membrane (GO:0090151)2.89523377
77endosome to pigment granule transport (GO:0043485)2.87889798
78endosome to melanosome transport (GO:0035646)2.87889798
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.86241014
80mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.85242672
81ribosomal small subunit assembly (GO:0000028)2.83758395
82programmed necrotic cell death (GO:0097300)2.83710984
83antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.82394690
84antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.82394690
85axonemal dynein complex assembly (GO:0070286)2.81544970
86hepatocyte apoptotic process (GO:0097284)2.79659785
87ubiquinone metabolic process (GO:0006743)2.79147904
88cilium morphogenesis (GO:0060271)2.78380845
89regulation of interferon-alpha production (GO:0032647)2.77730795
90positive regulation of glycolytic process (GO:0045821)2.76690964
91negative regulation of interleukin-17 production (GO:0032700)2.74792995
92establishment of protein localization to Golgi (GO:0072600)2.74260021
93glycoside metabolic process (GO:0016137)2.74162395
94kynurenine metabolic process (GO:0070189)2.73994680
95negative regulation of necroptotic process (GO:0060546)2.73622603
96positive regulation of B cell differentiation (GO:0045579)2.73500330
97GPI anchor metabolic process (GO:0006505)2.73426679
98response to interferon-beta (GO:0035456)2.72047869
99detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.71841393
100piRNA metabolic process (GO:0034587)2.71039052
101positive regulation of gamma-delta T cell activation (GO:0046645)2.70700442
102dopamine transport (GO:0015872)2.67577631
103response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66001682
104response to host immune response (GO:0052572)2.66001682
105prenylation (GO:0097354)2.65856152
106protein prenylation (GO:0018342)2.65856152
107aldehyde catabolic process (GO:0046185)2.65531115
108anterograde synaptic vesicle transport (GO:0048490)2.64814066
109respiratory burst (GO:0045730)2.64723655
110positive regulation of natural killer cell differentiation (GO:0032825)2.64693971
111fucose metabolic process (GO:0006004)2.64653999
112oxidative demethylation (GO:0070989)2.62852751
113interferon-gamma production (GO:0032609)2.62447034
114branched-chain amino acid catabolic process (GO:0009083)2.61760843
115inositol phosphate catabolic process (GO:0071545)2.61271603
116negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61068563
117protein deneddylation (GO:0000338)2.60988162
118protein targeting to Golgi (GO:0000042)2.60596236
119antigen processing and presentation of endogenous antigen (GO:0019883)2.60412558
120positive regulation of fatty acid transport (GO:2000193)2.58675853
121aromatic amino acid family catabolic process (GO:0009074)2.58583371
122drug catabolic process (GO:0042737)2.57731729
123misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.56870207
124Arp2/3 complex-mediated actin nucleation (GO:0034314)2.56530188
125negative regulation of telomere maintenance (GO:0032205)2.56461976
126exogenous drug catabolic process (GO:0042738)2.55544771
127antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.55167613
128DNA double-strand break processing (GO:0000729)2.54519537
129antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.54363744
130DNA integration (GO:0015074)2.54258477
131protein K6-linked ubiquitination (GO:0085020)2.54229536
132amine catabolic process (GO:0009310)2.53272565
133cellular biogenic amine catabolic process (GO:0042402)2.53272565
134folic acid-containing compound biosynthetic process (GO:0009396)2.52698699
135regulation of necrotic cell death (GO:0010939)2.52489327
136quinone biosynthetic process (GO:1901663)2.50356108
137negative regulation of acute inflammatory response (GO:0002674)2.49731496
138positive regulation of prostaglandin secretion (GO:0032308)2.49585919
139sperm motility (GO:0030317)2.49457686
140indole-containing compound metabolic process (GO:0042430)2.49237350
141response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.48177870
142response to host (GO:0075136)2.48177870
143response to host defenses (GO:0052200)2.48177870
144glycerophospholipid catabolic process (GO:0046475)2.47925880
145GPI anchor biosynthetic process (GO:0006506)2.47793472
146positive regulation of growth hormone secretion (GO:0060124)2.47488027
147tachykinin receptor signaling pathway (GO:0007217)2.47259031
148endocrine pancreas development (GO:0031018)2.46714251
149antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.46410404
150necrotic cell death (GO:0070265)2.46316508
151mast cell activation (GO:0045576)2.46303996
152inositol phosphate dephosphorylation (GO:0046855)2.46121035
153phosphorylated carbohydrate dephosphorylation (GO:0046838)2.46121035
154amino acid salvage (GO:0043102)2.46005209
155L-methionine salvage (GO:0071267)2.46005209
156L-methionine biosynthetic process (GO:0071265)2.46005209
157toxin transport (GO:1901998)2.45939531
158nucleotide-sugar metabolic process (GO:0009225)2.44910773
159regulation of B cell differentiation (GO:0045577)2.43983316
160polyol catabolic process (GO:0046174)2.43321708
161cell wall macromolecule catabolic process (GO:0016998)2.42201555
162sequestering of actin monomers (GO:0042989)2.42062032
163replication fork processing (GO:0031297)2.41888920
164protein retention in ER lumen (GO:0006621)2.41425676
165positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.40699934
166myeloid cell activation involved in immune response (GO:0002275)2.40364602
167sulfation (GO:0051923)2.37203591
168GDP-mannose metabolic process (GO:0019673)2.36949526
169I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.36702799
170mitochondrial respiratory chain complex assembly (GO:0033108)2.36682629
171C-terminal protein amino acid modification (GO:0018410)2.36256893
172L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.36148003
173transcription from mitochondrial promoter (GO:0006390)2.35128301
174DNA catabolic process, exonucleolytic (GO:0000738)2.32523360
175aminoglycoside antibiotic metabolic process (GO:0030647)2.32439083
176protein complex biogenesis (GO:0070271)2.29944789
177leukocyte degranulation (GO:0043299)2.29720047
178regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.29084718
179negative regulation of mast cell activation (GO:0033004)2.28795323
180lymph node development (GO:0048535)2.27551608
181negative regulation of necrotic cell death (GO:0060547)2.26753522
182IMP biosynthetic process (GO:0006188)2.26290698
183pteridine-containing compound biosynthetic process (GO:0042559)2.25896480
184metallo-sulfur cluster assembly (GO:0031163)2.24567682
185iron-sulfur cluster assembly (GO:0016226)2.24567682
186myeloid dendritic cell activation (GO:0001773)2.23834365
187deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.23381101
188sequestering of metal ion (GO:0051238)2.22806093
189platelet dense granule organization (GO:0060155)2.22473776
190negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.22333703
191negative thymic T cell selection (GO:0045060)2.22132613
192negative regulation of DNA-dependent DNA replication (GO:2000104)2.22102155
193protein localization to cilium (GO:0061512)2.21972101

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.93571814
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.95473434
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.40305484
4ZNF274_21170338_ChIP-Seq_K562_Hela3.31690031
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.15768311
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.06567190
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.01797556
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.01349421
9VDR_22108803_ChIP-Seq_LS180_Human2.98737214
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.98544990
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.93129119
12* GABP_17652178_ChIP-ChIP_JURKAT_Human2.81979318
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.74555476
14IGF1R_20145208_ChIP-Seq_DFB_Human2.65816965
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.59654217
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59317978
17* EST1_17652178_ChIP-ChIP_JURKAT_Human2.58555997
18GBX2_23144817_ChIP-Seq_PC3_Human2.57414990
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.51859380
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50132900
21FUS_26573619_Chip-Seq_HEK293_Human2.40876468
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40511754
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.38602060
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.37261131
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34938461
26* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.34466369
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.32172858
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.27592692
29MYC_18555785_ChIP-Seq_MESCs_Mouse2.23979314
30* HOXB4_20404135_ChIP-ChIP_EML_Mouse2.23210342
31EWS_26573619_Chip-Seq_HEK293_Human2.22730619
32NOTCH1_21737748_ChIP-Seq_TLL_Human2.21353849
33TAF15_26573619_Chip-Seq_HEK293_Human2.14649699
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.11824665
35* FOXP3_21729870_ChIP-Seq_TREG_Human2.10275134
36ERG_20887958_ChIP-Seq_HPC-7_Mouse2.10187373
37* VDR_23849224_ChIP-Seq_CD4+_Human2.08845029
38ELK1_19687146_ChIP-ChIP_HELA_Human2.08485870
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07965452
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.06028162
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.05688662
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.04210994
43SALL1_21062744_ChIP-ChIP_HESCs_Human2.03192368
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01497033
45CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00495987
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00204255
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00166233
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.99884918
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99361692
50SPI1_23547873_ChIP-Seq_NB4_Human1.99240866
51P300_19829295_ChIP-Seq_ESCs_Human1.93649969
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93429784
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90517982
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89269829
55TFEB_21752829_ChIP-Seq_HELA_Human1.86158340
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.84027886
57* ER_23166858_ChIP-Seq_MCF-7_Human1.82813019
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82721505
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79703358
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79187028
61DCP1A_22483619_ChIP-Seq_HELA_Human1.75235831
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74036459
63* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73128583
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.69676531
65IRF8_27001747_Chip-Seq_BMDM_Mouse1.68775270
66NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68708947
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68179363
68* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.68131952
69* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65188969
70GABP_19822575_ChIP-Seq_HepG2_Human1.63543669
71CBP_20019798_ChIP-Seq_JUKART_Human1.63000148
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63000148
73E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61834870
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61743800
75SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61283227
76IRF1_19129219_ChIP-ChIP_H3396_Human1.61154150
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59793386
78FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58837490
79BP1_19119308_ChIP-ChIP_Hs578T_Human1.55158222
80SMAD4_21799915_ChIP-Seq_A2780_Human1.55135394
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54877662
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54018779
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.52786191
84STAT3_23295773_ChIP-Seq_U87_Human1.52627168
85* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52537699
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50916289
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.50867347
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49818157
89CIITA_25753668_ChIP-Seq_RAJI_Human1.48813235
90CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48595381
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.48094875
92BCAT_22108803_ChIP-Seq_LS180_Human1.45453321
93* TP53_22573176_ChIP-Seq_HFKS_Human1.45375617
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45119972
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44729746
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44498795
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.44308309
98NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43270584
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42778109
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41258870
101MYB_26560356_Chip-Seq_TH2_Human1.41112050
102NANOG_19829295_ChIP-Seq_ESCs_Human1.40924715
103SOX2_19829295_ChIP-Seq_ESCs_Human1.40924715
104MYC_18940864_ChIP-ChIP_HL60_Human1.39871863
105IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39655220
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36718409
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36636018
108PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36526972
109E2F1_21310950_ChIP-Seq_MCF-7_Human1.36413409
110AR_25329375_ChIP-Seq_VCAP_Human1.35015343
111TCF4_23295773_ChIP-Seq_U87_Human1.33363845
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32541980
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31108954
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29319252
115FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28742963
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.28742963
117FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28362903
118XRN2_22483619_ChIP-Seq_HELA_Human1.27782427
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27379879
120TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26983444
121SMAD3_21741376_ChIP-Seq_EPCs_Human1.26281723
122STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26047933
123* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25725996
124* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24027931
125* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23475597
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23392408
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23073622
128SCL_19346495_ChIP-Seq_HPC-7_Human1.22145301
129AR_20517297_ChIP-Seq_VCAP_Human1.21146429
130* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20987502
131RUNX1_22412390_ChIP-Seq_EML_Mouse1.20706703
132Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20512218
133NCOR_22424771_ChIP-Seq_293T_Human1.20262118
134LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19880409
135* P53_22387025_ChIP-Seq_ESCs_Mouse1.19652424
136HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19454975
137CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18736424
138* NANOG_18555785_Chip-Seq_ESCs_Mouse1.17990118
139GATA1_22025678_ChIP-Seq_K562_Human1.17928776
140TCF4_22108803_ChIP-Seq_LS180_Human1.16907822
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16462562
142THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16361373
143CRX_20693478_ChIP-Seq_RETINA_Mouse1.16290317
144MYB_26560356_Chip-Seq_TH1_Human1.16045781
145YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15951606
146GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15058076
147ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14370923
148ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13306328
149CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11363366
150* STAT3_18555785_Chip-Seq_ESCs_Mouse1.08192154
151GATA3_21878914_ChIP-Seq_MCF-7_Human1.07510183
152TAL1_26923725_Chip-Seq_HPCs_Mouse1.07106159
153BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06156252
154RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05733860
155* RUNX2_22187159_ChIP-Seq_PCA_Human1.05179226
156CDX2_22108803_ChIP-Seq_LS180_Human1.05063009
157PRDM14_20953172_ChIP-Seq_ESCs_Human1.04828510
158GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04319957
159AR_21572438_ChIP-Seq_LNCaP_Human1.03463066
160SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03325113
161* E2F1_18555785_Chip-Seq_ESCs_Mouse1.03281023
162HTT_18923047_ChIP-ChIP_STHdh_Human1.03238277
163CBX2_27304074_Chip-Seq_ESCs_Mouse1.02175279
164* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01794939
165MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01626098
166CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01212099
167FLI1_21867929_ChIP-Seq_TH2_Mouse1.00873221
168SMAD4_21741376_ChIP-Seq_EPCs_Human1.00352579
169CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99076519
170TTF2_22483619_ChIP-Seq_HELA_Human0.98968647
171FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98878332
172* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97798207
173CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97366412
174GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96745693
175PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96389839
176CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96342613
177* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96070054
178CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95988281
179PU_27001747_Chip-Seq_BMDM_Mouse0.94925237
180BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94823886
181BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94598430
182E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94107138
183MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93512194
184GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91275994
185MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90415978
186GATA3_27048872_Chip-Seq_THYMUS_Human0.90082252

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.98625158
2MP0002102_abnormal_ear_morphology3.93757450
3MP0001835_abnormal_antigen_presentation3.13654512
4MP0002138_abnormal_hepatobiliary_system3.10793006
5MP0005058_abnormal_lysosome_morphology3.02800556
6MP0002139_abnormal_hepatobiliary_system2.69018812
7MP0010386_abnormal_urinary_bladder2.65460123
8MP0008875_abnormal_xenobiotic_pharmacok2.51826082
9MP0009785_altered_susceptibility_to2.51677487
10MP0005671_abnormal_response_to2.50500379
11MP0006072_abnormal_retinal_apoptosis2.49790236
12MP0003183_abnormal_peptide_metabolism2.32193777
13MP0005379_endocrine/exocrine_gland_phen2.26184703
14MP0008877_abnormal_DNA_methylation2.25505899
15MP0005551_abnormal_eye_electrophysiolog2.21904732
16MP0003011_delayed_dark_adaptation2.15694590
17MP0002396_abnormal_hematopoietic_system2.11114839
18MP0005085_abnormal_gallbladder_physiolo2.07325331
19MP0001986_abnormal_taste_sensitivity2.06328011
20MP0009697_abnormal_copulation2.05938840
21MP0005174_abnormal_tail_pigmentation2.04631857
22MP0005645_abnormal_hypothalamus_physiol2.04339322
23MP0003763_abnormal_thymus_physiology2.01211261
24MP0003252_abnormal_bile_duct1.99583148
25MP0000372_irregular_coat_pigmentation1.97959460
26MP0002638_abnormal_pupillary_reflex1.96650007
27MP0002148_abnormal_hypersensitivity_rea1.95767051
28MP0002877_abnormal_melanocyte_morpholog1.95180472
29MP0004147_increased_porphyrin_level1.93697017
30MP0005253_abnormal_eye_physiology1.90357143
31MP0003172_abnormal_lysosome_physiology1.89387485
32MP0000015_abnormal_ear_pigmentation1.87736232
33MP0002419_abnormal_innate_immunity1.86761025
34MP0002837_dystrophic_cardiac_calcinosis1.84045794
35MP0008007_abnormal_cellular_replicative1.83204608
36MP0005000_abnormal_immune_tolerance1.82774697
37MP0002693_abnormal_pancreas_physiology1.82508176
38MP0000685_abnormal_immune_system1.81107032
39MP0005025_abnormal_response_to1.77957767
40MP0001790_abnormal_immune_system1.76301024
41MP0005387_immune_system_phenotype1.76301024
42MP0003787_abnormal_imprinting1.76035098
43MP0003436_decreased_susceptibility_to1.74211102
44MP0005464_abnormal_platelet_physiology1.72395255
45MP0005075_abnormal_melanosome_morpholog1.70577364
46MP0002452_abnormal_antigen_presenting1.68391223
47MP0008872_abnormal_physiological_respon1.65699951
48MP0001984_abnormal_olfaction1.64936350
49MP0000490_abnormal_crypts_of1.62888073
50MP0002420_abnormal_adaptive_immunity1.62408459
51MP0001819_abnormal_immune_cell1.62368884
52MP0002163_abnormal_gland_morphology1.62206368
53MP0002723_abnormal_immune_serum1.61144946
54MP0009046_muscle_twitch1.58791842
55MP0003693_abnormal_embryo_hatching1.58525805
56MP0000427_abnormal_hair_cycle1.56669613
57MP0004808_abnormal_hematopoietic_stem1.56321101
58MP0006276_abnormal_autonomic_nervous1.56218125
59MP0003880_abnormal_central_pattern1.56102722
60MP0001800_abnormal_humoral_immune1.55277040
61MP0005310_abnormal_salivary_gland1.50978580
62MP0009333_abnormal_splenocyte_physiolog1.50257450
63MP0004142_abnormal_muscle_tone1.49409733
64MP0003186_abnormal_redox_activity1.47583010
65MP0001188_hyperpigmentation1.46765396
66MP0008438_abnormal_cutaneous_collagen1.46003097
67MP0002160_abnormal_reproductive_system1.45419342
68MP0004043_abnormal_pH_regulation1.44698484
69MP0002398_abnormal_bone_marrow1.44566679
70MP0006054_spinal_hemorrhage1.43237905
71MP0000689_abnormal_spleen_morphology1.41659136
72MP0010155_abnormal_intestine_physiology1.39653506
73MP0002272_abnormal_nervous_system1.39314950
74MP0005389_reproductive_system_phenotype1.39191178
75MP0005220_abnormal_exocrine_pancreas1.38090626
76MP0000858_altered_metastatic_potential1.37107580
77MP0000716_abnormal_immune_system1.34885686
78MP0000371_diluted_coat_color1.34758203
79MP0002166_altered_tumor_susceptibility1.34246885
80MP0001845_abnormal_inflammatory_respons1.33496253
81MP0003136_yellow_coat_color1.33214186
82MP0002928_abnormal_bile_duct1.32937727
83MP0006082_CNS_inflammation1.32432866
84MP0005257_abnormal_intraocular_pressure1.29993927
85MP0005408_hypopigmentation1.28668716
86MP0002735_abnormal_chemical_nociception1.28566415
87MP0002722_abnormal_immune_system1.27520854
88MP0005365_abnormal_bile_salt1.27381780
89MP0005332_abnormal_amino_acid1.27320138
90MP0002876_abnormal_thyroid_physiology1.27016218
91MP0003943_abnormal_hepatobiliary_system1.25186608
92MP0003279_aneurysm1.24460464
93MP0003724_increased_susceptibility_to1.23746708
94MP0002429_abnormal_blood_cell1.23077954
95MP0002405_respiratory_system_inflammati1.22544699
96MP0001944_abnormal_pancreas_morphology1.22080400
97MP0003866_abnormal_defecation1.21596780
98MP0008058_abnormal_DNA_repair1.21135106
99MP0001968_abnormal_touch/_nociception1.19001554
100MP0010094_abnormal_chromosome_stability1.18562928
101MP0003718_maternal_effect1.17637157
102MP0003195_calcinosis1.15756226
103MP0002909_abnormal_adrenal_gland1.15269556
104MP0002736_abnormal_nociception_after1.14428007
105MP0004885_abnormal_endolymph1.14186734
106MP0001529_abnormal_vocalization1.14094814
107MP0008469_abnormal_protein_level1.13103080
108MP0002006_tumorigenesis1.12567269
109MP0005410_abnormal_fertilization1.11313837
110MP0002095_abnormal_skin_pigmentation1.11136413
111MP0009840_abnormal_foam_cell1.09738830
112MP0008057_abnormal_DNA_replication1.09433768
113MP0005084_abnormal_gallbladder_morpholo1.08448452
114MP0000631_abnormal_neuroendocrine_gland1.05914767
115MP0000538_abnormal_urinary_bladder1.05869137
116MP0003868_abnormal_feces_composition1.05184491
117MP0008995_early_reproductive_senescence1.05181694
118MP0003123_paternal_imprinting1.05122857
119MP0003806_abnormal_nucleotide_metabolis1.03856565
120MP0000013_abnormal_adipose_tissue1.03008981
121MP0001905_abnormal_dopamine_level1.02145012
122MP0004782_abnormal_surfactant_physiolog1.00883396
123MP0006292_abnormal_olfactory_placode1.00432121
124MP0001533_abnormal_skeleton_physiology1.00389371
125MP0001186_pigmentation_phenotype0.99879659
126MP0009745_abnormal_behavioral_response0.99309072
127MP0009643_abnormal_urine_homeostasis0.99062369
128MP0004133_heterotaxia0.99018742
129MP0005171_absent_coat_pigmentation0.98884981
130MP0002933_joint_inflammation0.98627796
131MP0000703_abnormal_thymus_morphology0.98577721
132MP0005646_abnormal_pituitary_gland0.98126006
133MP0006036_abnormal_mitochondrial_physio0.95278293
134MP0001919_abnormal_reproductive_system0.94846310
135MP0001666_abnormal_nutrient_absorption0.94060298
136MP0000681_abnormal_thyroid_gland0.94035073
137MP0002653_abnormal_ependyma_morphology0.92227711
138MP0004145_abnormal_muscle_electrophysio0.92175024
139MP0001324_abnormal_eye_pigmentation0.91636303
140MP0002557_abnormal_social/conspecific_i0.91555813
141MP0010307_abnormal_tumor_latency0.91493434
142MP0005636_abnormal_mineral_homeostasis0.90881607
143MP0002938_white_spotting0.89807701
144MP0002075_abnormal_coat/hair_pigmentati0.88926765
145MP0002132_abnormal_respiratory_system0.88704512
146MP0001929_abnormal_gametogenesis0.88463360
147MP0001764_abnormal_homeostasis0.87790158
148MP0005386_behavior/neurological_phenoty0.87524821
149MP0004924_abnormal_behavior0.87524821
150MP0009764_decreased_sensitivity_to0.85206393
151MP0003698_abnormal_male_reproductive0.84784366
152MP0003122_maternal_imprinting0.83434139
153MP0000383_abnormal_hair_follicle0.83035197
154MP0000358_abnormal_cell_content/0.81664264
155MP0002019_abnormal_tumor_incidence0.81455621
156MP0001970_abnormal_pain_threshold0.79942884
157MP0005195_abnormal_posterior_eye0.79659754
158MP0004019_abnormal_vitamin_homeostasis0.79651493
159MP0002822_catalepsy0.78578627
160MP0002751_abnormal_autonomic_nervous0.77307400
161MP0002572_abnormal_emotion/affect_behav0.75116617
162MP0002229_neurodegeneration0.74763476
163MP0001756_abnormal_urination0.74445542
164MP0004215_abnormal_myocardial_fiber0.74271955
165MP0003121_genomic_imprinting0.72951541
166MP0002184_abnormal_innervation0.71430275
167MP0005266_abnormal_metabolism0.71285083
168MP0008789_abnormal_olfactory_epithelium0.70810884
169MP0008775_abnormal_heart_ventricle0.70587914
170MP0003646_muscle_fatigue0.70287932
171MP0002277_abnormal_respiratory_mucosa0.69778189

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.14294220
2Pancreatic fibrosis (HP:0100732)4.08059700
3Vacuolated lymphocytes (HP:0001922)3.98844253
4Abnormality of midbrain morphology (HP:0002418)3.67894299
5Molar tooth sign on MRI (HP:0002419)3.67894299
6IgM deficiency (HP:0002850)3.66647352
7Decreased circulating renin level (HP:0003351)3.32347769
8Patchy hypopigmentation of hair (HP:0011365)3.17185148
9Nephronophthisis (HP:0000090)3.12786249
10Hypothermia (HP:0002045)3.09289099
11Aplastic anemia (HP:0001915)3.03753106
12Recurrent abscess formation (HP:0002722)3.02894053
13Increased neuronal autofluorescent lipopigment (HP:0002074)3.02297517
14Congenital stationary night blindness (HP:0007642)2.96508562
15Ketoacidosis (HP:0001993)2.90894916
16Beaking of vertebral bodies (HP:0004568)2.87072304
17Abnormality of the renal cortex (HP:0011035)2.81320655
18Hypoglycemic seizures (HP:0002173)2.79456049
19Abolished electroretinogram (ERG) (HP:0000550)2.76389937
20Progressive macrocephaly (HP:0004481)2.73868439
21Absent/shortened dynein arms (HP:0200106)2.68514032
22Dynein arm defect of respiratory motile cilia (HP:0012255)2.68514032
23Symptomatic seizures (HP:0011145)2.67050969
24Abnormality of the renal medulla (HP:0100957)2.65283790
25Increased cerebral lipofuscin (HP:0011813)2.64831182
26Degeneration of anterior horn cells (HP:0002398)2.63487629
27Abnormality of the anterior horn cell (HP:0006802)2.63487629
28Abnormal respiratory epithelium morphology (HP:0012253)2.63038227
29Abnormal respiratory motile cilium morphology (HP:0005938)2.63038227
30Gait imbalance (HP:0002141)2.60781284
31Renal cortical cysts (HP:0000803)2.60024895
32Cystic liver disease (HP:0006706)2.59868976
33Elevated erythrocyte sedimentation rate (HP:0003565)2.59710959
34Hypoplasia of the thymus (HP:0000778)2.58515310
35Congenital primary aphakia (HP:0007707)2.58081437
36Mediastinal lymphadenopathy (HP:0100721)2.58080405
37Chronic hepatic failure (HP:0100626)2.56741338
38Nephrogenic diabetes insipidus (HP:0009806)2.54877595
39Ketosis (HP:0001946)2.52692615
40Vertebral compression fractures (HP:0002953)2.51597601
41Acute encephalopathy (HP:0006846)2.51590913
42Myositis (HP:0100614)2.49786638
43Abnormal rod and cone electroretinograms (HP:0008323)2.49370439
44Attenuation of retinal blood vessels (HP:0007843)2.47522759
45Spinal muscular atrophy (HP:0007269)2.46285195
46Type II lissencephaly (HP:0007260)2.44731575
47Dysostosis multiplex (HP:0000943)2.43753397
48Urinary glycosaminoglycan excretion (HP:0003541)2.41495716
49Mucopolysacchariduria (HP:0008155)2.41495716
50Furrowed tongue (HP:0000221)2.40799611
51Thrombocytosis (HP:0001894)2.40159866
52Hyperventilation (HP:0002883)2.39551306
53Abnormal ciliary motility (HP:0012262)2.39516403
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.38382383
55Male pseudohermaphroditism (HP:0000037)2.34320097
56Abnormality of T cell number (HP:0011839)2.33946032
57Recurrent bacterial skin infections (HP:0005406)2.33568002
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32681195
59IgG deficiency (HP:0004315)2.29186740
60Rhinitis (HP:0012384)2.28769069
61Abnormal respiratory motile cilium physiology (HP:0012261)2.27794959
623-Methylglutaconic aciduria (HP:0003535)2.25792935
63Abnormal protein glycosylation (HP:0012346)2.25757076
64Abnormal glycosylation (HP:0012345)2.25757076
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25757076
66Abnormal protein N-linked glycosylation (HP:0012347)2.25757076
67Agnosia (HP:0010524)2.24581979
68Albinism (HP:0001022)2.23507470
69Aplasia/Hypoplasia of the fovea (HP:0008060)2.22546996
70Hypoplasia of the fovea (HP:0007750)2.22546996
71Abnormality of macrophages (HP:0004311)2.22477299
72Type I transferrin isoform profile (HP:0003642)2.22361296
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.22036101
74Methylmalonic acidemia (HP:0002912)2.21510182
75Abnormality of the pons (HP:0007361)2.20952775
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20064388
77Abnormality of alanine metabolism (HP:0010916)2.20064388
78Hyperalaninemia (HP:0003348)2.20064388
79Abnormality of polysaccharide metabolism (HP:0011012)2.19828670
80Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19828670
81Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19828670
82Lipid accumulation in hepatocytes (HP:0006561)2.19793678
83Pendular nystagmus (HP:0012043)2.17983477
84Tubular atrophy (HP:0000092)2.17015459
85Hypoglycemic coma (HP:0001325)2.16958618
86Optic disc pallor (HP:0000543)2.13824017
87T lymphocytopenia (HP:0005403)2.13279695
88Progressive cerebellar ataxia (HP:0002073)2.12895872
89Hepatic necrosis (HP:0002605)2.12659833
90Bile duct proliferation (HP:0001408)2.12271721
91Abnormal biliary tract physiology (HP:0012439)2.12271721
92Abnormality of the fovea (HP:0000493)2.11597714
93Agitation (HP:0000713)2.10856981
94Abnormal delayed hypersensitivity skin test (HP:0002963)2.09939261
95Abnormality of T cell physiology (HP:0011840)2.09245530
96Congenital hepatic fibrosis (HP:0002612)2.08870307
97Recurrent viral infections (HP:0004429)2.07150997
98Broad-based gait (HP:0002136)2.06927256
99Sclerocornea (HP:0000647)2.05966534
100Generalized aminoaciduria (HP:0002909)2.04717204
101Cerebral edema (HP:0002181)2.04371022
102Neoplasm of head and neck (HP:0012288)2.03922893
103Esophageal neoplasm (HP:0100751)2.03922893
104Decreased central vision (HP:0007663)2.03295566
105Hyperinsulinemic hypoglycemia (HP:0000825)2.03264926
106Abnormal drinking behavior (HP:0030082)2.02786921
107Polydipsia (HP:0001959)2.02786921
108Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00061268
109Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00061268
110Aplasia/hypoplasia of the uterus (HP:0008684)1.99865920
111Reduced antithrombin III activity (HP:0001976)1.98847211
112Genital tract atresia (HP:0001827)1.98740119
113Hypoplasia of the uterus (HP:0000013)1.98544246
114IgA deficiency (HP:0002720)1.97505826
115Exertional dyspnea (HP:0002875)1.97171113
116Microvesicular hepatic steatosis (HP:0001414)1.96886979
117True hermaphroditism (HP:0010459)1.95705738
118Abnormality of T cells (HP:0002843)1.95448177
119Methylmalonic aciduria (HP:0012120)1.92278101
120Hepatocellular necrosis (HP:0001404)1.92119449
121Mitochondrial inheritance (HP:0001427)1.92027229
122Increased serum lactate (HP:0002151)1.90649977
123Recurrent fungal infections (HP:0002841)1.90393929
124Pulmonary infiltrates (HP:0002113)1.89907539
125Calf muscle hypertrophy (HP:0008981)1.89162943
126Fair hair (HP:0002286)1.89088208
127Vaginal atresia (HP:0000148)1.88418641
128Aplasia/Hypoplasia of the tibia (HP:0005772)1.86977193
129Abnormal mitochondria in muscle tissue (HP:0008316)1.86677006
130Petechiae (HP:0000967)1.86587901
131Orchitis (HP:0100796)1.86066786
132Bony spicule pigmentary retinopathy (HP:0007737)1.84958548
133Chronic bronchitis (HP:0004469)1.84609513
134Occipital encephalocele (HP:0002085)1.84041209
135Lymphoma (HP:0002665)1.82747657
136Hypomagnesemia (HP:0002917)1.82697892
137White forelock (HP:0002211)1.82454527
138Lethargy (HP:0001254)1.81800327
139Absent speech (HP:0001344)1.81296820
140Cerebellar dysplasia (HP:0007033)1.81133312
141Abnormality of macular pigmentation (HP:0008002)1.80785656
14211 pairs of ribs (HP:0000878)1.79984239
143Thyroiditis (HP:0100646)1.79983136
144Gaze-evoked nystagmus (HP:0000640)1.79501934
145Postaxial hand polydactyly (HP:0001162)1.77636239
146Bronchitis (HP:0012387)1.76515992
147Congenital, generalized hypertrichosis (HP:0004540)1.76506728
148Neutropenia (HP:0001875)1.75326182
149Lactic acidosis (HP:0003128)1.75296478
150Anencephaly (HP:0002323)1.75230215
151Eczematoid dermatitis (HP:0000976)1.74845211
152Abnormality of urine glucose concentration (HP:0011016)1.72773338
153Glycosuria (HP:0003076)1.72773338
154Hyperactive renin-angiotensin system (HP:0000841)1.72407680
155Retrobulbar optic neuritis (HP:0100654)1.72368168
156Optic neuritis (HP:0100653)1.72368168
157Abnormality of the prostate (HP:0008775)1.72236970
158Limb hypertonia (HP:0002509)1.72153986
159Large for gestational age (HP:0001520)1.71151315
160Recurrent bronchitis (HP:0002837)1.71120312
161Increased CSF lactate (HP:0002490)1.70417122
162Abnormality of cells of the lymphoid lineage (HP:0012140)1.70393741
163Granulocytopenia (HP:0001913)1.69896289
164Prostate neoplasm (HP:0100787)1.68887172
165Abnormality of eosinophils (HP:0001879)1.67516979
166Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.67203258
167Acute necrotizing encephalopathy (HP:0006965)1.66722304
168Increased hepatocellular lipid droplets (HP:0006565)1.66079888
169Medial flaring of the eyebrow (HP:0010747)1.65712478
170Recurrent skin infections (HP:0001581)1.65308437
171Lymphopenia (HP:0001888)1.64264225
172Exercise intolerance (HP:0003546)1.63293295
173Hypoplasia of the pons (HP:0012110)1.62630413
174Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.61810847
175Tubulointerstitial nephritis (HP:0001970)1.61636231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.92321133
2FLT33.83679478
3EIF2AK13.24493201
4MAP4K23.13628409
5STK243.13435854
6STK33.06875721
7IRAK42.56554701
8KIT2.54197577
9MAP3K42.53728115
10PIM22.46051532
11PASK2.37228638
12WNK32.34857265
13MAP3K142.30353025
14PIK3CG2.20348544
15MAP2K32.14290988
16TXK2.13078363
17MAP3K122.07837024
18TBK12.07609878
19TEC2.04934053
20PINK11.97040652
21MAP4K11.91086114
22IRAK31.87508379
23INSRR1.85000232
24MAP2K71.79302607
25STK161.77749400
26BCR1.77325711
27JAK31.75893279
28ZAP701.75597970
29WNK41.75087515
30TLK11.68215064
31CASK1.67122634
32BRSK21.65259704
33VRK11.63399261
34GRK11.62602900
35TIE11.59659601
36FRK1.59390504
37TYK21.57946414
38BCKDK1.57268606
39STK391.50287071
40TAOK31.46476733
41ACVR1B1.44976696
42BMPR1B1.41741462
43SIK31.38925754
44MAPK131.34353138
45BLK1.34185166
46ERBB31.28842873
47OXSR11.25647822
48MST41.25209309
49BMPR21.21748709
50EIF2AK31.20687035
51BTK1.20186193
52NME21.14893161
53TNIK1.13579641
54ZAK1.13533436
55SRPK11.13085791
56AKT31.12601056
57SYK1.11793002
58DYRK21.10775458
59PHKG11.09033054
60PHKG21.09033054
61MATK1.08648577
62ERN11.06222196
63PKN21.05964815
64PAK31.03639683
65FER1.03392929
66NUAK11.02557820
67TGFBR11.02036652
68FGFR21.01612021
69WEE10.99128454
70MAP2K40.99052201
71PLK30.98533310
72CDK80.95995915
73IKBKE0.95642070
74NTRK30.95168972
75NEK90.95145964
76BRAF0.93021550
77PLK20.91551489
78ADRBK20.91127346
79MAP3K30.90224056
80CSNK1A1L0.89189382
81EIF2AK20.88740568
82MARK10.85657779
83CSNK1G30.84670510
84ITK0.83421086
85CSF1R0.83040415
86MAP2K60.82187999
87PRKCE0.82062610
88CSNK1G10.81677497
89CHUK0.80829315
90PBK0.78766919
91RPS6KA40.78608354
92LYN0.78243889
93CSNK1G20.77845913
94MAPKAPK50.74954482
95MAPK150.74422027
96ADRBK10.74115589
97LCK0.73604296
98IKBKB0.72474457
99TTK0.71549740
100SCYL20.70644696
101CAMKK20.69976247
102PNCK0.67453777
103ARAF0.66027927
104RPS6KA50.65001576
105OBSCN0.62338396
106MYLK0.61556125
107ATR0.60389585
108PTK60.59692612
109STK100.59519384
110PIM10.59404997
111DAPK10.58984929
112PLK40.58870432
113STK40.58722534
114MAPKAPK20.58055289
115MAP3K130.57249030
116DAPK20.56371258
117RIPK40.56327561
118BRSK10.51079374
119MAPKAPK30.50538136
120EPHA40.49964286
121PLK10.49421893
122PRKCG0.49009612
123TSSK60.48633497
124PDK20.48196564
125JAK10.47266132
126CLK10.46818433
127NEK10.46699815
128PRKCI0.46570593
129EPHA30.46388440
130STK38L0.44945956
131TAOK20.44610612
132PRKAA20.42941790
133PAK40.42791462
134TNK20.42180629
135TRPM70.41500386
136RPS6KB10.41046604
137SGK20.40077394
138MAP3K50.38969859
139PRKACA0.38486395
140YES10.38216694
141IGF1R0.37718726
142PRKCD0.37154378
143NME10.35996065
144PTK2B0.35196403
145MAP3K110.34869765
146HIPK20.34804863
147IRAK10.34560028
148MKNK20.33443633
149KSR10.32568835
150CAMK2A0.31841652
151PRKAA10.31578879
152TESK10.31368457
153PIK3CA0.31241134
154PRKCQ0.30930928
155MARK30.30862513
156CSNK1A10.30766575
157CCNB10.29585510
158STK110.28011015
159ATM0.25880542
160PKN10.25060905

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.94140069
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.95939972
3Butanoate metabolism_Homo sapiens_hsa006502.67628434
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.58899093
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.47062513
6Mismatch repair_Homo sapiens_hsa034302.33674035
7Proteasome_Homo sapiens_hsa030502.29564294
8DNA replication_Homo sapiens_hsa030302.19045201
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17146956
10Propanoate metabolism_Homo sapiens_hsa006402.14612450
11Linoleic acid metabolism_Homo sapiens_hsa005912.14367439
12Other glycan degradation_Homo sapiens_hsa005112.14252478
13Homologous recombination_Homo sapiens_hsa034402.13673404
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06669997
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.06424413
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06249498
17Primary bile acid biosynthesis_Homo sapiens_hsa001202.01460287
18Nitrogen metabolism_Homo sapiens_hsa009101.97410181
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.95813838
20Phototransduction_Homo sapiens_hsa047441.95268494
21Base excision repair_Homo sapiens_hsa034101.93026035
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.92039959
23Caffeine metabolism_Homo sapiens_hsa002321.90399655
24One carbon pool by folate_Homo sapiens_hsa006701.88880952
25Antigen processing and presentation_Homo sapiens_hsa046121.81870992
26Tryptophan metabolism_Homo sapiens_hsa003801.79061392
27N-Glycan biosynthesis_Homo sapiens_hsa005101.75346303
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73283387
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.72726059
30Measles_Homo sapiens_hsa051621.68124007
31Lysosome_Homo sapiens_hsa041421.67989744
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67698610
33Type I diabetes mellitus_Homo sapiens_hsa049401.66962073
34Legionellosis_Homo sapiens_hsa051341.63785604
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.61135334
36Chemical carcinogenesis_Homo sapiens_hsa052041.58583485
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.57339766
38Allograft rejection_Homo sapiens_hsa053301.57213715
39Leishmaniasis_Homo sapiens_hsa051401.49269390
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47908538
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46735549
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46211560
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.45991890
44Retinol metabolism_Homo sapiens_hsa008301.43143127
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42221258
46Graft-versus-host disease_Homo sapiens_hsa053321.42185516
47Ether lipid metabolism_Homo sapiens_hsa005651.40548225
48Pyrimidine metabolism_Homo sapiens_hsa002401.39222612
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38757795
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.37433689
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34542450
52Non-homologous end-joining_Homo sapiens_hsa034501.33960920
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31796295
54Collecting duct acid secretion_Homo sapiens_hsa049661.31627347
55RNA polymerase_Homo sapiens_hsa030201.31151213
56Nicotine addiction_Homo sapiens_hsa050331.30808887
57Fatty acid degradation_Homo sapiens_hsa000711.30485538
58Sulfur metabolism_Homo sapiens_hsa009201.29581799
59Vibrio cholerae infection_Homo sapiens_hsa051101.29551984
60Selenocompound metabolism_Homo sapiens_hsa004501.26107584
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23661295
62Ribosome_Homo sapiens_hsa030101.23256704
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22520502
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19463268
65Fatty acid biosynthesis_Homo sapiens_hsa000611.19420807
66Regulation of autophagy_Homo sapiens_hsa041401.18313422
67Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18231454
68Rheumatoid arthritis_Homo sapiens_hsa053231.17315951
69ABC transporters_Homo sapiens_hsa020101.16102892
70Primary immunodeficiency_Homo sapiens_hsa053401.13829670
71Hematopoietic cell lineage_Homo sapiens_hsa046401.11931100
72Nucleotide excision repair_Homo sapiens_hsa034201.11410559
73Fatty acid metabolism_Homo sapiens_hsa012121.11066660
74RNA degradation_Homo sapiens_hsa030181.09814015
75Galactose metabolism_Homo sapiens_hsa000521.09713958
76beta-Alanine metabolism_Homo sapiens_hsa004101.09593902
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08958342
78Taste transduction_Homo sapiens_hsa047421.07685528
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06589617
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06558244
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05733477
82Herpes simplex infection_Homo sapiens_hsa051681.03393727
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03131312
84Apoptosis_Homo sapiens_hsa042101.01528912
85Phagosome_Homo sapiens_hsa041451.01096639
86Pertussis_Homo sapiens_hsa051331.00551131
87Influenza A_Homo sapiens_hsa051641.00251189
88Cell cycle_Homo sapiens_hsa041100.98710628
89Oxidative phosphorylation_Homo sapiens_hsa001900.95945106
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95248945
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90201198
92Toxoplasmosis_Homo sapiens_hsa051450.86965875
93Sulfur relay system_Homo sapiens_hsa041220.86157171
94Histidine metabolism_Homo sapiens_hsa003400.86141281
95Epstein-Barr virus infection_Homo sapiens_hsa051690.85919053
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84231127
97Fanconi anemia pathway_Homo sapiens_hsa034600.82406015
98Metabolic pathways_Homo sapiens_hsa011000.81416166
99Cardiac muscle contraction_Homo sapiens_hsa042600.80554868
100Autoimmune thyroid disease_Homo sapiens_hsa053200.79652331
101Osteoclast differentiation_Homo sapiens_hsa043800.79383269
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.78981894
103TNF signaling pathway_Homo sapiens_hsa046680.78671471
104Tuberculosis_Homo sapiens_hsa051520.76743684
105Fat digestion and absorption_Homo sapiens_hsa049750.76291810
106Parkinsons disease_Homo sapiens_hsa050120.75007258
107Insulin secretion_Homo sapiens_hsa049110.74184120
108Serotonergic synapse_Homo sapiens_hsa047260.73728149
109Hepatitis B_Homo sapiens_hsa051610.72265675
110Basal transcription factors_Homo sapiens_hsa030220.70862978
111Ovarian steroidogenesis_Homo sapiens_hsa049130.69879958
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68522330
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66811267
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65511146
115Purine metabolism_Homo sapiens_hsa002300.65102469
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64293013
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64262221
118Fatty acid elongation_Homo sapiens_hsa000620.63325034
119Olfactory transduction_Homo sapiens_hsa047400.63104627
120p53 signaling pathway_Homo sapiens_hsa041150.62945592
121Shigellosis_Homo sapiens_hsa051310.61882919
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57248378
123Spliceosome_Homo sapiens_hsa030400.57082233
124Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55587046
125Hepatitis C_Homo sapiens_hsa051600.55470798
126Pyruvate metabolism_Homo sapiens_hsa006200.55183822
127Huntingtons disease_Homo sapiens_hsa050160.54943214
128Steroid biosynthesis_Homo sapiens_hsa001000.54754856
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54538745
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.54269249
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.52226773
132Morphine addiction_Homo sapiens_hsa050320.51692285
133Viral carcinogenesis_Homo sapiens_hsa052030.51298916
134Prolactin signaling pathway_Homo sapiens_hsa049170.50555273
135Starch and sucrose metabolism_Homo sapiens_hsa005000.48885609
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48374400
137Fructose and mannose metabolism_Homo sapiens_hsa000510.47647029
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47583291
139Folate biosynthesis_Homo sapiens_hsa007900.46367310
140Alzheimers disease_Homo sapiens_hsa050100.44865929
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.44825692
142Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43820050
143B cell receptor signaling pathway_Homo sapiens_hsa046620.42749566
144T cell receptor signaling pathway_Homo sapiens_hsa046600.42741699
145Glutathione metabolism_Homo sapiens_hsa004800.42082215
146GABAergic synapse_Homo sapiens_hsa047270.41935721
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41818243
148Glycerolipid metabolism_Homo sapiens_hsa005610.41767641
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41689448
150Circadian rhythm_Homo sapiens_hsa047100.39402919
151Malaria_Homo sapiens_hsa051440.38961677
152Thyroid cancer_Homo sapiens_hsa052160.38068102
153Acute myeloid leukemia_Homo sapiens_hsa052210.37949532
154Asthma_Homo sapiens_hsa053100.36945745
155Glutamatergic synapse_Homo sapiens_hsa047240.35593709
156Tyrosine metabolism_Homo sapiens_hsa003500.34638002
157Peroxisome_Homo sapiens_hsa041460.34056443
158Arachidonic acid metabolism_Homo sapiens_hsa005900.32459497
159Mineral absorption_Homo sapiens_hsa049780.30593416
160Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30537756
161Systemic lupus erythematosus_Homo sapiens_hsa053220.30401602
162Cocaine addiction_Homo sapiens_hsa050300.28906772

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »