GALNS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)4.82182374
2Golgi transport vesicle coating (GO:0048200)4.82182374
3neutrophil activation involved in immune response (GO:0002283)4.60134844
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.58957302
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.58957302
6peptide catabolic process (GO:0043171)4.39562064
7sequestering of metal ion (GO:0051238)4.24635237
8thyroid hormone generation (GO:0006590)4.17083076
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.16367764
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.16367764
11modulation by symbiont of host immune response (GO:0052553)4.16367764
12positive regulation by symbiont of host defense response (GO:0052509)4.16367764
13modulation by symbiont of host defense response (GO:0052031)4.16367764
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.16367764
15urate metabolic process (GO:0046415)4.13389869
16respiratory burst (GO:0045730)4.04545150
17antigen processing and presentation of endogenous antigen (GO:0019883)4.03875527
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.96040470
19regulation of interferon-beta biosynthetic process (GO:0045357)3.89928038
20drug transmembrane transport (GO:0006855)3.89237255
21pentose-phosphate shunt (GO:0006098)3.87549438
22drug transport (GO:0015893)3.62008423
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.60628536
24negative regulation of cell killing (GO:0031342)3.60628536
25negative regulation of interleukin-12 production (GO:0032695)3.57694111
26aminoglycoside antibiotic metabolic process (GO:0030647)3.52441167
27NADPH regeneration (GO:0006740)3.50702235
28macrophage activation involved in immune response (GO:0002281)3.46854035
29toxin transport (GO:1901998)3.43960437
30glycoside metabolic process (GO:0016137)3.40202678
31maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.37319658
32response to peptidoglycan (GO:0032494)3.35592054
33negative regulation of interleukin-6 production (GO:0032715)3.34902488
34Arp2/3 complex-mediated actin nucleation (GO:0034314)3.32961255
35reactive oxygen species biosynthetic process (GO:1903409)3.27122864
36signal peptide processing (GO:0006465)3.26326328
37detection of molecule of bacterial origin (GO:0032490)3.26265092
38response to fungus (GO:0009620)3.25694565
39leukocyte migration involved in inflammatory response (GO:0002523)3.25270081
40cellular response to zinc ion (GO:0071294)3.24178323
41positive regulation of interferon-alpha production (GO:0032727)3.23074265
42leukocyte aggregation (GO:0070486)3.21532843
43detection of other organism (GO:0098543)3.21386533
44positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.19811432
45regulation of B cell receptor signaling pathway (GO:0050855)3.17806240
46neutrophil mediated immunity (GO:0002446)3.17327497
47thyroid hormone metabolic process (GO:0042403)3.17159074
48tricarboxylic acid metabolic process (GO:0072350)3.15937293
49defense response to fungus (GO:0050832)3.09196788
50immunoglobulin mediated immune response (GO:0016064)3.08402165
51regulation of mast cell degranulation (GO:0043304)3.08004139
52detection of bacterium (GO:0016045)3.06903369
53regulation of interferon-alpha production (GO:0032647)3.04139189
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.03462883
55regulation of leukocyte degranulation (GO:0043300)3.03191293
56detection of external biotic stimulus (GO:0098581)3.03071840
57protein retention in ER lumen (GO:0006621)3.00926354
58hydrogen peroxide biosynthetic process (GO:0050665)2.99005140
59tolerance induction (GO:0002507)2.97936412
60retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.97297062
61negative regulation of interleukin-8 production (GO:0032717)2.96697775
62positive regulation of gamma-delta T cell activation (GO:0046645)2.96177435
63leukotriene metabolic process (GO:0006691)2.96116264
64neutrophil activation (GO:0042119)2.94483998
65regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.93978980
66positive regulation of Cdc42 GTPase activity (GO:0043089)2.93677594
67cilium or flagellum-dependent cell motility (GO:0001539)2.91326914
68germinal center formation (GO:0002467)2.90112274
69mannose metabolic process (GO:0006013)2.90024363
70negative regulation of phagocytosis (GO:0050765)2.88571605
71negative regulation of interleukin-1 production (GO:0032692)2.88405330
72regulation of myeloid leukocyte mediated immunity (GO:0002886)2.87764685
73response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.84073001
74response to host immune response (GO:0052572)2.84073001
75axonemal dynein complex assembly (GO:0070286)2.83787050
76killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.83485490
77disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.83485490
78granulocyte activation (GO:0036230)2.81369409
79hydrogen peroxide catabolic process (GO:0042744)2.80876019
80amino sugar catabolic process (GO:0046348)2.80865602
81response to muramyl dipeptide (GO:0032495)2.80756904
82myeloid cell activation involved in immune response (GO:0002275)2.80723684
83L-alpha-amino acid transmembrane transport (GO:1902475)2.80679570
84regulation of interleukin-6 biosynthetic process (GO:0045408)2.80577393
85production of molecular mediator involved in inflammatory response (GO:0002532)2.79312146
86lysine metabolic process (GO:0006553)2.79061331
87lysine catabolic process (GO:0006554)2.79061331
88antigen processing and presentation via MHC class Ib (GO:0002475)2.78896733
89regulation of growth of symbiont in host (GO:0044126)2.78240696
90negative regulation of growth of symbiont in host (GO:0044130)2.78240696
91negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.78240696
92modulation of growth of symbiont involved in interaction with host (GO:0044144)2.78240696
93regulation of mast cell activation involved in immune response (GO:0033006)2.77866215
94lipopolysaccharide-mediated signaling pathway (GO:0031663)2.76663497
95organic cation transport (GO:0015695)2.75644559
96negative regulation of tumor necrosis factor production (GO:0032720)2.75606481
97glucose catabolic process (GO:0006007)2.75179069
98regulation of T-helper 2 cell differentiation (GO:0045628)2.72139929
99negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.71077054
100cytidine metabolic process (GO:0046087)2.68521322
101cytidine catabolic process (GO:0006216)2.68521322
102cytidine deamination (GO:0009972)2.68521322
103negative regulation of lymphocyte mediated immunity (GO:0002707)2.65789453
104regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.65407418
105positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.64660714
106response to thyroid hormone (GO:0097066)2.63534004
107response to type I interferon (GO:0034340)2.63364934
108pyrimidine ribonucleoside catabolic process (GO:0046133)2.62228831
109response to host (GO:0075136)2.60627613
110response to host defenses (GO:0052200)2.60627613
111response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.60627613
112cellular response to exogenous dsRNA (GO:0071360)2.60235608
113leukocyte mediated cytotoxicity (GO:0001909)2.60105485
114leukotriene biosynthetic process (GO:0019370)2.59386259
115detection of biotic stimulus (GO:0009595)2.58980951
116angiogenesis involved in wound healing (GO:0060055)2.57115209
117amyloid precursor protein catabolic process (GO:0042987)2.56962071
118actin nucleation (GO:0045010)2.55564752
119fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.55129935
120leukocyte cell-cell adhesion (GO:0007159)2.55106293
121pinocytosis (GO:0006907)2.55076506
122regulation of mast cell activation (GO:0033003)2.54920228
123type I interferon signaling pathway (GO:0060337)2.53810116
124cellular response to type I interferon (GO:0071357)2.53810116
125negative regulation of leukocyte mediated immunity (GO:0002704)2.52402309
126N-acetylneuraminate metabolic process (GO:0006054)2.51915159
127cellular response to vitamin D (GO:0071305)2.51526831
128motile cilium assembly (GO:0044458)2.51336825
129NIK/NF-kappaB signaling (GO:0038061)2.51254131
130positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.51088636
131apoptotic cell clearance (GO:0043277)2.50658785
132bone resorption (GO:0045453)2.50185450
133positive regulation of histone deacetylation (GO:0031065)2.49898453
134beta-amyloid metabolic process (GO:0050435)2.49746387
135cellular extravasation (GO:0045123)2.46831112
136regulation of gamma-delta T cell activation (GO:0046643)2.46809757
137positive regulation of mast cell activation (GO:0033005)2.46410693
138regulation of regulated secretory pathway (GO:1903305)2.46224126
139negative regulation of innate immune response (GO:0045824)2.46204858
140lysosome organization (GO:0007040)2.46076302
141lytic vacuole organization (GO:0080171)2.46076302
142activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.45285284
143positive regulation of leukocyte degranulation (GO:0043302)2.45063761
144regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.44844254
145positive regulation of nuclease activity (GO:0032075)2.44536214
146macrophage activation (GO:0042116)2.43803604
147NADP metabolic process (GO:0006739)2.42489867
148regulation of type I interferon-mediated signaling pathway (GO:0060338)2.40930675
149negative regulation of bone resorption (GO:0045779)2.40688481
150positive regulation of lamellipodium assembly (GO:0010592)2.40321355
151regulation of tolerance induction (GO:0002643)2.39847259
152positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.39187593
153positive regulation of B cell differentiation (GO:0045579)2.38820450
154negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.38565723
155positive regulation of T cell mediated cytotoxicity (GO:0001916)2.38047893
156regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.37703384
157negative regulation of interleukin-1 beta production (GO:0032691)2.37063804
158endosome to melanosome transport (GO:0035646)2.36167052
159endosome to pigment granule transport (GO:0043485)2.36167052
160positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.36089773
161regulation of T cell mediated cytotoxicity (GO:0001914)2.35188639
162positive regulation of mast cell degranulation (GO:0043306)2.33370144
163positive regulation of mast cell activation involved in immune response (GO:0033008)2.33370144
164negative regulation of cytokine production involved in immune response (GO:0002719)2.32925991
165interferon-gamma secretion (GO:0072643)2.31611097
166regulation of interleukin-6 production (GO:0032675)2.31154169
167regulation of tumor necrosis factor production (GO:0032680)2.30616719
168defense response to protozoan (GO:0042832)2.29637608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.62416691
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.74651069
3E2F7_22180533_ChIP-Seq_HELA_Human3.30563585
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.06458431
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.03763500
6MYB_21317192_ChIP-Seq_ERMYB_Mouse2.98155101
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.73922349
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71199927
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.68123205
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.67784472
11VDR_21846776_ChIP-Seq_THP-1_Human2.48809277
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.42333676
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35638434
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.35422229
15BRD4_27068464_Chip-Seq_AML-cells_Mouse2.27902275
16MYC_22102868_ChIP-Seq_BL_Human2.25614551
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.19675791
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.18833944
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15454503
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.14453769
21SPI1_23547873_ChIP-Seq_NB4_Human2.08733730
22ESR2_21235772_ChIP-Seq_MCF-7_Human2.08109902
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05478055
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.99431098
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99026371
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95474616
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.92483840
28VDR_24763502_ChIP-Seq_THP-1_Human1.91209005
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89623460
30SCL_19346495_ChIP-Seq_HPC-7_Human1.81809844
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.81483963
32* RUNX1_22412390_ChIP-Seq_EML_Mouse1.80485946
33MAF_26560356_Chip-Seq_TH1_Human1.79570681
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79508440
35P68_20966046_ChIP-Seq_HELA_Human1.77908936
36PPARA_22158963_ChIP-Seq_LIVER_Mouse1.74784995
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74077290
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73923592
39GATA1_22025678_ChIP-Seq_K562_Human1.70949181
40SPI1_23127762_ChIP-Seq_K562_Human1.70895615
41MYB_26560356_Chip-Seq_TH2_Human1.69925233
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.68617792
43* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68094251
44BCL6_27268052_Chip-Seq_Bcells_Human1.67188848
45BCOR_27268052_Chip-Seq_Bcells_Human1.66352548
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66167120
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66037553
48TFEB_21752829_ChIP-Seq_HELA_Human1.63153451
49UTX_26944678_Chip-Seq_JUKART_Human1.63004755
50* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61813798
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.58547300
52MYB_26560356_Chip-Seq_TH1_Human1.56507391
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.53754491
54SMC4_20622854_ChIP-Seq_HELA_Human1.48650357
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47201792
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46465202
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.46439916
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46221747
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43784659
60TCF7_22412390_ChIP-Seq_EML_Mouse1.42710188
61LXR_22292898_ChIP-Seq_THP-1_Human1.42021563
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.40984571
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40019470
64PU_27001747_Chip-Seq_BMDM_Mouse1.37639530
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.37126514
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36770115
67TP53_22127205_ChIP-Seq_IMR90_Human1.36225846
68* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34902800
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.34143659
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34126536
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34016291
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33953694
73E2F1_20622854_ChIP-Seq_HELA_Human1.33884419
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.32315786
75RUNX1_27514584_Chip-Seq_MCF-7_Human1.31569667
76PHF8_20622854_ChIP-Seq_HELA_Human1.30844513
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27336033
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27102210
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26171564
80P63_26484246_Chip-Seq_KERATINOCYTES_Human1.25484531
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25104002
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24977029
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24654133
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22942341
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22442181
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.22134852
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22094640
88KDM2B_26808549_Chip-Seq_K562_Human1.21593105
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21072715
90LXR_22158963_ChIP-Seq_LIVER_Mouse1.20765235
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19141486
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19096969
93FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18813519
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17886626
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16935579
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16781863
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.16404729
98* TP63_22573176_ChIP-Seq_HFKS_Human1.16219615
99RARB_24833708_ChIP-Seq_LIVER_Mouse1.14935716
100IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14610779
101* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13385006
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13345673
103GATA3_27048872_Chip-Seq_THYMUS_Human1.13111095
104CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11894399
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11056397
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10729680
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10690598
108KDM2B_26808549_Chip-Seq_JURKAT_Human1.10674805
109VDR_24787735_ChIP-Seq_THP-1_Human1.10120979
110CLOCK_20551151_ChIP-Seq_293T_Human1.09686579
111EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08383818
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07754400
113RACK7_27058665_Chip-Seq_MCF-7_Human1.06893355
114* GATA1_19941827_ChIP-Seq_MEL_Mouse1.06575953
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03158861
116HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02544934
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00886258
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00823487
119LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00766341
120DROSHA_22980978_ChIP-Seq_HELA_Human0.99778191
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99272935
122* GATA3_26560356_Chip-Seq_TH2_Human0.99115123
123P300_27268052_Chip-Seq_Bcells_Human0.99034787
124SA1_27219007_Chip-Seq_Bcells_Human0.98764823
125CTCF_26484167_Chip-Seq_Bcells_Mouse0.98706392
126MAF_26560356_Chip-Seq_TH2_Human0.98291700
127CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98149900
128GATA1_19941826_ChIP-Seq_K562_Human0.98010172
129HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97927493
130CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97150283
131THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96485466
132RUNX_20019798_ChIP-Seq_JUKART_Human0.95996631
133KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94591768
134CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94439901
135KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93445136
136KDM2B_26808549_Chip-Seq_DND41_Human0.92054673
137KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92016974
138FOXM1_23109430_ChIP-Seq_U2OS_Human0.91919784
139HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90059107
140PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89494594
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.89448078

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.01749523
2MP0003436_decreased_susceptibility_to2.96612461
3MP0001835_abnormal_antigen_presentation2.84588392
4MP0003303_peritoneal_inflammation2.70787063
5MP0003300_gastrointestinal_ulcer2.62362178
6MP0003183_abnormal_peptide_metabolism2.59133685
7* MP0003172_abnormal_lysosome_physiology2.58172172
8MP0005360_urolithiasis2.40813133
9MP0006054_spinal_hemorrhage2.38870052
10MP0002419_abnormal_innate_immunity2.33037374
11MP0004043_abnormal_pH_regulation2.20415988
12MP0009785_altered_susceptibility_to2.17496490
13MP0008260_abnormal_autophagy2.15224653
14MP0003191_abnormal_cellular_cholesterol2.07980244
15MP0003705_abnormal_hypodermis_morpholog2.06215455
16MP0005387_immune_system_phenotype2.02690940
17MP0001790_abnormal_immune_system2.02690940
18MP0005000_abnormal_immune_tolerance2.01275705
19MP0000685_abnormal_immune_system2.00860343
20* MP0009643_abnormal_urine_homeostasis2.00705008
21MP0002877_abnormal_melanocyte_morpholog2.00700390
22MP0005025_abnormal_response_to1.93762072
23MP0005464_abnormal_platelet_physiology1.84630111
24MP0002452_abnormal_antigen_presenting1.83834295
25MP0002138_abnormal_hepatobiliary_system1.80626271
26MP0009840_abnormal_foam_cell1.75790051
27MP0003279_aneurysm1.75047840
28MP0001800_abnormal_humoral_immune1.72094944
29MP0002148_abnormal_hypersensitivity_rea1.68948461
30MP0001533_abnormal_skeleton_physiology1.68788310
31MP0001845_abnormal_inflammatory_respons1.66409105
32MP0002420_abnormal_adaptive_immunity1.64140647
33MP0001819_abnormal_immune_cell1.64115209
34MP0002723_abnormal_immune_serum1.64114026
35MP0003195_calcinosis1.61874285
36MP0006082_CNS_inflammation1.59683238
37MP0003566_abnormal_cell_adhesion1.58370831
38MP0002139_abnormal_hepatobiliary_system1.58326254
39MP0005451_abnormal_body_composition1.57933398
40MP0003724_increased_susceptibility_to1.57092449
41MP0002136_abnormal_kidney_physiology1.53389150
42MP0008875_abnormal_xenobiotic_pharmacok1.52294936
43MP0005671_abnormal_response_to1.48562863
44MP0005083_abnormal_biliary_tract1.47959964
45MP0008469_abnormal_protein_level1.44374842
46MP0001765_abnormal_ion_homeostasis1.44314269
47MP0001849_ear_inflammation1.42030106
48MP0001958_emphysema1.41980414
49MP0005636_abnormal_mineral_homeostasis1.39580109
50MP0001756_abnormal_urination1.39486058
51MP0005332_abnormal_amino_acid1.38968656
52MP0002405_respiratory_system_inflammati1.38707962
53MP0002653_abnormal_ependyma_morphology1.38085064
54MP0004947_skin_inflammation1.37859661
55MP0009333_abnormal_splenocyte_physiolog1.36255853
56MP0002254_reproductive_system_inflammat1.35385191
57MP0002132_abnormal_respiratory_system1.33084947
58MP0004019_abnormal_vitamin_homeostasis1.32333305
59MP0000858_altered_metastatic_potential1.32090104
60MP0004264_abnormal_extraembryonic_tissu1.30535441
61MP0005164_abnormal_response_to1.30507435
62MP0000716_abnormal_immune_system1.28569754
63MP0000343_altered_response_to1.28276301
64MP0010155_abnormal_intestine_physiology1.27116648
65MP0002998_abnormal_bone_remodeling1.27090971
66MP0005390_skeleton_phenotype1.26834406
67MP0000689_abnormal_spleen_morphology1.26605459
68MP0005310_abnormal_salivary_gland1.26536394
69MP0002398_abnormal_bone_marrow1.26049552
70MP0002396_abnormal_hematopoietic_system1.25396020
71MP0003186_abnormal_redox_activity1.24154135
72MP0002166_altered_tumor_susceptibility1.22431676
73MP0001542_abnormal_bone_strength1.21090824
74MP0000604_amyloidosis1.20618306
75MP0004883_abnormal_blood_vessel1.19533425
76MP0002429_abnormal_blood_cell1.17523150
77MP0000681_abnormal_thyroid_gland1.16655203
78MP0002722_abnormal_immune_system1.14668944
79MP0010386_abnormal_urinary_bladder1.14484312
80MP0009278_abnormal_bone_marrow1.14312096
81MP0001986_abnormal_taste_sensitivity1.13414481
82MP0004381_abnormal_hair_follicle1.13172246
83MP0003453_abnormal_keratinocyte_physiol1.12998487
84MP0003091_abnormal_cell_migration1.12990164
85MP0003828_pulmonary_edema1.11184556
86MP0003075_altered_response_to1.10572746
87MP0010307_abnormal_tumor_latency1.07799847
88MP0003763_abnormal_thymus_physiology1.07602309
89MP0000490_abnormal_crypts_of1.07297085
90MP0008438_abnormal_cutaneous_collagen1.06181585
91MP0002933_joint_inflammation1.05016728
92MP0005174_abnormal_tail_pigmentation1.04831344
93MP0000015_abnormal_ear_pigmentation1.03439611
94MP0003448_altered_tumor_morphology1.03144690
95MP0003656_abnormal_erythrocyte_physiolo1.02420009
96MP0005584_abnormal_enzyme/coenzyme_acti1.02109948
97MP0003795_abnormal_bone_structure1.01036852
98MP0005377_hearing/vestibular/ear_phenot0.98046603
99MP0003878_abnormal_ear_physiology0.98046603
100MP0005319_abnormal_enzyme/_coenzyme0.97261028
101MP0005076_abnormal_cell_differentiation0.96828967
102MP0003866_abnormal_defecation0.95696136
103MP0009764_decreased_sensitivity_to0.95425206
104MP0004858_abnormal_nervous_system0.94603194
105MP0004510_myositis0.93954214
106MP0000609_abnormal_liver_physiology0.91945764
107MP0000678_abnormal_parathyroid_gland0.89508462
108MP0005257_abnormal_intraocular_pressure0.89225893
109MP0005397_hematopoietic_system_phenotyp0.89207897
110MP0001545_abnormal_hematopoietic_system0.89207897
111MP0000465_gastrointestinal_hemorrhage0.88924960
112MP0005023_abnormal_wound_healing0.88839715
113MP0002135_abnormal_kidney_morphology0.88426143
114MP0003329_amyloid_beta_deposits0.87011099
115MP0000569_abnormal_digit_pigmentation0.86416726
116MP0009384_cardiac_valve_regurgitation0.85943867
117MP0002693_abnormal_pancreas_physiology0.84615404
118MP0004808_abnormal_hematopoietic_stem0.83762812
119MP0000598_abnormal_liver_morphology0.82861947
120MP0002928_abnormal_bile_duct0.82519932
121MP0000371_diluted_coat_color0.82419016
122MP0010352_gastrointestinal_tract_polyps0.81908625
123MP0000249_abnormal_blood_vessel0.81344885
124MP0001853_heart_inflammation0.80985562
125MP0001663_abnormal_digestive_system0.80355945
126MP0009763_increased_sensitivity_to0.79153004
127MP0000767_abnormal_smooth_muscle0.78937715
128MP0001873_stomach_inflammation0.78792742
129MP0005166_decreased_susceptibility_to0.78236133
130MP0000538_abnormal_urinary_bladder0.77850400
131MP0002168_other_aberrant_phenotype0.76191107
132MP0001348_abnormal_lacrimal_gland0.76064617
133MP0004233_abnormal_muscle_weight0.72147187
134MP0005381_digestive/alimentary_phenotyp0.70881647
135MP0000470_abnormal_stomach_morphology0.69882070

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)5.57252951
2Dysostosis multiplex (HP:0000943)4.76078274
3Eczematoid dermatitis (HP:0000976)4.50529521
4Recurrent abscess formation (HP:0002722)4.46429633
5* Urinary glycosaminoglycan excretion (HP:0003541)4.14883856
6* Mucopolysacchariduria (HP:0008155)4.14883856
7Recurrent bacterial skin infections (HP:0005406)4.07858865
8Abnormality of macrophages (HP:0004311)3.94244217
9* Abnormality of mucopolysaccharide metabolism (HP:0011020)3.84253318
10* Abnormality of polysaccharide metabolism (HP:0011012)3.84253318
11* Abnormality of glycosaminoglycan metabolism (HP:0004371)3.84253318
12Increased cerebral lipofuscin (HP:0011813)3.69816429
13Recurrent gram-negative bacterial infections (HP:0005420)3.61230273
14Nasal polyposis (HP:0100582)3.60209971
15Abnormality of the nasal mucosa (HP:0000433)3.48898750
16Hyperactive renin-angiotensin system (HP:0000841)3.45485517
17Orchitis (HP:0100796)3.44850225
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.14850386
19Stomatitis (HP:0010280)3.13816593
20Tetany (HP:0001281)3.09647615
21Abnormality of glycolipid metabolism (HP:0010969)3.06635093
22Abnormality of liposaccharide metabolism (HP:0010968)3.06635093
23Abnormality of glycosphingolipid metabolism (HP:0004343)3.06635093
24IgM deficiency (HP:0002850)3.03492611
25Hypokalemic alkalosis (HP:0001949)2.96815314
26Thin bony cortex (HP:0002753)2.94987784
27Retrobulbar optic neuritis (HP:0100654)2.94838838
28Optic neuritis (HP:0100653)2.94838838
29Autoimmune thrombocytopenia (HP:0001973)2.92428516
30Abnormality of chloride homeostasis (HP:0011422)2.88687307
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.84487175
32Absent/shortened dynein arms (HP:0200106)2.84487175
33Abnormal respiratory epithelium morphology (HP:0012253)2.81477926
34Abnormal respiratory motile cilium morphology (HP:0005938)2.81477926
35Gout (HP:0001997)2.80624561
36Abnormality of purine metabolism (HP:0004352)2.80290825
37Joint stiffness (HP:0001387)2.79638338
38Thrombocytosis (HP:0001894)2.75623647
39Generalized aminoaciduria (HP:0002909)2.74219569
40Axonal loss (HP:0003447)2.71259535
41Interstitial pulmonary disease (HP:0006530)2.63687636
42Systemic lupus erythematosus (HP:0002725)2.59872386
43Peritonitis (HP:0002586)2.59028107
44J-shaped sella turcica (HP:0002680)2.56254482
45Gingivitis (HP:0000230)2.55341822
46Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.52563832
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.52447844
48Gastrointestinal infarctions (HP:0005244)2.52383185
49Recurrent cutaneous fungal infections (HP:0011370)2.51909993
50Chronic mucocutaneous candidiasis (HP:0002728)2.51909993
51Increased circulating renin level (HP:0000848)2.49906066
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.45465970
53Polyuria (HP:0000103)2.43542559
54Increased serum ferritin (HP:0003281)2.43541010
55Abnormal ciliary motility (HP:0012262)2.40701656
56Vertebral compression fractures (HP:0002953)2.36154122
57Recurrent skin infections (HP:0001581)2.34645120
58Chronic obstructive pulmonary disease (HP:0006510)2.33597964
59Obstructive lung disease (HP:0006536)2.33597964
60Petechiae (HP:0000967)2.32047842
61Pustule (HP:0200039)2.29866700
62Myositis (HP:0100614)2.28388356
63Cellulitis (HP:0100658)2.27699028
64Abnormal urine output (HP:0012590)2.27423832
65Recurrent fungal infections (HP:0002841)2.26259488
66Metabolic alkalosis (HP:0200114)2.24608979
67Abnormal respiratory motile cilium physiology (HP:0012261)2.24198481
68Elevated erythrocyte sedimentation rate (HP:0003565)2.23092040
69Hydroxyprolinuria (HP:0003080)2.21792522
70Abnormality of proline metabolism (HP:0010907)2.21792522
71Loss of speech (HP:0002371)2.20967401
72Hemorrhage of the eye (HP:0011885)2.20613636
73Abnormality of renin-angiotensin system (HP:0000847)2.20517916
74Premature rupture of membranes (HP:0001788)2.19717939
75Abnormal platelet function (HP:0011869)2.19265217
76Impaired platelet aggregation (HP:0003540)2.19265217
77Abnormality of renal excretion (HP:0011036)2.18358700
78Long toe (HP:0010511)2.18194037
79Mediastinal lymphadenopathy (HP:0100721)2.17004273
80Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.16961695
81Severe short stature (HP:0003510)2.16380743
82Osteomyelitis (HP:0002754)2.15142772
83Proximal tubulopathy (HP:0000114)2.14762387
84Recurrent viral infections (HP:0004429)2.13684907
85Periodontitis (HP:0000704)2.13230729
86Cerebral aneurysm (HP:0004944)2.12735611
87Ketoacidosis (HP:0001993)2.08871629
88Abnormality of nucleobase metabolism (HP:0010932)2.08251325
89Spondylolisthesis (HP:0003302)2.08048767
90Prolonged neonatal jaundice (HP:0006579)2.07219878
91Hypomagnesemia (HP:0002917)2.04000965
92Hemoptysis (HP:0002105)2.02875291
93Hyperuricemia (HP:0002149)2.01873729
94Increased purine levels (HP:0004368)2.01873729
95Metaphyseal cupping (HP:0003021)2.01375886
96Pathologic fracture (HP:0002756)2.00991064
97Tetraparesis (HP:0002273)1.98452975
98Abnormality of iron homeostasis (HP:0011031)1.98446838
99Distal upper limb amyotrophy (HP:0007149)1.97449601
100Upper limb amyotrophy (HP:0009129)1.97449601
101Broad face (HP:0000283)1.97311718
102Abnormality of magnesium homeostasis (HP:0004921)1.96913265
103Cheilitis (HP:0100825)1.96535070
104Hypophosphatemia (HP:0002148)1.96476586
105Hand muscle atrophy (HP:0009130)1.95765382
106Asymmetric septal hypertrophy (HP:0001670)1.95553101
107Urticaria (HP:0001025)1.94438310
108Protrusio acetabuli (HP:0003179)1.94149672
109Chronic otitis media (HP:0000389)1.93765373
110Hyperaldosteronism (HP:0000859)1.93380437
111Renal salt wasting (HP:0000127)1.92666489
112Late onset (HP:0003584)1.92097117
113Abnormal drinking behavior (HP:0030082)1.91431153
114Polydipsia (HP:0001959)1.91431153
115Abnormality of alkaline phosphatase activity (HP:0004379)1.90923997
116Progressive neurologic deterioration (HP:0002344)1.89971656
117Persistence of primary teeth (HP:0006335)1.89776263
118Abnormal enzyme/coenzyme activity (HP:0012379)1.89450071
119Thoracic kyphosis (HP:0002942)1.89325850
120Meningitis (HP:0001287)1.89278589
121Alkalosis (HP:0001948)1.88094059
122Amyloidosis (HP:0011034)1.86790077
123Stridor (HP:0010307)1.85836004
124Elevated alkaline phosphatase (HP:0003155)1.84125821
125Joint hemorrhage (HP:0005261)1.81214271
126Inflammation of the large intestine (HP:0002037)1.81110322
127Episodic fever (HP:0001954)1.80967202
128Goiter (HP:0000853)1.80861345
129Cardiomegaly (HP:0001640)1.80463657
130Beaking of vertebral bodies (HP:0004568)1.80399628
131Absent frontal sinuses (HP:0002688)1.79871592
132Hypochromic anemia (HP:0001931)1.79791640
133Gastrointestinal inflammation (HP:0004386)1.78403837
134Nausea (HP:0002018)1.78332802
135Hypokalemia (HP:0002900)1.77288920
136Basal ganglia calcification (HP:0002135)1.77172251
137Vasculitis (HP:0002633)1.76972526
138Global brain atrophy (HP:0002283)1.76519364
139Hypoglycemic coma (HP:0001325)1.76039191
140Genu recurvatum (HP:0002816)1.75698130
141Easy fatigability (HP:0003388)1.75180917
142Pulmonary infiltrates (HP:0002113)1.74737772
143Hyperphosphatemia (HP:0002905)1.73429334
144Abnormality of transition element cation homeostasis (HP:0011030)1.72736562
145Abnormality of the thoracic spine (HP:0100711)1.72498482
146Abnormal delayed hypersensitivity skin test (HP:0002963)1.72486169
147Keratoconjunctivitis sicca (HP:0001097)1.72445529
148Deformed sella turcica (HP:0002681)1.69875340
149Abnormality of the pericardium (HP:0001697)1.69644204
150Encephalitis (HP:0002383)1.68928107
151Short nail (HP:0001799)1.68675388
152Increased IgE level (HP:0003212)1.67477722
153Emphysema (HP:0002097)1.67259459
154Keratoconjunctivitis (HP:0001096)1.65630790
155Anorexia (HP:0002039)1.65339262
156Rhinitis (HP:0012384)1.65182304
157Purpura (HP:0000979)1.65047729
158Nuclear cataract (HP:0100018)1.64620506
159Bronchiectasis (HP:0002110)1.63757448
160Testicular atrophy (HP:0000029)1.63716627
161Mesangial abnormality (HP:0001966)1.62595209

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.44093031
2TRIB33.43254719
3IRAK42.91229232
4MAP4K12.78982049
5BLK2.48023438
6MAPK152.36863384
7PKN22.27113619
8TYK22.24601831
9KIT2.14581737
10TBK12.12742717
11IRAK32.06841584
12TAOK32.06810263
13WNK41.93947366
14MAP3K111.90896124
15LRRK21.87003157
16EPHB11.78689331
17BTK1.77676216
18ZAP701.76083040
19STK101.74209679
20PRKD21.73199141
21MAP3K141.71344093
22RIPK41.68101204
23SCYL21.67688188
24NME21.67119972
25GRK61.63109604
26CDC42BPA1.60496357
27RPS6KA41.58976385
28WNK31.58418751
29JAK31.56342296
30MAP2K31.55763280
31MAP3K101.54711767
32JAK11.52965815
33TNK21.51233022
34SIK31.49677101
35PTK61.42080962
36PAK41.41502956
37EPHA21.40860973
38FLT31.40027493
39TAOK11.39349020
40SYK1.31653528
41FGFR41.30666463
42PRPF4B1.28517977
43EEF2K1.26293384
44CSK1.24092994
45TEC1.23920404
46TGFBR21.17704390
47SIK21.15097894
48PASK1.14691974
49TTN1.14430051
50TESK11.13876935
51ICK1.13764357
52TAOK21.13074865
53HCK1.11825160
54MARK21.10400041
55STK381.07246853
56RIPK11.06883296
57MAP3K61.06352229
58IKBKE1.06137371
59ITK1.04807014
60MAPKAPK31.04732971
61NEK91.04581965
62CSF1R1.03241401
63BCKDK1.00761936
64FES0.96123953
65MST40.95111239
66SMG10.93449844
67PIM10.92834632
68TRPM70.88894610
69PIM20.87718504
70PTK2B0.87449555
71JAK20.86481238
72LYN0.86106708
73GRK70.85637699
74ADRBK20.84052130
75MST1R0.83822659
76MAP3K30.82019410
77LCK0.81133848
78MAP3K70.80783926
79HIPK20.75440950
80KDR0.74890495
81EIF2AK30.74268794
82MUSK0.74033292
83MAP3K80.73285560
84MAP2K60.72295768
85NEK20.72080483
86ACVR1B0.70486345
87FGR0.70377895
88IKBKB0.68179689
89FRK0.65878575
90EPHA30.65833476
91IRAK10.65698604
92MATK0.65197392
93PTK20.64603672
94RPS6KA20.64322553
95TESK20.63768339
96RPS6KA60.63094759
97DYRK1B0.62306807
98CLK10.62294078
99RPS6KL10.60874070
100RPS6KC10.60874070
101MAPK110.60853338
102BMX0.59233264
103PDPK10.58903488
104TGFBR10.58450223
105SIK10.57616863
106PRKCD0.57520901
107PIK3CG0.57314426
108LIMK10.57225417
109IRAK20.56316653
110PDK10.53807684
111ADRBK10.52827399
112MAP3K130.52096291
113MAPK70.51133611
114NEK10.50538288
115MARK30.50326349
116PRKCH0.50004820
117TXK0.49950166
118STK40.49434453
119CDK120.48688015
120ABL20.48437991
121MAP2K20.47615691
122DDR20.47038092
123CAMKK10.45968689
124CHUK0.44118610
125PRKD10.42963525
126KSR20.40947636
127PRKG20.37246097
128MAP3K10.37230241
129EGFR0.35994830
130MTOR0.35324952
131ALK0.34565586
132CAMK1D0.34134975
133ABL10.33110564
134MAPKAPK20.31174989
135ERBB30.30789527

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.93816290
2* Glycosaminoglycan degradation_Homo sapiens_hsa005313.45665370
3* Lysosome_Homo sapiens_hsa041423.25013973
4Leishmaniasis_Homo sapiens_hsa051402.37958629
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.16530395
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.13846890
7Antigen processing and presentation_Homo sapiens_hsa046121.88095854
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.80145732
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.79153192
10Osteoclast differentiation_Homo sapiens_hsa043801.73626743
11Staphylococcus aureus infection_Homo sapiens_hsa051501.73135901
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.72895536
13Tuberculosis_Homo sapiens_hsa051521.58848561
14Sulfur metabolism_Homo sapiens_hsa009201.56793472
15N-Glycan biosynthesis_Homo sapiens_hsa005101.52825879
16Legionellosis_Homo sapiens_hsa051341.52764763
17Phagosome_Homo sapiens_hsa041451.51132190
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51065413
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50271260
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.40875379
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32634919
22Carbohydrate digestion and absorption_Homo sapiens_hsa049731.32606398
23B cell receptor signaling pathway_Homo sapiens_hsa046621.32349919
24Allograft rejection_Homo sapiens_hsa053301.32267326
25Pertussis_Homo sapiens_hsa051331.32235057
26Pentose phosphate pathway_Homo sapiens_hsa000301.30762976
27Graft-versus-host disease_Homo sapiens_hsa053321.27232859
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27059690
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22458087
30Starch and sucrose metabolism_Homo sapiens_hsa005001.22002000
31Renin-angiotensin system_Homo sapiens_hsa046141.20986617
32Selenocompound metabolism_Homo sapiens_hsa004501.19082529
33Galactose metabolism_Homo sapiens_hsa000521.18825523
34Notch signaling pathway_Homo sapiens_hsa043301.15884456
35Protein export_Homo sapiens_hsa030601.14926786
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.14168160
37Measles_Homo sapiens_hsa051621.12600788
38Collecting duct acid secretion_Homo sapiens_hsa049661.12486019
39Caffeine metabolism_Homo sapiens_hsa002321.11828676
40Hematopoietic cell lineage_Homo sapiens_hsa046401.08403468
41Shigellosis_Homo sapiens_hsa051311.06740109
42Apoptosis_Homo sapiens_hsa042101.05935824
43VEGF signaling pathway_Homo sapiens_hsa043701.03864942
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02322747
45Toxoplasmosis_Homo sapiens_hsa051451.01765907
46Thyroid hormone synthesis_Homo sapiens_hsa049181.01145145
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01106957
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00280153
49Asthma_Homo sapiens_hsa053100.99815899
50Rheumatoid arthritis_Homo sapiens_hsa053230.98721625
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.98252957
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97397636
53Folate biosynthesis_Homo sapiens_hsa007900.96777689
54Bladder cancer_Homo sapiens_hsa052190.93993993
55T cell receptor signaling pathway_Homo sapiens_hsa046600.93851253
56Tryptophan metabolism_Homo sapiens_hsa003800.92255253
57Glutathione metabolism_Homo sapiens_hsa004800.92202161
58Peroxisome_Homo sapiens_hsa041460.92196638
59Fatty acid degradation_Homo sapiens_hsa000710.91439143
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.91170574
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90909687
62Vitamin digestion and absorption_Homo sapiens_hsa049770.89522081
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89419946
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87739265
65African trypanosomiasis_Homo sapiens_hsa051430.85742964
66Endocytosis_Homo sapiens_hsa041440.85579995
67Vibrio cholerae infection_Homo sapiens_hsa051100.85136437
68Influenza A_Homo sapiens_hsa051640.83927160
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82895738
70Histidine metabolism_Homo sapiens_hsa003400.81764598
71Salmonella infection_Homo sapiens_hsa051320.79563925
72Malaria_Homo sapiens_hsa051440.79254722
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79209629
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78739023
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78425974
76Viral myocarditis_Homo sapiens_hsa054160.78364493
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76707044
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76337880
79Primary immunodeficiency_Homo sapiens_hsa053400.74721506
80Fructose and mannose metabolism_Homo sapiens_hsa000510.73827572
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.73400980
82Lysine degradation_Homo sapiens_hsa003100.72663136
83Acute myeloid leukemia_Homo sapiens_hsa052210.72321713
84TNF signaling pathway_Homo sapiens_hsa046680.72157706
85Pancreatic cancer_Homo sapiens_hsa052120.71265956
86Insulin resistance_Homo sapiens_hsa049310.70962539
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70516078
88Non-small cell lung cancer_Homo sapiens_hsa052230.70435210
89Sphingolipid metabolism_Homo sapiens_hsa006000.70427873
90Carbon metabolism_Homo sapiens_hsa012000.69866246
91Hepatitis B_Homo sapiens_hsa051610.69781183
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69393458
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.68978558
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66414061
95Hepatitis C_Homo sapiens_hsa051600.65832310
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.64962489
97Butanoate metabolism_Homo sapiens_hsa006500.64407339
98Pyruvate metabolism_Homo sapiens_hsa006200.64232926
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63131784
100Prolactin signaling pathway_Homo sapiens_hsa049170.62980498
101Chronic myeloid leukemia_Homo sapiens_hsa052200.62676162
102Herpes simplex infection_Homo sapiens_hsa051680.62639700
103mTOR signaling pathway_Homo sapiens_hsa041500.62469858
104Type I diabetes mellitus_Homo sapiens_hsa049400.61918828
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.60786921
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57775980
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.57060924
108Autoimmune thyroid disease_Homo sapiens_hsa053200.55846697
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55789838
110Amoebiasis_Homo sapiens_hsa051460.54579366
111Mineral absorption_Homo sapiens_hsa049780.53381662
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.53255305
113beta-Alanine metabolism_Homo sapiens_hsa004100.53115397
114ABC transporters_Homo sapiens_hsa020100.51363946
115DNA replication_Homo sapiens_hsa030300.51192540
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50321034
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49254257
118Choline metabolism in cancer_Homo sapiens_hsa052310.48737853
119Renal cell carcinoma_Homo sapiens_hsa052110.48683258
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48622912
121Inositol phosphate metabolism_Homo sapiens_hsa005620.48616748
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47265244
123Ovarian steroidogenesis_Homo sapiens_hsa049130.46226154
124Complement and coagulation cascades_Homo sapiens_hsa046100.45783943
125Chemokine signaling pathway_Homo sapiens_hsa040620.45177348
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42725454
127GnRH signaling pathway_Homo sapiens_hsa049120.42166336
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41922142
129Dorso-ventral axis formation_Homo sapiens_hsa043200.40802247
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40703978
131Regulation of autophagy_Homo sapiens_hsa041400.40123253
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.39995518
133Platelet activation_Homo sapiens_hsa046110.39776708
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39405751
135HTLV-I infection_Homo sapiens_hsa051660.39402090
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39061556
137Epstein-Barr virus infection_Homo sapiens_hsa051690.37725677
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37618915

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