GALNT12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.81159930
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.81159930
3antigen processing and presentation of endogenous antigen (GO:0019883)5.53581768
4diterpenoid biosynthetic process (GO:0016102)5.18975576
5positive regulation of gamma-delta T cell activation (GO:0046645)4.83806743
6NIK/NF-kappaB signaling (GO:0038061)4.63242446
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.58036913
8regulation of gamma-delta T cell differentiation (GO:0045586)4.43573755
9axonemal dynein complex assembly (GO:0070286)4.30945037
10nuclear pore complex assembly (GO:0051292)4.16263536
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.14922418
12hepatocyte apoptotic process (GO:0097284)4.14792849
13intestinal absorption (GO:0050892)4.07629925
14angiotensin maturation (GO:0002003)4.07336987
15regulation of gamma-delta T cell activation (GO:0046643)3.99727809
16calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.99182316
17negative T cell selection (GO:0043383)3.99057413
18terpenoid biosynthetic process (GO:0016114)3.93452730
19negative thymic T cell selection (GO:0045060)3.92441637
20bundle of His cell to Purkinje myocyte communication (GO:0086069)3.80224306
21vitamin transmembrane transport (GO:0035461)3.78147391
22proline biosynthetic process (GO:0006561)3.77027838
23homocysteine metabolic process (GO:0050667)3.76170112
24primary alcohol catabolic process (GO:0034310)3.72772973
25regulation of T cell tolerance induction (GO:0002664)3.69716336
26regulation of B cell receptor signaling pathway (GO:0050855)3.65756758
27glycosphingolipid catabolic process (GO:0046479)3.63695622
28sulfate transmembrane transport (GO:1902358)3.58777199
29positive thymic T cell selection (GO:0045059)3.58142787
30maintenance of gastrointestinal epithelium (GO:0030277)3.54667014
31regulation of guanylate cyclase activity (GO:0031282)3.47194972
32ethanol metabolic process (GO:0006067)3.46580596
33glycolipid catabolic process (GO:0019377)3.45985854
34nuclear pore organization (GO:0006999)3.44996338
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.44549194
36negative regulation of cell killing (GO:0031342)3.44549194
37DNA unwinding involved in DNA replication (GO:0006268)3.40820145
38vitamin A metabolic process (GO:0006776)3.38699307
39ethanol oxidation (GO:0006069)3.35517136
40thymic T cell selection (GO:0045061)3.35113395
41motile cilium assembly (GO:0044458)3.33476111
42glucose 6-phosphate metabolic process (GO:0051156)3.32768978
43JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.32767592
44Arp2/3 complex-mediated actin nucleation (GO:0034314)3.30541457
45regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.29647895
46sulfate transport (GO:0008272)3.27454919
47regulation of interleukin-12 biosynthetic process (GO:0045075)3.25110163
48regulation of T cell receptor signaling pathway (GO:0050856)3.24522222
49response to interleukin-15 (GO:0070672)3.24134418
50glucuronate metabolic process (GO:0019585)3.21578555
51uronic acid metabolic process (GO:0006063)3.21578555
52NADH metabolic process (GO:0006734)3.20021794
53cellular glucuronidation (GO:0052695)3.18643924
54nucleotide-sugar biosynthetic process (GO:0009226)3.18078578
55ribosomal small subunit biogenesis (GO:0042274)3.16925345
56heterochromatin organization (GO:0070828)3.16827144
57sperm capacitation (GO:0048240)3.16658739
58B cell receptor signaling pathway (GO:0050853)3.15558077
59tight junction assembly (GO:0070830)3.12686842
60T cell selection (GO:0045058)3.10547426
61ribosomal small subunit assembly (GO:0000028)3.10426949
62epithelial cell-cell adhesion (GO:0090136)3.10167849
63transcytosis (GO:0045056)3.08740068
64regulation of B cell differentiation (GO:0045577)3.07475538
65interferon-gamma production (GO:0032609)3.06460795
66positive regulation of respiratory burst (GO:0060267)3.06114298
67regulation of translational fidelity (GO:0006450)3.05250904
68tolerance induction (GO:0002507)3.05132368
69oligosaccharide biosynthetic process (GO:0009312)3.03929135
70receptor guanylyl cyclase signaling pathway (GO:0007168)3.03033876
71myeloid dendritic cell activation (GO:0001773)3.01317555
72regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.99956517
73cilium or flagellum-dependent cell motility (GO:0001539)2.97607840
74viral life cycle (GO:0019058)2.96987238
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.96904383
76positive T cell selection (GO:0043368)2.96799338
77leukocyte aggregation (GO:0070486)2.95869861
78positive regulation of B cell differentiation (GO:0045579)2.93930837
79mitotic chromosome condensation (GO:0007076)2.93504808
80cellular protein complex disassembly (GO:0043624)2.93340158
81antigen processing and presentation via MHC class Ib (GO:0002475)2.91414749
82pyrimidine-containing compound transmembrane transport (GO:0072531)2.90845365
83COPI coating of Golgi vesicle (GO:0048205)2.89020827
84Golgi transport vesicle coating (GO:0048200)2.89020827
85midgut development (GO:0007494)2.87842811
86hormone catabolic process (GO:0042447)2.87629440
87cellular response to interleukin-15 (GO:0071350)2.86261712
88T cell receptor signaling pathway (GO:0050852)2.84920595
89translational elongation (GO:0006414)2.84858853
90lung epithelium development (GO:0060428)2.84709026
91membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.84678763
92positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.84089721
93ceramide catabolic process (GO:0046514)2.83465337
94antigen receptor-mediated signaling pathway (GO:0050851)2.83405318
95establishment of apical/basal cell polarity (GO:0035089)2.83027267
96lipoprotein transport (GO:0042953)2.82624031
97protein localization to endoplasmic reticulum (GO:0070972)2.82169669
98phenol-containing compound catabolic process (GO:0019336)2.80119536
99regulation of response to interferon-gamma (GO:0060330)2.78581900
100intestinal epithelial cell development (GO:0060576)2.78506175
101positive regulation of tolerance induction (GO:0002645)2.78204880
102response to type I interferon (GO:0034340)2.77699236
103regulation of necroptotic process (GO:0060544)2.77581295
104T cell costimulation (GO:0031295)2.77435712
105negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.76932167
106pore complex assembly (GO:0046931)2.76147184
107epithelial structure maintenance (GO:0010669)2.75453013
108glutamine family amino acid biosynthetic process (GO:0009084)2.74347989
109virion attachment to host cell (GO:0019062)2.74318821
110adhesion of symbiont to host cell (GO:0044650)2.74318821
111protein complex disassembly (GO:0043241)2.73418565
112type I interferon signaling pathway (GO:0060337)2.73257716
113cellular response to type I interferon (GO:0071357)2.73257716
114lymphocyte costimulation (GO:0031294)2.73106281
115formation of translation preinitiation complex (GO:0001731)2.73027112
116myeloid dendritic cell differentiation (GO:0043011)2.72896981
117nucleoside diphosphate biosynthetic process (GO:0009133)2.72844240
118T cell migration (GO:0072678)2.71991769
119T cell homeostasis (GO:0043029)2.71318619
120mature B cell differentiation (GO:0002335)2.70438960
121regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.69687829
122maturation of SSU-rRNA (GO:0030490)2.69304161
123viral transcription (GO:0019083)2.67675820
124regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.67465846
125translational initiation (GO:0006413)2.66969928
126membrane repolarization during action potential (GO:0086011)2.64942825
127desmosome organization (GO:0002934)2.64404161
128positive regulation of interleukin-2 production (GO:0032743)2.63852206
129proline metabolic process (GO:0006560)2.63660757
130renal system process involved in regulation of blood volume (GO:0001977)2.63510055
131positive regulation of antigen processing and presentation (GO:0002579)2.63135308
132actin nucleation (GO:0045010)2.62694787
133regulation of respiratory burst (GO:0060263)2.62051965
134regulation of tolerance induction (GO:0002643)2.61578657
135synapsis (GO:0007129)2.61260215
136urea cycle (GO:0000050)2.61194445
137negative regulation of T cell receptor signaling pathway (GO:0050860)2.58917136
138positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.58700453
139negative regulation of erythrocyte differentiation (GO:0045647)2.57955606
140retinoic acid metabolic process (GO:0042573)2.57063679
141immunoglobulin mediated immune response (GO:0016064)2.56984830
142regulation of cholesterol homeostasis (GO:2000188)2.56895507
143protein autoprocessing (GO:0016540)2.56682265
144cellular response to interferon-beta (GO:0035458)2.56107863
145cilium movement (GO:0003341)2.55369333
146* protein O-linked glycosylation (GO:0006493)2.54868768
147hematopoietic stem cell differentiation (GO:0060218)2.54706911
148translational termination (GO:0006415)2.54704769
149tumor necrosis factor-mediated signaling pathway (GO:0033209)2.54116403
150lymphocyte homeostasis (GO:0002260)2.54115841
151natural killer cell mediated cytotoxicity (GO:0042267)2.53965567
152natural killer cell mediated immunity (GO:0002228)2.53965567
153regulation of type I interferon-mediated signaling pathway (GO:0060338)2.53940394
154establishment or maintenance of apical/basal cell polarity (GO:0035088)2.53504210
155establishment or maintenance of bipolar cell polarity (GO:0061245)2.53504210
156UDP-N-acetylglucosamine metabolic process (GO:0006047)2.52948390
157macromolecular complex disassembly (GO:0032984)2.52707448
158peptide catabolic process (GO:0043171)2.52368211
159SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.51643298
160kidney morphogenesis (GO:0060993)2.51525939
161regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.50654746
162epoxygenase P450 pathway (GO:0019373)2.49822805
163negative regulation of bone resorption (GO:0045779)2.49687278
164regulation of RIG-I signaling pathway (GO:0039535)2.49557864
165necroptotic process (GO:0070266)2.48742750
166positive regulation of lamellipodium assembly (GO:0010592)2.48410116
167establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.48322407
168primary alcohol metabolic process (GO:0034308)2.47532077
169response to epidermal growth factor (GO:0070849)2.47511589
170negative regulation of glycoprotein biosynthetic process (GO:0010561)2.47093036
171regulation of interferon-beta biosynthetic process (GO:0045357)2.46732932
172leukocyte cell-cell adhesion (GO:0007159)2.46106243
173lymph node development (GO:0048535)2.45563441
174negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.44999333
175mucosal-associated lymphoid tissue development (GO:0048537)2.44971490
176Peyers patch development (GO:0048541)2.44971490
177protein targeting to ER (GO:0045047)2.44830939
178interferon-gamma-mediated signaling pathway (GO:0060333)2.44806272
179protein localization to kinetochore (GO:0034501)2.44099345
180cotranslational protein targeting to membrane (GO:0006613)2.42160777
181* O-glycan processing (GO:0016266)2.41155869
182regulation of alpha-beta T cell proliferation (GO:0046640)2.38973810
183B cell mediated immunity (GO:0019724)2.36270983
184response to protozoan (GO:0001562)2.35547233
185immune response-activating cell surface receptor signaling pathway (GO:0002429)2.33152476
186establishment of protein localization to endoplasmic reticulum (GO:0072599)2.32724774
187natural killer cell activation (GO:0030101)2.32345136

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.68322256
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.01068560
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.73668011
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.50665879
5MYC_22102868_ChIP-Seq_BL_Human3.24382505
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.19963652
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.96278452
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50228611
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.47410796
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44362001
11VDR_21846776_ChIP-Seq_THP-1_Human2.42831694
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.37964048
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.37964048
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.37964048
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.37047135
16MYB_26560356_Chip-Seq_TH2_Human2.36872937
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.32808876
18PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.32519243
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.25532149
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.22834460
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22122292
22MAF_26560356_Chip-Seq_TH1_Human2.19374054
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14690551
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14335861
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13645849
26MYB_26560356_Chip-Seq_TH1_Human2.13156070
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.03918700
28TCF7_22412390_ChIP-Seq_EML_Mouse2.01646759
29UTX_26944678_Chip-Seq_JUKART_Human1.97741749
30ZNF263_19887448_ChIP-Seq_K562_Human1.96727576
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.89498272
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.88463805
33SPI1_23547873_ChIP-Seq_NB4_Human1.88377476
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86022509
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84360992
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84019229
37VDR_24763502_ChIP-Seq_THP-1_Human1.83778708
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83291520
39RUNX_20019798_ChIP-Seq_JUKART_Human1.82328071
40* SOX2_20726797_ChIP-Seq_SW620_Human1.81427616
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81008864
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80783961
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80565503
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.78551929
45SCL_19346495_ChIP-Seq_HPC-7_Human1.77891146
46* IRF8_27001747_Chip-Seq_BMDM_Mouse1.77289840
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74563486
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74133642
49KLF4_18555785_ChIP-Seq_MESCs_Mouse1.73809961
50CLOCK_20551151_ChIP-Seq_293T_Human1.73195935
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.72672911
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68332266
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.65601963
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63509010
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63221177
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.61816754
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61075919
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59725867
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59039536
60RUNX1_27514584_Chip-Seq_MCF-7_Human1.58591197
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56992983
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54431475
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53015267
64* CHD1_26751641_Chip-Seq_LNCaP_Human1.49695276
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48696065
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47692382
67SPI1_23127762_ChIP-Seq_K562_Human1.47626823
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47569614
69GATA1_19941826_ChIP-Seq_K562_Human1.45730287
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45554802
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44890209
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44489546
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41567501
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41510050
75MAF_26560356_Chip-Seq_TH2_Human1.41400861
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39795937
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39541279
78* GATA3_27048872_Chip-Seq_THYMUS_Human1.38732609
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.38355281
80CIITA_25753668_ChIP-Seq_RAJI_Human1.36697889
81ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32726093
82TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.32573896
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31430504
84MYC_18555785_ChIP-Seq_MESCs_Mouse1.28981159
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28213299
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28069494
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27769964
88BP1_19119308_ChIP-ChIP_Hs578T_Human1.26878826
89KDM2B_26808549_Chip-Seq_DND41_Human1.26487329
90HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26312956
91MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25961681
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.25540127
93* GATA2_19941826_ChIP-Seq_K562_Human1.25421212
94E2F1_21310950_ChIP-Seq_MCF-7_Human1.25361586
95NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24830724
96* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.23640481
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21860335
98KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21386030
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21382523
100KAP1_27257070_Chip-Seq_ESCs_Mouse1.20640804
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19676530
102ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18785575
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18531647
104MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18026346
105GATA6_25053715_ChIP-Seq_YYC3_Human1.17908498
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.17616426
107GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.17226761
108TFEB_21752829_ChIP-Seq_HELA_Human1.16825080
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16222064
110E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15746040
111PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15597624
112SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15178917
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14177450
114KLF5_25053715_ChIP-Seq_YYC3_Human1.14053485
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13924547
116* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13900985
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12272130
118HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08629087
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07403057
120MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07357257
121AR_21909140_ChIP-Seq_LNCAP_Human1.07270773
122MYC_19079543_ChIP-ChIP_MESCs_Mouse1.06787539
123* GATA3_24758297_ChIP-Seq_MCF-7_Human1.04744233
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04444029
125SOX2_18692474_ChIP-Seq_MEFs_Mouse1.04110426
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03974868
127EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03819416
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03417155
129NANOG_18692474_ChIP-Seq_MEFs_Mouse1.03101808
130OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02942943
131PU_27001747_Chip-Seq_BMDM_Mouse1.02513602
132NCOR1_26117541_ChIP-Seq_K562_Human1.02265862
133GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01884805
134VDR_23849224_ChIP-Seq_CD4+_Human1.01145620
135FOXP3_21729870_ChIP-Seq_TREG_Human1.00925540
136RXR_22158963_ChIP-Seq_LIVER_Mouse1.00871840
137KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00414323
138FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00182988
139TTF2_22483619_ChIP-Seq_HELA_Human0.98676638
140XRN2_22483619_ChIP-Seq_HELA_Human0.98631914
141GATA1_22025678_ChIP-Seq_K562_Human0.98160827
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97925377
143LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97335558
144SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96139620
145* FOXA1_25552417_ChIP-Seq_VCAP_Human0.95995718
146LXR_22292898_ChIP-Seq_THP-1_Human0.95827138
147PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95693190
148ESR2_21235772_ChIP-Seq_MCF-7_Human0.94074807
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94060373
150KDM5A_27292631_Chip-Seq_BREAST_Human0.92941896
151CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92840024
152CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92723255
153CDX2_20551321_ChIP-Seq_CACO-2_Human0.91364770
154PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88699763
155CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87360627
156P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87272078
157SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86537945
158CREB1_26743006_Chip-Seq_LNCaP_Human0.86111289
159GATA1_26923725_Chip-Seq_HPCs_Mouse0.85968100
160ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85682564
161CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85125860
162ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84448430
163SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.83587816
164GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83296953
165RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82685775
166DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82296508
167NELFA_20434984_ChIP-Seq_ESCs_Mouse0.79838773
168RACK7_27058665_Chip-Seq_MCF-7_Human0.79748706
169* GATA3_26560356_Chip-Seq_TH2_Human0.79303705
170PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79149574
171ATF3_27146783_Chip-Seq_COLON_Human0.78531329
172GATA4_25053715_ChIP-Seq_YYC3_Human0.77978940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.01997767
2MP0001873_stomach_inflammation3.55545698
3MP0001835_abnormal_antigen_presentation3.38398467
4MP0000566_synostosis3.28968037
5MP0003763_abnormal_thymus_physiology3.05239998
6MP0010030_abnormal_orbit_morphology2.99760254
7MP0000685_abnormal_immune_system2.93112843
8MP0005671_abnormal_response_to2.84838576
9MP0002139_abnormal_hepatobiliary_system2.82548684
10MP0002166_altered_tumor_susceptibility2.76364577
11MP0003866_abnormal_defecation2.73803867
12MP0010155_abnormal_intestine_physiology2.70723063
13MP0010352_gastrointestinal_tract_polyps2.64300088
14MP0003300_gastrointestinal_ulcer2.59034137
15MP0001800_abnormal_humoral_immune2.57534037
16MP0010234_abnormal_vibrissa_follicle2.49005381
17MP0004147_increased_porphyrin_level2.46793330
18MP0001790_abnormal_immune_system2.45852808
19MP0005387_immune_system_phenotype2.45852808
20MP0000490_abnormal_crypts_of2.39760051
21MP0004019_abnormal_vitamin_homeostasis2.37514601
22MP0002452_abnormal_antigen_presenting2.26602711
23MP0000678_abnormal_parathyroid_gland2.22549555
24MP0010678_abnormal_skin_adnexa2.21948383
25MP0002420_abnormal_adaptive_immunity2.20283492
26MP0001819_abnormal_immune_cell2.19658385
27MP0005000_abnormal_immune_tolerance2.17559901
28MP0002006_tumorigenesis2.16888251
29MP0002723_abnormal_immune_serum2.16132071
30MP0002398_abnormal_bone_marrow2.14129468
31MP0004043_abnormal_pH_regulation2.13407886
32MP0005310_abnormal_salivary_gland2.12212649
33MP0003941_abnormal_skin_development2.08801519
34MP0009785_altered_susceptibility_to2.03458588
35MP0005365_abnormal_bile_salt1.98338231
36MP0000716_abnormal_immune_system1.91202668
37MP0009333_abnormal_splenocyte_physiolog1.90501548
38MP0002396_abnormal_hematopoietic_system1.88964590
39MP0005025_abnormal_response_to1.88322549
40MP0004947_skin_inflammation1.86613877
41MP0002796_impaired_skin_barrier1.84357850
42MP0005085_abnormal_gallbladder_physiolo1.78626194
43MP0003693_abnormal_embryo_hatching1.77796670
44MP0002722_abnormal_immune_system1.77777089
45MP0004264_abnormal_extraembryonic_tissu1.76268192
46MP0003436_decreased_susceptibility_to1.75262360
47MP0002405_respiratory_system_inflammati1.73704200
48MP0002138_abnormal_hepatobiliary_system1.72968649
49MP0000383_abnormal_hair_follicle1.72023900
50MP0000689_abnormal_spleen_morphology1.71347031
51MP0000703_abnormal_thymus_morphology1.71100936
52MP0002877_abnormal_melanocyte_morpholog1.70692475
53MP0002148_abnormal_hypersensitivity_rea1.70413951
54MP0006082_CNS_inflammation1.70256495
55MP0009840_abnormal_foam_cell1.67831661
56MP0002429_abnormal_blood_cell1.61905521
57MP0003705_abnormal_hypodermis_morpholog1.60636176
58MP0004782_abnormal_surfactant_physiolog1.60167038
59MP0000537_abnormal_urethra_morphology1.59792997
60MP0001845_abnormal_inflammatory_respons1.54452944
61MP0004808_abnormal_hematopoietic_stem1.54337643
62MP0003890_abnormal_embryonic-extraembry1.51626344
63MP0002419_abnormal_innate_immunity1.49112339
64MP0003303_peritoneal_inflammation1.48789646
65MP0000477_abnormal_intestine_morphology1.47390919
66MP0005360_urolithiasis1.46843945
67MP0000462_abnormal_digestive_system1.46377586
68MP0005464_abnormal_platelet_physiology1.43880628
69MP0010307_abnormal_tumor_latency1.42515722
70MP0001663_abnormal_digestive_system1.41786914
71MP0004510_myositis1.39908891
72MP0003183_abnormal_peptide_metabolism1.38704811
73MP0005076_abnormal_cell_differentiation1.36756026
74MP0002009_preneoplasia1.36578742
75MP0005083_abnormal_biliary_tract1.33773591
76MP0000465_gastrointestinal_hemorrhage1.30144180
77MP0010094_abnormal_chromosome_stability1.29162233
78MP0004957_abnormal_blastocyst_morpholog1.27863764
79MP0005174_abnormal_tail_pigmentation1.27414127
80MP0001730_embryonic_growth_arrest1.26497472
81MP0002098_abnormal_vibrissa_morphology1.25543679
82MP0009278_abnormal_bone_marrow1.23611498
83MP0008995_early_reproductive_senescence1.23463197
84MP0001545_abnormal_hematopoietic_system1.23354177
85MP0005397_hematopoietic_system_phenotyp1.23354177
86MP0005058_abnormal_lysosome_morphology1.19102753
87MP0008932_abnormal_embryonic_tissue1.18497740
88MP0008057_abnormal_DNA_replication1.18490180
89MP0005636_abnormal_mineral_homeostasis1.18194722
90MP0002277_abnormal_respiratory_mucosa1.17803580
91MP0000858_altered_metastatic_potential1.17777189
92MP0008007_abnormal_cellular_replicative1.17407550
93MP0005248_abnormal_Harderian_gland1.14679127
94MP0001765_abnormal_ion_homeostasis1.12718467
95MP0005501_abnormal_skin_physiology1.12080090
96MP0002019_abnormal_tumor_incidence1.11320269
97MP0002084_abnormal_developmental_patter1.10446000
98MP0006054_spinal_hemorrhage1.09689009
99MP0003724_increased_susceptibility_to1.08960899
100MP0001853_heart_inflammation1.08723197
101MP0003077_abnormal_cell_cycle1.08195480
102MP0003937_abnormal_limbs/digits/tail_de1.07865585
103MP0003453_abnormal_keratinocyte_physiol1.07735111
104MP0008004_abnormal_stomach_pH1.07698276
105MP0005381_digestive/alimentary_phenotyp1.07501485
106MP0001727_abnormal_embryo_implantation1.06966516
107MP0008875_abnormal_xenobiotic_pharmacok1.06731512
108MP0002254_reproductive_system_inflammat1.05852122
109MP0002249_abnormal_larynx_morphology1.04688665
110MP0002085_abnormal_embryonic_tissue1.01549336
111MP0005408_hypopigmentation1.01203941
112MP0001293_anophthalmia1.00810915
113MP0003718_maternal_effect1.00494611
114MP0003938_abnormal_ear_development0.99753355
115MP0001697_abnormal_embryo_size0.99135955
116MP0003191_abnormal_cellular_cholesterol0.98857926
117MP0002132_abnormal_respiratory_system0.98230325
118MP0005451_abnormal_body_composition0.95815584
119MP0001881_abnormal_mammary_gland0.94515447
120MP0001672_abnormal_embryogenesis/_devel0.93922440
121MP0005380_embryogenesis_phenotype0.93922440
122MP0002693_abnormal_pancreas_physiology0.92136943
123MP0001849_ear_inflammation0.90290466
124MP0001348_abnormal_lacrimal_gland0.89916643
125MP0003984_embryonic_growth_retardation0.89883210
126MP0003123_paternal_imprinting0.88527015
127MP0002933_joint_inflammation0.88077950
128MP0002086_abnormal_extraembryonic_tissu0.86487145
129MP0008469_abnormal_protein_level0.85838211
130MP0001666_abnormal_nutrient_absorption0.85796419
131MP0002088_abnormal_embryonic_growth/wei0.85522669
132MP0002111_abnormal_tail_morphology0.84883602
133MP0000377_abnormal_hair_follicle0.84254201
134MP0000470_abnormal_stomach_morphology0.83309167
135MP0003283_abnormal_digestive_organ0.83238766
136MP0003172_abnormal_lysosome_physiology0.82204794
137MP0008058_abnormal_DNA_repair0.82105388
138MP0000350_abnormal_cell_proliferation0.82057722
139MP0009643_abnormal_urine_homeostasis0.81423685
140MP0003868_abnormal_feces_composition0.81233738
141MP0002080_prenatal_lethality0.80792225
142MP0000013_abnormal_adipose_tissue0.80486598
143MP0000313_abnormal_cell_death0.78559234
144MP0000428_abnormal_craniofacial_morphol0.77835426
145MP0003045_fibrosis0.77048931
146MP0003119_abnormal_digestive_system0.76093288
147MP0000432_abnormal_head_morphology0.74255739
148MP0002233_abnormal_nose_morphology0.74086899
149MP0003806_abnormal_nucleotide_metabolis0.73517465
150MP0005023_abnormal_wound_healing0.71787421
151MP0001533_abnormal_skeleton_physiology0.70896943
152MP0003566_abnormal_cell_adhesion0.70454639
153MP0005257_abnormal_intraocular_pressure0.69681613
154MP0000579_abnormal_nail_morphology0.69213165
155MP0003448_altered_tumor_morphology0.67317816
156MP0009672_abnormal_birth_weight0.67114721
157MP0002092_abnormal_eye_morphology0.66809571
158MP0000609_abnormal_liver_physiology0.65828693
159MP0001346_abnormal_lacrimal_gland0.65557577
160MP0001216_abnormal_epidermal_layer0.65124792
161MP0005409_darkened_coat_color0.64600303
162MP0004185_abnormal_adipocyte_glucose0.63651668
163MP0002928_abnormal_bile_duct0.62195015
164MP0002136_abnormal_kidney_physiology0.62104864
165MP0001664_abnormal_digestion0.61779752
166MP0003111_abnormal_nucleus_morphology0.60147868
167MP0003943_abnormal_hepatobiliary_system0.59730488
168MP0002163_abnormal_gland_morphology0.59635490

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)6.70286956
2Chronic bronchitis (HP:0004469)4.90098715
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.55479195
4Recurrent viral infections (HP:0004429)4.36620338
5Recurrent fungal infections (HP:0002841)4.15607286
6Abnormality of B cell number (HP:0010975)4.11003975
7B lymphocytopenia (HP:0010976)4.11003975
8Abnormality of chloride homeostasis (HP:0011422)4.10539543
9Panhypogammaglobulinemia (HP:0003139)4.10476574
10Thyroiditis (HP:0100646)4.07096914
11T lymphocytopenia (HP:0005403)4.05020337
12Severe combined immunodeficiency (HP:0004430)3.97252747
13Flat acetabular roof (HP:0003180)3.94583736
14Abnormality of T cell number (HP:0011839)3.93831818
15Combined immunodeficiency (HP:0005387)3.83913682
16Abnormal respiratory motile cilium physiology (HP:0012261)3.77143337
17Recurrent bronchitis (HP:0002837)3.73131275
18Rhinitis (HP:0012384)3.72505390
19IgM deficiency (HP:0002850)3.71144506
20Abnormality of T cells (HP:0002843)3.67255627
21Elevated erythrocyte sedimentation rate (HP:0003565)3.66476571
22Pili torti (HP:0003777)3.62827985
23Abnormal respiratory epithelium morphology (HP:0012253)3.62682346
24Abnormal respiratory motile cilium morphology (HP:0005938)3.62682346
25Thrombocytosis (HP:0001894)3.53409735
26Abnormal ciliary motility (HP:0012262)3.49845573
27Absent/shortened dynein arms (HP:0200106)3.49826489
28Dynein arm defect of respiratory motile cilia (HP:0012255)3.49826489
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.47348873
30Pustule (HP:0200039)3.47113260
31Ankyloglossia (HP:0010296)3.39705764
32Ileus (HP:0002595)3.39129086
33Abnormality of renin-angiotensin system (HP:0000847)3.34230541
34Abnormality of T cell physiology (HP:0011840)3.32577279
35Inflammation of the large intestine (HP:0002037)3.31737966
36Decreased circulating renin level (HP:0003351)3.31204599
37Chronic otitis media (HP:0000389)3.30875996
38Chronic diarrhea (HP:0002028)3.29097993
39Gastrointestinal inflammation (HP:0004386)3.24343221
40Hyponatremia (HP:0002902)3.20793796
41Eosinophilia (HP:0001880)3.18835221
42Myositis (HP:0100614)3.16966300
43Autoimmune thrombocytopenia (HP:0001973)3.14361504
44Eczematoid dermatitis (HP:0000976)3.09345400
45Bronchiectasis (HP:0002110)3.05638960
46Colitis (HP:0002583)3.03979406
47Agammaglobulinemia (HP:0004432)3.03003801
48Hyperaldosteronism (HP:0000859)2.99775269
49Granulocytopenia (HP:0001913)2.99027079
50Recurrent cutaneous fungal infections (HP:0011370)2.98790865
51Chronic mucocutaneous candidiasis (HP:0002728)2.98790865
52Metabolic alkalosis (HP:0200114)2.97122695
53Abnormality of the fingertips (HP:0001211)2.89716381
54Right ventricular cardiomyopathy (HP:0011663)2.88419497
55IgA deficiency (HP:0002720)2.85955406
56Abnormality of eosinophils (HP:0001879)2.85432116
57Recurrent abscess formation (HP:0002722)2.84893203
58Nasal polyposis (HP:0100582)2.82008627
59Autoimmune hemolytic anemia (HP:0001890)2.79850563
60Male infertility (HP:0003251)2.78919047
61Intrahepatic cholestasis (HP:0001406)2.76637260
62Cellulitis (HP:0100658)2.75468877
63Abnormality of cells of the lymphoid lineage (HP:0012140)2.75344364
64Fatigue (HP:0012378)2.73934119
65Villous atrophy (HP:0011473)2.73297229
66Abnormality of small intestinal villus morphology (HP:0011472)2.73297229
67Hypoplasia of the thymus (HP:0000778)2.72665715
68Lymphopenia (HP:0001888)2.70861661
69Fat malabsorption (HP:0002630)2.69925771
70Recurrent bacterial skin infections (HP:0005406)2.62073523
71Biliary tract neoplasm (HP:0100574)2.57231905
72Aplasia/Hypoplasia of the sacrum (HP:0008517)2.55212436
73Leukocytosis (HP:0001974)2.55208641
74Poikiloderma (HP:0001029)2.52826081
75Abnormality of oral frenula (HP:0000190)2.51322890
76Papilloma (HP:0012740)2.51003201
77Verrucae (HP:0200043)2.51003201
78IgG deficiency (HP:0004315)2.50773200
79Abnormality of glutamine family amino acid metabolism (HP:0010902)2.49050996
80Abnormality of the distal phalanx of the thumb (HP:0009617)2.47293147
81Meningitis (HP:0001287)2.47022197
82Malnutrition (HP:0004395)2.40696633
83Truncus arteriosus (HP:0001660)2.40594975
8411 pairs of ribs (HP:0000878)2.40192759
85Vasculitis (HP:0002633)2.39388163
86Abnormality of the nasal mucosa (HP:0000433)2.39175831
87Cholecystitis (HP:0001082)2.36920987
88Abnormal gallbladder physiology (HP:0012438)2.36920987
89Macrocytic anemia (HP:0001972)2.35476669
90Hematochezia (HP:0002573)2.34654131
91Lymphoma (HP:0002665)2.33952943
92Hyperkalemia (HP:0002153)2.33006012
93Bronchitis (HP:0012387)2.32378485
94Abnormal hair laboratory examination (HP:0003328)2.31556522
95Interstitial pulmonary disease (HP:0006530)2.30642441
96Abnormality of sodium homeostasis (HP:0010931)2.28128243
97Abnormal biliary tract morphology (HP:0012440)2.27711435
98Orchitis (HP:0100796)2.25210862
99Gastrointestinal stroma tumor (HP:0100723)2.23074218
100Gout (HP:0001997)2.22830700
101Curly hair (HP:0002212)2.22813515
102Cheilitis (HP:0100825)2.21928002
103Increased IgE level (HP:0003212)2.21760605
104Steatorrhea (HP:0002570)2.21357657
105Recurrent skin infections (HP:0001581)2.21130339
106Reticulocytopenia (HP:0001896)2.21003681
107Micronodular cirrhosis (HP:0001413)2.20153256
108Focal segmental glomerulosclerosis (HP:0000097)2.19229811
109Dysostosis multiplex (HP:0000943)2.18934908
110Periodontitis (HP:0000704)2.18617816
111Abnormality of reticulocytes (HP:0004312)2.16766129
112Arterial thrombosis (HP:0004420)2.15695149
113Chromsome breakage (HP:0040012)2.12635689
114Flattened epiphyses (HP:0003071)2.12220369
115Delayed epiphyseal ossification (HP:0002663)2.08023138
116Abnormal tarsal ossification (HP:0008369)2.07249656
117Abnormality of the vitamin B12 metabolism (HP:0004341)2.06993186
118Glomerulosclerosis (HP:0000096)2.05370745
119Alkalosis (HP:0001948)2.04706101
120Protuberant abdomen (HP:0001538)2.04235922
121Renal salt wasting (HP:0000127)2.02635454
122Vertebral hypoplasia (HP:0008417)2.02387925
123Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.02387925
124Short middle phalanx of finger (HP:0005819)2.00978693
125Optic neuritis (HP:0100653)2.00333402
126Retrobulbar optic neuritis (HP:0100654)2.00333402
127Abnormality of macrophages (HP:0004311)1.99136935
128Mucopolysacchariduria (HP:0008155)1.99067496
129Urinary glycosaminoglycan excretion (HP:0003541)1.99067496
130Pulmonary infiltrates (HP:0002113)1.98846561
131Partial duplication of thumb phalanx (HP:0009944)1.98582242
132Mediastinal lymphadenopathy (HP:0100721)1.96593835
133Abnormality of vitamin metabolism (HP:0100508)1.96490331
134Hypotension (HP:0002615)1.95452510
135Esophageal varix (HP:0002040)1.94138358
136Chronic sinusitis (HP:0011109)1.93505094
137Thin bony cortex (HP:0002753)1.91419982
138Amaurosis fugax (HP:0100576)1.91277438
139Disproportionate tall stature (HP:0001519)1.90963973
140Vacuolated lymphocytes (HP:0001922)1.90708544
141Recurrent sinusitis (HP:0011108)1.90176760
142Encephalitis (HP:0002383)1.90127845
143Confusion (HP:0001289)1.89479768
144Abnormality of cells of the erythroid lineage (HP:0012130)1.89476083
145Petechiae (HP:0000967)1.89455899
146Increased IgM level (HP:0003496)1.89080878
147Abnormality of vitamin B metabolism (HP:0004340)1.87966151
148Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86687273
149Abnormality of monocarboxylic acid metabolism (HP:0010996)1.85758229
150Abnormality of the gastric mucosa (HP:0004295)1.85296967
151Malignant gastrointestinal tract tumors (HP:0006749)1.84860677
152Gastrointestinal carcinoma (HP:0002672)1.84860677
153Chest pain (HP:0100749)1.84400205
154Abnormal cartilage morphology (HP:0002763)1.82797493
155Sepsis (HP:0100806)1.82326594
156Emphysema (HP:0002097)1.82203843
157Atelectasis (HP:0100750)1.81558799
158Osteomyelitis (HP:0002754)1.81233381
159Viral hepatitis (HP:0006562)1.80929998
160Infertility (HP:0000789)1.80151171
161Neoplasm of the small intestine (HP:0100833)1.79363121
162Abnormal vertebral ossification (HP:0100569)1.79138747
163Abdominal distention (HP:0003270)1.79011148
164Hypergammaglobulinemia (HP:0010702)1.78755203
165Neoplasm of the rectum (HP:0100743)1.77442985
166Hemoptysis (HP:0002105)1.76952097
167Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76938035
168Skin ulcer (HP:0200042)1.76836953
169Rectal prolapse (HP:0002035)1.76648291
170Widely patent fontanelles and sutures (HP:0004492)1.76340969
171Duplication of thumb phalanx (HP:0009942)1.76015243
172Impaired platelet aggregation (HP:0003540)1.75249136
173Abnormal platelet function (HP:0011869)1.75249136
174Bowel incontinence (HP:0002607)1.74775403
175Volvulus (HP:0002580)1.74397048
176Basal cell carcinoma (HP:0002671)1.74393463
177Metaphyseal cupping (HP:0003021)1.73988019
178Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71925116
179Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71925116
180Breech presentation (HP:0001623)1.71473465
181Hypercholesterolemia (HP:0003124)1.71288963
182Abnormal large intestine physiology (HP:0012700)1.70259951
183Multiple lipomas (HP:0001012)1.69027704
184Acanthocytosis (HP:0001927)1.68122684
185Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.67961426
186Abnormality of potassium homeostasis (HP:0011042)1.67379108
187Neoplasm of the colon (HP:0100273)1.66731969
188Seborrheic dermatitis (HP:0001051)1.66326924
189Uterine neoplasm (HP:0010784)1.66222862
190Ventricular fibrillation (HP:0001663)1.62810758
191Osteolytic defects of the hand bones (HP:0009699)1.62146359

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.72979565
2MAP4K14.55910116
3TTK3.91057399
4JAK32.52161069
5STK242.46981952
6EEF2K2.31360897
7FRK2.31171632
8TYK22.29635444
9LMTK22.27331509
10ZAP702.26380314
11MAP3K102.23606374
12MET2.21786768
13STK102.21295115
14TXK2.13128408
15MST42.12891676
16PKN22.08284958
17FLT32.02414756
18TAOK31.97475024
19TBK11.91780820
20MAP3K141.85935012
21CDK121.81257810
22ERN11.75272963
23GRK61.67281816
24BMX1.67120592
25FGFR41.65458711
26ITK1.65418619
27SMG11.62863188
28PBK1.60923680
29RPS6KA41.56063282
30MAPK151.56024176
31IKBKE1.55410648
32MST1R1.55204282
33TRIB31.53678308
34PTK61.50494403
35STK391.49627017
36TEC1.47406394
37PASK1.47320917
38BTK1.43871334
39BRSK21.41863903
40TNIK1.41017692
41STK31.40322444
42CSF1R1.39458586
43RPS6KB21.39291353
44JAK11.39274682
45FGFR31.38909156
46NEK21.37040744
47NEK11.34930091
48NME21.33382699
49KIT1.30348088
50SYK1.29754174
51IKBKB1.29228787
52LRRK21.28748417
53CSK1.27490094
54WNK41.27208258
55PDK21.23639049
56MAP2K21.23432994
57BLK1.21887964
58TESK21.21776899
59EIF2AK11.21143165
60LCK1.20576261
61CHUK1.19553506
62SCYL21.16348207
63NLK1.12900918
64PNCK1.11586955
65PIM11.11290501
66IRAK41.08681163
67ACVR1B1.08253125
68CDC71.07021442
69CAMK1G1.03553815
70MAP3K21.03062098
71TESK11.00549340
72MAP3K130.96538849
73HIPK20.96333948
74TGFBR20.94644740
75EPHB20.91029699
76CDK40.90522225
77HCK0.87896940
78LATS10.87464482
79MAP3K80.87364386
80PRKG20.87207109
81TGFBR10.85917308
82MKNK10.85891015
83STK40.85879929
84CDK90.83577530
85PLK40.82198173
86EPHB10.80632759
87KSR10.78990197
88LYN0.78236613
89CDK60.75280007
90JAK20.74283104
91STK160.73230198
92ZAK0.70495396
93CHEK20.67461826
94MELK0.66269732
95MARK30.64198078
96DYRK30.64146313
97MAP3K120.63168983
98PLK10.62791192
99PAK40.62692906
100FGFR10.62510152
101CLK10.61268317
102AURKB0.61051063
103FGFR20.60308040
104CAMK1D0.59389608
105ATR0.59318959
106RIPK10.59201366
107KSR20.58871796
108LATS20.57388673
109MAPK110.57166888
110NME10.56428535
111CDK190.55308621
112ERBB40.54121705
113WEE10.53815135
114OXSR10.53500003
115EPHA30.53478090
116NEK90.53145190
117BCR0.52699505
118MKNK20.51810022
119CHEK10.50832217
120ERBB20.50394114
121NEK60.50163216
122MATK0.49800925
123PRKD20.49765256
124MAPKAPK20.49127744
125IRAK30.48840476
126PIM20.48052741
127TRPM70.48015682
128MAP3K10.46447180
129KDR0.45428683
130WNK10.44350147
131MAP3K70.44003920
132DYRK1B0.43976649
133BRD40.43970260
134BRAF0.43451548
135PRKCQ0.43449839
136ICK0.42616045
137ALK0.41333511
138TSSK60.40368712
139PIK3CA0.38679550
140PDGFRB0.38044467
141PRKCI0.37644656
142YES10.37192001
143MAPKAPK30.36958073
144RET0.36838005
145MAPKAPK50.36363598
146RIPK40.35862057
147PDGFRA0.35627631
148NUAK10.35057891
149PRKCH0.34582170
150BUB10.33752316
151SRPK10.33592450
152PDPK10.30839541
153STK38L0.30223477
154CDC42BPA0.29870267
155PLK30.29738010
156MTOR0.29611255
157BMPR20.28390655
158PRPF4B0.27452447
159PTK20.25831075

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.86274655
2Cyanoamino acid metabolism_Homo sapiens_hsa004602.97597616
3Antigen processing and presentation_Homo sapiens_hsa046122.64190748
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.43234114
5B cell receptor signaling pathway_Homo sapiens_hsa046622.29009242
6Fructose and mannose metabolism_Homo sapiens_hsa000512.25239724
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.16059948
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08336408
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.06830706
10Renin-angiotensin system_Homo sapiens_hsa046142.05117164
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.05105885
12T cell receptor signaling pathway_Homo sapiens_hsa046602.04113526
13Non-homologous end-joining_Homo sapiens_hsa034502.00818947
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.97113483
15Galactose metabolism_Homo sapiens_hsa000521.94476904
16Glutathione metabolism_Homo sapiens_hsa004801.92821097
17Leishmaniasis_Homo sapiens_hsa051401.89776146
18DNA replication_Homo sapiens_hsa030301.87356351
19Osteoclast differentiation_Homo sapiens_hsa043801.86871179
20Measles_Homo sapiens_hsa051621.86027481
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.83656074
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.82813960
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78631643
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.77816329
25Histidine metabolism_Homo sapiens_hsa003401.76391288
26Vitamin digestion and absorption_Homo sapiens_hsa049771.75799586
27Starch and sucrose metabolism_Homo sapiens_hsa005001.70578098
28Retinol metabolism_Homo sapiens_hsa008301.65253009
29Arginine biosynthesis_Homo sapiens_hsa002201.64942754
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.59531033
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58478676
32Pentose phosphate pathway_Homo sapiens_hsa000301.56724877
33Mismatch repair_Homo sapiens_hsa034301.56610476
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56090805
35Chemical carcinogenesis_Homo sapiens_hsa052041.55867600
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54637790
37Herpes simplex infection_Homo sapiens_hsa051681.50656091
38Hematopoietic cell lineage_Homo sapiens_hsa046401.49727570
39Toxoplasmosis_Homo sapiens_hsa051451.49552352
40Base excision repair_Homo sapiens_hsa034101.44811052
41* Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43334921
42Acute myeloid leukemia_Homo sapiens_hsa052211.39199337
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37116289
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37060481
45Nitrogen metabolism_Homo sapiens_hsa009101.36900071
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.36765366
47Chronic myeloid leukemia_Homo sapiens_hsa052201.36392424
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36366472
49Fatty acid degradation_Homo sapiens_hsa000711.35780237
50Apoptosis_Homo sapiens_hsa042101.35468648
51Carbon metabolism_Homo sapiens_hsa012001.33237230
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31531570
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.29714787
54Protein digestion and absorption_Homo sapiens_hsa049741.29283170
55Pyruvate metabolism_Homo sapiens_hsa006201.28069635
56Thyroid cancer_Homo sapiens_hsa052161.27646599
57Other glycan degradation_Homo sapiens_hsa005111.27517803
58Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27247593
59Ribosome_Homo sapiens_hsa030101.26367412
60Shigellosis_Homo sapiens_hsa051311.25877510
61Legionellosis_Homo sapiens_hsa051341.24822129
62Influenza A_Homo sapiens_hsa051641.24635809
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23464733
64TNF signaling pathway_Homo sapiens_hsa046681.22276264
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22091564
66Tight junction_Homo sapiens_hsa045301.20588448
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20005193
68Hepatitis B_Homo sapiens_hsa051611.19911648
69Drug metabolism - other enzymes_Homo sapiens_hsa009831.18250479
70Tyrosine metabolism_Homo sapiens_hsa003501.17736302
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13302415
72Biosynthesis of amino acids_Homo sapiens_hsa012301.12353705
73Phenylalanine metabolism_Homo sapiens_hsa003601.11911084
74Caffeine metabolism_Homo sapiens_hsa002321.11361235
75Pancreatic cancer_Homo sapiens_hsa052121.11090117
76Chemokine signaling pathway_Homo sapiens_hsa040621.10176968
77Viral carcinogenesis_Homo sapiens_hsa052031.08074524
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03810958
79Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03663026
80Arginine and proline metabolism_Homo sapiens_hsa003301.03129891
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02787240
82Steroid biosynthesis_Homo sapiens_hsa001001.02396652
83Prolactin signaling pathway_Homo sapiens_hsa049171.00698669
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.99581739
85Small cell lung cancer_Homo sapiens_hsa052220.98871953
86Protein export_Homo sapiens_hsa030600.98681919
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98578315
88p53 signaling pathway_Homo sapiens_hsa041150.98159403
89Bile secretion_Homo sapiens_hsa049760.98040799
90Spliceosome_Homo sapiens_hsa030400.97673207
91Hepatitis C_Homo sapiens_hsa051600.97271303
92Allograft rejection_Homo sapiens_hsa053300.94980679
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.93625449
94Sphingolipid metabolism_Homo sapiens_hsa006000.92336306
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.92010254
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91366774
97HTLV-I infection_Homo sapiens_hsa051660.89530045
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87588210
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86469147
100Pertussis_Homo sapiens_hsa051330.85379374
101Epstein-Barr virus infection_Homo sapiens_hsa051690.85181689
102Cell cycle_Homo sapiens_hsa041100.84509566
103Platelet activation_Homo sapiens_hsa046110.83687118
104Viral myocarditis_Homo sapiens_hsa054160.83210618
105Linoleic acid metabolism_Homo sapiens_hsa005910.81814553
106Homologous recombination_Homo sapiens_hsa034400.81664239
107Mineral absorption_Homo sapiens_hsa049780.78117689
108Non-small cell lung cancer_Homo sapiens_hsa052230.76970734
109Fatty acid metabolism_Homo sapiens_hsa012120.76595942
110Colorectal cancer_Homo sapiens_hsa052100.75134817
111Tuberculosis_Homo sapiens_hsa051520.74989715
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74055232
113N-Glycan biosynthesis_Homo sapiens_hsa005100.72793337
114Salmonella infection_Homo sapiens_hsa051320.72723740
115Graft-versus-host disease_Homo sapiens_hsa053320.71576365
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71522173
117Arachidonic acid metabolism_Homo sapiens_hsa005900.70273566
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70267986
119PPAR signaling pathway_Homo sapiens_hsa033200.70145475
120Basal cell carcinoma_Homo sapiens_hsa052170.68667296
121VEGF signaling pathway_Homo sapiens_hsa043700.68605310
122Sulfur metabolism_Homo sapiens_hsa009200.68142258
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65989145
124Autoimmune thyroid disease_Homo sapiens_hsa053200.64974597
125Propanoate metabolism_Homo sapiens_hsa006400.64132078
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.62692489
127Thyroid hormone synthesis_Homo sapiens_hsa049180.61533736
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56319747
129One carbon pool by folate_Homo sapiens_hsa006700.54801634
130Type I diabetes mellitus_Homo sapiens_hsa049400.54498069
131Folate biosynthesis_Homo sapiens_hsa007900.53602323
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53555280
133Lysosome_Homo sapiens_hsa041420.53387406
134RNA transport_Homo sapiens_hsa030130.53235467
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.52857301
136MicroRNAs in cancer_Homo sapiens_hsa052060.52571147
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52076707
138Vibrio cholerae infection_Homo sapiens_hsa051100.51534285
139Nucleotide excision repair_Homo sapiens_hsa034200.48301324
140Hedgehog signaling pathway_Homo sapiens_hsa043400.48072922
141Bladder cancer_Homo sapiens_hsa052190.47664663
142* Metabolic pathways_Homo sapiens_hsa011000.47633105
143Fat digestion and absorption_Homo sapiens_hsa049750.45703537
144Prostate cancer_Homo sapiens_hsa052150.45605702
145Endometrial cancer_Homo sapiens_hsa052130.44950408
146Glycerolipid metabolism_Homo sapiens_hsa005610.44644325
147Asthma_Homo sapiens_hsa053100.44183045
148Fatty acid elongation_Homo sapiens_hsa000620.40924184
149Adherens junction_Homo sapiens_hsa045200.40673828
150RNA degradation_Homo sapiens_hsa030180.40661762
151Pancreatic secretion_Homo sapiens_hsa049720.40207144
152FoxO signaling pathway_Homo sapiens_hsa040680.39725833
153beta-Alanine metabolism_Homo sapiens_hsa004100.39170859
154Insulin resistance_Homo sapiens_hsa049310.38585633
155Sulfur relay system_Homo sapiens_hsa041220.37834814
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.36954373
157Selenocompound metabolism_Homo sapiens_hsa004500.34405645
158Type II diabetes mellitus_Homo sapiens_hsa049300.34362772
159Huntingtons disease_Homo sapiens_hsa050160.34209405
160Ether lipid metabolism_Homo sapiens_hsa005650.34168702
161mTOR signaling pathway_Homo sapiens_hsa041500.33432276
162Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32869231
163Pyrimidine metabolism_Homo sapiens_hsa002400.32649162
164Inositol phosphate metabolism_Homo sapiens_hsa005620.30834197
165Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28162275
166mRNA surveillance pathway_Homo sapiens_hsa030150.27338290
167Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26544875
168alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20084376
169Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19087142

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