ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	4.56662505
2	regulation of sequestering of triglyceride (GO:0010889)	4.52325084
3	retina vasculature morphogenesis in camera-type eye (GO:0061299)	4.34700615
4	vascular endothelial growth factor signaling pathway (GO:0038084)	4.34005073
5	ovulation from ovarian follicle (GO:0001542)	4.28696645
6	fatty acid transmembrane transport (GO:1902001)	4.26994113
7	central nervous system myelination (GO:0022010)	4.18404083
8	axon ensheathment in central nervous system (GO:0032291)	4.18404083
9	lymph vessel development (GO:0001945)	3.99001509
10	carnitine shuttle (GO:0006853)	3.93084891
11	low-density lipoprotein particle clearance (GO:0034383)	3.90514727
12	peripheral nervous system axon ensheathment (GO:0032292)	3.87472205
13	myelination in peripheral nervous system (GO:0022011)	3.87472205
14	neuronal ion channel clustering (GO:0045161)	3.86198588
15	glomerular filtration (GO:0003094)	3.85754602
16	positive regulation of respiratory burst (GO:0060267)	3.75830650
17	plasma membrane repair (GO:0001778)	3.75374713
18	extracellular matrix assembly (GO:0085029)	3.66618995
19	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.51096739
20	astrocyte differentiation (GO:0048708)	3.46526655
21	renal filtration (GO:0097205)	3.44445546
22	dermatan sulfate biosynthetic process (GO:0030208)	3.42365011
23	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.40355603
24	cardiac myofibril assembly (GO:0055003)	3.40012274
25	cellular response to vascular endothelial growth factor stimulus (GO:0035924)	3.38484467
26	transcytosis (GO:0045056)	3.32623776
27	brown fat cell differentiation (GO:0050873)	3.27588542
28	regulation of skeletal muscle contraction (GO:0014819)	3.24683285
29	myofibril assembly (GO:0030239)	3.22098969
30	sarcomere organization (GO:0045214)	3.21577180
31	cell migration involved in heart development (GO:0060973)	3.20692599
32	dermatan sulfate metabolic process (GO:0030205)	3.18853458
33	lymphangiogenesis (GO:0001946)	3.18429776
34	negative regulation of Rho protein signal transduction (GO:0035024)	3.18258193
35	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	3.17234512
36	muscle filament sliding (GO:0030049)	3.15591716
37	actin-myosin filament sliding (GO:0033275)	3.15591716
38	heart trabecula formation (GO:0060347)	3.13388126
39	regulation of p38MAPK cascade (GO:1900744)	3.12601925
40	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.11958767
41	positive regulation of macrophage cytokine production (GO:0060907)	3.10430813
42	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	3.09000143
43	keratan sulfate catabolic process (GO:0042340)	3.08347440
44	carnitine transmembrane transport (GO:1902603)	3.06624791
45	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	3.06612757
46	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	3.04835781
47	cellular potassium ion homeostasis (GO:0030007)	3.01489266
48	regulation of cholesterol storage (GO:0010885)	2.98760751
49	one-carbon compound transport (GO:0019755)	2.96253989
50	blood vessel maturation (GO:0001955)	2.90573926
51	surfactant homeostasis (GO:0043129)	2.89990131
52	basement membrane organization (GO:0071711)	2.89737155
53	cGMP biosynthetic process (GO:0006182)	2.88846651
54	regulation of actin filament-based movement (GO:1903115)	2.88739611
55	barbed-end actin filament capping (GO:0051016)	2.88662283
56	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.88235580
57	extracellular fibril organization (GO:0043206)	2.85601264
58	cGMP-mediated signaling (GO:0019934)	2.85140937
59	negative regulation of protein autophosphorylation (GO:0031953)	2.84225231
60	astrocyte development (GO:0014002)	2.82122899
61	detection of molecule of bacterial origin (GO:0032490)	2.81829368
62	regulation of cell communication by electrical coupling (GO:0010649)	2.80652128
63	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	2.79463509
64	cAMP biosynthetic process (GO:0006171)	2.78939605
65	biotin metabolic process (GO:0006768)	2.76674777
66	potassium ion import (GO:0010107)	2.76640634
67	actin-mediated cell contraction (GO:0070252)	2.76228865
68	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.76218878
69	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	2.76205329
70	amino-acid betaine transport (GO:0015838)	2.75883075
71	carnitine transport (GO:0015879)	2.75883075
72	axon ensheathment (GO:0008366)	2.75334652
73	ensheathment of neurons (GO:0007272)	2.75334652
74	regulation of relaxation of muscle (GO:1901077)	2.73528100
75	activation of protein kinase A activity (GO:0034199)	2.73003075
76	lipid particle organization (GO:0034389)	2.72551317
77	positive regulation of fatty acid oxidation (GO:0046321)	2.72480950
78	sarcoplasmic reticulum calcium ion transport (GO:0070296)	2.72260559
79	postsynaptic membrane organization (GO:0001941)	2.71260498
80	creatine metabolic process (GO:0006600)	2.70530333
81	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	2.70157557
82	ventricular cardiac muscle cell action potential (GO:0086005)	2.69221365
83	fibroblast migration (GO:0010761)	2.69097338
84	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.68721800
85	myelination (GO:0042552)	2.68334860
86	protein heterotrimerization (GO:0070208)	2.68249355
87	triglyceride catabolic process (GO:0019433)	2.67427835
88	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.66949959
89	cardiac muscle contraction (GO:0060048)	2.66485757
90	skeletal muscle adaptation (GO:0043501)	2.65027999
91	positive regulation of lipid storage (GO:0010884)	2.64556444
92	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.63513010
93	positive regulation of p38MAPK cascade (GO:1900745)	2.62351293
94	growth hormone receptor signaling pathway (GO:0060396)	2.61597705
95	regulation of fatty acid oxidation (GO:0046320)	2.61154799
96	white fat cell differentiation (GO:0050872)	2.60859766
97	negative regulation of complement activation (GO:0045916)	2.60382681
98	synaptic vesicle maturation (GO:0016188)	2.60345766
99	cellular response to epinephrine stimulus (GO:0071872)	2.59232285
100	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.58277705
101	venous blood vessel morphogenesis (GO:0048845)	2.56003361
102	vascular endothelial growth factor receptor signaling pathway (GO:0048010)	2.55152598
103	response to dietary excess (GO:0002021)	2.54480285
104	metanephric mesenchyme development (GO:0072075)	2.54428906
105	negative regulation of catenin import into nucleus (GO:0035414)	2.53839689
106	chemical homeostasis within a tissue (GO:0048875)	2.53684346
107	locomotory exploration behavior (GO:0035641)	2.53568135
108	metanephric nephron tubule development (GO:0072234)	2.53430132
109	metanephric tubule development (GO:0072170)	2.53430132
110	intracellular lipid transport (GO:0032365)	2.53030964
111	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.52872773
112	neuronal action potential propagation (GO:0019227)	2.52611583
113	gas transport (GO:0015669)	2.51622765
114	regulation of macrophage cytokine production (GO:0010935)	2.51272929
115	tricarboxylic acid cycle (GO:0006099)	2.50802588
116	fatty acid beta-oxidation (GO:0006635)	2.50703739
117	negative regulation of potassium ion transmembrane transport (GO:1901380)	2.50262932
118	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.50251223
119	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.49170047
120	L-amino acid import (GO:0043092)	2.48549715
121	behavioral response to pain (GO:0048266)	2.48175357
122	cardiac muscle cell proliferation (GO:0060038)	2.47377505
123	endothelium development (GO:0003158)	2.47039549
124	negative regulation of cardiac muscle tissue growth (GO:0055022)	2.46335080
125	negative regulation of heart growth (GO:0061117)	2.46335080
126	relaxation of cardiac muscle (GO:0055119)	2.44926977
127	metanephric nephron epithelium development (GO:0072243)	2.44395045
128	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.44146486
129	regulation of endothelial cell differentiation (GO:0045601)	2.42929687
130	phagocytosis, recognition (GO:0006910)	2.42762811
131	regulation of membrane repolarization (GO:0060306)	2.42359365
132	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	2.41589551
133	presynaptic membrane organization (GO:0097090)	2.41043416
134	sodium ion export (GO:0071436)	2.39284548
135	acylglycerol catabolic process (GO:0046464)	2.38886376
136	neutral lipid catabolic process (GO:0046461)	2.38886376
137	vocalization behavior (GO:0071625)	2.38208869
138	collagen fibril organization (GO:0030199)	2.38009195
139	cellular response to growth hormone stimulus (GO:0071378)	2.37337359
140	endothelial cell morphogenesis (GO:0001886)	2.37097009
141	leukocyte migration involved in inflammatory response (GO:0002523)	2.36113936
142	striated muscle hypertrophy (GO:0014897)	2.35227029
143	glutamate secretion (GO:0014047)	2.34860305
144	regulation of macrophage derived foam cell differentiation (GO:0010743)	2.34762723
145	glomerular basement membrane development (GO:0032836)	2.34715090
146	mesenchymal-epithelial cell signaling (GO:0060638)	2.33688672
147	chondroitin sulfate catabolic process (GO:0030207)	2.33640776
148	endocrine hormone secretion (GO:0060986)	2.33602675
149	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.33418719
150	protein localization to cell surface (GO:0034394)	2.31620396
151	fibril organization (GO:0097435)	2.28079367
152	negative regulation of leukocyte chemotaxis (GO:0002689)	2.27115214
153	metanephric epithelium development (GO:0072207)	2.27062175
154	muscle cell migration (GO:0014812)	2.26098958
155	sequestering of extracellular ligand from receptor (GO:0035581)	2.26076298
156	negative regulation of protein localization to cell surface (GO:2000009)	2.25477472
157	detection of calcium ion (GO:0005513)	2.24934258
158	kidney mesenchyme development (GO:0072074)	2.24445680
159	myoblast migration (GO:0051451)	2.23684994
160	positive regulation of fibroblast migration (GO:0010763)	2.21909868
161	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.20961469
162	potassium ion homeostasis (GO:0055075)	2.19776719
163	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.19590770
164	response to epinephrine (GO:0071871)	2.18331996
165	regulation of chemokine-mediated signaling pathway (GO:0070099)	2.18300362
166	cell communication by electrical coupling (GO:0010644)	2.16300027
167	regulation of female receptivity (GO:0045924)	2.15486894
168	virion attachment to host cell (GO:0019062)	2.15368788
169	adhesion of symbiont to host cell (GO:0044650)	2.15368788
170	neuron projection regeneration (GO:0031102)	2.15103270
171	cyclic purine nucleotide metabolic process (GO:0052652)	2.14474438
172	import into cell (GO:0098657)	2.14035761
173	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.14007251
174	presynaptic membrane assembly (GO:0097105)	2.13817178
175	amino acid import (GO:0043090)	2.13778377
176	negative regulation of smooth muscle cell migration (GO:0014912)	2.12033494
177	smooth muscle tissue development (GO:0048745)	2.10792679
178	cellular response to catecholamine stimulus (GO:0071870)	2.10422862
179	cellular response to monoamine stimulus (GO:0071868)	2.10422862
180	positive regulation of glucose import (GO:0046326)	2.08301622
181	regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)	2.07498082
182	membrane depolarization during action potential (GO:0086010)	2.06914598

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	5.01092209
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.54852882
3	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.36311999
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.34851444
5	EP300_21415370_ChIP-Seq_HL-1_Mouse	2.33601337
6	CLOCK_20551151_ChIP-Seq_293T_Human	2.24770622
7	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	2.24285598
8	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.12928261
9	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.02855929
10	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.97295991
11	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.94508324
12	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.91566728
13	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.91566728
14	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.90785918
15	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.87190140
16	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.85859881
17	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.81133411
18	DROSHA_22980978_ChIP-Seq_HELA_Human	1.80793674
19	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.77079152
20	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.77079152
21	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.66594316
22	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.65077596
23	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.62308781
24	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.61792848
25	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.61175783
26	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.59925003
27	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.59393895
28	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.59020079
29	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.58531415
30	GATA1_22025678_ChIP-Seq_K562_Human	1.53221023
31	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.52099078
32	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.50532510
33	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.49455479
34	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.47952839
35	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.45937836
36	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.44009410
37	GBX2_23144817_ChIP-Seq_PC3_Human	1.41238506
38	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.40783038
39	CJUN_26792858_Chip-Seq_BT549_Human	1.38935636
40	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.36761710
41	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.34752981
42	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.33242596
43	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.31005683
44	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.30314888
45	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.29910382
46	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.28066336
47	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.25513746
48	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	1.24796737
49	AHR_22903824_ChIP-Seq_MCF-7_Human	1.24293784
50	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.23659830
51	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.20862009
52	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.20088371
53	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.18472261
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.14879601
55	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.14247524
56	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.13987531
57	AR_21572438_ChIP-Seq_LNCaP_Human	1.13607400
58	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.12785911
59	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.12170127
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.11814064
61	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.10454464
62	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.08625753
63	BCAT_22108803_ChIP-Seq_LS180_Human	1.08032133
64	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.07893355
65	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.05338626
66	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.05338626
67	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04422343
68	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.03563349
69	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.03517918
70	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.99658335
71	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.98999282
72	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.98712575
73	STAT3_23295773_ChIP-Seq_U87_Human	0.98460164
74	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98160783
75	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.98062616
76	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.97985442
77	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.96931393
78	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.95852437
79	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.95781724
80	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.95472808
81	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.95157709
82	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.94658936
83	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.94544276
84	KDM2B_26808549_Chip-Seq_REH_Human	0.94166965
85	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.92229494
86	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.91832417
87	KDM2B_26808549_Chip-Seq_K562_Human	0.91553979
88	TCF4_23295773_ChIP-Seq_U87_Human	0.90761419
89	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.90021767
90	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.89797912
91	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.89482048
92	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.89287417
93	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89230513
94	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.88929806
95	AR_19668381_ChIP-Seq_PC3_Human	0.88917199
96	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.88697064
97	TP53_16413492_ChIP-PET_HCT116_Human	0.88502890
98	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.88495399
99	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.88396747
100	RARB_27405468_Chip-Seq_BRAIN_Mouse	0.88233284
101	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.87310835
102	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.87091810
103	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.86753671
104	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.86328310
105	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.86115767
106	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.85988671
107	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.85931799
108	TP53_18474530_ChIP-ChIP_U2OS_Human	0.85896153
109	P300_19829295_ChIP-Seq_ESCs_Human	0.85751626
110	SMAD4_21799915_ChIP-Seq_A2780_Human	0.83340127
111	ZNF263_19887448_ChIP-Seq_K562_Human	0.82326246
112	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.82284688
113	SOX2_20726797_ChIP-Seq_SW620_Human	0.81370944
114	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.81046818
115	RXR_22108803_ChIP-Seq_LS180_Human	0.80769925
116	VDR_24787735_ChIP-Seq_THP-1_Human	0.80738341
117	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.80585716
118	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.80563663
119	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.78538591
120	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.77869375
121	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.77578510
122	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.77566777
123	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.76565018
124	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.76163967
125	GATA1_19941826_ChIP-Seq_K562_Human	0.75346251
126	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.75145720
127	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.75046556
128	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.74316709
129	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.74117198
130	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.73965129

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005670_abnormal_white_adipose	4.20450674
2	MP0002837_dystrophic_cardiac_calcinosis	4.18381411
3	MP0008438_abnormal_cutaneous_collagen	4.06052478
4	MP0000751_myopathy	3.77770272
5	MP0004130_abnormal_muscle_cell	3.54419588
6	MP0004215_abnormal_myocardial_fiber	3.34788616
7	MP0010368_abnormal_lymphatic_system	3.21405657
8	MP0004084_abnormal_cardiac_muscle	3.16815276
9	MP0004036_abnormal_muscle_relaxation	2.88763069
10	MP0001879_abnormal_lymphatic_vessel	2.86014820
11	MP0000013_abnormal_adipose_tissue	2.73147282
12	MP0005275_abnormal_skin_tensile	2.72748637
13	MP0003646_muscle_fatigue	2.71997821
14	MP0005666_abnormal_adipose_tissue	2.63893638
15	MP0003724_increased_susceptibility_to	2.55621151
16	MP0004272_abnormal_basement_membrane	2.52928478
17	MP0000749_muscle_degeneration	2.29539620
18	MP0005330_cardiomyopathy	2.22027719
19	MP0003011_delayed_dark_adaptation	2.20934159
20	MP0004185_abnormal_adipocyte_glucose	2.18937482
21	MP0004145_abnormal_muscle_electrophysio	2.18834202
22	MP0005375_adipose_tissue_phenotype	2.17788730
23	MP0005423_abnormal_somatic_nervous	2.07154402
24	MP0003828_pulmonary_edema	2.06005271
25	MP0005167_abnormal_blood-brain_barrier	2.03099014
26	MP0005620_abnormal_muscle_contractility	2.02688617
27	MP0000750_abnormal_muscle_regeneration	2.01343843
28	MP0008775_abnormal_heart_ventricle	1.93197306
29	MP0004087_abnormal_muscle_fiber	1.93099740
30	MP0006138_congestive_heart_failure	1.91245596
31	MP0004859_abnormal_synaptic_plasticity	1.90057293
32	MP0004484_altered_response_of	1.86925450
33	MP0000003_abnormal_adipose_tissue	1.83447283
34	MP0002972_abnormal_cardiac_muscle	1.79483617
35	MP0000920_abnormal_myelination	1.77483725
36	MP0002254_reproductive_system_inflammat	1.77236262
37	MP0001958_emphysema	1.71907890
38	MP0001544_abnormal_cardiovascular_syste	1.71896291
39	MP0005385_cardiovascular_system_phenoty	1.71896291
40	MP0004885_abnormal_endolymph	1.67277922
41	MP0000343_altered_response_to	1.65663503
42	MP0002106_abnormal_muscle_physiology	1.63522193
43	MP0003279_aneurysm	1.61566339
44	MP0003045_fibrosis	1.52978990
45	MP0001486_abnormal_startle_reflex	1.50689840
46	MP0002272_abnormal_nervous_system	1.49434136
47	MP0003950_abnormal_plasma_membrane	1.48889040
48	MP0002971_abnormal_brown_adipose	1.46933832
49	MP0003635_abnormal_synaptic_transmissio	1.46266706
50	MP0005257_abnormal_intraocular_pressure	1.44982231
51	MP0005508_abnormal_skeleton_morphology	1.44750278
52	MP0000759_abnormal_skeletal_muscle	1.44258845
53	MP0004270_analgesia	1.43866889
54	MP0005369_muscle_phenotype	1.42693246
55	MP0003191_abnormal_cellular_cholesterol	1.40507603
56	MP0001502_abnormal_circadian_rhythm	1.40293173
57	MP0010630_abnormal_cardiac_muscle	1.39490576
58	MP0001299_abnormal_eye_distance/	1.37882600
59	MP0003633_abnormal_nervous_system	1.37283621
60	MP0002064_seizures	1.36817313
61	MP0005503_abnormal_tendon_morphology	1.34398985
62	MP0002332_abnormal_exercise_endurance	1.34332718
63	MP0006054_spinal_hemorrhage	1.31957150
64	MP0004085_abnormal_heartbeat	1.29812787
65	MP0003880_abnormal_central_pattern	1.29043590
66	MP0003329_amyloid_beta_deposits	1.27905378
67	MP0002108_abnormal_muscle_morphology	1.27743053
68	MP0002933_joint_inflammation	1.22702266
69	MP0004510_myositis	1.21483428
70	MP0001984_abnormal_olfaction	1.19477985
71	MP0009745_abnormal_behavioral_response	1.18892701
72	MP0003566_abnormal_cell_adhesion	1.18573544
73	MP0002063_abnormal_learning/memory/cond	1.18377573
74	MP0005165_increased_susceptibility_to	1.18137431
75	MP0003137_abnormal_impulse_conducting	1.17622879
76	MP0001986_abnormal_taste_sensitivity	1.17267744
77	MP0002638_abnormal_pupillary_reflex	1.16389627
78	MP0000747_muscle_weakness	1.15282949
79	MP0005551_abnormal_eye_electrophysiolog	1.14424757
80	MP0009046_muscle_twitch	1.14396041
81	MP0002269_muscular_atrophy	1.14188189
82	MP0003705_abnormal_hypodermis_morpholog	1.12171649
83	MP0003631_nervous_system_phenotype	1.09472153
84	MP0005595_abnormal_vascular_smooth	1.09166177
85	MP0003634_abnormal_glial_cell	1.08648481
86	MP0006276_abnormal_autonomic_nervous	1.07619027
87	MP0004147_increased_porphyrin_level	1.06514733
88	MP0000767_abnormal_smooth_muscle	1.06151244
89	MP0009115_abnormal_fat_cell	1.04679821
90	MP0008569_lethality_at_weaning	1.04432643
91	MP0008004_abnormal_stomach_pH	1.02745768
92	MP0002735_abnormal_chemical_nociception	1.00317110
93	MP0003879_abnormal_hair_cell	1.00158969
94	MP0000230_abnormal_systemic_arterial	1.00042896
95	MP0002295_abnormal_pulmonary_circulatio	0.98796808
96	MP0005646_abnormal_pituitary_gland	0.96631669
97	MP0010329_abnormal_lipoprotein_level	0.95739158
98	MP0003690_abnormal_glial_cell	0.94657473
99	MP0002734_abnormal_mechanical_nocicepti	0.94400969
100	MP0001970_abnormal_pain_threshold	0.92017419
101	MP0005334_abnormal_fat_pad	0.91567035
102	MP0000249_abnormal_blood_vessel	0.91066589
103	MP0005164_abnormal_response_to	0.90982647
104	MP0003632_abnormal_nervous_system	0.90814079
105	MP0005023_abnormal_wound_healing	0.89196641
106	MP0002572_abnormal_emotion/affect_behav	0.88872296
107	MP0005623_abnormal_meninges_morphology	0.88777168
108	MP0001661_extended_life_span	0.87435127
109	MP0001542_abnormal_bone_strength	0.87373821
110	MP0002896_abnormal_bone_mineralization	0.84371042
111	MP0000604_amyloidosis	0.82724019
112	MP0002127_abnormal_cardiovascular_syste	0.81319111
113	MP0002128_abnormal_blood_circulation	0.77879658
114	MP0003283_abnormal_digestive_organ	0.77436945
115	MP0001177_atelectasis	0.77312206
116	MP0005253_abnormal_eye_physiology	0.77119862
117	MP0001905_abnormal_dopamine_level	0.76658469
118	MP0000778_abnormal_nervous_system	0.76652542
119	MP0001851_eye_inflammation	0.76309719
120	MP0003959_abnormal_lean_body	0.73953393
121	MP0002133_abnormal_respiratory_system	0.73927773
122	MP0005388_respiratory_system_phenotype	0.73927773
123	MP0001440_abnormal_grooming_behavior	0.73228882
124	MP0005535_abnormal_body_temperature	0.73124777
125	MP0009384_cardiac_valve_regurgitation	0.72952647
126	MP0001968_abnormal_touch/_nociception	0.72847405
127	MP0000163_abnormal_cartilage_morphology	0.72227098
128	MP0002118_abnormal_lipid_homeostasis	0.72211521
129	MP0009780_abnormal_chondrocyte_physiolo	0.71978120
130	MP0002733_abnormal_thermal_nociception	0.71939858
131	MP0002060_abnormal_skin_morphology	0.70202092
132	MP0004883_abnormal_blood_vessel	0.70100008
133	MP0001501_abnormal_sleep_pattern	0.68109524
134	MP0000266_abnormal_heart_morphology	0.67873277
135	MP0002876_abnormal_thyroid_physiology	0.67654507
136	MP0002998_abnormal_bone_remodeling	0.65699317
137	MP0008961_abnormal_basal_metabolism	0.64217722
138	MP0002909_abnormal_adrenal_gland	0.63213941
139	MP0001614_abnormal_blood_vessel	0.62634608
140	MP0001727_abnormal_embryo_implantation	0.59641546
141	MP0000733_abnormal_muscle_development	0.59381810
142	MP0001881_abnormal_mammary_gland	0.58791344
143	MP0003300_gastrointestinal_ulcer	0.56851230
144	MP0002078_abnormal_glucose_homeostasis	0.55919830
145	MP0003948_abnormal_gas_homeostasis	0.55125132
146	MP0009764_decreased_sensitivity_to	0.54616521
147	MP0002970_abnormal_white_adipose	0.54600665
148	MP0002166_altered_tumor_susceptibility	0.51863735
149	MP0001533_abnormal_skeleton_physiology	0.51649754
150	MP0010386_abnormal_urinary_bladder	0.50533979
151	MP0005171_absent_coat_pigmentation	0.50079511

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Muscle fiber splitting (HP:0003555)	5.83070871
2	Protrusio acetabuli (HP:0003179)	5.35255640
3	Increased connective tissue (HP:0009025)	5.17251732
4	Hyporeflexia of lower limbs (HP:0002600)	4.86294613
5	Broad metatarsal (HP:0001783)	4.66105490
6	Ventricular tachycardia (HP:0004756)	4.57516405
7	Sudden death (HP:0001699)	4.52936158
8	Exercise-induced myalgia (HP:0003738)	4.45175708
9	Difficulty running (HP:0009046)	4.27659183
10	Calf muscle hypertrophy (HP:0008981)	4.26751312
11	Atrial fibrillation (HP:0005110)	4.20229026
12	Action tremor (HP:0002345)	4.18056664
13	Right ventricular cardiomyopathy (HP:0011663)	4.17302511
14	Muscle hypertrophy of the lower extremities (HP:0008968)	4.10508935
15	Type 1 muscle fiber predominance (HP:0003803)	3.98025344
16	Primary atrial arrhythmia (HP:0001692)	3.85980701
17	Lipoatrophy (HP:0100578)	3.74534538
18	Supraventricular arrhythmia (HP:0005115)	3.73146175
19	Increased variability in muscle fiber diameter (HP:0003557)	3.69040760
20	Cerebral aneurysm (HP:0004944)	3.62513969
21	Supraventricular tachycardia (HP:0004755)	3.62201071
22	Abnormality of the calf musculature (HP:0001430)	3.55488393
23	Myoglobinuria (HP:0002913)	3.51679190
24	Exercise-induced muscle cramps (HP:0003710)	3.48138993
25	Myotonia (HP:0002486)	3.45864302
26	Prolonged QT interval (HP:0001657)	3.40016894
27	Aortic dissection (HP:0002647)	3.39491501
28	Oligomenorrhea (HP:0000876)	3.34422850
29	Ulnar claw (HP:0001178)	3.30010652
30	Abnormality of skeletal muscle fiber size (HP:0012084)	3.29727656
31	Aortic aneurysm (HP:0004942)	3.12960522
32	Syncope (HP:0001279)	3.10815985
33	EMG: myopathic abnormalities (HP:0003458)	3.06602154
34	Facial diplegia (HP:0001349)	3.04971538
35	Shallow orbits (HP:0000586)	2.99117873
36	Asymmetric septal hypertrophy (HP:0001670)	2.89648166
37	Bundle branch block (HP:0011710)	2.88680873
38	Premature rupture of membranes (HP:0001788)	2.85573874
39	Pulmonary artery stenosis (HP:0004415)	2.82921447
40	Soft skin (HP:0000977)	2.80763925
41	Acanthosis nigricans (HP:0000956)	2.80241072
42	Abnormality of complement system (HP:0005339)	2.80166498
43	Palpitations (HP:0001962)	2.80022100
44	Overgrowth (HP:0001548)	2.78663390
45	Wormian bones (HP:0002645)	2.77949270
46	Spinal rigidity (HP:0003306)	2.77830703
47	Dilated cardiomyopathy (HP:0001644)	2.74814978
48	Muscle stiffness (HP:0003552)	2.72093611
49	Muscle fiber inclusion bodies (HP:0100299)	2.66696639
50	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.62865384
51	Polycythemia (HP:0001901)	2.61115330
52	Distal lower limb muscle weakness (HP:0009053)	2.59507390
53	Slender build (HP:0001533)	2.57567561
54	Hypoplasia of the iris (HP:0007676)	2.56514532
55	Bladder diverticulum (HP:0000015)	2.52476423
56	Striae distensae (HP:0001065)	2.50909764
57	Cervical subluxation (HP:0003308)	2.46735972
58	Heart block (HP:0012722)	2.46670008
59	Complement deficiency (HP:0004431)	2.44891752
60	Focal seizures (HP:0007359)	2.44712235
61	Focal motor seizures (HP:0011153)	2.42115644
62	Ankle contracture (HP:0006466)	2.42100201
63	Difficulty climbing stairs (HP:0003551)	2.41876145
64	Testicular atrophy (HP:0000029)	2.40130426
65	Rhabdomyolysis (HP:0003201)	2.39782441
66	Abnormal atrioventricular conduction (HP:0005150)	2.39162231
67	Insulin-resistant diabetes mellitus (HP:0000831)	2.37337310
68	Short hallux (HP:0010109)	2.36625006
69	Ventricular arrhythmia (HP:0004308)	2.35450795
70	Limited hip movement (HP:0008800)	2.35354283
71	Abnormal eating behavior (HP:0100738)	2.33507081
72	Aneurysm (HP:0002617)	2.33347914
73	Neck muscle weakness (HP:0000467)	2.32793605
74	Abnormal EKG (HP:0003115)	2.31217394
75	Wrist flexion contracture (HP:0001239)	2.29633687
76	Atrioventricular block (HP:0001678)	2.29245468
77	Neurofibrillary tangles (HP:0002185)	2.27030497
78	Mild short stature (HP:0003502)	2.26448344
79	Coronal craniosynostosis (HP:0004440)	2.24358125
80	Subaortic stenosis (HP:0001682)	2.24089988
81	Abnormality of the left ventricular outflow tract (HP:0011103)	2.24089988
82	Mildly elevated creatine phosphokinase (HP:0008180)	2.22652294
83	Dilatation of the ascending aorta (HP:0005111)	2.20808546
84	Obstructive sleep apnea (HP:0002870)	2.18652039
85	Vertebral compression fractures (HP:0002953)	2.18212643
86	Hypoplastic ischia (HP:0003175)	2.17856744
87	Nemaline bodies (HP:0003798)	2.17255527
88	Arterial tortuosity (HP:0005116)	2.17050357
89	Hypoalphalipoproteinemia (HP:0003233)	2.15261477
90	Hypertriglyceridemia (HP:0002155)	2.15016462
91	Ventricular fibrillation (HP:0001663)	2.12076692
92	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.11592884
93	Systemic lupus erythematosus (HP:0002725)	2.11375571
94	Increased corneal curvature (HP:0100692)	2.10608833
95	Keratoconus (HP:0000563)	2.10608833
96	Vascular tortuosity (HP:0004948)	2.10095801
97	Turricephaly (HP:0000262)	2.09964985
98	Foot dorsiflexor weakness (HP:0009027)	2.08955737
99	Rectal prolapse (HP:0002035)	2.08582918
100	Peripheral hypomyelination (HP:0007182)	2.07719153
101	Hyperextensible skin (HP:0000974)	2.07268413
102	Ketoacidosis (HP:0001993)	2.06744994
103	Round ear (HP:0100830)	2.05553865
104	Reduced subcutaneous adipose tissue (HP:0003758)	2.04842653
105	Follicular hyperkeratosis (HP:0007502)	2.04789142
106	Abnormality of binocular vision (HP:0011514)	2.04061410
107	Diplopia (HP:0000651)	2.04061410
108	Areflexia of lower limbs (HP:0002522)	2.02714005
109	Muscular dystrophy (HP:0003560)	2.00877699
110	Scapular winging (HP:0003691)	2.00060099
111	Hypoventilation (HP:0002791)	2.00046414
112	Proximal amyotrophy (HP:0007126)	1.99613778
113	Aplasia involving bones of the upper limbs (HP:0009823)	1.99320039
114	Aplasia of the phalanges of the hand (HP:0009802)	1.99320039
115	Aplasia involving bones of the extremities (HP:0009825)	1.99320039
116	Increased CSF protein (HP:0002922)	1.99210947
117	Neonatal short-limb short stature (HP:0008921)	1.99035278
118	Hemorrhage of the eye (HP:0011885)	1.98946977
119	Mitral regurgitation (HP:0001653)	1.98454006
120	Abnormality of the ischium (HP:0003174)	1.98370141
121	Venous abnormality (HP:0002624)	1.98345794
122	Hematochezia (HP:0002573)	1.97955592
123	Steppage gait (HP:0003376)	1.97000477
124	Torticollis (HP:0000473)	1.96427437
125	Genu recurvatum (HP:0002816)	1.96186328
126	Abnormality of the foot musculature (HP:0001436)	1.94059472
127	Wide anterior fontanel (HP:0000260)	1.93168178
128	Bradycardia (HP:0001662)	1.92346116
129	Segmental peripheral demyelination/remyelination (HP:0003481)	1.91796317
130	Hemiplegia (HP:0002301)	1.91519882
131	Infantile muscular hypotonia (HP:0008947)	1.90621035
132	Metaphyseal dysplasia (HP:0100255)	1.90401129
133	Spondylolisthesis (HP:0003302)	1.89453403
134	Hyperkalemia (HP:0002153)	1.87396559
135	Cerebral hemorrhage (HP:0001342)	1.86618092
136	Hypoglycemic coma (HP:0001325)	1.86064888
137	Joint laxity (HP:0001388)	1.85733134
138	Aortic valve stenosis (HP:0001650)	1.85229256
139	Persistence of primary teeth (HP:0006335)	1.85167680
140	Bone cyst (HP:0012062)	1.84588134
141	Spinal cord compression (HP:0002176)	1.84226864
142	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.83362939
143	Bowel diverticulosis (HP:0005222)	1.82876199
144	Atonic seizures (HP:0010819)	1.82585573
145	Termporal pattern (HP:0011008)	1.82320903
146	Insidious onset (HP:0003587)	1.82320903
147	Large for gestational age (HP:0001520)	1.82126299
148	Joint stiffness (HP:0001387)	1.81547052
149	Bulbar palsy (HP:0001283)	1.80280599
150	Distal lower limb amyotrophy (HP:0008944)	1.78677994
151	Hyperglycinuria (HP:0003108)	1.76616529
152	Glomerulonephritis (HP:0000099)	1.76546171
153	Ovoid vertebral bodies (HP:0003300)	1.75355445
154	Mitral valve prolapse (HP:0001634)	1.75348562
155	Ulnar deviation of the wrist (HP:0003049)	1.75168832
156	Atrophic scars (HP:0001075)	1.74866450
157	Venous insufficiency (HP:0005293)	1.74711719
158	Aortic regurgitation (HP:0001659)	1.74108097
159	Pigmentary retinal degeneration (HP:0001146)	1.73330138
160	Amyloidosis (HP:0011034)	1.72065027
161	Neoplasm of the heart (HP:0100544)	1.71520588
162	Ankle clonus (HP:0011448)	1.70887464
163	Palpebral edema (HP:0100540)	1.70757089
164	Bell-shaped thorax (HP:0001591)	1.70443523
165	Lymphangioma (HP:0100764)	1.70198643
166	Broad ribs (HP:0000885)	1.69977007

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	5.42242207
2	TTN	4.17292352
3	KDR	3.59809064
4	RIPK1	3.32547162
5	TGFBR2	3.30655322
6	MYLK	3.07100467
7	MARK1	2.99801639
8	NTRK3	2.79853645
9	PHKG1	2.78999822
10	PHKG2	2.78999822
11	DMPK	2.39922036
12	OBSCN	2.31672773
13	TRIB3	2.30688141
14	LMTK2	2.18325914
15	LATS2	1.97817388
16	CAMK1D	1.94524249
17	CAMK1G	1.76115598
18	INSRR	1.75387309
19	NTRK2	1.73780738
20	PAK6	1.69765830
21	PDK2	1.68348254
22	GRK5	1.65182822
23	SIK1	1.55404915
24	UHMK1	1.55189003
25	NTRK1	1.53750768
26	EPHB1	1.49407356
27	PIK3CA	1.45782905
28	CAMK2B	1.42027618
29	BCKDK	1.38612016
30	EPHB2	1.36670330
31	PDK4	1.35321627
32	PDK3	1.35321627
33	EPHA4	1.32347819
34	MAPK12	1.24391444
35	PDGFRA	1.24264312
36	PRKAA2	1.23030113
37	FER	1.18443139
38	PTK2B	1.13838522
39	ADRBK1	1.13300789
40	JAK1	1.11179654
41	KIT	1.08035373
42	CASK	1.07187321
43	TYRO3	1.05465913
44	FRK	1.04972858
45	MAPK13	1.04279900
46	PRKD1	1.03522219
47	MAP2K3	1.00917274
48	FGFR4	0.98708812
49	ERN1	0.97871943
50	PINK1	0.97582235
51	ADRBK2	0.95593642
52	FGFR3	0.94366780
53	ABL2	0.94299635
54	MAPKAPK3	0.93812510
55	PRKCH	0.92432423
56	MAPKAPK5	0.91135532
57	CDK5	0.90499266
58	MST1R	0.89640862
59	NLK	0.87606107
60	PIK3CG	0.86632521
61	MAPK4	0.83989174
62	LATS1	0.83446276
63	PTK6	0.80824405
64	WNK1	0.80602354
65	CAMK4	0.79014509
66	PRKAA1	0.78472067
67	MAP3K6	0.77955264
68	PTK2	0.75973171
69	MAP3K7	0.75815836
70	MUSK	0.72978760
71	EPHA3	0.71534848
72	TRPM7	0.70551666
73	STK38	0.70542839
74	FGFR2	0.67975096
75	MAP3K3	0.66259578
76	CAMKK1	0.66194968
77	MOS	0.65106182
78	GRK1	0.64167522
79	ROCK1	0.62984228
80	CSK	0.62962280
81	CAMK2D	0.62662620
82	STK38L	0.62246144
83	CDC42BPA	0.62199205
84	PKN1	0.61675219
85	IRAK1	0.61443167
86	DDR2	0.61043258
87	IRAK3	0.60512060
88	PRKCE	0.60138958
89	PDPK1	0.59944347
90	TGFBR1	0.58320778
91	DAPK3	0.58101020
92	CAMK1	0.57532521
93	PAK3	0.57354076
94	GRK7	0.57218459
95	JAK2	0.57166755
96	EEF2K	0.51835639
97	DYRK1A	0.51447963
98	NEK6	0.50803300
99	GSK3A	0.50536766
100	PDGFRB	0.50114051
101	MAPK10	0.49815898
102	PRKD2	0.49709217
103	JAK3	0.49220844
104	FES	0.48347841
105	PRKCG	0.47824183
106	MAP3K4	0.47504623
107	LIMK1	0.47471725
108	RPS6KA3	0.47387594
109	CAMKK2	0.47324225
110	KSR2	0.46184931
111	ILK	0.46123660
112	PAK2	0.45617887
113	AKT3	0.45617195
114	SGK3	0.44938107
115	MARK2	0.44288346
116	SGK494	0.41954234
117	SGK223	0.41954234
118	CAMK2G	0.40792450
119	NEK9	0.40405810
120	RET	0.39707277
121	ROCK2	0.39383015
122	MAPK7	0.39295925
123	PRKD3	0.39024035
124	PRKG1	0.38214983
125	PRKG2	0.38002530
126	PRKACG	0.37440137
127	DAPK2	0.37027998
128	MAP2K4	0.36766233
129	IRAK2	0.35645943
130	SRC	0.34200931
131	PRKACA	0.34038972
132	MAP2K1	0.33607261
133	CAMK2A	0.33371904
134	PDK1	0.33155611
135	SGK2	0.32676631
136	MET	0.31063249
137	SGK1	0.30744747
138	IGF1R	0.30330179

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.78666481
2	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	2.59926198
3	Propanoate metabolism_Homo sapiens_hsa00640	2.58672830
4	Dilated cardiomyopathy_Homo sapiens_hsa05414	2.52668156
5	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	2.37466808
6	PPAR signaling pathway_Homo sapiens_hsa03320	2.33913045
7	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.95233833
8	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.93685845
9	Fatty acid degradation_Homo sapiens_hsa00071	1.93468452
10	ECM-receptor interaction_Homo sapiens_hsa04512	1.93008424
11	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.88870572
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.88492176
13	Histidine metabolism_Homo sapiens_hsa00340	1.88107354
14	Fatty acid metabolism_Homo sapiens_hsa01212	1.87583893
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.60246905
16	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.55094162
17	Focal adhesion_Homo sapiens_hsa04510	1.45491416
18	Renin secretion_Homo sapiens_hsa04924	1.42660565
19	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.40206938
20	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.39112213
21	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.30895974
22	Malaria_Homo sapiens_hsa05144	1.28678715
23	Caffeine metabolism_Homo sapiens_hsa00232	1.28140328
24	Amphetamine addiction_Homo sapiens_hsa05031	1.27827854
25	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.25936198
26	Cocaine addiction_Homo sapiens_hsa05030	1.25912986
27	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.25622377
28	Long-term potentiation_Homo sapiens_hsa04720	1.25159797
29	Insulin resistance_Homo sapiens_hsa04931	1.24218908
30	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.22662487
31	Dopaminergic synapse_Homo sapiens_hsa04728	1.15405557
32	Phototransduction_Homo sapiens_hsa04744	1.14400060
33	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.14281377
34	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.09811843
35	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.09127842
36	Viral myocarditis_Homo sapiens_hsa05416	1.05120238
37	AMPK signaling pathway_Homo sapiens_hsa04152	1.02782922
38	Glycerolipid metabolism_Homo sapiens_hsa00561	1.01174401
39	Calcium signaling pathway_Homo sapiens_hsa04020	1.00416759
40	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.00227699
41	beta-Alanine metabolism_Homo sapiens_hsa00410	0.99240770
42	Amoebiasis_Homo sapiens_hsa05146	0.98067023
43	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.95201120
44	Pyruvate metabolism_Homo sapiens_hsa00620	0.92986496
45	cAMP signaling pathway_Homo sapiens_hsa04024	0.92875316
46	Arginine and proline metabolism_Homo sapiens_hsa00330	0.92575635
47	Type II diabetes mellitus_Homo sapiens_hsa04930	0.92172592
48	Insulin signaling pathway_Homo sapiens_hsa04910	0.91549045
49	Complement and coagulation cascades_Homo sapiens_hsa04610	0.90652288
50	Salivary secretion_Homo sapiens_hsa04970	0.89328438
51	Serotonergic synapse_Homo sapiens_hsa04726	0.87146259
52	Gastric acid secretion_Homo sapiens_hsa04971	0.86428523
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.85792708
54	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.84936362
55	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.84349476
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.83720645
57	ABC transporters_Homo sapiens_hsa02010	0.83178184
58	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.82860726
59	Protein digestion and absorption_Homo sapiens_hsa04974	0.81982173
60	Circadian entrainment_Homo sapiens_hsa04713	0.80663648
61	Prion diseases_Homo sapiens_hsa05020	0.80512807
62	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.79942975
63	Circadian rhythm_Homo sapiens_hsa04710	0.79403787
64	Taste transduction_Homo sapiens_hsa04742	0.78990279
65	Long-term depression_Homo sapiens_hsa04730	0.78405008
66	Carbon metabolism_Homo sapiens_hsa01200	0.78358123
67	Mineral absorption_Homo sapiens_hsa04978	0.78195378
68	Melanogenesis_Homo sapiens_hsa04916	0.77197659
69	Fatty acid elongation_Homo sapiens_hsa00062	0.76046054
70	Tyrosine metabolism_Homo sapiens_hsa00350	0.75749159
71	Glucagon signaling pathway_Homo sapiens_hsa04922	0.75526185
72	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.75118064
73	Morphine addiction_Homo sapiens_hsa05032	0.74178405
74	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.72898106
75	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.71883626
76	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.70398409
77	Olfactory transduction_Homo sapiens_hsa04740	0.69828345
78	Nitrogen metabolism_Homo sapiens_hsa00910	0.68656040
79	Melanoma_Homo sapiens_hsa05218	0.68474903
80	African trypanosomiasis_Homo sapiens_hsa05143	0.67454491
81	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.67380286
82	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.66680361
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.65646687
84	Adherens junction_Homo sapiens_hsa04520	0.65267066
85	Glioma_Homo sapiens_hsa05214	0.64040700
86	Proteoglycans in cancer_Homo sapiens_hsa05205	0.62381052
87	Bile secretion_Homo sapiens_hsa04976	0.62076846
88	Alzheimers disease_Homo sapiens_hsa05010	0.61688903
89	Platelet activation_Homo sapiens_hsa04611	0.61666461
90	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.61475420
91	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.60445659
92	Glutamatergic synapse_Homo sapiens_hsa04724	0.59130014
93	Toxoplasmosis_Homo sapiens_hsa05145	0.59050448
94	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.57329567
95	GABAergic synapse_Homo sapiens_hsa04727	0.56742069
96	Arginine biosynthesis_Homo sapiens_hsa00220	0.56372736
97	Lysine degradation_Homo sapiens_hsa00310	0.56370153
98	MAPK signaling pathway_Homo sapiens_hsa04010	0.56019320
99	Butanoate metabolism_Homo sapiens_hsa00650	0.55618823
100	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.54277317
101	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.53713354
102	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.53591687
103	Ras signaling pathway_Homo sapiens_hsa04014	0.53257088
104	Rap1 signaling pathway_Homo sapiens_hsa04015	0.52985680
105	Tryptophan metabolism_Homo sapiens_hsa00380	0.51974319
106	Tight junction_Homo sapiens_hsa04530	0.51648099
107	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.51460206
108	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.50258115
109	Choline metabolism in cancer_Homo sapiens_hsa05231	0.50090663
110	Osteoclast differentiation_Homo sapiens_hsa04380	0.49979603
111	Estrogen signaling pathway_Homo sapiens_hsa04915	0.49353587
112	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.48077601
113	Pancreatic secretion_Homo sapiens_hsa04972	0.47998341
114	Cholinergic synapse_Homo sapiens_hsa04725	0.46099075
115	GnRH signaling pathway_Homo sapiens_hsa04912	0.45689192
116	Insulin secretion_Homo sapiens_hsa04911	0.44169606
117	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.44129316
118	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.43264319
119	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.43070367
120	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.42048457
121	Axon guidance_Homo sapiens_hsa04360	0.41628601
122	Oxidative phosphorylation_Homo sapiens_hsa00190	0.41529942
123	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.41483769
124	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.40478060
125	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.40214023
126	Parkinsons disease_Homo sapiens_hsa05012	0.39827795
127	Small cell lung cancer_Homo sapiens_hsa05222	0.39093735
128	Phenylalanine metabolism_Homo sapiens_hsa00360	0.37943886
129	Peroxisome_Homo sapiens_hsa04146	0.36325734
130	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.36203214
131	Gap junction_Homo sapiens_hsa04540	0.35687970
132	Nicotine addiction_Homo sapiens_hsa05033	0.34358417

GALNT15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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