

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative regulation of fatty acid transport (GO:2000192) | 4.57731713 |
| 2 | COPI coating of Golgi vesicle (GO:0048205) | 4.34997642 |
| 3 | Golgi transport vesicle coating (GO:0048200) | 4.34997642 |
| 4 | cell adhesion mediated by integrin (GO:0033627) | 4.29507754 |
| 5 | protein heterotrimerization (GO:0070208) | 4.16019419 |
| 6 | apoptotic cell clearance (GO:0043277) | 4.12124795 |
| 7 | polarized epithelial cell differentiation (GO:0030859) | 4.12024424 |
| 8 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 4.07884852 |
| 9 | protein retention in ER lumen (GO:0006621) | 3.91467556 |
| 10 | endodermal cell differentiation (GO:0035987) | 3.81659339 |
| 11 | collagen fibril organization (GO:0030199) | 3.77404092 |
| 12 | skin morphogenesis (GO:0043589) | 3.77090484 |
| 13 | peptidyl-proline hydroxylation (GO:0019511) | 3.71616711 |
| 14 | regulation of fatty acid beta-oxidation (GO:0031998) | 3.63488814 |
| 15 | activation of signaling protein activity involved in unfolded protein response (GO:0006987) | 3.59352164 |
| 16 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 3.53735619 |
| 17 | positive regulation of fatty acid beta-oxidation (GO:0032000) | 3.47663979 |
| 18 | positive regulation of histone deacetylation (GO:0031065) | 3.46405703 |
| 19 | positive regulation of nuclease activity (GO:0032075) | 3.45945154 |
| 20 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 3.44904442 |
| 21 | basement membrane organization (GO:0071711) | 3.39476297 |
| 22 | protein hydroxylation (GO:0018126) | 3.32388225 |
| 23 | protein localization to endosome (GO:0036010) | 3.31009466 |
| 24 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 3.30521627 |
| 25 | barbed-end actin filament capping (GO:0051016) | 3.29088744 |
| 26 | stress fiber assembly (GO:0043149) | 3.22850002 |
| 27 | negative regulation of cell size (GO:0045792) | 3.22305389 |
| 28 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 3.21969631 |
| 29 | regulation of vascular endothelial growth factor signaling pathway (GO:1900746) | 3.20223188 |
| 30 | collagen metabolic process (GO:0032963) | 3.17668900 |
| 31 | regulation of early endosome to late endosome transport (GO:2000641) | 3.17339539 |
| 32 | endoplasmic reticulum unfolded protein response (GO:0030968) | 3.16097472 |
| 33 | establishment of apical/basal cell polarity (GO:0035089) | 3.15309875 |
| 34 | 4-hydroxyproline metabolic process (GO:0019471) | 3.14867569 |
| 35 | positive regulation of endothelial cell apoptotic process (GO:2000353) | 3.13673847 |
| 36 | epithelial cell-cell adhesion (GO:0090136) | 3.12803217 |
| 37 | low-density lipoprotein particle clearance (GO:0034383) | 3.12592467 |
| 38 | chondrocyte proliferation (GO:0035988) | 3.10643003 |
| 39 | regulation of hippo signaling (GO:0035330) | 3.10564844 |
| 40 | adherens junction assembly (GO:0034333) | 3.09339321 |
| 41 | cell-substrate junction assembly (GO:0007044) | 3.08967640 |
| 42 | regulation of nuclease activity (GO:0032069) | 3.08961680 |
| 43 | multicellular organismal macromolecule metabolic process (GO:0044259) | 3.06037964 |
| 44 | collagen catabolic process (GO:0030574) | 3.05607428 |
| 45 | maternal placenta development (GO:0001893) | 3.04586366 |
| 46 | cell migration involved in sprouting angiogenesis (GO:0002042) | 3.00655782 |
| 47 | cellular response to unfolded protein (GO:0034620) | 2.98149415 |
| 48 | response to laminar fluid shear stress (GO:0034616) | 2.97252300 |
| 49 | membrane protein ectodomain proteolysis (GO:0006509) | 2.96664408 |
| 50 | multicellular organismal metabolic process (GO:0044236) | 2.96193038 |
| 51 | multicellular organismal catabolic process (GO:0044243) | 2.95535879 |
| 52 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 2.92821126 |
| 53 | desmosome organization (GO:0002934) | 2.92007661 |
| 54 | ER-nucleus signaling pathway (GO:0006984) | 2.91878048 |
| 55 | extracellular matrix disassembly (GO:0022617) | 2.91366384 |
| 56 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 2.90482956 |
| 57 | axon extension involved in axon guidance (GO:0048846) | 2.90482956 |
| 58 | positive regulation of glycogen biosynthetic process (GO:0045725) | 2.89714617 |
| 59 | positive regulation of blood vessel endothelial cell migration (GO:0043536) | 2.87962620 |
| 60 | semaphorin-plexin signaling pathway (GO:0071526) | 2.85659309 |
| 61 | hippo signaling (GO:0035329) | 2.83000176 |
| 62 | cellular response to vitamin (GO:0071295) | 2.80535173 |
| 63 | germ cell migration (GO:0008354) | 2.80324209 |
| 64 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr | 2.79356610 |
| 65 | positive regulation of osteoblast proliferation (GO:0033690) | 2.79335792 |
| 66 | pinocytosis (GO:0006907) | 2.78066228 |
| 67 | blood vessel endothelial cell migration (GO:0043534) | 2.77939942 |
| 68 | negative regulation of chondrocyte differentiation (GO:0032331) | 2.77134976 |
| 69 | establishment or maintenance of monopolar cell polarity (GO:0061339) | 2.75498366 |
| 70 | establishment of monopolar cell polarity (GO:0061162) | 2.75498366 |
| 71 | positive regulation of p38MAPK cascade (GO:1900745) | 2.75447069 |
| 72 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 2.75050288 |
| 73 | protein localization to cell surface (GO:0034394) | 2.74935890 |
| 74 | retina vasculature morphogenesis in camera-type eye (GO:0061299) | 2.74873200 |
| 75 | plasma membrane repair (GO:0001778) | 2.73549563 |
| 76 | response to fluid shear stress (GO:0034405) | 2.72446662 |
| 77 | regulation of tight junction assembly (GO:2000810) | 2.71908721 |
| 78 | hyaluronan catabolic process (GO:0030214) | 2.71764510 |
| 79 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition | 2.71641019 |
| 80 | cellular response to topologically incorrect protein (GO:0035967) | 2.71171569 |
| 81 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 2.70707021 |
| 82 | vascular endothelial growth factor receptor signaling pathway (GO:0048010) | 2.70491044 |
| 83 | substrate-dependent cell migration (GO:0006929) | 2.69623705 |
| 84 | vascular endothelial growth factor signaling pathway (GO:0038084) | 2.69288112 |
| 85 | midgut development (GO:0007494) | 2.68173271 |
| 86 | proline biosynthetic process (GO:0006561) | 2.67911631 |
| 87 | bone trabecula formation (GO:0060346) | 2.67815439 |
| 88 | heparan sulfate proteoglycan biosynthetic process (GO:0015012) | 2.67389503 |
| 89 | focal adhesion assembly (GO:0048041) | 2.67072229 |
| 90 | cell-substrate adherens junction assembly (GO:0007045) | 2.67072229 |
| 91 | paraxial mesoderm development (GO:0048339) | 2.65208646 |
| 92 | positive regulation of fatty acid oxidation (GO:0046321) | 2.64531996 |
| 93 | cortical actin cytoskeleton organization (GO:0030866) | 2.62893902 |
| 94 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 2.62492940 |
| 95 | apoptotic process involved in morphogenesis (GO:0060561) | 2.61044374 |
| 96 | substrate adhesion-dependent cell spreading (GO:0034446) | 2.59505088 |
| 97 | regulation of integrin activation (GO:0033623) | 2.59123178 |
| 98 | nuclear pore complex assembly (GO:0051292) | 2.58008205 |
| 99 | regulation of cholesterol homeostasis (GO:2000188) | 2.57917389 |
| 100 | regulation of cholesterol storage (GO:0010885) | 2.57517409 |
| 101 | response to endoplasmic reticulum stress (GO:0034976) | 2.56319543 |
| 102 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 2.56196289 |
| 103 | regulation of establishment of planar polarity (GO:0090175) | 2.55492461 |
| 104 | mitotic chromosome condensation (GO:0007076) | 2.55176973 |
| 105 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241) | 2.54447199 |
| 106 | regulation of SMAD protein import into nucleus (GO:0060390) | 2.54304096 |
| 107 | activation of Rac GTPase activity (GO:0032863) | 2.53578498 |
| 108 | atrioventricular valve morphogenesis (GO:0003181) | 2.52898559 |
| 109 | adhesion of symbiont to host (GO:0044406) | 2.51870731 |
| 110 | vesicle coating (GO:0006901) | 2.51820757 |
| 111 | cellular response to nutrient (GO:0031670) | 2.51421241 |
| 112 | protein maturation by protein folding (GO:0022417) | 2.51101670 |
| 113 | negative regulation of lipid transport (GO:0032369) | 2.50470114 |
| 114 | endocardial cushion development (GO:0003197) | 2.50344085 |
| 115 | mannose metabolic process (GO:0006013) | 2.49192613 |
| 116 | wound healing, spreading of epidermal cells (GO:0035313) | 2.48640608 |
| 117 | endothelial cell morphogenesis (GO:0001886) | 2.48579476 |
| 118 | hemidesmosome assembly (GO:0031581) | 2.47793319 |
| 119 | negative regulation of smooth muscle cell migration (GO:0014912) | 2.47646914 |
| 120 | pentose-phosphate shunt (GO:0006098) | 2.46609827 |
| 121 | embryo implantation (GO:0007566) | 2.46327802 |
| 122 | cellular response to vitamin D (GO:0071305) | 2.45419335 |
| 123 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 2.45285435 |
| 124 | venous blood vessel morphogenesis (GO:0048845) | 2.45170906 |
| 125 | regulation of translational fidelity (GO:0006450) | 2.44393384 |
| 126 | COPII vesicle coating (GO:0048208) | 2.43551991 |
| 127 | growth hormone receptor signaling pathway (GO:0060396) | 2.43475937 |
| 128 | mesodermal cell differentiation (GO:0048333) | 2.43042983 |
| 129 | regulation of extracellular matrix disassembly (GO:0010715) | 2.43015628 |
| 130 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 2.42474575 |
| 131 | glucose catabolic process (GO:0006007) | 2.42460651 |
| 132 | chondroitin sulfate biosynthetic process (GO:0030206) | 2.42295129 |
| 133 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 2.41496948 |
| 134 | wound healing, spreading of cells (GO:0044319) | 2.41431545 |
| 135 | negative regulation of catenin import into nucleus (GO:0035414) | 2.39971419 |
| 136 | positive regulation of astrocyte differentiation (GO:0048711) | 2.39590897 |
| 137 | hypotonic response (GO:0006971) | 2.38620239 |
| 138 | convergent extension (GO:0060026) | 2.38610869 |
| 139 | regulation of plasminogen activation (GO:0010755) | 2.38525401 |
| 140 | protein targeting to plasma membrane (GO:0072661) | 2.38261878 |
| 141 | regulation of glucose import in response to insulin stimulus (GO:2001273) | 2.38010590 |
| 142 | cochlea morphogenesis (GO:0090103) | 2.37961490 |
| 143 | positive regulation of protein deacetylation (GO:0090312) | 2.37063907 |
| 144 | NADPH regeneration (GO:0006740) | 2.34474387 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 4.42475338 |
| 2 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 4.01783198 |
| 3 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 3.95307336 |
| 4 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 3.31438455 |
| 5 | CLOCK_20551151_ChIP-Seq_293T_Human | 3.13154286 |
| 6 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.81542389 |
| 7 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.73682914 |
| 8 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.44501393 |
| 9 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.40463152 |
| 10 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.33910157 |
| 11 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 2.31105364 |
| 12 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.30950546 |
| 13 | MYC_22102868_ChIP-Seq_BL_Human | 2.28240459 |
| 14 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 2.27782934 |
| 15 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 2.27553632 |
| 16 | * KDM2B_26808549_Chip-Seq_DND41_Human | 2.12241572 |
| 17 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 2.04366354 |
| 18 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.97620972 |
| 19 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.96056751 |
| 20 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.95682963 |
| 21 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.91729415 |
| 22 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.89440308 |
| 23 | * P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.88403599 |
| 24 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.87276609 |
| 25 | * WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.87048407 |
| 26 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.85650759 |
| 27 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.84718591 |
| 28 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.84355876 |
| 29 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.84089260 |
| 30 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.81438046 |
| 31 | * RACK7_27058665_Chip-Seq_MCF-7_Human | 1.81407698 |
| 32 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.80761879 |
| 33 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.79249815 |
| 34 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.79013715 |
| 35 | ATF3_27146783_Chip-Seq_COLON_Human | 1.76161951 |
| 36 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.68673118 |
| 37 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.66634143 |
| 38 | KDM2B_26808549_Chip-Seq_K562_Human | 1.61281501 |
| 39 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.60931468 |
| 40 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.57737185 |
| 41 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.56932471 |
| 42 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.55704069 |
| 43 | * KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.55166916 |
| 44 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.54124016 |
| 45 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.53968850 |
| 46 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.50522408 |
| 47 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.50420115 |
| 48 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.50382025 |
| 49 | * KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.49633502 |
| 50 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.48820676 |
| 51 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.48104989 |
| 52 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.45794386 |
| 53 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.43682292 |
| 54 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.41863997 |
| 55 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.40505360 |
| 56 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.37278513 |
| 57 | * ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.36232329 |
| 58 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 1.35985335 |
| 59 | * PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.35656222 |
| 60 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.34315304 |
| 61 | * LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.33469168 |
| 62 | * UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.32116214 |
| 63 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.32092499 |
| 64 | * DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.31959190 |
| 65 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.30330407 |
| 66 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.27766511 |
| 67 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.27641487 |
| 68 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.27575063 |
| 69 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.26285113 |
| 70 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.25521143 |
| 71 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.25351360 |
| 72 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.25252915 |
| 73 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.25135164 |
| 74 | * UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.25069142 |
| 75 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.23000083 |
| 76 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.22537965 |
| 77 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.21925824 |
| 78 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.21184039 |
| 79 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.21070265 |
| 80 | * BRD4_25478319_ChIP-Seq_HGPS_Human | 1.17320087 |
| 81 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.16983404 |
| 82 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.16983404 |
| 83 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.16946969 |
| 84 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.14893064 |
| 85 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.14811031 |
| 86 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.14483352 |
| 87 | UTX_26944678_Chip-Seq_JUKART_Human | 1.14463345 |
| 88 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.14425017 |
| 89 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.14195830 |
| 90 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.14106932 |
| 91 | MAF_26560356_Chip-Seq_TH1_Human | 1.12887805 |
| 92 | * TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.11893238 |
| 93 | * TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.11893238 |
| 94 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.10933966 |
| 95 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 1.10460556 |
| 96 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.10378369 |
| 97 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.09376476 |
| 98 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.08929147 |
| 99 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.08826451 |
| 100 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.08345708 |
| 101 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.08219775 |
| 102 | * CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.07969852 |
| 103 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.07873143 |
| 104 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.07403764 |
| 105 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.06490623 |
| 106 | * SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.06173773 |
| 107 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.05651016 |
| 108 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.04356849 |
| 109 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.03426632 |
| 110 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.03041197 |
| 111 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.02764939 |
| 112 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.00826786 |
| 113 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.00650727 |
| 114 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.00153821 |
| 115 | * NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 0.99762194 |
| 116 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.99590336 |
| 117 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.99499636 |
| 118 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.98394544 |
| 119 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.98148170 |
| 120 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.96083348 |
| 121 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.95116521 |
| 122 | * CHD1_26751641_Chip-Seq_LNCaP_Human | 0.94640266 |
| 123 | * CJUN_26792858_Chip-Seq_BT549_Human | 0.94619139 |
| 124 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.94008966 |
| 125 | * ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.93784778 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008438_abnormal_cutaneous_collagen | 5.95792028 |
| 2 | MP0003705_abnormal_hypodermis_morpholog | 4.93338982 |
| 3 | MP0005275_abnormal_skin_tensile | 3.38451239 |
| 4 | MP0010352_gastrointestinal_tract_polyps | 2.81064084 |
| 5 | MP0005623_abnormal_meninges_morphology | 2.76123122 |
| 6 | MP0003566_abnormal_cell_adhesion | 2.64526172 |
| 7 | MP0005076_abnormal_cell_differentiation | 2.54931144 |
| 8 | MP0004272_abnormal_basement_membrane | 2.42492434 |
| 9 | MP0003279_aneurysm | 2.42369482 |
| 10 | MP0003300_gastrointestinal_ulcer | 2.30211772 |
| 11 | MP0006054_spinal_hemorrhage | 2.24474845 |
| 12 | MP0002877_abnormal_melanocyte_morpholog | 2.22826134 |
| 13 | MP0010234_abnormal_vibrissa_follicle | 2.20338341 |
| 14 | MP0005451_abnormal_body_composition | 2.05917773 |
| 15 | MP0001958_emphysema | 2.05245289 |
| 16 | MP0005503_abnormal_tendon_morphology | 1.97780341 |
| 17 | MP0005023_abnormal_wound_healing | 1.97691374 |
| 18 | MP0003091_abnormal_cell_migration | 1.91214551 |
| 19 | MP0003283_abnormal_digestive_organ | 1.81905952 |
| 20 | MP0009384_cardiac_valve_regurgitation | 1.79916876 |
| 21 | MP0004185_abnormal_adipocyte_glucose | 1.76044832 |
| 22 | MP0000733_abnormal_muscle_development | 1.71967307 |
| 23 | MP0005409_darkened_coat_color | 1.68657430 |
| 24 | MP0002060_abnormal_skin_morphology | 1.61347514 |
| 25 | MP0004858_abnormal_nervous_system | 1.59225387 |
| 26 | MP0000751_myopathy | 1.57169645 |
| 27 | MP0001348_abnormal_lacrimal_gland | 1.56969505 |
| 28 | MP0000013_abnormal_adipose_tissue | 1.52037466 |
| 29 | MP0003303_peritoneal_inflammation | 1.51240832 |
| 30 | MP0000537_abnormal_urethra_morphology | 1.47281553 |
| 31 | MP0002896_abnormal_bone_mineralization | 1.46637304 |
| 32 | MP0004130_abnormal_muscle_cell | 1.44413863 |
| 33 | MP0001849_ear_inflammation | 1.39580132 |
| 34 | MP0000579_abnormal_nail_morphology | 1.39464381 |
| 35 | MP0009053_abnormal_anal_canal | 1.38996751 |
| 36 | MP0005257_abnormal_intraocular_pressure | 1.38963441 |
| 37 | MP0003941_abnormal_skin_development | 1.37646546 |
| 38 | MP0000003_abnormal_adipose_tissue | 1.36649806 |
| 39 | MP0003045_fibrosis | 1.35327951 |
| 40 | MP0005375_adipose_tissue_phenotype | 1.34108207 |
| 41 | MP0009278_abnormal_bone_marrow | 1.33779000 |
| 42 | MP0000762_abnormal_tongue_morphology | 1.33184501 |
| 43 | MP0009780_abnormal_chondrocyte_physiolo | 1.28979932 |
| 44 | MP0005058_abnormal_lysosome_morphology | 1.24101156 |
| 45 | MP0005666_abnormal_adipose_tissue | 1.23484040 |
| 46 | MP0005508_abnormal_skeleton_morphology | 1.22184905 |
| 47 | MP0002295_abnormal_pulmonary_circulatio | 1.20199342 |
| 48 | MP0001661_extended_life_span | 1.17962908 |
| 49 | MP0003950_abnormal_plasma_membrane | 1.14968119 |
| 50 | MP0008260_abnormal_autophagy | 1.12874530 |
| 51 | MP0008961_abnormal_basal_metabolism | 1.10296838 |
| 52 | MP0005220_abnormal_exocrine_pancreas | 1.09051903 |
| 53 | MP0002089_abnormal_postnatal_growth/wei | 1.07955541 |
| 54 | MP0000534_abnormal_ureter_morphology | 1.06826472 |
| 55 | MP0001299_abnormal_eye_distance/ | 1.05738329 |
| 56 | MP0003115_abnormal_respiratory_system | 1.05274270 |
| 57 | MP0003329_amyloid_beta_deposits | 1.03637337 |
| 58 | MP0001243_abnormal_dermal_layer | 1.02193646 |
| 59 | MP0004233_abnormal_muscle_weight | 1.02021080 |
| 60 | MP0003453_abnormal_keratinocyte_physiol | 0.99605877 |
| 61 | MP0000428_abnormal_craniofacial_morphol | 0.99469965 |
| 62 | MP0010368_abnormal_lymphatic_system | 0.99205191 |
| 63 | MP0005197_abnormal_uvea_morphology | 0.98485209 |
| 64 | MP0001915_intracranial_hemorrhage | 0.96720549 |
| 65 | MP0002168_other_aberrant_phenotype | 0.96716596 |
| 66 | MP0010030_abnormal_orbit_morphology | 0.95906568 |
| 67 | MP0005621_abnormal_cell_physiology | 0.95316888 |
| 68 | MP0000678_abnormal_parathyroid_gland | 0.93140257 |
| 69 | MP0000767_abnormal_smooth_muscle | 0.92238353 |
| 70 | MP0010307_abnormal_tumor_latency | 0.90142890 |
| 71 | MP0004808_abnormal_hematopoietic_stem | 0.89817585 |
| 72 | MP0005367_renal/urinary_system_phenotyp | 0.89669979 |
| 73 | MP0000516_abnormal_urinary_system | 0.89669979 |
| 74 | MP0000747_muscle_weakness | 0.89439710 |
| 75 | MP0003942_abnormal_urinary_system | 0.89363482 |
| 76 | MP0003385_abnormal_body_wall | 0.88880390 |
| 77 | MP0002998_abnormal_bone_remodeling | 0.88839801 |
| 78 | MP0004197_abnormal_fetal_growth/weight/ | 0.88817725 |
| 79 | MP0003172_abnormal_lysosome_physiology | 0.88521819 |
| 80 | MP0006138_congestive_heart_failure | 0.88422446 |
| 81 | MP0000858_altered_metastatic_potential | 0.87823750 |
| 82 | MP0002697_abnormal_eye_size | 0.87049782 |
| 83 | MP0001730_embryonic_growth_arrest | 0.84983269 |
| 84 | MP0001542_abnormal_bone_strength | 0.84372387 |
| 85 | MP0001533_abnormal_skeleton_physiology | 0.83534452 |
| 86 | MP0001216_abnormal_epidermal_layer | 0.83247706 |
| 87 | MP0004087_abnormal_muscle_fiber | 0.83172886 |
| 88 | MP0000750_abnormal_muscle_regeneration | 0.82353219 |
| 89 | MP0005390_skeleton_phenotype | 0.82333566 |
| 90 | MP0002269_muscular_atrophy | 0.81880461 |
| 91 | MP0009840_abnormal_foam_cell | 0.80356839 |
| 92 | MP0003448_altered_tumor_morphology | 0.79958052 |
| 93 | MP0000462_abnormal_digestive_system | 0.78397491 |
| 94 | MP0002282_abnormal_trachea_morphology | 0.78218192 |
| 95 | MP0002128_abnormal_blood_circulation | 0.77250986 |
| 96 | MP0009250_abnormal_appendicular_skeleto | 0.76736056 |
| 97 | MP0000163_abnormal_cartilage_morphology | 0.75575150 |
| 98 | MP0002115_abnormal_skeleton_extremities | 0.75551357 |
| 99 | MP0004947_skin_inflammation | 0.74556904 |
| 100 | MP0002925_abnormal_cardiovascular_devel | 0.74357596 |
| 101 | MP0002796_impaired_skin_barrier | 0.74296322 |
| 102 | MP0001614_abnormal_blood_vessel | 0.73956595 |
| 103 | MP0010630_abnormal_cardiac_muscle | 0.72543290 |
| 104 | MP0002166_altered_tumor_susceptibility | 0.71292194 |
| 105 | MP0002108_abnormal_muscle_morphology | 0.71135331 |
| 106 | MP0003252_abnormal_bile_duct | 0.69854504 |
| 107 | MP0005330_cardiomyopathy | 0.69516103 |
| 108 | MP0002113_abnormal_skeleton_development | 0.69241668 |
| 109 | MP0005193_abnormal_anterior_eye | 0.69216120 |
| 110 | MP0003795_abnormal_bone_structure | 0.68598593 |
| 111 | MP0002092_abnormal_eye_morphology | 0.68568281 |
| 112 | MP0005083_abnormal_biliary_tract | 0.68163317 |
| 113 | MP0002933_joint_inflammation | 0.67728507 |
| 114 | MP0008932_abnormal_embryonic_tissue | 0.67638471 |
| 115 | MP0003191_abnormal_cellular_cholesterol | 0.67479573 |
| 116 | MP0005595_abnormal_vascular_smooth | 0.67419600 |
| 117 | MP0000749_muscle_degeneration | 0.67205357 |
| 118 | MP0002080_prenatal_lethality | 0.67076875 |
| 119 | MP0000759_abnormal_skeletal_muscle | 0.66952141 |
| 120 | MP0000350_abnormal_cell_proliferation | 0.66581602 |
| 121 | MP0000467_abnormal_esophagus_morphology | 0.66020796 |
| 122 | MP0010771_integument_phenotype | 0.65509866 |
| 123 | MP0004782_abnormal_surfactant_physiolog | 0.65318784 |
| 124 | MP0002086_abnormal_extraembryonic_tissu | 0.65269516 |
| 125 | MP0000432_abnormal_head_morphology | 0.65221776 |
| 126 | MP0003959_abnormal_lean_body | 0.65081517 |
| 127 | MP0003984_embryonic_growth_retardation | 0.64542755 |
| 128 | MP0002932_abnormal_joint_morphology | 0.64059718 |
| 129 | MP0005670_abnormal_white_adipose | 0.62676558 |
| 130 | MP0003567_abnormal_fetal_cardiomyocyte | 0.62448821 |
| 131 | MP0000604_amyloidosis | 0.60180582 |
| 132 | MP0005501_abnormal_skin_physiology | 0.59881287 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Protrusio acetabuli (HP:0003179) | 5.83095087 |
| 2 | Premature rupture of membranes (HP:0001788) | 5.65375732 |
| 3 | Shallow orbits (HP:0000586) | 4.63627427 |
| 4 | Cerebral aneurysm (HP:0004944) | 4.63170214 |
| 5 | Ankle contracture (HP:0006466) | 3.78782801 |
| 6 | Peritonitis (HP:0002586) | 3.77545704 |
| 7 | Aortic dissection (HP:0002647) | 3.71644666 |
| 8 | Cervical subluxation (HP:0003308) | 3.52512664 |
| 9 | Atrophic scars (HP:0001075) | 3.45725056 |
| 10 | Aortic aneurysm (HP:0004942) | 3.22541457 |
| 11 | Dilatation of the ascending aorta (HP:0005111) | 3.18706414 |
| 12 | Mitral valve prolapse (HP:0001634) | 3.10978311 |
| 13 | Bladder diverticulum (HP:0000015) | 3.10828600 |
| 14 | Fragile skin (HP:0001030) | 2.99780609 |
| 15 | Genu recurvatum (HP:0002816) | 2.89689872 |
| 16 | Broad metatarsal (HP:0001783) | 2.84278455 |
| 17 | Aneurysm (HP:0002617) | 2.77515482 |
| 18 | Blue sclerae (HP:0000592) | 2.72921057 |
| 19 | Ulnar bowing (HP:0003031) | 2.66744399 |
| 20 | Soft skin (HP:0000977) | 2.66275850 |
| 21 | Distal lower limb amyotrophy (HP:0008944) | 2.64875804 |
| 22 | Increased connective tissue (HP:0009025) | 2.63719586 |
| 23 | Broad face (HP:0000283) | 2.59546818 |
| 24 | Distal upper limb amyotrophy (HP:0007149) | 2.56441962 |
| 25 | Upper limb amyotrophy (HP:0009129) | 2.56441962 |
| 26 | Increased density of long bones (HP:0006392) | 2.52921534 |
| 27 | Bowel diverticulosis (HP:0005222) | 2.50683996 |
| 28 | Type 1 muscle fiber predominance (HP:0003803) | 2.46715107 |
| 29 | Turricephaly (HP:0000262) | 2.46614120 |
| 30 | Wormian bones (HP:0002645) | 2.41195240 |
| 31 | Abnormality of dentin (HP:0010299) | 2.41031928 |
| 32 | Hand muscle atrophy (HP:0009130) | 2.39993889 |
| 33 | Subacute progressive viral hepatitis (HP:0006572) | 2.38587213 |
| 34 | Enlarged penis (HP:0000040) | 2.33966806 |
| 35 | Achilles tendon contracture (HP:0001771) | 2.32643853 |
| 36 | Natal tooth (HP:0000695) | 2.31378491 |
| 37 | Deviation of the hallux (HP:0010051) | 2.31349766 |
| 38 | Hallux valgus (HP:0001822) | 2.25632637 |
| 39 | Spinal rigidity (HP:0003306) | 2.22841306 |
| 40 | Buphthalmos (HP:0000557) | 2.22050294 |
| 41 | Hyperextensible skin (HP:0000974) | 2.21248420 |
| 42 | Wrist flexion contracture (HP:0001239) | 2.18492278 |
| 43 | Abnormality of the Achilles tendon (HP:0005109) | 2.16894389 |
| 44 | Flat acetabular roof (HP:0003180) | 2.16675146 |
| 45 | Vertebral compression fractures (HP:0002953) | 2.16611089 |
| 46 | Lymphangioma (HP:0100764) | 2.16436001 |
| 47 | Bowed forearm bones (HP:0003956) | 2.16220883 |
| 48 | Bowing of the arm (HP:0006488) | 2.16220883 |
| 49 | Thin bony cortex (HP:0002753) | 2.13481512 |
| 50 | Ankyloglossia (HP:0010296) | 2.12383638 |
| 51 | Hyperacusis (HP:0010780) | 2.10868088 |
| 52 | Abnormal delivery (HP:0001787) | 2.09832034 |
| 53 | Mitral stenosis (HP:0001718) | 2.09459616 |
| 54 | Elbow flexion contracture (HP:0002987) | 2.09128214 |
| 55 | Renal duplication (HP:0000075) | 2.08937882 |
| 56 | Vascular tortuosity (HP:0004948) | 2.08851249 |
| 57 | Radial bowing (HP:0002986) | 2.08743369 |
| 58 | Ectopia lentis (HP:0001083) | 2.08635901 |
| 59 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.07770044 |
| 60 | Long toe (HP:0010511) | 2.05578840 |
| 61 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.04030790 |
| 62 | Insomnia (HP:0100785) | 2.02755261 |
| 63 | Difficulty climbing stairs (HP:0003551) | 1.99848985 |
| 64 | Trismus (HP:0000211) | 1.98959579 |
| 65 | Scapular winging (HP:0003691) | 1.97503560 |
| 66 | Asymmetry of the thorax (HP:0001555) | 1.96833881 |
| 67 | Distal lower limb muscle weakness (HP:0009053) | 1.96386174 |
| 68 | Congenital glaucoma (HP:0001087) | 1.96245113 |
| 69 | Increased variability in muscle fiber diameter (HP:0003557) | 1.95504070 |
| 70 | Abnormality of the peritoneum (HP:0002585) | 1.95455483 |
| 71 | Striae distensae (HP:0001065) | 1.95027958 |
| 72 | Arterial tortuosity (HP:0005116) | 1.93720261 |
| 73 | Abnormality of the distal phalanges of the toes (HP:0010182) | 1.92297794 |
| 74 | Long palpebral fissure (HP:0000637) | 1.92170183 |
| 75 | Lower limb amyotrophy (HP:0007210) | 1.91321526 |
| 76 | Camptodactyly of toe (HP:0001836) | 1.91122069 |
| 77 | Breech presentation (HP:0001623) | 1.90960814 |
| 78 | Myocardial infarction (HP:0001658) | 1.88672283 |
| 79 | Abnormality of the calcaneus (HP:0008364) | 1.87635699 |
| 80 | Neonatal short-limb short stature (HP:0008921) | 1.86015551 |
| 81 | Abnormality of the acetabulum (HP:0003170) | 1.85800119 |
| 82 | Selective tooth agenesis (HP:0001592) | 1.85765952 |
| 83 | Osteolytic defects of the hand bones (HP:0009699) | 1.85019413 |
| 84 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.85019413 |
| 85 | Increased mean platelet volume (HP:0011877) | 1.84185306 |
| 86 | Advanced eruption of teeth (HP:0006288) | 1.83537051 |
| 87 | Abnormal ossification of hand bones (HP:0005921) | 1.83347978 |
| 88 | Aortic regurgitation (HP:0001659) | 1.83262802 |
| 89 | Slender build (HP:0001533) | 1.83119182 |
| 90 | Mucopolysacchariduria (HP:0008155) | 1.82711132 |
| 91 | Urinary glycosaminoglycan excretion (HP:0003541) | 1.82711132 |
| 92 | Back pain (HP:0003418) | 1.82101977 |
| 93 | Exostoses (HP:0100777) | 1.81524982 |
| 94 | Overgrowth (HP:0001548) | 1.81209498 |
| 95 | Biconcave vertebral bodies (HP:0004586) | 1.81002509 |
| 96 | Hypercortisolism (HP:0001578) | 1.80083494 |
| 97 | Dysostosis multiplex (HP:0000943) | 1.79972771 |
| 98 | Tibial bowing (HP:0002982) | 1.78256946 |
| 99 | Macroorchidism (HP:0000053) | 1.77327164 |
| 100 | Disproportionate tall stature (HP:0001519) | 1.77114859 |
| 101 | Deep venous thrombosis (HP:0002625) | 1.77040810 |
| 102 | Abnormality of oral frenula (HP:0000190) | 1.76113050 |
| 103 | Joint laxity (HP:0001388) | 1.75658598 |
| 104 | Coxa vara (HP:0002812) | 1.75462665 |
| 105 | Abnormality of carpal bone ossification (HP:0006257) | 1.75385726 |
| 106 | Milia (HP:0001056) | 1.75004251 |
| 107 | Spondylolisthesis (HP:0003302) | 1.73883353 |
| 108 | Abnormality of skeletal muscle fiber size (HP:0012084) | 1.73167230 |
| 109 | Persistence of primary teeth (HP:0006335) | 1.72642206 |
| 110 | Follicular hyperkeratosis (HP:0007502) | 1.71929215 |
| 111 | Short nail (HP:0001799) | 1.71694372 |
| 112 | Platyspondyly (HP:0000926) | 1.71629104 |
| 113 | Polygenic inheritance (HP:0010982) | 1.70746002 |
| 114 | Nonimmune hydrops fetalis (HP:0001790) | 1.70372350 |
| 115 | Spinal cord lesions (HP:0100561) | 1.70147822 |
| 116 | Syringomyelia (HP:0003396) | 1.70147822 |
| 117 | Broad ribs (HP:0000885) | 1.69768957 |
| 118 | Pterygium (HP:0001059) | 1.68632202 |
| 119 | Coronal craniosynostosis (HP:0004440) | 1.68387969 |
| 120 | Vertebral hypoplasia (HP:0008417) | 1.68193013 |
| 121 | Aplasia/Hypoplasia of the vertebrae (HP:0008515) | 1.68193013 |
| 122 | Mitral regurgitation (HP:0001653) | 1.66535360 |
| 123 | Osteopenia (HP:0000938) | 1.65286616 |
| 124 | Joint stiffness (HP:0001387) | 1.64747465 |
| 125 | Wide anterior fontanel (HP:0000260) | 1.63869343 |
| 126 | Osteoarthritis (HP:0002758) | 1.63726426 |
| 127 | Vertebral arch anomaly (HP:0008438) | 1.63565732 |
| 128 | Cerebral inclusion bodies (HP:0100314) | 1.62333588 |
| 129 | Infantile muscular hypotonia (HP:0008947) | 1.62327047 |
| 130 | Flat cornea (HP:0007720) | 1.62057203 |
| 131 | Abnormal platelet volume (HP:0011876) | 1.62039286 |
| 132 | Venous abnormality (HP:0002624) | 1.61817253 |
| 133 | Round ear (HP:0100830) | 1.60733977 |
| 134 | Generalized amyotrophy (HP:0003700) | 1.59969058 |
| 135 | Cupped ribs (HP:0000887) | 1.59280534 |
| 136 | Delayed cranial suture closure (HP:0000270) | 1.57757387 |
| 137 | Inguinal hernia (HP:0000023) | 1.56697050 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIB3 | 5.41480228 |
| 2 | PKN2 | 4.48392161 |
| 3 | EEF2K | 3.45592301 |
| 4 | DDR2 | 3.34677530 |
| 5 | ERN1 | 2.93654581 |
| 6 | TTN | 2.69747156 |
| 7 | PDGFRA | 2.68787703 |
| 8 | MAP3K10 | 2.67561720 |
| 9 | SMG1 | 2.53116993 |
| 10 | IRAK3 | 2.37059683 |
| 11 | PRPF4B | 2.28743867 |
| 12 | RIPK1 | 2.27216983 |
| 13 | SIK1 | 2.26697391 |
| 14 | PTK6 | 2.08223304 |
| 15 | SCYL2 | 1.95701096 |
| 16 | BMX | 1.77274302 |
| 17 | LATS2 | 1.73524221 |
| 18 | LRRK2 | 1.72018462 |
| 19 | LATS1 | 1.57329963 |
| 20 | ARAF | 1.56534269 |
| 21 | PAK2 | 1.56471767 |
| 22 | FLT3 | 1.48986879 |
| 23 | PTK2 | 1.43239482 |
| 24 | EPHA2 | 1.36041675 |
| 25 | PAK4 | 1.28838214 |
| 26 | FGFR4 | 1.27862871 |
| 27 | EPHB1 | 1.21645825 |
| 28 | TAOK2 | 1.20929796 |
| 29 | EPHB2 | 1.17763835 |
| 30 | ICK | 1.14697501 |
| 31 | MTOR | 1.13263034 |
| 32 | DYRK1B | 1.11911831 |
| 33 | PDGFRB | 1.08848735 |
| 34 | TRPM7 | 1.08568574 |
| 35 | TYRO3 | 1.05923682 |
| 36 | RET | 1.03464602 |
| 37 | PAK3 | 1.00625426 |
| 38 | EPHA3 | 0.98864472 |
| 39 | ILK | 0.96138432 |
| 40 | CDK6 | 0.95342370 |
| 41 | FER | 0.94815773 |
| 42 | MAP3K13 | 0.93560687 |
| 43 | NTRK1 | 0.93455928 |
| 44 | STK10 | 0.92276872 |
| 45 | ALK | 0.91325725 |
| 46 | CDC42BPA | 0.89986441 |
| 47 | TGFBR2 | 0.87411926 |
| 48 | ERBB4 | 0.87320066 |
| 49 | CLK1 | 0.85459790 |
| 50 | FRK | 0.85368915 |
| 51 | LIMK1 | 0.84129636 |
| 52 | FGFR1 | 0.83249891 |
| 53 | MYLK | 0.81614523 |
| 54 | CAMK1D | 0.79162603 |
| 55 | CDK12 | 0.79032223 |
| 56 | MAP3K9 | 0.78121073 |
| 57 | KSR2 | 0.78111378 |
| 58 | PRKCH | 0.77692683 |
| 59 | RPS6KB2 | 0.76936316 |
| 60 | MOS | 0.72485112 |
| 61 | CSK | 0.70877704 |
| 62 | CAMKK1 | 0.70561275 |
| 63 | PAK6 | 0.70229314 |
| 64 | CDK7 | 0.69831927 |
| 65 | MET | 0.69818705 |
| 66 | BRAF | 0.69530018 |
| 67 | DMPK | 0.68941072 |
| 68 | MAPK11 | 0.68436311 |
| 69 | MST1R | 0.67367461 |
| 70 | TESK2 | 0.67290340 |
| 71 | MAPKAPK3 | 0.67033843 |
| 72 | FGFR3 | 0.66943782 |
| 73 | PIK3CG | 0.66355022 |
| 74 | MAP2K1 | 0.63461528 |
| 75 | CDK8 | 0.63457265 |
| 76 | JAK1 | 0.62797176 |
| 77 | STK3 | 0.62251894 |
| 78 | MAP3K1 | 0.60555259 |
| 79 | MAP3K6 | 0.60469609 |
| 80 | MAP3K8 | 0.60112560 |
| 81 | STK38 | 0.59834426 |
| 82 | TESK1 | 0.59258942 |
| 83 | CAMK1G | 0.58815728 |
| 84 | PDPK1 | 0.55290882 |
| 85 | MAP3K2 | 0.54480896 |
| 86 | CDK9 | 0.53042414 |
| 87 | RAF1 | 0.51611927 |
| 88 | GSK3A | 0.51417217 |
| 89 | PRKD2 | 0.51382498 |
| 90 | INSR | 0.51295460 |
| 91 | ROCK2 | 0.50186020 |
| 92 | SIK2 | 0.48386651 |
| 93 | HIPK2 | 0.47496458 |
| 94 | RPS6KA4 | 0.47152119 |
| 95 | PIM2 | 0.46757071 |
| 96 | RPS6KA2 | 0.46101737 |
| 97 | AKT2 | 0.46046961 |
| 98 | MAP3K7 | 0.45665100 |
| 99 | PRKG2 | 0.45366647 |
| 100 | MAP3K3 | 0.45055019 |
| 101 | TAOK1 | 0.44908416 |
| 102 | PRKD3 | 0.44894843 |
| 103 | CDK4 | 0.44494421 |
| 104 | PRKD1 | 0.44315722 |
| 105 | GRK6 | 0.43207297 |
| 106 | PDK2 | 0.43126904 |
| 107 | MARK2 | 0.43047867 |
| 108 | DAPK3 | 0.43025485 |
| 109 | CSF1R | 0.41752114 |
| 110 | CDK11A | 0.40996464 |
| 111 | CDK15 | 0.40369844 |
| 112 | ABL2 | 0.40271056 |
| 113 | HCK | 0.39265730 |
| 114 | EGFR | 0.38240436 |
| 115 | MAP2K3 | 0.38056426 |
| 116 | LMTK2 | 0.38052433 |
| 117 | TBK1 | 0.37970764 |
| 118 | PAK1 | 0.37911837 |
| 119 | CDK14 | 0.37242989 |
| 120 | FGFR2 | 0.37040691 |
| 121 | JAK3 | 0.36904704 |
| 122 | MAP3K14 | 0.36621764 |
| 123 | RPS6KL1 | 0.36296794 |
| 124 | RPS6KC1 | 0.36296794 |
| 125 | JAK2 | 0.35936498 |
| 126 | NEK2 | 0.35911203 |
| 127 | NEK9 | 0.35691385 |
| 128 | ROCK1 | 0.34763195 |
| 129 | CDK18 | 0.34646812 |
| 130 | ZAP70 | 0.34541166 |
| 131 | RPS6KA1 | 0.34531233 |
| 132 | NEK1 | 0.33749278 |
| 133 | KSR1 | 0.33681116 |
| 134 | BRD4 | 0.33365689 |
| 135 | MATK | 0.33349405 |
| 136 | MELK | 0.32982116 |
| 137 | NME2 | 0.32754724 |
| 138 | MAP2K2 | 0.31322579 |
| 139 | AURKA | 0.29739221 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ECM-receptor interaction_Homo sapiens_hsa04512 | 2.65732295 |
| 2 | Focal adhesion_Homo sapiens_hsa04510 | 2.33623645 |
| 3 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.06280638 |
| 4 | Bladder cancer_Homo sapiens_hsa05219 | 2.00107205 |
| 5 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.96224670 |
| 6 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.94481385 |
| 7 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.88687252 |
| 8 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.86780421 |
| 9 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.82127740 |
| 10 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.81352033 |
| 11 | Amoebiasis_Homo sapiens_hsa05146 | 1.76720997 |
| 12 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.76698477 |
| 13 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.67968949 |
| 14 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.65491893 |
| 15 | Adherens junction_Homo sapiens_hsa04520 | 1.62124664 |
| 16 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.56795480 |
| 17 | Galactose metabolism_Homo sapiens_hsa00052 | 1.54145421 |
| 18 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.48613291 |
| 19 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.44945472 |
| 20 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.33676137 |
| 21 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.30722956 |
| 22 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.29775963 |
| 23 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.29144029 |
| 24 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.29048228 |
| 25 | Glioma_Homo sapiens_hsa05214 | 1.25970488 |
| 26 | Endometrial cancer_Homo sapiens_hsa05213 | 1.24841766 |
| 27 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.22499959 |
| 28 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.19557528 |
| 29 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.19448763 |
| 30 | Insulin resistance_Homo sapiens_hsa04931 | 1.15163479 |
| 31 | Viral myocarditis_Homo sapiens_hsa05416 | 1.13016434 |
| 32 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.12397265 |
| 33 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.11545067 |
| 34 | Lysosome_Homo sapiens_hsa04142 | 1.08895090 |
| 35 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.07894060 |
| 36 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.07591748 |
| 37 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 1.06870399 |
| 38 | AMPK signaling pathway_Homo sapiens_hsa04152 | 1.05756015 |
| 39 | Colorectal cancer_Homo sapiens_hsa05210 | 1.05736197 |
| 40 | Platelet activation_Homo sapiens_hsa04611 | 1.04063859 |
| 41 | Carbon metabolism_Homo sapiens_hsa01200 | 1.03122047 |
| 42 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.99954436 |
| 43 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.99765746 |
| 44 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.98953397 |
| 45 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.98367272 |
| 46 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.97196821 |
| 47 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.96617264 |
| 48 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.96595148 |
| 49 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.96550793 |
| 50 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.93866766 |
| 51 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.93754104 |
| 52 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.93082417 |
| 53 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.91537259 |
| 54 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.91001784 |
| 55 | Lysine degradation_Homo sapiens_hsa00310 | 0.89920992 |
| 56 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.89776201 |
| 57 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.89573908 |
| 58 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.88324290 |
| 59 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.87837903 |
| 60 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.87584018 |
| 61 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.87337516 |
| 62 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.84005191 |
| 63 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.83157359 |
| 64 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.82672053 |
| 65 | Tight junction_Homo sapiens_hsa04530 | 0.82590940 |
| 66 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.82248286 |
| 67 | Melanoma_Homo sapiens_hsa05218 | 0.81955672 |
| 68 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.81750965 |
| 69 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.81164900 |
| 70 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.80454337 |
| 71 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.79341996 |
| 72 | Prion diseases_Homo sapiens_hsa05020 | 0.77164358 |
| 73 | Prostate cancer_Homo sapiens_hsa05215 | 0.76824010 |
| 74 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.76795689 |
| 75 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.76193367 |
| 76 | Apoptosis_Homo sapiens_hsa04210 | 0.75358901 |
| 77 | Thyroid cancer_Homo sapiens_hsa05216 | 0.75066688 |
| 78 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.74744613 |
| 79 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.74124551 |
| 80 | Shigellosis_Homo sapiens_hsa05131 | 0.73507327 |
| 81 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.72942088 |
| 82 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.72889808 |
| 83 | Pathways in cancer_Homo sapiens_hsa05200 | 0.72107674 |
| 84 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.72000908 |
| 85 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.71520377 |
| 86 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.70249325 |
| 87 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.68833374 |
| 88 | Malaria_Homo sapiens_hsa05144 | 0.68290883 |
| 89 | Endocytosis_Homo sapiens_hsa04144 | 0.67846936 |
| 90 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.67117523 |
| 91 | Salmonella infection_Homo sapiens_hsa05132 | 0.66289210 |
| 92 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.66194545 |
| 93 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.66125846 |
| 94 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.66069564 |
| 95 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.66013465 |
| 96 | HTLV-I infection_Homo sapiens_hsa05166 | 0.65176643 |
| 97 | Axon guidance_Homo sapiens_hsa04360 | 0.64581900 |
| 98 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.64504840 |
| 99 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.62470626 |
| 100 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.62407384 |
| 101 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.61752370 |
| 102 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.61334518 |
| 103 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.59235785 |
| 104 | Other glycan degradation_Homo sapiens_hsa00511 | 0.57976863 |
| 105 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.57970952 |
| 106 | Hepatitis B_Homo sapiens_hsa05161 | 0.57970385 |
| 107 | Gap junction_Homo sapiens_hsa04540 | 0.57859316 |
| 108 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.57638516 |
| 109 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.56875670 |
| 110 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.56200410 |
| 111 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.55433960 |
| 112 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.55292104 |
| 113 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.54548800 |
| 114 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.54317029 |
| 115 | Cell cycle_Homo sapiens_hsa04110 | 0.53764310 |
| 116 | Bile secretion_Homo sapiens_hsa04976 | 0.52842882 |
| 117 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.52726196 |
| 118 | Melanogenesis_Homo sapiens_hsa04916 | 0.52632798 |
| 119 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.51976634 |
| 120 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.51902675 |
| 121 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.51703768 |
| 122 | Hepatitis C_Homo sapiens_hsa05160 | 0.48684130 |
| 123 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.47591362 |

