GALNT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members, however the enzymes have different substrate specificities. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.86340510
2cell wall macromolecule catabolic process (GO:0016998)8.88609363
3cell wall macromolecule metabolic process (GO:0044036)8.88609363
4multicellular organism reproduction (GO:0032504)8.44592703
5acrosome assembly (GO:0001675)8.43338676
6sperm motility (GO:0030317)8.36309725
7sperm-egg recognition (GO:0035036)8.18082452
8plasma membrane fusion (GO:0045026)7.97899444
9binding of sperm to zona pellucida (GO:0007339)7.50553548
10cell-cell recognition (GO:0009988)7.41737904
11axonemal dynein complex assembly (GO:0070286)7.24155559
12reproduction (GO:0000003)7.20319063
13epithelial cilium movement (GO:0003351)6.79798601
14acrosome reaction (GO:0007340)6.62317091
15spermatid development (GO:0007286)6.51205575
16piRNA metabolic process (GO:0034587)6.42910995
17motile cilium assembly (GO:0044458)6.33931769
18interferon-gamma secretion (GO:0072643)6.11610247
19cilium movement (GO:0003341)5.99395401
20male meiosis (GO:0007140)5.86865215
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.60818792
22synaptonemal complex organization (GO:0070193)5.52534717
23synaptonemal complex assembly (GO:0007130)5.46662242
24single fertilization (GO:0007338)5.41439980
25organic cation transport (GO:0015695)5.29524448
26sperm capacitation (GO:0048240)5.15849588
27hemidesmosome assembly (GO:0031581)5.13417103
28fertilization (GO:0009566)4.62721246
29negative regulation of keratinocyte proliferation (GO:0010839)4.56445820
30establishment of skin barrier (GO:0061436)4.56227509
31diterpenoid biosynthetic process (GO:0016102)4.49821769
32regulation of cilium movement (GO:0003352)4.48710838
33multicellular organismal water homeostasis (GO:0050891)4.43106033
34keratinocyte proliferation (GO:0043616)4.37044096
35regulation of podosome assembly (GO:0071801)4.12293326
36spermatogenesis (GO:0007283)4.04459645
37male gamete generation (GO:0048232)4.02635533
38cellular process involved in reproduction in multicellular organism (GO:0022412)3.85924996
39hypotonic response (GO:0006971)3.83451073
40water homeostasis (GO:0030104)3.81079549
41regulation of keratinocyte proliferation (GO:0010837)3.79956139
42DNA methylation involved in gamete generation (GO:0043046)3.75695342
43surfactant homeostasis (GO:0043129)3.74850710
44seminiferous tubule development (GO:0072520)3.73525298
45germ cell development (GO:0007281)3.71559787
46gamete generation (GO:0007276)3.70508957
47positive regulation of epidermal cell differentiation (GO:0045606)3.66782634
48negative regulation of inclusion body assembly (GO:0090084)3.63390160
49positive regulation of Cdc42 GTPase activity (GO:0043089)3.59241845
50sphingomyelin metabolic process (GO:0006684)3.57167466
51regulation of keratinocyte differentiation (GO:0045616)3.53664050
52male meiosis I (GO:0007141)3.48257920
53chromosome organization involved in meiosis (GO:0070192)3.47975136
54monoubiquitinated protein deubiquitination (GO:0035520)3.39759205
55amino-acid betaine transport (GO:0015838)3.39073548
56carnitine transport (GO:0015879)3.39073548
57pyrimidine-containing compound transmembrane transport (GO:0072531)3.38075546
58keratinocyte development (GO:0003334)3.36612397
59Golgi transport vesicle coating (GO:0048200)3.36488988
60COPI coating of Golgi vesicle (GO:0048205)3.36488988
61tight junction assembly (GO:0070830)3.35938115
62ventricular system development (GO:0021591)3.34110039
63cell-substrate junction assembly (GO:0007044)3.29886613
64hepatocyte apoptotic process (GO:0097284)3.24717272
65iron ion import (GO:0097286)3.23867807
66intestinal epithelial cell development (GO:0060576)3.20011723
67alditol metabolic process (GO:0019400)3.18819519
68meiotic nuclear division (GO:0007126)3.18445494
69bundle of His cell to Purkinje myocyte communication (GO:0086069)3.17813912
70desmosome organization (GO:0002934)3.15885833
71chemical homeostasis within a tissue (GO:0048875)3.14232097
72epithelial cell differentiation involved in prostate gland development (GO:0060742)3.10541821
73genitalia morphogenesis (GO:0035112)3.09849111
74positive regulation of keratinocyte differentiation (GO:0045618)3.07669441
75gap junction assembly (GO:0016264)3.02304233
76primary alcohol catabolic process (GO:0034310)3.00245979
77cell recognition (GO:0008037)3.00025653
78multicellular organismal reproductive process (GO:0048609)3.00017908
79COPII vesicle coating (GO:0048208)2.97942727
80regulation of inclusion body assembly (GO:0090083)2.95605875
81glycerol ether metabolic process (GO:0006662)2.94785626
82terpenoid biosynthetic process (GO:0016114)2.94162120
83quaternary ammonium group transport (GO:0015697)2.93733324
84chaperone-mediated protein complex assembly (GO:0051131)2.91047836
85cell adhesion mediated by integrin (GO:0033627)2.90584556
86protein localization to endosome (GO:0036010)2.88665412
87glycerol metabolic process (GO:0006071)2.87810607
88auditory receptor cell differentiation (GO:0042491)2.86758943
89sexual reproduction (GO:0019953)2.85361320
90gene silencing by RNA (GO:0031047)2.84759477
91positive regulation of epidermis development (GO:0045684)2.84155711
92meiotic cell cycle (GO:0051321)2.84071207
93carnitine transmembrane transport (GO:1902603)2.83154267
94regulation of transforming growth factor beta1 production (GO:0032908)2.82406292
95meiosis I (GO:0007127)2.82399637
96cellular glucuronidation (GO:0052695)2.81604738
97regulation of metalloenzyme activity (GO:0048552)2.73135081
98branching involved in mammary gland duct morphogenesis (GO:0060444)2.73093037
99epithelial cell-cell adhesion (GO:0090136)2.72471590
100polyol catabolic process (GO:0046174)2.70637643
101neutrophil activation involved in immune response (GO:0002283)2.70306991
102positive regulation of glycoprotein metabolic process (GO:1903020)2.70051099
103negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.70042870
104nuclear pore complex assembly (GO:0051292)2.66162985
105columnar/cuboidal epithelial cell development (GO:0002066)2.65496740
106ether metabolic process (GO:0018904)2.64828878
107drug transmembrane transport (GO:0006855)2.64799801
108membrane budding (GO:0006900)2.63844992
109sulfate transmembrane transport (GO:1902358)2.63657757
110vitamin transmembrane transport (GO:0035461)2.61623505
111glucuronate metabolic process (GO:0019585)2.59787678
112uronic acid metabolic process (GO:0006063)2.59787678
113regulation of vitamin metabolic process (GO:0030656)2.59289990
114protein autoprocessing (GO:0016540)2.58406639
115transcytosis (GO:0045056)2.57083218
116dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.56988854
117oligosaccharide biosynthetic process (GO:0009312)2.56874118
118spermatid nucleus differentiation (GO:0007289)2.56363859
119regulation of transforming growth factor beta2 production (GO:0032909)2.56295034
120nucleotide-sugar biosynthetic process (GO:0009226)2.55919116
121peptide catabolic process (GO:0043171)2.55576606
122microtubule depolymerization (GO:0007019)2.55375482
123renal filtration (GO:0097205)2.55167212
124positive regulation of glycoprotein biosynthetic process (GO:0010560)2.53417333
125calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.53097974
126cellular response to arsenic-containing substance (GO:0071243)2.52852360
127antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.52214418
128negative regulation of glycoprotein biosynthetic process (GO:0010561)2.51937152
129angiotensin maturation (GO:0002003)2.51375871
130chromosome condensation (GO:0030261)2.51034411
131regulation of microtubule-based movement (GO:0060632)2.50684165
132renal system development (GO:0072001)2.48070496
133regulation of transforming growth factor beta production (GO:0071634)2.47807838
134regulation of water loss via skin (GO:0033561)2.47591213
135regulation of epidermal cell differentiation (GO:0045604)2.47226126
136amyloid precursor protein catabolic process (GO:0042987)2.47186988
137* O-glycan processing (GO:0016266)2.47132663
138peptidyl-tyrosine autophosphorylation (GO:0038083)2.45832486
139antigen processing and presentation of endogenous antigen (GO:0019883)2.45344179
140epidermis development (GO:0008544)2.45023478
141negative regulation of cell fate specification (GO:0009996)2.44841765
142negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.44479647
143drug transport (GO:0015893)2.43525472
144multicellular organismal development (GO:0007275)2.43236305
145skin morphogenesis (GO:0043589)2.43149685
146cellular response to vitamin D (GO:0071305)2.43006177
147flavonoid metabolic process (GO:0009812)2.41060131
148intermediate filament organization (GO:0045109)2.40960785
149negative regulation of humoral immune response (GO:0002921)2.40329289
150microtubule severing (GO:0051013)2.40246094
151keratinocyte differentiation (GO:0030216)2.39183348
152ethanol metabolic process (GO:0006067)2.38705995
153ventricular cardiac muscle cell action potential (GO:0086005)2.38399496
154regulation of cellular extravasation (GO:0002691)2.38055151
155amyloid precursor protein metabolic process (GO:0042982)2.37900185
156activation of Rac GTPase activity (GO:0032863)2.37509472
157left/right pattern formation (GO:0060972)2.36848492
158transepithelial transport (GO:0070633)2.35849351
159cell-cell junction assembly (GO:0007043)2.34269964
160digestion (GO:0007586)2.32231436
161filopodium assembly (GO:0046847)2.31466780
162regulation of epidermis development (GO:0045682)2.30617295
163natural killer cell mediated cytotoxicity (GO:0042267)2.30127536
164natural killer cell mediated immunity (GO:0002228)2.30127536
165endosome organization (GO:0007032)2.29892673
166early endosome to late endosome transport (GO:0045022)2.29700490
167glandular epithelial cell differentiation (GO:0002067)2.29332886
168growth hormone receptor signaling pathway (GO:0060396)2.29255316
169antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.28721347
170antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.28721347
171regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.28672354
172UDP-N-acetylglucosamine metabolic process (GO:0006047)2.27800250
173DNA packaging (GO:0006323)2.27713310
174diol metabolic process (GO:0034311)2.27385963
175ectoderm development (GO:0007398)2.25554552
176excretion (GO:0007588)2.25408282
177maintenance of gastrointestinal epithelium (GO:0030277)2.25072119
178calcium ion-dependent exocytosis (GO:0017156)2.23683157
179intestinal absorption (GO:0050892)2.22348339
180fusion of sperm to egg plasma membrane (GO:0007342)10.9303933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.54591454
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.40695247
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.16616004
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.11956573
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.89801485
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.63060105
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.43021387
8SOX2_27498859_Chip-Seq_STOMACH_Mouse2.29064407
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.22478087
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22414511
11GATA4_25053715_ChIP-Seq_YYC3_Human2.08270225
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.07722630
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02469882
14FOXO3_23340844_ChIP-Seq_DLD1_Human1.99335455
15ZNF263_19887448_ChIP-Seq_K562_Human1.98301666
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.95879547
17GATA6_25053715_ChIP-Seq_YYC3_Human1.90752521
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89518410
19AR_21909140_ChIP-Seq_LNCAP_Human1.81581932
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.79168997
21RUNX1_27514584_Chip-Seq_MCF-7_Human1.73254685
22PPAR_26484153_Chip-Seq_NCI-H1993_Human1.68750732
23* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62865655
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60780791
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60346537
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.60186051
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.60186051
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.55057171
29* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.53973388
30CLOCK_20551151_ChIP-Seq_293T_Human1.49710353
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44614651
32* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.40941237
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39839258
34ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38795964
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37822850
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37478543
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34758674
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34641063
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.33987407
40STAT1_17558387_ChIP-Seq_HELA_Human1.33141144
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31893501
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.31597307
43KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31112491
44SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30435847
45KLF5_25053715_ChIP-Seq_YYC3_Human1.28809872
46CDX2_20551321_ChIP-Seq_CACO-2_Human1.28414907
47FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28009762
48KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25719885
49CHD1_26751641_Chip-Seq_LNCaP_Human1.23814850
50ELF5_23300383_ChIP-Seq_T47D_Human1.23465948
51* FOXA1_25552417_ChIP-Seq_VCAP_Human1.20211232
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20008584
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19927596
54FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19761979
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.18209660
56FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17258719
57CDX2_22108803_ChIP-Seq_LS180_Human1.17033860
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15502300
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15006141
60ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14893295
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.14704933
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13502309
63FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.12867428
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12246662
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11779625
66JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11678178
67* SOX2_20726797_ChIP-Seq_SW620_Human1.10036530
68ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09197656
69* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07753414
70P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07353334
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06683035
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05346579
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05325743
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04906397
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.03024401
76CJUN_26792858_Chip-Seq_BT549_Human1.02159802
77CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02045980
78ATF3_27146783_Chip-Seq_COLON_Human1.01403567
79* IRF8_27001747_Chip-Seq_BMDM_Mouse1.01299851
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.00396902
81EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99871027
82TCF4_18268006_ChIP-ChIP_LS174T_Human0.98750144
83VDR_24787735_ChIP-Seq_THP-1_Human0.98710058
84GATA1_22025678_ChIP-Seq_K562_Human0.96364767
85* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96245198
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95399721
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94480009
88JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94240652
89* GATA3_24758297_ChIP-Seq_MCF-7_Human0.93388221
90PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93146827
91AHR_22903824_ChIP-Seq_MCF-7_Human0.92107358
92BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91724935
93WDR5_24793694_ChIP-Seq_LNCAP_Human0.91436085
94* TP63_23658742_ChIP-Seq_EP156T_Human0.90481311
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90234307
96GATA1_26923725_Chip-Seq_HPCs_Mouse0.89639459
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89282736
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88598394
99GATA3_21867929_ChIP-Seq_CD8_Mouse0.88235328
100PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88117466
101P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88071231
102ZNF274_21170338_ChIP-Seq_K562_Hela0.87518264
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86102179
104ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.85753535
105CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85752507
106SOX2_22085726_ChIP-Seq_NPCs_Mouse0.85746655
107EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85651447
108SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85470445
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84092195
110PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84044536
111RACK7_27058665_Chip-Seq_MCF-7_Human0.83886538
112MYB_26560356_Chip-Seq_TH2_Human0.83615708
113ERG_20517297_ChIP-Seq_VCAP_Human0.83543210
114IRF8_21731497_ChIP-ChIP_J774_Mouse0.83162016
115FOXA2_19822575_ChIP-Seq_HepG2_Human0.82464333
116VDR_24763502_ChIP-Seq_THP-1_Human0.82462158
117TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82341776
118* TP63_22573176_ChIP-Seq_HFKS_Human0.82318149
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82148220
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81948515
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80847436
122PPARA_22158963_ChIP-Seq_LIVER_Mouse0.80710711
123NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80674479
124SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79422823
125UBF1/2_26484160_Chip-Seq_HMECs_Human0.79161348
126PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79078852
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78978062
128GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.78972845
129TBX20_22328084_ChIP-Seq_HEART_Mouse0.78870286
130TBX20_22080862_ChIP-Seq_HEART_Mouse0.78870286
131LXR_22158963_ChIP-Seq_LIVER_Mouse0.78717589
132STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78588815
133IRF8_22096565_ChIP-ChIP_GC-B_Human0.78264943
134NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77447719
135RUNX1_22412390_ChIP-Seq_EML_Mouse0.75066190
136TCF7_22412390_ChIP-Seq_EML_Mouse0.71430299
137CTNNB1_20460455_ChIP-Seq_HCT116_Human0.70799605
138MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.65155957

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.75413359
2MP0010234_abnormal_vibrissa_follicle5.02224111
3MP0004264_abnormal_extraembryonic_tissu3.08103734
4MP0003300_gastrointestinal_ulcer2.69338381
5* MP0003698_abnormal_male_reproductive2.62724444
6* MP0001929_abnormal_gametogenesis2.57431855
7MP0002796_impaired_skin_barrier2.36230033
8MP0010352_gastrointestinal_tract_polyps2.23461298
9MP0001666_abnormal_nutrient_absorption2.09567476
10MP0000537_abnormal_urethra_morphology2.08723982
11MP0005409_darkened_coat_color1.96756229
12MP0001873_stomach_inflammation1.85214911
13MP0010678_abnormal_skin_adnexa1.84534163
14MP0003191_abnormal_cellular_cholesterol1.84415910
15MP0009780_abnormal_chondrocyte_physiolo1.81447300
16MP0003806_abnormal_nucleotide_metabolis1.79647810
17MP0001849_ear_inflammation1.73627397
18MP0002166_altered_tumor_susceptibility1.70625737
19MP0001881_abnormal_mammary_gland1.70256658
20* MP0001765_abnormal_ion_homeostasis1.69473615
21MP0008877_abnormal_DNA_methylation1.68774239
22MP0005377_hearing/vestibular/ear_phenot1.65634531
23MP0003878_abnormal_ear_physiology1.65634531
24MP0002210_abnormal_sex_determination1.62986798
25MP0005360_urolithiasis1.56166393
26MP0004381_abnormal_hair_follicle1.54509850
27MP0001216_abnormal_epidermal_layer1.54195692
28MP0005501_abnormal_skin_physiology1.52157218
29MP0003566_abnormal_cell_adhesion1.52010864
30MP0002254_reproductive_system_inflammat1.51499231
31MP0003705_abnormal_hypodermis_morpholog1.49550483
32MP0002138_abnormal_hepatobiliary_system1.47988210
33MP0000762_abnormal_tongue_morphology1.47762610
34* MP0001145_abnormal_male_reproductive1.46313950
35MP0000678_abnormal_parathyroid_gland1.46233196
36MP0009643_abnormal_urine_homeostasis1.46217944
37MP0002006_tumorigenesis1.44238546
38* MP0002161_abnormal_fertility/fecundity1.41063750
39MP0002282_abnormal_trachea_morphology1.39630009
40MP0003866_abnormal_defecation1.39317812
41* MP0004019_abnormal_vitamin_homeostasis1.37893253
42MP0010155_abnormal_intestine_physiology1.36847055
43MP0003453_abnormal_keratinocyte_physiol1.35844135
44MP0002136_abnormal_kidney_physiology1.35806618
45MP0004947_skin_inflammation1.35377418
46MP0002098_abnormal_vibrissa_morphology1.34884357
47MP0005076_abnormal_cell_differentiation1.33669853
48MP0000490_abnormal_crypts_of1.33448168
49MP0005451_abnormal_body_composition1.33236526
50MP0008004_abnormal_stomach_pH1.30472320
51MP0002060_abnormal_skin_morphology1.29661685
52MP0008260_abnormal_autophagy1.24859208
53MP0002653_abnormal_ependyma_morphology1.24450911
54MP0002877_abnormal_melanocyte_morpholog1.24014442
55MP0004043_abnormal_pH_regulation1.23948818
56MP0000383_abnormal_hair_follicle1.22648935
57* MP0000653_abnormal_sex_gland1.22575672
58MP0008875_abnormal_xenobiotic_pharmacok1.22422438
59MP0001663_abnormal_digestive_system1.20093914
60MP0005085_abnormal_gallbladder_physiolo1.18028148
61MP0000627_abnormal_mammary_gland1.17421623
62MP0005365_abnormal_bile_salt1.15399596
63MP0000377_abnormal_hair_follicle1.14233169
64* MP0005636_abnormal_mineral_homeostasis1.14208221
65MP0006054_spinal_hemorrhage1.13958718
66MP0005408_hypopigmentation1.13789146
67MP0005166_decreased_susceptibility_to1.13328982
68MP0002277_abnormal_respiratory_mucosa1.12968670
69MP0003436_decreased_susceptibility_to1.05252512
70MP0003941_abnormal_skin_development1.05201403
71MP0003693_abnormal_embryo_hatching1.04701441
72MP0003724_increased_susceptibility_to1.02943969
73MP0005381_digestive/alimentary_phenotyp1.02285778
74MP0000538_abnormal_urinary_bladder1.01925767
75MP0000462_abnormal_digestive_system1.01858260
76MP0000858_altered_metastatic_potential1.00826459
77MP0001958_emphysema0.97459773
78MP0000477_abnormal_intestine_morphology0.91715177
79MP0009278_abnormal_bone_marrow0.91665762
80MP0005023_abnormal_wound_healing0.91636941
81MP0000465_gastrointestinal_hemorrhage0.90602617
82MP0002132_abnormal_respiratory_system0.90581829
83MP0005058_abnormal_lysosome_morphology0.88741966
84MP0005275_abnormal_skin_tensile0.87609445
85MP0001664_abnormal_digestion0.86739613
86MP0000367_abnormal_coat/_hair0.86093702
87MP0010771_integument_phenotype0.85339528
88MP0000566_synostosis0.84074793
89MP0003045_fibrosis0.83887180
90MP0009785_altered_susceptibility_to0.81935064
91MP0005025_abnormal_response_to0.81460512
92MP0005332_abnormal_amino_acid0.81331585
93MP0001756_abnormal_urination0.80579781
94MP0009840_abnormal_foam_cell0.80203127
95MP0003075_altered_response_to0.80107999
96MP0001835_abnormal_antigen_presentation0.78949172
97MP0001845_abnormal_inflammatory_respons0.78702615
98MP0005164_abnormal_response_to0.78082615
99MP0002234_abnormal_pharynx_morphology0.78024294
100MP0003303_peritoneal_inflammation0.77912831
101MP0002896_abnormal_bone_mineralization0.77585303
102MP0002396_abnormal_hematopoietic_system0.77187951
103MP0005220_abnormal_exocrine_pancreas0.77000463
104MP0005165_increased_susceptibility_to0.76543364
105MP0002909_abnormal_adrenal_gland0.75550489
106MP0005623_abnormal_meninges_morphology0.75092147
107MP0002405_respiratory_system_inflammati0.74400392
108MP0010307_abnormal_tumor_latency0.74259074
109MP0005083_abnormal_biliary_tract0.73836410
110MP0003252_abnormal_bile_duct0.72656542
111MP0004272_abnormal_basement_membrane0.72596678
112MP0000427_abnormal_hair_cycle0.71987327
113MP0005310_abnormal_salivary_gland0.71896841
114MP0000470_abnormal_stomach_morphology0.71868324
115MP0001545_abnormal_hematopoietic_system0.71819595
116MP0005397_hematopoietic_system_phenotyp0.71819595
117MP0003868_abnormal_feces_composition0.71668097
118MP0003091_abnormal_cell_migration0.70848536
119MP0002009_preneoplasia0.70817445
120MP0006082_CNS_inflammation0.70752849
121MP0000613_abnormal_salivary_gland0.69624469
122MP0005075_abnormal_melanosome_morpholog0.67765358
123MP0001191_abnormal_skin_condition0.67653168
124MP0005248_abnormal_Harderian_gland0.66420440
125MP0002139_abnormal_hepatobiliary_system0.65937312
126MP0005666_abnormal_adipose_tissue0.65749475
127MP0003183_abnormal_peptide_metabolism0.65734259
128MP0002148_abnormal_hypersensitivity_rea0.65273341
129MP0009931_abnormal_skin_appearance0.65114175
130MP0003448_altered_tumor_morphology0.64805882
131MP0000467_abnormal_esophagus_morphology0.64801977
132MP0000579_abnormal_nail_morphology0.64149540
133MP0002135_abnormal_kidney_morphology0.62561310
134MP0001851_eye_inflammation0.62410468
135MP0002928_abnormal_bile_duct0.62394758
136MP0004782_abnormal_surfactant_physiolog0.60502208
137MP0001533_abnormal_skeleton_physiology0.60418634

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.72958805
2Absent/shortened dynein arms (HP:0200106)8.63479922
3Dynein arm defect of respiratory motile cilia (HP:0012255)8.63479922
4Abnormal respiratory motile cilium physiology (HP:0012261)6.64744246
5Chronic bronchitis (HP:0004469)6.50174983
6Nasal polyposis (HP:0100582)5.96810162
7Abnormal respiratory epithelium morphology (HP:0012253)5.88139520
8Abnormal respiratory motile cilium morphology (HP:0005938)5.88139520
9Rhinitis (HP:0012384)5.68772539
10Abnormal ciliary motility (HP:0012262)5.18840899
11Abnormality of the nasal mucosa (HP:0000433)4.87205860
12Infertility (HP:0000789)4.41264673
13Abnormality of nail color (HP:0100643)4.30453072
14Bronchiectasis (HP:0002110)3.93230746
15Thick nail (HP:0001805)3.87953232
16Bronchitis (HP:0012387)3.82273393
17Milia (HP:0001056)3.80222229
18Lip pit (HP:0100267)3.68384948
19Tubular atrophy (HP:0000092)3.66076328
20Abnormality of chloride homeostasis (HP:0011422)3.61112797
21Onycholysis (HP:0001806)3.49795151
22Tubulointerstitial fibrosis (HP:0005576)3.34238635
23Gout (HP:0001997)3.30127474
24Right ventricular cardiomyopathy (HP:0011663)3.28833586
25Hyperactive renin-angiotensin system (HP:0000841)3.13934398
26Male infertility (HP:0003251)3.08244134
27Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.06940188
28Fragile nails (HP:0001808)2.88899186
29* Abnormality of renal excretion (HP:0011036)2.82246883
30Popliteal pterygium (HP:0009756)2.81936276
31Pili torti (HP:0003777)2.81797013
32Plantar hyperkeratosis (HP:0007556)2.81454912
33Abnormality of the renal medulla (HP:0100957)2.80636299
34Ridged nail (HP:0001807)2.79750635
35Sparse eyelashes (HP:0000653)2.75035810
36Tubulointerstitial nephritis (HP:0001970)2.74164976
37Tubulointerstitial abnormality (HP:0001969)2.71979863
38Abnormal urine output (HP:0012590)2.69116044
39Polyuria (HP:0000103)2.64313643
40Atrophic scars (HP:0001075)2.62853713
41Curly hair (HP:0002212)2.51036879
42Nephronophthisis (HP:0000090)2.50323218
43Micronodular cirrhosis (HP:0001413)2.49245578
44Amelogenesis imperfecta (HP:0000705)2.47835361
45Hyperuricemia (HP:0002149)2.46602141
46Increased purine levels (HP:0004368)2.46602141
47Interstitial pulmonary disease (HP:0006530)2.45949323
48Periodontitis (HP:0000704)2.44662913
49Cheilitis (HP:0100825)2.43039229
50* Hypoplasia of dental enamel (HP:0006297)2.41463065
51Hypokalemic alkalosis (HP:0001949)2.38420236
52Recurrent sinusitis (HP:0011108)2.37850185
53Abnormality of the salivary glands (HP:0010286)2.37134421
54Fat malabsorption (HP:0002630)2.35409199
55Pterygium (HP:0001059)2.31614261
56Decreased circulating renin level (HP:0003351)2.30389160
57Recurrent otitis media (HP:0000403)2.29824426
58Abnormal drinking behavior (HP:0030082)2.29742174
59Polydipsia (HP:0001959)2.29742174
60Hypotrichosis (HP:0001006)2.28191081
61Rectal prolapse (HP:0002035)2.26867416
62Breast carcinoma (HP:0003002)2.24577731
63Flat acetabular roof (HP:0003180)2.19851363
64Abnormality of renin-angiotensin system (HP:0000847)2.19019580
65Abnormality of purine metabolism (HP:0004352)2.16219843
66Premature loss of primary teeth (HP:0006323)2.16181583
67Abnormality of the renal cortex (HP:0011035)2.15921786
68Abnormality of monocarboxylic acid metabolism (HP:0010996)2.15568454
69Metabolic alkalosis (HP:0200114)2.13768311
70Eczematoid dermatitis (HP:0000976)2.12528797
71Renal salt wasting (HP:0000127)2.12297082
72Pustule (HP:0200039)2.10188449
73Septate vagina (HP:0001153)2.09234268
74Tetany (HP:0001281)2.06896819
75Aplasia cutis congenita (HP:0001057)2.05234570
76Recurrent bronchitis (HP:0002837)2.03672333
77Stage 5 chronic kidney disease (HP:0003774)2.00844578
78Abnormal spermatogenesis (HP:0008669)2.00034457
79Recurrent bacterial skin infections (HP:0005406)1.99340958
80Ankyloglossia (HP:0010296)1.98398288
81Xerostomia (HP:0000217)1.98301154
82Chronic diarrhea (HP:0002028)1.97661530
83Palpitations (HP:0001962)1.97543412
84Steatorrhea (HP:0002570)1.97273512
85Selective tooth agenesis (HP:0001592)1.97202452
86Hoarse voice (HP:0001609)1.96139029
87Malnutrition (HP:0004395)1.94996921
88Abdominal distention (HP:0003270)1.92077820
89Hyperaldosteronism (HP:0000859)1.90799250
90Advanced eruption of teeth (HP:0006288)1.90030052
91Proximal tubulopathy (HP:0000114)1.89631078
92Natal tooth (HP:0000695)1.89156943
93Sparse scalp hair (HP:0002209)1.86719175
94Hyperkalemia (HP:0002153)1.86591617
95Hypomagnesemia (HP:0002917)1.85803019
96Subacute progressive viral hepatitis (HP:0006572)1.83493987
97Erythema (HP:0010783)1.82410954
98Gingivitis (HP:0000230)1.80990886
99Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.80559031
100Abnormal biliary tract morphology (HP:0012440)1.79666772
101Hyperparathyroidism (HP:0000843)1.79569885
102Intrahepatic cholestasis (HP:0001406)1.79199643
103Vacuolated lymphocytes (HP:0001922)1.78960096
104Skin ulcer (HP:0200042)1.78671602
105Fragile skin (HP:0001030)1.78464577
106Abnormality of the axillary hair (HP:0100134)1.76112688
107Abnormality of secondary sexual hair (HP:0009888)1.76112688
108Hyponatremia (HP:0002902)1.74015500
109Hand muscle atrophy (HP:0009130)1.73643322
110Nail dystrophy (HP:0008404)1.73610212
111Blepharitis (HP:0000498)1.73426280
112Abnormal hair laboratory examination (HP:0003328)1.71996664
113Hypoplastic labia majora (HP:0000059)1.71530415
114Recurrent abscess formation (HP:0002722)1.71375421
115Urticaria (HP:0001025)1.70907270
116Palmoplantar hyperkeratosis (HP:0000972)1.70489341
117Biliary tract neoplasm (HP:0100574)1.70310912
118Absent eyelashes (HP:0000561)1.70062898
119Broad face (HP:0000283)1.69680089
120Spinal cord compression (HP:0002176)1.69573386
121Dry hair (HP:0011359)1.69425425
122Dehydration (HP:0001944)1.68196240
123Abnormality of glutamine family amino acid metabolism (HP:0010902)1.68112545
124Increased circulating renin level (HP:0000848)1.66601349
125Azoospermia (HP:0000027)1.66304889
126Abnormality of the gastric mucosa (HP:0004295)1.65098079
127Delayed epiphyseal ossification (HP:0002663)1.64576595
128Metaphyseal cupping (HP:0003021)1.64113771
129Glomerulosclerosis (HP:0000096)1.61570828
130Esophageal varix (HP:0002040)1.61281277
131Protuberant abdomen (HP:0001538)1.59634776
132Abnormality of proline metabolism (HP:0010907)1.58349768
133Hydroxyprolinuria (HP:0003080)1.58349768
134Abnormality of the distal phalanges of the toes (HP:0010182)1.57056930
135Absent frontal sinuses (HP:0002688)1.56556625
13611 pairs of ribs (HP:0000878)1.54928809
137Osteolytic defects of the hand bones (HP:0009699)1.53960760
138Osteolytic defects of the phalanges of the hand (HP:0009771)1.53960760
139Palmar hyperkeratosis (HP:0010765)1.51672004
140Short nail (HP:0001799)1.50678272
141Alopecia of scalp (HP:0002293)1.49665486
142Abnormal blistering of the skin (HP:0008066)1.48595960
143Abnormality of small intestinal villus morphology (HP:0011472)1.47655821
144Villous atrophy (HP:0011473)1.47655821
145Abnormality of magnesium homeostasis (HP:0004921)1.47516121
146Abnormality of the labia majora (HP:0012881)1.46968598
147Glucose intolerance (HP:0000833)1.46860702
148Epiphyseal dysplasia (HP:0002656)1.45205619
149Hypodontia (HP:0000668)1.43906192
150Short ribs (HP:0000773)1.42631631
151Ileus (HP:0002595)1.42582815
152Woolly hair (HP:0002224)1.41029281
153Choroideremia (HP:0001139)1.40848986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.65134780
2PDK36.65134780
3PDK24.51182010
4EPHA24.20750484
5TESK13.84315849
6WNK43.53595255
7STK393.00970588
8STK242.82383411
9MST42.79714051
10MAP3K122.62905700
11MST1R2.21138317
12BMPR21.94900930
13LMTK21.91450756
14FRK1.89531721
15SMG11.63164814
16STK38L1.56146976
17PRKD31.53820630
18STK101.50824369
19EEF2K1.49897529
20ICK1.42488583
21LATS11.38778191
22STK31.37787789
23PTK61.31106395
24TRIB31.27671588
25PTK2B1.24874668
26ERN11.22227701
27NEK21.19795273
28SCYL21.19550088
29FER1.15513728
30EPHB11.14633923
31MAP2K21.12897273
32SIK31.12036321
33PAK41.07018197
34OXSR11.03246860
35ACVR1B1.03140082
36MAP3K31.01181742
37LRRK21.00980401
38MAP3K21.00164000
39STK380.99948110
40NEK60.98887374
41IRAK40.96162158
42DYRK1B0.95170493
43RPS6KB20.93418837
44YES10.93151597
45RIPK10.92517881
46PTK20.87774783
47ARAF0.85771931
48IRAK20.83700674
49MAP3K90.78789467
50MAPKAPK30.75342874
51CDK60.73521426
52NEK90.73331500
53MET0.71937087
54WNK30.71923873
55PRKG20.71478816
56SIK10.70080637
57IRAK10.68906662
58TRPM70.68435577
59PDK10.67603924
60WNK10.64831661
61FGFR30.64000931
62PKN20.63091064
63RIPK40.62904004
64IKBKE0.62514036
65TTK0.60974691
66TBK10.59445177
67PDGFRB0.58563106
68PNCK0.58286732
69EIF2AK30.56917555
70CDK120.56701893
71DDR20.56393253
72MYLK0.56121622
73ZAP700.55142312
74CSF1R0.53962919
75PRKD20.52326561
76TGFBR20.51657133
77ILK0.49765607
78MATK0.49179427
79JAK10.48064973
80IKBKB0.47732869
81MAP3K130.46020016
82CAMK1G0.45962220
83BMX0.45113932
84MAP3K60.42780862
85MAP3K80.42565597
86SGK30.42426676
87TTN0.42143539
88CSK0.41718201
89MTOR0.40968420
90JAK30.40692296
91PIM20.39415325
92MAPK150.39091007
93CHUK0.37317629
94BRSK20.36871629
95PDPK10.36756574
96BCR0.35764142
97HIPK20.35547504
98EPHB20.35061931
99NUAK10.34428474
100MAP4K10.34280501
101TYRO30.34159706
102PRKCI0.34022735
103TRIM280.33422746
104FGFR40.33192353
105KSR20.32958839
106RPS6KA40.32652212
107EPHA30.32600725
108RPS6KA20.32222662
109CDC42BPA0.32173780
110MAPKAPK20.31509579
111CAMK1D0.31207223
112PRKAA20.30654905
113FGR0.30407035
114NME20.29288142
115RET0.29269888
116AURKB0.28836943
117PASK0.28018583
118MAP2K60.27790284
119PIK3CA0.27728937
120PIM10.27697009
121EGFR0.27674392
122GSK3A0.26954260
123PAK20.26534684
124MELK0.25460248
125TAOK10.24876605
126EIF2AK10.24757858
127TYK20.23938840
128DYRK30.23513167
129ERBB30.20147672
130GRK60.19976983
131PAK10.19466063
132ERBB20.19200156
133RPS6KA10.18521342
134MAP3K140.18517819
135PLK40.17527820
136MAP3K10.16977550
137IRAK30.16361699
138CHEK10.15916878

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049782.92939634
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.85734277
3Pyruvate metabolism_Homo sapiens_hsa006202.77696492
4Fatty acid biosynthesis_Homo sapiens_hsa000612.63245148
5Pentose phosphate pathway_Homo sapiens_hsa000302.34416498
6Protein digestion and absorption_Homo sapiens_hsa049742.25353198
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.19220466
8Propanoate metabolism_Homo sapiens_hsa006402.13846430
9Fat digestion and absorption_Homo sapiens_hsa049752.07582439
10Glycerolipid metabolism_Homo sapiens_hsa005611.94883075
11Renin-angiotensin system_Homo sapiens_hsa046141.94814588
12* Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.92629301
13Glutathione metabolism_Homo sapiens_hsa004801.90067539
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.83421675
15Vitamin digestion and absorption_Homo sapiens_hsa049771.79804436
16Sulfur metabolism_Homo sapiens_hsa009201.77250603
17Starch and sucrose metabolism_Homo sapiens_hsa005001.66341432
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62851425
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.57537115
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55729360
21Thyroid cancer_Homo sapiens_hsa052161.54286864
22Fructose and mannose metabolism_Homo sapiens_hsa000511.51810742
23Pancreatic secretion_Homo sapiens_hsa049721.48364273
24Phenylalanine metabolism_Homo sapiens_hsa003601.44618176
25Selenocompound metabolism_Homo sapiens_hsa004501.44366238
26Adherens junction_Homo sapiens_hsa045201.37675560
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.36789552
28ECM-receptor interaction_Homo sapiens_hsa045121.35800934
29Other glycan degradation_Homo sapiens_hsa005111.35118721
30Toxoplasmosis_Homo sapiens_hsa051451.33269968
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33139363
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.32534582
33Antigen processing and presentation_Homo sapiens_hsa046121.29107629
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.28945601
35Tight junction_Homo sapiens_hsa045301.28330534
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.27097548
37Legionellosis_Homo sapiens_hsa051341.26955108
38Small cell lung cancer_Homo sapiens_hsa052221.25826732
39Vitamin B6 metabolism_Homo sapiens_hsa007501.23056346
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22162164
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.15924049
42Caffeine metabolism_Homo sapiens_hsa002321.15808327
43Retinol metabolism_Homo sapiens_hsa008301.14800337
44Carbon metabolism_Homo sapiens_hsa012001.13614695
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11872166
46Linoleic acid metabolism_Homo sapiens_hsa005911.10965161
47Dorso-ventral axis formation_Homo sapiens_hsa043201.07254019
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05521827
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05174890
50Glucagon signaling pathway_Homo sapiens_hsa049221.01543344
51PPAR signaling pathway_Homo sapiens_hsa033201.01360912
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.00242960
53Endometrial cancer_Homo sapiens_hsa052130.98594027
54Bladder cancer_Homo sapiens_hsa052190.96639279
55Collecting duct acid secretion_Homo sapiens_hsa049660.95884549
56Thyroid hormone synthesis_Homo sapiens_hsa049180.95753700
57Type I diabetes mellitus_Homo sapiens_hsa049400.94340473
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92821055
59Fatty acid degradation_Homo sapiens_hsa000710.91531522
60Salmonella infection_Homo sapiens_hsa051320.89343270
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88898861
62Tyrosine metabolism_Homo sapiens_hsa003500.87833492
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86368686
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85658430
65Influenza A_Homo sapiens_hsa051640.83401372
66Acute myeloid leukemia_Homo sapiens_hsa052210.80297272
67Bile secretion_Homo sapiens_hsa049760.79350455
68Prostate cancer_Homo sapiens_hsa052150.78960875
69Renal cell carcinoma_Homo sapiens_hsa052110.76801709
70Graft-versus-host disease_Homo sapiens_hsa053320.75094890
71Amoebiasis_Homo sapiens_hsa051460.74688696
72Asthma_Homo sapiens_hsa053100.70689230
73TNF signaling pathway_Homo sapiens_hsa046680.70119038
74N-Glycan biosynthesis_Homo sapiens_hsa005100.69601633
75Arachidonic acid metabolism_Homo sapiens_hsa005900.68819923
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67908445
77Shigellosis_Homo sapiens_hsa051310.66818501
78Chronic myeloid leukemia_Homo sapiens_hsa052200.65936178
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65841826
80Allograft rejection_Homo sapiens_hsa053300.65619129
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65542619
82Chemical carcinogenesis_Homo sapiens_hsa052040.65179770
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.65078779
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64439679
85Hepatitis C_Homo sapiens_hsa051600.63065551
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62465139
87Non-small cell lung cancer_Homo sapiens_hsa052230.61940976
88Autoimmune thyroid disease_Homo sapiens_hsa053200.61834634
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61520911
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60889447
91Biosynthesis of amino acids_Homo sapiens_hsa012300.60861096
92Leishmaniasis_Homo sapiens_hsa051400.59551193
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.58697389
94Vibrio cholerae infection_Homo sapiens_hsa051100.57704438
95Focal adhesion_Homo sapiens_hsa045100.57590505
96Fatty acid metabolism_Homo sapiens_hsa012120.57299221
97Inositol phosphate metabolism_Homo sapiens_hsa005620.57163145
98Galactose metabolism_Homo sapiens_hsa000520.57138631
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56597079
100Hippo signaling pathway_Homo sapiens_hsa043900.55517051
101ErbB signaling pathway_Homo sapiens_hsa040120.55166637
102VEGF signaling pathway_Homo sapiens_hsa043700.55112179
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.54954194
104Tuberculosis_Homo sapiens_hsa051520.53604102
105Hematopoietic cell lineage_Homo sapiens_hsa046400.53212588
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52456500
107Lysosome_Homo sapiens_hsa041420.51608469
108Sphingolipid metabolism_Homo sapiens_hsa006000.51145775
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51006610
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.51003876
111Staphylococcus aureus infection_Homo sapiens_hsa051500.50807349
112Proteoglycans in cancer_Homo sapiens_hsa052050.50768592
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50480175
114Arginine biosynthesis_Homo sapiens_hsa002200.48781161
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48757331
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.47750900
117Osteoclast differentiation_Homo sapiens_hsa043800.47629880
118Viral carcinogenesis_Homo sapiens_hsa052030.47425982
119Ether lipid metabolism_Homo sapiens_hsa005650.46709356
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46218068
121Endocytosis_Homo sapiens_hsa041440.43256454
122p53 signaling pathway_Homo sapiens_hsa041150.41682866
123HIF-1 signaling pathway_Homo sapiens_hsa040660.41544195
124Rheumatoid arthritis_Homo sapiens_hsa053230.40995433
125Histidine metabolism_Homo sapiens_hsa003400.40365923
126Malaria_Homo sapiens_hsa051440.40051376
127Pancreatic cancer_Homo sapiens_hsa052120.39252156
128Basal transcription factors_Homo sapiens_hsa030220.39233038
129Measles_Homo sapiens_hsa051620.37476740
130Folate biosynthesis_Homo sapiens_hsa007900.36842912
131Insulin resistance_Homo sapiens_hsa049310.36326523
132Apoptosis_Homo sapiens_hsa042100.36116917

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