GALNT5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane-bound polypeptide N-acetylgalactosaminyltransferase that is found in the Golgi. The encoded protein catalyzes the first step in the mucin-type O-glycosylation of Golgi proteins, transfering an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)6.21764631
2sequestering of extracellular ligand from receptor (GO:0035581)5.92363537
3skin morphogenesis (GO:0043589)5.80391233
4type B pancreatic cell proliferation (GO:0044342)5.68348836
5mesenchymal cell differentiation involved in kidney development (GO:0072161)5.24616988
6mesenchymal cell differentiation involved in renal system development (GO:2001012)5.24616988
7axon ensheathment in central nervous system (GO:0032291)5.24587061
8central nervous system myelination (GO:0022010)5.24587061
9cell adhesion mediated by integrin (GO:0033627)5.12695106
10chondrocyte proliferation (GO:0035988)5.00378051
11protein heterotrimerization (GO:0070208)4.95800747
12COPI coating of Golgi vesicle (GO:0048205)4.92806821
13Golgi transport vesicle coating (GO:0048200)4.92806821
14adhesion of symbiont to host cell (GO:0044650)4.88584748
15virion attachment to host cell (GO:0019062)4.88584748
16endodermal cell differentiation (GO:0035987)4.80675050
17detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.80039421
18detection of temperature stimulus involved in sensory perception (GO:0050961)4.80039421
19extracellular matrix assembly (GO:0085029)4.70798319
20hemidesmosome assembly (GO:0031581)4.66487051
21cellular response to vitamin (GO:0071295)4.60689004
22regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.58814158
23cell differentiation involved in metanephros development (GO:0072202)4.51867782
24uronic acid metabolic process (GO:0006063)4.51855966
25glucuronate metabolic process (GO:0019585)4.51855966
26detection of temperature stimulus (GO:0016048)4.51568790
27mesenchymal-epithelial cell signaling (GO:0060638)4.27435912
28endocardial cushion development (GO:0003197)4.26893620
29adhesion of symbiont to host (GO:0044406)4.19963035
30hypotonic response (GO:0006971)4.19634693
31substrate-dependent cell migration (GO:0006929)4.18434494
32extracellular fibril organization (GO:0043206)4.14741168
33neurofilament cytoskeleton organization (GO:0060052)4.14740552
34negative regulation of homotypic cell-cell adhesion (GO:0034111)4.14082139
35presynaptic membrane organization (GO:0097090)4.09897144
36peripheral nervous system neuron development (GO:0048935)4.08278052
37limb bud formation (GO:0060174)4.02348951
38regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.01652094
39positive regulation of osteoblast proliferation (GO:0033690)4.00922847
40neuronal action potential (GO:0019228)3.98466691
41adenosine metabolic process (GO:0046085)3.92786381
42cellular response to vitamin D (GO:0071305)3.91444546
43collagen metabolic process (GO:0032963)3.90115771
44bundle of His cell to Purkinje myocyte communication (GO:0086069)3.89878234
45extracellular regulation of signal transduction (GO:1900115)3.85934068
46extracellular negative regulation of signal transduction (GO:1900116)3.85934068
47maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.85480739
48cranial nerve morphogenesis (GO:0021602)3.85467382
49protein retention in ER lumen (GO:0006621)3.84569495
50metanephric mesenchyme development (GO:0072075)3.79787526
51mesodermal cell differentiation (GO:0048333)3.77470668
52cellular glucuronidation (GO:0052695)3.75385163
53regulation of platelet aggregation (GO:0090330)3.74541395
54fibril organization (GO:0097435)3.72386549
55COPII vesicle coating (GO:0048208)3.70900624
56collagen catabolic process (GO:0030574)3.70613334
57cell migration involved in heart development (GO:0060973)3.69415215
58negative regulation of smooth muscle cell migration (GO:0014912)3.66437102
59multicellular organismal macromolecule metabolic process (GO:0044259)3.66419092
60regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.65776371
61cell-substrate junction assembly (GO:0007044)3.63235881
62regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.57628482
63enteric nervous system development (GO:0048484)3.52963647
64muscle cell migration (GO:0014812)3.52929483
65nucleotide transmembrane transport (GO:1901679)3.52811918
66cell differentiation involved in kidney development (GO:0061005)3.49221826
67presynaptic membrane assembly (GO:0097105)3.48406865
68multicellular organismal metabolic process (GO:0044236)3.47444584
69multicellular organismal catabolic process (GO:0044243)3.44657480
70positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.43071114
71positive regulation of blood vessel endothelial cell migration (GO:0043536)3.39999222
72myelin maintenance (GO:0043217)3.38332296
73desmosome organization (GO:0002934)3.37633449
74mechanoreceptor differentiation (GO:0042490)3.35322718
75vesicle coating (GO:0006901)3.34389722
76cell migration involved in sprouting angiogenesis (GO:0002042)3.34032825
77negative regulation of osteoblast proliferation (GO:0033689)3.32070674
783-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.31249254
79purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.31249254
80blood vessel maturation (GO:0001955)3.29218232
81regulation of osteoblast proliferation (GO:0033688)3.27980376
82extracellular matrix disassembly (GO:0022617)3.27144668
83pericardium development (GO:0060039)3.26753968
84negative regulation of dendrite morphogenesis (GO:0050774)3.26527063
85regulation of heat generation (GO:0031650)3.26432622
86kidney mesenchyme development (GO:0072074)3.25662085
87mature B cell differentiation involved in immune response (GO:0002313)3.24180071
88detection of mechanical stimulus involved in sensory perception (GO:0050974)3.21303076
89negative regulation of glycogen biosynthetic process (GO:0045719)3.19887491
90regulation of cell communication by electrical coupling (GO:0010649)3.16286740
91regulation of metalloenzyme activity (GO:0048552)3.15735361
92kidney morphogenesis (GO:0060993)3.15260098
93positive regulation of endothelial cell apoptotic process (GO:2000353)3.13348218
94purine ribonucleotide transport (GO:0015868)3.12588125
95hyaluronan catabolic process (GO:0030214)3.11002929
96negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.10955413
97negative regulation of stem cell proliferation (GO:2000647)3.10651637
98negative regulation of chondrocyte differentiation (GO:0032331)3.10243093
99cellular response to interferon-alpha (GO:0035457)3.09137214
100regulation of extracellular matrix disassembly (GO:0010715)3.07347169
101barbed-end actin filament capping (GO:0051016)3.06710735
102heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.06155287
103regulation of integrin-mediated signaling pathway (GO:2001044)3.05640425
104apoptotic cell clearance (GO:0043277)3.05242575
105extracellular matrix organization (GO:0030198)3.04189506
106endothelial cell morphogenesis (GO:0001886)3.04039275
107negative regulation of biomineral tissue development (GO:0070168)3.03111256
108inner ear receptor cell differentiation (GO:0060113)3.03092450
109extracellular structure organization (GO:0043062)3.03032370
110protein hydroxylation (GO:0018126)3.03011661
111positive regulation of fibroblast migration (GO:0010763)3.02263628
112peptidyl-proline hydroxylation (GO:0019511)3.02212540
113negative regulation of axon extension involved in axon guidance (GO:0048843)3.02020076
114smooth muscle tissue development (GO:0048745)3.01395967
115regulation of pigment cell differentiation (GO:0050932)3.01237130
116negative regulation of protein localization to plasma membrane (GO:1903077)3.00743189
117mesenchymal cell differentiation (GO:0048762)2.97901380
118positive regulation of extracellular matrix organization (GO:1903055)2.97217190
119DNA damage induced protein phosphorylation (GO:0006975)2.96560654
120nucleotide-sugar biosynthetic process (GO:0009226)2.95550265
121protein localization to endosome (GO:0036010)2.95298993
122microtubule polymerization or depolymerization (GO:0031109)2.94614463
123L-fucose catabolic process (GO:0042355)2.91903272
124fucose catabolic process (GO:0019317)2.91903272
125L-fucose metabolic process (GO:0042354)2.91903272
126diterpenoid biosynthetic process (GO:0016102)2.91189106
127phasic smooth muscle contraction (GO:0014821)2.90393236
128wound healing, spreading of epidermal cells (GO:0035313)2.90206956
129regulation of relaxation of muscle (GO:1901077)2.90054292
130vascular endothelial growth factor signaling pathway (GO:0038084)2.89497732
131actin filament depolymerization (GO:0030042)2.89117418
132cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.87209202
133negative regulation of BMP signaling pathway (GO:0030514)2.87152167
134regulation of secondary heart field cardioblast proliferation (GO:0003266)2.87033685
135regulation of cardioblast proliferation (GO:0003264)2.87033685
136generation of neurons (GO:0048699)2.86899119
137midgut development (GO:0007494)2.84983505
138chondrocyte development (GO:0002063)2.84910937
139cerebral cortex radially oriented cell migration (GO:0021799)2.84890825
140phospholipid scrambling (GO:0017121)2.84287025
141behavioral response to pain (GO:0048266)2.84245597
142positive regulation of actin filament depolymerization (GO:0030836)2.84114387
143substrate adhesion-dependent cell spreading (GO:0034446)2.83291305
144negative regulation of heart rate (GO:0010459)2.83194641
145neuron fate specification (GO:0048665)2.82716403
146negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.82312699
147regulation of transforming growth factor beta1 production (GO:0032908)2.81564656
148regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.80910409
149sprouting angiogenesis (GO:0002040)2.80501606
150negative regulation of calcium ion transport into cytosol (GO:0010523)2.79019740
151dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.78810288
152regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.78797301
153negative regulation of fibroblast apoptotic process (GO:2000270)2.78545253
154nucleotide transport (GO:0006862)2.77483842
155positive regulation of action potential (GO:0045760)2.76476762
156cyclooxygenase pathway (GO:0019371)2.76068441
157iron ion import (GO:0097286)2.75157223
158response to pain (GO:0048265)2.74668828
159membrane raft organization (GO:0031579)2.74580741
160mitochondrial calcium ion homeostasis (GO:0051560)2.74386246
161cholesterol biosynthetic process (GO:0006695)2.73532392
162positive regulation of synaptic transmission, GABAergic (GO:0032230)2.73055611
163regulation of early endosome to late endosome transport (GO:2000641)2.70066506
164regulation of smooth muscle cell migration (GO:0014910)2.69398328
165urinary tract smooth muscle contraction (GO:0014848)2.67365612
166proline transport (GO:0015824)2.67259264
167regulation of plasminogen activation (GO:0010755)2.65371729
168wound healing (GO:0042060)2.65108145
169retinal ganglion cell axon guidance (GO:0031290)2.64978557
170myelin assembly (GO:0032288)2.64384689
171negative regulation of glycogen metabolic process (GO:0070874)2.64195767
172negative regulation of anoikis (GO:2000811)2.64173132
173positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.63645015
174UDP-N-acetylglucosamine metabolic process (GO:0006047)2.63642648
175dermatan sulfate biosynthetic process (GO:0030208)2.63517705
176outer ear morphogenesis (GO:0042473)2.63485443
177retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.62808790
178fucosylation (GO:0036065)2.61505256
179chondrocyte differentiation (GO:0002062)2.60596173
180negative regulation of complement activation (GO:0045916)2.58004369
181lung secretory cell differentiation (GO:0061140)2.57147042
182middle ear morphogenesis (GO:0042474)2.56641628
183pyrimidine-containing compound transmembrane transport (GO:0072531)2.56229962
184auditory receptor cell stereocilium organization (GO:0060088)2.55784585
185long-chain fatty acid biosynthetic process (GO:0042759)2.54910941
186inner ear receptor stereocilium organization (GO:0060122)2.52796304
187one-carbon compound transport (GO:0019755)2.52477275
188regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.51695288
189response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.48554608
190bone trabecula formation (GO:0060346)2.48397289
191water-soluble vitamin biosynthetic process (GO:0042364)2.47083324
192positive regulation of protein homodimerization activity (GO:0090073)2.46555906
193response to water (GO:0009415)2.46188796
194cranial nerve structural organization (GO:0021604)2.45413243
195positive regulation of steroid hormone secretion (GO:2000833)2.43725590
196adenine nucleotide transport (GO:0051503)2.42336468
197calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.39137941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.32023600
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.67701075
3GBX2_23144817_ChIP-Seq_PC3_Human3.91342602
4BRD4_25478319_ChIP-Seq_HGPS_Human3.55017066
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.26484428
6TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human3.06423051
7RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.92480529
8CJUN_26792858_Chip-Seq_BT549_Human2.91646155
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.76486944
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.73282381
11CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.70900621
12CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.51112525
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.50481835
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.46840610
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.46840610
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.43859372
17CLOCK_20551151_ChIP-Seq_293T_Human2.39770464
18* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25024074
19TAF15_26573619_Chip-Seq_HEK293_Human2.18615828
20TP53_16413492_ChIP-PET_HCT116_Human2.18148019
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.16513244
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15920558
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.13776474
24EP300_21415370_ChIP-Seq_HL-1_Mouse2.13249717
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13081287
26JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.10143869
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08784009
28AR_21572438_ChIP-Seq_LNCaP_Human2.05911175
29HIF1A_21447827_ChIP-Seq_MCF-7_Human2.05875107
30PPAR_26484153_Chip-Seq_NCI-H1993_Human2.01921990
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00554792
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.99666738
33JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.98174821
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.97417077
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.97311677
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94173422
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.89426003
38ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.88863432
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.88381853
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.87938081
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.87611218
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87439985
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85918595
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85641876
45FUS_26573619_Chip-Seq_HEK293_Human1.82279549
46P300_19829295_ChIP-Seq_ESCs_Human1.81705154
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.79494884
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75839327
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.72141741
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68253182
51SMAD4_21799915_ChIP-Seq_A2780_Human1.67612451
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66380694
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65149746
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.64910714
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64878134
56SALL4_18804426_ChIP-ChIP_XEN_Mouse1.63614492
57* CBX2_27304074_Chip-Seq_ESCs_Mouse1.63095441
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61613446
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61613446
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.61004507
61* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58731430
62VDR_22108803_ChIP-Seq_LS180_Human1.57513134
63AR_21909140_ChIP-Seq_LNCAP_Human1.57346407
64GATA1_19941826_ChIP-Seq_K562_Human1.57296185
65* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56696248
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.56328681
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55791039
68MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.53963961
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.53369974
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53228126
71FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.52639528
72TP53_22127205_ChIP-Seq_IMR90_Human1.51174283
73* SOX2_20726797_ChIP-Seq_SW620_Human1.50934233
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50493597
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50162460
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49717621
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49270917
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.48656578
79UBF1/2_26484160_Chip-Seq_HMECs_Human1.48336375
80EWS_26573619_Chip-Seq_HEK293_Human1.47292806
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46930419
82AHR_22903824_ChIP-Seq_MCF-7_Human1.44209251
83* TCF4_18268006_ChIP-ChIP_LS174T_Human1.43694851
84DROSHA_22980978_ChIP-Seq_HELA_Human1.42603075
85* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42288983
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42138163
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41758851
88* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41268341
89MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40137404
90* TP53_18474530_ChIP-ChIP_U2OS_Human1.39490853
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39182188
92SMC1_22415368_ChIP-Seq_MEFs_Mouse1.39104413
93AR_25329375_ChIP-Seq_VCAP_Human1.39044619
94* NANOG_18555785_Chip-Seq_ESCs_Mouse1.39032697
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37578224
96ATF3_27146783_Chip-Seq_COLON_Human1.36925540
97* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36453994
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36338438
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34375320
100EZH2_27294783_Chip-Seq_ESCs_Mouse1.34157484
101ESR2_21235772_ChIP-Seq_MCF-7_Human1.32799875
102CDX2_20551321_ChIP-Seq_CACO-2_Human1.32172488
103CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29194032
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.28583884
105NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.28519811
106* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28001711
107RNF2_27304074_Chip-Seq_NSC_Mouse1.27102371
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27000320
109P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26900241
110NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26867211
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26867211
112* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26119928
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24884694
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24626071
115RNF2_27304074_Chip-Seq_ESCs_Mouse1.24550875
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24031695
117SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23863864
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23562389
119SA1_22415368_ChIP-Seq_MEFs_Mouse1.23079269
120GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22847718
121* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22661968
122ESR1_21235772_ChIP-Seq_MCF-7_Human1.22519123
123TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22000881
124EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.21611256
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21440398
126P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21419582
127NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20838079
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19901244
129TAL1_26923725_Chip-Seq_HPCs_Mouse1.19584779
130EZH2_27294783_Chip-Seq_NPCs_Mouse1.18608032
131* E2F1_18555785_Chip-Seq_ESCs_Mouse1.18466259
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18360333
133CMYC_18555785_Chip-Seq_ESCs_Mouse1.17923863
134NFE2_27457419_Chip-Seq_LIVER_Mouse1.17603342
135* P53_22387025_ChIP-Seq_ESCs_Mouse1.17562958
136TP53_23651856_ChIP-Seq_MEFs_Mouse1.17079162
137FOXO3_23340844_ChIP-Seq_DLD1_Human1.16937867
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16833753
139STAT3_23295773_ChIP-Seq_U87_Human1.14002899
140ER_23166858_ChIP-Seq_MCF-7_Human1.13934120
141UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13851817
142CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13816866
143TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13807194
144KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12923451
145P300_18555785_Chip-Seq_ESCs_Mouse1.11636347
146SOX2_19829295_ChIP-Seq_ESCs_Human1.11582352
147NANOG_19829295_ChIP-Seq_ESCs_Human1.11582352
148POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11462985
149RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10975152
150GATA2_21666600_ChIP-Seq_HMVEC_Human1.09978949
151SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09777316
152TBX20_22080862_ChIP-Seq_HEART_Mouse1.09460347
153TBX20_22328084_ChIP-Seq_HEART_Mouse1.09460347
154* GATA2_19941826_ChIP-Seq_K562_Human1.08189575
155* TP63_23658742_ChIP-Seq_EP156T_Human1.06991238
156Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06917275
157PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.06800106
158TCF4_23295773_ChIP-Seq_U87_Human1.06537418
159EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04852182
160PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01772463
161ZNF263_19887448_ChIP-Seq_K562_Human1.00159151
162* NFI_21473784_ChIP-Seq_ESCs_Mouse0.96804864
163ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94086030
164CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92589820
165ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92436927
166SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90218213
167EOMES_21245162_ChIP-Seq_HESCs_Human0.90035451
168TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90014141
169SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89806004
170NCOR1_26117541_ChIP-Seq_K562_Human0.85402551
171HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84281440
172FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83591282
173GATA4_21415370_ChIP-Seq_HL-1_Mouse0.82969733
174PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.78300401
175RACK7_27058665_Chip-Seq_MCF-7_Human0.76167833
176MYB_21317192_ChIP-Seq_ERMYB_Mouse0.74556407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.44981685
2MP0002735_abnormal_chemical_nociception4.98663400
3MP0003705_abnormal_hypodermis_morpholog4.65522040
4MP0005275_abnormal_skin_tensile4.53726544
5MP0002736_abnormal_nociception_after4.44036282
6MP0001958_emphysema3.96005282
7MP0001968_abnormal_touch/_nociception3.90662624
8MP0004272_abnormal_basement_membrane3.72038592
9MP0003279_aneurysm3.64122363
10MP0005171_absent_coat_pigmentation3.42648028
11MP0001986_abnormal_taste_sensitivity3.28307724
12MP0004134_abnormal_chest_morphology3.06107376
13MP0005257_abnormal_intraocular_pressure3.01079072
14MP0003136_yellow_coat_color2.99558713
15MP0001188_hyperpigmentation2.91087646
16MP0003950_abnormal_plasma_membrane2.90613037
17MP0005394_taste/olfaction_phenotype2.87534270
18MP0005499_abnormal_olfactory_system2.87534270
19MP0004147_increased_porphyrin_level2.82679741
20MP0003566_abnormal_cell_adhesion2.78950931
21MP0003941_abnormal_skin_development2.77222343
22MP0005409_darkened_coat_color2.74500958
23MP0008789_abnormal_olfactory_epithelium2.62338479
24MP0000372_irregular_coat_pigmentation2.61084377
25MP0006054_spinal_hemorrhage2.55082903
26MP0009250_abnormal_appendicular_skeleto2.53713251
27MP0000462_abnormal_digestive_system2.29419505
28MP0005503_abnormal_tendon_morphology2.19168610
29MP0006276_abnormal_autonomic_nervous2.15932387
30MP0005023_abnormal_wound_healing2.12666173
31MP0005623_abnormal_meninges_morphology2.12589928
32MP0000566_synostosis2.11674392
33MP0000762_abnormal_tongue_morphology2.11229238
34MP0010352_gastrointestinal_tract_polyps2.05059829
35MP0002734_abnormal_mechanical_nocicepti2.03420530
36MP0001970_abnormal_pain_threshold2.01446083
37MP0001984_abnormal_olfaction1.97666375
38MP0001270_distended_abdomen1.96020296
39MP0004270_analgesia1.90787775
40MP0009379_abnormal_foot_pigmentation1.88944523
41MP0002733_abnormal_thermal_nociception1.80689415
42MP0001299_abnormal_eye_distance/1.74545702
43MP0002751_abnormal_autonomic_nervous1.74351346
44MP0010368_abnormal_lymphatic_system1.73672260
45MP0003091_abnormal_cell_migration1.72290238
46MP0000465_gastrointestinal_hemorrhage1.68086143
47MP0010030_abnormal_orbit_morphology1.66336227
48MP0002295_abnormal_pulmonary_circulatio1.66315893
49MP0009697_abnormal_copulation1.63506716
50MP0000767_abnormal_smooth_muscle1.63330611
51MP0000383_abnormal_hair_follicle1.62360227
52MP0008875_abnormal_xenobiotic_pharmacok1.55521543
53MP0001243_abnormal_dermal_layer1.53867159
54MP0001542_abnormal_bone_strength1.52306901
55MP0010678_abnormal_skin_adnexa1.51791266
56MP0002877_abnormal_melanocyte_morpholog1.47746190
57MP0000049_abnormal_middle_ear1.44288753
58MP0003937_abnormal_limbs/digits/tail_de1.37278546
59MP0000163_abnormal_cartilage_morphology1.31863264
60MP0004858_abnormal_nervous_system1.29419525
61MP0002938_white_spotting1.29392216
62MP0000678_abnormal_parathyroid_gland1.28425788
63MP0004484_altered_response_of1.25731401
64MP0001664_abnormal_digestion1.24544977
65MP0001963_abnormal_hearing_physiology1.20880318
66MP0003283_abnormal_digestive_organ1.19150316
67MP0005164_abnormal_response_to1.18716001
68MP0000013_abnormal_adipose_tissue1.17058846
69MP0002233_abnormal_nose_morphology1.15975119
70MP0003656_abnormal_erythrocyte_physiolo1.14812202
71MP0006292_abnormal_olfactory_placode1.12121016
72MP0009053_abnormal_anal_canal1.10519964
73MP0005595_abnormal_vascular_smooth1.10025111
74MP0002109_abnormal_limb_morphology1.09440397
75MP0002115_abnormal_skeleton_extremities1.08656750
76MP0000428_abnormal_craniofacial_morphol1.06514872
77MP0005083_abnormal_biliary_tract1.05829374
78MP0005381_digestive/alimentary_phenotyp1.04347952
79MP0003385_abnormal_body_wall1.03984133
80MP0000613_abnormal_salivary_gland1.03683970
81MP0009780_abnormal_chondrocyte_physiolo1.03289434
82MP0004043_abnormal_pH_regulation1.02681693
83MP0000749_muscle_degeneration1.02153636
84MP0002282_abnormal_trachea_morphology1.01404197
85MP0000534_abnormal_ureter_morphology1.01339002
86MP0000733_abnormal_muscle_development1.00451320
87MP0004264_abnormal_extraembryonic_tissu0.99947472
88MP0003755_abnormal_palate_morphology0.99553723
89MP0002272_abnormal_nervous_system0.98220682
90MP0005390_skeleton_phenotype0.97732237
91MP0001348_abnormal_lacrimal_gland0.97424709
92MP0000579_abnormal_nail_morphology0.94805791
93MP0002067_abnormal_sensory_capabilities0.92264196
94MP0002113_abnormal_skeleton_development0.90412313
95MP0005248_abnormal_Harderian_gland0.88774887
96MP0002933_joint_inflammation0.87977319
97MP0005508_abnormal_skeleton_morphology0.87447924
98MP0010386_abnormal_urinary_bladder0.86667694
99MP0000920_abnormal_myelination0.85912950
100MP0001663_abnormal_digestive_system0.85100439
101MP0005197_abnormal_uvea_morphology0.82832835
102MP0003448_altered_tumor_morphology0.82781570
103MP0001177_atelectasis0.82120885
104MP0000432_abnormal_head_morphology0.82064054
105MP0000681_abnormal_thyroid_gland0.81962054
106MP0010771_integument_phenotype0.81494773
107MP0001346_abnormal_lacrimal_gland0.80310335
108MP0000759_abnormal_skeletal_muscle0.80092213
109MP0003191_abnormal_cellular_cholesterol0.80084507
110MP0001849_ear_inflammation0.79921212
111MP0002277_abnormal_respiratory_mucosa0.79805360
112MP0000467_abnormal_esophagus_morphology0.79118621
113MP0003122_maternal_imprinting0.77126014
114MP0004883_abnormal_blood_vessel0.76991720
115MP0003787_abnormal_imprinting0.76723658
116MP0002108_abnormal_muscle_morphology0.76376827
117MP0001879_abnormal_lymphatic_vessel0.76189267
118MP0003183_abnormal_peptide_metabolism0.75131999
119MP0000026_abnormal_inner_ear0.74464978
120MP0002896_abnormal_bone_mineralization0.74240796
121MP0005165_increased_susceptibility_to0.74115227
122MP0000538_abnormal_urinary_bladder0.73903138
123MP0002128_abnormal_blood_circulation0.73515416
124MP0009745_abnormal_behavioral_response0.71634936
125MP0002932_abnormal_joint_morphology0.71555242
126MP0002160_abnormal_reproductive_system0.71201267
127MP0003795_abnormal_bone_structure0.71146194
128MP0000778_abnormal_nervous_system0.71043503
129MP0001873_stomach_inflammation0.70021443
130MP0005408_hypopigmentation0.68601591
131MP0000858_altered_metastatic_potential0.68368629
132MP0008004_abnormal_stomach_pH0.68030540
133MP0000015_abnormal_ear_pigmentation0.67859409
134MP0002133_abnormal_respiratory_system0.65972888
135MP0005388_respiratory_system_phenotype0.65972888
136MP0002168_other_aberrant_phenotype0.65957061
137MP0002177_abnormal_outer_ear0.65164860
138MP0005360_urolithiasis0.64987507
139MP0000751_myopathy0.64181001
140MP0001614_abnormal_blood_vessel0.63528492
141MP0002116_abnormal_craniofacial_bone0.62976787
142MP0002060_abnormal_skin_morphology0.62417844
143MP0001485_abnormal_pinna_reflex0.62089519
144MP0000003_abnormal_adipose_tissue0.61630777
145MP0002876_abnormal_thyroid_physiology0.60811113
146MP0009384_cardiac_valve_regurgitation0.60580252
147MP0009840_abnormal_foam_cell0.60022233
148MP0001915_intracranial_hemorrhage0.59145620
149MP0005367_renal/urinary_system_phenotyp0.58821592
150MP0000516_abnormal_urinary_system0.58821592
151MP0003935_abnormal_craniofacial_develop0.58769831
152MP0003942_abnormal_urinary_system0.58581143
153MP0002249_abnormal_larynx_morphology0.58395155
154MP0001175_abnormal_lung_morphology0.57699233
155MP0004084_abnormal_cardiac_muscle0.56499234
156MP0002998_abnormal_bone_remodeling0.55922925
157MP0005621_abnormal_cell_physiology0.55810889
158MP0004233_abnormal_muscle_weight0.54060492
159MP0005193_abnormal_anterior_eye0.52884187
160MP0003115_abnormal_respiratory_system0.52630517
161MP0002114_abnormal_axial_skeleton0.52399516
162MP0000750_abnormal_muscle_regeneration0.51077392
163MP0003045_fibrosis0.50936577
164MP0002925_abnormal_cardiovascular_devel0.50878383
165MP0003300_gastrointestinal_ulcer0.48864921

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)8.30109703
2Protrusio acetabuli (HP:0003179)7.53849911
3Aortic dissection (HP:0002647)5.60279196
4Aortic aneurysm (HP:0004942)5.48311059
5Irregular epiphyses (HP:0010582)5.14880080
6Vascular tortuosity (HP:0004948)5.10459234
7Follicular hyperkeratosis (HP:0007502)4.79247677
8Arterial tortuosity (HP:0005116)4.67578825
9Soft skin (HP:0000977)4.61053001
10Ankle contracture (HP:0006466)4.60425970
11Abnormal tarsal ossification (HP:0008369)4.50841206
12Cupped ribs (HP:0000887)4.48089543
13Bladder diverticulum (HP:0000015)4.31798023
14Flat capital femoral epiphysis (HP:0003370)4.13636674
15Abnormality of dentin (HP:0010299)3.94494521
16Asymmetry of the thorax (HP:0001555)3.92945808
17Epiphyseal dysplasia (HP:0002656)3.92531618
18Wormian bones (HP:0002645)3.83538374
19Spinal rigidity (HP:0003306)3.81500081
20Spondylolisthesis (HP:0003302)3.77281540
21Cervical subluxation (HP:0003308)3.66057239
22Flat acetabular roof (HP:0003180)3.60766184
23Dilatation of the ascending aorta (HP:0005111)3.56508415
24Slender build (HP:0001533)3.56207196
25Genu recurvatum (HP:0002816)3.38556084
26Nemaline bodies (HP:0003798)3.33667685
27Degeneration of the lateral corticospinal tracts (HP:0002314)3.30281114
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.30281114
29Limited hip movement (HP:0008800)3.23563824
30Neonatal short-limb short stature (HP:0008921)3.15472017
31Abnormal foot bone ossification (HP:0010675)3.13873131
32Blue sclerae (HP:0000592)3.12312657
33Broad metatarsal (HP:0001783)3.11123770
34Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.05171299
35Abnormality of femoral epiphyses (HP:0006499)3.05171299
36Peritonitis (HP:0002586)3.04847663
37Abnormality of the epiphysis of the femoral head (HP:0010574)3.04117191
38Osteolytic defects of the hand bones (HP:0009699)3.04068037
39Osteolytic defects of the phalanges of the hand (HP:0009771)3.04068037
40Abnormality of the phalanges of the 2nd finger (HP:0009541)3.01020740
41Overgrowth (HP:0001548)2.98088290
42Small epiphyses (HP:0010585)2.96307565
43Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.95429946
44Abnormality of carpal bone ossification (HP:0006257)2.94165200
45Abnormality of the femoral head (HP:0003368)2.94096495
46Abnormality of the acetabulum (HP:0003170)2.93484411
47Genu varum (HP:0002970)2.92470627
48Mildly elevated creatine phosphokinase (HP:0008180)2.91145779
49Joint laxity (HP:0001388)2.89999689
50Aortic regurgitation (HP:0001659)2.87866557
51Bowel diverticulosis (HP:0005222)2.87854709
52Mitral valve prolapse (HP:0001634)2.87026238
53Vertebral compression fractures (HP:0002953)2.85525363
54Shallow orbits (HP:0000586)2.84646708
55Muscle fiber inclusion bodies (HP:0100299)2.81776866
56Elbow flexion contracture (HP:0002987)2.78976434
57Delayed epiphyseal ossification (HP:0002663)2.77774689
58Hypoplastic ischia (HP:0003175)2.77152229
59Abnormality of the ischium (HP:0003174)2.76422484
60Abnormality of the corticospinal tract (HP:0002492)2.76183597
61Abnormality of the 2nd finger (HP:0004100)2.74055464
62Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.73731682
63Abnormality of the pubic bones (HP:0003172)2.73101587
64Abnormal delivery (HP:0001787)2.68219282
65Hyperextensible skin (HP:0000974)2.67973980
66Metaphyseal irregularity (HP:0003025)2.67536210
67Abnormality of the middle phalanges of the toes (HP:0010183)2.63833351
68Nonimmune hydrops fetalis (HP:0001790)2.63469974
69Short femoral neck (HP:0100864)2.62000889
70Hip contracture (HP:0003273)2.60896823
71Onycholysis (HP:0001806)2.59125296
72Cardiovascular calcification (HP:0011915)2.59002177
73Lip pit (HP:0100267)2.58532730
74Barrel-shaped chest (HP:0001552)2.56959750
75Vitreoretinal degeneration (HP:0000655)2.56687859
76Chromosomal breakage induced by crosslinking agents (HP:0003221)2.56341132
77Mild short stature (HP:0003502)2.51932898
78Absent phalangeal crease (HP:0006109)2.51001811
79Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.50230035
80Abnormality of incisor morphology (HP:0011063)2.49851452
81Breech presentation (HP:0001623)2.49489301
82Nephroblastoma (Wilms tumor) (HP:0002667)2.48812482
83Aneurysm (HP:0002617)2.47431522
84Morphological abnormality of the middle ear (HP:0008609)2.46939473
85Embryonal renal neoplasm (HP:0011794)2.44857833
86White forelock (HP:0002211)2.42976980
87Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.41657320
88Redundant skin (HP:0001582)2.41609948
89Mitral regurgitation (HP:0001653)2.40943047
90Disproportionate tall stature (HP:0001519)2.40287491
91Increased variability in muscle fiber diameter (HP:0003557)2.38906629
92Increased connective tissue (HP:0009025)2.35949759
93Irregular vertebral endplates (HP:0003301)2.33729046
94Fibular aplasia (HP:0002990)2.32832824
95Patchy hypopigmentation of hair (HP:0011365)2.30741565
96Abnormality of the vertebral endplates (HP:0005106)2.29968136
97Metaphyseal cupping (HP:0003021)2.28231492
98Hypoventilation (HP:0002791)2.26413362
99Metaphyseal dysplasia (HP:0100255)2.23726093
100Type 1 muscle fiber predominance (HP:0003803)2.22491370
101Distal arthrogryposis (HP:0005684)2.22154935
102Mesomelia (HP:0003027)2.20686797
103Distal upper limb amyotrophy (HP:0007149)2.20247380
104Upper limb amyotrophy (HP:0009129)2.20247380
105Abnormal hair whorl (HP:0010721)2.18133356
106Wide anterior fontanel (HP:0000260)2.17962954
107Abnormal finger flexion creases (HP:0006143)2.17634187
108Hypothermia (HP:0002045)2.16176113
109Fibular hypoplasia (HP:0003038)2.16123597
110Aplasia of the musculature (HP:0100854)2.13992551
111Stridor (HP:0010307)2.13054887
112Abnormality of the nasolacrimal system (HP:0000614)2.11838493
113Cerebral aneurysm (HP:0004944)2.11682980
114Delayed closure of the anterior fontanelle (HP:0001476)2.10941515
115Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.10668009
116Joint stiffness (HP:0001387)2.10169591
117Aortic valve stenosis (HP:0001650)2.09737982
118Flat cornea (HP:0007720)2.09476821
119Abnormality of the lacrimal duct (HP:0011481)2.08670402
120Abnormality of the proximal phalanges of the hand (HP:0009834)2.08189677
121Cutaneous finger syndactyly (HP:0010554)2.07910234
122Short nail (HP:0001799)2.06699451
123Hypomagnesemia (HP:0002917)2.06463113
124Ulnar claw (HP:0001178)2.06182496
125Coronal craniosynostosis (HP:0004440)2.05269806
126Arthropathy (HP:0003040)2.05113166
127Ectopia lentis (HP:0001083)2.04458472
128Aplastic anemia (HP:0001915)2.03742122
129Entropion (HP:0000621)2.03706401
130Broad ribs (HP:0000885)2.02750453
131Chromsome breakage (HP:0040012)2.00367279
132Abnormality of skeletal muscle fiber size (HP:0012084)2.00195936
133Popliteal pterygium (HP:0009756)1.99720259
134Sleep apnea (HP:0010535)1.99338651
135Fragile skin (HP:0001030)1.98329551
136Osteoarthritis (HP:0002758)1.97214939
137Abnormal vertebral ossification (HP:0100569)1.96044976
138Tracheomalacia (HP:0002779)1.95328130
139Stillbirth (HP:0003826)1.92838884
140Disproportionate short-trunk short stature (HP:0003521)1.91906873
141Abnormality of the lumbar spine (HP:0100712)1.91677581
142Natal tooth (HP:0000695)1.91646729
143Femoral bowing (HP:0002980)1.90546046
144Ovoid vertebral bodies (HP:0003300)1.90031901
145Abnormal lung lobation (HP:0002101)1.89611174
146Protruding ear (HP:0000411)1.89186577
147Round ear (HP:0100830)1.88290705
148Abnormal hand bone ossification (HP:0010660)1.88196307
149Submucous cleft hard palate (HP:0000176)1.86568421
150Dysautonomia (HP:0002459)1.86132358
151Thoracolumbar scoliosis (HP:0002944)1.85587694
152Generalized amyotrophy (HP:0003700)1.85542889
153Hand muscle atrophy (HP:0009130)1.85350333
154Cutaneous syndactyly (HP:0012725)1.85056064
155Spinal cord lesions (HP:0100561)1.84468036
156Syringomyelia (HP:0003396)1.84468036
157Ulnar bowing (HP:0003031)1.84382602
158Reduced subcutaneous adipose tissue (HP:0003758)1.84108774
159Biconcave vertebral bodies (HP:0004586)1.83965293
160Mitral stenosis (HP:0001718)1.83624526
161Ileus (HP:0002595)1.83363932
162Inguinal hernia (HP:0000023)1.83195023
163Spinal cord compression (HP:0002176)1.82772780
164Coxa vara (HP:0002812)1.82087277
165Abnormal ossification of hand bones (HP:0005921)1.82014578
166Flattened epiphyses (HP:0003071)1.81722716
167Symphalangism affecting the phalanges of the hand (HP:0009773)1.81644433
168Abnormality of the phalanges of the 5th finger (HP:0004213)1.80866533
169Ankyloglossia (HP:0010296)1.80758971
170Absent frontal sinuses (HP:0002688)1.79606098
171Abnormality of skull ossification (HP:0002703)1.79158160
172Delayed cranial suture closure (HP:0000270)1.79112234
173Short middle phalanx of finger (HP:0005819)1.79015752
174Thin skin (HP:0000963)1.78936518
175Camptodactyly of toe (HP:0001836)1.78359598
176Nonprogressive disorder (HP:0003680)1.78186837
177Abnormality of magnesium homeostasis (HP:0004921)1.78100920
178Abnormality of the fibula (HP:0002991)1.77493472
179Polycythemia (HP:0001901)1.77416705
180Platyspondyly (HP:0000926)1.77091453
181Wrist flexion contracture (HP:0001239)1.75970093
182Beaking of vertebral bodies (HP:0004568)1.75850308
183Venous abnormality (HP:0002624)1.75709418
184Limb-girdle muscle weakness (HP:0003325)1.75388203
185Atrophic scars (HP:0001075)1.75224309
186Hallux valgus (HP:0001822)1.73820060
187Deviation of the hallux (HP:0010051)1.73785311
188Flared iliac wings (HP:0002869)1.73652855
189Tibial bowing (HP:0002982)1.71017869
190Premature skin wrinkling (HP:0100678)1.70268965
191Decreased skull ossification (HP:0004331)1.69028753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.62770661
2PDGFRA3.69520857
3MST1R3.64810896
4NEK93.05867105
5MET2.70683344
6LMTK22.63990071
7PTK22.57966103
8TNIK2.57747589
9PAK22.56920886
10ADRBK22.43649884
11FRK2.42765710
12EPHA22.24340999
13OXSR12.13126343
14TTN2.08355026
15SGK22.07538030
16STK392.07504195
17AKT32.00140211
18TESK11.99957395
19TRPM71.99398818
20TGFBR21.98264863
21EPHB11.91297181
22LIMK11.84202046
23SGK4941.82677747
24SGK2231.82677747
25PIK3CG1.82270131
26PRKG21.78504955
27CASK1.77990050
28MAP2K61.76169683
29ERN11.68076511
30GRK71.67057333
31PAK41.65521298
32INSRR1.64978736
33SGK31.62010547
34NUAK11.61872145
35LATS21.61579455
36NTRK11.61216142
37RIPK11.58027627
38MATK1.55555841
39SCYL21.54865331
40STK381.53998380
41EIF2AK11.50831383
42BMPR1B1.49818422
43MKNK11.45991164
44CDK191.41975077
45YES11.41878647
46FLT31.40737051
47ERBB31.36322237
48MAPKAPK51.29887874
49PRKD21.29376348
50RIPK41.26869986
51OBSCN1.23835060
52MAP2K71.22179419
53PDGFRB1.21210650
54NME11.20882905
55CSNK1A1L1.19455605
56MAPK131.19168012
57DDR21.18807747
58ZAK1.16449738
59NEK61.15459666
60NLK1.15432685
61SIK11.15370777
62PIK3CA1.14698495
63CLK11.13696284
64ERBB41.10819414
65TEC1.10777227
66MAP3K61.07677689
67STK31.06156181
68KSR21.04952048
69MAP2K21.04386543
70MOS1.03162352
71ROCK11.02201372
72PIM20.99895729
73BRSK20.98795805
74ICK0.98750977
75CCNB10.98161132
76MKNK20.95506886
77MAP3K120.93683621
78MINK10.92867679
79BMX0.91034959
80CDC42BPA0.89350365
81ILK0.88154297
82MAP3K20.85873006
83CSNK1G30.85776722
84PINK10.84270571
85FER0.83711968
86NTRK30.83186887
87WNK10.83159477
88MARK30.82430489
89EPHA30.82281814
90ABL20.81876787
91PRKCE0.80887880
92EPHB20.79756939
93MAP2K10.79373649
94TRIB30.78842265
95TAOK20.78768714
96RAF10.77793508
97MAP3K30.77239384
98BMPR20.75932368
99PLK20.75868286
100PBK0.75786221
101PTK2B0.73466457
102CDK80.72003095
103MTOR0.71996953
104IRAK30.71832264
105EIF2AK20.71209297
106LATS10.71166451
107CSNK1G20.70940694
108CSNK1G10.68124513
109MAPKAPK30.66979151
110MAP2K30.66235160
111MAP3K80.65764843
112ARAF0.62589914
113EEF2K0.61136043
114PKN10.60435800
115PAK10.60290835
116KSR10.58567834
117CAMK2D0.58133081
118MAPK70.58094655
119JAK10.57212166
120MELK0.56492837
121SIK30.56101937
122ADRBK10.55915910
123STK160.55518491
124GRK50.54764477
125FGFR20.53916873
126MYLK0.53801861
127NEK10.53383411
128GSK3A0.51900419
129CDK30.51456668
130DAPK30.51448327
131TTK0.50806709
132PHKG20.49898829
133PHKG10.49898829
134DMPK0.48943476
135CDK120.48774012
136STK100.46383941
137MAP3K70.45377726
138TXK0.45245768
139CAMK40.43836066
140ROCK20.43206380
141STK38L0.43072865
142PKN20.42395925
143BRAF0.39835303
144CAMK2A0.39426493
145CAMK2G0.39154099
146RPS6KB10.37095341
147TSSK60.36654910
148PRKG10.36590135
149ERBB20.36122392
150PDPK10.35865543
151PTK60.35488857
152SGK10.34737104
153RPS6KA20.34408704
154CAMK2B0.34385306
155MAPKAPK20.34333419
156TIE10.33938711
157PLK30.33932684
158JAK30.33668606
159MAPK120.32574007
160MAP3K140.32263279
161NEK20.31662496
162BRSK10.29750717
163WNK40.29352818
164KIT0.27342764
165TYK20.27321804
166PAK30.26996425
167TGFBR10.24540740
168PAK60.24514969

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.69890018
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.26425870
3AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.33126073
4Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.31077301
5Proteoglycans in cancer_Homo sapiens_hsa052052.30854827
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.30407566
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.27725087
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.24411730
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.06636090
10Mineral absorption_Homo sapiens_hsa049782.05495866
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.03189215
12Amoebiasis_Homo sapiens_hsa051462.01233741
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92276845
14Regulation of actin cytoskeleton_Homo sapiens_hsa048101.86948283
15Steroid biosynthesis_Homo sapiens_hsa001001.86834659
16Small cell lung cancer_Homo sapiens_hsa052221.83230432
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.79122107
18Bladder cancer_Homo sapiens_hsa052191.78893498
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.78308767
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.77706023
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.76461078
22* Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.73523927
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70876189
24Starch and sucrose metabolism_Homo sapiens_hsa005001.70515872
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.69176846
26Protein digestion and absorption_Homo sapiens_hsa049741.66878108
27TGF-beta signaling pathway_Homo sapiens_hsa043501.64915096
28ECM-receptor interaction_Homo sapiens_hsa045121.64198241
29Thyroid cancer_Homo sapiens_hsa052161.62063002
30Chronic myeloid leukemia_Homo sapiens_hsa052201.60634277
31Vitamin digestion and absorption_Homo sapiens_hsa049771.59333932
32MicroRNAs in cancer_Homo sapiens_hsa052061.51837809
33Olfactory transduction_Homo sapiens_hsa047401.49621030
34Other glycan degradation_Homo sapiens_hsa005111.45721308
35Dilated cardiomyopathy_Homo sapiens_hsa054141.44779344
36Arachidonic acid metabolism_Homo sapiens_hsa005901.43715978
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35394948
38Chemical carcinogenesis_Homo sapiens_hsa052041.34100795
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33760168
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.31268528
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30051060
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29784618
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.28691511
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.27631327
45Retinol metabolism_Homo sapiens_hsa008301.24360390
46Tight junction_Homo sapiens_hsa045301.23245684
47p53 signaling pathway_Homo sapiens_hsa041151.22947320
48Fatty acid elongation_Homo sapiens_hsa000621.22575087
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20584296
50Axon guidance_Homo sapiens_hsa043601.20394654
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16771090
52Pancreatic cancer_Homo sapiens_hsa052121.14245615
53Vibrio cholerae infection_Homo sapiens_hsa051101.13010343
54Pathways in cancer_Homo sapiens_hsa052001.12372903
55Malaria_Homo sapiens_hsa051441.11405515
56Shigellosis_Homo sapiens_hsa051311.10394707
57Renin-angiotensin system_Homo sapiens_hsa046141.07757866
58Glutathione metabolism_Homo sapiens_hsa004801.07068039
59Leukocyte transendothelial migration_Homo sapiens_hsa046701.03335491
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02963794
61Sulfur relay system_Homo sapiens_hsa041221.01355624
62Melanoma_Homo sapiens_hsa052180.98840458
63Glioma_Homo sapiens_hsa052140.95687689
64Salmonella infection_Homo sapiens_hsa051320.95547972
65Renal cell carcinoma_Homo sapiens_hsa052110.95419806
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.95187820
67Taste transduction_Homo sapiens_hsa047420.94671850
68Histidine metabolism_Homo sapiens_hsa003400.94426562
69Melanogenesis_Homo sapiens_hsa049160.94061571
70Endometrial cancer_Homo sapiens_hsa052130.93490290
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92905958
72Ether lipid metabolism_Homo sapiens_hsa005650.91024855
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90481011
74Gap junction_Homo sapiens_hsa045400.81746081
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81332291
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80027839
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78632654
78Endocytosis_Homo sapiens_hsa041440.77050786
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75463202
80Basal cell carcinoma_Homo sapiens_hsa052170.74916451
81Serotonergic synapse_Homo sapiens_hsa047260.73502634
82Salivary secretion_Homo sapiens_hsa049700.72799441
83ErbB signaling pathway_Homo sapiens_hsa040120.72716135
84Prion diseases_Homo sapiens_hsa050200.71428110
85Gastric acid secretion_Homo sapiens_hsa049710.71292340
86Sphingolipid metabolism_Homo sapiens_hsa006000.69853665
87Galactose metabolism_Homo sapiens_hsa000520.69368686
88Autoimmune thyroid disease_Homo sapiens_hsa053200.69329133
89Hedgehog signaling pathway_Homo sapiens_hsa043400.68775139
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67810561
91Vitamin B6 metabolism_Homo sapiens_hsa007500.67186014
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66407295
93Wnt signaling pathway_Homo sapiens_hsa043100.66278232
94Hepatitis C_Homo sapiens_hsa051600.66037919
95Prostate cancer_Homo sapiens_hsa052150.65858856
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64533811
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64294381
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63665780
99Lysosome_Homo sapiens_hsa041420.62452946
100Circadian entrainment_Homo sapiens_hsa047130.61162478
101Complement and coagulation cascades_Homo sapiens_hsa046100.60889466
102Thyroid hormone synthesis_Homo sapiens_hsa049180.60293685
103mTOR signaling pathway_Homo sapiens_hsa041500.58795896
104Long-term depression_Homo sapiens_hsa047300.58760791
105Pentose phosphate pathway_Homo sapiens_hsa000300.57846658
106Hepatitis B_Homo sapiens_hsa051610.57822960
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55889178
108N-Glycan biosynthesis_Homo sapiens_hsa005100.55588226
109Focal adhesion_Homo sapiens_hsa045100.55248064
110Folate biosynthesis_Homo sapiens_hsa007900.54953216
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54627929
112Fructose and mannose metabolism_Homo sapiens_hsa000510.54043305
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.52531304
114Butanoate metabolism_Homo sapiens_hsa006500.51654656
115TNF signaling pathway_Homo sapiens_hsa046680.51277108
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.50330967
117Phagosome_Homo sapiens_hsa041450.49865506
118Platelet activation_Homo sapiens_hsa046110.45615824
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45568485
120Apoptosis_Homo sapiens_hsa042100.44836274
121Calcium signaling pathway_Homo sapiens_hsa040200.44623434
122Hematopoietic cell lineage_Homo sapiens_hsa046400.44622420
123Acute myeloid leukemia_Homo sapiens_hsa052210.44389170
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43634213
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42550892
126Non-small cell lung cancer_Homo sapiens_hsa052230.42279069
127Collecting duct acid secretion_Homo sapiens_hsa049660.40950626
128Nicotine addiction_Homo sapiens_hsa050330.40312967
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38931026
130Non-homologous end-joining_Homo sapiens_hsa034500.38835224
131One carbon pool by folate_Homo sapiens_hsa006700.38676445
132Prolactin signaling pathway_Homo sapiens_hsa049170.38631858
133Glutamatergic synapse_Homo sapiens_hsa047240.38616633
134Nucleotide excision repair_Homo sapiens_hsa034200.38100318
135Rap1 signaling pathway_Homo sapiens_hsa040150.37452136
136Toxoplasmosis_Homo sapiens_hsa051450.37413577
137Cholinergic synapse_Homo sapiens_hsa047250.36472791
138Hippo signaling pathway_Homo sapiens_hsa043900.35954091
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35652513
140ABC transporters_Homo sapiens_hsa020100.35595744
141Adherens junction_Homo sapiens_hsa045200.34312462
142Oxidative phosphorylation_Homo sapiens_hsa001900.33964161
143Rheumatoid arthritis_Homo sapiens_hsa053230.33901438
144Morphine addiction_Homo sapiens_hsa050320.33629061
145Ras signaling pathway_Homo sapiens_hsa040140.33269570
146cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32211963
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.32199601
148Pertussis_Homo sapiens_hsa051330.32193452
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31874194
150HTLV-I infection_Homo sapiens_hsa051660.30999801
151HIF-1 signaling pathway_Homo sapiens_hsa040660.30689333
152Alzheimers disease_Homo sapiens_hsa050100.30494142
153MAPK signaling pathway_Homo sapiens_hsa040100.29298018
154Neurotrophin signaling pathway_Homo sapiens_hsa047220.28907459
155Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27319686

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