GALNT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.33079215
2axon ensheathment in central nervous system (GO:0032291)6.33079215
3positive regulation of gamma-delta T cell activation (GO:0046645)5.33227267
4positive regulation of keratinocyte differentiation (GO:0045618)4.89795841
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.69963335
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.69963335
7regulation of gamma-delta T cell differentiation (GO:0045586)4.44577614
8positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.39785718
9negative T cell selection (GO:0043383)4.34243044
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.29702462
11negative thymic T cell selection (GO:0045060)4.28561153
12leukocyte aggregation (GO:0070486)4.27230012
13desmosome organization (GO:0002934)4.26907822
14mast cell activation (GO:0045576)4.14646437
15regulation of water loss via skin (GO:0033561)4.11019327
16diol metabolic process (GO:0034311)4.10251694
17regulation of gamma-delta T cell activation (GO:0046643)4.06533107
18COPI coating of Golgi vesicle (GO:0048205)4.06052297
19Golgi transport vesicle coating (GO:0048200)4.06052297
20iron ion import (GO:0097286)4.01973375
21antigen processing and presentation of endogenous antigen (GO:0019883)3.93160810
22hepatocyte apoptotic process (GO:0097284)3.85392228
23ensheathment of neurons (GO:0007272)3.82320939
24axon ensheathment (GO:0008366)3.82320939
25skin morphogenesis (GO:0043589)3.80403195
26hemidesmosome assembly (GO:0031581)3.78693267
27regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.77493453
28positive regulation of epidermal cell differentiation (GO:0045606)3.76459431
29intestinal epithelial cell development (GO:0060576)3.71043248
30myelination (GO:0042552)3.69838792
31sphingosine metabolic process (GO:0006670)3.69650574
32T cell migration (GO:0072678)3.68263956
33positive thymic T cell selection (GO:0045059)3.61314871
34dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.59627590
35creatine metabolic process (GO:0006600)3.57647782
36interferon-gamma production (GO:0032609)3.57317026
37sphingoid metabolic process (GO:0046519)3.55455869
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.54942221
39negative regulation of cell killing (GO:0031342)3.54942221
40positive regulation of Cdc42 GTPase activity (GO:0043089)3.53297370
41thymic T cell selection (GO:0045061)3.46816808
42tolerance induction (GO:0002507)3.46597485
43glycosphingolipid catabolic process (GO:0046479)3.45066542
44regulation of isotype switching to IgG isotypes (GO:0048302)3.44141491
45regulation of interleukin-2 biosynthetic process (GO:0045076)3.42754729
46neutrophil activation involved in immune response (GO:0002283)3.42351097
47positive regulation of interleukin-2 production (GO:0032743)3.42335931
48myelin maintenance (GO:0043217)3.42124271
49amyloid precursor protein metabolic process (GO:0042982)3.39755487
50maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.39039521
51mast cell degranulation (GO:0043303)3.38810238
52mast cell activation involved in immune response (GO:0002279)3.38810238
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.38744963
54regulation of T cell receptor signaling pathway (GO:0050856)3.38128035
55fatty acid elongation (GO:0030497)3.35815468
56GDP-mannose metabolic process (GO:0019673)3.32868197
57establishment of skin barrier (GO:0061436)3.26603877
58T cell receptor signaling pathway (GO:0050852)3.24175083
59T cell selection (GO:0045058)3.23877647
60regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.21844009
61regulation of keratinocyte differentiation (GO:0045616)3.21806207
62activated T cell proliferation (GO:0050798)3.19713174
63virion attachment to host cell (GO:0019062)3.19379761
64adhesion of symbiont to host cell (GO:0044650)3.19379761
65cellular copper ion homeostasis (GO:0006878)3.18948123
66pyrimidine-containing compound transmembrane transport (GO:0072531)3.18202660
67positive regulation of epidermis development (GO:0045684)3.17200171
68amyloid precursor protein catabolic process (GO:0042987)3.16732868
69decidualization (GO:0046697)3.16390685
70response to interleukin-15 (GO:0070672)3.15889473
71oligosaccharide catabolic process (GO:0009313)3.13303299
72regulation of B cell receptor signaling pathway (GO:0050855)3.12624988
73sphingomyelin metabolic process (GO:0006684)3.10128103
74branching involved in mammary gland duct morphogenesis (GO:0060444)3.07463080
75T cell costimulation (GO:0031295)3.07133111
76glycolipid catabolic process (GO:0019377)3.07013667
77proline biosynthetic process (GO:0006561)3.06349572
78multicellular organismal water homeostasis (GO:0050891)3.06345824
79protein retention in ER lumen (GO:0006621)3.04217480
80positive T cell selection (GO:0043368)3.04056334
81lymphocyte costimulation (GO:0031294)3.03027521
82positive regulation of B cell differentiation (GO:0045579)3.00592594
83antigen receptor-mediated signaling pathway (GO:0050851)2.99623020
84regulation of T cell tolerance induction (GO:0002664)2.99031891
85regulation of alpha-beta T cell proliferation (GO:0046640)2.96704669
86leukocyte cell-cell adhesion (GO:0007159)2.95209181
87positive regulation of interleukin-4 production (GO:0032753)2.93510174
88response to lipoprotein particle (GO:0055094)2.93205873
89regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.93084148
90ceramide catabolic process (GO:0046514)2.92781426
91interferon-gamma secretion (GO:0072643)2.92245169
92leukocyte degranulation (GO:0043299)2.91006614
93membrane raft organization (GO:0031579)2.90883693
94sphingolipid catabolic process (GO:0030149)2.90089689
95B cell receptor signaling pathway (GO:0050853)2.89265637
96negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.88998821
97membrane lipid catabolic process (GO:0046466)2.87438497
98positive regulation of tolerance induction (GO:0002645)2.86896490
99ear development (GO:0043583)2.86548071
100NIK/NF-kappaB signaling (GO:0038061)2.86525410
101cellular response to interleukin-15 (GO:0071350)2.84198126
102myeloid cell activation involved in immune response (GO:0002275)2.82992826
103positive regulation of alpha-beta T cell proliferation (GO:0046641)2.82833681
104respiratory burst (GO:0045730)2.81384704
105axonemal dynein complex assembly (GO:0070286)2.79319869
106negative regulation of T cell differentiation in thymus (GO:0033085)2.78147540
107positive regulation of interleukin-17 production (GO:0032740)2.76933094
108regulation of vitamin D biosynthetic process (GO:0060556)2.76701010
109glycosylceramide metabolic process (GO:0006677)2.76374698
110regulation of regulatory T cell differentiation (GO:0045589)2.75926893
111negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.74275825
112protein localization to endosome (GO:0036010)2.73190780
113bundle of His cell to Purkinje myocyte communication (GO:0086069)2.72985678
114regulation of cell proliferation involved in kidney development (GO:1901722)2.72977846
115negative regulation of T cell receptor signaling pathway (GO:0050860)2.70452522
116apoptotic cell clearance (GO:0043277)2.70317398
117positive regulation of T cell cytokine production (GO:0002726)2.70177042
118cell adhesion mediated by integrin (GO:0033627)2.69969940
119positive regulation of T cell differentiation in thymus (GO:0033089)2.68831622
120amino sugar catabolic process (GO:0046348)2.68619834
121regulation of B cell differentiation (GO:0045577)2.68351951
122T cell homeostasis (GO:0043029)2.67995708
123mannose metabolic process (GO:0006013)2.67622407
124positive regulation of tissue remodeling (GO:0034105)2.67527345
125motile cilium assembly (GO:0044458)2.65835430
126positive regulation of antigen processing and presentation (GO:0002579)2.64118296
127regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.62829662
128heterotypic cell-cell adhesion (GO:0034113)2.62434483
129positive regulation by symbiont of host defense response (GO:0052509)2.62175239
130modulation by symbiont of host defense response (GO:0052031)2.62175239
131modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.62175239
132modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.62175239
133positive regulation by organism of defense response of other organism involved in symbiotic interact2.62175239
134modulation by symbiont of host immune response (GO:0052553)2.62175239
135negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.61757988
136keratinocyte development (GO:0003334)2.61098847
137regulation of interleukin-2 production (GO:0032663)2.60664807
138immunoglobulin mediated immune response (GO:0016064)2.60149510
139positive regulation of isotype switching (GO:0045830)2.56556637
140mammary gland epithelial cell proliferation (GO:0033598)2.55823980
141angiogenesis involved in wound healing (GO:0060055)2.55815869
142pinocytosis (GO:0006907)2.55679320
143primary alcohol catabolic process (GO:0034310)2.54939411
144regulation of apoptotic process involved in morphogenesis (GO:1902337)2.54719607
145endothelial cell chemotaxis (GO:0035767)2.54377685
146positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.54040686
147Arp2/3 complex-mediated actin nucleation (GO:0034314)2.53267827
148endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.53024607
149vagina development (GO:0060068)2.51990302
150response to peptidoglycan (GO:0032494)2.51519991
151regulation of tolerance induction (GO:0002643)2.51250892
152positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.51172397
153membrane protein ectodomain proteolysis (GO:0006509)2.51133739
154water homeostasis (GO:0030104)2.51017391
155ER overload response (GO:0006983)2.48455691
156neutrophil activation (GO:0042119)2.48186256
157regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.47181769
158negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.47007233
159vitamin transmembrane transport (GO:0035461)2.46463637
160* O-glycan processing (GO:0016266)2.46092899
161response to protozoan (GO:0001562)2.45925120
162long-chain fatty acid biosynthetic process (GO:0042759)2.45063536
163membrane protein intracellular domain proteolysis (GO:0031293)2.44486262
164negative regulation of erythrocyte differentiation (GO:0045647)2.43501075
165myeloid dendritic cell activation (GO:0001773)2.42756516
166copper ion homeostasis (GO:0055070)2.42653934
167norepinephrine metabolic process (GO:0042415)2.42353532
168semaphorin-plexin signaling pathway (GO:0071526)2.42345672
169calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.42070063
170glutathione biosynthetic process (GO:0006750)2.42012588
171cytokine biosynthetic process (GO:0042089)2.41242806
172regulation of vitamin metabolic process (GO:0030656)2.40180690
173defense response to protozoan (GO:0042832)2.40062848
174positive regulation of monocyte chemotaxis (GO:0090026)2.39140869
175epithelial cell-cell adhesion (GO:0090136)2.38952843
176tRNA methylation (GO:0030488)2.37905532
177tight junction assembly (GO:0070830)2.36462743
178cell differentiation involved in embryonic placenta development (GO:0060706)2.28379375
179barbed-end actin filament capping (GO:0051016)2.27883242
180cellular response to exogenous dsRNA (GO:0071360)2.27644288
181muscle cell migration (GO:0014812)2.25408739
182response to vitamin D (GO:0033280)2.24947664
183chaperone mediated protein folding requiring cofactor (GO:0051085)2.24869899
184response to water (GO:0009415)2.24436310
185glucose catabolic process (GO:0006007)2.21996417
186UDP-N-acetylglucosamine metabolic process (GO:0006047)2.21623477
187negative regulation of protein tyrosine kinase activity (GO:0061099)2.20107348
188positive regulation of bone resorption (GO:0045780)2.19880195
189positive regulation of bone remodeling (GO:0046852)2.19880195
190epithelial cell differentiation involved in prostate gland development (GO:0060742)2.19718801
191autophagic vacuole fusion (GO:0000046)2.19660023
192N-acetylneuraminate metabolic process (GO:0006054)2.19211086
193regulation of Cdc42 GTPase activity (GO:0043088)2.16797064
194regulation of viral release from host cell (GO:1902186)2.16411189

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.19167670
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.66880733
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.78559359
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.71114110
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.57122428
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.56727136
7ESR1_20079471_ChIP-ChIP_T-47D_Human3.52915032
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.45230047
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.43535643
10ESR2_21235772_ChIP-Seq_MCF-7_Human3.37061128
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.97331285
12ZNF263_19887448_ChIP-Seq_K562_Human2.96649276
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83655795
14SCL_19346495_ChIP-Seq_HPC-7_Human2.80924408
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.80364568
16* RUNX_20019798_ChIP-Seq_JUKART_Human2.73583960
17* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.73167764
18VDR_21846776_ChIP-Seq_THP-1_Human2.71434234
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.63748994
20* IRF8_27001747_Chip-Seq_BMDM_Mouse2.61890284
21* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.61286734
22* MYB_26560356_Chip-Seq_TH2_Human2.60796931
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.60523840
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.55340761
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54380660
26* RACK7_27058665_Chip-Seq_MCF-7_Human2.39661088
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.35615720
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.34049750
29MAF_26560356_Chip-Seq_TH1_Human2.30730599
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.30648193
31* RUNX1_22412390_ChIP-Seq_EML_Mouse2.30063878
32MYC_22102868_ChIP-Seq_BL_Human2.28736736
33SPI1_23547873_ChIP-Seq_NB4_Human2.22387334
34E2F7_22180533_ChIP-Seq_HELA_Human2.21060552
35VDR_24763502_ChIP-Seq_THP-1_Human2.18741962
36UTX_26944678_Chip-Seq_JUKART_Human2.16773119
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15292697
38MYB_26560356_Chip-Seq_TH1_Human2.15178415
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10905450
40* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.07014613
41RUNX1_27514584_Chip-Seq_MCF-7_Human2.00085426
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97472274
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94656746
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94240690
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88476357
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88389473
47* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.79029574
48* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78175231
49* SPI1_23127762_ChIP-Seq_K562_Human1.75583586
50* MAF_26560356_Chip-Seq_TH2_Human1.75262644
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74878742
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74689449
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72226680
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71428171
55ELF5_23300383_ChIP-Seq_T47D_Human1.65377168
56* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64999883
57SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.62056549
58SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.62056549
59* GATA3_27048872_Chip-Seq_THYMUS_Human1.61892846
60P63_26484246_Chip-Seq_KERATINOCYTES_Human1.61346046
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61185712
62LXR_22292898_ChIP-Seq_THP-1_Human1.60573817
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57840914
64* TCF7_22412390_ChIP-Seq_EML_Mouse1.57229511
65* GATA3_24758297_ChIP-Seq_MCF-7_Human1.56894046
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55555774
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53687645
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51096293
69GATA6_25053715_ChIP-Seq_YYC3_Human1.50985148
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50199588
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.49043493
72ATF3_27146783_Chip-Seq_COLON_Human1.47066951
73* KDM2B_26808549_Chip-Seq_DND41_Human1.46477249
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.45819181
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45715637
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43541011
77* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43284631
78PU_27001747_Chip-Seq_BMDM_Mouse1.39289036
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38011139
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36817538
81* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34519104
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34390269
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33860051
84* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33099445
85* SOX2_20726797_ChIP-Seq_SW620_Human1.32881247
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31455685
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30835472
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28693262
89* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28471939
90AHR_22903824_ChIP-Seq_MCF-7_Human1.27868843
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24807490
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23821123
93* ELK3_25401928_ChIP-Seq_HUVEC_Human1.22667943
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22610366
95GATA3_26560356_Chip-Seq_TH2_Human1.22454820
96GATA1_19941826_ChIP-Seq_K562_Human1.21801875
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20469522
98* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19501104
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18982369
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18698006
101JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18530893
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17366281
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16523304
104* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15590931
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15203509
106STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14818395
107* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13906653
108PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11590509
109TET1_21451524_ChIP-Seq_MESCs_Mouse1.11108590
110* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09918331
111* GATA1_19941827_ChIP-Seq_MEL_Mouse1.09410032
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06744583
113GATA4_25053715_ChIP-Seq_YYC3_Human1.06071488
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05780799
115KLF5_25053715_ChIP-Seq_YYC3_Human1.05161922
116* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04957648
117SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04153074
118CDX2_20551321_ChIP-Seq_CACO-2_Human1.03892233
119* P68_20966046_ChIP-Seq_HELA_Human1.03559985
120PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02476843
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02102311
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01811176
123STAT1_20625510_ChIP-Seq_HELA_Human1.01206531
124PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00526973
125PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99583469
126PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98846111
127TP63_22573176_ChIP-Seq_HFKS_Human0.98695318
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.98570836
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98293342
130ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98195261
131SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97562231
132KDM5A_27292631_Chip-Seq_BREAST_Human0.97515472
133* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97256465
134* BCL6_27268052_Chip-Seq_Bcells_Human0.95884962
135* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95645133
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95008063
137* BCOR_27268052_Chip-Seq_Bcells_Human0.93692336
138CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92764834
139SMC4_20622854_ChIP-Seq_HELA_Human0.92696261
140HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91798411
141UBF1/2_26484160_Chip-Seq_HMECs_Human0.91365077
142RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90962794
143TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90925589
144PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88588969
145* GATA2_19941826_ChIP-Seq_K562_Human0.87922919
146TFEB_21752829_ChIP-Seq_HELA_Human0.85922946
147RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81048604
148* NCOR1_26117541_ChIP-Seq_K562_Human0.80786567
149GATA2_21666600_ChIP-Seq_HMVEC_Human0.78603706
150VDR_23849224_ChIP-Seq_CD4+_Human0.78586463
151CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.74818670
152VDR_24787735_ChIP-Seq_THP-1_Human0.74335662
153FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73862470
154CIITA_25753668_ChIP-Seq_RAJI_Human0.73511538
155ETS1_22383799_ChIP-Seq_G1ME_Mouse0.73422398
156* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72507297
157GATA1_22025678_ChIP-Seq_K562_Human0.72368554

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination3.35090709
2MP0002796_impaired_skin_barrier3.32920341
3MP0004264_abnormal_extraembryonic_tissu3.28148081
4MP0003763_abnormal_thymus_physiology3.22116013
5MP0010234_abnormal_vibrissa_follicle3.21239771
6MP0005671_abnormal_response_to3.08179076
7MP0006082_CNS_inflammation3.06788043
8MP0005083_abnormal_biliary_tract2.87486437
9MP0001835_abnormal_antigen_presentation2.77162064
10MP0005000_abnormal_immune_tolerance2.71759458
11MP0005058_abnormal_lysosome_morphology2.59172701
12MP0000685_abnormal_immune_system2.57378175
13MP0001800_abnormal_humoral_immune2.54704785
14MP0001790_abnormal_immune_system2.47965036
15MP0005387_immune_system_phenotype2.47965036
16MP0009840_abnormal_foam_cell2.47584290
17MP0001873_stomach_inflammation2.47554645
18MP0005025_abnormal_response_to2.46071721
19MP0002723_abnormal_immune_serum2.45524354
20MP0002420_abnormal_adaptive_immunity2.42797399
21MP0001819_abnormal_immune_cell2.39013605
22MP0009333_abnormal_splenocyte_physiolog2.36277667
23MP0002452_abnormal_antigen_presenting2.35751332
24MP0003950_abnormal_plasma_membrane2.31357317
25MP0002419_abnormal_innate_immunity2.30906055
26MP0003866_abnormal_defecation2.30855544
27MP0000465_gastrointestinal_hemorrhage2.28119361
28MP0003436_decreased_susceptibility_to2.24813522
29MP0002098_abnormal_vibrissa_morphology2.22701472
30MP0009785_altered_susceptibility_to2.19547822
31MP0002148_abnormal_hypersensitivity_rea2.17687726
32MP0005501_abnormal_skin_physiology2.17228693
33MP0002396_abnormal_hematopoietic_system2.15135166
34MP0010155_abnormal_intestine_physiology2.15074671
35MP0003724_increased_susceptibility_to2.10117663
36MP0002398_abnormal_bone_marrow2.09107520
37MP0000716_abnormal_immune_system2.02769407
38MP0003303_peritoneal_inflammation2.01894876
39MP0002877_abnormal_melanocyte_morpholog1.99539985
40MP0002405_respiratory_system_inflammati1.99107267
41MP0005464_abnormal_platelet_physiology1.99073638
42MP0001216_abnormal_epidermal_layer1.97316230
43MP0004947_skin_inflammation1.94046890
44MP0003300_gastrointestinal_ulcer1.90774371
45MP0005075_abnormal_melanosome_morpholog1.82961463
46MP0003172_abnormal_lysosome_physiology1.82537014
47MP0000689_abnormal_spleen_morphology1.82464156
48MP0008875_abnormal_xenobiotic_pharmacok1.80019724
49MP0004782_abnormal_surfactant_physiolog1.76899531
50MP0004381_abnormal_hair_follicle1.76137456
51MP0002722_abnormal_immune_system1.74275289
52MP0003690_abnormal_glial_cell1.72174716
53MP0005174_abnormal_tail_pigmentation1.70614102
54MP0003566_abnormal_cell_adhesion1.67487146
55MP0002429_abnormal_blood_cell1.67382395
56MP0000604_amyloidosis1.66080627
57MP0001851_eye_inflammation1.63740166
58MP0005310_abnormal_salivary_gland1.63578178
59MP0000678_abnormal_parathyroid_gland1.56254464
60MP0000427_abnormal_hair_cycle1.54692450
61MP0000490_abnormal_crypts_of1.54147733
62MP0002933_joint_inflammation1.53160144
63MP0005076_abnormal_cell_differentiation1.52140458
64MP0001845_abnormal_inflammatory_respons1.52033693
65MP0009780_abnormal_chondrocyte_physiolo1.51959901
66MP0001881_abnormal_mammary_gland1.51374650
67MP0000703_abnormal_thymus_morphology1.50643614
68MP0000627_abnormal_mammary_gland1.50009884
69MP0002060_abnormal_skin_morphology1.48488533
70MP0002166_altered_tumor_susceptibility1.43386080
71MP0003183_abnormal_peptide_metabolism1.34046027
72MP0000377_abnormal_hair_follicle1.31576852
73MP0000579_abnormal_nail_morphology1.28526711
74MP0003329_amyloid_beta_deposits1.26052586
75MP0001533_abnormal_skeleton_physiology1.25751796
76MP0005451_abnormal_body_composition1.24486988
77MP0002254_reproductive_system_inflammat1.24338337
78MP0010771_integument_phenotype1.21212683
79MP0005165_increased_susceptibility_to1.17568107
80MP0002006_tumorigenesis1.17503652
81MP0001663_abnormal_digestive_system1.16523946
82MP0009278_abnormal_bone_marrow1.16217381
83MP0004147_increased_porphyrin_level1.15718158
84MP0001666_abnormal_nutrient_absorption1.15468700
85MP0005023_abnormal_wound_healing1.15046050
86MP0005397_hematopoietic_system_phenotyp1.13696506
87MP0001545_abnormal_hematopoietic_system1.13696506
88MP0009931_abnormal_skin_appearance1.12022234
89MP0003448_altered_tumor_morphology1.11860440
90MP0003941_abnormal_skin_development1.11576360
91MP0003191_abnormal_cellular_cholesterol1.10866500
92MP0008469_abnormal_protein_level1.09837786
93MP0000371_diluted_coat_color1.06577389
94MP0003656_abnormal_erythrocyte_physiolo1.06541675
95MP0005164_abnormal_response_to1.04256052
96MP0001243_abnormal_dermal_layer1.04010849
97MP0004510_myositis1.03060081
98MP0003453_abnormal_keratinocyte_physiol1.02912233
99MP0003705_abnormal_hypodermis_morpholog1.01760676
100MP0000467_abnormal_esophagus_morphology1.01473482
101MP0010678_abnormal_skin_adnexa1.01172794
102MP0000383_abnormal_hair_follicle1.00708875
103MP0003045_fibrosis0.98432827
104MP0005381_digestive/alimentary_phenotyp0.96504494
105MP0003634_abnormal_glial_cell0.96161016
106MP0001765_abnormal_ion_homeostasis0.95696826
107MP0004233_abnormal_muscle_weight0.95579090
108MP0000538_abnormal_urinary_bladder0.95032556
109MP0001727_abnormal_embryo_implantation0.94714438
110MP0000343_altered_response_to0.94547084
111MP0000367_abnormal_coat/_hair0.90988488
112MP0001191_abnormal_skin_condition0.89590918
113MP0005409_darkened_coat_color0.88096571
114MP0003806_abnormal_nucleotide_metabolis0.87780444
115MP0004742_abnormal_vestibular_system0.86879140
116MP0009764_decreased_sensitivity_to0.86830059
117MP0001853_heart_inflammation0.85335345
118MP0002168_other_aberrant_phenotype0.83956358
119MP0000477_abnormal_intestine_morphology0.83955638
120MP0004019_abnormal_vitamin_homeostasis0.83827288
121MP0009643_abnormal_urine_homeostasis0.82090798
122MP0002998_abnormal_bone_remodeling0.82077458
123MP0008057_abnormal_DNA_replication0.81179670
124MP0003878_abnormal_ear_physiology0.81169117
125MP0005377_hearing/vestibular/ear_phenot0.81169117
126MP0003638_abnormal_response/metabolism_0.80363980
127MP0001542_abnormal_bone_strength0.80163201
128MP0002896_abnormal_bone_mineralization0.79665572
129MP0000015_abnormal_ear_pigmentation0.78087819
130MP0004185_abnormal_adipocyte_glucose0.77773681
131MP0008873_increased_physiological_sensi0.77377472
132MP0005390_skeleton_phenotype0.77043807
133MP0002019_abnormal_tumor_incidence0.74226890
134MP0009765_abnormal_xenobiotic_induced0.73994803
135MP0008260_abnormal_autophagy0.73272988
136MP0000858_altered_metastatic_potential0.72498517
137MP0001348_abnormal_lacrimal_gland0.69922231
138MP0004808_abnormal_hematopoietic_stem0.69781468
139MP0002229_neurodegeneration0.67591812
140MP0000470_abnormal_stomach_morphology0.66569052
141MP0003075_altered_response_to0.66409003
142MP0009763_increased_sensitivity_to0.65764124
143MP0005166_decreased_susceptibility_to0.63107382
144MP0001905_abnormal_dopamine_level0.59309047
145MP0003632_abnormal_nervous_system0.57961611
146MP0010352_gastrointestinal_tract_polyps0.55935093
147MP0001485_abnormal_pinna_reflex0.55170228
148MP0001849_ear_inflammation0.54452989
149MP0002095_abnormal_skin_pigmentation0.54292002

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.57239033
2Stomatitis (HP:0010280)4.49362894
3T lymphocytopenia (HP:0005403)4.48168743
4Chronic otitis media (HP:0000389)4.31795174
5Abnormality of T cell number (HP:0011839)4.18835471
6Recurrent abscess formation (HP:0002722)4.15294837
7Recurrent fungal infections (HP:0002841)3.84435141
8Recurrent viral infections (HP:0004429)3.78088214
9Eczematoid dermatitis (HP:0000976)3.73700841
10Abnormality of macrophages (HP:0004311)3.72586638
11Vacuolated lymphocytes (HP:0001922)3.64782713
12Neurofibrillary tangles (HP:0002185)3.60870049
13Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.60057223
14Peripheral hypomyelination (HP:0007182)3.57015225
15Abnormality of nail color (HP:0100643)3.50635135
16Abnormality of mucopolysaccharide metabolism (HP:0011020)3.46778478
17Abnormality of polysaccharide metabolism (HP:0011012)3.46778478
18Abnormality of glycosaminoglycan metabolism (HP:0004371)3.46778478
19Degeneration of the lateral corticospinal tracts (HP:0002314)3.46314443
20Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.46314443
21Recurrent bacterial skin infections (HP:0005406)3.45630950
22Pustule (HP:0200039)3.38894325
23Combined immunodeficiency (HP:0005387)3.35510009
24J-shaped sella turcica (HP:0002680)3.35187456
25Severe combined immunodeficiency (HP:0004430)3.34425720
26Increased cerebral lipofuscin (HP:0011813)3.32343782
27IgM deficiency (HP:0002850)3.31007597
28Abnormality of T cells (HP:0002843)3.23420882
29Recurrent skin infections (HP:0001581)3.22374715
30Urinary glycosaminoglycan excretion (HP:0003541)3.19584362
31Mucopolysacchariduria (HP:0008155)3.19584362
32Petechiae (HP:0000967)3.15640267
33Increased neuronal autofluorescent lipopigment (HP:0002074)3.11068877
34Slow saccadic eye movements (HP:0000514)3.09402629
35Autoimmune thrombocytopenia (HP:0001973)3.03578255
36Axonal loss (HP:0003447)2.99240757
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.96891527
38Cerebral hypomyelination (HP:0006808)2.94544230
39Recurrent bronchitis (HP:0002837)2.94134322
40Leukocytosis (HP:0001974)2.93122838
41Pili torti (HP:0003777)2.92024472
42Hepatosplenomegaly (HP:0001433)2.91814494
43Recurrent cutaneous fungal infections (HP:0011370)2.91211116
44Chronic mucocutaneous candidiasis (HP:0002728)2.91211116
45Myositis (HP:0100614)2.85439687
46Congenital ichthyosiform erythroderma (HP:0007431)2.84198276
47Abnormality of eosinophils (HP:0001879)2.83695910
48Increased IgE level (HP:0003212)2.83408528
49Onycholysis (HP:0001806)2.83118233
50Chronic diarrhea (HP:0002028)2.79722295
51Premature skin wrinkling (HP:0100678)2.78261806
52Loss of speech (HP:0002371)2.77511976
53Parakeratosis (HP:0001036)2.77204686
54Obstructive lung disease (HP:0006536)2.76484123
55Chronic obstructive pulmonary disease (HP:0006510)2.76484123
56Onion bulb formation (HP:0003383)2.75835769
57Thin bony cortex (HP:0002753)2.74873665
58Abnormality of glycolipid metabolism (HP:0010969)2.72716804
59Abnormality of liposaccharide metabolism (HP:0010968)2.72716804
60Abnormality of glycosphingolipid metabolism (HP:0004343)2.72716804
61Short nail (HP:0001799)2.70380315
62Thick nail (HP:0001805)2.68643217
63Concave nail (HP:0001598)2.67624046
64Sensory axonal neuropathy (HP:0003390)2.67129195
65Panhypogammaglobulinemia (HP:0003139)2.64932583
66Segmental peripheral demyelination/remyelination (HP:0003481)2.64497518
67Abnormality of the distal phalanges of the toes (HP:0010182)2.61074275
68Hypokinesia (HP:0002375)2.58571380
69Autoimmune hemolytic anemia (HP:0001890)2.58412615
70Abnormal respiratory epithelium morphology (HP:0012253)2.56112883
71Abnormal respiratory motile cilium morphology (HP:0005938)2.56112883
72Abnormality of T cell physiology (HP:0011840)2.56051481
73Eosinophilia (HP:0001880)2.55587640
74Interstitial pulmonary disease (HP:0006530)2.55173813
75Amelogenesis imperfecta (HP:0000705)2.53349927
76Nasal polyposis (HP:0100582)2.53331414
77Supranuclear gaze palsy (HP:0000605)2.51009032
78Cerebral inclusion bodies (HP:0100314)2.50929223
79Distal lower limb muscle weakness (HP:0009053)2.49246586
80Abnormal respiratory motile cilium physiology (HP:0012261)2.47533466
81Abnormal hair laboratory examination (HP:0003328)2.45295972
82Inflammation of the large intestine (HP:0002037)2.44782815
83Absent/shortened dynein arms (HP:0200106)2.44715924
84Dynein arm defect of respiratory motile cilia (HP:0012255)2.44715924
85Vasculitis (HP:0002633)2.44196210
86Gastrointestinal stroma tumor (HP:0100723)2.40625181
87Micronodular cirrhosis (HP:0001413)2.40274409
88Thyroiditis (HP:0100646)2.40228057
89Lymphopenia (HP:0001888)2.39163304
90Right ventricular cardiomyopathy (HP:0011663)2.37799658
91Purpura (HP:0000979)2.36803698
92Dysostosis multiplex (HP:0000943)2.35633686
93Abnormality of the corticospinal tract (HP:0002492)2.35574365
94Rhinitis (HP:0012384)2.35089597
95Chronic bronchitis (HP:0004469)2.31953205
96Abnormal ciliary motility (HP:0012262)2.31884347
97Abnormal delayed hypersensitivity skin test (HP:0002963)2.30203958
98Granulocytopenia (HP:0001913)2.29999597
99Abdominal distention (HP:0003270)2.29810632
100Cervical subluxation (HP:0003308)2.28538460
101Sparse lateral eyebrow (HP:0005338)2.27234149
102Cellulitis (HP:0100658)2.26448436
103Gastrointestinal inflammation (HP:0004386)2.26075754
104Abnormality of cells of the lymphoid lineage (HP:0012140)2.26028711
105Abnormal auditory evoked potentials (HP:0006958)2.25211773
106IgG deficiency (HP:0004315)2.25046354
107Alopecia of scalp (HP:0002293)2.23105653
108Cardiomegaly (HP:0001640)2.22182352
109Hypergammaglobulinemia (HP:0010702)2.20913622
110Fragile nails (HP:0001808)2.20233268
111Spontaneous hematomas (HP:0007420)2.19737185
112Vertebral compression fractures (HP:0002953)2.18250451
113Peripheral demyelination (HP:0011096)2.15627658
114Nail dystrophy (HP:0008404)2.15577435
115Abnormality of B cell number (HP:0010975)2.15441308
116B lymphocytopenia (HP:0010976)2.15441308
117Plantar hyperkeratosis (HP:0007556)2.15220900
118Osteolytic defects of the hand bones (HP:0009699)2.13838507
119Osteolytic defects of the phalanges of the hand (HP:0009771)2.13838507
120Clumsiness (HP:0002312)2.12037531
121Ileus (HP:0002595)2.11875195
122Mediastinal lymphadenopathy (HP:0100721)2.11679796
123Progressive neurologic deterioration (HP:0002344)2.11304483
124Meningitis (HP:0001287)2.11119200
125Gingival bleeding (HP:0000225)2.11006210
126Lymphoma (HP:0002665)2.08397014
127Cheilitis (HP:0100825)2.07805606
128Spastic paraparesis (HP:0002313)2.05298381
129Protuberant abdomen (HP:0001538)2.04414008
130Abnormal platelet volume (HP:0011876)2.04316621
131Prolonged bleeding time (HP:0003010)2.02260197
132Bronchiectasis (HP:0002110)2.01512480
133Abnormality of the nasal mucosa (HP:0000433)2.01127198
134Spastic tetraparesis (HP:0001285)1.99902940
135Disinhibition (HP:0000734)1.99013387
136Cone-rod dystrophy (HP:0000548)1.98765208
137Testicular atrophy (HP:0000029)1.97885313
138Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.97813542
139Rough bone trabeculation (HP:0100670)1.96514100
140Bone pain (HP:0002653)1.93684702
141Severe short stature (HP:0003510)1.93597152
142Milia (HP:0001056)1.91916568
143Fatigue (HP:0012378)1.91884729
144Epistaxis (HP:0000421)1.91751653
145Abnormal trabecular bone morphology (HP:0100671)1.90625815
146Lip pit (HP:0100267)1.89421678
147Male infertility (HP:0003251)1.88976833
148Gingivitis (HP:0000230)1.87408024
149Ridged nail (HP:0001807)1.86933143
150Diaphragmatic weakness (HP:0009113)1.86237007
151Increased serum ferritin (HP:0003281)1.85584066
152Vascular calcification (HP:0004934)1.85484455
153Restrictive lung disease (HP:0002091)1.84536940
154Abnormality of iron homeostasis (HP:0011031)1.84262762
155Atrophic scars (HP:0001075)1.84066897
156Spastic gait (HP:0002064)1.83751236
157Sparse eyelashes (HP:0000653)1.81986130
158Abnormality of transition element cation homeostasis (HP:0011030)1.81890414
159Stridor (HP:0010307)1.81554526
160Malnutrition (HP:0004395)1.81495486
161Thrombocytosis (HP:0001894)1.80883403
162Hydroxyprolinuria (HP:0003080)1.80797666
163Abnormality of proline metabolism (HP:0010907)1.80797666
164Deformed sella turcica (HP:0002681)1.80297573
165Joint stiffness (HP:0001387)1.79636806
166Upper limb amyotrophy (HP:0009129)1.79437224
167Distal upper limb amyotrophy (HP:0007149)1.79437224
168Abnormal blistering of the skin (HP:0008066)1.77559382
169Subcapsular cataract (HP:0000523)1.77430361
170Tongue fasciculations (HP:0001308)1.76415085
171Woolly hair (HP:0002224)1.75330268
172Flat acetabular roof (HP:0003180)1.75251182
173Type I transferrin isoform profile (HP:0003642)1.74440057
174Abnormality of the frontal sinuses (HP:0002687)1.73836426
175Aplasia cutis congenita (HP:0001057)1.70289308
176Palmoplantar hyperkeratosis (HP:0000972)1.69668705
177Hyperparathyroidism (HP:0000843)1.67188496
178Septate vagina (HP:0001153)1.66680425
179Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.66644548
180Abnormality of small intestinal villus morphology (HP:0011472)1.66534358
181Villous atrophy (HP:0011473)1.66534358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.38773112
2MST1R4.77889852
3MAP4K14.77566391
4TXK3.43292897
5EPHB13.23824225
6IRAK33.14542802
7MAPKAPK33.03892594
8STK392.81117495
9STK102.69865049
10TRIB32.55082841
11TESK22.52504173
12SIK12.40546167
13ITK2.39624309
14ERN12.37107528
15PAK42.33374666
16MST42.25700027
17KIT2.12275392
18BLK2.08001644
19RPS6KB22.05738365
20GRK62.03086589
21TESK11.99331599
22MAPKAPK51.93553711
23ZAP701.90412641
24OXSR11.88299039
25IKBKE1.87998304
26JAK31.85922398
27TYK21.81905883
28SMG11.81847552
29CLK11.80398945
30SCYL21.74990808
31CDK191.71231960
32PKN21.69567622
33EIF2AK11.69349089
34TBK11.67426044
35LCK1.67397401
36MAPK151.59780006
37IRAK41.51805411
38CSK1.49795935
39BTK1.43009501
40PRKCI1.38972127
41PTK21.38711139
42MAP3K141.36268660
43MAP3K131.36054154
44PBK1.33193026
45NLK1.32892354
46PKN11.31660752
47TRPM71.28726023
48EEF2K1.25894841
49TEC1.24251721
50NME21.22798906
51PRKCQ1.21214391
52TLK11.20923816
53CHUK1.20013294
54FGR1.19871136
55MAP3K31.17635555
56CSF1R1.17394542
57HCK1.16454479
58PIM21.11437917
59SYK1.08994334
60CSNK1G31.08879019
61LRRK21.07388391
62IKBKB1.07349393
63MAP3K121.05805669
64ABL21.03482660
65RPS6KA21.03125812
66FER0.97987078
67CSNK1A1L0.94941758
68ICK0.94821935
69PTK60.93248034
70FES0.93027394
71CSNK1G10.90094027
72FGFR40.89931350
73PIM10.89193308
74JAK10.88985998
75CDK120.86948301
76VRK20.86493998
77TGFBR20.82743529
78MAP2K20.82196310
79MARK20.81272621
80CDK70.80202912
81ROCK20.79700385
82TYRO30.79337533
83STK160.78099576
84STK40.75767365
85MAP3K80.75627564
86NME10.74207298
87TNIK0.73999893
88PRKCH0.73921784
89LYN0.73183489
90JAK20.71556456
91RPS6KA50.71376864
92MET0.71163582
93SIK30.67136715
94NEK60.66264426
95FYN0.65307323
96MAP2K60.64723173
97HIPK20.63707288
98TAOK20.63472883
99TAOK30.63437617
100PDK10.63072626
101MATK0.60414585
102RIPK40.60282945
103CAMK2B0.60047187
104LIMK10.59156132
105RAF10.58250751
106GRK70.57596572
107PRKG20.56581338
108CSNK1G20.56156731
109LMTK20.55451315
110ADRBK20.55243013
111RPS6KC10.55234942
112RPS6KL10.55234942
113RPS6KA60.54284087
114PDGFRB0.53890958
115ALK0.51385835
116PDPK10.50259589
117MAP3K110.49891786
118STK380.48321779
119MAP2K30.46857280
120MAP3K70.46226079
121BMX0.46217693
122PRKD10.43349232
123MAPKAPK20.42538154
124MAP3K100.42251971
125PTK2B0.41690752
126ABL10.41439724
127ILK0.40973478
128ERBB40.39503086
129MAP2K10.39180345
130TAOK10.38455466
131BRSK20.38132770
132CAMK2G0.38020129
133PRKD20.37906930
134MAPK40.37230532
135MARK30.37190460
136BMPR20.36566734
137PAK10.36420036
138WNK10.35666775
139TNK20.35342657
140EGFR0.34665256
141YES10.34310158
142UHMK10.34231907
143KDR0.33920172
144MTOR0.33822582
145ERBB20.33620801
146MUSK0.33324521
147FGFR20.33191009
148EIF2AK30.32765433
149FGFR30.31674051
150ADRBK10.31639569
151MAPK70.30806240
152CDC42BPA0.30754820
153BUB10.30552044
154GSK3A0.29414431
155CSNK1D0.27650907
156DAPK10.27394351
157DMPK0.27011730
158MELK0.26913352

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.59558980
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.66406922
3T cell receptor signaling pathway_Homo sapiens_hsa046602.51691923
4Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.42319476
5Steroid biosynthesis_Homo sapiens_hsa001002.27752983
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.23528348
7N-Glycan biosynthesis_Homo sapiens_hsa005102.10391090
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.09720623
9Hematopoietic cell lineage_Homo sapiens_hsa046402.05950406
10Bladder cancer_Homo sapiens_hsa052192.03263968
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.02911060
12Leishmaniasis_Homo sapiens_hsa051402.00685127
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90732510
14Fructose and mannose metabolism_Homo sapiens_hsa000511.89780632
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.89565356
16Measles_Homo sapiens_hsa051621.89195220
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.87666761
18B cell receptor signaling pathway_Homo sapiens_hsa046621.86501082
19Lysosome_Homo sapiens_hsa041421.80794372
20Osteoclast differentiation_Homo sapiens_hsa043801.80552762
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.79337476
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76515663
23Allograft rejection_Homo sapiens_hsa053301.75827465
24Asthma_Homo sapiens_hsa053101.73987841
25Other glycan degradation_Homo sapiens_hsa005111.72628924
26Ether lipid metabolism_Homo sapiens_hsa005651.71527031
27Sphingolipid metabolism_Homo sapiens_hsa006001.70261883
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62159761
29Antigen processing and presentation_Homo sapiens_hsa046121.59309023
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57404737
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.56575329
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47870419
33Graft-versus-host disease_Homo sapiens_hsa053321.46040761
34Fatty acid elongation_Homo sapiens_hsa000621.44275641
35Galactose metabolism_Homo sapiens_hsa000521.41891895
36Autoimmune thyroid disease_Homo sapiens_hsa053201.41748691
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.41585967
38Shigellosis_Homo sapiens_hsa051311.39201642
39Malaria_Homo sapiens_hsa051441.37108836
40Collecting duct acid secretion_Homo sapiens_hsa049661.34260036
41Renin-angiotensin system_Homo sapiens_hsa046141.32185369
42Vibrio cholerae infection_Homo sapiens_hsa051101.31389303
43Folate biosynthesis_Homo sapiens_hsa007901.28468189
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.26518968
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.25853262
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25718936
47Chemokine signaling pathway_Homo sapiens_hsa040621.21913355
48Salmonella infection_Homo sapiens_hsa051321.20189779
49Pertussis_Homo sapiens_hsa051331.17793326
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16135970
51Sphingolipid signaling pathway_Homo sapiens_hsa040711.15911758
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15911484
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10777608
54Mineral absorption_Homo sapiens_hsa049781.09134117
55Apoptosis_Homo sapiens_hsa042101.08338810
56Tuberculosis_Homo sapiens_hsa051521.07590293
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07415084
58Toxoplasmosis_Homo sapiens_hsa051451.06595473
59Sulfur metabolism_Homo sapiens_hsa009201.06375396
60ABC transporters_Homo sapiens_hsa020101.05702722
61Hepatitis C_Homo sapiens_hsa051601.04369991
62Acute myeloid leukemia_Homo sapiens_hsa052211.03980811
63Histidine metabolism_Homo sapiens_hsa003401.02174162
64Fat digestion and absorption_Homo sapiens_hsa049751.01924536
65Herpes simplex infection_Homo sapiens_hsa051681.00407778
66Proteasome_Homo sapiens_hsa030500.99990431
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98486824
68Rheumatoid arthritis_Homo sapiens_hsa053230.91029766
69Influenza A_Homo sapiens_hsa051640.90883029
70Endocytosis_Homo sapiens_hsa041440.90232567
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89387022
72Platelet activation_Homo sapiens_hsa046110.88825064
73Sulfur relay system_Homo sapiens_hsa041220.88678803
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88619282
75Hepatitis B_Homo sapiens_hsa051610.87155550
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85761663
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.85552947
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84602669
79Linoleic acid metabolism_Homo sapiens_hsa005910.83615236
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83132765
81Non-homologous end-joining_Homo sapiens_hsa034500.82542788
82Ribosome_Homo sapiens_hsa030100.80972975
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80942057
84Small cell lung cancer_Homo sapiens_hsa052220.80127382
85Vitamin digestion and absorption_Homo sapiens_hsa049770.79594958
86Chemical carcinogenesis_Homo sapiens_hsa052040.78998993
87Caffeine metabolism_Homo sapiens_hsa002320.77059593
88Thyroid cancer_Homo sapiens_hsa052160.76551392
89TNF signaling pathway_Homo sapiens_hsa046680.75606713
90Legionellosis_Homo sapiens_hsa051340.73156647
91Phenylalanine metabolism_Homo sapiens_hsa003600.71202952
92Viral carcinogenesis_Homo sapiens_hsa052030.70444337
93Staphylococcus aureus infection_Homo sapiens_hsa051500.69237796
94Renal cell carcinoma_Homo sapiens_hsa052110.67322655
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65564540
96Viral myocarditis_Homo sapiens_hsa054160.65416109
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65214828
98DNA replication_Homo sapiens_hsa030300.64569172
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64378480
100Pancreatic cancer_Homo sapiens_hsa052120.63878395
101* Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63677717
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63178999
103Pancreatic secretion_Homo sapiens_hsa049720.60450678
104Protein export_Homo sapiens_hsa030600.60327258
105VEGF signaling pathway_Homo sapiens_hsa043700.59911913
106Proteoglycans in cancer_Homo sapiens_hsa052050.59823647
107Phagosome_Homo sapiens_hsa041450.59096118
108Notch signaling pathway_Homo sapiens_hsa043300.57676644
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.56293365
110Inositol phosphate metabolism_Homo sapiens_hsa005620.54183682
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53264159
112Insulin resistance_Homo sapiens_hsa049310.52717944
113Epstein-Barr virus infection_Homo sapiens_hsa051690.52190370
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.51546052
115Tyrosine metabolism_Homo sapiens_hsa003500.50700372
116Chronic myeloid leukemia_Homo sapiens_hsa052200.48796477
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.47760423
118Amoebiasis_Homo sapiens_hsa051460.44965505
119Non-small cell lung cancer_Homo sapiens_hsa052230.44667289
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44412913
121Vitamin B6 metabolism_Homo sapiens_hsa007500.43580851
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42854696
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42042661
124Endometrial cancer_Homo sapiens_hsa052130.41958961
125Glycerolipid metabolism_Homo sapiens_hsa005610.41937848
126Pyrimidine metabolism_Homo sapiens_hsa002400.41142365
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40497753
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40447430
129Glutathione metabolism_Homo sapiens_hsa004800.39953530
130Mismatch repair_Homo sapiens_hsa034300.39371266
131Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38889007
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38714207
133Selenocompound metabolism_Homo sapiens_hsa004500.37647016
134Pentose phosphate pathway_Homo sapiens_hsa000300.36196998
135Choline metabolism in cancer_Homo sapiens_hsa052310.35030851

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