GALNT7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. This enzyme is a type II transmembrane protein and shares common sequence motifs with other family members. Unlike other family members, this enzyme shows exclusive specificity for partially GalNAc-glycosylated acceptor substrates and shows no activity with non-glycosylated peptides. This protein may function as a follow-up enzyme in the initiation step of O-glycosylation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1V(D)J recombination (GO:0033151)5.96327359
2DNA unwinding involved in DNA replication (GO:0006268)5.87884507
3nuclear pore complex assembly (GO:0051292)5.53167025
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.44292411
5nuclear pore organization (GO:0006999)5.21939888
6DNA topological change (GO:0006265)5.12070183
7negative regulation of thymocyte apoptotic process (GO:0070244)4.87605270
8protein localization to kinetochore (GO:0034501)4.79796985
9sister chromatid segregation (GO:0000819)4.59275884
10mitotic metaphase plate congression (GO:0007080)4.51071240
11neutrophil activation involved in immune response (GO:0002283)4.34161124
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.31777450
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.31777450
14modulation by symbiont of host immune response (GO:0052553)4.31777450
15positive regulation by symbiont of host defense response (GO:0052509)4.31777450
16modulation by symbiont of host defense response (GO:0052031)4.31777450
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.31777450
18establishment of integrated proviral latency (GO:0075713)4.29392365
19protein localization to chromosome, centromeric region (GO:0071459)4.20708530
20pre-miRNA processing (GO:0031054)4.18289750
21mitotic sister chromatid cohesion (GO:0007064)4.16493580
22ribosome assembly (GO:0042255)4.13206198
23metaphase plate congression (GO:0051310)4.10947023
24mitotic sister chromatid segregation (GO:0000070)4.02795118
25hepatocyte apoptotic process (GO:0097284)3.97890668
26pore complex assembly (GO:0046931)3.94816412
27somatic cell DNA recombination (GO:0016444)3.89145321
28somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.89145321
29DNA strand elongation involved in DNA replication (GO:0006271)3.87158103
30IMP biosynthetic process (GO:0006188)3.83377342
31regulation of interferon-beta biosynthetic process (GO:0045357)3.78806566
32positive regulation of gamma-delta T cell activation (GO:0046645)3.74206073
33CENP-A containing nucleosome assembly (GO:0034080)3.69899313
34chromatin remodeling at centromere (GO:0031055)3.69868501
35DNA strand elongation (GO:0022616)3.67095407
36mitotic recombination (GO:0006312)3.66198580
37positive regulation of interferon-alpha production (GO:0032727)3.61679923
38IMP metabolic process (GO:0046040)3.52869191
39antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.52621833
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.52621833
41DNA duplex unwinding (GO:0032508)3.52536761
42somatic diversification of immune receptors (GO:0002200)3.51247051
43antigen processing and presentation of endogenous antigen (GO:0019883)3.49476543
44heterochromatin organization (GO:0070828)3.48868395
45regulation of interferon-alpha production (GO:0032647)3.48759347
46DNA ligation (GO:0006266)3.47390110
47mitotic nuclear envelope disassembly (GO:0007077)3.43180462
48natural killer cell mediated cytotoxicity (GO:0042267)3.42721073
49natural killer cell mediated immunity (GO:0002228)3.42721073
50DNA geometric change (GO:0032392)3.42408735
51establishment of chromosome localization (GO:0051303)3.42375602
52telomere maintenance via semi-conservative replication (GO:0032201)3.41823407
53neutrophil activation (GO:0042119)3.40653399
54mitotic chromosome condensation (GO:0007076)3.39354436
55DNA replication initiation (GO:0006270)3.29949868
56regulation of helicase activity (GO:0051095)3.26588900
57regulation of centriole replication (GO:0046599)3.25297085
58negative regulation of chromosome segregation (GO:0051985)3.22995422
59protein complex localization (GO:0031503)3.22882066
60negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.22069246
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.22069246
62negative regulation of mitotic sister chromatid segregation (GO:0033048)3.22069246
63negative regulation of mitotic sister chromatid separation (GO:2000816)3.22069246
64negative regulation of sister chromatid segregation (GO:0033046)3.22069246
65telomere maintenance via recombination (GO:0000722)3.22062234
66granulocyte activation (GO:0036230)3.21907526
67non-recombinational repair (GO:0000726)3.21094916
68double-strand break repair via nonhomologous end joining (GO:0006303)3.21094916
69purine nucleobase biosynthetic process (GO:0009113)3.20025565
70spindle checkpoint (GO:0031577)3.19439652
71establishment of viral latency (GO:0019043)3.18707443
72regulation of mitotic metaphase/anaphase transition (GO:0030071)3.18663492
73regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18663492
74intestinal epithelial cell development (GO:0060576)3.16093268
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.14436949
76mitotic spindle checkpoint (GO:0071174)3.14175219
77negative regulation of cell killing (GO:0031342)3.13265487
78negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.13265487
79mitotic G2/M transition checkpoint (GO:0044818)3.13112196
80regulation of chromosome segregation (GO:0051983)3.12063334
81positive regulation of chromosome segregation (GO:0051984)3.11774264
82histone exchange (GO:0043486)3.11702871
83membrane disassembly (GO:0030397)3.11330776
84nuclear envelope disassembly (GO:0051081)3.11330776
85response to host immune response (GO:0052572)3.11191478
86response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.11191478
87myeloid cell activation involved in immune response (GO:0002275)3.09475153
88response to hydroperoxide (GO:0033194)3.08986310
89respiratory burst (GO:0045730)3.08926062
90NIK/NF-kappaB signaling (GO:0038061)3.07852797
91DNA replication-independent nucleosome organization (GO:0034724)3.07569553
92DNA replication-independent nucleosome assembly (GO:0006336)3.07569553
93response to X-ray (GO:0010165)3.06736418
94cellular extravasation (GO:0045123)3.06606651
95regulation of sister chromatid segregation (GO:0033045)3.06404399
96regulation of mitotic sister chromatid separation (GO:0010965)3.06404399
97regulation of mitotic sister chromatid segregation (GO:0033047)3.06404399
98regulation of B cell receptor signaling pathway (GO:0050855)3.05509529
99regulation of histone H3-K9 methylation (GO:0051570)3.03022306
100macrophage activation involved in immune response (GO:0002281)3.01727297
101negative regulation of fibroblast apoptotic process (GO:2000270)3.01440916
102resolution of meiotic recombination intermediates (GO:0000712)3.01356941
103cellular protein complex localization (GO:0034629)3.00942102
104negative regulation of DNA repair (GO:0045738)3.00721734
105immunoglobulin mediated immune response (GO:0016064)2.99618279
106myeloid dendritic cell activation (GO:0001773)2.97913019
107mitotic G2 DNA damage checkpoint (GO:0007095)2.95813462
108mitotic spindle assembly checkpoint (GO:0007094)2.95578328
109formation of translation preinitiation complex (GO:0001731)2.95298290
110attachment of spindle microtubules to kinetochore (GO:0008608)2.93864996
111response to type I interferon (GO:0034340)2.92799692
112spindle assembly checkpoint (GO:0071173)2.92230835
113type I interferon signaling pathway (GO:0060337)2.91031058
114cellular response to type I interferon (GO:0071357)2.91031058
115positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.90269258
116regulation of sister chromatid cohesion (GO:0007063)2.88471169
117kinetochore organization (GO:0051383)2.87975387
118mast cell activation (GO:0045576)2.86770220
119DNA conformation change (GO:0071103)2.86646955
120hepatocyte differentiation (GO:0070365)2.86536744
121regulation of DNA endoreduplication (GO:0032875)2.85575671
122response to muramyl dipeptide (GO:0032495)2.85176644
123bundle of His cell to Purkinje myocyte communication (GO:0086069)2.84412155
124nucleotide-sugar biosynthetic process (GO:0009226)2.84041700
125positive regulation of antigen processing and presentation (GO:0002579)2.82671930
126response to host (GO:0075136)2.82319291
127response to host defenses (GO:0052200)2.82319291
128response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.82319291
129nucleobase biosynthetic process (GO:0046112)2.80718832
130positive regulation of SMAD protein import into nucleus (GO:0060391)2.79241432
131T cell migration (GO:0072678)2.77204297
132regulation of alpha-beta T cell proliferation (GO:0046640)2.75305233
133myeloid dendritic cell differentiation (GO:0043011)2.72946154
134ATP-dependent chromatin remodeling (GO:0043044)2.71897633
135Arp2/3 complex-mediated actin nucleation (GO:0034314)2.71060701
136negative regulation of B cell proliferation (GO:0030889)2.70434981
137regulation of gamma-delta T cell differentiation (GO:0045586)2.69157043
138regulation of T cell migration (GO:2000404)2.69014040
139lipopolysaccharide-mediated signaling pathway (GO:0031663)2.68455294
140DNA replication checkpoint (GO:0000076)2.67739776
141response to peptidoglycan (GO:0032494)2.67726648
142regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.67421171
143positive regulation of alpha-beta T cell proliferation (GO:0046641)2.67342953
144T cell differentiation in thymus (GO:0033077)2.65444089
145interferon-gamma-mediated signaling pathway (GO:0060333)2.64673503
146RNA-dependent DNA replication (GO:0006278)2.64040922
147regulation of gamma-delta T cell activation (GO:0046643)2.62925723
148tolerance induction (GO:0002507)2.62370408
149negative regulation of DNA-dependent DNA replication (GO:2000104)2.61333519
150dendritic cell migration (GO:0036336)2.60621944
151myeloid leukocyte activation (GO:0002274)2.60485169
152positive regulation of T cell migration (GO:2000406)2.58800488
153regulation of interleukin-12 biosynthetic process (GO:0045075)2.58436968
154regulation of RNA export from nucleus (GO:0046831)2.58433290
155defense response to protozoan (GO:0042832)2.57805154
156regulation of translation in response to stress (GO:0043555)2.57747172
157positive regulation of interferon-beta production (GO:0032728)2.57303580
158regulation of lymphocyte migration (GO:2000401)2.56536407
159regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.56034252
160regulation of mitotic spindle checkpoint (GO:1903504)2.56034252
161chromosome segregation (GO:0007059)2.54989944
162positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.54973133
163regulation of centrosome cycle (GO:0046605)2.54813229
164leukocyte degranulation (GO:0043299)2.54698212
165B cell mediated immunity (GO:0019724)2.54601544
166regulation of necroptotic process (GO:0060544)2.53660482
167positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.53472251
168regulation of translational fidelity (GO:0006450)2.52936684
169T-helper 1 type immune response (GO:0042088)2.52889618
170leukocyte cell-cell adhesion (GO:0007159)2.51375101
171leukocyte mediated cytotoxicity (GO:0001909)2.51222380
172regulation of T cell tolerance induction (GO:0002664)2.50046731
173regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.49977490
174dendritic cell chemotaxis (GO:0002407)2.49689713
175neutrophil mediated immunity (GO:0002446)2.49113291
176maintenance of gastrointestinal epithelium (GO:0030277)2.48810977
177leukocyte aggregation (GO:0070486)2.48792456
178monocyte chemotaxis (GO:0002548)2.48534107
179negative regulation of interleukin-17 production (GO:0032700)2.48217453
180microglial cell activation (GO:0001774)2.47179632
181dendritic cell differentiation (GO:0097028)2.45741043
182positive regulation of T cell cytokine production (GO:0002726)2.45150265
183B cell receptor signaling pathway (GO:0050853)2.44790080
184negative thymic T cell selection (GO:0045060)2.43765222
185regulation of T cell chemotaxis (GO:0010819)2.43630593
186positive regulation of T cell chemotaxis (GO:0010820)2.43630593
187positive regulation of interleukin-12 production (GO:0032735)2.42252858
188response to protozoan (GO:0001562)2.42184046
189negative T cell selection (GO:0043383)2.42078937
190regulation of T-helper 1 cell differentiation (GO:0045625)2.41865476
191I-kappaB phosphorylation (GO:0007252)2.37602521
192regulation of antigen processing and presentation (GO:0002577)2.36488783
193pinocytosis (GO:0006907)2.36089040
194regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.34769727
195myeloid cell homeostasis (GO:0002262)2.33912624
196interferon-gamma production (GO:0032609)2.32968395
197tumor necrosis factor-mediated signaling pathway (GO:0033209)2.32576337
198positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.31714980
199positive regulation of response to biotic stimulus (GO:0002833)2.31221701
200positive regulation of interleukin-2 production (GO:0032743)2.30246192

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.26387029
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.10800226
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.95453090
4E2F7_22180533_ChIP-Seq_HELA_Human4.38163280
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.53575132
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.48166592
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.25816481
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.24625685
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.21723267
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.20324743
11TP63_17297297_ChIP-ChIP_HaCaT_Human3.17987268
12BP1_19119308_ChIP-ChIP_Hs578T_Human3.16484863
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.15220474
14EGR1_19374776_ChIP-ChIP_THP-1_Human3.12871317
15SALL1_21062744_ChIP-ChIP_HESCs_Human3.08884691
16* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.07160068
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.01799483
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.95676855
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.74747328
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.69958869
21* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.53334033
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.51412752
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41218276
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26425953
25MYB_26560356_Chip-Seq_TH2_Human2.25796238
26* SPI1_23547873_ChIP-Seq_NB4_Human2.20640861
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18871677
28RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12467108
29MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12282911
30RUNX_20019798_ChIP-Seq_JUKART_Human2.09786676
31BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06866737
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.04482366
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00420419
34SCL_19346495_ChIP-Seq_HPC-7_Human2.00394149
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.00361350
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.96605717
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96229655
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93496043
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93372643
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86399410
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.84103101
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.82789754
43* MYB_26560356_Chip-Seq_TH1_Human1.82673247
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80322780
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77037740
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75380268
47PU_27001747_Chip-Seq_BMDM_Mouse1.74740743
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73894453
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72289403
50VDR_24763502_ChIP-Seq_THP-1_Human1.71751370
51MAF_26560356_Chip-Seq_TH1_Human1.71312736
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71221632
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.70642837
54KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.63276596
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.63276596
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.63276596
57VDR_21846776_ChIP-Seq_THP-1_Human1.59415037
58* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58728090
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.56860232
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55022564
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.54152907
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53259656
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53062529
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52524642
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.49373798
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49244708
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.49151359
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49072544
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48802423
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48493811
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45534173
72* CHD1_26751641_Chip-Seq_LNCaP_Human1.44106431
73* SPI1_23127762_ChIP-Seq_K562_Human1.43217773
74EWS_26573619_Chip-Seq_HEK293_Human1.41101687
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.38509554
76UTX_26944678_Chip-Seq_JUKART_Human1.36754936
77SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.36067184
78SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34332136
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33838709
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.33382246
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32280234
82GATA3_27048872_Chip-Seq_THYMUS_Human1.32143407
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31227563
84SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31227563
85VDR_24787735_ChIP-Seq_THP-1_Human1.30243106
86NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.29034633
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28467856
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27477414
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25850567
90GATA6_25053715_ChIP-Seq_YYC3_Human1.23420551
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23123740
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22006772
93MYC_22102868_ChIP-Seq_BL_Human1.21618911
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21605448
95FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20305361
96ELF5_23300383_ChIP-Seq_T47D_Human1.18822739
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18685414
98TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17955375
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17533408
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17251361
101* TCF7_22412390_ChIP-Seq_EML_Mouse1.16237271
102FOXP3_21729870_ChIP-Seq_TREG_Human1.16047600
103* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15957819
104* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15623006
105DCP1A_22483619_ChIP-Seq_HELA_Human1.15604191
106HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15429305
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14957706
108FOXO3_23340844_ChIP-Seq_DLD1_Human1.14257626
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13912637
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11758849
111TTF2_22483619_ChIP-Seq_HELA_Human1.10711665
112FUS_26573619_Chip-Seq_HEK293_Human1.10632822
113ELK1_19687146_ChIP-ChIP_HELA_Human1.10121250
114* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09346454
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08872455
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07690919
117CLOCK_20551151_ChIP-Seq_293T_Human1.07270699
118STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06646686
119* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06431063
120POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06231639
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05990504
122GATA1_22025678_ChIP-Seq_K562_Human1.05724499
123GATA3_26560356_Chip-Seq_TH2_Human1.05270957
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05243784
125SOX2_20726797_ChIP-Seq_SW620_Human1.04077246
126* GATA4_25053715_ChIP-Seq_YYC3_Human1.04051534
127KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03281716
128FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02954758
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02867793
130NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02831135
131ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02493583
132SOX2_16153702_ChIP-ChIP_HESCs_Human1.01939613
133SOX17_20123909_ChIP-Seq_XEN_Mouse1.00578506
134E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00113068
135CDX2_20551321_ChIP-Seq_CACO-2_Human1.00003967
136GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99368020
137VDR_23849224_ChIP-Seq_CD4+_Human0.99193646
138TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98717642
139* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98522638
140ZNF263_19887448_ChIP-Seq_K562_Human0.98424002
141FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98016797
142ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97814634
143WT1_19549856_ChIP-ChIP_CCG9911_Human0.96275214
144KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94232402
145TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93825254
146SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93428528
147GATA2_21666600_ChIP-Seq_HMVEC_Human0.92914719
148XRN2_22483619_ChIP-Seq_HELA_Human0.91139770
149POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90966609
150BRD4_25478319_ChIP-Seq_HGPS_Human0.90544395
151SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90222580
152TFEB_21752829_ChIP-Seq_HELA_Human0.89890018
153MYC_18940864_ChIP-ChIP_HL60_Human0.86811495
154CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86219820
155MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85274527
156TP63_19390658_ChIP-ChIP_HaCaT_Human0.84347156
157SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83730720
158MAF_26560356_Chip-Seq_TH2_Human0.83311320
159CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83242376
160KDM5A_27292631_Chip-Seq_BREAST_Human0.83221768
161CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83188675
162E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81083287
163CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80939040
164CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79676332
165E2F1_21310950_ChIP-Seq_MCF-7_Human0.79023577
166* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78012049
167AR_21909140_ChIP-Seq_LNCAP_Human0.77287209
168ELF1_17652178_ChIP-ChIP_JURKAT_Human0.76959868
169KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.76586134
170LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.76410633
171SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74879225
172ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74868018
173FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.72861949
174RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.72162295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.12746399
2MP0008057_abnormal_DNA_replication3.91214916
3MP0004957_abnormal_blastocyst_morpholog3.45165339
4MP0001835_abnormal_antigen_presentation3.44597410
5MP0003941_abnormal_skin_development3.41108794
6MP0009785_altered_susceptibility_to2.83978256
7MP0003436_decreased_susceptibility_to2.74586838
8MP0006082_CNS_inflammation2.70947817
9MP0002148_abnormal_hypersensitivity_rea2.64599026
10MP0005671_abnormal_response_to2.63750919
11MP0003303_peritoneal_inflammation2.60107435
12MP0005000_abnormal_immune_tolerance2.59813821
13MP0010155_abnormal_intestine_physiology2.52843432
14MP0001873_stomach_inflammation2.49300218
15MP0003111_abnormal_nucleus_morphology2.46534141
16MP0002452_abnormal_antigen_presenting2.46361889
17MP0000685_abnormal_immune_system2.45912526
18MP0003077_abnormal_cell_cycle2.45654529
19MP0003300_gastrointestinal_ulcer2.45488276
20MP0006054_spinal_hemorrhage2.45167696
21MP0001800_abnormal_humoral_immune2.41968169
22MP0003890_abnormal_embryonic-extraembry2.40600056
23MP0005025_abnormal_response_to2.40114195
24MP0002419_abnormal_innate_immunity2.37532218
25MP0000537_abnormal_urethra_morphology2.36824989
26MP0001790_abnormal_immune_system2.36228579
27MP0005387_immune_system_phenotype2.36228579
28MP0005058_abnormal_lysosome_morphology2.34169896
29MP0000490_abnormal_crypts_of2.33973509
30MP0009697_abnormal_copulation2.24443486
31MP0002723_abnormal_immune_serum2.23664937
32MP0008932_abnormal_embryonic_tissue2.18750524
33MP0001819_abnormal_immune_cell2.18080406
34MP0002166_altered_tumor_susceptibility2.16446181
35MP0002420_abnormal_adaptive_immunity2.16396767
36MP0010352_gastrointestinal_tract_polyps2.10319410
37MP0008004_abnormal_stomach_pH2.10122470
38MP0008058_abnormal_DNA_repair2.00518586
39MP0004947_skin_inflammation1.94415984
40MP0002132_abnormal_respiratory_system1.92514432
41MP0009333_abnormal_splenocyte_physiolog1.86700974
42MP0002006_tumorigenesis1.86519856
43MP0002277_abnormal_respiratory_mucosa1.83610473
44MP0002405_respiratory_system_inflammati1.81410026
45MP0010234_abnormal_vibrissa_follicle1.81219907
46MP0001730_embryonic_growth_arrest1.77684912
47MP0003866_abnormal_defecation1.74513394
48MP0003718_maternal_effect1.73650488
49MP0002398_abnormal_bone_marrow1.72271290
50MP0001845_abnormal_inflammatory_respons1.66822448
51MP0000716_abnormal_immune_system1.64731387
52MP0005310_abnormal_salivary_gland1.64436973
53MP0005464_abnormal_platelet_physiology1.59741081
54MP0003763_abnormal_thymus_physiology1.58744036
55MP0000465_gastrointestinal_hemorrhage1.57597646
56MP0000350_abnormal_cell_proliferation1.56613000
57MP0001672_abnormal_embryogenesis/_devel1.54328801
58MP0005380_embryogenesis_phenotype1.54328801
59MP0002877_abnormal_melanocyte_morpholog1.54204095
60MP0010307_abnormal_tumor_latency1.53695463
61MP0005174_abnormal_tail_pigmentation1.52964767
62MP0003448_altered_tumor_morphology1.52533686
63MP0002396_abnormal_hematopoietic_system1.52472073
64MP0000462_abnormal_digestive_system1.51727779
65MP0002796_impaired_skin_barrier1.45355434
66MP0001533_abnormal_skeleton_physiology1.45335285
67MP0003984_embryonic_growth_retardation1.44372854
68MP0002088_abnormal_embryonic_growth/wei1.42716079
69MP0001663_abnormal_digestive_system1.40995726
70MP0001697_abnormal_embryo_size1.40667643
71MP0005451_abnormal_body_composition1.39163478
72MP0000689_abnormal_spleen_morphology1.38952982
73MP0002722_abnormal_immune_system1.38685045
74MP0002086_abnormal_extraembryonic_tissu1.37228450
75MP0002084_abnormal_developmental_patter1.34774229
76MP0004808_abnormal_hematopoietic_stem1.34395018
77MP0002429_abnormal_blood_cell1.34345937
78MP0010678_abnormal_skin_adnexa1.32733402
79MP0009672_abnormal_birth_weight1.31542678
80MP0005076_abnormal_cell_differentiation1.29358433
81MP0003724_increased_susceptibility_to1.28622652
82MP0004272_abnormal_basement_membrane1.27584636
83MP0002085_abnormal_embryonic_tissue1.27425757
84MP0001293_anophthalmia1.27297394
85MP0003172_abnormal_lysosome_physiology1.26808810
86MP0002080_prenatal_lethality1.25471604
87MP0000569_abnormal_digit_pigmentation1.24264655
88MP0003950_abnormal_plasma_membrane1.24202968
89MP0000579_abnormal_nail_morphology1.22423461
90MP0002009_preneoplasia1.21750063
91MP0003937_abnormal_limbs/digits/tail_de1.21747271
92MP0009278_abnormal_bone_marrow1.21675177
93MP0003453_abnormal_keratinocyte_physiol1.19824317
94MP0000858_altered_metastatic_potential1.18498889
95MP0003315_abnormal_perineum_morphology1.16590220
96MP0000383_abnormal_hair_follicle1.16464667
97MP0004510_myositis1.14300139
98MP0002998_abnormal_bone_remodeling1.13615652
99MP0004782_abnormal_surfactant_physiolog1.12586099
100MP0004264_abnormal_extraembryonic_tissu1.12392867
101MP0004197_abnormal_fetal_growth/weight/1.11866698
102MP0001851_eye_inflammation1.09913688
103MP0003705_abnormal_hypodermis_morpholog1.09702464
104MP0000703_abnormal_thymus_morphology1.08275884
105MP0000477_abnormal_intestine_morphology1.07799517
106MP0005501_abnormal_skin_physiology1.07792235
107MP0004147_increased_porphyrin_level1.07762012
108MP0000762_abnormal_tongue_morphology1.07345770
109MP0000470_abnormal_stomach_morphology1.06154283
110MP0001879_abnormal_lymphatic_vessel1.05171899
111MP0001188_hyperpigmentation1.05016940
112MP0001853_heart_inflammation1.04269468
113MP0005397_hematopoietic_system_phenotyp1.04173653
114MP0001545_abnormal_hematopoietic_system1.04173653
115MP0002060_abnormal_skin_morphology1.04114022
116MP0005381_digestive/alimentary_phenotyp0.99794921
117MP0008469_abnormal_protein_level0.99322713
118MP0002933_joint_inflammation0.96948304
119MP0002254_reproductive_system_inflammat0.94178276
120MP0000627_abnormal_mammary_gland0.93873823
121MP0002092_abnormal_eye_morphology0.91621243
122MP0003567_abnormal_fetal_cardiomyocyte0.90290431
123MP0000313_abnormal_cell_death0.90091298
124MP0001286_abnormal_eye_development0.90031552
125MP0003566_abnormal_cell_adhesion0.89263255
126MP0004084_abnormal_cardiac_muscle0.88822549
127MP0000428_abnormal_craniofacial_morphol0.87301874
128MP0002876_abnormal_thyroid_physiology0.86534958
129MP0000920_abnormal_myelination0.85568207
130MP0001348_abnormal_lacrimal_gland0.84992776
131MP0001666_abnormal_nutrient_absorption0.84504950
132MP0009703_decreased_birth_body0.83555935
133MP0002111_abnormal_tail_morphology0.82804051
134MP0002697_abnormal_eye_size0.82283719
135MP0005621_abnormal_cell_physiology0.81875402
136MP0001849_ear_inflammation0.79160091
137MP0000467_abnormal_esophagus_morphology0.79148521
138MP0000432_abnormal_head_morphology0.77370727
139MP0004185_abnormal_adipocyte_glucose0.77224986
140MP0010030_abnormal_orbit_morphology0.76596370
141MP0001191_abnormal_skin_condition0.76594066
142MP0002098_abnormal_vibrissa_morphology0.76492277
143MP0003183_abnormal_peptide_metabolism0.75411499
144MP0003868_abnormal_feces_composition0.75085551
145MP0002019_abnormal_tumor_incidence0.74619749
146MP0001216_abnormal_epidermal_layer0.74361978
147MP0000377_abnormal_hair_follicle0.74127505
148MP0003943_abnormal_hepatobiliary_system0.72995570
149MP0000604_amyloidosis0.72633933
150MP0003693_abnormal_embryo_hatching0.72299477
151MP0001881_abnormal_mammary_gland0.72282407
152MP0002138_abnormal_hepatobiliary_system0.70054813
153MP0005166_decreased_susceptibility_to0.69372180
154MP0001664_abnormal_digestion0.67327809
155MP0003828_pulmonary_edema0.67046121
156MP0003935_abnormal_craniofacial_develop0.66864473
157MP0003221_abnormal_cardiomyocyte_apopto0.66778259
158MP0008007_abnormal_cellular_replicative0.66218218
159MP0001915_intracranial_hemorrhage0.65566940
160MP0003795_abnormal_bone_structure0.65051133
161MP0005395_other_phenotype0.64292702
162MP0005390_skeleton_phenotype0.63738644
163MP0003091_abnormal_cell_migration0.63071862
164MP0005384_cellular_phenotype0.63067822
165MP0009053_abnormal_anal_canal0.62550234
166MP0005023_abnormal_wound_healing0.62454773
167MP0000678_abnormal_parathyroid_gland0.62354925
168MP0000343_altered_response_to0.60190231
169MP0003045_fibrosis0.59830309
170MP0003075_altered_response_to0.59421278
171MP0005167_abnormal_blood-brain_barrier0.57357507

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)8.80380400
2Abnormality of B cell number (HP:0010975)7.81162645
3Hypoplasia of the thymus (HP:0000778)6.68910997
4Panhypogammaglobulinemia (HP:0003139)6.48312424
5Recurrent abscess formation (HP:0002722)5.69417500
6Recurrent bacterial skin infections (HP:0005406)5.12750374
7Eczematoid dermatitis (HP:0000976)4.95315696
8Hypoproteinemia (HP:0003075)4.80987504
9Abnormality of macrophages (HP:0004311)4.27548526
10Pustule (HP:0200039)3.98582787
11Disinhibition (HP:0000734)3.90318981
12Prostate neoplasm (HP:0100787)3.74569454
13Recurrent fungal infections (HP:0002841)3.65860751
14Increased cerebral lipofuscin (HP:0011813)3.60457626
15Recurrent viral infections (HP:0004429)3.59305420
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.49719942
17Myositis (HP:0100614)3.46686146
18Mediastinal lymphadenopathy (HP:0100721)3.43862897
19Vacuolated lymphocytes (HP:0001922)3.43577240
20T lymphocytopenia (HP:0005403)3.28506169
21Erythroderma (HP:0001019)3.26878271
22Abnormality of T cell number (HP:0011839)3.22789662
23Recurrent skin infections (HP:0001581)3.21613150
24Thrombocytosis (HP:0001894)3.20929594
25Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.19029234
26Autoimmune thrombocytopenia (HP:0001973)3.11615197
27Retrobulbar optic neuritis (HP:0100654)3.08366276
28Optic neuritis (HP:0100653)3.08366276
29Elevated erythrocyte sedimentation rate (HP:0003565)3.04293326
30Abnormal foot bone ossification (HP:0010675)3.02450314
31Orchitis (HP:0100796)3.01764523
32Periodontitis (HP:0000704)3.00641257
33Stomatitis (HP:0010280)2.97628628
34Acute lymphatic leukemia (HP:0006721)2.95718185
35Obstructive lung disease (HP:0006536)2.94215809
36Chronic obstructive pulmonary disease (HP:0006510)2.94215809
37Chronic otitis media (HP:0000389)2.91073488
38Carpal bone hypoplasia (HP:0001498)2.88389829
39Multiple enchondromatosis (HP:0005701)2.86508954
40Agammaglobulinemia (HP:0004432)2.85830536
41Gingivitis (HP:0000230)2.83949598
42Recurrent gram-negative bacterial infections (HP:0005420)2.83915631
43Chromsome breakage (HP:0040012)2.83669908
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82018444
45Agnosia (HP:0010524)2.81919999
46Cellulitis (HP:0100658)2.80174070
47Rhabdomyosarcoma (HP:0002859)2.76846549
48Colon cancer (HP:0003003)2.76180041
49Osteolytic defects of the hand bones (HP:0009699)2.75285251
50Osteolytic defects of the phalanges of the hand (HP:0009771)2.75285251
51Chronic diarrhea (HP:0002028)2.71960596
52Absent frontal sinuses (HP:0002688)2.70268236
53Petechiae (HP:0000967)2.69214108
54Abnormality of chromosome stability (HP:0003220)2.64707590
55Selective tooth agenesis (HP:0001592)2.61921412
56Flat acetabular roof (HP:0003180)2.60807500
57Vasculitis (HP:0002633)2.56462992
58Aplasia/Hypoplasia of the thymus (HP:0010515)2.56071757
59IgM deficiency (HP:0002850)2.53147180
60Biliary tract neoplasm (HP:0100574)2.53081125
61Osteomyelitis (HP:0002754)2.51552502
62Spinal cord lesions (HP:0100561)2.41698013
63Syringomyelia (HP:0003396)2.41698013
64Hematochezia (HP:0002573)2.39619787
65Leukocytosis (HP:0001974)2.39151781
66Abnormality of T cells (HP:0002843)2.35731399
67Embryonal renal neoplasm (HP:0011794)2.35340310
68Interstitial pulmonary disease (HP:0006530)2.34594574
69Chronic mucocutaneous candidiasis (HP:0002728)2.33939106
70Recurrent cutaneous fungal infections (HP:0011370)2.33939106
71Thick nail (HP:0001805)2.33875708
72Recurrent pneumonia (HP:0006532)2.31775260
73Thyroiditis (HP:0100646)2.30693425
74Nephroblastoma (Wilms tumor) (HP:0002667)2.29273527
75Abnormal vertebral ossification (HP:0100569)2.27780836
76Right ventricular cardiomyopathy (HP:0011663)2.27768745
77Abnormality of the thymus (HP:0000777)2.26917181
78Medulloblastoma (HP:0002885)2.26013419
79Meningitis (HP:0001287)2.24065990
80Abnormality of the preputium (HP:0100587)2.23698185
81Abnormality of the prostate (HP:0008775)2.19772161
82Arterial thrombosis (HP:0004420)2.17766101
83Abnormal lung lobation (HP:0002101)2.17592960
84Acute myeloid leukemia (HP:0004808)2.17004157
85Ankyloglossia (HP:0010296)2.16899363
86Severe combined immunodeficiency (HP:0004430)2.16479279
87Micronodular cirrhosis (HP:0001413)2.16034725
88Abnormal tarsal ossification (HP:0008369)2.15668515
89Eosinophilia (HP:0001880)2.12593714
90Deviation of the thumb (HP:0009603)2.12162398
91Missing ribs (HP:0000921)2.10963068
92Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.10661785
93Autoimmune hemolytic anemia (HP:0001890)2.10015433
94Nasal polyposis (HP:0100582)2.09635644
95Abnormal platelet volume (HP:0011876)2.09015377
96Recurrent bronchitis (HP:0002837)2.08491202
97Fatigue (HP:0012378)2.08293285
98Amaurosis fugax (HP:0100576)2.07844058
99Abnormal biliary tract morphology (HP:0012440)2.07671670
100Chest pain (HP:0100749)2.06596432
101Inappropriate behavior (HP:0000719)2.06137277
102Loss of speech (HP:0002371)2.04923962
103Combined immunodeficiency (HP:0005387)2.04362343
104Breast carcinoma (HP:0003002)2.02902839
105Abnormality of eosinophils (HP:0001879)2.01001774
106Premature loss of primary teeth (HP:0006323)2.00046034
107IgA deficiency (HP:0002720)1.99954922
108Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.99919994
109Volvulus (HP:0002580)1.99327472
110Neoplasm of the colon (HP:0100273)1.98587175
111Inflammation of the large intestine (HP:0002037)1.98558798
112Increased nuchal translucency (HP:0010880)1.97802417
113Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.96585698
114Neoplasm of the small intestine (HP:0100833)1.95610101
115Abnormality of cells of the lymphoid lineage (HP:0012140)1.95589905
116Gastrointestinal carcinoma (HP:0002672)1.95089055
117Malignant gastrointestinal tract tumors (HP:0006749)1.95089055
118Hepatosplenomegaly (HP:0001433)1.94953792
119Duodenal stenosis (HP:0100867)1.94588811
120Small intestinal stenosis (HP:0012848)1.94588811
121Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.94365909
122Lymphopenia (HP:0001888)1.94324620
123Sepsis (HP:0100806)1.93354555
124Skin ulcer (HP:0200042)1.93106307
125Cheilitis (HP:0100825)1.92914884
126Abnormality of oral frenula (HP:0000190)1.92344008
127Abnormality of the frontal sinuses (HP:0002687)1.91806613
128Gastrointestinal inflammation (HP:0004386)1.91267421
129Diminished motivation (HP:0000745)1.91147293
130Granulocytopenia (HP:0001913)1.89784798
131IgG deficiency (HP:0004315)1.89619003
132Spastic diplegia (HP:0001264)1.89607149
133Abnormality of T cell physiology (HP:0011840)1.89276903
134Pulmonary infiltrates (HP:0002113)1.88180391
135Proximal placement of thumb (HP:0009623)1.87965760
136Meckel diverticulum (HP:0002245)1.87385782
137Hemoptysis (HP:0002105)1.86937830
138Uterine neoplasm (HP:0010784)1.86866919
139Persistence of primary teeth (HP:0006335)1.86775584
140Myelodysplasia (HP:0002863)1.86305863
141Dysostosis multiplex (HP:0000943)1.86223444
142Basal ganglia calcification (HP:0002135)1.85104675
143Apathy (HP:0000741)1.84369918
144Increased mean platelet volume (HP:0011877)1.83946511
145Hyperactive renin-angiotensin system (HP:0000841)1.82942628
146Myocardial infarction (HP:0001658)1.82251346
147Reticulocytopenia (HP:0001896)1.80757772
148Recurrent lower respiratory tract infections (HP:0002783)1.79737040
149Short middle phalanx of finger (HP:0005819)1.79630194
150Chronic bronchitis (HP:0004469)1.79219588
151Cortical dysplasia (HP:0002539)1.78789656
15211 pairs of ribs (HP:0000878)1.78547644
153Neoplasm of the rectum (HP:0100743)1.78226313
154Metaphyseal dysplasia (HP:0100255)1.76973845
155Ependymoma (HP:0002888)1.76125973
156Mucopolysacchariduria (HP:0008155)1.75113244
157Aplasia/Hypoplasia of the uvula (HP:0010293)1.74443163
158Cellular immunodeficiency (HP:0005374)1.74330125
159Hypoplasia of the pons (HP:0012110)1.73445780
160Abnormality of the pons (HP:0007361)1.72679916
161Birth length less than 3rd percentile (HP:0003561)1.72449311
162Papillary thyroid carcinoma (HP:0002895)1.68877995
163Abnormality of the ileum (HP:0001549)1.67731950
164Ovarian neoplasm (HP:0100615)1.64106321
165Skull defect (HP:0001362)1.63901534
166Abnormality of the distal phalanx of the thumb (HP:0009617)1.63355312
167Aplasia/hypoplasia of the humerus (HP:0006507)1.62830938
168Lymphoma (HP:0002665)1.62479076
169Short humerus (HP:0005792)1.61520909
170Stillbirth (HP:0003826)1.59827736
171Spinal cord compression (HP:0002176)1.58721220
172Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.58338355
173Vertebral hypoplasia (HP:0008417)1.58338355
174Abnormality of the distal phalanges of the toes (HP:0010182)1.57670931
175Curly hair (HP:0002212)1.56304030
176Short middle phalanx of the 5th finger (HP:0004220)1.56209810
177Facial cleft (HP:0002006)1.53801991
178Pili torti (HP:0003777)1.52256219
179Neoplasm of striated muscle (HP:0009728)1.51409926
180Abnormality of the umbilical cord (HP:0010881)1.51089882
181Neoplasm of the pancreas (HP:0002894)1.51083579
182Abnormality of the duodenum (HP:0002246)1.50725552
183Deep philtrum (HP:0002002)1.50651356

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.71625892
2TTK3.36823947
3MAP3K143.14064961
4MET3.13282052
5SRPK13.12849048
6MST42.96844657
7BUB12.71077045
8TAF12.52271303
9NEK12.49022694
10TYK22.43301748
11MAP4K12.41822537
12STK102.35844376
13BLK2.35097517
14TSSK62.21511642
15TXK2.17029865
16BRSK22.16261893
17EPHA22.07495045
18TBK12.07374052
19JAK32.05824675
20IRAK42.05130405
21MKNK22.00417833
22VRK21.91157119
23RIPK41.90214571
24KIT1.88903401
25EPHB11.88315069
26PIK3CA1.83923933
27BMPR1B1.79439584
28PLK31.72527304
29FRK1.71624831
30TNIK1.64197627
31STK38L1.61280275
32JAK11.57358785
33TGFBR11.56768321
34CDK121.56203883
35SMG11.52159895
36IKBKE1.52116587
37IRAK31.51782952
38CSK1.50200751
39IKBKB1.45286773
40ZAP701.44872898
41TAOK31.43446064
42MAP3K101.41719649
43WEE11.39253941
44ITK1.34023523
45EIF2AK11.33689793
46LCK1.33481971
47MATK1.31402534
48LRRK21.30339222
49LATS11.29908309
50ZAK1.28874361
51STK41.27644587
52EEF2K1.25236779
53PAK41.23484338
54TEC1.22141158
55STK31.16808104
56CDK71.16451276
57NEK91.11634881
58CDK81.11549277
59CLK11.10407291
60NME21.09503231
61MAP2K21.08961205
62MST1R1.08781839
63CDC71.08381961
64PLK11.08242250
65PIM21.07345969
66CSF1R1.06163982
67MKNK11.05552986
68CDK61.05098567
69PTK61.01866420
70YES10.99765748
71PIM10.99700697
72HCK0.99644961
73TRPM70.99294223
74MAP3K130.95568099
75TIE10.94276918
76CHUK0.93718778
77SYK0.93498460
78MAP3K80.91604287
79ATR0.90766144
80BTK0.90687918
81FGR0.90008293
82CHEK20.89762913
83MELK0.88994667
84PRKG20.87480523
85EIF2AK20.86650165
86NUAK10.86083593
87ERBB40.84720504
88NEK20.82256991
89FGFR30.81171071
90LYN0.77984225
91RPS6KB20.77168343
92BMX0.76063462
93TTN0.75122236
94VRK10.74896239
95MAPKAPK50.72175339
96TESK10.71695205
97GRK60.71419871
98EIF2AK30.70643857
99RPS6KA40.70479198
100OXSR10.69358626
101LATS20.68643505
102RPS6KA50.68419936
103ALK0.68241893
104SCYL20.67081429
105PDGFRB0.66234210
106ATM0.64725572
107PASK0.64399415
108MAP3K120.63774883
109TGFBR20.62504445
110MARK30.61763513
111PNCK0.61147191
112SIK20.60998493
113BCR0.60349996
114PRKCQ0.59672651
115CHEK10.59442463
116STK390.59244514
117CAMK1G0.59104221
118RIPK10.58695515
119MAPKAPK20.58665352
120JAK20.57416584
121TRIM280.55258571
122TESK20.53649668
123NLK0.52658034
124CDK40.52105370
125EGFR0.51120238
126CDK30.50944449
127BRD40.50257019
128DMPK0.50101952
129PLK40.49229601
130PAK20.48906214
131PIK3CG0.48379510
132BRSK10.47880413
133DYRK30.44457554
134AURKB0.43066878
135ABL10.42888685
136FGFR10.42321915
137LMTK20.42202293
138FYN0.42024419
139MAP2K30.41125244
140BMPR20.41063041
141RPS6KB10.40930852
142ACVR1B0.40456981
143STK240.40358121
144CDK10.39502043
145ERBB30.39181443
146PDK10.38828628
147CAMK1D0.38779588
148FLT30.38237392
149CDK90.37770404
150DAPK10.32159298
151PTK20.31093280
152SIK30.30675016
153CDK20.30465338
154PDK20.27665939
155PRKDC0.24813995
156CSNK1E0.24267420
157CSNK2A10.23852790
158CSNK2A20.23522585

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.82228226
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88738076
3Leishmaniasis_Homo sapiens_hsa051402.67996408
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.46547174
5Cell cycle_Homo sapiens_hsa041102.42955765
6RNA transport_Homo sapiens_hsa030132.36127969
7Homologous recombination_Homo sapiens_hsa034402.22921466
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.15318789
9Base excision repair_Homo sapiens_hsa034102.14295831
10Proteasome_Homo sapiens_hsa030502.12802414
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.04217640
12Allograft rejection_Homo sapiens_hsa053302.03738304
13Osteoclast differentiation_Homo sapiens_hsa043802.02359621
14* Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.99094013
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.97946084
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.92049672
17Measles_Homo sapiens_hsa051621.89524557
18Graft-versus-host disease_Homo sapiens_hsa053321.81343646
19Antigen processing and presentation_Homo sapiens_hsa046121.80894490
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.80003591
21Nucleotide excision repair_Homo sapiens_hsa034201.77920505
22Fanconi anemia pathway_Homo sapiens_hsa034601.72485975
23Legionellosis_Homo sapiens_hsa051341.70878021
24Primary immunodeficiency_Homo sapiens_hsa053401.67887603
25Influenza A_Homo sapiens_hsa051641.64643537
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64049822
27Toxoplasmosis_Homo sapiens_hsa051451.61407116
28Tuberculosis_Homo sapiens_hsa051521.59128072
29B cell receptor signaling pathway_Homo sapiens_hsa046621.58906762
30Thyroid cancer_Homo sapiens_hsa052161.54598157
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53584525
32Herpes simplex infection_Homo sapiens_hsa051681.51279646
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51131958
34Vitamin digestion and absorption_Homo sapiens_hsa049771.49315456
35Pertussis_Homo sapiens_hsa051331.48488364
36TNF signaling pathway_Homo sapiens_hsa046681.48119554
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.47210208
38Hematopoietic cell lineage_Homo sapiens_hsa046401.45861823
39Salmonella infection_Homo sapiens_hsa051321.42243302
40mRNA surveillance pathway_Homo sapiens_hsa030151.40531207
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.38139579
42Shigellosis_Homo sapiens_hsa051311.37918994
43Mineral absorption_Homo sapiens_hsa049781.37398021
44Apoptosis_Homo sapiens_hsa042101.35827531
45Selenocompound metabolism_Homo sapiens_hsa004501.33629602
46Viral myocarditis_Homo sapiens_hsa054161.32687620
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.31059929
48Malaria_Homo sapiens_hsa051441.29843048
49Basal transcription factors_Homo sapiens_hsa030221.28608076
50Caffeine metabolism_Homo sapiens_hsa002321.27165906
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27012526
52Chemokine signaling pathway_Homo sapiens_hsa040621.26365495
53Lysosome_Homo sapiens_hsa041421.25658208
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24953484
55Glutathione metabolism_Homo sapiens_hsa004801.24317341
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.24247610
57Jak-STAT signaling pathway_Homo sapiens_hsa046301.24218361
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23415416
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23005812
60Pyrimidine metabolism_Homo sapiens_hsa002401.21996059
61Phototransduction_Homo sapiens_hsa047441.21941667
62RNA degradation_Homo sapiens_hsa030181.21312275
63T cell receptor signaling pathway_Homo sapiens_hsa046601.20928827
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19923792
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19770945
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19602229
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16255352
68Pancreatic secretion_Homo sapiens_hsa049721.15845669
69Hepatitis B_Homo sapiens_hsa051611.14412081
70Asthma_Homo sapiens_hsa053101.14184683
71Rheumatoid arthritis_Homo sapiens_hsa053231.13762435
72Autoimmune thyroid disease_Homo sapiens_hsa053201.10966686
73Phagosome_Homo sapiens_hsa041451.10178484
74Biosynthesis of amino acids_Homo sapiens_hsa012301.09083594
75N-Glycan biosynthesis_Homo sapiens_hsa005101.08373737
76Viral carcinogenesis_Homo sapiens_hsa052031.05670731
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03183829
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02223062
79RNA polymerase_Homo sapiens_hsa030201.01033798
80Hepatitis C_Homo sapiens_hsa051600.99212067
81Type I diabetes mellitus_Homo sapiens_hsa049400.98557243
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95820400
83Platelet activation_Homo sapiens_hsa046110.92552019
84One carbon pool by folate_Homo sapiens_hsa006700.90906299
85Pyruvate metabolism_Homo sapiens_hsa006200.89731692
86Tight junction_Homo sapiens_hsa045300.88962299
87Chronic myeloid leukemia_Homo sapiens_hsa052200.88285465
88Systemic lupus erythematosus_Homo sapiens_hsa053220.88065306
89Vitamin B6 metabolism_Homo sapiens_hsa007500.86885184
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86582360
91Ribosome_Homo sapiens_hsa030100.86041235
92Propanoate metabolism_Homo sapiens_hsa006400.86017919
93Galactose metabolism_Homo sapiens_hsa000520.84555229
94Sulfur metabolism_Homo sapiens_hsa009200.84357705
95Purine metabolism_Homo sapiens_hsa002300.84184090
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83511446
97Renin-angiotensin system_Homo sapiens_hsa046140.83490311
98Other glycan degradation_Homo sapiens_hsa005110.83088278
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82959535
100Small cell lung cancer_Homo sapiens_hsa052220.82293018
101Sphingolipid metabolism_Homo sapiens_hsa006000.79686429
102Staphylococcus aureus infection_Homo sapiens_hsa051500.79571783
103Acute myeloid leukemia_Homo sapiens_hsa052210.79418167
104TGF-beta signaling pathway_Homo sapiens_hsa043500.78857812
105Pancreatic cancer_Homo sapiens_hsa052120.77773292
106Carbon metabolism_Homo sapiens_hsa012000.76441810
107Protein digestion and absorption_Homo sapiens_hsa049740.76331346
108Adherens junction_Homo sapiens_hsa045200.74071504
109Ether lipid metabolism_Homo sapiens_hsa005650.73533379
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73404201
111African trypanosomiasis_Homo sapiens_hsa051430.73221142
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71575632
113Epstein-Barr virus infection_Homo sapiens_hsa051690.69616609
114Fat digestion and absorption_Homo sapiens_hsa049750.65863764
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64695249
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.63781747
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62791944
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62601133
119MicroRNAs in cancer_Homo sapiens_hsa052060.61667306
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.60677628
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60519539
122Starch and sucrose metabolism_Homo sapiens_hsa005000.60285141
123HTLV-I infection_Homo sapiens_hsa051660.60187982
124Hippo signaling pathway_Homo sapiens_hsa043900.59986388
125Fatty acid biosynthesis_Homo sapiens_hsa000610.58177459
126Colorectal cancer_Homo sapiens_hsa052100.57992417
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.57562749
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56031332
129p53 signaling pathway_Homo sapiens_hsa041150.55896111
130Protein export_Homo sapiens_hsa030600.55250793
131Proteoglycans in cancer_Homo sapiens_hsa052050.54419444
132HIF-1 signaling pathway_Homo sapiens_hsa040660.54394149
133Oocyte meiosis_Homo sapiens_hsa041140.53116953
134DNA replication_Homo sapiens_hsa030300.52799055
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51506763
136Inositol phosphate metabolism_Homo sapiens_hsa005620.50905483
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50799985
138Amoebiasis_Homo sapiens_hsa051460.48920665
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47900978
140Non-homologous end-joining_Homo sapiens_hsa034500.47704306
141Fructose and mannose metabolism_Homo sapiens_hsa000510.47381930
142Fatty acid elongation_Homo sapiens_hsa000620.45883104
143Pentose phosphate pathway_Homo sapiens_hsa000300.45737176
144Bladder cancer_Homo sapiens_hsa052190.44516981
145Basal cell carcinoma_Homo sapiens_hsa052170.44405508
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44329497
147Steroid biosynthesis_Homo sapiens_hsa001000.44098664
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42860448
149Fatty acid metabolism_Homo sapiens_hsa012120.42855910
150Prostate cancer_Homo sapiens_hsa052150.42498863
151Notch signaling pathway_Homo sapiens_hsa043300.41913138
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41664939
153Neurotrophin signaling pathway_Homo sapiens_hsa047220.39524513
154Spliceosome_Homo sapiens_hsa030400.37590726
155FoxO signaling pathway_Homo sapiens_hsa040680.35701919
156Lysine degradation_Homo sapiens_hsa003100.34328441
157Pathways in cancer_Homo sapiens_hsa052000.32607724
158Wnt signaling pathway_Homo sapiens_hsa043100.32603722
159Hedgehog signaling pathway_Homo sapiens_hsa043400.29957400
160Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29629122
161Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28482481
162Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28005964
163Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27911391
164Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27728089
165Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26856659

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