GALNTL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1facial nerve structural organization (GO:0021612)8.50361316
2proteasome assembly (GO:0043248)7.44126487
3cranial nerve structural organization (GO:0021604)6.41222519
4protein localization to synapse (GO:0035418)5.78880512
5lymphoid progenitor cell differentiation (GO:0002320)5.64245700
6short-term memory (GO:0007614)5.56460326
7ribosomal small subunit assembly (GO:0000028)5.15621093
8respiratory chain complex IV assembly (GO:0008535)4.86969623
9viral transcription (GO:0019083)4.83292596
10postsynaptic membrane organization (GO:0001941)4.76749525
11negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.75281523
12pyrimidine nucleobase catabolic process (GO:0006208)4.69606162
13glutamate receptor signaling pathway (GO:0007215)4.63705858
14synaptic vesicle exocytosis (GO:0016079)4.54780544
15translational termination (GO:0006415)4.54018390
16negative regulation of leukocyte chemotaxis (GO:0002689)4.51014591
17response to folic acid (GO:0051593)4.50573800
18melanin biosynthetic process (GO:0042438)4.44336276
19G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.44018521
20ribosomal small subunit biogenesis (GO:0042274)4.39676029
21positive regulation of mitochondrial fission (GO:0090141)4.37944900
22establishment of mitochondrion localization (GO:0051654)4.28223208
23DNA deamination (GO:0045006)4.27765542
24presynaptic membrane assembly (GO:0097105)4.23728338
25cartilage morphogenesis (GO:0060536)4.19376083
26neurotransmitter-gated ion channel clustering (GO:0072578)4.18818661
27synaptic vesicle maturation (GO:0016188)4.17791067
28dopamine biosynthetic process (GO:0042416)4.17462290
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.15660071
30toxin transport (GO:1901998)4.13566320
31regulation of short-term neuronal synaptic plasticity (GO:0048172)4.13172091
32vocalization behavior (GO:0071625)4.12972726
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.09212069
34cotranslational protein targeting to membrane (GO:0006613)4.08136310
35protein targeting to ER (GO:0045047)4.02234869
36platelet dense granule organization (GO:0060155)4.01335580
37synaptic transmission, glutamatergic (GO:0035249)3.99749829
38gamma-aminobutyric acid transport (GO:0015812)3.99090506
39melanin metabolic process (GO:0006582)3.98734146
40neurofilament cytoskeleton organization (GO:0060052)3.97620106
41protein localization to endoplasmic reticulum (GO:0070972)3.91654846
42cytochrome complex assembly (GO:0017004)3.89362653
43L-fucose catabolic process (GO:0042355)3.86359520
44fucose catabolic process (GO:0019317)3.86359520
45L-fucose metabolic process (GO:0042354)3.86359520
46establishment of protein localization to endoplasmic reticulum (GO:0072599)3.86157415
47mature B cell differentiation (GO:0002335)3.85133871
48neuron recognition (GO:0008038)3.81891783
49nucleobase catabolic process (GO:0046113)3.80706399
50behavioral response to nicotine (GO:0035095)3.79481913
51exploration behavior (GO:0035640)3.78602092
52auditory behavior (GO:0031223)3.76814505
53neuron-neuron synaptic transmission (GO:0007270)3.67592786
54thalamus development (GO:0021794)3.67391009
55establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.65865702
56mitochondrion transport along microtubule (GO:0047497)3.65865702
57translational elongation (GO:0006414)3.63979419
58secondary metabolite biosynthetic process (GO:0044550)3.63827405
59GPI anchor biosynthetic process (GO:0006506)3.63638403
60synapse assembly (GO:0007416)3.63387894
61response to interferon-beta (GO:0035456)3.58178513
62presynaptic membrane organization (GO:0097090)3.54755094
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.54451509
64regulation of non-canonical Wnt signaling pathway (GO:2000050)3.54385048
65membrane depolarization during action potential (GO:0086010)3.50761624
66phenol-containing compound biosynthetic process (GO:0046189)3.50126261
67mannosylation (GO:0097502)3.48337702
68anatomical structure arrangement (GO:0048532)3.48318004
69startle response (GO:0001964)3.47971798
70axonal fasciculation (GO:0007413)3.46022327
71behavioral response to cocaine (GO:0048148)3.45668791
72cellular protein complex disassembly (GO:0043624)3.42889502
73layer formation in cerebral cortex (GO:0021819)3.42455277
74genitalia morphogenesis (GO:0035112)3.36829089
75synaptic vesicle endocytosis (GO:0048488)3.35900288
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.33518036
77negative regulation of microtubule polymerization (GO:0031115)3.32464339
78dendritic spine organization (GO:0097061)3.32380300
79viral life cycle (GO:0019058)3.30910594
80regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27564467
81transmission of nerve impulse (GO:0019226)3.26226449
82response to interferon-alpha (GO:0035455)3.24843036
83synaptic transmission, cholinergic (GO:0007271)3.24430996
84ribosomal large subunit biogenesis (GO:0042273)3.23553824
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.21516987
86maturation of SSU-rRNA (GO:0030490)3.20148324
87negative regulation of erythrocyte differentiation (GO:0045647)3.19720076
88regulation of excitatory postsynaptic membrane potential (GO:0060079)3.18722981
89DNA damage response, detection of DNA damage (GO:0042769)3.17746639
90regulation of dopamine secretion (GO:0014059)3.17436943
91regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.16935132
92mechanosensory behavior (GO:0007638)3.15977899
93positive regulation of dendritic spine morphogenesis (GO:0061003)3.15523006
94regulation of mitochondrial fission (GO:0090140)3.13990042
95positive regulation of dendritic spine development (GO:0060999)3.11230374
96response to pheromone (GO:0019236)3.09854836
97neurotransmitter secretion (GO:0007269)3.09642955
98synaptic transmission, dopaminergic (GO:0001963)3.09579092
99response to histamine (GO:0034776)3.09078249
100regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.08812842
101GTP biosynthetic process (GO:0006183)3.08650756
102righting reflex (GO:0060013)3.08515981
103glutamate secretion (GO:0014047)3.07367940
104regulation of synapse structural plasticity (GO:0051823)3.06719592
105nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.04848734
106neuronal action potential propagation (GO:0019227)3.03444093
107positive regulation of cellular amine metabolic process (GO:0033240)3.01973914
108GPI anchor metabolic process (GO:0006505)3.01284585
109retinal ganglion cell axon guidance (GO:0031290)3.01219902
110negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01142228
111regulation of synaptic transmission, glutamatergic (GO:0051966)2.98453452
112gamma-aminobutyric acid signaling pathway (GO:0007214)2.97748313
113mitochondrial fission (GO:0000266)2.97259208
114protein localization to cilium (GO:0061512)2.96964413
115dopamine transport (GO:0015872)2.96577383
116regulation of pigment cell differentiation (GO:0050932)2.95432435
117membrane depolarization (GO:0051899)2.95416067
118mitochondrial respiratory chain complex I assembly (GO:0032981)2.95018198
119NADH dehydrogenase complex assembly (GO:0010257)2.95018198
120mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95018198
121regulation of postsynaptic membrane potential (GO:0060078)2.94766875
122regulation of glutamate receptor signaling pathway (GO:1900449)2.93816972
123protein complex biogenesis (GO:0070271)2.93712668
124negative regulation of gluconeogenesis (GO:0045721)2.93532992
125microtubule severing (GO:0051013)2.91920880
126positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.91575678
127regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.91457010
128neuronal action potential (GO:0019228)2.91116973
129mature B cell differentiation involved in immune response (GO:0002313)2.90718372
130atrial cardiac muscle cell action potential (GO:0086014)2.90132281
131positive regulation of synapse maturation (GO:0090129)2.89309737
132behavioral response to ethanol (GO:0048149)2.88599976
133cell migration in hindbrain (GO:0021535)2.88537522
134response to cocaine (GO:0042220)2.87727067
135C-terminal protein lipidation (GO:0006501)2.86352725
136response to auditory stimulus (GO:0010996)2.83862994
137protein complex disassembly (GO:0043241)2.83195701
138regulation of synapse assembly (GO:0051963)2.82862605
139regulation of neurotransmitter levels (GO:0001505)2.81643765
140negative regulation of viral genome replication (GO:0045071)2.81465986
141neurotransmitter transport (GO:0006836)2.80859584
142pattern specification involved in kidney development (GO:0061004)2.80232725
143positive regulation of neurotransmitter secretion (GO:0001956)2.79999397
144positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.79101904
145prepulse inhibition (GO:0060134)2.78662425
146primitive streak formation (GO:0090009)2.78407908
147synaptic vesicle transport (GO:0048489)2.77435764
148establishment of synaptic vesicle localization (GO:0097480)2.77435764
149fucosylation (GO:0036065)2.76456334
150protein polyglutamylation (GO:0018095)2.76325440
151neuron cell-cell adhesion (GO:0007158)2.75269346
152retinal rod cell development (GO:0046548)2.74934317
153negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74794264
154catechol-containing compound biosynthetic process (GO:0009713)2.74199538
155catecholamine biosynthetic process (GO:0042423)2.74199538
156mesonephros development (GO:0001823)2.73186415
157daunorubicin metabolic process (GO:0044597)2.73104012
158polyketide metabolic process (GO:0030638)2.73104012
159doxorubicin metabolic process (GO:0044598)2.73104012
160tRNA methylation (GO:0030488)2.72881150
161proline transport (GO:0015824)2.72759463
162thyroid gland development (GO:0030878)2.72235328
163defense response to protozoan (GO:0042832)2.71724616
164preassembly of GPI anchor in ER membrane (GO:0016254)2.71473630
165epithelial cell differentiation involved in kidney development (GO:0035850)2.69276049
166definitive hemopoiesis (GO:0060216)2.69121914
167macromolecular complex disassembly (GO:0032984)2.68916713
168neurotransmitter biosynthetic process (GO:0042136)2.68822764
169translational initiation (GO:0006413)2.68408460
170cranial nerve morphogenesis (GO:0021602)2.68121944
171negative regulation of membrane potential (GO:0045837)2.68013145
172neurotransmitter metabolic process (GO:0042133)2.65496047
173dendritic spine morphogenesis (GO:0060997)2.65161635
174calcium ion-dependent exocytosis (GO:0017156)2.65100730
175acrosome reaction (GO:0007340)2.65067765
176positive regulation of uterine smooth muscle contraction (GO:0070474)2.64668707
177response to amphetamine (GO:0001975)2.64621859
178response to muscle activity (GO:0014850)2.64218443
179mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.62003835
180positive regulation of synapse assembly (GO:0051965)2.60448407
181positive regulation of membrane potential (GO:0045838)2.60379063
182axon ensheathment in central nervous system (GO:0032291)2.59320505
183central nervous system myelination (GO:0022010)2.59320505
184activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.58809625
185regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.57267998
186omega-hydroxylase P450 pathway (GO:0097267)2.56931836
187protein targeting to membrane (GO:0006612)2.53350492
188mitochondrial respiratory chain complex assembly (GO:0033108)2.52200364
189ionotropic glutamate receptor signaling pathway (GO:0035235)2.49126653

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.39462548
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.39748146
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.47906693
4GBX2_23144817_ChIP-Seq_PC3_Human3.42671312
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.37277543
6SCL_19346495_ChIP-Seq_HPC-7_Human2.96947421
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.84683482
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.63195313
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.57784291
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53432539
11IGF1R_20145208_ChIP-Seq_DFB_Human2.43669042
12REST_21632747_ChIP-Seq_MESCs_Mouse2.43169902
13LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.32964973
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30713870
15TAF15_26573619_Chip-Seq_HEK293_Human2.22755918
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15360256
17IRF1_19129219_ChIP-ChIP_H3396_Human2.10723785
18GATA1_22025678_ChIP-Seq_K562_Human2.09670110
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06068996
20REST_18959480_ChIP-ChIP_MESCs_Mouse1.98122592
21ZNF274_21170338_ChIP-Seq_K562_Hela1.97968784
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.93437260
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91777008
24* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89504797
25VDR_22108803_ChIP-Seq_LS180_Human1.88240971
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80484591
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.79225840
28* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78374559
29* SMAD4_21799915_ChIP-Seq_A2780_Human1.76688734
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75622541
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.75238072
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.74289138
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73119171
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72953193
35EWS_26573619_Chip-Seq_HEK293_Human1.72911289
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69369711
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69352000
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66921666
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65652903
40AR_21572438_ChIP-Seq_LNCaP_Human1.65479511
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64951938
42DROSHA_22980978_ChIP-Seq_HELA_Human1.64706810
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64366130
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.64169901
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64169901
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63828030
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63803420
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62020442
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61239931
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57473233
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56702153
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56660447
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.56379652
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55821071
55* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54898874
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53096486
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.53073434
58AR_25329375_ChIP-Seq_VCAP_Human1.52966754
59* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50053889
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49697153
61* STAT3_23295773_ChIP-Seq_U87_Human1.49089267
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.48924068
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47584538
64EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47194015
65RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47194015
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45869795
67* TCF4_23295773_ChIP-Seq_U87_Human1.45448405
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43360535
69CBP_20019798_ChIP-Seq_JUKART_Human1.43360535
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43250096
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42725074
72RNF2_27304074_Chip-Seq_NSC_Mouse1.41174973
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41170718
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36603686
75P53_22387025_ChIP-Seq_ESCs_Mouse1.35312347
76* SMAD3_21741376_ChIP-Seq_EPCs_Human1.34068288
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33635295
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33257747
79P300_18555785_Chip-Seq_ESCs_Mouse1.32296149
80* RUNX2_22187159_ChIP-Seq_PCA_Human1.31696472
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31471904
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.29519528
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29373877
84RNF2_27304074_Chip-Seq_ESCs_Mouse1.29332280
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29250596
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.29001352
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27965743
88SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27844315
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.27600394
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27281033
91RUNX1_27457419_Chip-Seq_LIVER_Mouse1.26448293
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.26325574
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23889648
94NMYC_18555785_Chip-Seq_ESCs_Mouse1.23134719
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22524801
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21866768
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21464754
98POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20846758
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.20663741
100MYC_18940864_ChIP-ChIP_HL60_Human1.19445645
101JUN_21703547_ChIP-Seq_K562_Human1.19432611
102FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18008690
103STAT3_18555785_Chip-Seq_ESCs_Mouse1.17242355
104BCAT_22108803_ChIP-Seq_LS180_Human1.17124450
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16329496
106E2F1_18555785_Chip-Seq_ESCs_Mouse1.15822465
107HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15635300
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14222939
109CMYC_18555785_Chip-Seq_ESCs_Mouse1.14168636
110GATA1_26923725_Chip-Seq_HPCs_Mouse1.13578805
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13448719
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12601114
113* P300_19829295_ChIP-Seq_ESCs_Human1.11163982
114MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11049912
115TP53_22573176_ChIP-Seq_HFKS_Human1.10758722
116ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09424724
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.07925052
118* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07094118
119ER_23166858_ChIP-Seq_MCF-7_Human1.07052790
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.06670033
121SOX2_18555785_Chip-Seq_ESCs_Mouse1.06632333
122RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06616349
123RARB_27405468_Chip-Seq_BRAIN_Mouse1.06209648
124ZFX_18555785_Chip-Seq_ESCs_Mouse1.06141423
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.06093309
126MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05992176
127E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04957550
128OCT4_18555785_Chip-Seq_ESCs_Mouse1.04695889
129SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04359600
130RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03995325
131SRF_21415370_ChIP-Seq_HL-1_Mouse1.03907141
132CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03397261
133IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02315638
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02113065
135PU1_27457419_Chip-Seq_LIVER_Mouse1.01804686
136* TCF4_22108803_ChIP-Seq_LS180_Human1.01599065
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01383343
138* FUS_26573619_Chip-Seq_HEK293_Human1.01214556
139KLF4_18555785_Chip-Seq_ESCs_Mouse1.01210346
140PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01061105
141KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00354541
142RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99474127
143SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99293714
144SOX2_19829295_ChIP-Seq_ESCs_Human0.98971679
145NANOG_19829295_ChIP-Seq_ESCs_Human0.98971679
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98808592
147KDM2B_26808549_Chip-Seq_REH_Human0.98491543
148MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98421755
149LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98139018
150CRX_20693478_ChIP-Seq_RETINA_Mouse0.98126063
151CTCF_18555785_Chip-Seq_ESCs_Mouse0.96995763
152PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96855420
153TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96595780
154* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95492980
155SOX9_26525672_Chip-Seq_HEART_Mouse0.94974375
156* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93339704

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy6.25013885
2MP0001188_hyperpigmentation4.63474340
3MP0009379_abnormal_foot_pigmentation4.33622926
4MP0003136_yellow_coat_color4.26915818
5MP0006292_abnormal_olfactory_placode3.60295815
6MP0005409_darkened_coat_color3.55996862
7MP0003880_abnormal_central_pattern3.18894900
8MP0004145_abnormal_muscle_electrophysio3.11402435
9MP0004270_analgesia2.85812731
10MP0004381_abnormal_hair_follicle2.85558981
11MP0004147_increased_porphyrin_level2.76616760
12MP0004142_abnormal_muscle_tone2.75547987
13MP0000569_abnormal_digit_pigmentation2.67541849
14MP0005174_abnormal_tail_pigmentation2.62899715
15MP0002735_abnormal_chemical_nociception2.56282561
16MP0005075_abnormal_melanosome_morpholog2.56135967
17MP0003724_increased_susceptibility_to2.39966887
18MP0000749_muscle_degeneration2.36488667
19MP0001986_abnormal_taste_sensitivity2.27074081
20MP0002063_abnormal_learning/memory/cond2.17238677
21MP0000372_irregular_coat_pigmentation2.08053366
22MP0001486_abnormal_startle_reflex2.06859220
23MP0002095_abnormal_skin_pigmentation2.00807040
24MP0002009_preneoplasia1.90675997
25MP0001984_abnormal_olfaction1.85769915
26MP0002396_abnormal_hematopoietic_system1.84529144
27MP0000778_abnormal_nervous_system1.81373683
28MP0000015_abnormal_ear_pigmentation1.80014726
29MP0002909_abnormal_adrenal_gland1.64612605
30MP0008877_abnormal_DNA_methylation1.61671109
31MP0003122_maternal_imprinting1.59627471
32MP0002067_abnormal_sensory_capabilities1.55735570
33MP0009697_abnormal_copulation1.54679277
34MP0001970_abnormal_pain_threshold1.52625508
35MP0009046_muscle_twitch1.52051630
36MP0005253_abnormal_eye_physiology1.51208202
37MP0005645_abnormal_hypothalamus_physiol1.50040810
38MP0002177_abnormal_outer_ear1.49675725
39MP0003635_abnormal_synaptic_transmissio1.42870571
40MP0004811_abnormal_neuron_physiology1.41403681
41MP0003121_genomic_imprinting1.40871072
42MP0002272_abnormal_nervous_system1.40688721
43MP0005671_abnormal_response_to1.39017460
44MP0004742_abnormal_vestibular_system1.38571328
45MP0001440_abnormal_grooming_behavior1.36843569
46MP0009745_abnormal_behavioral_response1.35254751
47MP0000490_abnormal_crypts_of1.33837648
48MP0003879_abnormal_hair_cell1.33465969
49MP0010386_abnormal_urinary_bladder1.33413250
50MP0002734_abnormal_mechanical_nocicepti1.32431456
51MP0000681_abnormal_thyroid_gland1.31870291
52MP0002876_abnormal_thyroid_physiology1.29739523
53MP0002882_abnormal_neuron_morphology1.29144429
54MP0008569_lethality_at_weaning1.28981050
55MP0005646_abnormal_pituitary_gland1.27196648
56MP0000685_abnormal_immune_system1.25493178
57MP0002064_seizures1.22780130
58MP0009785_altered_susceptibility_to1.22273867
59MP0001968_abnormal_touch/_nociception1.20378180
60MP0003938_abnormal_ear_development1.20360018
61MP0004808_abnormal_hematopoietic_stem1.19560655
62MP0002090_abnormal_vision1.16619504
63MP0001905_abnormal_dopamine_level1.13691171
64MP0003787_abnormal_imprinting1.13529841
65MP0003866_abnormal_defecation1.11432657
66MP0008995_early_reproductive_senescence1.10375447
67MP0000049_abnormal_middle_ear1.10339668
68MP0000631_abnormal_neuroendocrine_gland1.09608174
69MP0003303_peritoneal_inflammation1.09519339
70MP0002249_abnormal_larynx_morphology1.05138884
71MP0001664_abnormal_digestion1.04109308
72MP0001963_abnormal_hearing_physiology1.02655470
73MP0004859_abnormal_synaptic_plasticity1.02447727
74MP0003656_abnormal_erythrocyte_physiolo1.02239750
75MP0001501_abnormal_sleep_pattern1.00326827
76MP0002148_abnormal_hypersensitivity_rea1.00242058
77MP0008260_abnormal_autophagy0.99951135
78MP0003890_abnormal_embryonic-extraembry0.99339804
79MP0001835_abnormal_antigen_presentation0.98155008
80MP0005248_abnormal_Harderian_gland0.96648202
81MP0003646_muscle_fatigue0.94996570
82MP0004885_abnormal_endolymph0.94606338
83MP0006276_abnormal_autonomic_nervous0.93813869
84MP0005394_taste/olfaction_phenotype0.93507248
85MP0005499_abnormal_olfactory_system0.93507248
86MP0002102_abnormal_ear_morphology0.92788247
87MP0005025_abnormal_response_to0.92606673
88MP0002152_abnormal_brain_morphology0.92557985
89MP0001502_abnormal_circadian_rhythm0.92061453
90MP0003329_amyloid_beta_deposits0.92034137
91MP0002733_abnormal_thermal_nociception0.91657546
92MP0005423_abnormal_somatic_nervous0.91510247
93MP0002751_abnormal_autonomic_nervous0.88581920
94MP0002572_abnormal_emotion/affect_behav0.87206003
95MP0005386_behavior/neurological_phenoty0.86821994
96MP0004924_abnormal_behavior0.86821994
97MP0001529_abnormal_vocalization0.86513277
98MP0002184_abnormal_innervation0.84986805
99MP0001663_abnormal_digestive_system0.84557841
100MP0003828_pulmonary_edema0.83954601
101MP0002557_abnormal_social/conspecific_i0.83503533
102MP0000026_abnormal_inner_ear0.82641757
103MP0005171_absent_coat_pigmentation0.82343655
104MP0006072_abnormal_retinal_apoptosis0.81268161
105MP0002752_abnormal_somatic_nervous0.79830510
106MP0001800_abnormal_humoral_immune0.79120655
107MP0001324_abnormal_eye_pigmentation0.77968138
108MP0003698_abnormal_male_reproductive0.76869049
109MP0005408_hypopigmentation0.76800392
110MP0002277_abnormal_respiratory_mucosa0.76005300
111MP0004085_abnormal_heartbeat0.75876650
112MP0000465_gastrointestinal_hemorrhage0.75573029
113MP0000371_diluted_coat_color0.74353906
114MP0002938_white_spotting0.72976557
115MP0002166_altered_tumor_susceptibility0.72617143
116MP0003631_nervous_system_phenotype0.72449798
117MP0003632_abnormal_nervous_system0.72307256
118MP0002638_abnormal_pupillary_reflex0.71748229
119MP0002723_abnormal_immune_serum0.70480909
120MP0004215_abnormal_myocardial_fiber0.69888923
121MP0000955_abnormal_spinal_cord0.69836171
122MP0001485_abnormal_pinna_reflex0.68140952
123MP0000579_abnormal_nail_morphology0.68021394
124MP0000013_abnormal_adipose_tissue0.66794904
125MP0002736_abnormal_nociception_after0.66238408
126MP0002069_abnormal_eating/drinking_beha0.65457435
127MP0005165_increased_susceptibility_to0.65443131
128MP0005195_abnormal_posterior_eye0.64883391
129MP0008872_abnormal_physiological_respon0.63879890
130MP0005551_abnormal_eye_electrophysiolog0.63607615
131MP0005391_vision/eye_phenotype0.63355978
132MP0008874_decreased_physiological_sensi0.63352868
133MP0002229_neurodegeneration0.63172874
134MP0005000_abnormal_immune_tolerance0.62678735
135MP0003868_abnormal_feces_composition0.62579586
136MP0003633_abnormal_nervous_system0.62548182
137MP0002210_abnormal_sex_determination0.62201290
138MP0003137_abnormal_impulse_conducting0.61580084
139MP0008058_abnormal_DNA_repair0.61107659
140MP0005187_abnormal_penis_morphology0.60417399
141MP0001661_extended_life_span0.59251826
142MP0002066_abnormal_motor_capabilities/c0.58776003
143MP0005623_abnormal_meninges_morphology0.58498779
144MP0002420_abnormal_adaptive_immunity0.57782258
145MP0003861_abnormal_nervous_system0.56725915
146MP0005464_abnormal_platelet_physiology0.56559233
147MP0006036_abnormal_mitochondrial_physio0.56542396
148MP0001819_abnormal_immune_cell0.56061574
149MP0002419_abnormal_innate_immunity0.55828784
150MP0003315_abnormal_perineum_morphology0.55679056
151MP0002653_abnormal_ependyma_morphology0.55315617

Predicted human phenotypes

RankGene SetZ-score
1Nonprogressive disorder (HP:0003680)8.89285535
2Limb dystonia (HP:0002451)6.72993159
3Type 2 muscle fiber atrophy (HP:0003554)5.58530177
4Abnormality of secondary sexual hair (HP:0009888)5.19831856
5Abnormality of the axillary hair (HP:0100134)5.19831856
6Muscle fiber atrophy (HP:0100295)5.04492168
7Myokymia (HP:0002411)4.99525131
8Congenital stationary night blindness (HP:0007642)4.88880269
93-Methylglutaconic aciduria (HP:0003535)4.71436267
10Progressive inability to walk (HP:0002505)4.23800826
11Microvesicular hepatic steatosis (HP:0001414)4.06808616
12Type I transferrin isoform profile (HP:0003642)4.01066459
13Progressive cerebellar ataxia (HP:0002073)3.89952077
14Action tremor (HP:0002345)3.88734144
15Focal seizures (HP:0007359)3.72690014
16Febrile seizures (HP:0002373)3.68138936
17Hepatocellular necrosis (HP:0001404)3.53409840
18Atonic seizures (HP:0010819)3.47624006
19Polyphagia (HP:0002591)3.46810965
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.37842614
21Reduced antithrombin III activity (HP:0001976)3.36921720
22Morphological abnormality of the pyramidal tract (HP:0002062)3.36173086
23Hypothermia (HP:0002045)3.35065310
24Abnormality of cells of the erythroid lineage (HP:0012130)3.33707509
25Epileptic encephalopathy (HP:0200134)3.31788415
26Blue irides (HP:0000635)3.30784409
27Focal motor seizures (HP:0011153)3.29583978
28Abnormal number of erythroid precursors (HP:0012131)3.26702588
29Increased hepatocellular lipid droplets (HP:0006565)3.23939695
30Gaze-evoked nystagmus (HP:0000640)3.21627010
31Dry hair (HP:0011359)3.21121516
32Amblyopia (HP:0000646)3.19107621
33Weak cry (HP:0001612)3.16202810
34Renal Fanconi syndrome (HP:0001994)3.11741538
35Thyroid-stimulating hormone excess (HP:0002925)3.07886686
36Abnormality of the corticospinal tract (HP:0002492)3.06472940
37Peripheral hypomyelination (HP:0007182)3.05217052
38Hyperventilation (HP:0002883)3.04319102
39Fatigable weakness (HP:0003473)3.03873628
40Abnormality of the neuromuscular junction (HP:0003398)3.03873628
41Akinesia (HP:0002304)2.98149350
42Mitochondrial inheritance (HP:0001427)2.95428043
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.93100881
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.93100881
45Abnormality of the fovea (HP:0000493)2.92690054
46Aplasia/Hypoplasia of the fovea (HP:0008060)2.92327243
47Hypoplasia of the fovea (HP:0007750)2.92327243
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.92052632
49Dialeptic seizures (HP:0011146)2.89984035
50Genetic anticipation (HP:0003743)2.88315992
51Aplasia/Hypoplasia of the macula (HP:0008059)2.86937319
52Lissencephaly (HP:0001339)2.83517507
53Hypoplasia of the brainstem (HP:0002365)2.82227099
54Aplasia/Hypoplasia of the brainstem (HP:0007362)2.82227099
55Optic disc pallor (HP:0000543)2.80482696
56Failure to thrive in infancy (HP:0001531)2.79029715
57Decreased muscle mass (HP:0003199)2.76899342
58Scanning speech (HP:0002168)2.73552584
59Esotropia (HP:0000565)2.69588950
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.68591340
61Abnormal protein N-linked glycosylation (HP:0012347)2.68591340
62Abnormal protein glycosylation (HP:0012346)2.68591340
63Abnormal glycosylation (HP:0012345)2.68591340
64Hepatic necrosis (HP:0002605)2.68433218
65Dysdiadochokinesis (HP:0002075)2.67903749
66Aplasia/Hypoplasia affecting the retina (HP:0008061)2.64172359
67Lipid accumulation in hepatocytes (HP:0006561)2.63230008
68Agitation (HP:0000713)2.62022209
69Reticulocytopenia (HP:0001896)2.62019519
70Easy fatigability (HP:0003388)2.61596412
71Gait imbalance (HP:0002141)2.60730900
72Split foot (HP:0001839)2.52978594
73Aplastic anemia (HP:0001915)2.51270504
74Increased CSF lactate (HP:0002490)2.50051029
75Absence seizures (HP:0002121)2.49240099
76Inability to walk (HP:0002540)2.48246616
77Abnormality of midbrain morphology (HP:0002418)2.45824330
78Molar tooth sign on MRI (HP:0002419)2.45824330
79Epileptiform EEG discharges (HP:0011182)2.44161985
80Iris hypopigmentation (HP:0007730)2.42991511
81Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41164860
82Increased intramyocellular lipid droplets (HP:0012240)2.40893264
83Generalized tonic-clonic seizures (HP:0002069)2.39645810
84Hypsarrhythmia (HP:0002521)2.38556191
85EEG with generalized epileptiform discharges (HP:0011198)2.37617865
86Abnormality of the heme biosynthetic pathway (HP:0010472)2.36779270
87Diminished movement (HP:0002374)2.36757814
88Ulnar claw (HP:0001178)2.36331149
89Severe visual impairment (HP:0001141)2.36320470
90Amyotrophic lateral sclerosis (HP:0007354)2.36244550
91Acute necrotizing encephalopathy (HP:0006965)2.36237887
92Decreased central vision (HP:0007663)2.32375321
93Medial flaring of the eyebrow (HP:0010747)2.32237818
94Exertional dyspnea (HP:0002875)2.29920517
95Generalized hypopigmentation (HP:0007513)2.29534447
96Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.28867434
97Urinary urgency (HP:0000012)2.28624162
98Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28437440
99Nephronophthisis (HP:0000090)2.28343312
100Drooling (HP:0002307)2.28274577
101Abnormal eating behavior (HP:0100738)2.22928415
102Macrocytic anemia (HP:0001972)2.22713649
103Congenital sensorineural hearing impairment (HP:0008527)2.21825480
104Respiratory difficulties (HP:0002880)2.19395893
105Muscular hypotonia of the trunk (HP:0008936)2.19085777
106Abnormal hair laboratory examination (HP:0003328)2.18735835
107Spastic tetraplegia (HP:0002510)2.18433072
108Pancreatic cysts (HP:0001737)2.18295962
109Prostate neoplasm (HP:0100787)2.17226330
110Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16752867
111Broad-based gait (HP:0002136)2.15226363
112Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13710949
113Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13710949
114Flat occiput (HP:0005469)2.13040379
115Protruding tongue (HP:0010808)2.11875055
116Pallor (HP:0000980)2.09764768
117Ocular albinism (HP:0001107)2.09448799
118Hypokinesia (HP:0002375)2.09344732
119Poor suck (HP:0002033)2.08926335
120Nephrogenic diabetes insipidus (HP:0009806)2.08905133
121IgM deficiency (HP:0002850)2.08335301
122Increased serum lactate (HP:0002151)2.07787340
123Abnormal mitochondria in muscle tissue (HP:0008316)2.06957951
124Acute lymphatic leukemia (HP:0006721)2.06944424
125Attenuation of retinal blood vessels (HP:0007843)2.06075167
126Excessive salivation (HP:0003781)2.04919151
127Atrophy/Degeneration involving motor neurons (HP:0007373)2.04878096
128True hermaphroditism (HP:0010459)2.04389866
129Abnormality of the prostate (HP:0008775)2.04298776
130Biconcave vertebral bodies (HP:0004586)2.04165682
131Abnormality of the labia minora (HP:0012880)2.03654475
132Mutism (HP:0002300)2.02979281
133Thrombocytosis (HP:0001894)2.00607737
134Abnormality of binocular vision (HP:0011514)1.99729475
135Diplopia (HP:0000651)1.99729475
136Postural instability (HP:0002172)1.99256067
137Congenital, generalized hypertrichosis (HP:0004540)1.98577834
138Cerebral edema (HP:0002181)1.94795373
139Pancreatic fibrosis (HP:0100732)1.94525963
140Lactic acidosis (HP:0003128)1.93898202
141Late onset (HP:0003584)1.92663582
142Myositis (HP:0100614)1.92325674
143Exercise intolerance (HP:0003546)1.92097343
144Supranuclear gaze palsy (HP:0000605)1.92090434
145Visual hallucinations (HP:0002367)1.91780835
146Increased corneal curvature (HP:0100692)1.90382006
147Keratoconus (HP:0000563)1.90382006
148Retinal dysplasia (HP:0007973)1.90149133
149Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89564481
150Abnormality of the vocal cords (HP:0008777)1.88395524
151Pachygyria (HP:0001302)1.88227422
152Congenital primary aphakia (HP:0007707)1.87768309
153Tubulointerstitial nephritis (HP:0001970)1.86984195
154Acute encephalopathy (HP:0006846)1.86908057
155Chronic hepatic failure (HP:0100626)1.85828887
156Labial hypoplasia (HP:0000066)1.85361718
157Gonadotropin excess (HP:0000837)1.84890341
158Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.83353960
159Increased muscle lipid content (HP:0009058)1.82014715
160Prolonged bleeding time (HP:0003010)1.82006214
161Delusions (HP:0000746)1.81823649
162Depression (HP:0000716)1.81493056
163Urinary bladder sphincter dysfunction (HP:0002839)1.80973727
164Abnormality of the renal medulla (HP:0100957)1.80164170
165Sclerocornea (HP:0000647)1.78377122
166Exotropia (HP:0000577)1.78084372
167Aplasia/Hypoplasia of the tibia (HP:0005772)1.77580751
168Impaired vibration sensation in the lower limbs (HP:0002166)1.76062996
169Gastroesophageal reflux (HP:0002020)1.75793874
170Spastic tetraparesis (HP:0001285)1.74430798
171Horizontal nystagmus (HP:0000666)1.74090812
172Generalized myoclonic seizures (HP:0002123)1.73167999
173Fair hair (HP:0002286)1.72641171
174Bradykinesia (HP:0002067)1.72584197
175Progressive macrocephaly (HP:0004481)1.72159992
176Hemiparesis (HP:0001269)1.72004088
177Heterochromia iridis (HP:0001100)1.70687124
178Dynein arm defect of respiratory motile cilia (HP:0012255)1.70060568
179Absent/shortened dynein arms (HP:0200106)1.70060568
180Abnormal ciliary motility (HP:0012262)1.70026524
181Bradycardia (HP:0001662)1.68888754
182Aplasia/hypoplasia of the uterus (HP:0008684)1.68884557
183Slow saccadic eye movements (HP:0000514)1.68459544
184Elevated erythrocyte sedimentation rate (HP:0003565)1.67164950
185Patchy hypopigmentation of hair (HP:0011365)1.66969632
186Pancytopenia (HP:0001876)1.66933558
187Abnormality of renal resorption (HP:0011038)1.66692226
188Absent hair (HP:0002298)1.65741375
189Asplenia (HP:0001746)1.65694361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.39721113
2TNIK4.83088069
3CASK4.75812745
4SRPK14.68903334
5PINK13.44706431
6TRIM282.63023348
7STK162.48708624
8BCR2.48076226
9MKNK22.33853786
10MAP3K42.33772784
11CDK192.30462268
12TLK12.27850944
13WNK32.19307142
14MUSK10.0137597
15DYRK21.86749599
16PNCK1.85829493
17PRKG21.80550373
18MINK11.71534375
19MKNK11.68684238
20MAP3K121.67133230
21TXK1.66056159
22SIK31.65678693
23NTRK21.62078407
24NME21.56231148
25DYRK1A1.53110971
26CSNK1G11.50573071
27CSNK1A1L1.48966775
28PRKCG1.47039276
29KIT1.45313473
30ERBB31.41916541
31FES1.41395664
32CCNB11.41135653
33CAMKK21.38246965
34FRK1.38088708
35MAP2K41.37506641
36TEC1.35777376
37GRK11.35636056
38PHKG11.27081009
39PHKG21.27081009
40KSR11.26025937
41MAP2K71.19240101
42PLK21.16214706
43MAP3K111.11013642
44EIF2AK21.10942734
45ADRBK21.10865955
46SIK21.10248049
47ACVR1B1.06104315
48MAPKAPK51.04942591
49CAMK11.00711571
50CDK50.99920308
51NLK0.99187158
52EPHA40.93263384
53CDK180.89071966
54TESK20.87155041
55BMPR1B0.85517106
56GRK70.84934766
57MATK0.81153802
58BUB10.79456004
59CDK140.79131737
60VRK10.79089093
61INSRR0.77305387
62OXSR10.76710087
63CDK150.76444499
64DAPK20.75721478
65MAP4K20.75572366
66CDK11A0.73981319
67LIMK10.70872001
68PRKCZ0.69586384
69TESK10.69451030
70PKN10.68187116
71PAK30.67589378
72EIF2AK30.67094876
73YES10.66940017
74TIE10.64971043
75BLK0.64867433
76NEK60.64757581
77TAOK30.63588665
78PRKACB0.63250969
79BTK0.61746771
80CSNK1G30.60749055
81TGFBR20.59480913
82IRAK40.59375499
83NME10.59264253
84MAPK130.58851736
85MARK30.58003779
86IRAK10.57161087
87MAP4K10.56646565
88LYN0.56263857
89KDR0.56024705
90PIK3CA0.55525598
91BCKDK0.52950522
92CSNK1D0.52602627
93CAMK40.52462465
94MAPK40.52257892
95TNK20.51169856
96CAMK2B0.49971749
97PIM20.49450129
98IRAK20.46977594
99MAP2K60.46219395
100SYK0.46165470
101CSNK1A10.46021019
102MYLK0.45682943
103STK390.45624027
104MST40.43944336
105RIPK40.43776214
106WEE10.43508271
107GRK50.43101150
108BRD40.42418077
109CDK80.42331978
110CLK10.42304080
111CSNK1E0.40751768
112PRKAA10.40042809
113TSSK60.39591511
114PRKACG0.38867054
115NTRK30.38018198
116UHMK10.37242328
117CSF1R0.37041615
118RPS6KA30.36673946
119STK110.36380255
120ZAK0.35737497
121PRKAA20.35656867
122MAP3K50.35572249
123PRKCH0.33452071
124IKBKB0.33399499
125EIF2AK10.32553355
126PRKCB0.32551092
127PRKCE0.32085297
128DYRK1B0.31809083
129MAP3K90.31496152
130CDK30.31449763
131SGK10.31018947
132CSNK2A10.30973479
133PRKCA0.30659264
134PRPF4B0.30479539
135LATS20.30457790
136CAMK2D0.30227150
137CAMKK10.30128589
138PRKACA0.30000886
139PRKCI0.29982836
140MAPK100.29787363
141ADRBK10.29606815
142LCK0.28501709
143CAMK2A0.28283669
144IRAK30.28055911
145TGFBR10.27840464
146IKBKE0.27786933
147RPS6KA50.27762377
148GSK3B0.27588235
149CSNK1G20.27526326
150ERBB40.27456968
151MAPK90.27298084
152CSNK2A20.27242498
153FGR0.26350086
154PIK3CG0.25153293
155TBK10.24879516
156DAPK30.24722457
157MAPK120.24286302
158HIPK20.23568926
159DAPK10.23290327
160FLT30.21073168
161PIM10.20531236
162CDK70.20070641
163DYRK30.19263175
164MAP3K70.19002472
165MAP3K140.18936665
166ZAP700.18527429
167CAMK2G0.18311690
168PRKG10.18162523

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.63186860
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.71434693
3Protein export_Homo sapiens_hsa030603.13612455
4Oxidative phosphorylation_Homo sapiens_hsa001902.91970522
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.78277124
6Amphetamine addiction_Homo sapiens_hsa050312.62837246
7Nicotine addiction_Homo sapiens_hsa050332.39924557
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.32247754
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29004880
10Parkinsons disease_Homo sapiens_hsa050122.23718461
11Fatty acid elongation_Homo sapiens_hsa000622.11894562
12Homologous recombination_Homo sapiens_hsa034402.04112210
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.94662876
14RNA polymerase_Homo sapiens_hsa030201.91258760
15Folate biosynthesis_Homo sapiens_hsa007901.89902097
16DNA replication_Homo sapiens_hsa030301.81082512
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76362155
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.71037998
19Alzheimers disease_Homo sapiens_hsa050101.69483251
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.65560079
21Sphingolipid metabolism_Homo sapiens_hsa006001.63029334
22Huntingtons disease_Homo sapiens_hsa050161.50637379
23Sulfur relay system_Homo sapiens_hsa041221.44136268
24Pyrimidine metabolism_Homo sapiens_hsa002401.42322934
25Insulin secretion_Homo sapiens_hsa049111.41338718
26Morphine addiction_Homo sapiens_hsa050321.40259057
27Serotonergic synapse_Homo sapiens_hsa047261.39298702
28Long-term depression_Homo sapiens_hsa047301.37909233
29Phototransduction_Homo sapiens_hsa047441.37322522
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36406706
31Butanoate metabolism_Homo sapiens_hsa006501.33291010
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27477234
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27380267
34Glutamatergic synapse_Homo sapiens_hsa047241.25837343
35Fanconi anemia pathway_Homo sapiens_hsa034601.25325531
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23281518
37Purine metabolism_Homo sapiens_hsa002301.22743293
38Axon guidance_Homo sapiens_hsa043601.20534927
39GABAergic synapse_Homo sapiens_hsa047271.20317230
40Taste transduction_Homo sapiens_hsa047421.20110093
41Long-term potentiation_Homo sapiens_hsa047201.19866349
42Olfactory transduction_Homo sapiens_hsa047401.19025548
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18746131
44N-Glycan biosynthesis_Homo sapiens_hsa005101.13236570
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.13160486
46Gap junction_Homo sapiens_hsa045401.09244667
47Circadian entrainment_Homo sapiens_hsa047131.04799618
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01294531
49Calcium signaling pathway_Homo sapiens_hsa040200.98870524
50Nucleotide excision repair_Homo sapiens_hsa034200.97523681
51Spliceosome_Homo sapiens_hsa030400.95318119
52Oocyte meiosis_Homo sapiens_hsa041140.95279304
53Gastric acid secretion_Homo sapiens_hsa049710.95213118
54Oxytocin signaling pathway_Homo sapiens_hsa049210.93336121
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91798856
56Hematopoietic cell lineage_Homo sapiens_hsa046400.91288706
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90449446
58Primary immunodeficiency_Homo sapiens_hsa053400.89582533
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88077542
60Salivary secretion_Homo sapiens_hsa049700.87494313
61Base excision repair_Homo sapiens_hsa034100.86885642
62Renin secretion_Homo sapiens_hsa049240.82874220
63Arachidonic acid metabolism_Homo sapiens_hsa005900.82431023
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81740120
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81685183
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80273963
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79432551
68Proteasome_Homo sapiens_hsa030500.77316462
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76883006
70Basal transcription factors_Homo sapiens_hsa030220.75968890
71cAMP signaling pathway_Homo sapiens_hsa040240.75310716
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73634375
73Tyrosine metabolism_Homo sapiens_hsa003500.71135566
74Malaria_Homo sapiens_hsa051440.68252141
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65894516
76* Metabolic pathways_Homo sapiens_hsa011000.63197773
77African trypanosomiasis_Homo sapiens_hsa051430.62328226
78Platelet activation_Homo sapiens_hsa046110.61122472
79Vitamin digestion and absorption_Homo sapiens_hsa049770.61011375
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57488135
81Cardiac muscle contraction_Homo sapiens_hsa042600.56984105
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56470464
83Synaptic vesicle cycle_Homo sapiens_hsa047210.56380055
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55738478
85Type II diabetes mellitus_Homo sapiens_hsa049300.55021536
86Rheumatoid arthritis_Homo sapiens_hsa053230.54985312
87Tryptophan metabolism_Homo sapiens_hsa003800.54963768
88Ether lipid metabolism_Homo sapiens_hsa005650.54458382
89Melanogenesis_Homo sapiens_hsa049160.54145227
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52809186
91Mismatch repair_Homo sapiens_hsa034300.50951249
92ABC transporters_Homo sapiens_hsa020100.50841493
93Collecting duct acid secretion_Homo sapiens_hsa049660.50480607
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50405662
95Regulation of autophagy_Homo sapiens_hsa041400.49431003
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49041719
97Linoleic acid metabolism_Homo sapiens_hsa005910.47809480
98Ovarian steroidogenesis_Homo sapiens_hsa049130.47738551
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47245422
100Ras signaling pathway_Homo sapiens_hsa040140.46287681
101RNA degradation_Homo sapiens_hsa030180.46183488
102GnRH signaling pathway_Homo sapiens_hsa049120.45770863
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45356548
104Allograft rejection_Homo sapiens_hsa053300.43866578
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43470335
106Non-homologous end-joining_Homo sapiens_hsa034500.43301345
107Acute myeloid leukemia_Homo sapiens_hsa052210.42960338
108Estrogen signaling pathway_Homo sapiens_hsa049150.42074623
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41771760
110Cholinergic synapse_Homo sapiens_hsa047250.41577058
111Dopaminergic synapse_Homo sapiens_hsa047280.41433625
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40765990
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.39854312
114Thyroid cancer_Homo sapiens_hsa052160.39795994
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39781048
116B cell receptor signaling pathway_Homo sapiens_hsa046620.38803046
117Retinol metabolism_Homo sapiens_hsa008300.38732863
118Alcoholism_Homo sapiens_hsa050340.38189992
119Sulfur metabolism_Homo sapiens_hsa009200.37681120
120Cocaine addiction_Homo sapiens_hsa050300.37349334
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36813718
122Measles_Homo sapiens_hsa051620.33870789
123Chemical carcinogenesis_Homo sapiens_hsa052040.33835782
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.33449959
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.33382559
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33326583
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33065923
128Bile secretion_Homo sapiens_hsa049760.32974007
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.32816044
130Steroid biosynthesis_Homo sapiens_hsa001000.32755661
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32740062
132Wnt signaling pathway_Homo sapiens_hsa043100.32522657
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31493606
134* Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31075759
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30337703
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29741314
137Asthma_Homo sapiens_hsa053100.28184639
138Herpes simplex infection_Homo sapiens_hsa051680.27510247
139Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27392905
140Vibrio cholerae infection_Homo sapiens_hsa051100.26971728
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.26894504
142Arginine and proline metabolism_Homo sapiens_hsa003300.26209634
143Glycerolipid metabolism_Homo sapiens_hsa005610.25404552
144Pyruvate metabolism_Homo sapiens_hsa006200.25223250
145Nitrogen metabolism_Homo sapiens_hsa009100.25088871
146Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24513451
147Propanoate metabolism_Homo sapiens_hsa006400.23921965
148Fatty acid biosynthesis_Homo sapiens_hsa000610.22987700
149Hippo signaling pathway_Homo sapiens_hsa043900.22171832
150Primary bile acid biosynthesis_Homo sapiens_hsa001200.21655784
151Cysteine and methionine metabolism_Homo sapiens_hsa002700.21540510
152Phagosome_Homo sapiens_hsa041450.19180808
153mRNA surveillance pathway_Homo sapiens_hsa030150.17981567
154Circadian rhythm_Homo sapiens_hsa047100.17967974
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17768258

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