GALP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1facial nerve structural organization (GO:0021612)9.14414019
2cranial nerve structural organization (GO:0021604)6.70708834
3regulation of mitochondrial translation (GO:0070129)5.04454617
4anatomical structure arrangement (GO:0048532)4.22882393
5sequestering of actin monomers (GO:0042989)4.14046917
6exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.07230528
7nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.96093074
8mitochondrial respiratory chain complex assembly (GO:0033108)3.93167968
9protein complex biogenesis (GO:0070271)3.91007531
10organelle disassembly (GO:1903008)3.86751890
11chaperone-mediated protein transport (GO:0072321)3.74192301
12histone H2A acetylation (GO:0043968)3.72923284
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.66152293
14respiratory chain complex IV assembly (GO:0008535)3.64756482
15spliceosomal snRNP assembly (GO:0000387)3.53967098
16negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.52361261
17lipopolysaccharide biosynthetic process (GO:0009103)3.50036394
18proteasome assembly (GO:0043248)3.46448121
19DNA deamination (GO:0045006)3.45932101
20DNA ligation (GO:0006266)3.42530886
21protein neddylation (GO:0045116)3.40853164
22DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.37955852
23cytochrome complex assembly (GO:0017004)3.37020671
24signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.36158214
25signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.36158214
26signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.36158214
27regulation of cellular amino acid metabolic process (GO:0006521)3.35736968
28DNA strand elongation involved in DNA replication (GO:0006271)3.34819602
29intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.32097467
30signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.32097467
31signal transduction involved in cell cycle checkpoint (GO:0072395)3.30925201
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.29125653
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.29125653
34NADH dehydrogenase complex assembly (GO:0010257)3.29125653
35DNA double-strand break processing (GO:0000729)3.28655780
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.28424685
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27676322
38DNA methylation involved in gamete generation (GO:0043046)3.26457138
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.24711852
40negative regulation of ligase activity (GO:0051352)3.24711852
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24222324
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.19328553
43signal transduction involved in DNA damage checkpoint (GO:0072422)3.19328553
44hyperosmotic salinity response (GO:0042538)3.18885184
45DNA strand elongation (GO:0022616)3.17138363
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.16491066
47histone mRNA metabolic process (GO:0008334)3.16031340
48negative regulation of cell cycle G2/M phase transition (GO:1902750)3.15915319
49sphingosine metabolic process (GO:0006670)3.14232805
50negative regulation of DNA recombination (GO:0045910)3.13739673
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.13063588
52pre-miRNA processing (GO:0031054)3.12688141
53regulation of development, heterochronic (GO:0040034)3.11150511
54motor neuron axon guidance (GO:0008045)3.07668201
55ncRNA catabolic process (GO:0034661)3.07004975
56GTP biosynthetic process (GO:0006183)3.04743632
57non-recombinational repair (GO:0000726)3.02735924
58double-strand break repair via nonhomologous end joining (GO:0006303)3.02735924
59DNA replication initiation (GO:0006270)2.99671116
60centriole replication (GO:0007099)2.97861473
61lipopolysaccharide metabolic process (GO:0008653)2.96993434
62neural tube formation (GO:0001841)2.96927067
63oligosaccharide biosynthetic process (GO:0009312)2.93114820
64regulation of timing of cell differentiation (GO:0048505)2.91522071
65axonal fasciculation (GO:0007413)2.91008625
66platelet dense granule organization (GO:0060155)2.90510035
67pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.88789133
68base-excision repair, AP site formation (GO:0006285)2.87044614
69piRNA metabolic process (GO:0034587)2.86928399
70regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.86214707
71glyoxylate metabolic process (GO:0046487)2.85471519
72establishment of protein localization to mitochondrial membrane (GO:0090151)2.84656681
73chromatin remodeling at centromere (GO:0031055)2.83896343
74telomere maintenance via semi-conservative replication (GO:0032201)2.83642324
75behavioral response to nicotine (GO:0035095)2.82670841
76indole-containing compound catabolic process (GO:0042436)2.81159073
77indolalkylamine catabolic process (GO:0046218)2.81159073
78tryptophan catabolic process (GO:0006569)2.81159073
79nonmotile primary cilium assembly (GO:0035058)2.79696418
80protein localization to synapse (GO:0035418)2.75790511
81retinal ganglion cell axon guidance (GO:0031290)2.75769136
82limb bud formation (GO:0060174)2.74825571
83pyrimidine nucleotide catabolic process (GO:0006244)2.73138591
84diol metabolic process (GO:0034311)2.72764545
85positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.72660760
86regulation of meiosis I (GO:0060631)2.72603188
87reciprocal DNA recombination (GO:0035825)2.71760478
88reciprocal meiotic recombination (GO:0007131)2.71760478
89ATP synthesis coupled proton transport (GO:0015986)2.71707009
90energy coupled proton transport, down electrochemical gradient (GO:0015985)2.71707009
91intraciliary transport (GO:0042073)2.71629854
92female gonad development (GO:0008585)2.71253713
93establishment of mitochondrion localization (GO:0051654)2.68841317
94respiratory electron transport chain (GO:0022904)2.68068944
95peptidyl-histidine modification (GO:0018202)2.67763778
96nucleotide-excision repair, DNA gap filling (GO:0006297)2.63103304
97electron transport chain (GO:0022900)2.62839721
98regulation of collateral sprouting (GO:0048670)2.61558692
99hippocampus development (GO:0021766)2.60810157
100UTP biosynthetic process (GO:0006228)2.60779163

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.45818647
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.84449803
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.01963965
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.99309835
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.94567107
6IGF1R_20145208_ChIP-Seq_DFB_Human2.75709084
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.73269904
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69273474
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.67197924
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62010891
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.61681770
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52127287
13E2F7_22180533_ChIP-Seq_HELA_Human2.41534975
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.36217654
15POU5F1_16153702_ChIP-ChIP_HESCs_Human2.35810941
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23993544
17ZNF274_21170338_ChIP-Seq_K562_Hela2.16346691
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.08069498
19SOX2_18555785_ChIP-Seq_MESCs_Mouse2.05255321
20SOX2_16153702_ChIP-ChIP_HESCs_Human2.03919601
21MYC_18940864_ChIP-ChIP_HL60_Human1.99472590
22EZH2_22144423_ChIP-Seq_EOC_Human1.99056063
23THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90525132
24POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.89381306
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59802540
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.59307941
27VDR_23849224_ChIP-Seq_CD4+_Human1.58713282
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55601325
29NANOG_16153702_ChIP-ChIP_HESCs_Human1.52476297
30CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.52379180
31SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.51813755
32ELK1_19687146_ChIP-ChIP_HELA_Human1.49337601
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49154383
34GABP_19822575_ChIP-Seq_HepG2_Human1.47958260
35P300_19829295_ChIP-Seq_ESCs_Human1.43961679
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.40959165
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40475693
38TP53_22573176_ChIP-Seq_HFKS_Human1.39870519
39FOXP3_21729870_ChIP-Seq_TREG_Human1.37619975
40EWS_26573619_Chip-Seq_HEK293_Human1.36554113
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36051458
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30890008
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28811284
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28668581
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27267255
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27240495
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26178154
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.25975810
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24796792
50IRF1_19129219_ChIP-ChIP_H3396_Human1.24400670
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23792761
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23718597
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23056998
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22947788
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.22308629
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21822703
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21809279
58HTT_18923047_ChIP-ChIP_STHdh_Human1.21318469
59AR_21572438_ChIP-Seq_LNCaP_Human1.18261763
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17303973
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.16550195
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14315926
63VDR_22108803_ChIP-Seq_LS180_Human1.13876574
64* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13727729
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10016705
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06602179
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.06319463
68TAF15_26573619_Chip-Seq_HEK293_Human1.05919352
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.05891713
70NCOR_22424771_ChIP-Seq_293T_Human1.05736303
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04484488
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.04379569
73GBX2_23144817_ChIP-Seq_PC3_Human1.01425492
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01261416
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99315673
76DCP1A_22483619_ChIP-Seq_HELA_Human0.98868295
77CBX2_27304074_Chip-Seq_ESCs_Mouse0.97884065
78SMAD3_21741376_ChIP-Seq_EPCs_Human0.97213209
79RNF2_27304074_Chip-Seq_NSC_Mouse0.96998649
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96933503
81MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95161595
82FUS_26573619_Chip-Seq_HEK293_Human0.93898259
83PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93649205
84E2F1_21310950_ChIP-Seq_MCF-7_Human0.93064150
85SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92191447
86NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91444281
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91062705
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91044108
89HOXB7_26014856_ChIP-Seq_BT474_Human0.90259768
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87633755
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87140958
92HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86550558
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86505606
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86149382
95CBP_20019798_ChIP-Seq_JUKART_Human0.86149382
96TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86126362
97EGR1_19032775_ChIP-ChIP_M12_Human0.86042388
98SOX2_19829295_ChIP-Seq_ESCs_Human0.85093564
99NANOG_19829295_ChIP-Seq_ESCs_Human0.85093564
100POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.83387493

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.70092374
2MP0002102_abnormal_ear_morphology4.21150358
3MP0003283_abnormal_digestive_organ3.47507081
4MP0008789_abnormal_olfactory_epithelium3.34348145
5MP0006292_abnormal_olfactory_placode3.22305461
6MP0002837_dystrophic_cardiac_calcinosis3.09675338
7MP0003136_yellow_coat_color2.94256491
8MP0002653_abnormal_ependyma_morphology2.80928148
9MP0003122_maternal_imprinting2.79623687
10MP0005499_abnormal_olfactory_system2.66951601
11MP0005394_taste/olfaction_phenotype2.66951601
12MP0005171_absent_coat_pigmentation2.55139254
13MP0001529_abnormal_vocalization2.30171925
14MP0003646_muscle_fatigue2.17975852
15MP0010030_abnormal_orbit_morphology2.10462319
16MP0002822_catalepsy2.09956504
17MP0004133_heterotaxia2.08433759
18MP0004147_increased_porphyrin_level2.08357910
19MP0002233_abnormal_nose_morphology2.07955549
20MP0005423_abnormal_somatic_nervous2.03284935
21MP0003890_abnormal_embryonic-extraembry2.00414981
22MP0000749_muscle_degeneration1.78698130
23MP0004142_abnormal_muscle_tone1.77356038
24MP0006035_abnormal_mitochondrial_morpho1.75834760
25MP0002736_abnormal_nociception_after1.66670377
26MP0005253_abnormal_eye_physiology1.64419688
27MP0008932_abnormal_embryonic_tissue1.63739376
28MP0001486_abnormal_startle_reflex1.63569794
29MP0003011_delayed_dark_adaptation1.60761854
30MP0000049_abnormal_middle_ear1.56768629
31MP0003121_genomic_imprinting1.55935020
32MP0001984_abnormal_olfaction1.55228417
33MP0002938_white_spotting1.51771723
34MP0005377_hearing/vestibular/ear_phenot1.48374520
35MP0003878_abnormal_ear_physiology1.48374520
36MP0006276_abnormal_autonomic_nervous1.44127886
37MP0003693_abnormal_embryo_hatching1.37430254
38MP0005386_behavior/neurological_phenoty1.37089441
39MP0004924_abnormal_behavior1.37089441
40MP0010094_abnormal_chromosome_stability1.36253230
41MP0009046_muscle_twitch1.34333933
42MP0003119_abnormal_digestive_system1.33214472
43MP0003937_abnormal_limbs/digits/tail_de1.32370603
44MP0000778_abnormal_nervous_system1.30415962
45MP0002090_abnormal_vision1.30179546
46MP0000428_abnormal_craniofacial_morphol1.29459371
47MP0003938_abnormal_ear_development1.24538299
48MP0008877_abnormal_DNA_methylation1.23516494
49MP0002184_abnormal_innervation1.18040897
50MP0003755_abnormal_palate_morphology1.16300939
51MP0005075_abnormal_melanosome_morpholog1.15535289
52MP0000569_abnormal_digit_pigmentation1.14022259
53MP0001968_abnormal_touch/_nociception1.13853489
54MP0005085_abnormal_gallbladder_physiolo1.12558458
55MP0002734_abnormal_mechanical_nocicepti1.10739455
56MP0008057_abnormal_DNA_replication1.08307241
57MP0005551_abnormal_eye_electrophysiolog1.07939235
58MP0002751_abnormal_autonomic_nervous1.07206821
59MP0002752_abnormal_somatic_nervous1.01702899
60MP0003385_abnormal_body_wall1.00779498
61MP0006072_abnormal_retinal_apoptosis1.00483940
62MP0002277_abnormal_respiratory_mucosa0.99778659
63MP0003718_maternal_effect0.97023942
64MP0003077_abnormal_cell_cycle0.97016904
65MP0001293_anophthalmia0.96519636
66MP0008058_abnormal_DNA_repair0.95652603
67MP0000566_synostosis0.93864431
68MP0002111_abnormal_tail_morphology0.90021645
69MP0003137_abnormal_impulse_conducting0.89840551
70MP0002272_abnormal_nervous_system0.89513012
71MP0002733_abnormal_thermal_nociception0.87566166
72MP0000372_irregular_coat_pigmentation0.87313307
73MP0002557_abnormal_social/conspecific_i0.86875169
74MP0002067_abnormal_sensory_capabilities0.85130236
75MP0002735_abnormal_chemical_nociception0.83539419
76MP0004957_abnormal_blastocyst_morpholog0.83287789
77MP0003632_abnormal_nervous_system0.83267551
78MP0009745_abnormal_behavioral_response0.81967408
79MP0000026_abnormal_inner_ear0.81010051
80MP0003861_abnormal_nervous_system0.79562306
81MP0005670_abnormal_white_adipose0.73660682
82MP0001905_abnormal_dopamine_level0.72183195
83MP0000631_abnormal_neuroendocrine_gland0.71524489
84MP0005391_vision/eye_phenotype0.70453822
85MP0005167_abnormal_blood-brain_barrier0.67717413
86MP0006036_abnormal_mitochondrial_physio0.67339075
87MP0002249_abnormal_larynx_morphology0.66468110
88MP0001145_abnormal_male_reproductive0.65768220
89MP0002064_seizures0.64780702
90MP0000955_abnormal_spinal_cord0.64366903
91MP0002098_abnormal_vibrissa_morphology0.63169621
92MP0005195_abnormal_posterior_eye0.62497557
93MP0001963_abnormal_hearing_physiology0.62466316
94* MP0000653_abnormal_sex_gland0.62301738
95MP0001970_abnormal_pain_threshold0.62132926
96MP0006054_spinal_hemorrhage0.61627610
97MP0001764_abnormal_homeostasis0.61529869
98MP0002882_abnormal_neuron_morphology0.61099285
99MP0002177_abnormal_outer_ear0.60468562
100MP0005248_abnormal_Harderian_gland0.59288727

Predicted human phenotypes

RankGene SetZ-score
1Chin dimple (HP:0010751)5.01380888
2Acute necrotizing encephalopathy (HP:0006965)4.30219994
3Abnormality of the labia minora (HP:0012880)4.05304152
4Abnormal mitochondria in muscle tissue (HP:0008316)4.02277010
5Acute encephalopathy (HP:0006846)4.01959011
6Progressive macrocephaly (HP:0004481)3.52323897
7Supernumerary spleens (HP:0009799)3.41953211
8Aplasia/Hypoplasia of the tibia (HP:0005772)3.15651278
9Hyperglycinemia (HP:0002154)3.15453152
10Short tibia (HP:0005736)3.07446893
11Carpal bone hypoplasia (HP:0001498)3.06714309
12Mitochondrial inheritance (HP:0001427)3.05283788
13Birth length less than 3rd percentile (HP:0003561)2.94918024
14Nonprogressive disorder (HP:0003680)2.93584498
15Pancreatic cysts (HP:0001737)2.89308206
16Spinal muscular atrophy (HP:0007269)2.80966763
17Colon cancer (HP:0003003)2.72866677
18Abnormal lung lobation (HP:0002101)2.70528495
19Focal motor seizures (HP:0011153)2.68365864
20Hip dysplasia (HP:0001385)2.66412127
21Ulnar claw (HP:0001178)2.62609190
22Hyperglycinuria (HP:0003108)2.55632056
23Labial hypoplasia (HP:0000066)2.53175726
24Increased CSF lactate (HP:0002490)2.52456491
25Hypoplastic female external genitalia (HP:0012815)2.51592817
26Abnormality of midbrain morphology (HP:0002418)2.47854257
27Molar tooth sign on MRI (HP:0002419)2.47854257
28Patellar aplasia (HP:0006443)2.39719898
29Abnormality of serine family amino acid metabolism (HP:0010894)2.39542026
30Abnormality of glycine metabolism (HP:0010895)2.39542026
31Pancreatic fibrosis (HP:0100732)2.39505472
32Hepatocellular necrosis (HP:0001404)2.39488360
33Proximal amyotrophy (HP:0007126)2.38261859
34Absent septum pellucidum (HP:0001331)2.37564919
35Cerebral edema (HP:0002181)2.36740497
36Diaphragmatic weakness (HP:0009113)2.34045897
37Leukodystrophy (HP:0002415)2.33185536
38Respiratory failure (HP:0002878)2.33166020
39Small hand (HP:0200055)2.31250951
40Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.30939773
41Hepatic necrosis (HP:0002605)2.26024076
42High anterior hairline (HP:0009890)2.22843328
43Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.22517420
44Abnormality of the middle phalanges of the toes (HP:0010183)2.21666854
45Preaxial hand polydactyly (HP:0001177)2.20759359
46Nephronophthisis (HP:0000090)2.20492382
47Aplasia/Hypoplasia of the patella (HP:0006498)2.19700897
48Increased serum pyruvate (HP:0003542)2.19560200
49Medial flaring of the eyebrow (HP:0010747)2.15238044
50Peripheral hypomyelination (HP:0007182)2.14834847
51Broad-based gait (HP:0002136)2.14801844
52True hermaphroditism (HP:0010459)2.14767742
53Amelogenesis imperfecta (HP:0000705)2.13690364
54Type I transferrin isoform profile (HP:0003642)2.12980899
55Abnormality of the septum pellucidum (HP:0007375)2.09931218
56Upper limb muscle weakness (HP:0003484)2.09505523
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.08856599
58Ankyloglossia (HP:0010296)2.07566009
59Median cleft lip (HP:0000161)2.05873972
60Abnormality of the anterior horn cell (HP:0006802)2.05183521
61Degeneration of anterior horn cells (HP:0002398)2.05183521
62Abnormality of the renal medulla (HP:0100957)2.03798776
63Rib fusion (HP:0000902)2.00290442
64Down-sloping shoulders (HP:0200021)1.99002282
65Facial cleft (HP:0002006)1.98446338
66Optic disc pallor (HP:0000543)1.97353956
67Abnormality of the renal cortex (HP:0011035)1.94233002
68Intestinal atresia (HP:0011100)1.94100063
69Stridor (HP:0010307)1.93096081
70Pendular nystagmus (HP:0012043)1.91495942
71Anencephaly (HP:0002323)1.90574249
72Hip contracture (HP:0003273)1.90521499
73Limb-girdle muscle atrophy (HP:0003797)1.89473493
74Abnormality of the labia (HP:0000058)1.88594863
75Split foot (HP:0001839)1.84824495
76Hemivertebrae (HP:0002937)1.84534030
77Chorioretinal coloboma (HP:0000567)1.82675260
78Congenital primary aphakia (HP:0007707)1.82670652
79Rough bone trabeculation (HP:0100670)1.79793556
80Medulloblastoma (HP:0002885)1.79757438
81Abnormality of the phalanges of the hallux (HP:0010057)1.79193565
82Abnormality of glycolysis (HP:0004366)1.79074036
83Cortical dysplasia (HP:0002539)1.78297490
84Opisthotonus (HP:0002179)1.78248287
85Gait imbalance (HP:0002141)1.77067433
86Postaxial hand polydactyly (HP:0001162)1.77011196
87Dandy-Walker malformation (HP:0001305)1.76057025
88Abnormality of the intervertebral disk (HP:0005108)1.74473887
89Abnormality of macular pigmentation (HP:0008002)1.74461282
90Esotropia (HP:0000565)1.72014167
91Redundant skin (HP:0001582)1.71214037
92Postaxial foot polydactyly (HP:0001830)1.70285958
93Lactic acidosis (HP:0003128)1.70224877
94Anophthalmia (HP:0000528)1.70191119
95Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.69274032
96Mixed hearing impairment (HP:0000410)1.68668061
97Septo-optic dysplasia (HP:0100842)1.68631155
98Abnormality of the vocal cords (HP:0008777)1.66883619
99Vaginal atresia (HP:0000148)1.66783018
100Erythroderma (HP:0001019)1.66516192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA47.75484676
2MAP4K24.67071290
3LATS13.39916734
4INSRR2.68105826
5MAP2K72.66893735
6WNK32.64256222
7STK38L2.59855948
8CDC72.51559154
9SRPK12.17274524
10MAP3K42.12297770
11CSNK1A1L1.95683593
12PINK11.92883340
13CSNK1G21.91590801
14CSNK1G31.79682156
15LATS21.76793865
16ZAK1.69451544
17TRIM281.68637225
18TIE11.66475640
19FRK1.62197027
20BCR1.58415164
21ADRBK21.53976323
22CSNK1G11.45426527
23TNIK1.44774787
24UHMK11.44689156
25NME11.43774903
26PLK41.42617532
27BMPR1B1.33251215
28OXSR11.30815480
29GRK11.27630494
30STK391.23886094
31BRSK11.19298091
32BCKDK1.17204184
33PLK31.13579304
34STK161.13146522
35PLK21.12894809
36VRK11.10438932
37PLK11.06405131
38BRSK21.01106664
39NLK1.00244214
40MARK10.95194406
41TTK0.88867211
42VRK20.88727534
43DYRK20.85209998
44BUB10.84369413
45TNK20.83463085
46STK380.83393479
47NEK20.79772016
48WNK40.79430719
49MAPK130.75925685
50FGFR20.71169938
51RPS6KA40.67430727
52SIK30.67402427
53ATR0.64393127
54STK30.59260681
55ERBB30.59213404
56CLK10.58178758
57MAP2K40.58164812
58FER0.54352528
59MAPKAPK30.54094276
60ABL20.52283127
61CHEK20.49011676
62PRKD30.46621401
63RPS6KA50.45686538
64CSNK2A10.45483097
65MKNK20.45357053
66DAPK10.45078605
67MKNK10.44462235
68MINK10.44234652
69CASK0.44112164
70STK110.43115719
71NTRK20.40799512
72MUSK0.38917823
73CSNK1A10.37807014
74CSNK1E0.37435789
75NUAK10.37168842
76EPHB10.36813721
77TYK20.36585548
78ACVR1B0.36317599
79CAMK2B0.36313438
80PRKCE0.35585247
81KDR0.35190183
82PRKAA20.34245543
83DYRK30.33341224
84ADRBK10.33090192
85CDK190.33041305
86ATM0.32429653
87EPHB20.32138232
88CSNK1D0.31773554
89EPHA30.30745193
90DYRK1B0.30513887
91CSNK2A20.29680631
92PRKCG0.28725851
93PRKAA10.27708096
94CDK20.26222074
95MAP3K110.25723655
96DAPK20.24131281
97CDK180.23607257
98CAMK2A0.21889238
99CDK10.21491088
100PRKDC0.21459672

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.73669239
2DNA replication_Homo sapiens_hsa030303.12421623
3Base excision repair_Homo sapiens_hsa034102.89824211
4Oxidative phosphorylation_Homo sapiens_hsa001902.62599336
5Mismatch repair_Homo sapiens_hsa034302.60181117
6Homologous recombination_Homo sapiens_hsa034402.43255996
7RNA polymerase_Homo sapiens_hsa030202.42966782
8Parkinsons disease_Homo sapiens_hsa050122.35376486
9Sulfur relay system_Homo sapiens_hsa041222.31418538
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14855640
11Non-homologous end-joining_Homo sapiens_hsa034502.07959654
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.03319390
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00652092
14Phototransduction_Homo sapiens_hsa047441.96075941
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.83896952
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80647191
17Spliceosome_Homo sapiens_hsa030401.76907433
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.74224228
19Protein export_Homo sapiens_hsa030601.72094545
20Huntingtons disease_Homo sapiens_hsa050161.67810515
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66460345
22Fanconi anemia pathway_Homo sapiens_hsa034601.63986544
23Nicotine addiction_Homo sapiens_hsa050331.62023119
24Pyrimidine metabolism_Homo sapiens_hsa002401.58581048
25Alzheimers disease_Homo sapiens_hsa050101.51177066
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50297735
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45627903
28Propanoate metabolism_Homo sapiens_hsa006401.42074352
29RNA degradation_Homo sapiens_hsa030181.41864389
30Butanoate metabolism_Homo sapiens_hsa006501.40289840
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.21122715
32Regulation of autophagy_Homo sapiens_hsa041401.20731350
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17969023
34Cell cycle_Homo sapiens_hsa041101.16674695
35RNA transport_Homo sapiens_hsa030131.14483186
36Fatty acid elongation_Homo sapiens_hsa000621.13517900
37Steroid biosynthesis_Homo sapiens_hsa001001.11093017
38Nucleotide excision repair_Homo sapiens_hsa034201.07263090
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00457819
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00279881
41Cardiac muscle contraction_Homo sapiens_hsa042601.00214635
42Pyruvate metabolism_Homo sapiens_hsa006201.00059015
43Folate biosynthesis_Homo sapiens_hsa007900.99355678
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96103684
45Tryptophan metabolism_Homo sapiens_hsa003800.93614478
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.91390529
47Retinol metabolism_Homo sapiens_hsa008300.89776439
48Peroxisome_Homo sapiens_hsa041460.89745721
49Taste transduction_Homo sapiens_hsa047420.88887579
50Hedgehog signaling pathway_Homo sapiens_hsa043400.88449486
51Selenocompound metabolism_Homo sapiens_hsa004500.86394599
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85820705
53mRNA surveillance pathway_Homo sapiens_hsa030150.85367754
54Basal transcription factors_Homo sapiens_hsa030220.84888984
55Basal cell carcinoma_Homo sapiens_hsa052170.83283199
56N-Glycan biosynthesis_Homo sapiens_hsa005100.82739242
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80635435
58Purine metabolism_Homo sapiens_hsa002300.78955835
59Metabolic pathways_Homo sapiens_hsa011000.78655265
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78630086
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78357344
62Phenylalanine metabolism_Homo sapiens_hsa003600.78269220
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77078483
64Ether lipid metabolism_Homo sapiens_hsa005650.76840057
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76793319
66Biosynthesis of amino acids_Homo sapiens_hsa012300.75470422
67Fatty acid metabolism_Homo sapiens_hsa012120.74575143
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73271185
69Arginine and proline metabolism_Homo sapiens_hsa003300.71705916
70Linoleic acid metabolism_Homo sapiens_hsa005910.69730610
71GABAergic synapse_Homo sapiens_hsa047270.69245776
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.68863218
73Glutathione metabolism_Homo sapiens_hsa004800.68385018
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68353298
75Histidine metabolism_Homo sapiens_hsa003400.61166903
76Olfactory transduction_Homo sapiens_hsa047400.60775451
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60427966
78Fatty acid biosynthesis_Homo sapiens_hsa000610.59200742
79Oocyte meiosis_Homo sapiens_hsa041140.58927842
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.57489520
81Tyrosine metabolism_Homo sapiens_hsa003500.54176503
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53631771
83beta-Alanine metabolism_Homo sapiens_hsa004100.52912663
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52138854
85Morphine addiction_Homo sapiens_hsa050320.50949742
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50695953
87Chemical carcinogenesis_Homo sapiens_hsa052040.50349103
88TGF-beta signaling pathway_Homo sapiens_hsa043500.50087423
89Ribosome_Homo sapiens_hsa030100.49594413
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49589672
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48079073
92One carbon pool by folate_Homo sapiens_hsa006700.46376918
93Fatty acid degradation_Homo sapiens_hsa000710.46287596
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44954370
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42029520
96Arachidonic acid metabolism_Homo sapiens_hsa005900.41345190
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40430613
98Carbon metabolism_Homo sapiens_hsa012000.38817267
99Sphingolipid metabolism_Homo sapiens_hsa006000.36906274
100Vitamin B6 metabolism_Homo sapiens_hsa007500.36414559

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