GALR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.90826998
2Golgi transport vesicle coating (GO:0048200)9.90826998
3signal peptide processing (GO:0006465)7.45056442
4endocrine pancreas development (GO:0031018)7.26640078
5protein maturation by protein folding (GO:0022417)6.88463263
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.71224252
7ER overload response (GO:0006983)6.56101812
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.04878098
9peptide hormone processing (GO:0016486)5.98115824
10COPII vesicle coating (GO:0048208)5.87686312
11sequestering of metal ion (GO:0051238)5.68219280
12insulin secretion (GO:0030073)5.61752756
13protein retention in ER lumen (GO:0006621)5.52655395
14regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.27691975
15regulation of type B pancreatic cell apoptotic process (GO:2000674)5.25134893
16detection of calcium ion (GO:0005513)5.16164516
17glandular epithelial cell differentiation (GO:0002067)5.15780864
18positive regulation of insulin secretion (GO:0032024)4.77888436
19activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.71531691
20regulation of insulin secretion (GO:0050796)4.70464542
21behavioral response to nicotine (GO:0035095)4.66115257
22detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.65012191
23vesicle coating (GO:0006901)4.54602713
24positive regulation of nuclease activity (GO:0032075)4.46276576
25behavioral response to ethanol (GO:0048149)4.46105336
26regulation of peptide hormone secretion (GO:0090276)4.31641641
27response to pheromone (GO:0019236)4.28453277
28intra-Golgi vesicle-mediated transport (GO:0006891)4.27855775
29type B pancreatic cell development (GO:0003323)4.24941344
30indolalkylamine metabolic process (GO:0006586)4.24683827
31regulation of peptide secretion (GO:0002791)4.24607628
32indole-containing compound catabolic process (GO:0042436)4.21668453
33indolalkylamine catabolic process (GO:0046218)4.21668453
34tryptophan catabolic process (GO:0006569)4.21668453
35exocrine pancreas development (GO:0031017)4.11984490
36GDP-mannose metabolic process (GO:0019673)4.11755793
37glandular epithelial cell development (GO:0002068)4.11378832
38protein localization to Golgi apparatus (GO:0034067)4.05010227
39cellular response to unfolded protein (GO:0034620)4.03187249
40regulation of nuclease activity (GO:0032069)4.02823398
41ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.99195695
42negative regulation of cytosolic calcium ion concentration (GO:0051481)3.98988992
43endoplasmic reticulum unfolded protein response (GO:0030968)3.96394275
44cellular response to topologically incorrect protein (GO:0035967)3.92429404
45positive regulation of peptide hormone secretion (GO:0090277)3.91844575
46peptide hormone secretion (GO:0030072)3.91133038
47negative regulation of bone resorption (GO:0045779)3.82815038
48positive regulation of peptide secretion (GO:0002793)3.81374327
49peptide secretion (GO:0002790)3.79869412
50ER-nucleus signaling pathway (GO:0006984)3.79273211
51kynurenine metabolic process (GO:0070189)3.74995820
52L-fucose catabolic process (GO:0042355)3.74020487
53fucose catabolic process (GO:0019317)3.74020487
54L-fucose metabolic process (GO:0042354)3.74020487
55regulation of hexokinase activity (GO:1903299)3.72860506
56regulation of glucokinase activity (GO:0033131)3.72860506
57negative regulation of insulin secretion (GO:0046676)3.71944875
58* regulation of hormone secretion (GO:0046883)3.70554558
59protein N-linked glycosylation via asparagine (GO:0018279)3.68252076
60regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.66794591
61nitric oxide mediated signal transduction (GO:0007263)3.66301051
62peptidyl-asparagine modification (GO:0018196)3.65367059
63toxin metabolic process (GO:0009404)3.62085864
64detection of light stimulus involved in sensory perception (GO:0050962)3.59099588
65detection of light stimulus involved in visual perception (GO:0050908)3.59099588
66tryptophan metabolic process (GO:0006568)3.59071606
67ER to Golgi vesicle-mediated transport (GO:0006888)3.55331806
68cellular zinc ion homeostasis (GO:0006882)3.53335014
69cellular response to vitamin D (GO:0071305)3.49121288
70regulation of Golgi to plasma membrane protein transport (GO:0042996)3.47226964
71regulation of peptide transport (GO:0090087)3.43322607
72lactate metabolic process (GO:0006089)3.41314684
73columnar/cuboidal epithelial cell development (GO:0002066)3.41278491
74cilium or flagellum-dependent cell motility (GO:0001539)3.41103818
75interleukin-1-mediated signaling pathway (GO:0070498)3.39831670
76protein N-linked glycosylation (GO:0006487)3.37079995
77purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.35072928
783-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.35072928
79negative regulation of peptide hormone secretion (GO:0090278)3.33863451
80inner ear receptor cell development (GO:0060119)3.32875297
81regulation of neurotransmitter uptake (GO:0051580)3.30018340
82regulation of oxidative phosphorylation (GO:0002082)3.29462918
83response to endoplasmic reticulum stress (GO:0034976)3.29289460
84neural tube formation (GO:0001841)3.29185834
85platelet dense granule organization (GO:0060155)3.28555255
86negative regulation of glycoprotein biosynthetic process (GO:0010561)3.25599529
87Golgi organization (GO:0007030)3.25327343
88reflex (GO:0060004)3.24359612
89protein K11-linked deubiquitination (GO:0035871)3.22092357
90axoneme assembly (GO:0035082)3.21889776
91negative regulation of peptide secretion (GO:0002792)3.20995222
92neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.17891167
93phasic smooth muscle contraction (GO:0014821)3.17469057
94indole-containing compound metabolic process (GO:0042430)3.15804203
95response to unfolded protein (GO:0006986)3.13676573
96cellular ketone body metabolic process (GO:0046950)3.13472940
97hormone secretion (GO:0046879)3.11042606
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.08208751
99peristalsis (GO:0030432)3.07560190
100negative regulation of bone remodeling (GO:0046851)3.06754588
101peptide transport (GO:0015833)3.06531584
102photoreceptor cell maintenance (GO:0045494)3.06496347
103response to topologically incorrect protein (GO:0035966)3.05280198
104negative regulation of catecholamine secretion (GO:0033604)3.05155331
105DNA deamination (GO:0045006)3.04063876
106response to hexose (GO:0009746)2.99817781
107* positive regulation of hormone secretion (GO:0046887)2.99122999
108zinc ion homeostasis (GO:0055069)2.98545709
109auditory receptor cell stereocilium organization (GO:0060088)2.97744441
110negative regulation of norepinephrine secretion (GO:0010700)2.97092660
111astrocyte differentiation (GO:0048708)2.97052162
112response to glucose (GO:0009749)2.96995688
113amine catabolic process (GO:0009310)2.96402301
114cellular biogenic amine catabolic process (GO:0042402)2.96402301
115negative regulation of mast cell activation (GO:0033004)2.96220036
116ketone body metabolic process (GO:1902224)2.96204315
117auditory behavior (GO:0031223)2.95702885
118regulation of autophagic vacuole assembly (GO:2000785)2.94761939
119hormone transport (GO:0009914)2.94060856
120induction of positive chemotaxis (GO:0050930)2.93486287
121regulation of hippo signaling (GO:0035330)2.92951905
122epithelial cilium movement (GO:0003351)2.92645505
123piRNA metabolic process (GO:0034587)2.92297357
124nucleoside diphosphate catabolic process (GO:0009134)2.91003048
125neuronal action potential (GO:0019228)2.90001958
126retinal cone cell development (GO:0046549)2.89255568
127epithelial cell fate commitment (GO:0072148)2.89029349
128detection of mechanical stimulus involved in sensory perception (GO:0050974)2.88535587
129cellular response to glucagon stimulus (GO:0071377)2.88016103
130cerebellar Purkinje cell layer development (GO:0021680)2.87728408
131sulfation (GO:0051923)2.87281187
132tachykinin receptor signaling pathway (GO:0007217)2.87110702
133inner ear receptor stereocilium organization (GO:0060122)2.86751630
134response to monosaccharide (GO:0034284)2.83850029
135water-soluble vitamin biosynthetic process (GO:0042364)2.83727851
136negative regulation of calcium ion transport into cytosol (GO:0010523)2.82232218
137Golgi vesicle transport (GO:0048193)2.81584513
138intestinal epithelial cell development (GO:0060576)2.80861639
139cilium organization (GO:0044782)2.79831865
140regulation of synaptic vesicle exocytosis (GO:2000300)2.79429065
141intraciliary transport (GO:0042073)2.78487377
142carbohydrate homeostasis (GO:0033500)2.78356330
143glucose homeostasis (GO:0042593)2.78356330
144L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.76926626
145dopamine transport (GO:0015872)2.75986759
146magnesium ion transport (GO:0015693)2.75837388
147cilium assembly (GO:0042384)2.74217466
148protein targeting to Golgi (GO:0000042)2.73213270
149fat-soluble vitamin biosynthetic process (GO:0042362)2.72907684
150response to hepatocyte growth factor (GO:0035728)2.71727582
151proline transport (GO:0015824)2.71367394
152G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.70797638
153cilium movement (GO:0003341)2.70143831
154cilium morphogenesis (GO:0060271)2.70117146
155thyroid hormone metabolic process (GO:0042403)2.69192719
156gamma-aminobutyric acid transport (GO:0015812)2.68209032
157mechanosensory behavior (GO:0007638)2.67617162
158regulation of action potential (GO:0098900)2.64811843
159regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.63341635
160regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.63341635
161nephron tubule morphogenesis (GO:0072078)2.62785134
162nephron epithelium morphogenesis (GO:0072088)2.62785134
163regulation of translation, ncRNA-mediated (GO:0045974)2.62473293
164negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.62473293
165negative regulation of translation, ncRNA-mediated (GO:0040033)2.62473293
166presynaptic membrane assembly (GO:0097105)2.62251214
167recombinational repair (GO:0000725)2.61444131
168DNA double-strand break processing (GO:0000729)2.61325832
169replication fork processing (GO:0031297)2.60918469
170protein localization to cilium (GO:0061512)2.60633665
171benzene-containing compound metabolic process (GO:0042537)2.60559881
172transmission of nerve impulse (GO:0019226)2.60326881
173double-strand break repair via homologous recombination (GO:0000724)2.60145481
174axon ensheathment in central nervous system (GO:0032291)2.57593997
175central nervous system myelination (GO:0022010)2.57593997
176cornea development in camera-type eye (GO:0061303)2.56267954
177multicellular organism reproduction (GO:0032504)2.56083427
178respiratory chain complex IV assembly (GO:0008535)2.55734292
179rhodopsin mediated signaling pathway (GO:0016056)2.55593533
180photoreceptor cell development (GO:0042461)2.55419212
181prenylation (GO:0097354)2.53568828
182protein prenylation (GO:0018342)2.53568828
183serotonin metabolic process (GO:0042428)2.52885986
184regulation of collateral sprouting (GO:0048670)2.52695897
185negative regulation of astrocyte differentiation (GO:0048712)2.52136426
186amino acid salvage (GO:0043102)2.51730492
187L-methionine salvage (GO:0071267)2.51730492
188L-methionine biosynthetic process (GO:0071265)2.51730492
189primary amino compound metabolic process (GO:1901160)2.51595701
190cellular response to sterol (GO:0036315)2.51484350
191startle response (GO:0001964)2.51362673
192reciprocal meiotic recombination (GO:0007131)2.51025201
193reciprocal DNA recombination (GO:0035825)2.51025201
194DNA methylation involved in gamete generation (GO:0043046)2.50668131
195regulation of rhodopsin mediated signaling pathway (GO:0022400)2.50632366
196establishment of protein localization to Golgi (GO:0072600)2.50509756
197aromatic amino acid family catabolic process (GO:0009074)2.49284324
198regulation of cilium movement (GO:0003352)2.47828913
199nonmotile primary cilium assembly (GO:0035058)2.47552178

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.05889794
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.31733007
3GATA1_22025678_ChIP-Seq_K562_Human4.16044986
4* PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.76713755
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88002710
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.79036076
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.68621286
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.55523653
9EZH2_22144423_ChIP-Seq_EOC_Human2.48635771
10GBX2_23144817_ChIP-Seq_PC3_Human2.32931906
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.21242284
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.17841367
13FUS_26573619_Chip-Seq_HEK293_Human2.17518471
14* REST_21632747_ChIP-Seq_MESCs_Mouse2.16929568
15EWS_26573619_Chip-Seq_HEK293_Human2.13288920
16TAF15_26573619_Chip-Seq_HEK293_Human2.08939591
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.05031451
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03035129
19ER_23166858_ChIP-Seq_MCF-7_Human1.89875693
20NR3C1_23031785_ChIP-Seq_PC12_Mouse1.83011001
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82200969
22* REST_18959480_ChIP-ChIP_MESCs_Mouse1.73790195
23MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.73649094
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.71335278
25REST_19997604_ChIP-ChIP_NEURONS_Mouse1.68693986
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68200306
27PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.67201713
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63938346
29IGF1R_20145208_ChIP-Seq_DFB_Human1.63771786
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60915843
31* CBP_20019798_ChIP-Seq_JUKART_Human1.59829840
32* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59829840
33AR_25329375_ChIP-Seq_VCAP_Human1.58062217
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55109290
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54028765
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54028765
37* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53841888
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.49963914
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49711176
40* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47597404
41STAT3_23295773_ChIP-Seq_U87_Human1.47342103
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46655476
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45336730
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44392250
45* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44308627
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.44135925
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.44004359
48SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.42854934
49* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.42314901
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.41950891
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41250996
52NANOG_19829295_ChIP-Seq_ESCs_Human1.40855200
53SOX2_19829295_ChIP-Seq_ESCs_Human1.40855200
54* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38864169
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38801535
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38025207
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37028155
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.36749417
59ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35830205
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.35461612
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32884363
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32843821
63AR_21572438_ChIP-Seq_LNCaP_Human1.32184248
64SMAD4_21799915_ChIP-Seq_A2780_Human1.29503636
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.26047403
66SMAD4_21741376_ChIP-Seq_EPCs_Human1.25736101
67* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25584391
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25027537
69IRF1_19129219_ChIP-ChIP_H3396_Human1.24119989
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23972443
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.21922280
72* PRDM14_20953172_ChIP-Seq_ESCs_Human1.21278340
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20330259
74* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.19583267
75TP53_22573176_ChIP-Seq_HFKS_Human1.19210396
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19177903
77SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18330186
78* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17103303
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.16489163
80CDX2_22108803_ChIP-Seq_LS180_Human1.16282275
81* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16185219
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.15573065
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.15120668
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15120668
85RNF2_27304074_Chip-Seq_NSC_Mouse1.14407430
86* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12362540
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12250196
88* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12130380
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10611275
90DROSHA_22980978_ChIP-Seq_HELA_Human1.10574816
91FOXA1_25552417_ChIP-Seq_VCAP_Human1.10422634
92* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08743681
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08629657
94PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08476581
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07476426
96CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07068017
97TCF4_23295773_ChIP-Seq_U87_Human1.06692740
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.06505469
99* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06296687
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05449731
101YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05429304
102OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05017181
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04057591
104* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03995366
105TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03501524
106* AR_20517297_ChIP-Seq_VCAP_Human1.03464111
107STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03116729
108* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03052089
109NCOR_22424771_ChIP-Seq_293T_Human1.02850407
110FLI1_21867929_ChIP-Seq_TH2_Mouse1.02398063
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01948905
112KDM2B_26808549_Chip-Seq_REH_Human1.01480830
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.01431769
114NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00760642
115EZH2_27294783_Chip-Seq_ESCs_Mouse1.00600748
116TP53_16413492_ChIP-PET_HCT116_Human1.00243117
117FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99061025
118SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98298957
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97917283
120BCAT_22108803_ChIP-Seq_LS180_Human0.97782141
121* SMAD3_21741376_ChIP-Seq_ESCs_Human0.97752907
122* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97665305
123SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97283488
124CMYC_18555785_Chip-Seq_ESCs_Mouse0.96559662
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96189396
126KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.95913178
127P300_19829295_ChIP-Seq_ESCs_Human0.95505941
128PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95354266
129FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95299756
130STAT3_18555785_Chip-Seq_ESCs_Mouse0.95097241
131CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94831910
132VDR_22108803_ChIP-Seq_LS180_Human0.93183262
133* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91490041
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91079225
135TFEB_21752829_ChIP-Seq_HELA_Human0.87931023
136TCF4_22108803_ChIP-Seq_LS180_Human0.86701189
137* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.86327217
138SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86276189
139BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84782010
140ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84065476
141CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83991537
142NMYC_18555785_Chip-Seq_ESCs_Mouse0.83959448
143TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83883176
144ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83529729
145* GF1B_26923725_Chip-Seq_HPCs_Mouse0.82919322
146* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82530632
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82513207
148* RUNX2_22187159_ChIP-Seq_PCA_Human0.82226512
149ERG_20517297_ChIP-Seq_VCAP_Human0.81708178
150ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81654747
151EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81375680
152LXR_22158963_ChIP-Seq_LIVER_Mouse0.81229789
153* ZNF274_21170338_ChIP-Seq_K562_Hela0.80293683
154* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.80276861
155* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.78894569
156GATA1_19941826_ChIP-Seq_K562_Human0.78057132
157* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77902358
158SOX2_20726797_ChIP-Seq_SW620_Human0.77172537
159ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76427991
160P53_22387025_ChIP-Seq_ESCs_Mouse0.76345001

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog5.34276313
2MP0004043_abnormal_pH_regulation4.83570847
3MP0010386_abnormal_urinary_bladder4.56165904
4MP0003283_abnormal_digestive_organ4.20598155
5MP0002693_abnormal_pancreas_physiology4.17622621
6MP0009780_abnormal_chondrocyte_physiolo4.12752871
7MP0003195_calcinosis3.71792158
8MP0001944_abnormal_pancreas_morphology3.69742707
9MP0000678_abnormal_parathyroid_gland3.68161082
10MP0000013_abnormal_adipose_tissue3.68151222
11MP0002909_abnormal_adrenal_gland3.35618420
12MP0005379_endocrine/exocrine_gland_phen3.23940183
13MP0003136_yellow_coat_color3.15252724
14MP0000569_abnormal_digit_pigmentation2.90374601
15MP0002837_dystrophic_cardiac_calcinosis2.70970702
16MP0005551_abnormal_eye_electrophysiolog2.56320589
17MP0008877_abnormal_DNA_methylation2.54707929
18MP0001986_abnormal_taste_sensitivity2.53866577
19MP0006072_abnormal_retinal_apoptosis2.46756475
20MP0005220_abnormal_exocrine_pancreas2.46159556
21MP0002078_abnormal_glucose_homeostasis2.34689094
22MP0005646_abnormal_pituitary_gland2.31919008
23MP0001968_abnormal_touch/_nociception2.25634030
24MP0003183_abnormal_peptide_metabolism2.25279047
25MP0002102_abnormal_ear_morphology2.21779317
26MP0009046_muscle_twitch2.21226928
27MP0000372_irregular_coat_pigmentation2.15140789
28MP0002822_catalepsy2.13619120
29MP0004270_analgesia2.09829924
30MP0002736_abnormal_nociception_after2.04782651
31MP0005645_abnormal_hypothalamus_physiol2.03920016
32MP0003122_maternal_imprinting1.98427060
33MP0002638_abnormal_pupillary_reflex1.98272396
34MP0003646_muscle_fatigue1.95570137
35MP0009745_abnormal_behavioral_response1.91153610
36MP0001485_abnormal_pinna_reflex1.78225006
37MP0001529_abnormal_vocalization1.78090858
38MP0000427_abnormal_hair_cycle1.76815929
39MP0001486_abnormal_startle_reflex1.75053486
40MP0002876_abnormal_thyroid_physiology1.74695689
41MP0008872_abnormal_physiological_respon1.69974119
42MP0000003_abnormal_adipose_tissue1.62845424
43MP0002928_abnormal_bile_duct1.60377962
44MP0004885_abnormal_endolymph1.58688848
45MP0002938_white_spotting1.57298399
46MP0001765_abnormal_ion_homeostasis1.55653321
47MP0005174_abnormal_tail_pigmentation1.55103062
48MP0004142_abnormal_muscle_tone1.54942922
49MP0002896_abnormal_bone_mineralization1.54201390
50MP0002139_abnormal_hepatobiliary_system1.53062585
51MP0003953_abnormal_hormone_level1.52649574
52MP0003868_abnormal_feces_composition1.52191384
53MP0005084_abnormal_gallbladder_morpholo1.45498098
54MP0006276_abnormal_autonomic_nervous1.42847608
55MP0003880_abnormal_central_pattern1.42646920
56MP0002163_abnormal_gland_morphology1.40478947
57MP0004147_increased_porphyrin_level1.37883691
58MP0001984_abnormal_olfaction1.35758967
59MP0004133_heterotaxia1.34951579
60MP0005535_abnormal_body_temperature1.34735775
61MP0000613_abnormal_salivary_gland1.31288774
62MP0003172_abnormal_lysosome_physiology1.30826318
63MP0005310_abnormal_salivary_gland1.30178353
64MP0005386_behavior/neurological_phenoty1.29716985
65MP0004924_abnormal_behavior1.29716985
66MP0002064_seizures1.29147744
67MP0008875_abnormal_xenobiotic_pharmacok1.27762914
68MP0005365_abnormal_bile_salt1.27498181
69MP0002138_abnormal_hepatobiliary_system1.26782238
70MP0005171_absent_coat_pigmentation1.22585016
71MP0000462_abnormal_digestive_system1.22435315
72MP0002733_abnormal_thermal_nociception1.21299830
73MP0009643_abnormal_urine_homeostasis1.17929663
74MP0005257_abnormal_intraocular_pressure1.15158609
75MP0008057_abnormal_DNA_replication1.15085993
76MP0002234_abnormal_pharynx_morphology1.14989072
77MP0000383_abnormal_hair_follicle1.14864645
78MP0005058_abnormal_lysosome_morphology1.12312620
79MP0002095_abnormal_skin_pigmentation1.11928660
80MP0000538_abnormal_urinary_bladder1.09503062
81MP0005636_abnormal_mineral_homeostasis1.09290982
82MP0002734_abnormal_mechanical_nocicepti1.09243229
83MP0000631_abnormal_neuroendocrine_gland1.08213365
84MP0002067_abnormal_sensory_capabilities1.08124342
85MP0004264_abnormal_extraembryonic_tissu1.07917665
86MP0005410_abnormal_fertilization1.07693188
87MP0005377_hearing/vestibular/ear_phenot1.06349452
88MP0003878_abnormal_ear_physiology1.06349452
89MP0005075_abnormal_melanosome_morpholog1.05703221
90MP0003252_abnormal_bile_duct1.05321335
91MP0003300_gastrointestinal_ulcer1.05125285
92MP0004742_abnormal_vestibular_system0.99998808
93MP0005167_abnormal_blood-brain_barrier0.99895769
94MP0005389_reproductive_system_phenotype0.98408509
95MP0001970_abnormal_pain_threshold0.96256583
96MP0005195_abnormal_posterior_eye0.96143217
97MP0003718_maternal_effect0.95828995
98MP0008995_early_reproductive_senescence0.95730046
99MP0003011_delayed_dark_adaptation0.94933483
100MP0002063_abnormal_learning/memory/cond0.92687726
101MP0004215_abnormal_myocardial_fiber0.91058769
102MP0002160_abnormal_reproductive_system0.90544482
103MP0000647_abnormal_sebaceous_gland0.90393052
104MP0001502_abnormal_circadian_rhythm0.90189469
105MP0001270_distended_abdomen0.89604412
106MP0003698_abnormal_male_reproductive0.88718095
107MP0003879_abnormal_hair_cell0.88001003
108MP0001756_abnormal_urination0.87541379
109MP0000026_abnormal_inner_ear0.86692624
110MP0005448_abnormal_energy_balance0.86445266
111MP0005187_abnormal_penis_morphology0.85758895
112MP0001324_abnormal_eye_pigmentation0.85753388
113MP0001501_abnormal_sleep_pattern0.84652893
114MP0001963_abnormal_hearing_physiology0.82883733
115MP0002752_abnormal_somatic_nervous0.82804995
116MP0001929_abnormal_gametogenesis0.82453147
117MP0001919_abnormal_reproductive_system0.82442873
118MP0005253_abnormal_eye_physiology0.82219592
119MP0002735_abnormal_chemical_nociception0.81628614
120MP0001666_abnormal_nutrient_absorption0.81421109
121MP0004145_abnormal_muscle_electrophysio0.81394854
122MP0001764_abnormal_homeostasis0.81066544
123MP0008961_abnormal_basal_metabolism0.80979826
124MP0003959_abnormal_lean_body0.80817265
125MP0001905_abnormal_dopamine_level0.79522419
126MP0003890_abnormal_embryonic-extraembry0.78961146
127MP0000230_abnormal_systemic_arterial0.78817397
128MP0005367_renal/urinary_system_phenotyp0.78308833
129MP0000516_abnormal_urinary_system0.78308833
130MP0008775_abnormal_heart_ventricle0.77521389
131MP0000681_abnormal_thyroid_gland0.77262443
132MP0002277_abnormal_respiratory_mucosa0.74868087
133MP0003635_abnormal_synaptic_transmissio0.71973832
134MP0009672_abnormal_birth_weight0.71857351
135MP0002272_abnormal_nervous_system0.68995641
136MP0002653_abnormal_ependyma_morphology0.68761848
137MP0000639_abnormal_adrenal_gland0.68148642
138MP0002069_abnormal_eating/drinking_beha0.68109286
139MP0002751_abnormal_autonomic_nervous0.67591289
140MP0003866_abnormal_defecation0.67340782
141MP0001664_abnormal_digestion0.67241280
142MP0005408_hypopigmentation0.65194989
143MP0003119_abnormal_digestive_system0.64883152
144MP0000955_abnormal_spinal_cord0.64805814
145MP0002557_abnormal_social/conspecific_i0.63686279
146MP0002118_abnormal_lipid_homeostasis0.63666513
147MP0003787_abnormal_imprinting0.61096793
148MP0004782_abnormal_surfactant_physiolog0.60179521
149MP0004085_abnormal_heartbeat0.58518115
150MP0003633_abnormal_nervous_system0.58517349
151MP0002572_abnormal_emotion/affect_behav0.58009862
152MP0005375_adipose_tissue_phenotype0.57312229
153MP0006292_abnormal_olfactory_placode0.55528860
154MP0005334_abnormal_fat_pad0.54251818
155MP0002009_preneoplasia0.54224887
156MP0002229_neurodegeneration0.54059947
157MP0001186_pigmentation_phenotype0.52474138
158MP0009642_abnormal_blood_homeostasis0.52134758
159MP0001188_hyperpigmentation0.52120306
160MP0003634_abnormal_glial_cell0.51638788
161MP0002177_abnormal_outer_ear0.51104693
162MP0003795_abnormal_bone_structure0.50735607
163MP0005085_abnormal_gallbladder_physiolo0.50403636
164MP0003045_fibrosis0.50306424

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.97455542
2Symptomatic seizures (HP:0011145)7.77629769
3Hyperinsulinemic hypoglycemia (HP:0000825)7.50270710
4Hypoglycemic seizures (HP:0002173)7.06966839
5Hypoglycemic coma (HP:0001325)5.82703913
6Generalized aminoaciduria (HP:0002909)5.59527496
7Abnormality of calcium-phosphate metabolism (HP:0100530)4.81666446
8Hyperglycemia (HP:0003074)4.68477762
9Pancreatic cysts (HP:0001737)4.66085484
10Insulin-resistant diabetes mellitus (HP:0000831)4.57371593
11True hermaphroditism (HP:0010459)4.45909319
12Abnormality of endocrine pancreas physiology (HP:0012093)4.40376505
13Abnormality of the pancreatic islet cells (HP:0006476)4.40376505
14Pancreatic fibrosis (HP:0100732)4.39911874
15Pancreatic islet-cell hyperplasia (HP:0004510)4.02497272
16Abnormal pancreas size (HP:0012094)3.97261344
17Abnormality of midbrain morphology (HP:0002418)3.84443576
18Molar tooth sign on MRI (HP:0002419)3.84443576
19Congenital stationary night blindness (HP:0007642)3.82164059
20Abnormality of the intrinsic pathway (HP:0010989)3.71644991
21Decreased circulating renin level (HP:0003351)3.71534717
22Late onset (HP:0003584)3.68331506
23Ketoacidosis (HP:0001993)3.67685854
24Large for gestational age (HP:0001520)3.57063481
25Chronic hepatic failure (HP:0100626)3.48276313
26Hyperventilation (HP:0002883)3.47008607
27Nephronophthisis (HP:0000090)3.44100519
28Abnormality of aromatic amino acid family metabolism (HP:0004338)3.43295486
29Attenuation of retinal blood vessels (HP:0007843)3.39594126
30Osteomalacia (HP:0002749)3.37683205
31Conjugated hyperbilirubinemia (HP:0002908)3.33800196
32Hypothermia (HP:0002045)3.28881893
33Abnormality of the renal cortex (HP:0011035)3.28542684
34Hypokalemia (HP:0002900)3.27822760
35Gaze-evoked nystagmus (HP:0000640)3.26512998
36Abnormality of the renal medulla (HP:0100957)3.15990241
37Hyperparathyroidism (HP:0000843)3.09905583
38Medial flaring of the eyebrow (HP:0010747)3.03813175
39Abolished electroretinogram (ERG) (HP:0000550)3.01933083
40Cystic liver disease (HP:0006706)2.96686604
41Type II lissencephaly (HP:0007260)2.95794191
42Mucopolysacchariduria (HP:0008155)2.86822149
43Urinary glycosaminoglycan excretion (HP:0003541)2.86822149
44Dysostosis multiplex (HP:0000943)2.85309612
45Dysautonomia (HP:0002459)2.73687110
46Agitation (HP:0000713)2.65359137
47Decreased central vision (HP:0007663)2.61908364
48Thin bony cortex (HP:0002753)2.61901584
49Abnormality of potassium homeostasis (HP:0011042)2.61359759
50Insulin resistance (HP:0000855)2.61022713
51Progressive cerebellar ataxia (HP:0002073)2.59791621
52Abnormal rod and cone electroretinograms (HP:0008323)2.59321135
53Abnormality of renin-angiotensin system (HP:0000847)2.59095053
54Abnormality of polysaccharide metabolism (HP:0011012)2.58735166
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.58735166
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.58735166
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.57914148
58Keratoconus (HP:0000563)2.54913542
59Increased corneal curvature (HP:0100692)2.54913542
60Aplasia/Hypoplasia of the tibia (HP:0005772)2.53027550
61Sclerocornea (HP:0000647)2.52306833
62EEG with generalized epileptiform discharges (HP:0011198)2.51639808
63Febrile seizures (HP:0002373)2.51065123
64Hypophosphatemia (HP:0002148)2.50721078
65Polydipsia (HP:0001959)2.50335074
66Abnormal drinking behavior (HP:0030082)2.50335074
67Hypoplasia of the fovea (HP:0007750)2.49128362
68Aplasia/Hypoplasia of the fovea (HP:0008060)2.49128362
69Protuberant abdomen (HP:0001538)2.48242686
70Pendular nystagmus (HP:0012043)2.48236787
71Abnormality of alanine metabolism (HP:0010916)2.47824209
72Hyperalaninemia (HP:0003348)2.47824209
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47824209
74Pheochromocytoma (HP:0002666)2.47070662
75Bony spicule pigmentary retinopathy (HP:0007737)2.46990023
76Hypsarrhythmia (HP:0002521)2.43635128
77Widely patent fontanelles and sutures (HP:0004492)2.42575000
78Cerebellar dysplasia (HP:0007033)2.42509931
79Prominent metopic ridge (HP:0005487)2.42412629
80Gait imbalance (HP:0002141)2.42293938
81Epileptiform EEG discharges (HP:0011182)2.40835824
82Inability to walk (HP:0002540)2.39627620
83Tubular atrophy (HP:0000092)2.39537753
84Congenital sensorineural hearing impairment (HP:0008527)2.38269925
85Congenital primary aphakia (HP:0007707)2.38092342
86Anencephaly (HP:0002323)2.36455071
87Renal cortical cysts (HP:0000803)2.35895874
88Focal motor seizures (HP:0011153)2.34985619
89Enlarged epiphyses (HP:0010580)2.33190226
90Congenital hepatic fibrosis (HP:0002612)2.32187248
91Genetic anticipation (HP:0003743)2.31840634
92Dynein arm defect of respiratory motile cilia (HP:0012255)2.30876718
93Absent/shortened dynein arms (HP:0200106)2.30876718
94Abnormality of macular pigmentation (HP:0008002)2.30103375
95Exocrine pancreatic insufficiency (HP:0001738)2.29868992
96Limb hypertonia (HP:0002509)2.28532037
97Visual hallucinations (HP:0002367)2.25775616
98Abdominal distention (HP:0003270)2.23423551
99Male pseudohermaphroditism (HP:0000037)2.23140916
100Hyperkalemia (HP:0002153)2.22910186
101Abnormal protein glycosylation (HP:0012346)2.22784734
102Abnormal glycosylation (HP:0012345)2.22784734
103Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.22784734
104Abnormal protein N-linked glycosylation (HP:0012347)2.22784734
105Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22504341
106Postaxial foot polydactyly (HP:0001830)2.22082878
107Hemiparesis (HP:0001269)2.21746652
108Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21600101
109Clumsiness (HP:0002312)2.21517892
110Protruding tongue (HP:0010808)2.20468301
111Furrowed tongue (HP:0000221)2.20210093
112Irregular vertebral endplates (HP:0003301)2.19488414
113Fair hair (HP:0002286)2.19445532
114Intestinal atresia (HP:0011100)2.19348081
115Absent speech (HP:0001344)2.18595650
116Metaphyseal irregularity (HP:0003025)2.17254816
117Nephrogenic diabetes insipidus (HP:0009806)2.17008543
118Abnormality of the fovea (HP:0000493)2.16226730
119Progressive inability to walk (HP:0002505)2.13348290
120Optic nerve hypoplasia (HP:0000609)2.12533186
121Ketosis (HP:0001946)2.10086781
122Aplasia/Hypoplasia of the uvula (HP:0010293)2.09984427
123Genital tract atresia (HP:0001827)2.09976278
124Delayed epiphyseal ossification (HP:0002663)2.09688239
125Bifid tongue (HP:0010297)2.09532653
126Neuroendocrine neoplasm (HP:0100634)2.08813008
127Constricted visual fields (HP:0001133)2.08705904
128Dialeptic seizures (HP:0011146)2.08452289
129Chorioretinal atrophy (HP:0000533)2.08265002
130Hyperphosphaturia (HP:0003109)2.08054888
131Type I transferrin isoform profile (HP:0003642)2.07649848
132Abnormality of the metopic suture (HP:0005556)2.06991298
133Focal seizures (HP:0007359)2.06939379
134Broad-based gait (HP:0002136)2.05035776
135Abnormal ciliary motility (HP:0012262)2.04974685
136Congenital, generalized hypertrichosis (HP:0004540)2.03631885
137Stomach cancer (HP:0012126)2.01304011
138Elevated alkaline phosphatase (HP:0003155)2.00194834
139Increased circulating renin level (HP:0000848)1.99484088
140Retinal atrophy (HP:0001105)1.99026397
141Hyperactive renin-angiotensin system (HP:0000841)1.98755947
142Progressive neurologic deterioration (HP:0002344)1.97500601
143Macroorchidism (HP:0000053)1.95994540
144Abnormality of the costochondral junction (HP:0000919)1.95715844
145Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94273351
146Cortical visual impairment (HP:0100704)1.93804208
147Abnormality of the pons (HP:0007361)1.93210499
148Vaginal atresia (HP:0000148)1.92504987
149Widely spaced teeth (HP:0000687)1.90762638
150Lissencephaly (HP:0001339)1.89833589
151Thoracolumbar scoliosis (HP:0002944)1.89417980
152Menstrual irregularities (HP:0000858)1.87814213
153Absent eyebrow (HP:0002223)1.86281386
154Abnormality of alkaline phosphatase activity (HP:0004379)1.85540313
155Papilledema (HP:0001085)1.85294355
156Preaxial hand polydactyly (HP:0001177)1.85111844
157Abnormal respiratory epithelium morphology (HP:0012253)1.83875985
158Abnormal respiratory motile cilium morphology (HP:0005938)1.83875985
159Hypotension (HP:0002615)1.83488184
160Postaxial hand polydactyly (HP:0001162)1.82603595
161Hypoplasia of the pons (HP:0012110)1.82592947
162Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82489561
163Acute hepatic failure (HP:0006554)1.81207150
164Hyperphosphatemia (HP:0002905)1.80591157
165Abnormal biliary tract physiology (HP:0012439)1.80106941
166Bile duct proliferation (HP:0001408)1.80106941
167Anteriorly placed anus (HP:0001545)1.79572281
168Abnormality of the labia minora (HP:0012880)1.78208341
169Retinal dysplasia (HP:0007973)1.77101318
170Poor coordination (HP:0002370)1.75841949
171Gout (HP:0001997)1.75543351
172Astigmatism (HP:0000483)1.74890028
173Glycosuria (HP:0003076)1.74651162
174Abnormality of urine glucose concentration (HP:0011016)1.74651162
175Irritability (HP:0000737)1.74543647
176Generalized hypopigmentation of hair (HP:0011358)1.74011307
177Abnormal enzyme/coenzyme activity (HP:0012379)1.73045567
178Polyuria (HP:0000103)1.72625144
179Abnormality of the common coagulation pathway (HP:0010990)1.72175760
180Occipital encephalocele (HP:0002085)1.71835494
181Glucose intolerance (HP:0000833)1.71815791
182Retinitis pigmentosa (HP:0000510)1.70476005
183Atonic seizures (HP:0010819)1.70085471
184Thyroid-stimulating hormone excess (HP:0002925)1.69323539
185Disproportionate short-trunk short stature (HP:0003521)1.67483334
186Unilateral renal agenesis (HP:0000122)1.67320524
187Prolonged partial thromboplastin time (HP:0003645)1.67192722
188Abnormality of purine metabolism (HP:0004352)1.66843566
189Papillary thyroid carcinoma (HP:0002895)1.66629717
190Short tibia (HP:0005736)1.66247148
191Central scotoma (HP:0000603)1.64877051

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR8.52648064
2PASK5.01044795
3PRKD33.68964949
4MAPK153.50994771
5MAP3K23.50348081
6HIPK22.97779804
7FRK2.78030959
8MAP4K22.62724695
9IRAK32.50828276
10NTRK12.49880998
11ACVR1B2.48584190
12NUAK12.39261903
13NTRK32.30733995
14GRK12.25287644
15TAOK32.17316371
16ZAK2.15365170
17EIF2AK32.07430897
18AKT32.02062723
19WNK41.92929896
20CASK1.90777194
21IRAK11.85676286
22CDC42BPA1.66425527
23TNIK1.61146589
24STK391.54753238
25OXSR11.51721792
26FLT31.48847672
27PNCK1.47328874
28MKNK21.45415130
29SCYL21.40970423
30STK38L1.36208922
31TRIM281.26786206
32TLK11.26010812
33EPHA31.24179291
34PRKCH1.22695013
35MUSK1.22276263
36UHMK11.20454716
37MAP3K41.20081006
38CAMKK21.11416424
39TXK1.08904028
40PLK21.07843099
41NME11.03579553
42WEE11.02101512
43DAPK21.02002806
44ERN11.01492615
45WNK31.01182880
46MAP3K10.99316759
47IRAK20.97829114
48MAP2K20.96037428
49PTK2B0.94350506
50LATS10.91900564
51PAK30.90897196
52FGFR20.90396500
53PRKCE0.90181159
54TGFBR10.89350768
55PTK20.88787266
56BCKDK0.88619932
57BRSK20.88118147
58PDGFRA0.85066184
59VRK10.84748210
60STK30.84734306
61MARK10.83014870
62BMPR20.82152981
63PTK60.80509860
64CSNK1G10.76493022
65STK160.76268112
66RPS6KA20.73489038
67SGK20.71892218
68BRAF0.70360299
69SGK4940.69617771
70SGK2230.69617771
71CSNK1G20.69557261
72MET0.69337918
73PRKD20.69202328
74MKNK10.69027966
75CAMK2D0.68705865
76MAPK130.66445910
77RET0.66403090
78BMPR1B0.64618857
79PLK40.63485666
80IRAK40.63064881
81MST40.62732197
82PRKG20.62077886
83DYRK20.61986474
84PLK30.61056068
85IKBKB0.60882517
86WNK10.59510113
87NTRK20.58321511
88CSNK1G30.58186166
89KSR20.57971653
90DYRK1B0.57732094
91ITK0.56499325
92KIT0.55410101
93BRD40.55044484
94FER0.55027464
95ERBB30.55012990
96TNK20.53867254
97TIE10.53845696
98EPHA40.51841100
99MAPKAPK30.49951658
100CAMK1G0.48401963
101PRKACG0.47476248
102CAMK10.47371260
103GSK3A0.46443350
104ADRBK20.45938240
105PIK3CG0.45673202
106MAPKAPK50.45567884
107CAMK1D0.45503147
108RPS6KB10.45394778
109PHKG20.45169405
110PHKG10.45169405
111PRKCG0.44543953
112MAP2K70.44510313
113PRKAA20.43780831
114MAP2K10.43632634
115PRKCQ0.43439350
116PIK3CA0.43356835
117PKN10.42717355
118CDK50.42312414
119CSNK1A10.41041901
120CDK30.40898571
121PINK10.40803840
122OBSCN0.40460171
123TESK10.40346732
124PRKAA10.39276026
125PRKACA0.39056922
126TEC0.38713128
127JAK20.38290970
128PRKG10.37383810
129TSSK60.36969774
130SGK30.36379526
131PRKD10.36060292
132CSNK1D0.35568707
133CHUK0.34643990
134PRKCI0.32443262
135ADRBK10.32270853
136CAMK2B0.32196666
137FGFR40.32043190
138PRKDC0.31223989
139SIK20.30215727
140MAP3K70.29477910
141CAMKK10.29348604
142NLK0.29082945
143DYRK1A0.26753370
144PRKCA0.26434125
145MAP3K30.26329739
146RPS6KA30.26135558
147CAMK2A0.25309572
148CSNK1A1L0.25141088
149BCR0.25130330
150PRKCB0.24951902
151SGK10.24798758
152IGF1R0.22787614
153SIK10.22316371
154GRK50.21896215
155AKT10.21416416
156CAMK2G0.20999712
157MAPK100.20983562
158MAPK30.19477602

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.59345450
2Protein export_Homo sapiens_hsa030606.37088100
3Insulin secretion_Homo sapiens_hsa049113.43575883
4Sulfur metabolism_Homo sapiens_hsa009203.31072789
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.09550348
6Phototransduction_Homo sapiens_hsa047442.98902903
7Nitrogen metabolism_Homo sapiens_hsa009102.54497594
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.53903004
9Nicotine addiction_Homo sapiens_hsa050332.30710615
10Vibrio cholerae infection_Homo sapiens_hsa051102.26126496
11Type II diabetes mellitus_Homo sapiens_hsa049302.20227420
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05757903
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02448975
14N-Glycan biosynthesis_Homo sapiens_hsa005101.91564510
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.89408894
16Homologous recombination_Homo sapiens_hsa034401.88605355
17Ether lipid metabolism_Homo sapiens_hsa005651.86006339
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.84432605
19Fanconi anemia pathway_Homo sapiens_hsa034601.67733015
20Type I diabetes mellitus_Homo sapiens_hsa049401.65978143
21Cocaine addiction_Homo sapiens_hsa050301.64811730
22Propanoate metabolism_Homo sapiens_hsa006401.57246025
23Caffeine metabolism_Homo sapiens_hsa002321.55838334
24Selenocompound metabolism_Homo sapiens_hsa004501.54891904
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.47073963
26RNA polymerase_Homo sapiens_hsa030201.43066589
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41897355
28Amphetamine addiction_Homo sapiens_hsa050311.40905280
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39791104
30Folate biosynthesis_Homo sapiens_hsa007901.36396594
31Basal transcription factors_Homo sapiens_hsa030221.36269455
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35919073
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31493432
34Chemical carcinogenesis_Homo sapiens_hsa052041.28713968
35Retinol metabolism_Homo sapiens_hsa008301.21261063
36One carbon pool by folate_Homo sapiens_hsa006701.20426469
37Synaptic vesicle cycle_Homo sapiens_hsa047211.20194489
38Peroxisome_Homo sapiens_hsa041461.19454144
39Collecting duct acid secretion_Homo sapiens_hsa049661.12210916
40Glycerolipid metabolism_Homo sapiens_hsa005611.12188316
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11411354
42Taste transduction_Homo sapiens_hsa047421.10981360
43beta-Alanine metabolism_Homo sapiens_hsa004101.10966832
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08797445
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05109081
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04545891
47Lysosome_Homo sapiens_hsa041421.04336763
48GABAergic synapse_Homo sapiens_hsa047271.03379173
49Dopaminergic synapse_Homo sapiens_hsa047281.02867962
50Circadian entrainment_Homo sapiens_hsa047131.01725887
51Circadian rhythm_Homo sapiens_hsa047101.00765659
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98573295
53Salivary secretion_Homo sapiens_hsa049700.97627084
54Glucagon signaling pathway_Homo sapiens_hsa049220.96943786
55Thyroid hormone synthesis_Homo sapiens_hsa049180.96779720
56Regulation of autophagy_Homo sapiens_hsa041400.96215208
57Arachidonic acid metabolism_Homo sapiens_hsa005900.96172353
58Long-term potentiation_Homo sapiens_hsa047200.95600968
59Serotonergic synapse_Homo sapiens_hsa047260.94386982
60Galactose metabolism_Homo sapiens_hsa000520.93140805
61Calcium signaling pathway_Homo sapiens_hsa040200.93070852
62Cholinergic synapse_Homo sapiens_hsa047250.91535965
63Pancreatic secretion_Homo sapiens_hsa049720.91246109
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88876251
65Tryptophan metabolism_Homo sapiens_hsa003800.88601814
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.88014837
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85939842
68Butanoate metabolism_Homo sapiens_hsa006500.85169211
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82413421
70RNA degradation_Homo sapiens_hsa030180.82315681
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81800448
72Parkinsons disease_Homo sapiens_hsa050120.81503509
73Other glycan degradation_Homo sapiens_hsa005110.81483062
74Non-homologous end-joining_Homo sapiens_hsa034500.80229127
75Morphine addiction_Homo sapiens_hsa050320.79427343
76ABC transporters_Homo sapiens_hsa020100.78006973
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77253995
78Insulin resistance_Homo sapiens_hsa049310.76808460
79Prolactin signaling pathway_Homo sapiens_hsa049170.76391217
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.75458841
81Phenylalanine metabolism_Homo sapiens_hsa003600.74184186
82Purine metabolism_Homo sapiens_hsa002300.72731709
83Sphingolipid metabolism_Homo sapiens_hsa006000.72582614
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70680552
85Estrogen signaling pathway_Homo sapiens_hsa049150.69990154
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69580037
87Steroid biosynthesis_Homo sapiens_hsa001000.68796401
88Prion diseases_Homo sapiens_hsa050200.67283639
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66728964
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66616981
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66242461
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65304553
93Starch and sucrose metabolism_Homo sapiens_hsa005000.62828954
94Histidine metabolism_Homo sapiens_hsa003400.62563645
95Huntingtons disease_Homo sapiens_hsa050160.61687887
96Fat digestion and absorption_Homo sapiens_hsa049750.58123639
97Fructose and mannose metabolism_Homo sapiens_hsa000510.57349803
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.57113321
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57108960
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56770773
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56129392
102Alcoholism_Homo sapiens_hsa050340.54981153
103Metabolic pathways_Homo sapiens_hsa011000.54339506
104Renin secretion_Homo sapiens_hsa049240.54237525
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52712769
106Dorso-ventral axis formation_Homo sapiens_hsa043200.51646707
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48329796
108Vitamin digestion and absorption_Homo sapiens_hsa049770.47673422
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.46768544
110Hedgehog signaling pathway_Homo sapiens_hsa043400.46213374
111Oxidative phosphorylation_Homo sapiens_hsa001900.45513684
112Glutamatergic synapse_Homo sapiens_hsa047240.42442586
113Fatty acid metabolism_Homo sapiens_hsa012120.42155206
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41997360
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41287763
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40400697
117Mineral absorption_Homo sapiens_hsa049780.39989420
118Alzheimers disease_Homo sapiens_hsa050100.39707022
119Insulin signaling pathway_Homo sapiens_hsa049100.38372427
120cAMP signaling pathway_Homo sapiens_hsa040240.35614086
121Phagosome_Homo sapiens_hsa041450.35419139
122Cardiac muscle contraction_Homo sapiens_hsa042600.34330019
123Tyrosine metabolism_Homo sapiens_hsa003500.34202579
124Linoleic acid metabolism_Homo sapiens_hsa005910.32979525
125Fatty acid biosynthesis_Homo sapiens_hsa000610.31862837
126Asthma_Homo sapiens_hsa053100.31455451
127Pyrimidine metabolism_Homo sapiens_hsa002400.31041250
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30446146
129Long-term depression_Homo sapiens_hsa047300.30236260
130Thyroid cancer_Homo sapiens_hsa052160.29941093
131Antigen processing and presentation_Homo sapiens_hsa046120.27713697
132AMPK signaling pathway_Homo sapiens_hsa041520.26595868
133Inositol phosphate metabolism_Homo sapiens_hsa005620.26591508
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26496026
135Fatty acid degradation_Homo sapiens_hsa000710.24523346
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23868684
137Gastric acid secretion_Homo sapiens_hsa049710.20526761
138Prostate cancer_Homo sapiens_hsa052150.20488809
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20316740
140Fatty acid elongation_Homo sapiens_hsa000620.19898951
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19380234
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18877914
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18064608
144* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16223194
145Lysine degradation_Homo sapiens_hsa003100.15374885
146Protein digestion and absorption_Homo sapiens_hsa049740.14413856
147Melanogenesis_Homo sapiens_hsa049160.14121586
148Ovarian steroidogenesis_Homo sapiens_hsa049130.13476306
149Olfactory transduction_Homo sapiens_hsa047400.12562073
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.12323054
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.11656908

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